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The British Journal of Clinical Pharmacology Volume 51 2001 | | | Published for The British Pharmacological Society by Blackwell Science © 2001 Blackwell Science Ltd Osney Mead, Oxford OX2 OEIL 25 John Street, London WCIN 2BI 23 Ainslie Place, Edinburgh EH3 6AJ Commerce Place, 350 Main Street, Malden MA 02148-5018, USA 54 University Street, Carlton, Victoria 3053, Australia Other Editorial Offices Blackwell Wissenschafts-Verlag GmbH Kurfiirstendamm 57 1707 Berlin Germany Blackwell Science KK MG Kodenmacho Building 7-10 Kodenmacho Nihombashi Chuo-ku, Tokyo 104 Japan Published on behalf of The British Pharmacological Society All rights reserved. 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Special requests should be addressed to the Editor [ypeset, Printed and Bound by The Charlesworth Group, Huddersfield Contents RT This article is considered particularly suitable for continuing medical education. Volume 51, Number 1, January 2001 Editorial Population modelling of the effect of inogatran, at Genes for common disea thrombin inhibitor, on ex vivo coagulation time ptt) in healthy subjects and patients with coronary Review series irtery disease: M. Cullberg, U.G. Eriksson Csenes for common dise VI. Larsson & M.O. Karlssor V.J. Caulfield The genetics of essential hypertension Adverse drug reactions K.M. O’SI Attitudes of hospital pharmacists to adverse drug reaction reporting: C.F. Green, D.R. Mottram, Review P.H. Rowe & M. Pirmohamed Drug treatment of obesity: from past failures to Rusk factors in the development of adverse reactions to N-acetylcysteine in patients with paracetamol poisoning: L.E. Schmidt & K. Dalhoff Pharmacodynamics Effect of dexmedetomidine, an %-2 agonist, on Drug utilization pupillary reflexes during general anaesthesia Co-prescribing of ssris & tcas in Australia: how often does it occur and who is doing it? Pharmacodynamic models for the cardiovascular P. McManus, A. Mant, P. Mitchell, D. Bi cts of moxonidine in patients with congestive J. Dudley ilure: I irynne, J.L. McNay, H.G. Schaefer i & M.O. Karlssor Short reports Effect of &,-acid glycoprotein on the intracellular Drug disposition iccumulation of the hiv protease inhibitors hibition of CYP2D6 by haloperidol saquinavir, ritonavir and indinavir in vitro: K. Jones, tereoselective inhibition by reduced P.G. Hoggard, S. Khoo, B. Maher & D.J. Back G. Shin,K . Kane & D.A. Flockhart Systemic bioavailability of fluticasone propionate xycontinine: disposition kinetics, 1dministered as nasal drops and aqueous nasal spray fects, and plasma levels during cigarette smoking formulation: P.T. Daley- Yates & R.C. Baker N.L. Benowitz & P. Jacob Il Population pharmacokinetics Letter to the Editors Population pharmacokinetics of thioTEPA and its Terbinafine-associated inhibition on the ictive metabolite TEPA in patient undergoing high dextromethorphan metabolism in Chinese subjects chemotherapy: A.D.R. Huitema, R.A.A W.M. Cai, B. Chen, S.S. Ling & Y.D. Zhang VI.M. Tibben, ].H.M. Schellens, Rodenhui Announcements Volume 51, Number 2, February 2001 Commentary Disposition and metabolism of the flavonoid chrysin Journal impact factors: a ‘bioequivalence’ issue? in normal volunteers: T. Walle, Y. Otake, 1. Rostami-Hodjegan & G.T. Tucker ].A. Brubaker, U.K. Walle & P.V. Halushka Drug interaction Review The effects of lacidipine on the steady/state plasma Biomarkers for the effects of antipsychotic drugs in concentrations of simvastatin in healthy subjects healthy volunteers: S.J. de Visser,J . van der Post, L. Ziviani, L. Da Ros, L. Squassante, S. Milleri, V.S.M. Pieters, A.F. Cohen & ].M.A. van Gerven M. Cugola & L.E. lavarone Pharmacoepidemiology Drug disposition Effect of diuretics on fetal growth: A drug effect or Involvement of human cytochromes P450 in the confounding by indication? Pooled Danish and liver