British Journal of Haematology 1993: Vol 83 Table of Contents

9 Pages·1993·1.9 MB·English

BRITISH JOURNAL
OF
HAEMATOLOGY
EDITORIAL BOARD
EDITOR
I. R. PEAKE
ASSOCIATE EDITORS
A. K. Burnett, J. M. Chessells, M. Y. Gordon, M. Greaves, D. C. Linch, C. A. Ludlam,
S. J. Machin, J. A. PF. Napier, A. C. Newland, D. G. Oscier, N. Testa, M. Worwood, W. G. Wood
ANNOTATIONS EDITORS CLINICAL ANNOTATIONS EDITORS
M. K. Brenner and W. G. Wood J. M. Chessells and M. Pippard
A. V. Hofforand Chairman
E. Briet, M. K. Brenner, J. M. Goldman, E. C. Gordon-Smith, D. Hoelzer, B. Lowenberg,
L. Luzzatto, P. M. Mannucci, M. Pippard, E. G. D. Tuddenham,
H. van der Berghe, J. A. Whittaker
Volume 83
Pages 1-690
BLACKWELL SCIENTIFIC PUBLICATIONS
OXFORD LONDON EDINBURGH BOSTON MELBOURNE
1993
PUBLISHED BY BLACKWELL SCIENTIFIC PUBLICATIONS LTD, OSNEY MEAD, OXFORD
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Printed in Great Britain at The Alden Press, Oxford
BRITISH JOURNAL OF HAEMATOLOGY
Vol. 83 No. 1 January 1993 HIDEAKI ISHIKAWA, MicHIo M. KAWANO, KOSUKE
OKADA, HIDEO TANAKA, OSAMU TANABE, AKIRA
CLINICAL ANNOTATION. P. R. E. JOHNSON and SAKAI, HIDEKI ASAOKU, Koji IWATO, MASAHARU
J. A. Liu Yin. Acute myeloid leukaemia in the NosuyosuHi and AtsusHI KuRAMoTO. Expressions of
elderly: biology and treatment DNA topoisomerase I and II gene and the genes
PETER DREGER, KAREN GRELLE, VOLKER ECKSTEIN, possibly related to drug resistance in human
MEINOLF SUTTORP, WOLFGANG MiLLER-RUCHHOLTZ, myeloma cells
HELMUT LOFFLER and NORBERT SCHMITZ. P. M. VANHAGEN, E. P. KRENNING, J. C. REUBI,
Granulocyte-colony-stimulating factor induces A. H. Muper, W. H. BAKKER, H. Y. OI,
increased serum levels of soluble interleukin 2 B. LOWENBERG and S. W. J. LAMBERTS.
receptors preceding engraftment in autologous Somatostatin analogue scintigraphy of malignant
bone marrow transplantation lymphomas
GIORGIO ZAULI, GIUSEPPE VISANI, LUCIA CATANI, PAUL WARING, DOMINIC WALL, RAY DAUER,
NICOLA VIANELLI, LuIGI GUGLIOTTA and SILVANO DES PARKIN and DONALD METCALF. The effects of
CAPITANI. Reduced responsiveness of bone leukaemia inhibitory factor on platelet function
marrow megakaryocyte progenitors to platelet-
Aucusto B. FEDERICI, PHILIP G. DE Groot,
derived transforming factor 1, produced in
Marco Mora, M. J. W. IjssELDIJK, JAN J. SIXMA
normal amount, in patients with essential
and PrER MANNUCCIO MANNUCCI. Type I von
thrombocythaemia Willebrand disease, subtype ‘platelet low’:
YASUSHI TAKAMATSU, KOICHI AKASHI, MINE HARADA, decreased platelet adhesion can be explained by
TAKANORI TESHIMA, SHOICHI INABA, KAZUYA low synthesis of von Willebrand factor in
SHIMODA, TETSUYA ETO, TSUNEFUMI SHIBUYA, endothelial cells
SEIICHI OKAMURA and YOSHIYUKI NiHo. Cytokine
CHRISTINE GAUCHER, MICHEL HANss,
production by peripheral blood monocytes and
Marc DECHAVANNE and CLAUDINE MAZURIER.
