British Journal of Haematology 1995: Vol 90 Table of Contents

11 Pages·1995·2.7 MB·English

BRITISH JOURNAL OF HAEMATOLOGY
VOL. 90 NO. 1 MAY 1995 Erythrocytes
Aueaiiinas 56 Enhanced Mg*2'+- ATPase actihvai ty :i n ghosts from
HS erythrocytes and in normal ghosts stripped
1 Low molecular weight heparin(s) of membrane skeletal proteins may reflect
Trevor W. Barrowcliffe enhanced aminophospholipid translocase
activity
Research Papers Willem P. Vermeulen, Jacob J. Briedé,
Gertrude Bunt, Jos A. F. Op den Kamp,
Haemopoiesis and growth factors
Rob J. Kraaijenhagen and Ben Roelofsen
8 Modulation of cell kinetics and cell cycle status by
treating CD34* chronic myeloid leukaemia cells Low plasma heparin cofactor II levels in
with p53 antisense phosphorothioate thalassaemia syndromes are corrected by
oligonucleotides chronic blood transfusion
Francesco Lanza, Sucai Bi, Sabrina Moretti, A. O'Driscoll, I. J. Mackie, J. B. Porter
Gianluigi Castoldi and John M. Goldman and S. J. Machin
Effects of interleukin-12 on natural killer cell
Haemoglobin Tunis-Bizerte:
cytotoxicity and the production of interferon-y
a new aq, globin 129 Leu — Pro unstable variant
and tumour necrosis factor-a in patients
with thalassaemic phenotype
with myelodysplastic syndromes
R. Darbellay, S. Mach-Pascual, K. Rose, J. Graf
K. Ogata, H. Tamura, N. Yokose, E. An, K. Dan,
and Ph. Beris
H. Hamaguchi, H. Sakamaki, Y. Onozawa,
S. C. Clark and T. Nomura
Scintigraphic evaluation of the haemopoietic bone
marrow using a °™T¢-anti-granulocyte antibody: Malignancy
a validation study with °?Fe 77 Leukaemic non-Hodgkin’s lymphomas
Francois Jamar, Catherine Field, Norbert Leners with hyperdiploid cells and t(11;14)(q13;q32):
and Augustin Ferrant a subtype of mantle cell lymphoma?
Administration of rHuGM-CSF activates Marie-Thérése Daniel, Isabelle Tigaud,
monocyte reactive oxygen species secretion Marie-Ange Flexor, Maria-Elena Nogueira,
and adhesion molecule expression Roland Berger and Philippe Jonveaux
in vivo in patients following high-dose
Assessment of clonal evolution at Ig/TCR loci in
chemotherapy
acute lymphoblastic leukaemia by single-strand
Marc A. Williams, Stephen M. Kelsey,
Peter W. Collins, Charles N. Gutteridge conformation polymorphism studies and
highly resolutive PCR derived methods:
and Adrian C. Newland
implication for a general strategy of
The effect of continuous G-CSF application minimal residual disease detection
in human cyclic neutropenia: André Baruchel, Jean-Michel Cayuela,
a model analysis Elisabeth MacIntyre, Roland Berger
Stephan Schmitz, Horst Franke, and Francois Sigaux
H. Erich Wichmann and Volker Diehl
Over-expression and amplification
of the CDC2 gene in leukaemia cells
Leucocytes
Yusuke Furukawa, Yasuhito Terui,
48 Clonal and non-clonal karyotypically Kumi Sakoe, Masatsugu Ohta, Seiichi Kitagawa,
abnormal cells in haemophagocytic Yasusada Miura and Masaki Saito
lymphohistiocytosis
Yasuhiko Kaneko, Nobuo Maseki, Clinical significance of serum thymidine kinase
Masaharu Sakurai, Masaru Ido, in adult T-cell leukaemia and
Yukiko Tsunematsu, Shuki Mizutani, acute myeloid leukaemia
Tatsuya Hattori, Hiroyuki Shimizu, Naoki Sadamori, Motoko Ichiba, Mariko Mine,
Haruhiko Eguchi, Toshiaki Oka, Satomi Hakariya, Toshihisa Hayashibara,
Munenori Miyake, Yasuo Horikoshi Takahiro Itoyama, Hideo Nakamura,
and Taizan Suchi Masao Tomonaga and Kuniaki Hayashi
Volume Contents
Prognostic implications of DNA aneuploidy Haemostasis and thrombosis
in 156 untreated multiple myeloma patients
R. Garcia-Sanz, A. Orfao, M. Gonzalez, M* J. Moro, 175 Evidence for a light chain restriction of glycoprotein
J. M. Hernandez, F. Ortega, D. Borrego, M. Carnero, Ib/IX and IIb/IIIa reactive antibodies in chronic
F. Casanova, R. Jiménez, J. A. Portero and idiopathic thrombocytopenic purpura (ITP)
J. F. San Miguel Dick Stockelberg, Ming Hou, Stefan Jacobsson,
Jack Kutti and Hans Wadenvik
Idiotypic oligonucleotide probes to detect
A low M, GTP-binding protein, Rap1,
myeloma cells by mRNA in situ hybridization
in human platelets: localization, translocation
Ross Brown, Xiao-Feng Luo, John Gibson,
and phosphorylation by
Alec Morley, Pam Sykes, Michael Brisco
cyclic AMP-dependent protein kinase