microsomal metabolism of astemizole and a Scottish cohort data: C. Olesen, C.S. de Vries, comparison with terfenadine: S. Matsumoto & N. Thrane, T.M. MacDonald, H. Larsen, Y. Yamazoe H.T. Sorensen & The EuroMAP Group Short reports Prescribing patterns in patients using new Nasal retention of budesonide and fluticasone in intidepressants | [ Vieijer, E.R Heerdink, Formation of airway mucosal budesonide L.P. Pepplinkhi van E1qgk & H.G.M vivo: H. Petersen, A. Kullberg, S. Edsbacker Leufkens eit Prescribers p1 people: The sources of Pharmacokinetics of sabeluzole and information used Dy doctors fo! prescribing su extromethorphan oxidation capacity in patient that the mediun more important tl in the dysfunction and healthy message [cG m, |. GoldenJ],.F ryer, R. ¢ lef, M. Barugola Nataf f 1, b Al le, I ( Ong, P. Bouh Influence of gender and oral contraceptiveosn Letters to the Editors CYP2D6 an YP2C19 activity in healthy The pharmacok tics of etanercept in patients volunteers: S. Hagg, O. Spigset & R. Dahilqvist with heart failu oran, A.M. Feldman, Acetysalicylic acid and other salicylates in relation VM. Sch / R lanna, D.L. Mant vens-Johnson syndrome and toxic epidermal ].M. Korth-B D.W. Kaufman & J.P. Kelly Non respo! a pharmacology ntrol Study commentary t ok review by D.N. Bateman I S701 Population pharmacokineti ictivation protein monoclonal er patients: P. Tar Book Review ig, S. Welt, ¢ Fundamenta f | honeuroimmunology Larso C.M. Pariai Volume 51, Number 3, March 2001 = Review Series Drug disposition Csenes for common Identification in t ytochrome P450 enzymes V.] Caulfield involved in the N-demethylation of sildenafil The R. Hy) S. Mer Drug interaction Review Evaluation o pharmacokinetic interaction Anti- TNF agents for rheumatoid arthritis between 1 le hydrochloride and H.E. Seymour, A. WV phenobarbito ealthy males: W.D. Hoop S.H.1 homa M.J. Eadic E. Blak ].A. Lockton & M Vianun’Eb Meeting report New insights into drug metabolism and toxicology Drug utilization Report of a symposium on drug metabolism and Outcomes of a randomized controlled trial of a toxicity held at the British Pharmacological Society Meeting in Cardiff, UK, in July 2001: M. A. Sh clinical phari ntervention in 52 nursing homes kes, M Pharmacokinetics The pharmacokinetics of methadone in HIV positive patients receiving the non-nucleoside reverse transcriptase inhibitor efavirenz Patterns of prescription and drug use in ophthalmology in a tertiary hospital in Delhi S.M. Clarke, F.M. Mulcahy, J. Tjia, H.t bbons, M.G. Barry & D.]. Back N.R. Biswa . lal, M.M. Siddiquei © R. Maini Pharmacodynamics Pharmacoepidemiology Responsiveness of human varicose saphenous veins Sudden unexpected death in infants under 3 months to vasoactive agents: F. Brunner, C. Hoffmann & of age and vaccination status 1 case-control study S hulle Petrovi 1.-P. Jonvil I jutret-Leca, F. Barbeillon, Assessment of forearm vasodilator responses to ]. Paris-Llado & the French Reference Centres for SIDS icetylcholine and albuterol by strain gauge plethysmography: reproducibility and influence of Short reports strain gauge placement: H.A. Walker, G. Jackson, Frequency of cytochrome P450 2C9 mutant alleles in ].M. Ritter & P.]. Chowienczyk a Korean population: Y.-R. Yoon, J.-H. Shon, M.-K. Kim, Y.-C. Lim, H.-R. Lee, J.-Y. Park, Pharmacokinetics/pharmacodynamics I.-]. Cha & ].