Bone Metastasis and Molecular Mechanisms: Pathophysiology PDF
Preview Bone Metastasis and Molecular Mechanisms: Pathophysiology
Bone Metastasis and Molecular Mechanisms Cancer Metastasis - Biology and Treatment VOLUME 6 Series Editors Richard J. Ablin, Ph.D., Tnnapharma, Inc., Park Ridge, NJ, U.S.A. Wen G. Jiang, M.D., University ofW ales College of Medicine, Cardiff, u.K. Advisory Editorial Board Harold F. Dvorak, M.D. Phil Gold, M.D., Ph.D. Ian R. Hart, Ph.D. Hiroshi Kobayashi, M.D. Robert E. Mansel, M.S., FRCS. Marc Mareel, M.D., Ph.D. Titles published in this Series are: Volume I: Cancer Metastasis, Molecular and Cellular Mechanisms and Clinical Intervention. Editors: Wen G. Jiang and Robert E. Mansel. ISBN 0-7923-6395-7 Volume 2: Growth Factors and Receptors in Cancer Metastasis. Editors: Wen G. Jiang, Kunio Matsumoto and Toshikazu Nakamura. ISBN 0-7923-7141-0 Volume 3: Cancer Metastasis-Related Genes Editor: Danny R. Welch ISBN 1-4020-0522-9 Volume 4: Proteases and Thcir Inhibitors in Cancer Metastasis Editor: Jean-Michel Foidart and Ruth J. Muschel ISBN 1-4020-0923-2 Volume 5: Micrometastasis Editor: Klaus Pantel ISBN 1-4020-1155-5 Bone Metastasis and Molecular Mechanisms Pathophysiology Edited by Gurmit Singh Director ofR esearch, Juravinski Cancer Centre/ Professor of Pathology & Molecular Medicine, McMaster University, Hamilton, Ontario, Canada and William Orr Chair, Department ofP athology, University ofM anitoba, Winnipeg, Manitoba, Canada Springer Science+Business Media, B.V. A C.I.P. Catalogue record for this book is available from the Library of Congress. ISBN 978-90-481-6563-6 ISBN 978-1-4020-2036-0 (eBook) DOI 10.1007/978-1-4020-2036-0 Printed on acid-free paper All Rights Reserved © 2004 Springer Science+ Business Media Dordrecht Originally published by Kluwer Academic Publishers in 2004 Softcover reprint of the hardcover 1s t edition 2004 No part of this work may be reproduced, stored in a retrievaI system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilrning, recording or otherwise, without written permission from the Publisher, with the exception of any material supplied specifically for the purpose ofbeing entered and executed on a computer system, for exclusive use by the purchaser of the work. Dedicated to: Bone Metastasis Researchers and Cancer Patients. CONTENTS List of Contributors ............................................................. .ix Preface ............................................................................ xv Gurmit Singh Chapter 1 ............................................................................ 1 Models of Breast Cancer Metastasis to Bone: Characterization of a Clinically Relevant Model Belinda S. Parker, Bederich L. Eckhardt and Robin L. Anderson Chapter 2 .......................................................................... 19 Quantitation of Bone Metastasis in Experimental Systems Julie A. Sharp and Erik W. Thompson Chapter 3 .......................................................................... 31 Comparative Morphometric Study on Bone Remodeling in Human Specimens and in Experimental Models of Metastatic Bone Disease Snezana Vukmirovic-Popovic, Eric Seidlitz, F. William Orr and Gurmit Singh Chapter 4 ..........................................................................4 9 Clinical Modalities for the Diagnosis, Characterization and Detection of Bone Metastases Michael H. Weber, Jonathan C. Sharp, Thomas H. Hassard, Martin Reed, James A. Thliveris and F. William Orr Chapter 5 .......................................................................... 71 Metastasis in the Bone Marrow Microenviroment Paolo Bianco, Mara Riminucci and Pamela Gehron Robey vii Chapter 6 .......................................................................... 