Table Of Content

Volume Contents iii BRITISH JOURNAL OF HAEMATOLOGY Volume 117, Issue 1, April 2002 IMAGES IN HAEMATOLOGY Mantle cell lymphoma in leukaemic phase R. J. Lush, D. P. Sowter and A. P. Haynes Cyclophosphamide-induced nail pigmentation M. Srikanth, J. Van Veen, A. Raithatha and J. T. Reilly HISTORICAL REVIEW Historical aspects of paroxysmal nocturnal haemoglobinuria: ‘defining the disease’ C. J. Parker REVIEW Immunomodulatory gene therapy for haematological malignancies G. D. Schmidt-Wolf and I. G. H. Schmidt-Wolf HAEMATOLOGICAL MALIGNANCY Results of treatment of children with refractory anaemia with excess blasts (RAEB) and RAEB in transformation (RAEBt) in Great Britain 1990-99 D. K. H. Webb, S. J. Passmore, I. M. Hann, G. Harrison, K. Wheatley and ]. M. Chessells Effect of fluconazole prophylaxis on fungal blood cultures: an autopsy-based study involving 720 patients with haematological malignancy M. Kami, U. Machida, K. Okuzumi, T. Matsumura, S.-i. Mori, A. Hori, T. Kashima, Y. Kanda, Y. Takaue, H. Sakamaki, H. Hirai, A. Yoneyama and Y. Mutou Serum erythropoietin values in erythrocytoses and in primary thrombocythaemia M. Messinezy, N. B. Westwood, I. El-Hemaidi, J. T. Marsden, R. S. Sherwood and T. C. Pearson Prognostic value of soluble interleukin 2 receptor levels in Langerhans cell histiocytosis D. A. Rosso, A. Roy, M. Zelazko and J. L. Braier Co-expression of CD30 ligand and interleukin 4 (IL-4) receptors by acute myeloid leukaemia blasts is associated with the expansion of IL-4-producing CD30~ normal T cells F. M. Rossi, M. Degan, F. T. Mazzocco, R. Di Francia, D. Aldinucci, D. Poletto, E. Vellenga, A. Pinto and V. Gattei iv Volume Contents Magnetic resonance imaging of femoral marrow predicts outcome in adult patients with acute myeloid leukaemia in complete remission S. Takagi and O. Tanaka Differentiation of promyelocytic leukaemia: alterations in Fas (CD95/Apo-1) and Fas Ligand (CD178) expression H. R. Salih, G. C. Starling, S. F. Brandl, R. Pelka-Fleischer, T. Haferlach, W. Hiddemann, P. A. Kiener and V. Nuessler RANK (receptor activator of nuclear factor-kB) and RANKL expression in multiple myeloma S. Roux, V. Meignin, J]. Quillard, G. Meduri, A. Guiochon-Mantel, J.-P. Fermand, E. Milgrom and X. Mariette Enhanced antitumoral effectiveness of idiotype vaccination induced by the administration of Fit3 ligand combined with interleukin 2 against a murine myeloma M. Zeis, T. Zunkel, J. Steinmann, N. Schmitz and L. Uharek Myeloma of the central nervous system: association with high-risk chromosomal abnormalities, plasmablastic morphology and extramedullary manifestations A. B.-T. Fassas, F. Muwalla, T. Berryman, R. Benramdane, L. Joseph, E. Anaissie, R. Sethi, R. Desikan, D. Siegel, A. Badros, A. Toor, M. Zangari, C. Morris, E. Angtuaco, S. Mathew, C. Wilson, A. Hough, S. Harik, B. Barlogie and G. Tricot Influence of karyotype on outcome of allogeneic bone marrow transplantation for adults with precursor B-lineage acute lymphoblastic leukaemia in first or second remission S. Lee, D.-W. Kim, Y.-]. Kim, Y.-H. Park, C.-K. Min, J.-W. Lee, W.-S. Min and C.