Table Of Content

british journal of haematology Volume 126, 2004 Pages 1-896 Editors lan Hann Finbarr Cotter John Reilly Associate Editors R. Auer I]. A. G. Roberts H. E. Broxmeyer D. Rund M. Greaves N. Russell M. Y. Gordon S. L. Thein I. R. Peake L. Williamson M. J. Pippard Editorial Board I. R. Peake (Chairman) T. L. Holyoake T. Baglin M. Le Beau B. J. Bain D. Linch M. Barnett M. Makris J. Boultwood D. R. Miller C. Camaschella P. A. H. Moss R. Chopra A. Nurden C. J. Eaves D. Pamphilon C. Fegan G. H. Prentice A. Goodeve D. Provan A. R. Green D. Rees J. D. Griffin O. P. Smith H. Heslop M. Worwood Blackwell 9 Publishing 2004 British Journal of Haemotology Blackwell Publishing Ltd Published by Blackwell Publishing Ltd Editorial Offices Blackwell Publishing Ltd. 101 George Street, Edinburgh EH2 3ES, UK Blackwell Publishing Ltd. 9600 Garsington Road, Oxford OX4 2DQ, UK Blackwell Publishing Asia Pty. 550 Swanson Street, Carlton South, Victoria, VIC 3053, Australia, and GS Chiyoda Building, 5F, 3-11-14 lidabashi, Chiyoda-ku, Tokyo 102-0072, Japan Blackwell Publishing Europe Ltd. 10 rue Casimir Delavigne, F-75006, Paris, France Blackwell Verlag, Kurfiirstendamm 58, D-10707 Berlin, Germany Blackwell Publishing KK, GS Chiyoda Building, 3-11-14 lidabashi, Chiyoda-ku Tokyo 102-0072, Japan Blackwell Publishing Inc., Commerce Place, 350 Main Street, Malden, MA 02148-5018, USA Blackwell Munksgaard, 1, Rosenorns Alle, P.O. 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British Journal of Haemotology is covered by Adonis, ASCA, Chemical Abstracts, Currently Awareness in Biological Sciences, Current Clinical Cancer, Index Medicus, ISI/BIOMED and Science cittaottti on s ITena de > x ISSN0007-1048 Typeset by Scientific Publishing Services India and printed by the Alden Group, Oxford, UK british journal of haematology Volume 126, 2004 Pages 1-896 Issue 1, July-I 2004 images in Haematology Bone marrow architecture in acute myeloid/erythroid leukaemia S. M. McCloskey, M. F. McMullin, T. C. M. Morris and G. M. Markey Immune complications of B-cell chronic lymphatic leukaemia J. Travers, M. Leach and R. Jackson Review Leukaemia — a developmental perspective S. Izraeli Guideline Guidelines for the use of fresh-frozen plasma, cryoprecipitate and cryosupernatant British Committee for Standards in Haematology, Blood Transfusion Task Force, J. Duguid, D. F. O'Shaughnessy, C. Atterbury, P. Bolton Maggs, M. Murphy, D. Thomas, S. Yates and L. M. Williamson Haematological Malignancy Analysis of IgV, gene mutations in B cell chronic lymphocytic leukaemia according to antigen-driven selection identifies subgroups with different prognosis and usage of the canonical somatic hypermutation machinery M. Degan, R. Bomben, M. D. Bo, A. Zucchetto, P. Nanni, M. Rupolo, A. Steffan, V. Attadia, P. F. Ballerini, D. Damiani, C. Pucillo, G. Del Poeta, A. Colombatti and V. Gattei Most cases of primary salivary mucosa-associated lymphoid tissue lymphoma are associated either with Sjoegren syndrome or hepatitis C virus infection A. Ambrosetti, R. Zanotti, C. Pattaro, L. Lenzi, M. Chilosi, P. Caramaschi, L. Arcaini, F. Pasini, D. Biasi, E. Orlandi, M. D’Adda, M. Lucioni and G. Pizzolo Mutational analysis of the IxBx gene in activated B cell-like diffuse large B-cell lymphoma R. K. Thomas, C. Wickenhauser, S. Tawadros, V. Diehl, R. Kiippers, J. Wolf