Table Of Content

Volume Contents BRITISH JOURNAL OF HAEMATOLOGY Volume 112, Issue 1, January 2001 IMAGES IN HAEMATOLOGY Red swollen nail folds and nail deformity as presenting findings in chronic lymphocytic leukaemia M. Yagc1, G. T. Sucak and R. Haznedar Primary malignant ocular melanoma: a bone marrow diagnosis C. S. Chim and N. J. Trendell Smith HISTORICAL REVIEW The emerging understanding of sickle cell disease G. R. Serjeant REVIEWS The panoply of animal models for sickle cell anaemia R. L. Nagel and M. E. Fabry Acquired antithrombin deficiency in sepsis B. White and D. Perry ERYTHROCYTES AND IRON Neonatal screening for haemoglobinopathies: the results of a 10-year programme in an English Health Region A. M. Almeida, J. S. Henthorn and S. C. Davies Bone resorption is increased in young adults with thalassaemia major E. Voskaridou, M.-C. Kyrtsonis, E. Terpos, M. Skordili, I. Theodoropoulos, A. Bergele, E. Diamanti, A. Kalovidouris, A. Loutradi and D. Loukopoulos Clinical and molecular evaluation of non-dominant hereditary spherocytosis E. Miraglia del Giudice, B. Nobili, M. Francese, L. D’Urso, A. Iolascon, S. Eber and S. Perrotta Short reports Membrane-bound iron contributes to oxidative damage of B-thalassaemia intermedia erythrocytes D. Tavazzi, L. Duca, G. Graziadei, A. Comino, G. Fiorelli and M. D. Cappellini Denaturing gradient gel electrophoresis screening for mutations in the hereditary hyperferritinaemia cataract syndrome M. Giansily, C. Beaumont, C. Desveaux, G. Hetet, J.-E Schved and P. Aguilar-Martinez LEUCOCYTES Characteristics of leucocyte adhesion directly observed in flowing whole blood in vitro K. B. Abbitt and G. B. Nash Short report Formation of non-resorbing osteoclasts from peripheral blood mononuclear cells of patients with malignant juvenile osteopetrosis M. H. Helfrich and E. J. A. Gerritsen Volume Contents PLATELETS, HAEMOSTASIS AND THROMBOSIS Anti-PF4—heparin immunoglobulin G is the major class of heparin-induced thrombocytopenia antibody: findings of an enzyme-linked immunofiltration assay using membrane-bound hPF4—heparin C. M. Vun, S. Evans and C. N. Chesterman Missense C168T in the Wiskott—Aldrich Syndrome protein gene is a common mutation in X-linked thrombocytopenia L. L. Ho, J. Ayling, I. Prosser, H. Kronenberg, H. Iland and D. Joshua Elevated endothelial microparticles in thrombotic thrombocytopenic purpura: findings from brain and renal microvascular cell culture and patients with active disease J. J. Jimenez, W. Jy, L. M. Mauro, L. L. Horstman and Y. S. Ahn Treatment of coagulation inhibitors with extracorporeal immunoadsorption (Ig-Therasorb) M. Jansen, S. Schmaldienst, S. Banyai, P. Quehenberger, I. Pabinger, K. Derfler, W. H. Hérl and P. Knobl Tissue factor activity in human monocytes is regulated by plasma: implications for the high and low responder phenomenon M. Nijziel, R. van Oerle, C. van ‘t Veer, E. van Pampus, T. Lindhout and K. Hamulyak Short report Identification of a new mutation in platelet glycoprotein IX (GPIX) in a patient with Bernard—Soulier syndrome C. E. Rivera, J. Villagra, M. Riordan, S. Williams, K. J. Lindstrom and M. E. Rick HAEMATOLOGICAL MALIGNANCY Clinical and biological features of acute myeloid leukaemia occurring as second malignancy: GIMEMA archive of adult acute leukaemia L. Pagano, A. Pulsoni, M. E. Tosti, G. Avvisati, L. Mele, A. Mele, B. Martino, G. Visani, R. Cerri, E. Di Bona, R. Invernizzi, A. Nosari, M. Clavio, B. Allione, P. Coser, A. Candoni, A. Levis, A. Camera, L. Melillo, G. Leone and E Mandelli for the GIMEMA Patients with de novo acute myeloid leukaemia and complex karyotype aberrations show a poor prognosis despite intensive treatment: a study of 90 patients C. Schoch, T. Haferlach, D. Haase, C. Fonatsch, H. Léffler, B. Schlegelberger, P. Staib, M. C. Sauerland, A. Heinecke, T. Btichner and W. Hiddemann for the German AML Cooperative Study Group A multicentre, open, non-comparative phase II study of a combination of fludarabine phosphate, cytarabine and granulocyte colony-stimulating factor in relapsed and refractory acute myeloid leukaemia and de novo refractory anaemia with excess of blasts in transformation G. Jackson, P. Taylor, G. M. Smith, R. Marcus, A. Smith, P. Chu, T. J. Littlewood, A. Duncombe, M. Hutchinson, A. B. Mehta, S. A. Johnson, P. Carey, M. J. Mackie, P. S. Ganly, G. E. Turner, M. Deane, S. Schey, J. Brookes, S. M. Tollerfield and M. P. Wilson Identification and characterization of a novel gene that is upregulated in leukaemia cells by nitric oxide P. J. Shami, N. Kanai, L. Y. Wang, T. M. Vreeke and C. J. Parker Methylation of the p15'‘**8 gene in myelodysplastic syndrome: it can be detected early at diagnosis or during disease progression and is highly associated with leukaemic transformation H.-E Tien, J.-L. Tang, W. Tsay, M.-C. Liu, E-Y. Lee, C.-H. Wang, Y.-C. Chen and M.-C. Shen Volume Contents V Interleukin 4 therapy for patients with chronic lymphocytic leukaemia: a phase I/II study J. Lundin, E. Kimby, L. Bergmann, T. Karakas, H. Mellstedt and A. Osterborg B-lymphotropic viruses in a novel tropical splenic lymphoma I. Bates, G. Bedu-Addo, R. F. Jarrett, T. Schulz, S. Wallace, A. Armstrong, J. Sheldon and T. Rutherford Multicolour spectral karyotyping identifies new translocations and a recurring pathway for chromosome loss in multiple myeloma J. R. Sawyer, J. L. Lukacs, E. L. Thomas, C. M. Swanson, L. S. Goosen, G. Sammartino, J. C. Gilliland, N. C. Munshi, G. Tricot, J. D. Shaughnessy Jr and B. Barlogie The combination of oral amphotericin B with azoles prevents the emergence of resistant Candida species in neutropenic patients P. J. Paterson, PR H. M. McWhinney, M. Potter, C. C. Kibbler and H. G. Prentice Selective enhancement of thrombopoietic activity of PEGylated interleukin 6 by a simple procedure using a reversible amino-protective reagent S. Tsunoda, T. Ishikawa, M. Watanabe, H. Kamada, Y. Yamamoto, Y. Tsutsumi, T. Hirano and T. Mayumi Large granular lymphocyte leukaemia is characterized by a clonal T-cell receptor rearrangement in both memory and effector CD8° lymphocyte populations J. J. Melenhorst, L. Sorbara, M. Kirby, N. E Hensel and A. J. Barrett Coincident myelodysplastic syndrome and T-cell large granular lymphocytic disease: clinical and pathophysiological features Y. Saunthararajah, J. J. Molldrem, M. Rivera, A. Williams, M. Stetler-Stevenson, L. Sorbara, N. S. Young and J. A. Barrett Short reports T-large granular lymphocyte leukaemia with natural killer cell-like cytotoxicity