and Doug Joshua
Koh-ichi Nagata and Yoshinori Nozawa
Der(16)t(1;16)(q11;q11) in myelodysplastic Fibrin degradation product (FnDP) assays:
syndromes: a new non-random abnormality analysis of standardization issues and
characterized by cytogenic and fluorescence target antigens in plasma
in situ hybridization studies P. J. Gaffney, T. Edgell, L. J. Creighton-Kempsford,
Francine Mugneret, Nicole Dastugue, S. Wheeler and E. Tarelli
Bernadine Favre, Isabelle Sidaner, Bruno Salles,
A monoclonal antibody (B724) to
Francine Huguet-Rigal and Eric Solary
von Willebrand factor recognizing an epitope
within the Al disulphide loop (Cys509-—Cys695)
Prognostic relevance of serum thymidine kinase in
discriminates between type 2A and
primary myelodysplastic syndromes: relationship to
type 2B von Willebrand disease
development of acute myeloid leukaemia
O. Christophe, C. Rouault, B. Obert,
Pellegrino Musto, Carlo Bodenizza,
G. Piétu, D. Meyer and J. P. Girma
Antonietta Falcone, Giovanni D’Arena,
Potito Scalzulli, Gianni Perla, Sergio Modoni,
Luigi Parlatore, Maria Rosa Valvano and
Short Reports
Mario Carotenuto
204 Resistance to activated protein C activity
Clonal analysis of haemopoietic cells of an anti-G-glycoprotein I antibody
in essential thrombocythaemia in the presence of 3,-glycoprotein I
Nahed El Kassar, Gilles Hetet, Yan Li, Juzo Matsuda, Moritaka Gotoh, Kengo Gohchi,
Jean Briére and Bernard Grandchamp Kazuo Kawasugi, Miyo Tsukamoto and
Noriko Saitoh
Characterization of genomic BCR-ABL breakpoints
in chronic myeloid leukaemia by PCR Acquired hypochromic and microcytic sideroblastic
J. G. Zhang, J. M. Goldman and N. C. P. Cross anaemia responsive to pyridoxine with
low value of free erythrocyte protoporphyrin:
Hemizygous expression of the wild-type p53 allele a possible subgroup of idiopathic acquired
may confer a selective growth advantage before sideroblastic anaemia (IASA)
complete inactivation of the p53 gene in the Yasushi Takeda, Hiroyoshi Sawada,
progression of chronic myelogenous leukaemia Hirofumi Sawai, Tomoko Toi-Matsuda,
Hiroyuki Nakai, Shinichi Misawa, Masaro Tashima, Minoru Okuma,
Shigeo Horiike, Taira Maekawa, Kei Kashima Shigeya Watanabe, Seiichi Ohmori
and Kanji Ishizaki and Masao Kondo
Random X chromosome inactivation in a female
Evidence for a paracrine pathway of B-cell
with a variant of Wiskott-Aldrich syndrome
stimulation in hairy cell leukaemia
Susan J. Russell and Perry D. Nisen
Mathias Schmid, Hubert Schrezenmeier,
G. Staib and Franz Porzsolt Successful bone marrow transplantation
for idiopathic hypereosinophilic syndrome
Analysis of heat-shock protein expression Takuya Fukushima, Kazutaka Kuriyama,
in myeloid leukaemia cells by flow cytometry
Hajime Ito, Yasushi Miyazaki, Kosei Arimura,
Ian D. Chant, Peter E. Rose and Alan G. Morris
Tomoko Hata, Mamiko Saitoh and
Masao Tomonaga
Attenuated-dose idarubicin
in acute myeloid leukaemia of the elderly: Refractory cytopenia with t(1;7), + 8 abnormality
pharmacokinetic study and clinical results and dysplastic eosinophils showing
F. Leoni, S. Ciolli, G. Giuliani, A. Pascarella, intranuclear Charcot-Leyden crystals:
R. Caporale, F. Salti, L. Cervi and a fluorescence in situ hybridization study
P. Rossi Ferrini S. K. Ma, K. F. Wong, J. K. C. Chan and Y. L. Kwong
Volume Contents V
Expression of an erythropoietin-like gene Trisomy 11: an association with stem/progenitor
in the trout cell immunophenotype
A. Shiels and S. N. Wickramasinghe Marilyn L. Slovak, S. Thomas Traweek,
Cheryl L. Willman, David R. Head,
The fusion of TEL and ABL in human acute
Kenneth J. Kopecky, R. Ellen Magenis,
lymphoblastic leukaemia is a rare event
Frederick R. Appelbaum and Stephen J. Forman
Johannes W. G. Janssen, Susan A. Ridge,
Panos Papadopoulos, Finbarr Cotter,
All-trans retinoic acid shows multiple effects
Wolf-Dieter Ludwig, Christa Fonatsch,
on the survival, proliferation and differentiation
Harald Rieder, Wolfram Ostertag, Claus R. Bartram
of human fetal CD34* haemopoietic progenitor
and Leanne M. Wiedemann
cells
Detection of the BCR-ABL gene by reverse Giorgio Zauli, Giuseppe Visani, Marco Vitale,
transcription/polymerase chain reaction and Davide Gibellini, Lucia Bertolaso and