-C. Kim A pilot study of the recombinant soluble human tumour necrosis factor receptor (p75)-Fe fusion protein in patients with myelodysplastic syndrome ]. P. Maciejewski, A. M. Ristiano, E. M. Sloand, L. Wisch, N. Geller, J. A. Barrett and N. S. Young Short reports Epstein-Barr virus-associated T-cell acute lymphoblastic leukaemia S. Sakajiri, K. Mori, Y. Isobe, N. Kawamata and K. Oshimi Combined arsenic trioxide and all-trans retinoic acid treatment for acute promyelocytic leukaemia recurring from previous relapses successfully treated using arsenic trioxide W. Y. Au, C. S. Chim, A. K. W. Lie, R. Liang and Y. L. Kwong Fluoro-deoxyglucose positron emission tomography imaging for the detection of occult disease in multiple myeloma K. Orchard, S. Barrington, J. Buscombe, A. Hilson, H. G. Prentice and A. Mehta PLATELETS, HAEMOSTASIS AND THROMBOSIS Factor VIII inhibitor in a patient with mild haemophilia A and an Asn°'*® > Ser mutation responsive to immune tolerance induction and cyclophosphamide A. J. Vlot, S. Wittebol, P. F. W. Strengers, E. A. M. Turenhout, J. Voorberg, H. M. van den Berg and E. P. Mauser-Bunschoten Semiquantitative measurement of IgG subclasses and IgM of platelet-specific antibodies in a glycoprotein-specific platelet—antigen capture assay R. Kelsch, K. Hutt, U. Cassens and W. Sibrowski Volume Contents v Regulation of plasminogen activator inhibitor-1 secretion by urokinase and tissue plasminogen activator in rat epithelioid-type smooth muscle cells H. K. F. Lau and J. Ho Age, sex and vitamin status affect plasma level of homocysteine, but hyperhomocysteinaemia is possibly not an important risk factor for venous thrombophilia in Taiwanese Chinese J.-S. Lin, M.-C. Shen, W.-C. Cheng, W. Tsay, Y.-C. Wang, B.-B. Lin and M.-H. Hung Short reports Immunocytochemistry for the heavy chain of the non-muscle myosin IIA as a diagnostic tool for MYH9-related disorders A. Pecci, P. Noris, R. Invernizzi, A. Savoia, M. Seri, G. M. Ghiggeri, S. Sartore, S. Gangarossa, N. Bizzaro and C. L. Balduini Characterization of two novel splice site mutations in human factor VII gene causing severe plasma factor VII deficiency and bleeding diathesis K. Borensztajn, O. Chafa, M. Alhenc-Gelas, S. Salha, A. Reghis, A.-M. Fischer and ]. Tapon-Bretaudiére Inherited factor VII deficiency and surgery: clinical data are the best criteria to predict the risk of bleeding M. Giansily-Blaizot, C. Biron-Andreani, P. Aguilar-Martinez, P. de Moeloose, M. E. Briquel, J. Goudemand, N. Stieltjes, C. Barrot, H. Chambost, A. Durin, V. Gay, J. Peynet, K. Pouymayou and J.-F. Schved HAEMOPOIESIS AND LEUCOCYTES Reversion of autoimmune lymphoproliferative syndrome with an antimalarial drug: preliminary results of a clinical cohort study and molecular observations J. van der Werff ten Bosch, P. Schotte, A. Ferster, N. Azzi, T. Boehler, G. Laureys, M. Arola, C. Demanet, R. Beyaert, K. Thielemans and J. Otten Short report 189 Abnormal telomere shortening in leucocytes of children with Shwachman—- Diamond syndrome I. Thornley, Y. Dror, L. Sung, R. F. Wynn and M. H. Freedman RED CELLS Enhanced haemolysis with B-thalassaemia trait due to the unstable B chain variant, Hb Gunma, accompanied by hereditary elliptocytosis due to protein 4-1 deficiency in a Japanese family T. Maehara, N. Tsukamoto, Y. Nojima, M. Karasawa, H. Murakami, Y. Hattori and H. Ideguchi Gastroduodenal lesions in polycythaemia vera: frequency and role of Helicobacter pylori G. Torgano, C. Mandelli, P. Massaro, C. Abbiati, A. Ponzetto, G. Bertinieri, S. F. Bogetto, E. Terruzzi