and expression of two different a- and B-T-cell receptor chains S. Boehrer, T. Hinz, D. K. Schui, S. Harder, K. U. Chow, B. Schneider, D. Hoelzer, P. S. Mitrou and E. Weidmann Polyclonal expansion of CD3 °/CD4°/CD56° large granular lymphocytes and autoimmunity associated with dysregulation of Fas/FasL apoptotic pathway A. Camagna, L. Cedrone, A. Caré, PR. Samoggia, M. Civita De Marco, P. Del Duca, C. De Martinis and U. Testa EVI] expression in acute myeloid leukaemia S. E. Langabeer, J. R. Rogers, G. Harrison, K. Wheatley, H. Walker, B. J. Bain, A. K. Burnett, A. H. Goldstone, D. C. Linch and D. Grimwade on behalf of the MRC Adult Leukaemia Working Party Glucose transport regulation by p210 Bcr—Abl in a chronic myeloid leukaemia model J. Bentley, I. Walker, E. McIntosh, A. D. Whetton, P. J. Owen-Lynch and S. A. Baldwin Cytotoxic T-lymphocyte antigen-4 microsatellite polymorphism is associated with multiple myeloma C. Zheng, D. Huang, L. Liu, M. Bjérkholm, G. Holm, Q. Yi and A. Sundblad TRANSPLANTATION Factors influencing haematological recovery after allogeneic haemopoietic stem cell transplants: graft-versus-host disease, donor type, cytomegalovirus infections and cell dose A. Dominietto, A. M. Raiola, M. T. van Lint, T. Lamparelli, EF Gualandi, G. Berisso, S. Bregante, E. Frassoni, L. Casarino, S. Verdiani and A. Bacigalupo Volume Contents Cytomegalovirus seropositivity adversely influences outcome after T-depleted unrelated donor transplant in patients with chronic myeloid leukaemia: the case for tailored graft-versus-host disease prophylaxis C. Craddock, R. M. Szydlo, F. Dazzi, E. Olavarria, K. Cwynarski, A. Yong, P. Brookes, J. de la Fuente, E. Kanfer, J. E Apperley and J. M. Goldman Cytomegalovirus infection and non-neutropenic fever after autologous stem cell transplantation: high rates of reactivation in patients with multiple myeloma and lymphoma A. B.-T. Fassas, J. Bolanos-Meade, L. N. Buddharaju, A. Rapoport, M. Cottler-Fox, T. Chen, J. C. Lovchik, A. Cross and G. Tricot Preceding chemotherapy, tumour load and age influence engraftment in multiple myeloma patients mobilized with granulocyte colony-stimulating factor alone K. R. Desikan, G. Tricot, N. C. Munshi, E. Anaissie, D. Spoon, A. Fassas, A. Toor, M. Zangari, A. Badros, C. Morris, D. H. Vesole, D. Siegel, S. Jagannath and B. Barlogie CORRESPONDENCE Microsatellite analysis in acute myeloid leukaemia evolving from myelodysplastic syndrome W. Olipitz, G. P. Tilz, C. Beham-Schmid, C. Eibinger, P. Kerzina and H. Sill Interleukin 6, tumour necrosis factor « and lymphotoxin polymorphisms in monoclonal gammopathy of uncertain significance and multiple myeloma A. M. Dring, E E. Davies, S. J. Rollinson, PR L. Roddam, A. C. Rawstron, J. A. Child, A. S. Jack and G. J. Morgan Reply to Dring et al C. Zheng and Q. Yi Prenatal diagnosis of severe factor VII deficiency using mutation detection and linkage analysis M. Giansily-Blaizot, P. Aguilar-Martinez, C. Mazurier, EF Cneude, J. Goudemand, J.