-G. Shin Stereoselective halofantrine disposition and effect Involvement of human liver cytochrome P4502B6 in concentration-related QTc prolongation: the metabolism of propofol: Y. Oda, N. Hamaoka, D.R. Abernethy, D.L. Wesche, J.T. Barbey, C. Ohrt, I’. Hiroi, S. Imaoka, I. Hase, K. Tanaka, Y. Funae, S. Mohanty, J.C. Pezzullo & B.G. Schuster I. Ishizaki & A. Asada Volume 51, Number 4, April 2001 Editorial A placebo-controlled study examining the effect of Research methods in human respiratory Ulopurinol on heart rate variability and dysrhythmi: pharmacology: A.H. Morice counts in chronic heart failure: A.M.A. Shehab R. Butler, R.J ViacFadyen & A.D. Struthers Review series A dose-response study of adrenaline combined with Methods to identify drug deposition in the lungs lignocaine 2%: effect on acute postoperative pain following inhalation: H. Chrystyn after oral soft tissue surgery: L. Jorkjend & L.A. Skoglund Therapeutic drug monitoring Short reports Che role of therapeutic drug monitoring in Drug expenditure in hospitals: what do German treatment of HIV infection: D.]. Back, S.H. Khoo, ward physicians know?: J.U. Schnurrer, S.E. Gibbons & C. Merry D.O. Stichtenoth, R. Troost & J.C. Frélich Carbamazepine is not a substrate for P-glycoprotein Pharmacokinetics/pharmacodynamics 1. Owen, M. Pirmohamed, J].N. Tettey, P. Morgan, Lack of eftect of ondansetron on the D. Chadwick & B.K. Park pharmacokinetics and analgesic effects of morphine A single dose of methadone inhibits cytochrome ind metabolites after single-dose morphine P-4503A activity in healthy volunteers as assessed idministration in healthy volunteers: K.R. Crews by the urinary cortisol ratio: D.W. Boulton, B.P. Murthy, E.K. Hussey, A.N. Passannante, P. Arnaud & C.L. De Vane Effects of nociceptin and endomorphin 1 on the ].L. Palmer, W. Maixner & K.L.R. Brouwer electrically stimulated human vas deferens R. Bigoni, G. Calo, R. Guerrini, ].W. Strupish Pharmacodynamics D.]. Rowbotham & D.G. Lambert Dose requirement and prolactin elevation of Pharmacokinetics and systemic f,-adrenoceptot intipsychotics in male and female patients with mediated responses to inhaled salbutamol schizophreniao e& or rAell.a teRda mp sychoses: K.I. Melker S.J. Fowler & BJ Lipworth ed controll 1 assessment of the effects of Proceedings of the British Pharmacological regimens of budesonide on the Society, Clinical Pharmacology Section, I iealthy subjects: N. Andersson, University of Birmingham, 18-21 December L. Thersson 2000 Volume 51, Number 5, May 2001 Editorial Pharmacokinetics/pharmacodynamics Interim analyses in clinical trials: ] Concentration-effect relationships of two infusion S. Todd, A. Whitehead & N. Stallard rates of the imidazoline antihypertensive agent rilmenidine for blood pressure and development of Review series side-effects in healthy subjects: S.J. de Visser J.M.A. van Gerven, R.C. Schoemaker & A.F. Cohen Interim analyses and sequential designs in phase III] studies: S. Todd, A. Whitehead, N. Stallard & Drug interactions J. Whitehead The effect of anastrozole on the single-dose pharmacokinetics and anticoagulant activity of Pharmacokinetics warfarin in healthy volunteers: R.A. Yates,J ]. Wong, Beclomethasone dipropionate: absolute VM. Seiberling, M. Merz, W. Marz & M. Nauck bioavailability, pharmacokinetics and metabolism Effect of MAO-A inhibition on the following intravenous, oral, intranasal and inhaled pharmacokinetics of almotriptan, an antimigraine idministration in man: P.T. Daley-Yates, A.C. Price, agent in humans: J.C. Fleishaker, K.K. Ryan, ].R. Sisson, A. Pereira & N. Dallow J.M. Jansat, B.J. Carel, D.J.A. Bell, M.T. Burke & Influence of cirrhosis on lamotrigine N.E. Azie pharmacokinetics: P. Marcellin, F. de Bony, Effect of itraconazole on the pharmacokinetics of C. Garret, C. Altman, V. Boige, C. Castelnau, prednisolone and methylprednisolone and cortisol P. Laurent-PuiJg.,C . Trinchet, P. Rolan, C. Chen, secretion in healthy subjects: B. Lebrun- Vignes, ].P. Mamet & R. Bidault V. Corbrion Archer, B. Diquet, J.C. Levron, O. Chosidow, A.J. Puech & D. Warot Pharmacodynamics Drug disposition Dopamine D,-like receptors and amino acid- Enterocytic CYP3A4 in a paediatric population: induced glomerular hyperfiltration in humans: developmental changes and the effect of coeliac G. Luippold, S. Schneider, A. Stefanescu, P. Benéhr & disease and cystic fibrosis: T.N. Johnson, B. Miihlbauer