and R. de Franchis Assignment of functional roles to parasite proteins in malaria-infected red blood cells by competitive flow-based adhesion assay B. M. Cooke, F. K. Glenister, N. Mohandas and R. L. Coppel Short report Familial pseudohyperkalaemia Cardiff: a mild version of cryohydrocytosis D. M. Gore, M. C. Chetty, J. Fisher, A. Nicolaou and G. W. Stewart vi Volume Contents TRANSFUSION An estimate of the current risk of transmitting blood-borne infections through blood transfusion in Italy M. E. Tosti, S. Solinas, D. Prati, L. Salvaneschi, M. Manca, M. Francesconi, M. Ciuffreda, G. Girelli and A. Mele Heterozygosity for two novel null alleles of the KEL gene causes the Kell-null phenotype in a Japanese woman Y. Koda, M. Soejima, M. Tsuneoka, K. Yasumoto, T. Higashitani, K. Sagawa and H. Kimura TRANSPLANTATION Selective in vitro expansion and efficient retroviral transduction of human CD34~ CD38 haematopoietic stem cells Y. Y. Ng, A. C. Bloem, B. van Kessel, H. Lokhorst, T. Logtenberg and F. J. T. Staal CD34*/CD90° cells infused best predict late haematopoietic reconstitution following autologous peripheral blood stem cell transplantation T. Sumikuma, C. Shimazaki, T. Inaba, N. Ochiai, A. Okano, M. Hatsuse, E. Ashihara and M. Nakagawa Short report Syngeneic stem cell transplant for spent-phase polycythaemia vera: eradication of myelofibrosis and restoration of normal haematopoiesis S. Richard, L. Isola, E. Scigliano, H. Singh, V. Najfeld, H. Gilbert, R. S. Weinberg and S. Fruchtman CORRESPONDENCE A survey of one-stage and chromogenic potencies in therapeutic factor VIII concentrates A. R. Hubbard, L. J. Weller and S. A. Bevan Complete, long-term remission of refractory idiopathic cold haemagglutinin disease after Mabthera M. Gharib and C. Poynton A case of severe refractory thrombotic thrombocytic purpura responding to treatment with 13-Cis retinoic acid M. Gorner, R. Seggewiss, T. Schlenker, W. Stremmel and A. D. Ho Chronic relapsing thrombotic thrombocytopenic purpura due to a deficiency of von Willebrand factor-cleaving protease activity G. L. Stark, J. P. Wallis, S. L. Allford and J. Hanley Phenotyping primitive plasma cells D. Joshua, B. Pope, R. Brown, L. Barrow, A. Murray and J. Gibson Levels of von Willebrand factor-cleaving protease are normal in methylene blue-treated fresh-frozen plasma R. Cardigan, S. Allford and L. Williamson BOOK REVIEW ANNOUNCEMENT Volume Contents Vii Volume 117, Issue 2, May 2002 IMAGES IN HAEMATOLOGY Cutaneous reaction to low-molecular-weight heparin M. Sivakumaran and K. Ghosh Anaplastic large cell lymphoma of the parietal bone S. Biasotti, P. Fondelli and A. Garaventa ANNOTATION Impaired gut function as risk factor for invasive candidiasis in neutropenic patients N. M. A. Blijlevens, J. P. Donnelly and B. E. de Pauw HISTORICAL REVIEW The spleen B. S. Wilkins REVIEW Transfusion-associated graft-versus-host disease M. L. Schroeder HAEMATOLOGICAL MALIGNANCY Thalidomide treatment in myelofibrosis with myeloid metaplasia M. A. Elliott, R. A. Mesa, C.