Breast Cancer: Biological and Clinical Progress: Proceedings of the Conference of the International Association for Breast Cancer Research, St. Vincent, Aosta Valley, Italy, May 26–29, 1991

311 Pages·1992·12.81 MB·English

by  Demetrios A. Spandidos (auth.), L. Dogliotti, A. Sapino, G. Bussolati (eds.)

BREAST CANCER: BIOLOGICAL AND CLINICAL PROGRESS
Developments in Oncology
49. K.H. Hollmann and J.M. Verley (eds.): New Frontiers in Mammary Pathology. 1986
ISBN 0-89838-852-X
50. DJ. Ruiter, GJ. Fleuren and S.O. Wamaar (eds.): Application ofM onoclonal
Antibodies in Tumor Pathology. 1987 ISBN 0-89838-853-8
51. A.H.G. Paterson and A.W. Lees (eds.): Fundamental Problems in Breast Cancer. 1987
ISBN 0-89838-863-5
52. M. Chatel, E Darcel and J. Pecker (eds.): Brain Oncology. Biology, Diagnosis and
Therapy. 1987 ISBN 0-89838-954-2
53. M.P. Hacker, J.S. Lazo and T.R. Tritton (eds.): Organ Directed Toxicities ofA nticancer
Drugs. 1988. ISBN 0-89838-356-0
54. M. Nicolini (ed.): Platinum and Other Metal Coordination Compounds in Cancer
Chemotherapy. 1988 ISBN 0-89838-358-7
55. J.R. Ryan and L.O. Baker (eds.): Recent Concepts in Sarcoma Treatment. 1988
ISBN 0-89838-376-5
56. M.A. Rich, J.C. Hager and D.M. Lopez (eds.): Breast Cancer. Scientific and Clinical
Aspects.1988 ISBN 0-89838-387-0
57. B.A StoU (ed.): Women at High Risk to Breast Cancer. 1989 ISBN 0-89838-416-8
58. M.A. Rich, J.C. Hager and I. Keydar (eds.): Breast Cancer. Progress in Biology, Clinical
Management and Prevention. 1989 ISBN 0-7923-0507-8
59. P.I. Reed, M. Carboni, BJ. Johnston and S. Guadagni (eds.): New Trends in Gastric
Cancer. Background and Videosurgery. 1990 ISBN 0-7923-8917-4
60. H.K. Awwad: Radiation Oncology: Radiobiological and Phsyiological Perspectives.
The Boundary-Zone between Clinical Radiotherapy and Fundamental Radiobiology and
Physiology.1990 ISBN 0-7923-0783-6
61. J.L. Evelhoch, W. Negendank, F.A. Valeriote and L.H. Baker (eds.): Magnetic
Resonance in Experimental anii Clinical Oncology. 1990 ISBN 0-7923-0935-9
62. B.A. StoU (ed.): Approaches to Breast Cancer Prevention. 1991 ISBN 0-7923-0995-2
63. MJ. Hill and A. Giacosa, (eds.): Causation and Prevention ofH uman Cancer.
ISBN 0-7923-1084-5
64. J.R.W. Masters (ed.): Human Cancer in Primary Culture. A Handbook. 1991
ISBN 0-7923-1088-8
65. N. Kobayashi, T. Akera and S. Mizutani (eds.): Childhood Leukemia. Present Problems
and Future Prospects. 1991 ISBN 0-7923-1138-8
66. P. Paoletti, K. Takakura, M.D. Wa1ker, G. Butti and S. Pezzotta (eds.): Neuro-oncology.
1991 ISBN 0-7923-1215-5
67. K.V. Honn, LJ. Mamett, S. Nigam and T. Walden Jr. (eds.): Eicosanoids and Other
Bioactive Lipids in Cancer and Radiation lnjury. 1991 ISBN 0-7923-1303~8
68. EA. Valeriote, T.H. Corbett and L.H. Baker (eds.): Cytotoxic Antican(;er Drugs: Models
and Concepts for Drug Discovery and Development. 1992 ISBN 0-7923-1629-0
SPRINGER SCIENCE+BUSINESS MEDIA, LLC
BREAST CANCER: BIOLOGICAL ANO CLINICAL PROGRESS
Proceedings of the Conference of the International Association
for Breast Cancer Research, st. Vincent, Aosta Valley,
Italy, May 26-29, 1991
Edited by:
L. Oogliotti
A. Sapino
G. Bussolati
~.