T cells during haemopoietic recovery after
Substitution of cysteine for phenylalanine 751 in
intensive chemotherapy
mature von Willebrand factor is a novel
. R. ZEIGLER, C. S. ROSENFELD and R. K. SHADDUCK.
candidate mutation in a family with type ITA von
Resolution of transfusion dependence by
Willebrand disease
recombinant human erythropoietin (rHuEPO) in
KON-SIONG G. Jie, Brrcit L. M. G. GIJSBERS,
acquired pure red cell aplasia (PRCA) associated
Marjo H. J. KNAPEN, KARLY HAMULYAK,
with myeloid metaplasia
HERMAN L. FRANK and CEES VERMEER. Effects of
K. M. MAyNE, K. PULFORD, M. JONES, K. MICKLEM,
vitamin K and oral anticoagulants on urinary
G. NAGEL, C. E. VAN DER ScHooT and D. Y. MASON.
calcium excretion
Antibody By114 is selective for the 90 kD
PI-linked component of the CD66 antigen: a new CATHERINE Dopg£, RAJAGOPAL KRISHNAMOORTHY,
reagent for the study of paroxysmal nocturnal JANETTE LAMB and JACQUES ROCHETTE. Rapid
analysis of — «>? thalassaemia and aaa*™" >?
haemoglobinuria
triplication by enzymatic amplification analysis
A. BORKHARDT, R. REppP, J. HARBOTT, J. KREUDER and
F. LAMPERT. Quantification of leukaemic cells S. S. Cu1ou, T. T. CHANG, P. H. CHEN, L. S. LEE,
based on heteroduplex formation of tal-1 gene T. S. CHEN and J. G. CHANG. Molecular basis and
sequences after PCR coamplification haematological characterization of
K. PeNpRY, M. J. ALCORN and A. K. BURNETT. Factors B-thalassaemia major in Taiwan, with a
influencing haematological recovery in 53 mutation of IVS-1 3’ end TAG->GAG in a
patients with acute myeloid leukaemia in first Chinese patient
remission after autologous bone marrow PER LJUNGMAN, JOHAN ASCHAN, JOEY N. AZINGE,
transplantation LENA BRANDT, ANNEKA EHRNST, VIERA
YuicHt NAKAMURA, SHINSAKU HIROSAWA and Nosuo HAMMARSTROM, SVEN KLAESSON, ANNIKA LINDE,
Aoki. Consistent involvement of the 3’ half part BERIT LONNOVIST, OLLE RINGDEN, BRITTA WAHREN
of the first BCR intron in adult Philadelphia- and GéstA GAHRTON. Cytomegalovirus viraemia
positive leukaemia without M-bcr rearrangement and specific T-helper cell responses as predictors
J. T. Remy, D. BARNETT, G. DOLAN, P. FORREST, of disease after allogeneic marrow transplantation
J. EASTHAM and A. Smitu. Characterization of an O. LINDERKAMP, E. FRIEDERICHS, T. BOEHLER and
acute micromegakaryocytic leukaemia: evidence A. Lupwic. Age dependency of red blood cell
for the pathogenesis of myelofibrosis deformability and density: studies in transient
P. SONNEVELD, B. G. M. Durie, H. M. LOKHoRsT, erythroblastopenia of childhood
Y. FRUTIGER, M. SCHOESTER and E. E. VELA. DANIEL C. BETTICHER, HANSULI KELLER, FRIEDRICH
Analysis of multidrug-resistance (MDR-1) E. MALY and WALTER H. REINHART. The effect of
glycoprotein and CD56 expression to separate endotoxin and tumour necrosis factor on
monoclonal gammopathy from multiple myeloma erythrocyte and leucocyte deformability in vitro
iv Volume Contents
JANET WEAVER, Hul ZHAN and SIMEON POLLACK. Morio SAWAMURA, SAYURI YAMAGUCHI, KAYOKO
Erythrocyte haemolysate interacts with ATP-Fe MuRAYAMA, TAKAFUMI MATSUSHIMA, JUN’ICHI
to form a complex containing iron, ATP and 13 TAMURA, HIROKAZU MURAKAMI, TAKUJI NARUSE