M.S. Tanner, C.J. Taylor & G.T. Tucker 16] Inhibitory effects of verapamil and diltiazem on Influence of inhibition on salt-mediated simvastatin metabolism in human liver microsomes worsening of pulmonary gas exchange in heart K.R. Yeo & W.W. Yeo failure: M. Gua R. Brambilla, P. Agostoni é 4 M.D. Gua Short reports Letter to the Editors Mephenytoin as a probe for CYP2C19 Hepatitis B vac« ind first episodes of central phenotyping: effect of sample storage, intr nervous syste! yelinating disorders: a individual reproducibility and occurrence of adverse comparison between reported and expected number J. Tamminga, ]. Wemer, B. Oosterhuts, of cases: A. Fou B. Begaud, A. Alperovitch, D.]. Touw, R.A. de Zeenw, L.F.M.H. di M.-H. Verd r, E. Touze, N. Decker& Jonkman J.-L. Iml s of thiopurine S-methyltransferase les (TPMT *2, *3A, *3B and *3C) in Book reviews Japanese subjects and the inheritance of A textbook of | pharmacology: G.A family of a propositus: 7. Kubota Drug interactions and infectious diseases G.M. Shenf nd its metabolite quinaprilat in human 1. Robson, S.]. Gardiner, Proceedings of the Dutch Society for Clinical on, E.L. Post Pharmacology and Biopharmacy, 2 October 2000 Volume 51, Number 6, June 2001 = Review series Comparison fects of nadolol and bisoprolol Resear Viethods in Huma diovascular on the isopr ‘voked dilatation of the dorsal Pharmacology edited by Dr S. Maxwell and Prof hand vein in mat H. Abdelmawla, R.V Langley, D. Webb. Pulse wave analysis: M.F. O'Rourke E. Szabadi & & X.-]. Jiang g rules for phase II studies: N id, S. Todd & A. Whitehead Drug interactions Pharmacokine eraction between mefloquine Pharmacokinetics 6-Thioguanine in children with acute lymphoblastic and ritonavir in healthy volunteers: Y. Khaliq, influence of food on parent drug lale, G. Carignan, C pharmacokinetics and 6-thioguanine nucleotide mcentrations: D.L. Lancaster, N. Patel, L. Leni & J.S. I eyman Oral bioavailability of dihydroartemisinin 1n Pharmacovigilance Vietnamese volunteers and in patients with Public health impact of adverse bone eftects of oral falciparum malaria: T.Q. Binh, K.F. Ilett, corticosteroids: T.P. van Staa, L. Abenhaim, K.T. Batty, T.M.E. Davis, N.C. Hung, S.M. Powell C. Cooper, B. Zhang & H.G.M. Leufkens L.T.A. Thu, H.V. Thien, H.L. Phuong& A 6-month large-scale study into the safety of V.D.B. Phuong tamsulosin: .V.¢ Michel, H.-U. Bressel, M. Goepelé Simultaneous administration of a cocktail of markers H. Riibben to measure renal drug elimination pathways ibsence of a pharmacokinetic interaction between fluconazole and sinistrin, p-aminohippuric acid and Drug utilization pindolol: A.S. Gro 1.]. McLachlan, I. Minns, Drug therapy in the elderly: what doctors believe ].B. Beal & S.E. Tett ind patients actually do: I. Barat, F. Andreasen & E.M.S. Damsgaard Population pharmacokinetics Increased oral ganciclovir bioavailability in HIV infected patients with chronic diarrhoea and wasting Short reports yndrome—a population pharmacokinetic study Recording previous adverse drug reactions—a gap S. Mouly, G tard. |.- Tillement, C. Caulin, in the system: G.M. Shenfield, T. Robb & M. Duguid ].-F. Bergemann & Is cytochrome P450 2C9 genotype associated with Population pharmacokinetics of carbamazepine in NSAID gastric ulceration?: J.H. Martin, E.J. Begg, Singapore epileptic patients: E. Chan, H.S. Lee & M.A. Kennedy, R. Roberts & M.L. Barclay S.S. Hue The effect of fluconazole on ritonavir and Pharmacodynamics saquinavir pharmacokinetics in HIV-1-infected Platelet CD62 expression and PDOGFa, secretion in individuals: C.H.W. Koks, K.M.L. Crommentuyn, patients undergoing PTCA and treatment with R.M.W. Hoetelmans, D.M. Burger, P.P. Koopmans, ibeiximab: J. Graff, D. Andries, M. Elsner, R.A.A. Mathot, ].W. Mulder, P.L. Meenhorst & D. Westrup, S. Bassus, N. Franz, U. Klinkhardt& ].H. Beijnen S. Harder Indices for Volume 51