British Journal of Clinical Pharmacology 1994: Vol 37 Table of Contents

5 Pages·1994·2 MB·English

Contents
Volume 37, Number 1, January 1994
Papers Oxidative activation of proguanil and dapsone
The pharmacokinetics of piroxicam in elderly acetylation in Thai soldiers: M. D. Edstein,
persons with and without renal impairment: G. D. Shanks, P. Teja-Isavadharm,
A. C. Rudy, N. L. Figueroa, S. D. Hall & K. H. Rieckmann & H. K. Webster
D. C. Brater Disposition of clozapine in man: lack of association
Zidovudine pharmacokinetics in zidovudine- with debrisoquine and S-mephenytoin
induced bone marrow toxicity: M. Barry, hydroxylation polymorphisms: M.-L. Dahl,
J. L. Howe, D. J. Back, A. M. Swart, A. Llerena, U. Bondesson, L. Lindstrém &
A. M. Breckenridge, I. V. D. Weller, N. Beeching L. Bertilsson
& F. Nye The pharmacokinetics of ketorolac enantiomers
Examination of some factors responsible for a food- following intramuscular administration of the
induced increase in absorption of atovaquone: racemate: P. J. Hayball, J. Wrobel, J. G. Tamblyn
P. E. Rolan, A. J. Mercer, B. C. Weatherley, & R. L. Nation
T. Holdich, H. Meire, R. W. Peck, G. Ridout & Neither cimetidine nor probenecid affect the
J. Posner pharmacokinetics of tenoxicam in normal
The influence of gender and sex steroid hormones volunteers: R. O. Day, G. Geisslinger, P. Paull &
on the plasma binding of propranolol enantiomers: K. M. Williams
U. K. Walle, T. C. Fagan, M. J. Topmiller, The effect of ferrous sulphate on the absorption of
E. C. Conradi & T. Walle norfloxacin, ciprofloxacin and ofloxacin: P. Lehto,
A double-blind, placebo-controlled interaction K. T. Kivist6 & P. J. Neuvonen
study between oxcarbazepine and carbamazepine, Plasma concentrations of betamethasone after
sodium valproate and phenytoin in epileptic topical application of betamethasone 17-valerate:
patients: P. J. W. McKee, J. Blacklaw, G. Forrest, comparison with oral administration: K. Kubota,
R. A. Gillham, S. M. Walker, D. Connelly & E. S. Lo, G. Huttinot, P. H. Andersen &
M. J. Brodie H. I. Maibach
Acoustic rhinometry compared with posterior Blood concentrations of dopexamine in patients
rhinomanometry in the measurement of histamine- during and after orthotopic liver transplantation:
and bradykinin-induced changes in nasal airway P. A. Gray, T. Jones & G. R. Park
patency: C. E. Austin & J. C. Foreman Pharmacokinetic study of yohimbine and its
The effects of a peripherally selective a>- pharmacodynamic effects on salivary secretion in
adrenoceptor antagonist, MK-467, on the metabolic patients treated with tricyclic antidepressants:
and cardiovascular response to exercise in healthy H. Bagheri, P. Picault, L. Schmitt, G. Houin,
man: D. G. Sciberras, J. W. Reed, C. Elliott, M. Berlan & J. L. Montastruc
P. G. Blain & M. R. Goldberg Effects of a thromboxane receptor antagonist on
An assessment of lacidipine and atenolol in mild to prostaglandin D> and histamine induced
moderate hypertension: D. Lyons, G. Fowler, bronchoconstriction in man: N. Al Jarad, K. P. Hui
J. Webster, S. T. Hall & J. C. Petrie & N. Barnes
8-adrenoceptor blockers in atrial fibrillation: the
importance of partial agonist activity: Letters to the Editors
K. S. Channer, M. A. James, T. MacConnell & Good clinical practice—a question of balance:
J. R. Rees M. J. VandenBurg & M. E. Allen: A. E. Wallnéfer
Colestipol at varying dosage intervals in the & A. F. Cohen
treatment of moderate hypercholesterolaemia:
D. Lyons, J. Webster, G. Fowler & J. C. Petrie Book reviews
Molecular aspects of anticancer drugs-DNA
interactions. Volume 1: L. Lennard
ABC of monitoring drug therapy: M. P. Feely
Short reports
Effects of ACE inhibitors on oxidation of human Proceedings
low density lipoprotein: E. G. Godfrey, J. Stewart, Proceedings of the British Pharmacological Society