fluorescence in situ hybridization in a patient Silvano Capitani
with Philadelphia chromosome negative
acute lymphoblastic leukaemia A phase I/II trial of recombinant human
F. van Rhee, A. Kasprzyk, A. Jamil, H. Dickinson, interleukin-6 in patients with aplastic anaemia
F. Lin, N. C. P. Cross, M. C. Galvin, J. M. Goldman Hubert Schrezenmeier, Judith C. W. Marsh,
and L. M. Secker-Walker Patricia Stromeyer, Hilke Miiller,
Hermann Heimpel, Edward C. Gordon-Smith
Haemoglobin Dhofar is linked to the
and Aruna Raghavachar
codon 29 CT (IVS-1 nt —3) splice mutation
which causes 3° thalassaemia Flow cytometric analysis of homologous restriction
D. Williamson, K. P. Brown, J. V. Langdown factor 20KD (HRF20) expression on progeny cells
and T. P. Baglin during differentiation from haemopoietic
Correspondence progenitors in paroxysmal nocturnal
haemoglobinuria
232 G-CSF and neutrophil chemotaxis Tomoko Nishimura, Akihisa Kanamaru,
Ivana Turilli, Desirée Bowers, Ingrid Aronson, Eizo Kakishita and Kiyoyasu Nagai
Lucille Woods, Peter Jacobs, Karsten Spiekermann
and Joachim Roesler
Leucocytes
234 Book Reviews
300 Expansion of CD8*CD57* Tc ells after allogeneic
BMT is related with a low incidence of relapse
VOL. 90 NO. 2 JUNE 1995 and with cytomegalovirus infection
H. Dolstra, F. Preijers,
Annotations E. Van de Wiel-van Kemenade, A. Schattenberg,
J. Galama and T. de Witte
235 AIDS-related lymphomas:
from pathogenesis to pathology
Molecular analysis of the chromosomal breakpoint
Gianluca Gaidano and Antonino Carbone and fusion transcripts in the acute lymphoblastic
244 A reliable marker of endothelial cell dysfunction: SEM cell line with chromosomal translocation
does it exist? t(4;11)
Andrew D. Blann and David A. Taberner R. Marschalek, J. Greil, K. Lochner, I. Nilson,
G. Siegler, I. Zweckbronner, J. D. Beck and
Research Papers G. H. Fey
Haemopoiesis and growth factors
249 Characterization of insulin-like growth factor Platelets and megakaryocytes
binding proteins (IGFBP) and regulation of IGFBP-4
321 Antenatal screening for fetal alloimmune
in bone marrow stromal cells
thrombocytopenia: the results of a pilot study
Pascale Grellier, Douglas Yee, Myrna Gonzalez
H. A. Doughty, M. F. Murphy, P. Metcalfe
and Sherry L. Abboud
and A. H. Waters
Transcriptional and post-transcriptional regulation
of granulocyte-macrophage colony-stimulating The determination of spontaneous megakaryocyte
factor production in human growth factor colony formation is an unequivocal test for
dependent M-07e cells discrimination between essential
Maria Felice Brizzi, Pier Riccardo Rossi, thrombocythaemia and reactive thrombocytosis
Arturo Rosso, Gian Carlo Avanzi and Zoran Rolovic, Nadezda Basara, Mirjana Gotic,
Luigi Pegoraro Dijana Sefer and Andrija Bogdanovic
vi Volume Contents
332 Bacterial infection-associated improvement of Circumvention of P-glycoprotein-mediated
platelet counts in two patients with chronic and drug resistance in human leukaemic cells by
unresponsive idiopathic thrombocytopenic purpura non-immunosuppressive cyclosporin D analogue,
with normal platelet survival studies SDZ PSC 833
José O. Bordin, James W. Smith, Xu-Rong Jiang, Stephen M. Kelsey, Yu-Ling Wu
Catherine P. M. Hayward, Theodore E. Warkentin, and Adrian C. Newland
Parveen Wasi and John G. Kelton
Comparative study of peripheral blood progenitor
cell collection in patients with multiple myeloma
Direct evidence for dissociated megakaryocytic
after single-dose cyclophosphamide combined with
chimaerism in a Wiskott-Aldrich patient
rhGM-CSF or rhG-CSF
successfully allografted
Hilde Demuynck, Michel Delforge, Gregor Verhoef,
Véronique Brunel, Marie Joélle Mozziconacci,
Pierre Zachée, Peter Vandenberghe and
Danielle Sainty, Catherine Faucher,
Marc Boogaerts
Christine Arnoulet, Jacqueline Simonetti,
Dominique Maraninchi, Didier Blaise and GST- and P-170 co-expression
Marina Lafage-Pochitaloff in multiple myeloma
Mario Petrini, Daniela Di Simone, Adriana Favati,
Letizia Mattii, Paola Valenti and Bruno Grassi
Erythrocytes
T-cell-rich B-cell lymphoma and
341 Sustained increase in haemoglobin and RBC
lymphocyte-prodominant Hodgkin's disease:
following long-term administration of recombinant
two closely related entities?