and R. Schmitz Characteristic expansion of CD45RA* CD27 CD28 CCR7 lymphocytes with stable natural killer (NK) receptor expression in NK- and T-cell type lymphoproliferative disease of granular lymphocytes T. Mitsui, I. Maekawa, A. Yamane, T. Ishikawa, H. Koiso, A. Yokohama, H. Handa, T. Matsushima, N. Tsukamoto, H. Murakami, Y. Nojima and M. Karasawa Clonal haemopoiesis may occur after conventional chemotherapy and is associated with accelerated telomere shortening and defects in the NQO1 pathway; possible mechanisms leading to an increased risk of t-AML/MDS L. Fern, M. Pallis, G. I. Carter, C. Seedhouse, N. Russell and J. Byrne "79 Correlation of TACC3, FGFR3, MMSET and p21 expression with the t(4;14)(p16.3;q32) in multiple myeloma J. P. Stewart, A. Thompson, M. Santra, B. Barlogie, T. R. J. Lappin and J. Shaughnessy Jr Short reports Blood dendritic cells in patients with acute lymphoblastic leukaemia N. Ben Mami, M. Mohty, H. Chambost, B. Gaugler and D. Olive Expression of FoxP3, a key molecule in CD4*°CD25"* regulatory T cells, in adult T-cell leukaemia/lymphoma cells K. Karube, K. Ohshima, T. Tsuchiya, T. Yamaguchi, R. Kawano, J. Suzumiya, 1. Utsunomiya, M. Harada and M. Kikuchi Platelets, Haemostasis and Thrombosis Haemostatic and inflammatory biomarkers in advanced chronic heart failure: role of oral anticoagulants and successful heart transplantation M. Cugno, D. Mari, P. L. Meroni, E. Gronda, F. Vicari, M. Frigerio, R. Coppola, B. Bottasso, M. O. Borghi and L. Gregorini Assessment of an immature platelet fraction (IPF) in peripheral thrombocytopenia C. Briggs, S. Kunka, D. Hart, S. Oguni and S. J. Machin Response to desmopressin of factors XI, X and V in patients with factor VIII deficiency and von Willebrand disease B. White, P. Lawler, A. Riddell, I. C. Nitu-Whalley, C. Hermans, C. A. Lee and S. A. Brown Two novel mutations in severe factor VII deficiency K. Gomez, M. A. Laffan, G. Kemball-Cook, J. Pasi, M. Layton, J. D. Singer, E. G. D. Tuddenham and J. H. McVey Haemopoiesis and Leucocytes A mouse model to study organ homing behaviour of haemopoietic progenitor cells reveals high selectivity but low efficiency of multipotent progenitors to home into haemopoietic organs R. Henschler, Z. Fehervizyova, R. Bistrian and E. Seifried Renin—angiotensin system expression in rat bone marrow haematopoietic and stromal cells W. B. Strawn, R. S. Richmond, E. A. Tallant, P. E. Gallagher and C. M. Ferrario Efficacy and safety of two different rG-CSF preparations in the treatment of patients with severe congenital neutropenia G. Carlsson, A. Ahlin, G. Dahlléf, G. Elinder, J.-I. Henter and J. Palmblad Red Cells and Iron Natural history of paroxysmal nocturnal haemoglobinuria using modern diagnostic assays V. M. Moyo, G. L. Mukhina, E. S. Garrett and R. A. Brodsky Transfusion Is fresh frozen plasma clinically effective? A systematic review of randomized controlled trials S. J. Stanworth, S. J. Brunskill, C. J. Hyde, D. B. L. McClelland and M. F. Murphy Improved extension of platelet storage in a polyolefin container with higher oxygen permeability T. Yuasa, H. Ohto, R. Yasunaga, T. Kai, N. Shirahama and T. Ogata Correspondence Gender-specific disease modification by NOS3 H. Grasemann and F. Ratjen Reply to ‘Gender-specific disease modification by NOS3’ K. Sharan, S. Surrey, S. K. Ballas, M. K. Borowski, M. Devoto, K.