-Y. Li, C. C. Hook, S. M. Ansell, R. M. Levitt, S. M. Geyer and A. Tefferi Optimizing dendritic cell-based immunotherapy in multiple myeloma Q. Yi, R. Desikan, B. Barlogie and N. Munshi Treatment of infants with lymphoblastic leukaemia: results of the UK Infant Protocols 1987-1999 ]. M. Chessells, C. J. Harrison, S. L. Watson, A. J. Vora and S. M. Richards for the Medical Research Council Working Party on Childhood Leukaemia Low frequency of clonotypic Ig and T-cell receptor gene rearrangements in t(4;11) infant acute lymphoblastic leukaemia and its implication for the detection of minimal residual disease M. Peham, S. Panzer, K. Fasching, O. A. Haas, S. Fischer, R. Marschalek, H. Gadner and E. R. Panzer-Griimayer Rearrangement of the BCL6 locus at 3q27 is an independent poor prognostic factor in nodal diffuse large B-cell lymphoma S. L. Barrans, S. J. M. O'Connor, P. A. S. Evans, F. E. Davies, R. G. Owen, A. P. Haynes, G. J. Morgan and A. S. Jack Vill Volume Contents Liposomal encapsulation diminishes daunorubicin-induced generation of reactive oxygen species, depletion of ATP and necrotic cell death in human leukaemic cells F.-T. Liu, S. M. Kelsey, A. C. Newland and L. Jia In vitro and in vivo effectiveness of arsenic trioxide against murine T-cell prolymphocytic leukaemia C. Récher, M. Chopin, E. Raffoux, G. Pierron, J. Poupon, F. Sigaux, H. Dombret and M.-H. Stern Abdominal infections in patients with acute leukaemia: a prospective study applying ultrasonography and microbiology M. Gorschliiter, G. Marklein, K. Héfling, R. Clarenbach, S. Baumgartner, C. Hahn, C. Ziske, U. Mey, R. Heller, A. M. Eis-Hiibinger, T. Sauerbruch, I. G. H. Schmidt-Wolf and A. Glasmacher High level of microsatellite instability but not hypermethylation of mismatch repair genes in therapy-related and secondary acute myeloid leukaemia and myelodysplastic syndrome M. H. Sheikhha, K. Tobal and J. A. Liu Yin Expression pattern of MUM1/IRF4 in the spectrum of pathology of Hodgkin's disease A. Carbone, A. Gloghini, D. Aldinucci, V. Gattei, R. Dalla-Favera and G. Gaidano A novel cell line derived from de novo acute myeloblastic leukaemia with trilineage myelodysplasia which proliferates in response to a Notch ligand, Delta-1 protein S. Tohda, S. Sakano, M. Ohsawa, N. Murakami and N. Nara Pneumocystis carinii pneumonia in patients with malignant haematological diseases: 10 years’ experience of infection in GIMEMA centres L. Pagano, L. Fianchi, L. Mele, C. Girmenia, M. Offidani, P. Ricci, M. E. Mitra, M. Picardi, C. Caramatti, P. Piccaluga, A. Nosari, M. Buelli, B. Allione, A. Cortelezzi, F. Fabbiano, G. Milone, R. Invernizzi, B. Martino, L. Masini, G. Todeschini, M. A. Cappucci, D. Russo, L. Corvatta, P. Martino and A. Del Favero Short report Interleukin 6 and tumour necrosis factor alpha serum levels in monoclonal gammopathy of undetermined significance ]. Blade, X. Filella, S. Montoto, F. Bosch, L. Rosinol, F. Coca, E. Giné, E. Nadal, M. Aymerich, M. Rozman and E. Montserrat PLATELETS, HAEMOSTASIS AND THROMBOSIS Three parameters, plasma thrombopoietin levels, plasma glycocalicin levels and megakaryocyte culture, distinguish between different causes of congenital thrombocytopenia S. van den Oudenrijn, M. Bruin, C. C. Folman, J. Bussel, M. de Haas and A. E. G. Kr. von dem Borne Mean platelet volume is an independent risk factor for myocardial infarction but not for coronary artery disease G. Endler, A. Klimesch, H. Sunder-Plassmann, M. Schillinger, M. Exner, C. Mannhalter, N. Jordanova, G. Christ, R. Thalhammer, K. Huber and R. Sunder-Plassmann Human platelet antigen 1 (HPA 1) genotyping with 5’ nuclease assay and sequence-specific primers reveals a single nucleotide deletion in intron 2 of the HPA la allele of platelet glycoprotein IIIa K. M. Kjaer, S. Jaegtvik, A. Husebekk and B. Skogen Volume Contents ix Red blood cells from patients with homozygous sickle cell disease provide a catalytic surface for factor Va inactivation by activated protein C A. Bezeaud, L. Venisse, D. Helley, C. Trichet, R. Girot and M.