Brain Edema XII: Proceedings of the 12th International Symposium, Hakone, Japan, November 10–13, 2002

551 Pages·2003·20.118 MB·English

by  Riki Okeda (auth.), T. Kuroiwa, A. Baethmann, Z. Czernicki, J. T. Hoff, U. Ito, Y. Katayama, A. Marmarou, B. A. D. Mendelow, H.-J. Reulen (eds.)

Acta Neurochirurgica
Supplements
Editor: H.-J. Steiger
Brain Edema XII
Proceedings of the 12th International Symposium,
Hakone, Japan, November 10-13, 2002
Edited by
T. Kuroiwa, A. Baethmann, Z. Czernicki,
J. T. Hoff, U. Ito, Y. Katayama, A. Marmarou,
A. D. Mendelow, and H.-J. Reulen
Acta Ne urochirurgica
Supplement 86
Springer-Verlag Wien GmbH
T. Kuroiwa y. Katayama
Medical Research Institute, Department ofNeurological Surgery,
Tokyo Medical and Dental University, Nihon University, Tokyo, Japan
Tokyo, Japan
A. Marmarou
A. Baethmann Medical College of Virgina,
Institute für Chirurgische Forschung, Richmond, USA
Ludwig-Maximilians-Universität,
München, Germany
B. A. D. Mendelow
Department ofNeurosurgery,
Z. Czernicki Newcastle Gerneral Hospital, Newcastle-upon-Tyne, UK
Department ofNeurosurgery,
Polish Academy of Scienes, Warsaw, Poland
H.-J. Reulen
Neurochirurgische Universitätklinik, .
J. T. Hoff Ludwig-Maximilians-Universität,
Section ofNeurosurgery, München, Germany
U niversity of Michigan, Ann Arbor, USA
U. Ito
Department of N eurosurgery,
Musashino Red Cross Hospital, Tokyo, Japan
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© 2003 Springer-Verlag Wien
Originally published by Springer-Verlag / Wien in 2000
Softcover reprint of the hardcover 1s t edition 2000
Typesetting: Asco Typesetters, Hong Kong
Printed on acid-free and chlorine-free bleached paper
SPIN: 10905760
With partly coloured Figures
Library of Congress Cataloging-in-Publication Data
Brain edema XII: proceedings ofthe 12th international symposium: Hakone, Japan,
November 10-13, 2002/ edited by T. Kuroiwa ... let al.].
p. ; cm. - (Acta neurochirurgica. Supplement, ISSN 0065-1419 ; 86)
Includes bibliographical references and index.
ISBN 978-3-7091-7220-9 ISBN 978-3-7091-0651-8 (eBook)
DOI 10.1007/978-3-7091-0651-8
1. Cerebral edema-Congresses. I. Title: Brain edema 12. II. Kuroiwa, T. III. Series.
[DNLM: 1. Brain Edema-Congresses. WL 348 B8137 2003]
RC394.E3B7272 2003
616.8-dc21 2003052904
ISSN 0065-1419
ISBN 978-3-7091-7220-9
Preface
The 12thInternational Symposiumon BrainEdema ongoing therapeutic trials. Aquaporins and the effects
and BrainTissueInjury washeldonNovember10-13, on volume homeostasis were discussed in several pa
2002in Hakone Japan. This volume isa compilation pers. Regeneration was another highlight of the sym
of the papers presented and discussed in the sympo posium. Some manuscripts were dealing with the re
sium.The advisory board haveedited the papers and generation of nerve tissuedamaged by edema-related
summarized their respectivesessions.The round table processesand the role of progenitor/stem cellson the
discussion on the third day, a resume of the scientific functional and structural recoveryofthe neural tissue.
essence of the symposium, is also recorded in this There wereseveral reports on the clinical trials on the
volumeforreadersto haveaquickand comprehensive therapy of intracranial cerebral hemorrhage and de
overviewofthecurrent status ofbrain edema research compressivecraniectomy.
and treatment. During the symposium, Hakone Best Presenta
The title of the symposium this time was changed tion Award was selected by a committee chaired by
slightly to "Brain Edema and Brain Tissue Injury", A. D. Mendelow and presented to the best six pre
as we wanted to emphasize the importance of inter sentations. The awardees are acknowledged in this
cellular and tissue mechanisms as well as intracel volume.