H. J. Dargie, J. L. Reid, M. Dominiczak, (14-16 September 1993, Catholic University of the
C. A. Hamilton & J. McMurray Sacred Heart, Rome).
Volume 37, Number 2, February 1994
Review Education
125 Plasma protein binding displacement interactions— 129 I. Clinical pharmacology and therapeutics in under-
why are they still regarded as clinically important?: graduate medical education in the UK: current status:
P.E. Rolan T. Walley, J. Bligh, M. Orme & A. Breckenridge
II. Clinical pharmacology and therapeutics in under- on cough during upper respiratory tract infections:
graduate medical education in the UK: the future: R. Lowry, A. Wood & T. Higenbottam
T. Walley, J. Bligh, M. Orme & A. Breckenridge The renal clearance of cefuroxime and ceftazidine
and the effect of probenecid on their tubular
excretion: C. A. Verhagen, H. Mattie & E. Van Strijen
Papers Does tachyphylaxis occur to the non-pulmonary
Pharmacokinetic and -dynamic studies with a new effects of salmeterol?: J. G. Maconochie, N. A.
anxiolytic, suriclone, utilizing EEG mapping and Minton, J. E. Chilton & O. N. Keene
psychometry: B. Saletu, J. Griinberger, L. Linzmayer,
H. V. Semlitsch, P. Anderer & K. Chwatal Short reports
EEG profile of litoxetine after single and repeated Interaction between tolbutamide and ketoconazole
administration in healthy volunteers: A. Patat, in healthy subjects: Y. §. R. Krishnaiah,
S. Trocherie, J. J. Thébault, P. Rosenzweig, S. Satyanarayana & D. Visweswaram
C. Dubruc, G. Bianchetti, P. L. Morselli & Inhibition of gastric alcohol dehydrogenase
L. A. Court activity by histamine H>-receptor antagonists has no
Psychomotor performance and antihypertensive influence on the pharmacokinetics of ethanol after a
treatment: L. Kalra, C. G. Swift & S. H. D. Jackson moderate dose: A. Mallat, F. Roudot-Thoraval,
Inhibitory effects of calcium antagonists on J.-F. Bergmann, H. Trout, G. Simonneau,
at-adrenoceptor-mediated contraction in the human C. Dutreuil, L. Elouaer Blanc, D. Dhumeaux &
internal mammary artery: G.-W. He, T. E. Acuff, J.-C. Delchier
W. H. Ryan, C.-Q. Yang, M. B. Douthit, Population genetics of the angiotensin-converting
R.T. Bowman & M. J. Mack enzyme in Chinese: E. J. D. Lee
Comparison of the effects of acute fluvoxamine and
desipramine administration on melatonin and cortisol Book review
production in humans: D. J. Skene, C. J. Bojkowski Potassium channel modulators: pharmacological,
& J. Arendt molecular and clinical aspects. Edited by
The effect of anticholinergic bronchodilator therapy A. H. Weston and T. C. Hamilton: §. H. D. Jackson
Volume 37, Number 3, March 1994
Leading article
217 ‘The strategy of desire’ and rational prescribing: The acute effects of a single dopamine infusion in
D.K. Scott & R. E. Ferner elderly patients with congestive heart failure:
T. Robinson, S. Gariballa, G. Fancourt, J. Potter &
Papers M. Castleden
Dose of midazolam should be reduced during Dose finding studies with imidapril—a new ACE
diltiazem and verapamil treatments: J. T. Backman, inhibitor: M. J. Vandenburg, E. M. Mackay, I. Dews,
K. T. Olkkola, K. Aranko, J.-J. Himberg & T. Pullan & S. Brugier
P. J. Neuvonen Comparative effects of angiotensin II on Doppler
The efficacy of locally applied morphine in post- parameters of left and right heart systolic and