-C. Guillin Cell-specific abnormal prenylation of Rab proteins in platelets and melanocytes of the gunmetal mouse Q. Zhang, L. Zhen, W. Li, E. K. Novak, L. M. Collinson, E. K. Jang, R. J. Haslam, R. W. Elliott and R. T. Swank Short report 424 Flow cytometry analysis of platelet cyclooxygenase-2 expression: induction of platelet cyclooxygenase-2 in patients undergoing coronary artery bypass grafting A.-A. Weber, B. Przytulski, M. Schumacher, N. Zimmermann, E. Gams, T. Hohifeld and K. Schrér HAEMOPOIESIS AND LEUCOCYTES Translocations of 14q32 and deletions of 13q14 are common chromosomal abnormalities in systemic amyloidosis C. J. Harrison, H. Mazzullo, F. M. Ross, K. L. Cheung, G. Gerrard, L. Harewood, A. Mehta, H. J. Lachmann, P. N. Hawkins and K. H. Orchard RED CELLS Short reports Effect of VDR polymorphisms on growth and bone mineral density in homozygous beta thalassaemia M. Ferrara, S. M. R. Matarese, M. Francese, B. Borrelli, A. Coppola, L. Coppola and L. Esposito Belated diagnosis in three patients with rifampicin-induced immune haemolytic anaemia N. Ahrens, R. Genth and A. Salama TRANSPLANTATION Early and late invasive pneumococcal infection following stem cell transplantation: a European Bone Marrow Transplantation survey D. Engelhard, C. Cordonnier, P. J. Shaw, T. Parkalli, C. Guenther, R. Martino, A. W. Dekker, H. G. Prentice, A. Gustavsson, W. Nurnberger and P. Ljungman on behalf of the Infectious Disease Working Party of the European Bone Marrow Transplantation (IDWP-EBMT) Economics, health care systems and utilization of haematopoietic stem cell transplants in Europe A. Gratwohl, J. Passweg, H. Baldomero, B. Horisberger and A. Urbano-Ispizua for the Accreditation Committee of the European Group for Blood and Marrow Transplantation (EBMT) Factor XIII activity levels in patients with allogeneic haematopoietic stem cell transplantation and acute graft-versus-host disease of the gut R. Pihusch, C. Salat, P. Géhring, M. Hentrich, H. Wegner, M. Pihusch, E. Hiller, H.-J. Kolb and H. Ostermann Short report Cultured autografting for juvenile myelomonocytic leukaemia J. D. Grainger, A. M. Will and R. F. Stevens Volume Contents CORRESPONDENCE Prophylactic treatment with fresh-frozen plasma in chronic thrombotic thrombocytopenic purpura M. Sivakumaran and J. Roland Childhood refractory autoimmune haemolytic anaemia: is there a role for anti-CD20 therapy (rituximab)? C. Mc Mahon, L. Babu, A. Hodgson, A. Hayat, N. O. Connell and O. P. Smith Treatment of severe fetomaternal alloimmune thrombocytopenia with compatible frozen—thawed platelet concentrates K. Lee, F. Beaujean and P. Bierling ANNOUNCEMENT ERRATA Volume 117, Issue 3, June-I 2002 IMAGES IN HAEMATOLOGY Chronic myeloid leukaemia in megakaryocytic crisis S. Ranjitkumar and R. Lindeman Hyposplenism after allogeneic bone marrow transplantation W. Y. Au, S. K. Ma and K. K. Wong REVIEW Receptor tyrosine