lular molecular mechanisms in the formation, treat Theadvisoryboardhasfeltthat promptpublication
ment and resolution of brain edema. Despite rapid ismost important to make thisvolumevaluable inthe
advances in diagnostic and therapeutic procedures, field of rapidly advancing neuroscience. We wish to
brain edema is still a major threat to patients' lives express our thanks to all authors who enable us to
in the neurological/neurosurgical ward. Since brain publish this volume approximately 6 months after
edema isamultifactorial processassociated withmost the symposium. We also express our gratitude to the
brain tissue injuries, the brain edema symposia have members ofthe secretariat for their assistance to have
provided a unique opportunity for the exchange of a successfulsymposium and forpromptpublication of
modern laboratory information with clinicians in thisvolume.
practice. The symposium consisted of platform ses The Thirteenth International Symposium on Brain
sions, poster sessionsand 7lectures on various topics Edema willbeheldinAnn Arbor,USA in2005under
relating to brain edema. The topicsof the symposium thechair ofJ.T. Hoff.
ranged from cutting-edge neuroimaging technology,
molecular medicine to new therapeutic strategies and T KuroiwaandEditors
Contents
Generalreview
Okeda, R.:
Conceptand pathogenesis of"hypoxic-ischemicencephalopathy" 3
Marmarou, A.:
Pathophysiology oftraumaticbrain edema:currentconcepts............................................... 7
Hojf, J. T, Xi, G.:
Brain edema from intracerebralhemorrhage................................................................ II
Shima, K :
Hydrostatic brain edema:basicmechanismsand clinicalaspect ............................................ 17
Hossmann, K-A.:
Non-invasiveimagingmethods forthe characterizationofthepathophysiologyofbrain ischemia......... 21
Klatzo,L:
Cecile&OskarVogt:The significanceoftheir contributionsinmodernneuroscience...................... 29
Imaging
v., s..
Fenstermacher, J.D., Knight,R. A.,Ewing,J.R., Nagaraja, T, Nagesh, Yee,J. Arniego, P. A.:
Estimating blood-brain barrier opening in a rat model of hemorrhagic transformation with PatIak
plots of Gd-DTPAcontrast-enhancedMRI............................................. ................... 35
Takizawa, 0.:
Recent developmentofMRimaging technique for theinvestigationofbrainfunction ..................... 39
Kurita,D., Haida, M., Shinohara, Y.:
Energy metabolismand cerebral blood flowduring cytotoxic brain edema induced by6-
aminonicotinamide.......................................................................................... 41
Nariai, T, Shimada, Y.,Ishiwata, K, Nagaoka, T, Shimada, J.,Kuroiwa, T, Ono,K-I,Hirakawa,K ,
Senda, M., Ohno, K :
PET neuroreceptorimaging aspredictorofseverecerebral ischemicinsult ................................. 45
s-e: c.
Hattori,N., Huang, Wu,H.-M.,Liao, W , Glenn, T Vespa, P. M., Phelps, M. E., Hovda, D. A.,
Bergsneider, M.:
Petinvestigationofpost-traumaticcerebral blood volume and blood flow........................ ......... 49
Nambu, K,Nariai, T, Terada, T:
Quantitativeevaluationofcerebral vascularpermeabilityusingmulti-slicedynamicCT................... 53
VIII Contents
Shiogai, T, Koshimura, M., Murata, Y, Nomura, H, Doi,A., Makino, M , Mizuno, T,Nakajima, K ,
Furuhata, H :
Acetazolamidevasoreactivityevaluatedbytranscranial harmonicperfusion imaging:relationshipwith
transcranial Dopplersonographyand dynamic CT ......................................................... 57
Kawaguchi, T :
Functional brainimagingofoptical topography............................................................ 63
Experimental global ischemia
c.
Kumura,E., Dohmen, Graf, R., Yoshimine, T, Heiss, W-D.:
Significant shrinkageofextracellularspace during global cerebralischemia:differencesingray andwhite
matterischemia.............................................................................................. 67
Lilt, L., Hirai, K, Basus, V J.,James, T L.:
NTPand PCrresponses to hypoxia byhypothermicandnormothermic respiring,superfused, neonatal
rat cerebrocorticalslices:an NMR spectroscopystudy at 14.1Tesla 71
Xiao,F, Arnold, T, Zhang, 8., Imtiaz, N,Khan, A., Alexander,J.8., Conrad, 8., Carden.D.:
Matrixmetalloproteinasesare not involved inearly brainedema formation after cardiacarrestin rats.... 75
u.