800 MW polypeptide and JuN TsucutyA. Cyclosporine therapy for
A. BACIGALUPO, M. CHAPLE, J. Hows, M. T. VAN Langerhans cell histiocytosis
LINT, S. McCANN, D. MILLIGAN, J. CHESSELLS,
A. H. GOLDSTONE, J. OTTOLANDER, E. TH. VAN’T
VEER, B. Comotti, P. Coser, G. BrocctA, A. BosI,
A. LOCASCIULLI, L. CATALANO, R. BATTISTA,
W. ArcEsE, M. CAROTENUTO, A. M. MARMONT and
Vol. 83 No. 2 February 1993
E. C. GORDON SMITH. Treatment of aplastic
anaemia (AA) with antilymphocyte globulin
HENRIK S. BIRGENS and HANs KARLE. Reversible
(ALG) and methylprednisolone (MPred) with or
adult-onset cyclic haematopoiesis with a cycle
without androgens: a randomized trial from the
length of 100 days
EBMT SAA working party
M. AKER, A. ZIMRAN, A. ABRAHAMOV, M. Horowitz
F. LORENZO, E. MIRAGLIA DEL GIuDICE, N. ALLOISIO,
and Y. Matzner. Abnormal neutrophil
L. Morte, A. FORISSIER, S. PERROTTA,
chemotaxis in Gaucher disease
G. ScCIARRATA, A. IOLASCON and J. DELAUNAY.
EEVA JUVONEN, EERO IKKALA, KALEVI OKSANEN and
Severe poikilocytosis associated with a de novo
TAPANI Ruutu. Megakaryocyte and erythroid
«28 Arg—Cys mutation in spectrin
colony formation in essential thrombocythaemia
A. P. Grice, R. D. GAscoyneg, G. L. PHILLIPS and
and reactive thrombocytosis: diagnostic value
D. E. HorsMAN. Clinical, haematological and
and correlation to complications
cytogenetic features in 24 patients with
KATHLEEN V. WATSON and NIGEL Key. Vascular
structural rearrangements of the Q arm of
complications of essential thrombocythaemia: a
chromosome 3
link to cardiovascular risk factors
ALESSANDRO RAMBALDI, STEFANIA BETTONI, VINCENZO
SHORT REPORT Rossi, MARIA-LAURA TINI, GIOVANI GIUDICI,
Luce CONDAMINE, OLIVIER HERMINE, PATRICK ALVIN, VIRGINIA RIZZO, RENATO BASSAN, ALBERTO
MARTINE LEVINE, CAROLINE REY and VICTOR MANTOVANI, TIZIANO BARBUI and ANDREA BIONDI.
CoURTECUISSE. Acquired sideroblastic anaemia Transcriptional and post-transcriptional
during treatment of Wilson’s disease with regulation of IL-1, IL-6 and TNF-a genes in
triethylene tetramine dihydrochloride chronic lymphocytic leukaemia
MITSUHIRO MATSUDA, YASUHIRO MAEDA, CHIKASHI
SHIRAKAWA, HIDEYUKI MASAKI, ATSUKO KOYAMA,
CASE REPORTS FUSANARI HorIucHI, HIROYUKI HAMAZAKI, TAKUYA
A. M. StoppA, C. Fossat, D. SAINTy, D. BLAISE, FuJIMoTO, KrYOHIRO IRIMAJIRI and ATSUSHI
P. ViIENS, D. BAUME, M. Bayssas, I. JUHAN VAGUE Horiucui. CD3 down-regulating factor in sera
and D. MARANINCHI. In vivo administration of and culture supernatants of leukaemic cells from
recombinant granulocyte colony stimulating patients with adult T cell leukaemia
factor corrects acquired neutrophil function A. MESERI, V. DELWAIL, A. BRIZARD, J. C. LECRON,
deficiency associated with chronic graft-versus- D. PELLETIER, F. GUILHOT, J. TANZER and P. GOUBE
host disease DE LAFOREST. Endogenous lymphokine activated
Erik W. Mutter, Joost TH. M. DE WOLF and killer cell activity and cytogenetic response in
Epo VELLENGA. Successful immunosuppressive chronic myelogenous leukaemia treated with
treatment after failure of erythropoietin therapy a-interferon
in two subjects with refractory anaemia K. J. Tui, A. Lopez, J. SLupsky and J. C. CAWLEY.
C-fms protein expression by B-cells, with
particular reference to the hairy cells of hairy-cell
CORRESPONDENCE leukaemia
J. E. Humpuries, M. E. WILLIAMS, ANNA MARIA M. SCHWONZEN, C. POHL, T. STEINMETZ, W. SECKLER,
FERRARIS and GIAN FRANCO GAETANI. Detectability B. VETTEN, J. THIELE, D. WICKRAMANAYAKE and
of immunoglobulin and c-myc gene V. DrEHL. Immunophenotyping of low-grade
rearrangements in multiple myeloma B-cell lymphoma in blood and bone marrow: poor