-E Schved and B. de Martinville P-selectin and glycoprotein 53 expression in myeloproliferative disorders M. R. Cahill BOOK REVIEWS CORRIGENDUM ANNOUNCEMENT Volume 112, Issue 2, February 2001 IMAGES IN HAEMATOLOGY Leukaemic infiltration of an adenocarcinoma effusion W. Y. Au, T. W. Shek, R. D. Gascoyne and Y. L. Kwong Testicular relapse in acute promyelocytic leukaemia H. V. New, A. Dogan, K. Patterson and D. Grimwade REVIEWS T activation J. Ramasethu and N. L. C. Luban Perinatal management of newborns with haemophilia R. Kulkarni and J. Lusher Volume Contents ANNOTATION Practical application of minimal residual disease assessment in childhood acute lymphoblastic leukaemia N. Goulden, A. Oakhill and C. Steward HISTORICAL REVIEW Leukaemia — a brief historical review from ancient times to 1950 G. J. Piller HAEMATOLOGICAL MALIGNANCY Progressive reduction in treatment-related deaths in Medical Research Council childhood lymphoblastic leukaemia trials from 1980 to 1997 (UKALL VIII, X and XI) D. R. Hargrave, I. M. Hann, S. M. Richards, FE G. Hill, J. S. Lilleyman, S. Kinsey, C. C. Bailey, J. M. Chessells, C. Mitchell and O. B. Eden on behalf of the Medical Research Council Working Party for Childhood Leukaemia Mutations in ras proto-oncogenes are associated with lower mdr1 gene expression in adult acute myeloid leukaemia M. Schaich, M. Ritter, T. Illmer, P. Lisske, C. Thiede, U. Schdkel, B. Mohr, G. Ehninger and A. Neubauer Calcein assay for multidrug resistance reliably predicts therapy response and survival rate in acute myeloid leukaemia E. Kardszi, K. Jakab, L. Homolya, G. Szakacs, Z. Holld, B. Telek, A. Kiss, L. Rejté, S. Nahajevszky, B. Sarkadi and J. Kappelmayer Sensitization by 5-aza-2'-deoxycytidine of leukaemia cells with MLL abnormalities to induction of differentiation by all-trans retinoic acid and la,25-dihydroxyvitamin D; N. Niitsu, Y. Hayashi, K. Sugita and Y. Honma Engagement of the CrkL adaptor in interferon a signalling in BCR-ABL- expressing cells I. M. Grumbach, I. A. Mayer, S. Uddin, E Lekmine, B. Majchrzak, H. Yamauchi, S. Fujita, B. J. Druker, E. N. Fish and L. C. Platanias SIHONSCORE: a scoring system for external quality control of leukaemia/ lymphoma immunophenotyping measuring all analytical phases of laboratory performance J. C. Kluin-Nelemans, E. R. van Wering, C. E. van der Schoot, H. J. Adriaansen, M. B. van't Veer, J. J. M. van Dongen and J. W. Gratama on behaolf fth e Dutch Co-operative Study Group on Immunophenotyping of Haematological Malignancies (STHON) Early induction of apoptosis in B-chronic lymphocytic leukaemia cells by hydroxychloroquine: activation of caspase-3 and no protection by survival factors L. Lagneaux, A. Delforge, S. Carlier, M. Massy, M. Bernier and D. Bron Mortality and causes of death in patients with monoclonal gammopathy of undetermined significance H. Gregersen, J. S. Ibsen, L. Mellemkjer, J. E Dahlerup, J. H. Olsen and H. T. Sorensen Interferon a extends the survival of human myeloma cells through an upregulation of the Mcl-1 anti-apoptotic molecule D. Puthier, W. Thabard, M.-J. Rapp, M. Etrillard, J.