Konaka, K , Ueda, H , Nakano, M , J.-Y, Matsumoto, M , Sakoda,8., Yanagihara, T :
Regional N-acetyl-aspartateleveland immunohistochemicaldamageinthehippocampusaftertransient
forebrain ischemia ingerbils. ................................................................................ 79
Fukui,8., Nawashiro,H , Ookawara, T, Suzuki, K , Otani, N, Ooigawa,H , Shima, K :
Extracellularsuperoxidedismutasefollowingcerebralischemia inmice.................................... 83
Dohi,K , Ohtaki,H, Inn, R., Ikeda, Y, Shioda, H 8., Aruga, T:
Peroxynitriteandcaspase-3 expression after ischemiajreperfusioninmouse cardiacarrest model. ......... 87
Yin, L., Ohtaki, H, Nakamachi, T, Dohi, K ,Iwai, Y ,Funahashi,H, Makino, R., Shioda, 8.:
Expression oftumornecrosis factor a (TNFa)following transientcerebralischemia..................... .. 93
Ohtaki, H, Mori, 8., Nakamachi, T, Dohi, K, Yin, L.,Endo,8., Okada, Y, Shioda, 8.:
Evaluationofneuronalcelldeathafteranewglobal ischemia model ininfantmice........................ 97
Imaizumi, Y , Mizushima,H ,Dohi,K , Ohtaki, H ,Funahashi, H , Shioda,8.:
Hippocampal heme oxigenase-I ina murine cardiacarrest model .......................................... 101
Uchino,H, Ishii, N, Shibasaki, F:
CalcineurinandcyclophilinD are differential targets ofneuroprotection byimmunosuppressantsCsA
and FK506 inischemic brain damage....................................................................... 105
Katsura,K-I,Kurihara,1., Watanabe, M., Takahashi, K,Katayama, Y:
FK506attenuates the post-ischemicperturbation ofproteinkinases andtyrosine phosphorylationinthe
gerbilhippocampalCAl sectors............ ....... ................................. ......................... 113
Piuta, R.:
Blood-brainbarrierdysfunctionandamyloidprecursorproteinaccumulationinmicrovascular
compartmentfollowing ischemia-reperfusionbraininjury with l-yearsurvival............................. 117
Contents IX
«.
Dohi,K,Satoh, Ikeda, Y.,Ohtaki,H , Shioda, S, Aruga, T:
Neuroprotectiveeffectfrom ischemiaand direct freeradical scavenging activity ofChoto-san (kampo
medicine) 123
00000 0000000000000000.00000000000 00000 0000 000000 0.00. 00 00 0.00000.000 0 00 00 . 00 . 0.0 0. 00 • • 0 0. 0.0.0.00000
Experimental focal ischemia
u.,
Ito, Kuroiwa, T, Hanyu,S, Hakamata, Y,Kawakami,E., Nakano,I, Oyanagi, K:
Temporal profileofexperimentalischemicedema afterthresholdamountofinsult to induce infarction-
ultrastructure, gravimetryand Evans' blue extravasation 131
00 00 00 0 00 00 00 0 0.000• • 0.0 00000.0.0 0.00 0 00 00 0. 0 0000 00
Sakoh, M, Ohnishi, T, Ostergaard,L., Gjedde, A.:
Predictionoftissuesurvival after strokebased onchanges in the apparentdiffusion ofwater(cytotoxic
edema). 137
0 0• • 00 0. 0. 000 00 00 0 00000 000 0. 00 0 00 0 00 0 00 0. 00 0. 00 0000 0 00 00 00 00 0 00 0.0. 00.0 0.0. 000 000. 0. 0 00. 000 0 0000000000
Tanaka, Y, Kuroiwa, T, Miyasaka,N, Tanabe, F, Nagaoka, T, Ohno,K:
Recovery ofapparentdiffusioncoefficientafter embolic strokedoes not signifycomplete salvage ofpost-
ischemicneuronal tissue. 141
00 0• • 0• • 0 00 0• 0 0• 0 00 0• 0 • • • 0 0• • 0 00 ••00 0• 0 00 00 00 0 00 00 0 00 0 00 0 00 00 • • 00 0• 0 0• • • 0• • 00 0• 0 0• 00
Yamada, I, Kuroiwa, T, Endo, S, Miyasaka, N:
Temporalevolutionofapparentdiffusion coefficientand T2 value following transientfocal cerebral
ischemia ingerbils 147
0000000 0.000000 0 00000000 00000 0000 0000 0000 00000 00 00 0 . 0 00 0.0 0.00.0000.000.000 .0• • •••0• • 0.0. ..