M. K. Cook, F. G. Simpson, C. M. BoorHroyp and correlation between immunophenotype and
D. STainssy. Red cell macrocytosis and chronic cytological/histological classification
obstructive airways disease MELETIOS A. DIMOPOULOS, KAY B. DELASALLE,
D. G. OsctER, ANNE GARDINER, MARTIN DYER, RICHARD CHAMPLIN and RAYMOND ALEXANIAN.
M. JOTTERAND BELLOMO, D. MUHLEMATTER, Cyclophosphamide and etoposide therapy with
F. DELACRETAZ and P. M. Scumipr. t(8;9) in GM-CSF for VAD-resistant multiple myeloma
chronic myeloid leukaemia ANTONINO MAZZONE, GIOVANNI RICEVUTI, DAVIDE
SATOSHI IKUSHIMA, SHIGEYOSHI H1BI, YOSHIKO PASsoTTI, GIANLUCA FossATI, JOLANDA
KATAOKA, NAOHISA FujiTA and SHINSAKU MAZZUCCHELLI, PAOLA CAVIGLIANO and ANTONIA
IMASHUKU. Increase of gamma/delta T cells in Norario. The CD11/CD18 granulocyte adhesion
a case of typhoid fever molecules in myelodysplastic syndromes
Volume Contents
M. vAN MARWIJK Kooy, J. W. N. AKKERMAN, lymphoblastic leukaemia presenting with
S. VAN ASBECK, LIZETTE BORGHUIS and H. C. VAN relapsing hypoplastic anaemia: progression of the
PROOIJEN. UVB radiation exposes fibrinogen same abnormal clone 340
binding sites on platelets by activating protein JEAN-MICHEL PIGNON, EMMANUELLE POIRSON and
kinase C via reactive oxygen species HENRI ROCHANT. Danazol in autoimmune
TINA YEN, JOHN D. WALSH, GUNNAR PEJLER, MICHAEL haemolytic anaemia 343
C. BERNDT and CAROLYN L. GEczy. Cisplatin-
induced platelet activation requires mononuclear CASE REPORT
cells: role of GMP-140 and modulation of J. VEENSTRA, J. VAN DER LELIE, J. W. MULDER and
procoagulant activity P. Reiss. Low-grade thrombotic thrombocytopenic
MOHAMED HATMI, JACQUES RANDON, AHMAD FAILI purpura associated with HIV-1 infection 346
and B. Boris VARGAFTIG. Carrageenan-induced
activation of human platelets is dependent on the
CORRESPONDENCE
phospholipase C pathway
ALLISTAIR STARK, BARRY DALE and FRANCIS TOOLIS.
C. R. M. PRENTICE, K. K. HAMPTON, P. J. GRANT, Fluconazole chemoprophylaxis in neuiropenic
S. R. NELSON, W. NIEUWENHUIZEN and
patients 348
P. J. GAFENEY. The fibrinolytic response to ancrod
therapy: characterization of fibrinogen and fibrin
degradation products
Vol. 83 No. 3 March 1993
Harvey J. WEIss, BRUCE LAGES, WILLIAM VICIC,
LANcY Y. TsuNG and JAMES G. WHITE.
K. SawaDA, N. SATO, T. TARUMI, N. SAKAI,
Heterogeneous abnormalities of platelet dense
K. Korzumi, S. SAKURAMA, M. Ieko,
granule ultrastructure in 20 patients with
T. YASUKOUCHI, Y. KoYANAGAWA, M. YAMAGUCHI,
congenital storage pool deficiency
A. OumorTo, M. Kouno and T. KorkeE. Proliferation
Jute A. Hiccins, PAut L. F. GIANGRANDE, and differentiation of myelodysplastic CD34* cells
PETER B. A. KERNOFF and ALISON H. GOODALL
in serum-free medium: response to individual
Immunological effects of intermediate purity colony-stimulating factors
clotting factor concentrates: failure to affect
JEAN-PAUL FERMAND, MARIA-TERESA MITJAVILA,
lymphocyte activation in vivo
JEAN-PIERRE LE COUEDIC, ANDREAS TSAPIS,
R. KEKOMAKI, T. JOUHIKAINEN, J. OLLIKAINEN,
ROLAND BERGER, ROBERT MODIGLIANI, MAXIME
P. WESTMAN and M. Lass. A new platelet
SELIGMANN, JEAN-CLAUDE BROUET and WILLIAM
alloantigen, Tu*, on glycoprotein Illa associated
VAINCHENKER. Role of granulocyte-macrophage
with neonatal alloimmune thrombocytopenia in colony-stimulating factor, Interleukin-3 and
two families Interleukin-5 in the eosinophilia associated with
SuSAN J. THORPE and STUART W. BAILEY. T cell lymphoma