-L. Harousseau, R. Bataille and M. Amiot viii Volume Contents bcl-2 and immunoglobulin gene rearrangement in patients with hepatitis C virus infection E. Zuckerman, T. Zuckerman, D. Sahar, S. Streichman, D. Attias, E. Sabo, D. Yeshurun and J. M. Rowe Short reports Long-lasting complete remission of hepatitis C virus (HCV) infection and HCV- associated immunocytoma with alpha-interferon treatment E. Patriarca, F. Silvestri, R. Fanin, E Zaja, A. Sperotto and M. Baccarani Epstein-Barr virus-positive aggressive lymphoma as a consequence of immunosuppression after multiple salvage treatments for follicular lymphoma E. Orlandi, M. Paulli, A. Viglio, G. Pagnucco, R. Riboni, E Baldanti and M. Lazzarino Fatal atypical T-cell proliferation associated with Epstein-Barr virus infection S. Hauptmann, N. Meru, C. Schewe, A. Jung, E Hiepe, G. R. Burmester, G. Niedobitek and F. Buttgereit Flow cytometry and the study of central nervous disease in patients with acute leukaemia D. Subira, S. Castarion, A. Roman, E. Aceituno, C. Jiménez-Garofano, A. Jiménez, R. Garcia and M. Berndacer Three cases of typical aplastic anaemia associated with a Philadelphia chromosome FE. Suzan, C. Terré, I. Garcia, J. N. Bastie, E. Baumelou, E. Gluckman and S. Castaigne Insertional events as well as translocations may arise during aberrant immunoglobulin switch recombination in a patient with multiple myeloma G. Pratt, J. A. L. Fenton, E E. Davies, A. C. Rawstron, S. J. Richards, J. E. Collins, R. G. Owen, A. S. Jack, G. M. Smith and G. J. Morgan TRANSPLANTATION Haemopoietic stem cell transplantation for advanced polycythaemia vera or essential thrombocythaemia M. Jurado, H. J. Deeg, T. Gooley, C. Anasetti, T. Chauncey, M. E. D. Flowers, D. Myerson, R. Storb and F. R. Appelbaum Long-term expansion and maintenance of cord blood haematopoietic stem cells using thrombopoietin, Flt3-ligand, interleukin (IL)-6 and IL-11 in a serum-free and stroma-free culture system L. Lazzari, S. Lucchi, PR. Rebulla, L. Porretti, G. Puglisi, L. Lecchi and G. Sirchia The superoxide dismutase content in erythrocytes predicts short-term toxicity of high-dose cyclophosphamide C. Dumontet, J. Drai, C. Thieblemont, O. Hequet, D. Espinouse, E. Bouafia, G. Salles and B. Coiffier Myeloma-reactive allospecific cytotoxic T lymphocytes lyse target cells via the granule exocytosis pathway M. Chiriva-Internati, J. Du, M. Cannon, B. Barlogie and Q. Yi Short reports Donor lymphocyte infusion enhances remission status in patients with persistent disease after allografting for multiple myeloma N. Kroger, W. Krtiger, H. Renges, T. Zabelina, N. Stute, R. Jung, G. Wittkowsky, R. Kuse and A. R. Zander Therapy-related myelodysplastic syndrome of recipient origin after allogeneic bone marrow transplantation for acute lymphoblastic leukaemia W. Y. Au, A. K. W. Lie, S. K. Ma, Y. H. Leung, L. L. P. Siu and Y. L. Kwong Fludarabine-based stem cell transplantation protocol for Fanconi’s anaemia in myelodysplastic transformation M. McCloy, A. Almeida, P. Daly, T. Vulliamy, I. A. G. Roberts and I. Dokal Volume Contents HAEMOPOIESIS Generation of human osteoclasts in stromal cell-free and stromal cell-rich cultures: differences in osteoclast CD11c/CD18 integrin expression C. S. Lader, J. Scopes, M. A. Horton and A. M. Flanagan Hepatocyte growth factor is secreted by osteoblasts and cooperatively permits the survival of haematopuietic progenitors R. S. Taichman, M. J. Reilly, R. S. Verma, K. Ehrenman and S. G. Emerson The granulocyte colony-stimulating factor receptor supports erythroid differentiation in the absence of the erythropoietin receptor or Stat5 G. A. Millot, E Svinarchuk, C. Lacout, W. Vainchenker and