Toyota, S, Graf,R; Valentino, M, Yoshimine, T, Heiss, W-Do:
Prediction ofmalignantinfarction:perifocal neurochemicalmonitoringfollowing prolonged MCA
occlusion incats. 153
0 00.00 0 0• 0• 000• 0• 0• • 0••0• 0• • 00 0• 0• 00 • 00 0• 00 0• 0• 0 0• 0• 0• 0• 0 0• 0 00 0• 0 00 0 00 00 00 00 00 • 00 0 0• 0 00 0• 0 0•
s;
Ishibashi, S, Kuroiwa, T,Endo, S , Okeda, Mizusawa, H:
Acomparisonoflong-termneurological symptomsafter two different focal ischemicmodels in
Mongoliangerbils 159
0000 0 00 0 00000• 0• 0 0• 0• 0 0 00 0• 0• 0 00 00 00 00 00 0• 0 00 00 00 0 00 0• 0• 0 0• 0 0• 00 0 0• 00 0• 0 00 00 00 0• 0 0• 0 00 ••00 •
Hua, Y., Wu,i., Keep,s.F, Hojf,Jo T, Xi, Go:
Thrombinexacerbatesbrainedema infocal cerebral ischemia 163
00 00 0 00 0• 0• 0 0• 0 0• 0• 0 0• 00 0• 0• 00 0• 0 00 00 00 00 00 0 00
Kano, T,Harada, T, Katayama, Y:
Infiltration oftissueplasminogenactivatorthroughcerebral vessels:evaluationusinga rat
thromboembolicstrokemodel. . 167
0 00 0• 0 00 0• 0 0• 00 0 00. 0 00 00 00 0• 0 00 00 00 0 00 0• 0• 0 • • 0 • •••••••••••••0 • 0 00 0• 0• • 00 • • 0 0•
Tabuchi, S, Uozumi, N, Ishii,S, Shimizu, Y, Watanabe, T, Shimizu, T:
Micedeficientincytosolic phospholipaseA2are lesssusceptible to cerebralischemia/reperfusioninjury .. 169
Mituhashi, T, Hatashita, S, Ogino, L:
Regionaldistributionofpotassiumandphosphorusinischemicbraintissue ofrats with X-ray
fluorescenceanalysis 173
0 0 0• 0 00000 00 00 0 • 0 00 0 0• 00 • • 0 00 0• 00 0• 0• 0 0••• 00 ••0 00 ••0 0• • 0 0 ••0 00 • • 00 ••0 0 00 00 0• 00 0 0• 0 00 0• 0 00
Kamada, H, Sato,K,Iwai, M, Ohta,K,Nagano, I, Shoji,M ,Abe,K:
Changesoffreecholesteroland neutrallipidsaftertransientfocal brainischemia inrats.. 177
0 • • 0••••00.000• • 0
Sailor,K A.,Dhodda, V. K,RaghavendraRao, V. L.,Dempsey,R.i.