Demonstration of autoreactivity by a human
G. Barost, L. N. LIBERATO and R. GUARNONE. Serum
monoclonal IgG anti-Rh D antibody erythropoietin in patients with myelofibrosis with
CATHERINE NISSEN, ALOIS GRATWOHL, ANDRE myeloid metaplasia
TICHELLI, CHRISTINE STEBLER, ANDREAS WURSCH, D. BORDESSOULE, M. JONES, K. C. GATTER and
YOLANDA MOsER, VERENA DALLE CARBONARE, D. Y. MAson. Immunchistological patterns of
ERICH SIGNER, MAuRO BuseR, RUDOLF Ritz and myeloid antigens: tissue distribution of CD13,
BRUNO SPECK. Gender and response to CD14, CD16, CD31, CD36, CD65, CD66 and
antilymphocyte globulin (ALG) for severe aplastic
CD67
anaemia SHUICHI TANIGUCHI, TSUNEFUMI SHIBUYA,
. A. Lukin, A. A. LevinA, R. A. MOKEEVA and
MINE HARADA and YosHIYUKI NIHO. Decreased
Yu. N. ToKAREV. The diagnostic significance of tevels of myeloid progenitor cells associated with
serum ferritin indices in patients with malignant long-term administration of recombinant human
and reactive histiocytosis granulocyte colony-stimulating factor in patients
CAROLINE SABIN, ANDREW PHILLIPS, JONATHAN with automimmune neutropenia
ELFORD, PAUL GRIFFITHS, GEORGE JANOSSAY and SEIICHI OHMORI, MASAMI OHMORI,
CHRISTINE LEE. The progression of HIV disease in
MorIHISA YAMAGISHI and MINORU OKUMA.
a haemophilic cohort followed for 12 years
MDS-macrophage derived inhibitory activity on
myelopoiesis of MDS abnormal clones
METHODS PAPER ByorN K. ERIKSTEIN, HARALD HOLTE, STEIN KVALOyY,
A. R. MAGALINI, D. PRIMA, A. ALBERTINI, KRISTIN B. ANDERSSON, HARALD B. STEEN, EINER
A. Capucct, G. Rosst and G. MANTERO. Detection HANNISDAL and ERLEND B. SMELAND. Expression of
of BCR/ABL transcripts in chronic myeloid CD18 (integrin £2 chain) correlated with
leukaemia by polymerase chain reaction and prognosis in malignant B cell lymphomas
DNA enzyme immunoassay: a DNA probe assay O. KLoKE, N. NIEDERLE, J. Y. Qiu, U. WANDL,
without DNA labelling T. Moritz, M. NAGEL-HIEMKE, I. HAWIG,
B. OPALKA, S. SEEBER and R. BECHER. Impact of
SHORT REPORTS interferon alpha-induced cytogenetic
RAYMOND LIANG, GREGORY CHENG, M. S. WAT, improvement on survival in chronic myelogenous
S. Y. Ha and L. C. CHAN. Childhood acute leukaemia
vi Volume Contents
C. L. Davis, A. Z. S. ROHATINER, J. LIM, infection in patients undergoing therapy for
J. S. WHELAN, A. M. Oza, J. AmMess, S. LOVE, haematological malignancies: a clinical and
E. STeaD and T. A. Lister. The management of virological study
recurrent acute myelogenous leukaemia at a COLIN STEPHEN ScoTT, STEPHEN J. RICHARDS,
single centre over a fifteen-year period M. SIVAKURARAN, M. SHort, J. A. CHILD,
MICHAEL N. Porrer, COLIN G. STEWARD and Kay M. Hunt, M. McEvoy, ANDREW J. STEED,
ANTHONY OAKHILL. The significance of detection I. C. BALFour, L. A. PARAPIA, B. A. MCVERRY,
of minimal residual disease in childhood acute A. G. BYNoE, M. C. GALVIN, DEREK R. NORFOLK and
lymphoblastic leukaemia BRYON E. Roserts. Transient and persistent
K. A. NAsH, G. MOHAMMED, N. NANDAPALAN, expansions of large granular lymphocytes (LGL)
J. KERNAHAN, R. Scott, A. W. CRAFT and and NK-associated (NKa) cells: the Yorkshire
G. L. Tos. T cell function in children with acute Leukaemia Group study
lymphoblastic leukaemia
RuDOLF WEIDE, BEHNOUSH PARVIZ, KARL-HEINZ SHORT REPORT
PFLiiGER and KLAUS HAVEMANN. Altered BARBARA J. BAIN. Blood film features of sickle cell—
expression of the human retinoblastoma gene in haemoglobin C disease