operative pain after bilateral third molar surgery: diastolic blood flow: B. J. Lipworth & K. D. Dagg
U.J. Moore, R. A. Seymour, J. Gilroy & Trimetazidine: a new concept in the treatment of
M. D. Rawlins angina. Comparison with propranolol in patients with
Do cholesterol-lowering agents affect brain activity? stable angina: J. M. Detry, P. Sellier, S. Pennaforte,
A comparison of simvastatin, pravastatin, and placebo D. Cokkinos, H. Dargie & P. Mathes
in healthy volunteers: R. W. S. Harrison & Failure to reproduce the in vitro cardiac electro-
C. H. Ashton physiological effects of naloxone in humans:
The role of S-mephenytoin 4'-hydroxylase in K. G. Oldroyd, A. C. Rankin, C. E. Gray, K. Harvey,
imipramine metabolism by human liver microsomes: W. Borland, A. P. Rae & S. M. Cobbe
a two-enzyme kinetic analysis of N-demethylation and
2-hydroxylation: K. Chiba, A. Saitoh, E. Koyama, Short reports
M. Tani, M. Hayashi & T. Ishizaki Cefpiramide kinetics and plasma protein binding
Pharmacokinetics of rac-leucovorin vs [S]-leucovorin in cholestasis: F. Demotes-Mainard, G. Vingon,
in patients with advanced gastrointestinal cancer: L. Labat, M. Amouretti, J. Necciari, G. Kieffer &
R. M. Mader, G. G. Steger, B. Rizovski, A. E. Sieder, B. Bannwarth
G. Locker, M. F. X. Gnant, R. Jakesz & H. Rainer The effect of liver disease and food on plasma MEGX
Pharmacokinetics of artemether after oral concentrations: R. Pritchard-Davies, A. S. Gross &
administration to healthy Thai males and patients with G. M. Shenfteld
acute, uncomplicated falciparum malaria: The pharmacokinetics of quinapril and quinaprilat
K. Na Bangchang, J. Karbwang, C. G. Thomas, in patients with congestive heart failure: FE. J. Begg,
A. Thanavibul, K. Sukontason, §. A. Ward & R.A. Robson, H. Ikram, A. M. Richards,
G. Edwards J. A. Bammert-Adams, S.C. Olson, E. L. Posvar,
Multicentre hospital drug utilization study on the P.A. Reece & A. J. Sedman
prophylaxis of venous thromboembolism: The Venous The effect of physiological manoeuvres on the
Thromboembolism Study Group of the Spanish absorption of inhaled nedocromil sodium:
Society of Clinical Pharmacology S. K. Ghosh, M. G. Neale & K. R. Patel
Volume 37, Number 4, April 1994
Editorial
309 Clinical pharmacology with confidence: P. C. Waller, BRL35135 in man: N. M. Wheeldon, D. G. McDevitt
P.R. Jackson, G. T. Tucker & L. E. Ramsay & B. J. Lipworth
Lack of effect of H>-receptor antagonists on the
pharmacokinetics of alcohol consumed after food at
Review
lunchtime: M. J. Kendall, F. Spannuth, R. P. Walt,
Drugs and insulin resistance: clinical methods of
G. J. Gibson, K. A. Hale, R. Braithwaite &
evaluation and new pharmacological approaches to
M.J.S. Langman
metabolism: R. Donnelly & A. D. Morris
Liver blood flow, antipyrine clearance, and antipyrine
metabolite formation clearance in patients with
Papers chronic active hepatitis and alcoholic cirrhosis:
The effect of low dose lofepramine in depressed L. A. Bauer, T. O'Sullivan, W. G. Reiss, J. R. Horn,
elderly patients in general medical wards: K. Opheim, D. E. Strandness & R. L. Carithers
R.S.H.Tan, R. J. Barlow, C. Abel, S. Reddy, Maprotiline metabolism appears to co-segregate with