D. Dumenil Megakaryocytic differentiation is accompanied by a reduction in cell migratory potential A. Mathur, Y. Hong, J. E Martin and J. D. Erusalimsky Short report High levels of reticulated platelets and thrombopoietin characterize fetal thrombopoiesis P. Jilma-Stohlawetz, M. Homoncik, B. Jilma, C. C. Folman, A. E. G. Kr von dem Borne, G. Bernaschek, J. Deutinger, B. Ulm, W. Eppel and S. Panzer ERYTHROCYTES Familial pseudohyperkalaemia Chiswick: a novel congenital thermotropic variant of K and Na transport across the human red cell membrane P. G. Haines, C. Crawley, M. C. Chetty, H. Jarvis, S. E. Coles, J. Fisher, A. Nicolaou and G. W. Stewart Hereditary non-spherocytic haemolytic anaemia due to red blood cell glutathione synthetase deficiency in four unrelated patients from Spain: clinical and molecular studies J.-L. Vives Corrons, R. Alvarez, A. Pujades, R. Zarza, E. Oliva, G. Lasheras, M. Callis, A. Ribes, T. Gelbart and E. Beutler Detection of haemoglobin variants and inference of their functional properties by complete oxygen dissociation curve measurements K. Imai, P. Tientadakul, N. Opartkiattikul, P. Luenee, P- Winichagoon, J. Svasti and S. Fucharoen Short report Automated genotyping for accurate assignment of the (AT),N,(AT), motif within the B-globin locus control region-hypersensitive site 2 T. Tatu and S. L. Thein PLATELETS, HAEMOSTASIS AND THROMBOSIS Transient thrombopoietin peak after liver transplantation for end-stage liver disease M. Faeh, S. P. Hauser and U. E. Nydegger Interleukin 12 induces activation of fibrinolysis and coagulation in humans J. E. A. Portielje, W. H. J. Kruit, A. J. M. Eerenberg, M. Schuler, A. Sparreboom, C. H. J] Lamers, R. L. H. Bolhuis, G. Stoter, C. Huber and C. E. Hack Anti-thrombotic and haemorrhagic effects of active site-inhibited factor VIIa in rats E. Ghrib, P. Léger, M. Ezban, A. T. Kristensen, J. P- Cambus and B. Boneu Two novel and one recurrent missense mutation in the factor XIII A gene in two Dutch patients with factor XIII deficiency E. B. Gomez Garcia, S. R. Poort, J. Stibbe, A. Sturk, M. C. L. Schaap, M. Kappers and R. M. Bertina Volume Contents Monocytes, but not endothelial cells, downregulate the anticoagulant activity of activated protein C M. Colucci, A. M. Stramaglia, E. Mascolo, E. Napoleone, R. Lorenzet and N. Semeraro CORRESPONDENCE A case of refractory idiopathic pure red cell aplasia responsive to fludarabine treatment J.-H. Ahn, K.-H. Lee, J.-H. Lee, J.-S. Lee, C.-J. Park, H.-S. Chi and W.-K. Kim Treatment of leg ulcers with platelet-derived wound healing factor (PDWHEs) in a patient with beta thalassaemia intermedia D. Josifova, G. Gatt, A. Aquilina, V. Serafimov, A. Vella and A. E. Felice BOOK REVIEW Volume 112, Number 3, March-I 2001 IMAGES IN HAEMATOLOGY Amyloidosis I. Miyoshi and H. Taguchi Non-Hodgkin's lymphoma of the pelvic bone M. Sivakumaran REVIEWS Clinical governance C. Bunch Adhesion receptors on haematopoietic progenitor cells J. Y.-H. Chan and S. M. Watt HISTORICAL REVIEW Sir Leonard Parsons and the scientific basis of paediatric haematology R. E Stevens HAEMOSTASIS, THROMBOSIS AND PLATELETS Long-term outcome of individualized prophylactic treatment of children with severe haemophilia H. M. van den Berg, K. Fischer, E. P- Mauser-Bunschoten, E J. A. Beek, G. Roosendaal, J. G. van der Bom and H. K. Nieuwenhuis Novel mutations in the Factor VII gene of Taiwanese Factor VII-deficient patients M.