monocytic leukaemias
G. GAstTL, M. PLANTE, C. L. FINsTAD, G. Y. WONG, CASE REPORT
M. G. Feperici, N. H. BANDER and S. C. RUBIN. RICARDO T. SPIELBERGER, JEROME I. DICKSTEIN,
High IL-6 levels in ascitic fluid correlate with MICHELLE M. LE BEAU, RICHARD A. LARSON,
reactive thrombocytosis in patients with epithelial KAREN M. DALY, JAMES W. VARDIMAN and
ovarian cancer Harvey M. Gotoms. Acute myeloid leukaemia
JIAN-MING Gu, WEN-FENG XU, XIAO-DONG WANG, following interferon-alfa treatment of hairy cell
QING-yU Wu, CHENG-wu CHI and CHANG-GENG leukaemia
RuAN. Identification of a nonsense mutation at
amino acid 584—Arginine of platelet glycoprotein CORRESPONDENCE
IIb in patients with type I Glanzmann DAvID J. FERGUSON, IRA A. SHULMAN,
thrombasthenia JANICE M. NELSON, SUNITA SAXENA, N. HEDDLE and
R. SCHWAAB, J. OLDENBURG, E. G. D. TUDDENHAM, J. G. KELTON. Omitting the antiglobulin
H. H. BRACKMANN and K. OLeEK. Mutations in crossmatch
haemophilia A V. Divoxy, L-H. Gu, K. INDRAK, K. MocIkova,
J. B. Porter, L. Youn, I. J. MAckrE, L. MARSHALL M. ZARNOVICANOVA and T. H. J. HUISMAN. A new
and S. J. MAcuin. Sickle cell disorders and B°-thalassaemia nonsense mutation (codon 112,
chronic intravascular haemolysis are associated T-—A) not associated with a dominant type of
with low plasma heparin cofactor II thalassaemia in the heterozygote
M. GALLI, E. M. Bevers, P. CoMFuRIuS, T. BARBUI H.-P. Horny, E. KAISERLING and G. H. GRIESSER.
and R. F. A. ZwAAL. Effect of antiphospholipid Human tissue mast cells in cases of cutaneous,
antibodies on procoagulant activity of activated systemic and malignant mastocytosis do not
platelets and platelet-derived microvesicles show immunohistochemically detectable
Fay Katz, IAN HANN, SALLY KINSEY, SARAH BALL, overexpression of p53 protein
GARETH MorRGAN and JUDITH CHESSELLS. . BERTOLINI, L. PoRRETTI, C. CORSINI, P. REBULLA
Assessment of graft status following allogeneic and G. SircuiA. Platelet quality and reduction of
bone marrow transplantation for haematological HLA expression in acid-treated platelet
disorders in children using locus-specific concentrates 525
minisatellite probes Book Reviews 528
YOSHIAKI FUKUDA, HIROYOSHI FUJITA, SHIGERU
TAKETANI and SHIGERU SASSA. Dimethyl
sulphoxide and haemin induce ferrochelatase Vol. 83 No. 4 April 1993
mRNA by different mechanisms in murine
erythroleukaemia cells ANNOTATION. ALAIN FIscHER. The use of
ALBERTO ZANELLA, ALESSANDRA BERZUINI, MARIA monoclonal antibodies in allogeneic bone
BERNADETTE COLOMBO, ANNA GUFFANTI, LUCILLA marrow transplantation
LECCHI, FRANCESCA POLI, MARIA DOMENICA MASANOBU KOBAYASHI, JUNJI TANAKA, MASAHIRO
CAPPELLINI and GIOVANNI BAROsI. Iron status in IMAMURA, SHIRO MAEDA, HIROSHI IWASAKI,
red cell pyruvate kinase deficiency: study of MASANORI TANAKA, YUUZOU TSUDA, KEISUKE
Italian cases SAKURADA and Tamotsu MryAzakI. Up-regulation
5. M. DoNOHUE, B. WONKE, A. V. HOFFBRAND, of IL-6-receptors by IL-3 on a plasma cell
J. Rerrrie, K. GANESHAGURU, P. J. SCHEUER, leukaemia cell line which proliferates dependently
D. BRowN and G. DusHeErko. Alpha interferon in on both IL-3 and IL-6
the treatment of chronic hepatitis C infection in SHOKO KOBAYASHI, MASANAO TERAMURA, SHIGERU
thalassaemia major HosHINO, TosHIKO Moroji, KAZUO OsHIMI and
N. S. BRINK, R. CHopra, C. J. PERRONS, C. J. A. RING, HIDEAKI Mi1zoGucui. Circulating megakaryocyte
J. A. Garson, E. M. Brices, A. H. GOLDSTONE, progenitors in myeloproliferative disorders are