human erythropoietin to patients with
U. Schmidt, K. A. Metz and L.-D. Leder
homozygous beta-thalassaemia
E. A. Rachmilewitz, M. Aker, D. Perry and G. Dover Biallelic DNA rearrangements and deletions within
the BCL-6 gene in non-Hodgkin’s lymphoma
Yuichi Nakamura, Tohru Miki,
Malignancy Norihiko Kawamata, Shinsaku Hirosawa,
Kenji Saito, Hideo Enokihara, Shinpei Furusawa
346 Philadelphia chromosome-negative chronic
and Hideo Shishido
myeloid leukaemia: a report of 14 new cases
R. Costello, M. Lafage, Y. Toiron, V. Brunel, Atypical chronic lymphocytic leukaemia
D. Sainty, C. Arnoulet, M.-J. Mozziconacci, with t(11;14)(q13;q32): karyotype evolution
R. Bouabdallah, J.-A. Gastaut, D. Maraninchi
and prolymphocytic transformation
and J. Gabert Antonio Cuneo, Massimo Balboni, Nadia Piva,
Gian Matteo Rigolin, Maria Grazia Roberti,
Rearrangement of the immunoglobulin heavy Cristina Mejak, Sabrina Moretti, Renato Bigoni,
chain gene in juvenile chronic myeloid leukaemia Rosa Balsamo, Pierluigi Cavazzini and
Ziva Mark, Amos Toren, Ninette Amariglio, Gianluigi Castoldi
Ami Vonsover, Gideon Rechavi and
Frida Brok-Simoni Establishment and characterization of IRTA17
and IRTA21, two novel acute non-lymphocytic
Abnormal TCR VQ repertoire leukaemia cell lines with t(16;21) translocation
in patients with chronic myeloid leukaemia Motofumi Hiyoshi, Takahisa Yamane,
Manabu Hirai, Shinichi Tagawa, Hideki Hattori,
S. Coleman, P. Perera, J. Fisher, T. Hoy,
A. K. Burnett and S. H. Lim Yoshitake Nakao, Yoshinori Yasui,
Key-Ryang Koh, Masayuki Hino and
Noriyuki Tatsumi
Polyclonal haemopoiesis associated with long-term
persistence of the AML1-ETO transcript in patients
with FAB M2 acute myeloid leukaemia in
continuous clinical remission Haemostasis and thrombosis
Angelo Guerrasio, Claudia Rosso,
425 Characterization of protein disulphide isomerase
Giovanni Martinelli, Francesco Lo Coco,
released from activated platelets
Maria Pampinella, Alessandra Santoro,
Kui Chen, Thomas C. Detwiler and
Carlo Lanza, Bernardino Allione, Luigi Resegotti
David W. Essex
and Giuseppe Saglio
An ELISA for factor X activation peptide:
Low incidence of MDR1 expression application to the investigation of thrombogenesis
in acute promyelocytic leukaemia in cardiopulmonary bypass
Doris Drach, Shourong Zhao, Johannes Drach Helen Philippou, Antonella Adami,
and Michael Andreeff Michael D. Boisclair and David A. Lane
Volume Contents vii
438 The effect of endogenous oestradiol levels on protein 479 Coronary artery bypass surgery in patients
S concentration during a menstrual cycle and after with inherited antithrombin deficiency
GnRH analogues and gonadotropin therapy P. Clark, Isobel D. Walker and R. F. Neilson
L. Falkon, M. Gari, J. L. Garcia Mora, J. Calaf,
J. Rodriguez Espinosa, A. Oliver and J. Fontcuberta A promoter mutation, C — T at position —92,
leading to silent G-thalassaemia
Screening for mutations in haemophilia A patients Maria Cristina Rosatelli, Valeria Faa,
by multiplex PCR-SSCP, Southern blotting and Alessandra Meloni, Flavia Fiorenza,
RNA analysis: the detection of a genetic Renzo Galanello, Daniela Gasperini,
abnormality in the factor VIII gene Giovanni Amendola and Antonio Cao
in 30 out of 35 patients
W. C. Pieneman, P. P. Deutz-Terlouw, C-myc amplification, double minutes and
P. H. Reitsma and E. Briét homogenous staining regions in a case of AML
C. D. Fegan, D. White and M. Sweeney
Short Reports
450 Severe hypophosphataemia during stem cell Correspondence
harvesting in chronic myeloid leukaemia
489 Therapy-related acute myeoblastic leukaemia
Richard E. Clark and Edwin S. Lee
(M1) with a 9;11 translocation
Macrophage colony-stimulating factor-producing Janet Hallett, Ingrid Aronson, Peter Jacobs,
malignant histiocytosis Hideo Nakamura, Naoki Sadamori and
Shuji Ozaki, Takaya Matsushita, Makatoto Ide, Masao Tomonaga
Keiji Ozaki, Toshiaki Sano, Masaaki Kosaka
and Shiro Saito 491 Orbituary: Professor L. G. Lajtha, 1920-95
CMV viraemia demonstrated in the serum 491 Book Review
of a patient with cytomegalovirus pneumonia
492 Announcements
Naoki Watanabe, Mitsuaki Takeda, Seishi Ishigaki,
Naoki Tsuji, Sumio Sakamaki, Junji Kato, 492 Corrigenda
Kyuhei Kohda, Yoshihiro Mori and Yoshiro Niitsu
Clinicopathological correlates of CD56 expression VOL. 90 NO. 3 JULY 1995
in multiple myeloma: a unique entity?
Paul Mathew, Gregory J. Ahmann,
Annotations
Thomas E. Witzig, Patrick C. Roche, Robert A. Kyle
and Philip R. Greipp 493 Not another lymphoma classification!
Karyotypic evolution in a granulocytic sarcoma D. Y. Mason and K. C. Gatter
developing in a myeloproliferative disorder
498 Why do so many haemophilia A patients develop
with a novel (3;4) translocation
an inhibitor?
