Breath Analysis - For Clinical Diagnosis, Theraputic Monitoring - A. Amann, D. Smith (World, 2005) WW

557 Pages·2005·8.53 MB·English

Breath Analysis

for Clinical Diagnosis and
Therapeutic Monitoring

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This page intentionally left blank

Breath Analysis

for Clinical Diagnosis and
Therapeutic Monitoring

editors

Anton Amann
Innsbruck Medical University and
ETH-Zurich

David Smith
Keele University, UK

vp World Scientific

NEW JERSEY - LONDON - SINGAPORE - BElJlNG - SHANGHAI * HONG KONG * TAIPEI * CHENNAI

Published by

World Scientific Publishing Co. Pte. Ltd.

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UK ofice: 57 Shelton Street, Covent Garden, London WC2H 9HE

British Library Cataloguing-in-Publication Data
A catalogue record for this book is available from the British Library.

BREATH ANALYSIS FOR CLINICAL DIAGNOSIS AND
THERAPEUTIC MONITORING (With CD-ROM)

Copyright 0
2005 by World Scientific Publishing Co. Pte. Ltd.

All rights reserved. This book, or parts thereoj muy not be reproduced in any form or by any means,
electronic or mechanical, including photocopying, recording or any information storage and retrieval
system now known or to be invented, without written permission from the Publisher.

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ISBN 981-256-284-2

Printed in Singapore by World Scientific Printers ( S ) Pte Ltd

CONTENTS

Foreword

Part A. New Analytical Techniques

1.

2.

3.

4.

5.

6,

Selected Ion Flow Tube Mass Spectromet,ry, SIFT-MS,
for On-Line Trace Gas Analysis of Breath
D. Smith, P. Spandl

Occupational Exposure Assessment Through Analysis of Human
Breath and Ambient Air Using IMR-Mass Spectrometry
J. Villinger, S. Praun, J. Rossler-Gruf, A . Dornauer,
H. Neumager, E. Baumgartrier

Proton Transfer R,eaction Time-of-Flight Mass Spectrometry:
A Good Prospect for Diagnostic Breath Analysis?
R. S. Blake, C. Whyte, P. S. Monks, A.M. Ellis

Metabolites in Human Breath: Ion Mobility Spectrometers as
Diagnostic Tools for Lung Diseases
J. I. Baumbach, W. Vautz, V. Ruzsanyi, L. Freitag

Laser Spectroscopic On-Line Monitoring of Exhaled Trace Gases
G. von Busum, D. Hulmer, P. Hering, M. Murtz

Exhaled Human Breath Analysis with Quantum Cascade
Laser-Based Gas Sensors
G. Wysocki, M. McCurdy, S. So, C. Roller, F. K. Tittel

xi

1

3

35

45

53

67

75

V

vi
Contents

7. TCNQ Derivatives-Based Sensors for Breath Gas Analysis
85
G. V. Karnarchuk, 0. P. Pospyelov, Yu. L. Alexandrov,
A . V. Yerernenko, A . V. Kruvchenko, E. G. Kushch,
L. V. Kamarchuk, E. Faulques

Part B. Nitric Oxide, Carbon Monoxide, and Ethane
101

8. Exhaled Nitric Oxide: How and Why We Know It Is Important
L. E. Gusta.fsson
103

9. Nitric Oxide in Exhaled Breath: A Window on Lung Physiology

R. A . Dweik
and Pulmonary Disease
121

10. Nasal Nitric Oxide Measurements as a Diagnostic Tool:
Ready for Clinical Use?
141
J. 0. Lundberg

11. Exhaled Nitric Oxide in Hepatopulmonary Syndrome
147
G. Rolla

12. Exhaled Nitric Oxide and Pulmonary Complications after
Allogeneic Stem Cell Transplantation
C. Bucca, L. Brussino, E. Panaro, G. Aitoro, L. Giaccone,
B. Bruno

155

13. Isotope Selective Detection of Nitric Oxide in Human Exhalation 161
J. Lauenstein. K.-H. Gericke

14. Diagnostic Aspects of Exhaled Nitric Oxide in
Cardiothoracic Anaesthesia
A. Szabd, T. Kovesi, J. Gd, D. Royston, N. Murczin
171