D. C. LincH and R. S. TeppER. Acute hepatitis C hypersensitive to interleukin-3
Volume Contents Vii
GAYLE CociTA BALDWIN, GRACE Y. CHUNG, CARYN irradiation of platelets induces a dose-dependent
KASLANDER, TASNIM ESMAIL, RALPH A. REISFELD increase in the expression of platelet activation
and Davin W. Gotpe. Colony-stimulating factor markers with storage
enhancement of myeloid effector cell cytotoxicity PRANEE WINICHAGOON, VARAPORN THONGLAIROAM,
towards neuroectodermal tumour cells SUTHAT FUCHAROEN, PRAPON WILAIRAT, YASUYUKI
R. STARK, D. THIERRY, P. RICHARD and E. GLUCKMAN. FUKUMAKI and PRAWASE WaASI. Severity
Long-term bone marrow culture in Fanconi’s differences in B-thalassaemia/haemoglobin E
anaemia syndromes: implication of genetic factors
R. Stark, C. ANDRE, D. THIERRY, M. CHEREL, KAREN L. SMITH, TREVOR COBAIN and ROBERT A.
F. GALIBERT and E. GLUCKMAN. The expression of DuNsTAN. Removal of cytomegalovirus DNA from
cytokine and cytokine receptor genes in long- donor blood by filtration
term bone marrow culture in congenital and A. V. HOFFBRAND and B. F. A. JACKSON. Correction of
acquired bone marrow hypoplasias the DNA synthesis defect in vitamin B,»
JosEPH R. SLUPSKY, MARGARET DUGGAN-KEEN, deficiency by tetrahydrofolate: evidence in favour
LAURENCE A. BOOTH, ABRAHAM KARPAS, ELIZABETH of the methyl-folate trap hypothesis as the cause
G. H. RHODES, JOHN C. CAWLEY and MiRKO ZUZEL. of megaloblastic anaemia in vitamin B,;
The peanut-agglutinin (PNA)-vinding surface deficiency
components of malignant plasma cells SARAH SHAPIRO, DAVID KOHN and HARRIET GERSHON.
. N. WICKRAMASINGHE and R. HASAN. Possible role A role for complement as the major opsonin in
of macrophages in the pathogenesis of ethanol- the sequestration of erythrocytes from elderly and
induced bone marrow damage young donors
. LENORMAND, J. P. VANNTER, M. C. BENE, HANS KNECHT, DAvin J. L. JoskE, EpITH BACHMANN,
A. FALKENRODT, C. BAYLE, M. FAVRE, R. GARAND, FEDOR BACHMANN, BERNHARD F. ODERMATT and
A. M. GRIVEAU, M. T. Briqguet, O. REMAN, GorM PALLESEN. Expression of human
P. BouTARD, H. Titty, G. FAuRE and recombination activating genes (RAG-1 and
M. Monconbuit. CD2+ CD19+ acute RAG-2) in angioblastic lymphadenopathy and
lymphoblastic leukaemia in 16 children and anaplastic large cell lymphoma of T-type
adults: clinical and biological features
NoRIFUMI TSUKAMOTO, KIMIO MoRrITA,
TADASHI MAEHARA, KIYOSHI OKAMOTO, MASAMITSU SHORT REPORTS
KARASAWA, MITSUHIRO OMINE and TAKUJI SEITOKU FujIoKA and TERUO YAMADA. Decay-
NArRusE. Clonality in myelodysplastic syndromes: accelerating factor and CD59 expression in
demonstration of pluripotent stem cell origin peripheral blood cells in aplastic anaemia and
using X-linked restriction fragment length report of a case of paroxysmal nocturnal
polymorphisms haemoglobinuria secondary to aplastic anaemia
GIAMPAOLO MERLINI, VITTORIO PERFETTI, PAOLO G. A. G. BECHENSTEEN, T. R. J. LAPPIN, J. MARSDEN,
Gossli, SILVANA QUAGLINi, DIEGO M. FRANCIOTTA, D. MUGGLESTON and P. M. Cores. Unreliability in
GABRIELLA MARINONE and EDOARDO ASCARI. Acute immunoassays of erythropoietin: anomalous
phase proteins and prognosis in multiple estimates with an assay kit
myeloma TOHRU JUBASHI, KAZUHIRO NAGAI, YASUSHI
MARGARET SULLIVAN PEPE, GARY LONGTON, MIYAZAKI, HIDEO NAKAMURA, TATSUKI MATSUO,
MARY PETTINGER, MoToMI Mort, LLoyp D. FISHER KAZUTAKA KuRIYAMA and MASAO TOMONAGA.