Springer Science+Business Media, LLC
"
Library of Congress Cataloging-in-Publication Data
International Association for Breast Cancer Research. Conference
(1991: Saint-Vmcent, ltaIy)
Breast cancer: biological and clinical progress : proceedings of
the Conference of the International Association for Breast Cancer
Research, SI. Vmcent Aosta Valley, Italy, May 26-29, 1991/ edited
by L. Dogliotti, A. Sapino, G. Bussolati.
p. cm. - (Developments in oncology ; 69)
ISBN 978-1-4613-6549-5 ISBN 978-1-4615-3494-5 (eBook)
DOI 10.1007/978-1-4615-3494-5
1. Breast-Cancer-Congresses. 1. Dogliotti, Luigi. ll. Sapino,
A. ill. Bussolati, G. IV. TItle. V. Series.
[DNI.M: 1. Breast NeopIasms-pathology-congresses. 2. Breast
Neoplasms-physiopathology-congresses. 3. Breast Neoplasms-
-therapy-congresses. WI DE998N v. 69/ WP 870 1578b 1991]
RC280.B8I54 1991
616.99'449-dc20
DNI.MlDLC
for Library of Congress 92-7660
CIP
Copyright © 1992 by Springer Science+Business Media New York
Originally published by Kluwer Academic Publishers in 1992
Softcover reprint ofthe hardcover lst edition 1992
AlI rights reserved. No pari of this publication may be reproduced, stored in a retrieval system or transmitted in
any form or by any means, mechanical, photocopying, recording, or otherwise, without the prior written
permission of the publisher, Springer Science+Business Media, LLC.
CONTENTS
Contributors ix
Preface xvii
I. ACTIVATION OF CELLULAR ONCOGENES 1
1. The Role of Oncogenes and Onco-Suppressor Genes
in Human Breast Cancer. 3
D.A. Spandidos
2. Expression of the MET Oncogene in Human Tumors 11
M.F. Di Renzo, M. Prat, M. Olivero, T. Crepaldi, and
P.M. Comoglio
3. c-erbB-2, a Tyrosine Kinase Growth Factor
Receptor and its Role in Breast Cancer 23
F.J. Lofts and w.J. Gullick
4. Mammary Morphogenesis and Oncogenes 41
R.D. Cardiff, D. Ornitz, F. Lee, R. Moreadith, E. Sinn,
W. Muller, and P. Leder
II . POLYPEPTIDES AND GROWTH FACTORS EXPRESSION 57
5. Interdependence of Hormones and Growth Factors in
Lobulo-Alveolar Development of the Mammary Gland
and Tumorigenesis 59
B.K. Vonderhaar and K. Plaut
VI
6. The Role of Estrogen Regulated Secreted Proteins
for Growth Regulation of Human Breast Cancer 81
A. Lykkesfeldt, I. Laursen, and P. Briand
7. The Prolactin-Inducible Protein I Gross Cystic
Disease Fluid Protein (PIP/GCDFP-15): Genetic
Analysis and Hormonal Regulation of Gene
Expression 93
R.P.G. Shiu, Y. Myal, D. Tsuyuki, D. Robinson, B.