H. Myint, J. Chacko, S. Mould, F. Ross
Leon W. Hoyer
and D. G. Oscier
Persistence of multilineage host haemopoiesis
Research Papers
following allogeneic bone marrow transplantation
Cathy M. Price, Susan M. Colman and Haemopoiesis and growth factors
Edward J. Kanfer
502 Chimaeric cultures of human marrow stroma and
Pearson’s marrow/pancreas syndrome: murine leukaemia cells: evidence for abnormalities
haematological features associated with deletion in the haemopoietic microenvironment in myeloid
and duplication of mitochondrial DNA malignancies and other infiltrating marrow
O. P. Smith, I. M. Hann, C. E. Woodward disorders
and M. Brockington Ulrich Diihrsen, Gabriele Knieling, Wolf Beecken,
Dapsone for refractory idiopathic Stefan Neumann and Dieter Kurt Hossfeld
thrombocytopenic purpura
Propagation of large numbers of cells of a human
Fernando Hernandez, Mariano Linares,
mixed-lineage T-lymphoid/myeloid
Pedro Colomina, Emilio Pastor, Antonio Cerver6o,
Ingo G. H. Schmidt-Wolf, Beate Grimm, Petja
Amalia Pérez and Matilde Perella
Lefterova, Valerie Johnston, Christian Scheffold,
Deletion of chromosome 13 (band q14) Dieter Huhn and Stefan Serke
but not trisomy 12 is a clonal event
in B-chronic lymphocytic leukaemia (CLL) IL-3 is produced by normal stroma in
Shireen A. B. Jabbar, Kanagasabai Ganeshaguru, long-term bone marrow cultures
Ranmohan G. Wickremasinghe, F. M. Gibson, J. Scopes, S. Daly, S. Rizzo,
A. Victor Hoffbrand and Letizia Foroni S. E. Ball and E. C. Gordon-Smith
viii Volume Contents
Leucocytes Diverse expression of cytosolic phospholipase A,,
526 Chronic active Epstein-Barr virus disease in a case S-lipoxygenase end: prostaginndia: Hi
synthase 2 in acute pre-B-lymphocytic
of persistent polyclonal B-cell lymphocytosis
leukaemia cells
Manfred Mitterer, Norbert Pescosta, Falko Fend,
Stina Feltenmark, Gudmundur Runarsson,
Clara Larcher, Nadja Prang, Fritz Schwarzmann,
Pontus Larsson, Per-Johan Jakobsson,
Paolo Coser and Hartwig P. Huemer
Magnus Bjérkholm and Hans-Erik Claesson
Role of Epstein-Barr virus and soluble CD21
in persistent polyclonal B-cell lymphocytosis Allogeneic marrow grafts from donors
Clara Larcher, Falko Fend, Manfred Mitterer, with congenital chromosomal abnormalities
Nadja Prang, Fritz Schwarzmann and in marrow cells
Hartwig P. Huemer Jordi Barquinero, Robert Witherspoon,
Jean Sanders, Mary M. Horowitz, Aldo Montuoro,
Influence of white blood cells on the fibrinolytic Donna F. Patton, Andrea Bacigalupo,
response to sepsis: studies of septic patients with M. M. Abecasis, Thomas Miale, Ciril Rozman,
or without severe leucopenia Eileen Bryant and Rainer Storb
Montaser A. Haj, Ian J. Neilly, Linda A. Robbie,
Gillian D. Adey and Bruce Bennett The myelodysplastic syndromes:
an analysis of prognostic factors in 226 cases
Clonal B-cell expansions in peripheral blood
from a single institution
of HCV-infected patients
I. Cunningham, S. J. MacCallum, M. D. Nicholls,
F. Franzin, D. G. Efremov, G. Pozzato, P. Tulissi,
F. Batista and O. R. Burrone K. Byth, J. W. Hewson, B. Arnold, P. I. Motum,
S. P. Mulligan and G. G. Crane
Erythrocytes Expression of erythroid-specific genes
in acute megakaryoblastic leukaemia
553 Ethnic distribution of allele a’, a low-expression
and transient myeloproliferative disorder
allele of red-cell spectrin a-gene
in Down’s syndrome
J. Maréchal, R. Wilmotte, A. Kanzaki, D. Dhermy,
Etsuro Ito, Mikio Kasai, Yasuhide Hayashi,
M. Garbarz, C. Galand, T. K. Tang, Y. Yawata and
Tsutomu Toki, Koji Arai, Shinkichi Yokoyama,
J. Delaunay
Koji Kato, Naoki Tachibana, Masayuki Yamamoto
Hydroxyurea therapy in G-thalassaemia and Masaru Yokoyama
intermedia: improvement in haematological
parameters due to enhanced G-globin synthesis Persistence of RARa-PML fusion mRNA detected
Yi-Tao Zeng, Shu-Zhen Huang, Zhao-Rui Ren, by reverse transcriptase polymerase chain reaction
Zhi-Hong Lu, Fan-Yi Zeng, Alan N. Schechter in patients in long-term remission of acute
and Griffin P. Rodgers promyelocytic leukaemia
Khalid Tobal, Melanie J. Saunders, Mark R. Grey
Detection of 3-thalassaemia mutations and John A. Liu Yin
using DNA heteroduplex generator molecules
David A. Savage, Nigel A. P. Wood, Cytogenetic study in multiple myeloma
Jeffrey L. Bidwell, Alison Fitches, John M. Old at diagnosis: comparison of two techniques
and Kam M. Hui Nicole Veronique Smadja, Christophe Louvet,
Francoise Isnard, Jean-Louis Dutel, Marie-josé
Grange, Charles Varette and Marcel Krulik
Malignancy
572 Differential sensitivity of CD30* neoplastic cells CD3-induced T-cell activation
to gelonin delivered by anti-CD30/anti-gelonin in the bone marrow of myeloma patients:
bispecific antibodies major role of CD4* cells
Sabrina Sforzini, Andrea Bolognesi, Alberto Bianchi, Laura Montacchini, Paola Barral,
Raffaella Meazza, Sabrina Marciano, Paolo Borrione, Carmela Attisano, Enrica Orsini,
Patrizia Casalini, Horst Diirkop, Pier Luigi Tazzari, Mario Boccadoro, Alessandro Pileri and
Harald Stein, Fiorenzo Stirpe and Silvano Ferrini Massimo Massaia
The detection of clonal proliferation in granular
Haemostasis, thrombosis and platelets
lymphocyte-proliferative disorders of natural killer
cell lineage 633 Redistribution of GPIb/IX and GPIIb/IIa
Shigetaka Shimodaira, Fumihiro Ishida, during spreading of discoid platelets
Hikaru Kobayashi, Bilkis Mahbub, Keisei Kawa-Ha James G. White, Marlys D. Krumwiede,
and Kiyoshi Kitano Debra K. Johnson and Gines Escolar
Volume Contents ix
Confirmation that GP Ib-IX complexes have a The gp 130 family cytokines IL-6, LIF and OSM but
reduced surface distribution on platelets activated not IL-11 can reverse the anti-proliferative effect of
by thrombin and TRAP-14-mer peptide dexamethasone on human myeloma cells
Alan Nurden, Eric Cazes, Claude Bihour, Nadine Juge-Morineau, Sylvie Francois,
Michel Humbert, Robert Combrié, Denis Puthier, Anne Godard, Regis Bataille
Annie Paponneau, Joélle Winckler and Martine Amiot
and Paquita Nurden
Growth inhibition of leukaemic cells carrying the
Maternal alloimmunization against fetal platelet t(3;21) by the AML1/EVI-1-specific antisense
antigens: a prospective study oligonucleotide
Simon Panzer, Leo Auerbach, Eva Cechova, Kinuko Mitani, Seishi Ogawa, Tomoyuki Tanaka,
Gottfried Fischer, Andrea Holensteiner, Mineo Kurokawa, Yoshio Yazaki and Hisamaru
Eva-Maria Kittl, Wolfgang Richard Mayr, Hirai
Michael Putz, Peter Wagenbichler and
Low-intensity oral anticoagulation in sickle-cell
Sabine Walchshofer
disease reverses the prethrombotic state: promises
Absence of incorporation of plasma for treatment?
von Willebrand factor into porcine platelet Hugo J. Wolters, Hugo ten Cate, Lambertus L. M.
a-granules Thomas, Desiderius P. M. Brandjes, Abraham van
Jacqueline Roussi, Ludovic Drouet, Jeff Sigman, der Ende, Yvonne van der Heiden and Lodewijk W.
Marcel Vaiman, Georges Pignaud, Michel Bonneau, Statius van Eps
Jean-Marc Masse and Elisabeth Martin Cramer
Predicting the severity of haemolytic disease of the
Measurement of factor Xa-antithrombin III in plasma: newborn: an assessment of the clinical usefulness of
relationship to prothrombin activation in vivo the chemiluminescence test
Isabelle Gouin-Thibault, Lori Dewar, A. L. Noble, G. D. Poole, N. Anderson, G. G. Lucas
Myron Kulczycky, Marion Sternbach and A. G. Hadley
and Frederick A. Ofosu
Excessive bone resorption in human
plasmacytomas: direct induction by tumour cells
in vivo
Ferritin excretion and iron balance in humans Régis Bataille, Daniel Chappard and Michel Basle
Barry S. Skikne, Paul Whittaker, Allen Cooke Development of resistance to activated protein C
and James D. Cook during pregnancy
A. M. Cumming, R. C. Tait, S. Fildes, A. Yoong,
Rapid Papers
S. Keeney and C. R. M. Hay
688 A point mutation (Arg271—Cys) of a homozygote
Flow cytometric analysis of decay-accelerating
for dysfunctional prothrombin, prothrombin
factor (CD55) on neutrophils from aplastic
Obihiro, which has a region of high sequence
anaemia patients
variability
Rafeal Forés, Maria Alcocer, Jose L. Diez-Martin
Toshiyuki Miyata, Yan-Zhen Zheng, Atsushi Kato
and Manuel N. Fernandez
and Hisao Kato
Monoclonal gammopathy of undetermined Correspondence
significance: chromosome changes are a common
731 Serum IL-6 concentrations in lymphomas
finding within bone marrow plasma cells
Y. Denizot, P. Fixe, E. Liozon, C. Brigaudeau,
Marc Zandecki, Valérie Obein, Franck Bernardi,
V. Praloran, Michel Guiguet, Laurence Duvillard
Valérie Soenen, Martial Flactif, Jean Luc Lai,
and Eric Solary
Michel Francois and Thierry Facon
Emergence of karyotypically unrelated clones in
Short Reports remission of de novo acute myeloid leukaemia
Simon N. Jowitt and John A. Liu Yin
697 Trisomy 8 in acute promyelocytic leukaemia:
an interphase study by fluorescence in situ 734 Book Reviews
hybridization
Y. L. Kwong, K. F. Wong and T. K. Chan
VOL. 90 NO. 4 AUGUST 1995
Combined immunophenotyping and in situ
hybridization (FICTION): a rapid method to study Annotations
cell lineage involvement in myelodysplastic
735 Modifiers of multidrug resistance
syndromes
Peter R. Twentyman
Valérie Soenen, Pierre Fenaux, Martial Flactif,
Pascale Lepelley, Jean Luc Lai, Alain Cosson 738 In search of the haemopoietic stem cell
and Claude Preudhomme M. A. Scott and M. Y. Gordon
