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Breath Analysis - For Clinical Diagnosis, Theraputic Monitoring - A. Amann, D. Smith (World, 2005) WW PDF

557 Pages·2005·8.53 MB·English
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Breath Analysis for Clinical Diagnosis and Therapeutic Monitoring This page intentionally left blank This page intentionally left blank Breath Analysis for Clinical Diagnosis and Therapeutic Monitoring editors Anton Amann Innsbruck Medical University and ETH-Zurich David Smith Keele University, UK vp World Scientific NEW JERSEY - LONDON - SINGAPORE - BElJlNG - SHANGHAI * HONG KONG * TAIPEI * CHENNAI Published by World Scientific Publishing Co. Pte. Ltd. 5 Toh Tuck Link, Singapore 596224 USA ofice: 27 Warren Street, Suite 401-402, Hackensack, NJ 07601 UK ofice: 57 Shelton Street, Covent Garden, London WC2H 9HE British Library Cataloguing-in-Publication Data A catalogue record for this book is available from the British Library. BREATH ANALYSIS FOR CLINICAL DIAGNOSIS AND THERAPEUTIC MONITORING (With CD-ROM) Copyright 0 2005 by World Scientific Publishing Co. Pte. Ltd. All rights reserved. This book, or parts thereoj muy not be reproduced in any form or by any means, electronic or mechanical, including photocopying, recording or any information storage and retrieval system now known or to be invented, without written permission from the Publisher. For photocopying of material in this volume, please pay a copying fee through the Copyright Clearance Center, Inc., 222 Rosewood Drive, Danvers, MA 01923, USA. In this case permission to photocopy is not required from the publisher. ISBN 981-256-284-2 Printed in Singapore by World Scientific Printers ( S ) Pte Ltd CONTENTS Foreword Part A. New Analytical Techniques 1. 2. 3. 4. 5. 6, Selected Ion Flow Tube Mass Spectromet,ry, SIFT-MS, for On-Line Trace Gas Analysis of Breath D. Smith, P. Spandl Occupational Exposure Assessment Through Analysis of Human Breath and Ambient Air Using IMR-Mass Spectrometry J. Villinger, S. Praun, J. Rossler-Gruf, A . Dornauer, H. Neumager, E. Baumgartrier Proton Transfer R,eaction Time-of-Flight Mass Spectrometry: A Good Prospect for Diagnostic Breath Analysis? R. S. Blake, C. Whyte, P. S. Monks, A.M. Ellis Metabolites in Human Breath: Ion Mobility Spectrometers as Diagnostic Tools for Lung Diseases J. I. Baumbach, W. Vautz, V. Ruzsanyi, L. Freitag Laser Spectroscopic On-Line Monitoring of Exhaled Trace Gases G. von Busum, D. Hulmer, P. Hering, M. Murtz Exhaled Human Breath Analysis with Quantum Cascade Laser-Based Gas Sensors G. Wysocki, M. McCurdy, S. So, C. Roller, F. K. Tittel xi 1 3 35 45 53 67 75 V vi Contents 7. TCNQ Derivatives-Based Sensors for Breath Gas Analysis 85 G. V. Karnarchuk, 0. P. Pospyelov, Yu. L. Alexandrov, A . V. Yerernenko, A . V. Kruvchenko, E. G. Kushch, L. V. Kamarchuk, E. Faulques Part B. Nitric Oxide, Carbon Monoxide, and Ethane 101 8. Exhaled Nitric Oxide: How and Why We Know It Is Important L. E. Gusta.fsson 103 9. Nitric Oxide in Exhaled Breath: A Window on Lung Physiology R. A . Dweik and Pulmonary Disease 121 10. Nasal Nitric Oxide Measurements as a Diagnostic Tool: Ready for Clinical Use? 141 J. 0. Lundberg 11. Exhaled Nitric Oxide in Hepatopulmonary Syndrome 147 G. Rolla 12. Exhaled Nitric Oxide and Pulmonary Complications after Allogeneic Stem Cell Transplantation C. Bucca, L. Brussino, E. Panaro, G. Aitoro, L. Giaccone, B. Bruno 155 13. Isotope Selective Detection of Nitric Oxide in Human Exhalation 161 J. Lauenstein. K.