and RAINER StorB. Summarizing data on A unique case of t(15;17) acute promyelocytic
survival, relapse, and chronic graft-versus-host leukaemia (M3) developing into acute
disease after bone marrow transplantation: myeloblastic leukaemia (M1) with t(7;21) at
motivation for and description of new methods relapse
BARRY WILBOURN, PAUL HARRISON, ANDREW LAWRIE, C. A. Scerri, W. ABELA, R. GALDIES, M. PizzuTo,
ELISABETH SAVARIAU, GEOFFREY SAVIDGE and J. L. GRecH and A. E. FEetice. The B* IVS, I-NT no.
ELISABETH MARTIN CRAMER. Porcine platelets 6 (TC) thalassaemia in heterozygotes with an
contain an increased quantity of ultra-high associated Hb Valletta or Hb S heterozygosity in
molecular weight von Willebrand factor and hcmozygotes from Malta
numerous alpha-granular tubular structures
AMANDA J. LEE, GORDON D. O. Lowe, WILLIAM C. S.
SMITH and HuGH TUNSTALL-PEDOE. Plasma CASE REPORTS
fibrinogen in women: relationships with oral PAOLO CORRADINI, DARIO FERRERO, CLAUDIA VOENA,
contraception, the menopause and hormone Marco LADETTO, MARIO BoccADORO and
replacement therapy ALESSANDRO PILERI. The mutation of N-ras
D. CARRIE, C. CARANOBE and B. BONEU. oncogene does not involve myeloid and erythroid
A comparison of the antithrombotic effects of lineages in a case of multiple myeloma
heparin and of low molecular weight heparins HiTOsHI TAKE, JUN’ICHI TAMURA, MorIo SAWAMURA,
with increasing antifactor Xa/antifactor Ia ratio HrrRoKAZU MURAKAMI, TAKujy! NARUSE, JUN
in the rabbit TsuUCHIYA, SHUICHI MIYAWAKI and HIsAMI
M. A. GRIJZENHOUT, M. I. AARTS-RIEMENS, HIRABAYASHI. Severe anaphylactic transfusion
J. W. N. AKKERMAN, H. K. NIEUWENHUIS, H. VAN reaction associated with HLA-incompatible
WEELDEN and H. C. VAN PROOIJEN. Ultraviolet-B platelets
Viii Volume Contents
DIANA SOUCEK, GERHARD RANSMAYR, KLAUS TWERDY, A. NIKKARI, O. MEURMAN, O. WANNE and
HEINZ ZWIERZINA, RICHARD GREIL, ESTHER FRITSCH, J. S. LILLEYMAN. Parvovirus B19 and transient
HANS Mater, ANTON PALLUA and FRANZ erythroblastopenia of childhood
GERSTENBRAND. Extensive meningeal involvement HirosH1 Onto, HrRoyASU YASUDA, RIKIYA ABE,
as the primary manifestation of a systemic small TOSHIYUKI ISHIBASHI, TSUTOMU SHICHISHIMA,
lymphocytic lymphoma: favourable outcome after YUKIO MARUYAMA, IWAO WATANABE, JOANNA M.
neuraxial irradiation without chemotherapy HEAL and Nem. BLUMBERG. Platelet transfusion
D. J. GRIMES, C. I. STAPLES, R. G. COBCROFT, refractoriness associated with plasma proteins
R. S. Boye and D. S. GitL. Complete remission of Book Reviews; Announcements; Errata
paraproteinaemia and neuropathy following Author and Subject Indexes to Volume 83
iatrogenic oral melphalan overdose
CORRESPONDENCE
ABDERRAHIM KHELiF, DAVID ASSOULINE, MARTINE
FFRENCH, GILLES CHAUMENTIN and JEAN-JACQUES
VIALA. Ticlopidine and aplastic anaemia