x Volume Contents
Research Papers 817 Hereditary xerocytosis: a report of six unrelated
Spanish families with leaky red cell syndrome
Haemopoiesis and growth factors
and increased heat stability of the erythrocyte
744 Probability of progenitor renewal (PPR) and membrane
production of clonogenic progeny (CFU-GM) by L. LI. Vives Corrons, I. Besson, M. Aymerich,
primitive adherent progenitor cells in adult human S. Ayala, N. Alloisio, J. Delaunay, I. Gonzalez
bone marrow and umbilical cord blood and E. Manrubia
M. Y. Gordon, J. L. Lewis, M. A. Scott,
Mutations in the erythrocyte chemokine receptor
I. A. G. Roberts and J. M. Goldman
(Duffy) gene: the molecular basis of the Fy*/Fy°
Impaired cytokine production by bone marrow antigens and identification of a deletion in the Duffy
stromal cells of immunodeficient mice gene of an apparently healthy individual with the
Anne W. Hamburger Fy(a—b—) phenotype
G. Mallinson, K. S. Soo, T. J. Schall, M. Pisacka
Immunohistochemical characterization
and D. J. Anstee
of intact stromal layers in long-term cultures
of human bone marrow
Malignancy
B. S. Wilkins and D. B. Jones
830 Heterogeneity in cell proliferation and expression
The effect of haemopoietic growth factors
of p53 and bcl-2 during the indolent phase
on the cell cycle of AML progenitors
of germinal centre cell lymphoma:
and their sensitivity to cytosine arabinoside in vitro
an explanation for clinical variability
M. A. Smith, C. R. J. Singer, C. J. Pallister and
S. Barrans, J. Randerson, P. Evans, D. Blythe,
J. G. Smith
C. Shiach, J. A. Child, G. Morgan and A. S. Jack
Flow cytometric analysis of intracellular CD68
molecule expression in normal and malignant Autotumour reactive T-cell clones
haemopoiesis among tumour-infiltrating T lymphocytes
Herbert Strobl, Clemens Scheinecker, Bettina in B-cell non-Hodgkin’s lymphomas
Csmarits, Otto Majdic and Walter Knapp Isabelle Shi, Thierry Bonnefoix,
Francoise Heuzé-Le Vacon, Marie-Christine Jacob,
In vivo effects of interleukin-11 and stem cell factor
Dominique Leroux, Rémy Gressin,
in combination with erythropoietin
Marie-France Sotto, Philippe Chaffanjon,
in the regulation of erythropoiesis
Jean-Claude Bensa and Jean-Jacques Sotto
Gerald de Haan, Bert Dontje, Christoph Engel,
Markus Loeffler and Willem Nijhof Evaluation of cerebrospinal fluid EBV-DNA and
IL-10 as markers for in vivo diagnosis of AIDS-
Leucocytes related primary central nervous system lymphoma
Andrea De Luca, Andrea Antinori, Antonella
791 Platelet-induced neutrophil activation: platelet-
Cingolani, Luigi Maria Larocca Angela Linzalone,
expressed fibrinogen induces the oxidative burst in
Adriana Ammassari, Massimo Scerrati,
neutrophils by an interaction with CD11C/CD18
Romeo Roselli, Enrica Tamburini and Luigi Ortona
Andreas Ruf and Heinrich Patscheke
A specific chromosome abnormality of
Idiopathic macrocytic anaemia in the aged:
t(4;12)(q11-12;p13) in CD7* acute leukaemia
molecular and cytogenetic findings
Hironori Harada, Hiroya Asou, Taiichi Kyo, Hideki
Pekka Anttila, Jarkko Ihalainen, Armi Salo,
Asaoku, Koji Iwato, Hiroo Dohy, Kenji Oda, Yuka
Mervi Heiskanen, Eeva Juvonen and Aarno Palotie
Harada, Kenkichi Kita and Nanao Kamada
BCL-2 expression by leukaemic blasts in a SCID
Erythrocytes
mouse model of biphenotypic leukaemia associated
804 Transplanted sickle-cell disease patients with with the t(4;11)(q21;23) translocation
autologous bone marrow recovery after graft C. F. E. Pocock, M. Malone, M. Booth, M. Evans,
failure develop increased levels of fetal haemoglobin G. Morgan, J. Greil and F. E. Cotter
which corrects disease severity
A. Ferster, F. Corazza, F. Vertongen, W. Bujan, Minimally differentiated erythroleukaemia
C. Devalck, P. Fondu, P. Cochaux, M. Lambermont, (AML M6 ‘variant’): a rare subset of AML
Z. Khaladji and E. Sariban distinct from AML M6
Richard Garand, Eliane Duchayne, Dominique
Reverse dot-blot detection of Thai f-thalassaemia Blanchard, Nelly Robillard, Emilienne Kuhlein,
mutations Odile Fenneteau, Florence Salomon-Nguyen, Marie
Pranee Sutcharitchan, Randall Saiki, Suthat José Grange, Philippe Rousselot, Cécile Demur,
Fucharoen, Pranee Winichagoon, Henry Erlich Pascaline Talmant, Isabelle Radford and Georges
and Stephen H. Embury Flandrin
Volume Contents xi
Gene transfer A linkage between hereditary hyperferritinaemia
not related to iron overload and autosomal
876 Transduction of MDR1 into human and mouse
dominant congenital cataract
haemopoietic progenitor cells: use of rhodamine
Domenico Girelli, Oliviero Olivieri,
(Rh123) to determine transduction frequency