-F. Wang, E. Sandle1 and M. A. Keller Book Review Thomas’ Hematopoietic Stem Cell Transplantation G. Morgan Issue 2, July-II 2004 Images in Haematology Iliac giant pseudotumour in a haemophiliac patient R. Santoro, P. Ilannaccaro, G. Sottilotta and P. P. Arcuri Pulmonary calcinosis in adult T-cell leukaemia I. Miyoshi, T. Saito, M. Kobayashi and H. Taguchi Reviews Toward more effective antifungal therapy: the prospects of combination therapy D. P. Kontoyiannis and R. E. Lewis Fanconi anaemia and leukaemia — clinical and molecular aspects M. Tischkowitz and I. Dokal Haematological Malignancy Myeloma cells can directly contribute to the pool of RANKL in bone bypassing the classic stromal and osteoblast pathway of osteoclast stimulation F. P. L. Lai, M. Cole-Sinclair, W.-J. Cheng, J. M. W. Quinn, M. T. Gillespie, J. W. Sentr) and H.-G. Schneider Ocular presentation of primary central nervous system lymphoma: diagnosis and treatment A. Hormigo, L. Abrey, M.-H. Heinemann and L. M. DeAngelis Short report Haematogones in the peripheral blood of adults: a four-colour flow cytometry study of 102 patients S. H. Kroft, S. L. Asplund, R. W. McKenna and N. J. Karandikar Platelets, Haemostasis and Thrombosis Plasma levels of von Willebrand factor regulate ADAMTS-13, its major cleaving protease P. M. Mannucci, C. Capoferri and M. T. Canciani Identification of protein Sx gene mutations including four novel mutations in eight unrelated patients with protein S deficiency H. Okada, A. Takagi, T. Murate, T. Adachi, K. Yamamoto, T. Matsushita, J. Takamatsu, K. Sugita, M. Sugimoto, A. Yoshioka, T. Yamazaki, H. Saito and T. Kojima 6,7-Dihydroxy-3-phenylcoumarin inhibits thromboplastin induced disseminated intravascular coagulation I. Tunali, A. Yarat, M. Bulut and N. Emekli Haemopoiesis and Leucocytes Impact of pre-analytical handling on bone marrow mRNA gene expression S. Breit, M. Nees, U. Schaefer, M. Pfoersich, C. Hagemeier, M. Muckenthaler and A. E, Kulozik Synthesis of osteoprotegerin and RANKL by megakaryocytes is modulated by oestrogen S. Bord, E. Frith, D. C. Ireland, M. A. Scott, J. I. O. Craig and J. E. Compston Short report Neutrophil CD177 (NB1 gp, HNA-2a) expression is increased in severe bacterial infections and polycythaemia vera K. Gohring, J. Wolff, W. Doppl, K. L. Schmidt, K. Fenchel, H. Pralle, U. Sibelius and J. Bux Red Cells and Iron Direct interaction between the Lu/B-CAM adhesion glycoproteins and erythroid spectrin Y. Kroviarski, W. El Nemer, P. Gane, C. Rahuel, E. Gauthier, M. C. Lecomte, J. P. Cartron, Y. Colin and C. Le Van Kim Molecular basis of Japanese variants of pyrimidine 5’-nucleotidase deficiency H. Kanno, T. Takizawa, S. Miwa and H. Fujii Dehydrated hereditary stomatocytosis is associated with neonatal hepatitis D. C. Rees, B. Portmann, C. Ball, G. Mieli-Vergani, A. Nicolaou, M. C. Chetty and G. W. Stewart Transfusion Applications of murine and humanized chimaeric monoclonal antibodies for red cell phenotyping E. Lee, G. Burgess, G. R. Halverson, T. J]. Huang and M. E. Reid Correspondence Medical nemesis and childhood idiopathic thrombocytopenic purpura K. S. Charles, S. Chamely, A. Koppada, G. Perera, N. Johnson, S. Chawla and C. Pragassam Response to Charles et al J. Lilleyman Errata Issue 3, August-I 2004 Images in Haematology Spontaneous