87 The Role of Tumor-Associated Macrophages in Metastasis Associated Osteolysis Nicholas. A. Athanasou Chapter 7 ........................................................................ 10 9 The Malignant Hierarchy in Multiple Myeloma: Relationships between Malignant Cells and Bone Disease Linda M. Pilarski, Tony Reiman, Patrick M. Pilarski, F. William Orr and Andrew R. Belch Chapter 8 ......................................................................... 139 Angiogenesis and Lymphangiogenesis in Metastatic Bone Disease: A Matter of Networking Gabri Van Der Pluijm, and Jereon Buijs Chapter 9 ........................................................................ 163 Prostate Cancer: Models for Developing Novel Therapeutic Approaches Shafaat A. Rabbani, Nicholas Shukeir and Andrew P. Mazar Chapter 10 ....................................................................... 187 Potential Therapeutic Targets for Bone Metastasis Sadmeet Singh and Gurmit Singh Chapter 11 .......................................................................2 11 OPG, RANK and RANKL in Bone Metastasis and Cancer Associated Osteolysis Paul J. Kostnuik Chapter 12 ....................................................................... 241 Role of Matrix Metalloproteinases in Bone Metastasis from Human Breast and Prostate Cancer Wilhelmina C.M Duivendoorden and Gurmit Singh Chapter 13 ....................................................................... 277 The Role of Bisphosphonates in Bone Metastasis Mary Mackenzie and Pierre Major INDEX ........................................................................... 303 VlIl CONTRIBUTORS EDITORS Gurmit Singh Director of Research Juravinski Cancer Centre Professor of Pathology and Molecular Medicine McMaster University Hamilton, Ontario, Canada William F. Orr Chair of Pathology Health Sciences Center University of Manitoba Winnipeg, Manitoba, Canada CONTRIBUTORS Robin L. Anderson Head, Cancer Biology Laboratory Peter MacCallum Cancer Institute East Melbourne, Victoria, Australia Nicholas A. Athanasou Departments of Surgery and Pathology Nuffield Department of Orthopaedic Surgery University of Oxford Oxford, UK ix Andrew Belch University of Alberta and Cross Cancer Institute Alberta, Canada Paolo Bianco Dipartmeento di Medicina Sperimentale e Patologia Universita "La Sapeinza" Parco Scientifico Biomedico San Raffaele Rome, Italy J eroen Buij s Department of Endocrinology Leiden University Medical Center Leiden, Netherlands Wilhelmina C.M Duivenvoorden Northwestern Ontario Regional Cancer Centre Thunder Bay, Ontario, Canada Bedrick L. Eckhardt Peter MacCallum Cancer Centre East Melbourne, Victoria, Australia Thomas H. Hassard Department of Community Health Science University of Manitoba Winnipeg, Manitoba, Canada Paul J. Kostenuik Research Scientist Amgen Inc. Thousand Oaks, California, USA Mary Mackenzie Medical Oncology Juravinski Cancer Centre Hamilton, Ontario, Canada Pierre P. Major Medical Oncology Juravinski Cancer Centre Hamilton, Ontario, Canada x Andrew P. Mazar Attenuon, LLC San Diego, California, USA Belinda S. Parker Peter MacCallum Cancer Center East Melbourne, Victoria, Australia Linda M. Pilarski University of Alberta and Cross Cancer Institute Alberta, Canada Patrick M. Pilarski University of Alberta and Cross Cancer Institute Alberta, Canada Shafaat A. Rabbani Departments of Physiology and Medicine Royal Victoria Hospital McGill University Health Centre Montreal, Quebec, Canada Martin Reed Department of Radiology Health Sciences Center Winnipeg, Manitoba, Canada Tony Reiman University of Alberta and Cross Cancer Institute Alberta, Canada Mara Riminucci Parco Scientifico Biomedico San Raffaele Rome Italy Departmento di Medicina Sperimentale Universita dell' Aquila L' Aquila, Italy xi
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