USMLE STEPS 2&3 wth is tornan-conmmercial usage by delete this fle immediatly! ‘BRAD CRAM RpEARESRRVEN PD AFA ‘ekannponano HOTON h KPpOBEIO Deca == grew By Melanie Maytin ph Loscalzo BLUEPRINTS IN CARDIOLOGY fe aCe BLUEPRINTS in CARDIOLOGY Editor Eric H. Awtry, MD, FACC ‘Asia Profesor of Medicine sna Urveniy Shu of Metin Director of Fducation, Section of Cadilegy os Medea! Caner, Dostio, Mascdrtts, Authors Arjun V. Gururaj, MD. “Teaching Fellow in Interal Medicine oman Universi Selo of Mine Flown lenighy elegy [Dwsion of Carselogy Tsim Metal Center Biotin, Minaachnoests Blackwell Publishing Melanie Maytin, MD ‘emg below e Mcene no Gaver Seed ot Mee Fell, Sone vitogy anos Medel Car Boon, Mamehacre Michael W. Tsang, MD “echng Reo in Med Too Unban Sead Tallow, Seton ol Cele Teen Mee) Center Tovon Masch Benoy |. Zachariah, MD, MRCP “acing alloy in ein Hen User Soo Neltce Gini Fel in cena Cnilgy Bono Matin Concer Heoson, Mase Faculty acvisor Joseph Loscalzo, MD, PhD Wade Picton or ine Tener Umer Short Nese (Gharmen,Bepedina of Modine Bowens Mowalenees © 2000 5 Blhckvel Science ‘Blackwell Publishing cernpenye Blockvell Publishing, Inc, 350 Main Suet, Malden, Messechuserts 02148-S018, USA Blacleell Science Led, Oxney Mend, Ostord OX2 URL, UK Plaloell Science Asia ry Ld $50 Swanton Servet, Carlton, Viewers 3053, Aner lackvell Verlag Gm, Kurfirsterdamm $2, 10707 Berlin, Clemany Allrights reserved. No part ofthis publiction nay be repreduc in any foun ot by ty elecuenic or mechanic rncane,iaeadang inlorsaton seoraye and retrieval sytem, without persesion in writing Irom Use publiher, azept by a reviewer who may quote brit pusages in a roviews MOO S4I2T ISHN: 0.612 9160087 ira uf Congress Catslegingin Pais Data Bluyrints in eandilogy /edion, Eric H. Avie autkers, Mae Maytin.. [etal sem CBlucprats sexes) ISBN 0-532-096287 (oh) 1 Heart Diwies—Oulines, lhl, et 2. Cardiclogy--Ouiny fa ee IDNLM _ 1. Hear Disezer Outlines. 2. Cardology—Ourines, WG 18-2 D658 2002] 1, Away, Ere 1 Naytin, Melanie, I. Hlvepris RS? 558 2002 20013 A eotalogee record for ths tiles avuble tothe British Library Acquisifons: Noney Daly Development: Angela Gagliano Production: Debra Lally Cover design: Hanaus Desigo Typescticr: SNP Bester Ijpeseter Led, Hong Kong rinted snd nd by Capital City Pres fa Verve, USA, Fer farter information on Rlacesell Publishing, vst cnr website swwichlaclellcences Notice: The indicarrs and dosages ofall drugs in this book have heen recommend! in the esedica Hrerarure and corfortn tn the practices of the peneral community. The, medications deseribed and treatment prescriptions suggested do not necessarily have specific approval bythe Food end Lirug Administration for use in the diseases and dasages for which they ste vecamuaended, The puckage insert for each drug should be consulted for use and Aosage as appraved hy the FDA. Recanse staslards for usage change, i is advisable 10 keep abreast of revised recommenclatiens, particully those cancerning new drugs w Preface Acknowledgments Reviewers Abbreviations Signs and Symptoms Important Cardiovasculer Formulas History and Physical Kxamination 1 Chest Pain 2 Dyspnea 3. Palpitations 4 Physical Examination of the Cardiovascular System Diagnostic Modalities 5 The Flectrocardiogram 6 Stress ‘Testing 7 Echocardiography 8 Cardiac Catheterization 9 Diagnostic Modalities for Archythmnias a 10 Other Invaging Modalities 4 TI Coronary Artery Disease st 11 Coronary Artery Disease—Pathophysiology 53 12 Dyslipidemia 37 13. Chronic Stable Angina 6 14 Unstable Angina ard Non-S'V Elevation Myocardial Infarction 15. ST Elevation Myocardial Infarction 16 Complications of Myocardial Infarction IV Heart Failure 81 17 Cardiovascular Hemodynamics 83 18 Mechanisms of Heart Failure 87 19 Clinical Manifestations and Treatment of Heart Failure 0 20. Myocarditis o 21 "The Cardiomyopathies 9 Vi Archythmias 105 22 Mechanisms of Arrhythmogenesis, 107 23° Tachyarthythmias ur 24 Bradyarhythmiias (Bradycardia and Heart Block) 117 25. Syncope 122 26 Sudden Cardiac Death 127 27° Pacemakers and Implantable Cardioverter Defibrillators BI VI Valvular Heart Disease 135 28 Rheumatic Fever BF vit vor Ix ‘Blueprints in Cardiology | vik 29 Disorders of the Aortic Valve 30 Disorders of the Mitral Va 31 Infective Endocarditis 32 Prosthetic Heart Valves Pericardial Diseases 33. Pericarditis 34 Cardise Tamponade 35. Constrietive Pericarditis ‘Vascular Di 36 Llypertension 37 Peripheral Arterial Disorders 38 Diseases of the Aorta 39 Carotid Arterial Disease 40 Deep Venous Thrombosis and Pulmonary Embolie Disease 41 Pulmonary Ilypertension Congenital Heart Disease 42 € diac Shunts genital C 43. Cyanotie Congenital Heart Disease Other 44 Pregnancy and Cardiovascular Disease 45° Traumatic Heart Dis 46 Cardice Tumors Questions Answers Index M1 145 150 157 161 163 Preface “Tacky malcal mainces are fased with the seemingly insurrwountable ash of tering an ever-expanding boxy of knosfedge. Not only is the silent exacted £2 ‘understand the pathophysiologial hess uf discasc, hur al to recognize the diverse inthe clinial setting, letermine che approyste tests with which to fully ewabuste the disease, inverpret she rests of these rests, ard apply all ofthis infurmasem «© the development of an appropriate treasment plan. ‘These sills are then testes both ar the hedside snd in a series of USMLE. exarinations. While no stident car be expected! te know every aspect of maslicine, certain fundamental principles must be identified and learned, This can be difcule given the corrent state of inforragtion awverlaad. Tu we specialty ic this trer than in the field of cardiology: The part covers de vast aray of mercasingly more comples diayrastic modalities and the development of innumerable phansavslegieal und non-pharuiacolugical Userepies. In iion, a veritable tidal wave of clinical rials has been performed, aimee! ar derermining the appropnte rs of these diggnostie and therapeutic options. ln this new addition to the Elusprint series, we have attempted to cover the core competencies in cardiology. We have discussed those skills that are essential 1 success in clinieakroterions Gnehuding key eariaesyrmproms ane! physical find ing, 8 well asthe interpretation of cerdiae tests), and have cewered a broad array cf cardiac diseeders that consistntly appear on the hoard examinations. Alchough memorization of specific facts isan essential component ofthe leemning process, ‘ve serongly fe thar arrue understanding of disease requires knowledge uf disease process, Throughout the text, we briefly review the pathophysiology of eardiac tiseases and use this tev.ew a6 a guide to understanding the clinieal presentation and treaement of these diseases We hope thar yom find Blueprints ie Coils informative and useful. We weloome feedhack and sipgestians yon may have abour this beok or any in the lupin: cries. Send ta Bhebdeclscicem. der have witnessed the introduction of a rie IL Awery Aajun Ve Gururg ‘Melanie Mayan Michael W. Lang. Benoy J. Zachariah Joseph Losialeo eee imam aan Acknowledgments Th my wife, Sardhya Wahi-Curara, MD, MPHL, and mp parents for all their support AG. Tomy wife Nina and daughter Reshini for their support ard patience while T was working on this hook, 2, “i [LALA. for keeping me on track and for undersanding when T wasn’. To 1. for affoning me the opportunity. Te DL. tel MTS, for being consumeaate mentors and wonderful fiends, and for always pushing, mie to “rise the bar” AM, T would like to thank che students and residents uf Boston Medies! Center, whose cothusiasm for leaming wake teaching so enjoyable and projects such this so rewarding, Te my co-audhers un editor: char you for your insight, expertise, and eouuniuient (© dis project. Fnally, [would like eo e'ank any wife Kyle an children Jake, Nicholas, and Zachary for their endless support, patience, and encounigement, iA — = seuss Reviewers Brian L. Dunfee “Temple University Chess of 202 Phitadetgh Deborah Lam Nexthwestern University Chess of 2002 Evanston, Minos Saced Sadeghi, MD PCYS resident epariment of Internal Mectcn Keck School af Medicine at University of Southern Califcenia University of Southern California Medical Center Los Angeles, Califounia . Pennsphania Peadnys Mitron MD. Toternal Medicine PGYL ‘Thomas Jefferson Universicy Hospital Dhiba, Penasyhes