lesser sac haematoma in a haemophiliac N. Tsuchimochi and K. Nagafuji Volume Contents vi Calcineurin-inhibitor pain syndrome following haematopoietic stem cell transplantation A. Kida, K. Ohashi, C. Tanaka, N. Kamata, H. Akiyama and H. Sakamaki Reviews Advances in the molecular and serological diagnosis of invasive fungal infection in haemato-oncology patients L. A. McLintock and B. L. Jones P-selectin in haemostasis P. André Haematological Malignancy Complex chromosomal abnormalities in utero, 5 years before leukaemia Z. J. Broadfield, R. D. W. Hain, C. J. Harrison, G. Reza Jalali, M. McKinley, K. Michalova, H. M. Robinson, Z. Zemanova and M. Martineau Aberrant expression of f-catenin discriminates acute myeloid leukaemia from acute lymphoblastic leukaemia E. Serinséz, M. Neusch, G. Biische, R. von Wasielewski, H. Kreipe and O. Bock Classical and molecular cytogenetic abnormalities and outcome of childhood acute myeloid leukaemia: report from a referral centre in Israel B. Stark, M. Jeison, L. Glazer Gabay, J. Mardoukh, D. Luria, I. Bar-Am, G. Avrahami, Y. Kapeliushnik, D. Sthoeger, G. Herzel, D. M. Steinberg, I. J. Cohen, Y. Goshen, J. Stein, R. Zaizov and I. Yaniv Functional analysis of apoptosis induction in acute myeloid leukaemia-relevance of karyotype and clinical treatment response J. Braess, P. Schneiderat, C. Schoch, M. Fiegl, I. Lorenz and W. Hiddemann Serum free light chains for monitoring multiple myeloma G. P. Mead, H. D. Carr-Smith, M. T. Drayson, G. J. Morgan, J. A. Child and A. R. Bradwell The recurrent translocation t(14;20)(q32;q12) in multiple myeloma results in aberrant expression of MAFB: a molecular and genetic analysis of the chromosomal breakpoint G. R. Boersma-Vreugdenhil, J. Kuipers, E. van Stralen, T. Peeters, L. Michaux, A. Hagemeijer, P. L. Pearson, H. C. Clevers and B. J. E. G. Bast Bone marrow histological patterns can predict survival of patients with grade 1 or 2 follicular lymphoma: a study from the Groupe d‘Etude des Lymphomes Folliculaires D. Canioni, P. Brice, E. Lepage, M. Chababi, V. Meignin, B. Salles, L. Xerri, P.-Y. Peaud, P. Rousselot, M. Peuchmaur, P. Solal-Céligny and N. Brousse for The Groupe d’Etude des Lymphomes Folliculaires Transplantation Prospective evaluation of procalcitonin in adults with febrile neutropenia after haematopoietic stem cell transplantation M. Ortega, M. Rovira, X. Filella, M. Almela, J. Puig de la Bellacasa, E. Carreras and J. Mensa Haploidentical donor T cells fail to facilitate engraftment but lessen the immune response of host T cells in murine fetal transplantation J.-C. Chen, M.-L. Chang, H. Lee and M. O. Muench Platelets, Haemostasis and Thrombosis Resonance-thrombography indices of the haemostatic process in relation to risk of incident coronary heart disease: 9 years follow-up in the Caerphilly Prospective Heart Disease Study S. Yu, G. D. O. Lowe, J. W. G. Yarnell and P. M. Sweetnam Phenotypic sensitivity to activated protein C in healthy families: importance of genetic components and environmental factors C. Taralunga, R. Gueguen, S. Visvikis, V. Regnault, C. Sass, G. Siest, T. Lecompte and D. Wahl Efficacy and inhibitor development in previously treated patients with haemophilia A switched to a B domain-deleted recombinant factor VIII A. Gringeri, A. Tagliaferri, G. Tagariello, M. Morfini, E. Santagostino and