kinase mutations in myeloid neoplasms R. Gupta, C. L. Knight and B. J. Bain ANNOTATION Air travel and thrombosis P. L. F. Giangrande HAEMATOLOGICAL MALIGNANCY Congenital leukaemia: the Dutch experience and review of the literature D. Bresters, A. C. W. Reus, A. J. P. Veerman, E. R. van Wering, A. van der Does-van den Berg and G. J. L. Kaspers Expression of the Ikaros gene family in childhood acute lymphoblastic leukaemia M. Takanashi, T. Yagi, T. Imamura, Y. Tabata, A. Morimoto, S. Hibi, E. Ishii and S. Imashuku Volume Contents xi The absence of the p15'‘**" gene alterations in adult patients with precursor B-cell acute lymphoblastic leukaemia is a favourable prognostic factor K. Hoshino, N. Asou, T. Okubo, H. Suzushima, T. Kiyokawa, F. Kawano and H. Mitsuya Allele and haplotype frequency at human leucocyte antigen class I/II and immunomodulatory cytokine loci in patients with myelodysplasia and acute myeloid leukaemia: in search of an autoimmune aetiology D. Gowans, A. O'Sullivan, S. Rollinson, P. Roddam, M. Groves, C. Fegan, G. Morgan and D. Bowen Epstein-Barr virus (EBV)-positive pyothorax-associated lymphoma (PAL): chromosomal integration of EBV in a novel CD2-positive PAL B-cell line M. Daibata, T. Taguchi, Y. Nemoto, T. Saito, H. Machida, S. Imai, I. Miyoshi and H. Taguchi Trisomy 3 in two paediatric post-transplant lymphomas M. S. Gallego, A. Bernasconi, M. T. Davila, A. Rampazzi, G. Chantada, G. Gallo, J. Rossi and C. Z. Barreiro In vitro evaluation of the efficacy of idarubicin in human tumour cells from patients with low-grade non-Hodgkin's lymphoma A. Aleskog, E. Jonsson, R. Larsson, P. Nygren, J. Kristensen, C. Sundstrém and M. Héglund The stromal composition of malignant lymphoid aggregates in bone marrow: variations in architecture and phenotype in different B-cell tumours F. Vega, L. J. Medeiros, W.-H. Lang, A. Mansoor, C. Bueso-Ramos and D. Jones Effect of inositol hexaphosphate (IP,,) on human normal and leukaemic haematopoietic cells G. Lambertenghi Deliliers, F. Servida, N. S. Fracchiolla, C. Ricci, C. Borsotti, G. Colombo and D. Soligo p53 expression in K562 cells is associated with caspase-mediated cleavage of c-ABL and BCR-ABL protein kinases A. M. A. Di Bacco and T. G. Cotter The predictive value of clonogenic stem cell assays for the diagnosis of polycythaemia vera C. Zwicky, L. Theiler, K. Zbaren, E. Ischi and A. Tobler Dose escalation therapy in previously untreated patients with multiple myeloma following Z-Dex induction treatment A. D. Clark, K. W. Douglas, L. D. Mitchell, I. G. McQuaker, A. N. Parker, P. J. Tansey, I. M. Franklin and G. Cook Short reports Therapy-related chronic myelogenous leukaemia following autologous stem cell transplantation for Ewing’s sarcoma A. Numata, K. Shimoda, H. Gondo, K. Kato, K. Aoki, Y. Ito, K. Takase, Y. Asano, T. Okamura, Y. Niho and M. Harada Deletion of sequences flanking the t(9;22) breakpoint: a secondary genetic event associated with loss of cytogenetic response to interferon in a Philadelphia-positive chronic myeloid leukaemia patient E. Arranz, J. J. Gil-Fernandez, S. Ramiro, C. Blas, M. Renedo, A. Alegre, A. Escudero and J. M. Fernandez-Ranada Stevens—Johnson syndrome after treatment with STI571: a case report L.-T. Hsiao, H.-M. Chung, J.-T. Lin, T.-]. Chiou, J.-H. Liu, F. S. Fan, W.-S. Wang, C.-C. Yen and P.