Osteopontininfusion into normal adultrat brainfailsto increase cellproliferationindentategyrus and
subventricularzone 181
0 0 0• 0 00 . 00 00• 0• 0 ••0• 0 0• 00 • • • • • 0 •••0 • • • 00 0••00 0 • 0 0 00 • 0 0••0 0 • • • 0 0• 00 0 • 0 0••0 0• ••••0 • 0 0 • 0 00 0• 0
X Contents
Ohta,K ,Iwai, M , Sato, K, Omori, N ,Nagano, I. Shoji, M, Abe, K :
Dissociativeincrease ofoligodendrocyteprogenitorcellsbetween young and aged rats after transient
cerebralischemia 187
0 00 0 00 0 00 0 0 00 00 00 00 00 00 00 0 00 00 0 00 00 00 00 0 00 00 0 00 0 00 00 00 00 000 00 00 00 0 00 0 000000 00 0000000000 00000
Ohtaki,H, Takaki, Ao, Yin,L., Dohi, K, Nakamachi, T, Matsunaga, M, Horai, s., Asano,M ,
Iwakura, Y., Shioda, S:
Suppression ofoxidative stressafter transientfocal ischemia in interleukin-l knock out mice 191
0 00 0 0 0 00 0 00 0 00
Kamiya, T, Nito, C, Ueda, M, Kato,K,Amemiya, S, Terashi, Ao. Katayama, Y.:
Mild hypothermiaenhancesthe neuroprotectiveeffectsofa selectivethrombin inhibitorfollowing
transientfocal ischemia in rats 195
0....0 0....0....0....0 ......0 ..0....0 ..0 0..0......0" 0........0 00 ..0 00 0....0 0 0
Nito. C, Kamiya, T, Amemiya, S, Katoh, K, Katayama, Y.:
The neuroprotectiveeffectofafreeradical scavenger and mild hypothermiafollowing transientfocal
ischemia in rats 199
0 00 00 0 00 0 00 0 0 00 00 00 00 0 000 00 0 00 00 0 00 0 00 00 00 00 0 00 00 0 00 0 00 00 000 00 00 00 0 00 0 00 00000 0 00 0 0 0 0 00 0 00 0 0 00 0
Zausinger, S, Lumenta,DoB: Pruneau, Do, Schmid-Elsaesser,R; Plesnila,N, Baethmann,Ao:
Therapeuticalefficacyofa novel non-peptidebradykinin B receptorantagoniston brain edema
2
formation andischemic tissuedamageinfocal cerebralischemia 205
0 0 00 00 00 00 00 00 00 000 0 00 000 0 0000 0000 00 0 0 00 0 00
Yamada, M, Yuzawa,I, Fujii, K:
Iodoamphetamine(IMP) uptake inthe brainisincreasedafterexperimentalcerebralvenous
hypertensionin the rat 209
0 00 00 0 00 0 00 00 00 00 00 0 00 00 0 00 00 00 0 00 00 0 00 00 00 0 00 00 0 00 00 000 00 00 0 00 0 0 00000 0 00 0 0 00 0 00 0 0 00 0 00
Kimura,Ro, Nakase, H,Sakaki, T, Taoka, T, Tsuji, T.:
Vasogenic edemaandVEGFexpression inarat two-vein occlusion model 213
0000000000000 000000 0 0 00 00 0000000
Tomita,M; Tanahashi, N, Takeda, H. Takao, M , Tomita, Y., Amano, T .Fukuuchi, Y.:
Astroglial swellinginthe neuronal depolarizationensemble 219
0 000000 0 00 00 0000000 00 00000 0 0 0000 000000000000 0 000
Yamamoto,So, Matsumoto, Y., Suzuki, Y., Tsuboi, T, Terakawa, S, Ohashi, N, Umemura,K:
An Na"/H+exchangerinhibitorsuppressescellularswellingand neuronaldeath induced byglutamatein
culturedcortical neurons 223
00 0 0 00 00 0 00 00 00 00 00 0 00 00 00 0 00 00 00 0 00 00000 00000 00 00 00000 00 0 00 0 00 0 0000 00 0 00 0 00000 00 0 00
Hirai, K, Hayashi, T, Chan, PoH., Basus, V t..James, T L.,Lilt, L.:
Aktphosphorylationandcellsurvival afterhypoxia-inducedcytochromecreleaseinsuperfused respiring
neonatal rat cerebrocorticalslices 227
00 00 00 00 00 0 00 00 00 0 00 00 0 00 00 00000 00 0 00 00 00 00000 00 00 0 00 0 0 000 0 00 00 00 000 00 00 00 0
Tokumine, L, Sugahara,K, Kakinohana, 0., Marsala, M :
The spinal GDNFlevelisincreasedafter transientspinal cord ischemia inthe rat 231
00000000000000 000 00 000000
Clinical ischemia
Heiss, W-Do, Dohmen, C, Sobesky, L, Kracht,L., Bosche, B; Staub,F, Toyota, S , Valentino, M,
Graf, s..