A.J. Palmer, A. E. Fletcher, C. G. Nicholl, the genetically-determined CYP2D6 polymorphic
B.M.N. Pitt & C.J. Bulpitt hydroxylation of debrisoquine: L. Firkusny &
A comparison of the antinociceptive effects of C. H. Gleiter
imipramine, tramadol and anpirtoline: T. Hummel,
C. Hummel, 1. Friedel, E. Pauli & G. Kobal Short reports
Effects on platelet functions and pharmacokinetics of The pharmacokinetics of ondansetron after intra-
azapropazone and ketorolac tromethamine given as venous injection in healthy volunteers phenotyped
single parenteral doses: D. Pallapies, B. A. Peskar, as poor or extensive metabolisers of debrisoquine:
K. Brune & G. Geisslinger E.1.L. Ashforth, J. L. Palmer, A. Bye & A. Bedding
Isolated circulatory response to intravenous admin- Stereoselective disposition of flurbiprofen in healthy
istration of the ACE inhibitor enalaprilat: J. Boldt, subjects following administration of the single
Ch. Knothe, F. Schindler, W. A. Stertmann & enantiomers: G. Geisslinger, J. Létsch, S. Menzel,
G. Hempelmann G. Kobal & K. Brune
Effects of acute B-adrenoceptor blockade with Clinical evaluation of pain during subcutaneous
metoprolol on the renal response to dopamine in injections of low molecular weight heparins in
normal humans: N. V. Olsen, T. Lang-Jensen, healthy volunteers: N. Billon, F. Gloaguen,
J.M. Hansen, 1. Plum, J. K. Thomsen, S. Strandgaard C. Funck-Brentano & P. Jaillon
& P. P. Leyssac
Interactive effects of indomethacin, angiotensin II Letter to the Editors
and frusemide on renal haemodynamics and natri- Training medical professionals on the concepts of
uresis in man: J. G. Motwani & A. D. Struthers essential drugs and rational drug use: J. S. Bapna,
Cardiac effects of the B;-adrenoceptor agonist D. G. Shewade & S.C. Pradhan
Volume 37, Number 5, May 1994
Conference report
401 International conference on harmonisation of tech- Dose-related effects of ibuprofen on pain-related
nical requirements for registration of pharmaceuticals potentials: G. Kobal, C. Hummel, M. Gruber,
for human use (ICH): N. Baber G. Geisslinger & T. Hummel
Papers
Biotransformation of caffeine in human liver micro- Short reports
somes from foetuses, neonates, infants and adults: Methotrexate disposition following concomitant
C. Cazeneuve, G. Pons, E. Rey, J.-M. Treluyer, administration of ketoprofen, piroxicam and
T. Cresteil, G. Thiroux, P. D’Athis & G. Olive flurbiprofen in patients with rheumatoid arthritis:
In vitro proguanil activation to cycloguanil by human T. §. Tracy, T. Worster, J. D. Bradley, P. K. Greene
liver microsomes is mediated by CYP3A isoforms as & D.C. Brater
well as by S-mephenytoin hydroxylase: D. J. Birkett, Trilinolein improves erythrocyte deformability during
D. Rees, T. Andersson, F. J. Gonzalez, J. O. Miners & cardiopulmonary bypass: S. K. Tsai, P. Chan,
M. E. Veronese T. Y. Lee, J. M. Yung & C. Y. Hong
Pharmacokinetics of zidovudine and dideoxyinosine Preliminary investigation of the efficacy of sub-
alone and in combination in patients with the lingual verapamil in the management of acute atrial
acquired immunodeficiency syndrome: M. Barry, fibrillation and flutter: S. Fort, M. J. Lewis,
J.L. Howe, S. Ormesher, D. J. Back, D. K. Luscombe & D. N. John
A. M. Breckenridge, C. Bergin, F. Mulcahy, The interaction of paracetamol with frusemide:
N. Beeching & F. Nye U. Martin & L. F. Prescott
Between-subject and within-subject variations in
the pharmacokinetics of ethanol: A. W. Jones &
K. A. Jonsson Letter to the Editors
Monoamine oxidase-A: pharmacodynamics in HIV screening in ‘healthy’ volunteers and Ethics
humans of moclobemide, a reversible and selective Committees: J. Sanchez, A. Costa, A. Fresquet,
inhibitor: N. H. G. Holford, T. W. Guentert, M. Abadias & A. Bartlett
J. Dingemanse & L. Banken Proceedings of the British Pharmacological Society
Lack of tolerance in forearm blood vessels in man to (Charing Cross and Westminster Medical School,
glyceryl trinitrate: A. R. Cheesman & N. Benjamin 5-7 January 1994)
Volume 37, Number 6, June 1994
Review
Volunteer models for predicting antiemetic activity of subjects: D. Westerling, P. Hdglund, S. Lundin &
5-HT3-receptor antagonists: N. A. Minton P. Svedman
Lymphocyte microsomal epoxide hydrolase in
Commentary patients on carbamazepine therapy: M. Pirmohamed,
Fixed combinations of neuroleptics with antidepres- R. Allott, V. J. Green, N. R. Kitteringham,
sants: potential risks and estimation of use: D. Chadwick & B. K. Park
A. Llerena & R. A. Kiivet Influence of sex-steroid hormones on the regulation
of lymphocyte B>-adrenoceptors during the menstrual
Papers cycle: N. M. Wheeldon, D. M. Newnham,
Concurrent use of more than one major psychotropic W. J. Coutie, J. A. Peters, D.G. McDevitt &
drug (polypsychopharmacy) in out-patients—a B. J. Lipworth
prescription database study: J.-U. Rosholm, Intestinal drug absorption during induced net water
J. Hallas & L. F. Gram absorption in man: a mechanistic study using
Effects of zolpidem on sleep architecture, night time antipyrine, atenolol and enalaprilat: H. Lennernds,
ventilation, daytime vigilance and performance in O. Ahrenstedt & A. L. Ungell
heavy snorers: M. A. Quera-Salva, C. McCann, Identification of human liver cytochrome P450 iso-
J. Boudet, M. Frisk, P. Borderies & Ph. Meyer forms mediating secondary omeprazole metabolism:
Mixed linear and non-linear disposition of lazabe- T. Andersson, J. O. Miners, M. E. Veronese &
mide, a reversible and selective inhibitor of D. J. Birkett
monoamine oxidase B: T. W. Guentert, N. H. G. Hol-
ford, J. P. Pfefen & J. Dingemanse Short reports
Pharmacodynamics of lazabemide, a reversible and Frequency of human CYP2D6 mutant alleles in a
selective inhibitor of monoamine oxidase B: normal Chinese population: E. J. D. Lee & K.
N.H. G. Holford, T. W. Guentert, J. Dingemanse & Jeyaseelan
R. Kettler Paracetamol absorption from different sites in the
Decreased plasma protein binding of valproate in human small intestine: T. Gramatté & K. Richter
patients with acute head trauma: G. D. Anderson,
B. E. Gidal, R. J. Hendryx, A. B. Awan, N. R. Temkin, Letters to the Editors
A. J. Wilensky & H.R. Winn B-adrenoceptor blockers in atrial fibrillation: the
Disposition of warfarin enantiomers and metabolites importance of partial agonist activity: A. Herxheimer:
in patients during multiple dosing with rac-warfarin: K. S. Channer
F. Chan, A. J. McLachlan, M. Pegg, A. D. MacKay,
R. B. Cole & M. Rowland Indexes
Transdermal administration of morphine to healthy Author and Subject indexes to Volume 37