P. Mannucci, the ReFacto—AICE Study Group Intraindividual consistency of the activated protein C resistance phenotype A. Tosetto, M. Simioni, D. Madeo and F. Rodeghiero Haemopoiesis and Leucocytes Human cytomegalovirus persists in myeloid progenitors and is passed to the myeloid progeny in a latent form S. F. Khaiboullina, J. P. Maciejewski, K. Crapnell, P. A. Spallone, A. D. Stock, G. S. Pari, E. D. Zanjani and S. St Jeor Disturbed flow promotes deposition of leucocytes from flowing whole blood in a model of a damaged vessel wall C. A. Skilbeck, P. G. Walker, T. David and G. B. Nash Red Cells and Iron Evidence of parvovirus B19 infection in patients of pre-eclampsia and eclampsia with dyserythropoietic anaemia S.-P. Yeh, C.-F. Chiu, C.-C. Lee, C.-T. Peng, C.-Y. Kuan and K.-C. Chow Short report Increased hepcidin expression and hypoferraemia associated with an acute phase response are not affected by inactivation of HFE D. M. Frazer, S. J. Wilkins, K. N. Millard, A. T. McKie, C. D. Vulpe and G. J. Anderson Correspondence Identification of a novel IGH-MMSET fusion transcript in a human myeloma cell line with the t(4;14)(p16-3;q32) chromosomal translocation D. Intini, S. Fabris, T. Storlazzi, T. Otsuki, G. Ciceri, D. Verdelli, L. Lombardi, M. Rocchi and A. Neri Book Review Nathan and Oski’s Hematoiogy of Infancy and Childhood, 6th edn. A. Vora Issue 4, August-II 2004 images in Haematology Cerebral mucormycosis in a patient with myelodysplastic syndrome taking corticosteroids A. Droll, F. Kunz, J. R. Passweg and M. Michot Volume Contents _ ix Tracing the origin of cytogenetic anomalies in acute myeloid leukaemia following multiple myeloma S. Georgia and H. Dieter-Kurt Review Hormones and pregnancy: thromboembolic risks for women J. L. Kujovich Guideline Guidelines for the diagnosis and management of hereditary spherocytosis P. H. B. Bolton-Maggs, R. F. Stevens, N. J. Dodd, G. Lamont, P. Tittensor and M.-J. King on behalf of the General Haematology Task Force of the British Committee for Standards in Haematology Haematological Malignancy Impaired osteoblastogenesis in myeloma bone disease: role of upregulated apoptosis by cytokines and malignant plasma cells F. Silvestris, P. Cafforio, N. Calvani and F. Dammacco High frequencies of chromosomal aberrations in multiple myeloma and monoclonal gammopathy of undetermined significance in direct chromosome preparation T. Nilsson, S. Lenhoff, L. Rylander, M. Héglund, I. Turesson, F. Mitelman, J. Westin and B. Johansson Translocations involving 6p22 in acute myeloid leukaemia at relapse: breakpoint characterization using microarray-based comparative genomic hybridization J. Tchinda, T. Dijkhuizen, P. van der Vlies, K. Kok and J. Horst In patients with myelodysplastic syndromes response to rHuEPO and G-CSF treatment is related to an increase of cytogenetically normal CD34" cells G. M. Rigolin, M. Della Porta, M. Ciccone, A. M. Bugli, L. Z. Bragotti, E. Mauro, C. Fraulini, A. R. Rossi, A. Bardi, A. Cuneo and G. Castoldi Short reports Low expression of the putative tumour suppressor gene gravin in chronic myeloid leukaemia, myelodysplastic syndromes and acute myeloid leukaemia J. Boultwood, A. Pellagatti, F. Watkins, L. J. Campbell, N. Esoof, N. C. P. Cross, H. Eagleton, T. J. Littlewood, C. Fidler and J. S. Wainscoat Autologous cytomegalovirus-specific T cells as effector cells in immunotherapy of B cell chronic lymphocytic leukaemia A. P. Kater, E. B. M. Remmerswaal, M. A. Nolte, E. Eldering, M. H. J. van Oers and R. A. W. van Lier Transplantation Tolerance associated with cord blood transplantation may depend on the state of host dendritic cells E. Liu, H. K. W. Law and Y.