15. Can Inhalation Carbon Monoxide be Utilized as a Therapeutic
Modality in Human Diseases?
203
T. Dolinay, A. M. K. Choi, S. W. Ryter

Contents vii

16. Breath Ethane in Disease: Methods for Analysis Based on
Room Air Correction
237
K. A. Cope

Part C. Broadly-Based Studies
249

17. Current Status of Clinical Breath Analysis
T. H. Ris b y

18. VOC Breath Markers in Critically I11 Patients:
Potential and Limitations
J. K. Schubert, W. Miekisch, G. F. E. Noldge-Schomburg

25 1

267

19. How to Analyze Breath and Make Sense of the Data:
A Personal View
293
M. Phillips

20. Exhaled Breath Gas as a Biochemical Probe During Sleep
A. Amann, S. Telser, L. Hofer, A. Schmid, H. Hintehuber
305

21. Analysis of Breath Using SIFT-MS: A Comparison of the
Breath Composition of Healthy Volunteers and Seriously-I11
ICU Patients
317
G. Turner, S. Welch, G. Bellingan, M . Singer, P. Span61, D. Smith

22. Breath Gas Analysis and Vector-Borne Disease Diagnosis:
The Case of Malaria
327
B. G. J. Knols

23. Recent Developments in Exhaled Breath Analysis and
Human Exposure Research
337
A. B. Lindstrom

24. The Unique Value of Breath Biomarkers for Estimating
Pharmacokinetic Rate Constants and Body Burden from

J. D. Pleil, D. Kim, J. D. Prah, D. L. Ashley, S. M. Rappaport
Environmental Exposure
347

viii
Contents

25. A Model of the Cardiovascular-Respiratory Control System with
Applications to Exercise, Sleep, and Congestive Heart Failure
S. Teschl, J. Batzel, F. Kappel

Part D. Focused Studies

26. Breath Gas Analysis in Patients with
Carbohydrate-Malabsorption Syndrome
M. Ledochowski, A. Amann, D. Fuchs

27. Detection of H. pylori Infection by Breath Ammonia Following
Urea Ingestion
C. Penault, P. Spanel, D. Smith

28. Breath Gas Analysis in Patients Suffering from
Propionic Acidaemia
U. Janovsky, S. Scholl-Biirgi, D. Karall, J. Beauchamp,
A. Hansel, G. Poupart, A. Schmid, A. Amann

29. Applications of Selected Ion Flow Tube Mass Spectrometry in
Addiction Research
R. Bloor, T. S. Wang, P. Spandl, D. Smith

30. Exhaled Breath Condensate (EBC):
An Alternative or Additional Diagnostic?
G. Becher, M. Rothe, M. Decker

31. Rapid Diagnosis of Gastro-Intestinal Infection Using
Faecal Odour
R. Ewen, B. de Lacy Costello, C. Garner, N. M. Ratclifle,
S. Smit, S. J. Probert

Part E. Use of Isotopes

32. Flowing Afterglow Mass Spectrometry (FA-MS) for the
Determination of the Deuterium Abundance in Breath Water
Vapour and Aqueous Liquid Headspace
P. Spanel, D. Smith

361

373

375

393

40 1

409

42 1

429

437

439

Contents ix

33. 13C Breath Tests: Transition from Research to Clinical Practice
457
A. S. Modalc

34. The Combined Use of SIFT-MS and FA-MS to Investigate
First-Pass Metabolism of Ethanol
479
T. S. Wang, P. Spanel, D. Smith

Part F. Animal Studies
49 1

35. Breath Analysis: Taking the Needle Out of
Veterinary Diagnostics?
493
C. A. Wyse, K. D. Slceldon, A. J. Cathcart, R. Sutherland,
S. A. Ward, G. Gibson, L. C. McMillan, M. J. Padgett,
T. Preston, P. S. Yam, S. Love

36. Potential for and Limitations of Exhaled Breath Analysis in
Animal Models
P. Reinhold, C. Deaton, D. Marlin
503

515
Index