-C. Shen, J.-S. Lin, S.-W. Lin, W.-S. Yang and B. Lin The association of vitamin K status with warfarin sensitivity at the onset of treatment M. Cushman, S. L. Booth, C. J. Possidente, K. W. Davidson, J. A. Sadowski and E. G. Bovill Von Willebrand factor collagen binding activity in the diagnosis of von Willebrand disease: an alternative to ristocetin co-factor activity? A. Casonato, E. Pontara, A. Bertomoro, EF. Sartorello, M. G. Cattini and A. Girolami Volume Contents Automated CD61 immunoplatelet analysis of thrombocytopenic samples D. Kunz, W. S. Kunz, C. S. Scott and A. M. Gressner Myristoylated alanine-rich C kinase substrate phosphorylation is involved in thrombin-induced serotonin release from platelets A. Elzagallaai, §. D. Rosé, N. C. Brandan and J.-M. Trifar6 Pathogenetic analysis of three cases with a bleeding disorder characterized by defective platelet aggregation induced by Ca** ionophores I. Fuse, W. Higuchi, Y. Uesugi and Y. Aizawa Platelet activation via the collagen receptor GPVI is not altered in platelets from chronic myeloid leukaemia patients despite the presence of the constitutively phosphorylated adapter protein CrkL D. Best, S. Pasquet, T. J. Littlewood, S. J. Brunskill, C. J. Pallister and S. PR. Watson Familial thrombocytosis as a recessive, possibly X-linked trait in an Arab family M. Stuhrmann, L. Bashawri, M. A. Ahmed, B. H. Al-Awamy, W. Kiihnau, J]. Schmidtke and E. A. El-Harith In vivo platelet activation in atherothrombotic stroke is not determined by polymorphisms of human platelet glycoprotein [Ila or Ib D. J. Meiklejohn, M. A. Vickers, E. R. Morrison, R. Dijkhuisen, I. Moore, S. J. Urbaniak and M. Greaves Short reports Platelet glycoprotein IIb polymorphism, traditional risk factors and non-fatal myocardial infarction in young women A. P. Reiner, S. M. Schwartz, PR. N. Kumar, E. R. Rosendaal, R. M. Pearce, K. M. Aramaki, B. M. Psaty and D. S. Siscovick Age as the major predictive factor of long-term response to splenectomy in immune thrombocytopenic purpura E. Fabris, T. Tassan, R. Ramon, G. Carraro, M. L. Randi, G. Luzzatto, P- Moschino and A. Girolami Injecting drug use is a risk factor for deep vein thrombosis in women in Glasgow M. D. McColl, R. C. Tait, I. A. Greer and I. D. Walker HAEMOPOIESIS The fleet feet of haematopoietic stem cells: rapid motility, interaction and proteopodia A. E. Frimberger, C. I. McAuliffe, K. A. Werme, R. A. Tuft, K. E. Fogarty, B. O. Benoit, M. S. Dooner and P. J. Quesenberry Short report The retinoblastoma family member, p107, is active in non-dividing monocyte- derived dendritic cells K. M. Ardeshna, E Ahmed, S. Devereux and N. S. B. Thomas LEUCOCYTES, INFECTION AND IMMUNODEFICIENCY Decreased prion protein expression in human peripheral blood leucocytes from patients with paroxysmal nocturnal haemoglobinuria J. Diirig, A. Giese, U. Schmiicker, H. A. Kretzschmar and U. Diihrsen Extracellular Tat activates c-fos promoter in low serum-starved CD4° T cells D. Gibellini, M. C. Re, C. Ponti, C. Celeghini, E. Melloni, M. La Placa and G. Zauli Rapid protein-based assays