-H. Gericke 14. Diagnostic Aspects of Exhaled Nitric Oxide in Cardiothoracic Anaesthesia A. Szabd, T. Kovesi, J. Gd, D. Royston, N. Murczin 171 15. Can Inhalation Carbon Monoxide be Utilized as a Therapeutic Modality in Human Diseases? 203 T. Dolinay, A. M. K. Choi, S. W. Ryter Contents vii 16. Breath Ethane in Disease: Methods for Analysis Based on Room Air Correction 237 K. A. Cope Part C. Broadly-Based Studies 249 17. Current Status of Clinical Breath Analysis T. H. Ris b y 18. VOC Breath Markers in Critically I11 Patients: Potential and Limitations J. K. Schubert, W. Miekisch, G. F. E. Noldge-Schomburg 25 1 267 19. How to Analyze Breath and Make Sense of the Data: A Personal View 293 M. Phillips 20. Exhaled Breath Gas as a Biochemical Probe During Sleep A. Amann, S. Telser, L. Hofer, A. Schmid, H. Hintehuber 305 21. Analysis of Breath Using SIFT-MS: A Comparison of the Breath Composition of Healthy Volunteers and Seriously-I11 ICU Patients 317 G. Turner, S. Welch, G. Bellingan, M . Singer, P. Span61, D. Smith 22. Breath Gas Analysis and Vector-Borne Disease Diagnosis: The Case of Malaria 327 B. G. J. Knols 23. Recent Developments in Exhaled Breath Analysis and Human Exposure Research 337 A. B. Lindstrom 24. The Unique Value of Breath Biomarkers for Estimating Pharmacokinetic Rate Constants and Body Burden from J. D. Pleil, D. Kim, J. D. Prah, D. L. Ashley, S. M. Rappaport Environmental Exposure 347 viii Contents 25. A Model of the Cardiovascular-Respiratory Control System with Applications to Exercise, Sleep, and Congestive Heart Failure S. Teschl, J. Batzel, F. Kappel Part D. Focused Studies 26. Breath Gas Analysis in Patients with Carbohydrate-Malabsorption Syndrome M. Ledochowski, A. Amann, D. Fuchs 27. Detection of H. pylori Infection by Breath Ammonia Following Urea Ingestion C. Penault, P. Spanel, D. Smith 28. Breath Gas Analysis in Patients Suffering from Propionic Acidaemia U. Janovsky, S. Scholl-Biirgi, D. Karall, J. Beauchamp, A. Hansel, G. Poupart, A. Schmid, A. Amann 29. Applications of Selected Ion Flow Tube Mass Spectrometry in Addiction Research R. Bloor, T. S. Wang, P. Spandl, D. Smith 30. Exhaled Breath Condensate (EBC): An Alternative or Additional Diagnostic? G. Becher, M. Rothe, M. Decker 31. Rapid Diagnosis of Gastro-Intestinal Infection Using Faecal Odour R. Ewen, B. de Lacy Costello, C. Garner, N. M. Ratclifle, S. Smit, S. J. Probert Part E. Use of Isotopes 32. Flowing Afterglow Mass Spectrometry (FA-MS) for the Determination of the Deuterium Abundance in Breath Water Vapour and Aqueous Liquid Headspace P. Spanel, D. Smith 361 373 375 393 40 1 409 42 1 429 437 439 Contents ix 33. 13C Breath Tests: Transition from Research to Clinical Practice 457 A. S. Modalc 34. The Combined Use of SIFT-MS and FA-MS to Investigate First-Pass Metabolism of Ethanol 479 T. S. Wang, P. Spanel, D. Smith Part F. Animal Studies 49 1 35. Breath Analysis: Taking the Needle Out of Veterinary Diagnostics? 493 C. A. Wyse, K. D. Slceldon, A. J. Cathcart, R. Sutherland, S. A. Ward, G. Gibson, L. C. McMillan, M. J. Padgett, T. Preston, P. S. Yam, S. Love 36. Potential for and Limitations of Exhaled Breath Analysis in Animal Models P. Reinhold, C. Deaton, D. Marlin 503 515 Index

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