Lucia De Franceschi, Roberto Corrocher,
and its in vivo selection
Gaetano Bergamaschi and Mario Cazzola
Susanna Hegewisch-Becker, Elie G. Hanania,
Siquing Fu, Martin Korbling, Albert B. Deisseroth
The effect of interleukin-12 in ex-vivo expansion
and Michael Andreeff
of human haemopoietic progenitors
Francesco Bertolini, Davide Soligo, Lorenza Lazzari,
Haemostasis and thrombosis Chiara Corsini, Federica Servida and
Girolamo Sirchia
884 A chromogenic assay for activated protein C
resistance Detection of c-fms protooncogene in early mouse
K. Varadi, B. Mortiz, H. Lang, K. Bauer, E. Preston, embryos by whole mount in situ hybridization
I. Peake, G. E. Rivard, B. Keil and H. P. Schwarz indicates roles for macrophages
Major basic protein binding to thrombomodulin in tissue remodelling
potentially contributes to the thrombosis David A. Hume, Susan J. Monkley
in patients with eosinophilia and Brandon J. Wainright
Harumi Yamamoto Mukai, Haruhiko Ninomiya,
Hepatosplenic gamma-delta T-cell malignant
Koji Ohtani, Toshiro Nagasawa and Tsukasa Abe
lymphoma: report of the first case in childhood,
Binding of cardiolipin to polystyrene beads: including molecular minimal residual disease
evidence for a lamellar phase orientation follow-up
Michael W. Stewart, Philip A. Gordon, F. Garcia-Sanchez, J. Menarguez, E. Cristobal,
Wai S. Etches, Halyna Marusyk, Sibrand Poppema, A. Cantalejo, J. Gil, P. Algara and J. L. Vicaric
Colin Bigam and Brian Sykes
Mobilization of CD34-positive tumour cells
Severe haemophilia A in a female
in a patient with testicular mixed germ cell
resulting from two de novo factor VIII mutations
Sharon Windsor, Ann Lyng, Sherryl A. M. Taylor, tumour
Walter Verbeek, Andreas Pies, Andreas Humpe,
Bruce M. Ewenstein, Ellis J. Neufeld and
David Lillicrap Doris Grove, Carmen Troff, Ekkehard Kunze,
Wolfgang Hiddemann
Molecular bases of CRM* factor X deficiency:
and Bernard Wérmann
a frequent mutation (Ser334Pro) in the catalytic
domain and a substitution (Glu102Lys) Acute myeloblastic leukaemia without
in the second EGF-like domain Philadelphia chromosome developing after
G. Marchetti, G. Castaman, M. Pinotti, B. Langhi, interferon therapy for chronic myelocytic
M. G. di Iasio, M. Ruggieri, F. Rodeghiero and leukaemia with Philadelphia chromosome
F. Bernardi Eiichi Ohtsuka, Hiroshi Kikuchi, Yusei Abe,
Identification of two novel mutations Kyoko Moriyama, Eiji Ohno, Kiyoshi Hirota,
in non-Jewish factor XI deficiency Kazuhito Tezono and Masaru Nasu
Yasufumi Imanaka, Kalpana Lal, Takuya
Validation of a model to predict survival
Nishimura, Paula H. B. Bolton-Maggs,
in elderly patients with acute myeloid leukaemia
Edward G. D. Tuddenham and John H. McVey
Peter R. E. Johnson, W. David J. Ryder and
Rapid Paper John A. Liu Yin
921 Differential effects of recombinant human Theophylline, a new inducer of apoptis in B-CLL:
interleukin-13 on the in vitro growth role of cyclic nucleotides
of human haemopoietic progenitor cells Frank Mentz, Helene Merle-Beral, Fateh Ouaaz
Xiaodong Xi, Nicole Schlegel, Jacques P. Caen, and Jacques-Louis Binet
Adrian Minty, Sylvie Fournier, Daniel Caput,
Pascual Ferrara and Zhong C. Han A novel amber mutation in a B°-thalassaemia gene
(p°” TGG—TAG), with direct detection by mapping
Short Reports the restriction fragments in amplified DNA
Xiangmin Xu, Can Liao, Zhongying Liu,
928 Modulation of all-trans retinoid acid Jian Li, Zhaohui Peng, Luo-Lin Qiu
pharmacokinetics in acute promyelocytic and Jizeng Zhang
leukaemia by prolonged interferon-a therapy
Mario Lazzarino, Alessandro Corso, GM-CSE-induced acute eosinophilic pneumonia
Mario B. Regazzi, Isabella Iacona and Jorg Seebach, Rudolf Speich, Jérg Fehr,
Carlo Bernasconi Peter Tuchschmid and Erich Russi
xii Volume Contents
966 Molecular analysis of PML-RARa fusion mRNA Thrombocytopenic purpura
detected by reverse transcription-polymerase chain following treatment with danazol
reaction assay in long-term disease-free acute Francesco Laveder, Renzo Marcolongo
promyelocytic leukaemia patients and Sergio Zamboni
G. Martinelli, C. Remiddi, G. Visani, P. Farabegoli,
N. Testoni, A. Zaccaria, S. Manfroi, A. Cenacchi,
Etoposide (VP-16) inhibits Epstein-Barr virus
D. Russo, G. Bandini, M. Amabile, A. De Vivo
determined nuclear antigen (EBNA) synthesis
and S. Tura
Hideaki Kikuta, Yukio Sakiyama and Ih-Jen Su
m
Correspondence Book Revi. ews
969 Failure of Orgaran therapy in a patient with
a previous heparin-induced thrombocytopenia
Author and Keyword Indexes to Volume 90
syndrome
Brigitte Tardy/Poncet, Philippe Mahul,
Anne-Marie Beraud, Jean-Pierre Favre,
Bernard Tardy, Denis Guyotat and Beng H. Chong