IdentificationofmalignantbrainedemaafterhemisphericstrokebyPET-imaging andmicrodialysis 237
000 00
Igarashi,H, Hamamoto, M, Yamaguchi, H, Ookubo, S ,Nagashima, J; Nagayama,H,Amemiya, S,
Arii,K, Sakamaki,M ,Katayama, Y.:
Cerebralbloodflowindeximage asasimpleindicatorfor the fate ofacute ischemiclesion 241
00000000 000 00 0 00
Contents XI
DoM,K, Mochizuki, Y, Satoh,K,Jimbo, H, Hayashi,M , Toyoda, I.,Ikeda, Y,Abe, T ,Aruga, T:
Transientelevation ofserum Bilirubin (a heme oxygenase-I metabolite) levelinhemorrhagicstroke:
bilirubin isamarkerofoxidant stress .................................................... ................. .. 247
Sakurai, A., Kinoshita,K, Atsumi, T , Moriya, T , Utagawa, A., Hayashi, N :
Relation between brain oxygenmetabolismand temperaturegradient between brainand bladder......... 251
Experimental trauma
Vink, R., Young,A., Bennett, C. J., Hu, X , Connor, C. 0., Cernak, I.,Nimmo, A.J.:
Neuropeptide releaseinfluencesbrain edemaformation after diffusetraumaticbraininjury ............... 257
Amorini,A. M.,Dunbar,J. G., Marmarou,A.:
ModulationofAquaporin-4 water transport ina model ofTBI 261
Eriskat,J.,Fiirst, M ,Stoffel, M , Baethmann,A.:
Correlationoflesion volumeand brainswelling from afocal braintrauma 265
Otani, N , Nawashiro,H , Nomura,N, Fukui, S , Tsuzuki,N ,Ishihara, S , Shima,K:
A roleofglialfibrillaryacidicprotein inhippocampaldegeneration aftercerebral trauma or kainate-
induced seizure 267
McCarron,R. M ,Shohami,E., Panikashvili, D., Chen, Y, Golech, S ,Strasser, A., Mechoulam, R.,
Spatz, M :
Antioxidantpropertiesof thevasoactiveendocannabinoid,2-arachidonoylglycerol(2-AG)............... 271
Suzuki, R.,Fukai, N , Nagashijma, G.,Asai,J.-I., Itokawa, H , Nagai, M, Suzuki, T,Fujimoto, T:
Veryearlyexpression ofvascular endothelial growthfactorinbrain oedema tissueassociatedwith brain
contusion .................................................................................................... 277
Wang,J., Takeuchi, K, Ookawara,S:
Changesofperivascularmacrophagesin the processof brainedema induced bycold injury............... 281
Otani,N, Nawashiro,H, Tsuzuki, N ,Katoh, H, Miyazawa, T, Shima,K:
Mitogen-activated proteinkinasesphosphorylation inposttraumaticselectivevulnerabilityinrats........ 287
Kawai, N ,Kawanishi, M.,Nagao,S :
Treatmentofcold injury-induced brainedema witha nonspecificmatrixmetalloproteinaseinhibitor
MMI270inrats o. 291
0 0 . 0.0• ••••••••••••0• • • • 0••••••••0• • • • • • • • • • • ••• • •••••• •••••• ••• • 0••• • 0 0• • • 000000 00 0 00
Hishino,S, Inoue,K , Yokoyama, T ,Kobayashi,S, Asakura, T , Teramoto, A., Itohara,S :
Prionspreventbraindamageafterexperimentalbrain injury:a preliminary report. 297
0• • 0 • • • • • • • • • • • • • • • • • • • •
Fukui, S ,Signoretti,S , Dunbar,J. Go, Marmarou,A.:
The effect ofCyc1osporinAon brainedemaformation followingexperimentalcorticalcontusion......... 30I
Atsumi, T , Hoshino, S, Furukawa, T , Kobayashi,S , Asakura, T., Takahashi, M., Yamamoto, Y,
Teramoto,A.:
The glutamateAMPA receptor antagonist,YM872,attenuatesregionalcerebraledema and IgG
immunoreactivityfollowing experimental brain injuryin rats 305
0 00 . 00 • • 00 0.0• • 0 • • • ••• ••••••• • • • 0 .