Iwasiow, A. Yarmill, and P. Watson
III. MAMMARY EPITHELIUM AND STROMA IN VIVO AND IN 103
VITRO
8. Role of RAS Oncogene in Human Breast Cancer: an
Experimental Approach 105
J. Russo, G. Galaf, J. Ochieng, I.H. Russo, Q. Tahin,
and P. -L. Zhang
9. Interactions Between Malignant and Non-Malignant
Components of the Breast 119
WR. Miller
10. Involvement of Heparanase and Extracellular
Matrix-Bound Fibroblast Growth Factor in Tumor
Progression 137
I. Vlodavsky, R. Ishai-Michaeli, M. Mohsen, G.
Korner, and R. Gatane
Vll
IV. HORMONE RESPONSIVENESS AND ORAL
CONTRACEPTIVES 151
11. Estrogen and Progesterone Receptor Activity in
Breast Cancer Cells 153
S. Bettuzzi, A. Robinson, R. Fuchs-Young, and G.
Greene
12. Oral Contraceptives and Breast Cancer: the Scope
for a Hypothesis-Oriented Approach 169
C. La Vecchia
V. RISK FACTORS; MONITORING OF BREAST CANCER
PROGRESSION AND REGRESSION 179
13. Benign Breast Disease: Links to Risk of Cancer 181
D.L. Page and W. D. Dupont
14. Proliferation Rate in Different Cell Types in Benign
Breast Disease 195
A. Sapino, L. Macri, P. Gugliotta, C. Manini, and G.
Bussolati
15. Aspects of Cell Mediated Immunity in Monitoring
Breast Cancer 207
U. Koldovsky
16. New Approaches to the Study of Selenium's
Chemopreventive Properties 225
D. Medina, R. Mukhopadhyay, and M. Bansal
Vlll
VI. BIOLOGICAL FACTORS OF PROGNOSIS; THE
METASTATIC PHENOTYPE 233
17. Cell Kinetics as an Indicator for Prognosis and
Therapy 235
R. Silvestrini
18. Cathepsin D and Breast Cancer Metastasis:
Biological and Clinical Significance 243
M. Garcia, G. Capony, and H. Rochefort
19. Diagnostic tools and prognostic factors in human
breast cancer evaluated by morphological and
immunohistochemical methods 255
A. Schauer, D. Marx, I. Lipp, M. Schumacher, W.
Sauerbrei, H. Rauschecker, and R. Sauer
VII.THERAPEUTIC STRATEGIES IN BREAST CANCER
TREATMENT 277
20. Oestrogen-Deprivation in Breast Cancer: Clinical
and Experimental Observations 279
R.I. Nicholson and D.L. Manning
21. Polyamines and Growth Factors as Possible Targets
for Antitumor Therapy in Breast Cancer 291
A. Manni
22. New Diagnostic Methods and Treatment Modalities
in Breast Cancer 301
J.G.M. Klijn, P.M.J.J. Berns, M. Bontenbal, J.
Alexieva-Figusch, and J.A. Foekens
CONTRIBUTORS
J. Alexieva-Figusch, Dept. of Medical Oncology, The Dr.
Daniel den Hoed, Cancer Center, PO Box 5201, 3008 AE
Rotterdam, The Netherlands
M. Bansal, Dept. of Cell Biology, Baylor College of Medicine,
Texas Medical Center, Houston, Texas 77030, USA
P.M.J.J. Berns, Dept. of Medical Oncology, The Dr. Daniel den
Hoed, Cancer Center, PO Box 5201, 3008 AE Rotterdam, The
Netherlands
S. BeUuzzi, Universita di Modena, Istituto Chimica Biologica,
41100 Modena, Italy
M. Bontenbal, Dept. of Medical Oncology, The Dr. Daniel den
Hoed, Cancer Center, PO Box 5201, 3008 AE Rotterdam, The
Netherlands
P. Briand, Lab. of Tumor Endocrinology, The Fibiger Institute,
The Danish Center Society, DK- 2100, Conpenhagen, Denmark
G. Bussolati, Dept. of Biomedical Sciences and Human
Oncology, University of Turin, Via Santena 7, 10126 Torino,
Italy
G. Calaf, Dept. of Pathology, Fox Chase Cancer Center, 7701
Burholme Avenue, Philadelphia, PA 19111, USA
G. Capony, Universite de Montpellier, INSERM U 148, 60 rue de
Navacelles, 34100 Montpellier Cedex, France
x
R.D. Cardiff, Department of Pathology, University of
California Medical School, Room 3453, Med. Sci. 1-A, Davis, CA
95616, USA
R. Catane, Dept. Radiation and Clinical Oncology, Hadassah
University Hospital, Jerusalem, 91120 Israel
P. Comoglio, Dept. Biomedical Sciences, C.so Massimo
d'Azeglio 52, 10126 Torino, Italy
T. Crepaldi, Dept. Biomedical Sciences, C.so Massimo
d'Azeglio 52, 10126 Torino, Italy
M.F. Di Renzo, Dept. Biomedical Sciences, C.so Massimo
d'Azeglio 52, 10126 Torino, Italy
W.O. Dupont, Dept. of Pathol. and Preventive Medicine,
Vand erbilt, University Medical Center, C-3321, Nashville,
Tennessee 37232, USA
J.A. Foekens, Dept. of Medical Oncology, The Dr. Daniel den
Hoed, Cancer Center, PO Box 5201, 3008 AE Rotterdam, The
Netherlands
R. Fuchs-Young, The Ben May Lab. for Cancer Research, 950
East 59th Street, Chicago, Illinois 60637, USA
M. Garcia, Universite de Montpellier, INSERM U 148, 60 rue de
Navacelles, 34100 Montpellier Cedex, France
G. Greene, The Ben May Lab. for Cancer Research, 950 East