-M. Chen Low concentrations of STI571 in the cerebrospinal fluid: a case report A. L. Petzer, E. Gunsilius, M. Hayes, G. Stockhammer, H. Ch. Duba, F. Schneller, K. Griinewald, W. Poewe and G. Gastl FGFR3 dysregulation in multiple myeloma: frequency and prognostic relevance T. Rasmussen, H. R. Hudlebusch, L. M. Knudsen and H. E. Johnsen xii Volume Contents TRANSPLANTATION Early lymphocyte recovery post-autologous haematopoietic stem cell transplantation is associated with better survival in Hodgkin's disease L. F. Porrata, D. J. Inwards, I. N. Micallef, S. M. Ansell, S. M. Geyer and S. N. Markovic Human leucocyte antigen alloimmunization after bone marrow transplantation: an association with chronic myelogenous leukaemia T. L. Geiger, P. Woodard, X. Tong, D. K. Srivastava, R. Johnson, V. Turner, G. Hale and S. Richardson Short reports Qualitative and quantitative polymerase chain reaction detection of the residual myeloma cell contamination after positive selection of CD34* cells with small- and large-scale Miltenyi cell sorting system C. Voena, G. Locatelli, C. Castellino, P. Omede, M. Ladetto, E. Zappone, R. Milani, V. Perfetti, M. Boccadoro, A. Pileri, P. Lusso, C. Villa, M. Malnati and P. Corradini The endogenous granulocyte colony-stimulating factor response following autologous peripheral blood stem cell transplantation is impaired in patients with myeloma T. C. M. Morris, M. K. Magill, M. Drake, S. Price, L. Ranaghan, S. Bridget, A. E. Jordan and A. E. Irvine PLATELETS, HAEMOSTASIS AND THROMBOSIS Reduced platelet adhesion in flowing blood to fibrinogen by alterations in segment y316-322, part of the fibrin-specific region ]. A. Remijn, M. J. W. Ijsseldijk, B. M. van Hemel, D. K. Galanakis, K. A. Hogan, K. C. Lounes, S. T. Lord, J. J. Sixma and P. G. de Groot Effects of desmopressin on thrombogenesis in aspirin-induced platelet dysfunction F. W. Peter, C. Benkovic, T. Muehlberger, P. M. Vogt, H. H. Homann, C. Kuhnen, A. Wiebalck and H. U. Steinau Roles for both cyclic GMP and cyclic AMP in the inhibition of collagen-induced platelet aggregation by nitroprusside E. K. Jang, J. E. Azzam, N. T. Dickinson, M. M. L. Davidson and R. J. Haslam Low levels of activated protein C in patients with systemic lupus erythematosus do not relate to lupus anticoagulants but to low levels of factor II M. J. A. Simmelink, J. A. Fernandez, R. H. W. M. Derksen, J. H. Griffin and P. G. de Groot Gene mutations and three-dimensional structural analysis in 13 families with severe factor X deficiency F. Peyvandi, M. Menegatti, E. Santagostino, S. Akhavan, J. Uprichard, D. J. Perry, S. J. Perkins and P. M. Mannucci Tissue factor and tissue factor pathway inhibitor levels in unstable angina patients during short-term low-molecular-weight heparin administration A. M. Gori, S. Fedi, G. Pepe, M. Falciani, A. Rogolino, D. Prisco, G. F. Gensini and R. Abbate Antithrombotic effect of PMC, a potent «-tocopherol analogue on platelet plug formation in vivo G. Hsiao, M. H. Yen, Y. M. Lee and J.-R. Sheu Short reports On the mechanism of action of recombinant activated factor VII administered to patients with severe thrombocytopenia and life-threatening haemorrhage: focus on prothrombin activation G. T. Gerotziafas, K. Zervas, P. Arzoglou, E. Karavaggeli, S. Parashou, P. Van Dreden, ]. Christakis and M. M. Samama