for the diagnosis of TB° severe combined immunodeficiency K. C. Gilmour, T. Cranston, S. Loughlin, J. Gwyther, T. Lester, T. Espanol, M. Hernandez, G. Savoldi, E. G. Davies, M. Abinun, C. Kinnon, A. Jones and H. B. Gaspar Volume Contents Short report Bone marrow involvement in Whipple’s disease: rarely reported, but really rare? R. Walter, S. P. Bachmann, A. Schaffner, R. Rtiegg and G. Schoedon HAEMATOLOGICAL MALIGNANCY In vitro drug resistance and prognostic impact of P16'\“*4/P15'**® deletions in childhood T-cell acute lymphoblastic leukaemia N. L. Ramakers-van Woerden, R. Pieters, R. M. Slater, A. H. Loonen, H. B. Beverloo, E. van Drunen, M. Heyman, T. Calero Moreno, M. G. Rots, E. R. van Wering, W. A. Kamps, G. E. Janka-Schaub and A. J. P- Veerman Single site polymorphisms and alternative splicing of the human CD13 gene — different splicing frequencies among patients with acute myeloid leukaemia and healthy individuals K. Dybker, J. S. Kristensen and FE. S. Pedersen Induction of the monocytic differentiation of myeloid leukaemia cells by cotylenin A, a plant growth regulator Y. Yamamoto-Yamaguchi, K. Yamada, Y. Ishii, K.-i. Asahi, S. Tomoyasu and Y. Honma In vivo suppression of Bcl-X;, expression facilitates chemotherapy-induced leukaemia cell death in a SCID/NOD-Hu model D. A. Fennell, M. V. Corbo, N. M. Dean, B. P. Monia and E E. Cotter Apoptosis in refractory anaemia with ringed sideroblasts is initiated at the stem cell level and associated with increased activation of caspases E. Hellstrém Lindberg, J. Schmidt-Mende, A. M. Forsblom, B. Christensson, B. Fadeel and B. Zhivotovsky Prognostic impact of bone marrow erythropoietic precursor cells and myelofibrosis at diagnosis of Ph'* chronic myelogenous leukaemia — a multicentre study on 495 patients H. M. Kvasnicka, J. Thiele, A. Schmitt-Graeff, V. Diehl, R. Zankovich, N. Niederle, L.-D. Leder and H. E. Schaefer Recognition of chronic myelogenous leukaemia cells by autologous T lymphocytes primed in vitro against the patient’s dendritic cells L. Miiller, C. Provenzani, C. Faul and G. Pawelec Expression of bcr—abl mRNA in individual chronic myelogenous leukaemia cells as determined by in situ amplification K. Pachmann, S. Zhao, T. Schenk, H. Kantarjian, A. K. El-Naggar, M. J. Siciliano, J.-Q. Guo, R. B. Arlinghaus and M. Andrecff Interleukin 4 content in chronic lymphocytic leukaemia (CLL) B cells and blood CD8° T cells from B-CLL patients: impact on clonal B-cell apoptosis N. E. Kay, L. Han, N. Bone and G. Williams MDM2 gene amplification and lack of p53 point mutations in Hodgkin and Reed-Sternberg cells: results from single-cell polymerase chain reaction and molecular cytogenetic studies M. Kiipper, S. Joos, E von Bonin, H. Daus, M. Pfreundschuh, P. Lichter and L. Trtimper Cyclin D1 and E2F-1 immunoreactivity in bone marrow biopsy specimens of multiple myeloma: relationship to proliferative activity, cytogenetic abnormalities and DNA ploidy C. S. Wilson, A. W. Butch, R. Lai, L. J. Medeiros, J. R. Sawyer, B. Barlogie, A. McCourty, K. Kelly and R. K. Brynes Short report Arsenic trioxide and ascorbic acid: synergy with potential implications for the treatment of acute myeloid leukaemia? T. Bachleitner-Hofmann, B. Gisslinger, E. Grumbeck and H. Gisslinger