-L. Lau CD34" cell selection of peripheral blood progenitor cells using the CliniMACS device for allogeneic transplantation: clinical results in 102 patients M. Ringhoffer, M. Wiesneth, S. von Harsdorf, R. F. Schlenk, A. Schmitt, P. P. Reinhardt, M. Moessner, W. Grimminger, T. Mertens, S. N. Reske, H. Doéhner and D. Bunjes Improved haematopoietic recovery following transplantation with ex vivo-expanded mobilized blood cells H. M. Prince, P. J. Simmons, G. Whitty, D. P. Wall, L. Barber, G. C. Toner, J. F. Seymour, G. Richardson, R. Mrongovius and D. N. Haylock x Volume Contents Platelets, Haemostasis and Thrombosis Compound heterozygous mutations in the y-glutamyl carboxylase gene cause combined deficiency of all vitamin K-dependent blood coagulation factors S. Rost, A. Fregin, D. Koch, M. Compes, C. R. Miiller and J. Oldenburg Activated protein C levels in Behcet’s disease and risk of venous thrombosis S. Navarro, J. M. Ricart, P. Medina, A. Vaya, P. Villa, J. Todoli, A. Estellés, M. L. Mico, J. Aznar and F. Espana The value of education and self-monitoring in the management of warfarin therapy in older patients with unstable control of anticoagulation T. I. Khan, F. Kamali, P. Kesteven, P. Avery and H. Wynne Effects of genetic fusion of factor IX to albumin on in vivo clearance in mice and rabbits W. P. Sheffield, A. Mamdani, G. Hortelano, S. Gataiance, L. Eltringham-Smith, M. E. Begbie, R. A. Leyva, P. S. Liaw and F. A. Ofosu Haemopoiesis and Leucocytes Novel 2’-substituted, 3’-deoxy-phosphatidyl-myo-inositol analogues reduce drug resistance in human leukaemia cell lines with an activated phosphoinositide 3-kinase/Akt pathway G. Tabellini, P. L. Tazzari, R. Bortul, A. M. Billi, R. Conte, L. Manzoli, L. Cocco and A. M. Martelli Human T cells as mediators of chimeric-receptor redirected anti-tumour immunity M. Rischer, S. Pscherer, S. Duwe, J. Vormoor, H. Jiirgens and C. Rossig Dendritic cells fused with core binding factor-beta positive acute myeloid leukaemia blast cells induce activation of cytotoxic lymphocytes G.-A. Banat, N. Usluoglu, M. Hoeck, K. Ihlow, S. Hoppmann and H. Pralle Short report A single, multiplex analysis for all relevant activating NRAS gene mutations using heteroduplex generators C. Belli, D. J. Bowen, C. De Brasi and I. Larripa Red Cells and Iron Are there clinical phenotypes of homozygous sickle cell disease? N. Alexander, D. Higgs, G. Dover and G. R. Serjeant Rapamycin-mediated induction of y-globin mRNA accumulation in human erythoid cells C. Mischiati, A. Sereni, I. Lampronti, N. Bianchi, M. Borgatti, E. Prus, E. Fibach and R. Gambari Correspondence Immune thrombocytopenic purpura: investigation of the role of cytomegalovirus infection A. S. Levy and J. Bussel Successful reduced-intensity allogeneic transplantation utilizing a fludarabine- based preparative regimen in a patient with chronic lymphocytic leukaemia and a history of fludarabine-associated autoimmune haemolytic anaemia C. D. Ford, J. Asch, M. Pulsipher and F. Bo Petersen Erratum