Blue Biotechnology: From Gene to Bioactive Product PDF
Preview Blue Biotechnology: From Gene to Bioactive Product
Progress in Molecular and Subcellular Biology Marine Molecular Biotechnology Werner E.G. Müller Heinz C. Schröder Xiaohong Wang Editors Blue Biotechnology From Gene to Bioactive Product Progress in Molecular and Subcellular Biology Marine Molecular Biotechnology Volume 55 Series editor Werner E.G. Müller, Mainz, Germany More information about this series at http://www.springer.com/series/7234 ü ö Werner E.G. M ller Heinz C. Schr der (cid:129) Xiaohong Wang Editors Blue Biotechnology From Gene to Bioactive Product 123 Editors WernerE.G.Müller Xiaohong Wang ERCAdvancedInvestigatorGroup,Institute ERCAdvancedInvestigatorGroup,Institute forPhysiological Chemistry forPhysiological Chemistry University Medical Center ofthe Johannes University Medical Center ofthe Johannes Gutenberg-University Mainz Gutenberg-University Mainz Mainz Mainz Germany Germany Heinz C.Schröder ERCAdvancedInvestigatorGroup,Institute forPhysiological Chemistry University Medical Center ofthe Johannes Gutenberg-University Mainz Mainz Germany ISSN 0079-6484 ISSN 2197-8484 (electronic) Progressin Molecular andSubcellular Biology ISSN 1611-6119 Marine Molecular Biotechnology ISBN978-3-319-51282-2 ISBN978-3-319-51284-6 (eBook) DOI 10.1007/978-3-319-51284-6 LibraryofCongressControlNumber:2016961268 ©SpringerInternationalPublishingAG2017 Thisworkissubjecttocopyright.AllrightsarereservedbythePublisher,whetherthewholeorpart of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission orinformationstorageandretrieval,electronicadaptation,computersoftware,orbysimilarordissimilar methodologynowknownorhereafterdeveloped. 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Printedonacid-freepaper ThisSpringerimprintispublishedbySpringerNature TheregisteredcompanyisSpringerInternationalPublishingAG Theregisteredcompanyaddressis:Gewerbestrasse11,6330Cham,Switzerland Preface Marineinvertebrateslikespongesandsponge-associatedmicroorganismsaresome of the richest sources of novel bioactive molecules and lead compounds for ther- apeutical and biotechnological applications. However, the sustainable exploitation of marine natural products is limited due to the supply problem. The only likely way to tackle this problem is to isolate and express the genes encoding the enzymes/proteins involved in biosynthesis of these products to obtain the active moleculesinsufficientamounts.Theaimofthisbookistodescribenewapproaches combining the present knowledge in marine genomics and advanced natural products chemistry for the sustainable production of novel secondary metabolites (lead compounds), as well as pharmacologically active peptides/proteins, with antimicrobial, neuroprotective, anti-osteoporotic, anti-protozoan/anti-plasmodial, anti-ageing and immune-modulating activities, using molecular-biology-based approaches and advanced chemical techniques, to obtain and to select candidate compounds for pre-clinical and clinical studies. The authors of this book include European or worldwide leaders in marine genomics and marine natural product chemistry/structure elucidation, as well as leading researchers from high-tech enterprises with special interest in biotechnology and bringing marine biotechnol- ogy products to the market. This book also comprises chapters describing the discovery and sustainable exploitation of molecules from hitherto unexploited extreme marine environments, advanced biosynthetic prediction techniques and methodsincomputer-aideddrugdiscovery,combinatorialbiosynthesismethods,as wellasstrategiesindrugdiscoveryanddevelopmentofmarine-derivedcompounds of biomedical and biotechnological interest. This book also summarizes main results of the European Union Framework Programme FP7 project “BlueGenics— Fromgenetobioactiveproduct:Exploitingmarinegenomicsforaninnovativeand sustainable European blue biotechnology industry” (project No. 311848; 2012– 2016); Fig. 1. Our intention is to demonstrate that the application of innovative v vi Preface Fig.1 GroupphotooftheEuropeanUnionFP7project“BlueGenics”teamduringthesummer school2016inRovinj,Croatia molecular biological approaches is the only way to sustainably exploit the enor- mous economic potential of the marine molecular biodiversity—for the future of blue biotechnology industry and human benefit. Mainz, Germany Werner E.G. Müller Heinz C. Schröder Xiaohong Wang Contents 35 Years of Marine Natural Product Research in Sweden: Cool Molecules and Models from Cold Waters.. ..... .... 1 Lars Bohlin, Paco Cárdenas, Anders Backlund and Ulf Göransson Major Antimicrobial Representatives from Marine Sponges and/or Their Associated Bacteria ... .... .... .... ..... .... 35 Fei He, Linh H. Mai, Johan Gardères, Amjad Hussain, Vesna Erakovic Haber and Marie-Lise Bourguet-Kondracki Discovery and Development of Novel Drugs.. .... .... .... ..... .... 91 Vesna Erakovic Haber and Radan Spaventi Computer-Aided Drug Discovery from Marine Compounds: Identification of the Three-Dimensional Structural Features Responsible for Antimalarial Activity .. ..... .... 105 CaterinaFattorusso,FrancescaRondinelli,MarcoPersico,NausicaaOrteca and Antonio Di Dato Bluegenics: Bioactive Natural Products of Medicinal Relevance and Approaches to Their Diversification.... .... ..... .... 159 Joseph S. Zarins-Tutt, Emily R. Abraham, Christopher S. Bailey and Rebecca J.M. Goss New Target Sites for Treatment of Osteoporosis .. .... .... ..... .... 187 Werner E.G. Müller, Xiaohong Wang and Heinz C. Schröder Biocalcite and Carbonic Acid Activators. .... .... .... .... ..... .... 221 Xiaohong Wang, Meik Neufurth, Emad Tolba, Shunfeng Wang, Heinz C. Schröder and Werner E.G. Müller vii viii Contents Electrospinning of Bioactive Wound-Healing Nets. .... .... ..... .... 259 Heinz C. Schröder, Emad Tolba, Bärbel Diehl-Seifert, Xiaohong Wang and Werner E.G. Müller Entotheonella Bacteria as Source of Sponge-Derived Natural Products: Opportunities for Biotechnological Production ... ..... .... 291 Agneya Bhushan, Eike E. Peters and Jörn Piel Contributors EmilyR.Abraham SchoolofChemistry,UniversityofStAndrews,StAndrews, Scotland, UK Anders Backlund DivisionofPharmacognosy,DepartmentofMedicinalChemistry, Biomedical Center, Uppsala University, Uppsala, Sweden Christopher S. Bailey School of Chemistry, University of St Andrews, St Andrews, Scotland, UK Agneya Bhushan Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, Zurich, Switzerland Lars Bohlin Division of Pharmacognosy, Department of Medicinal Chemistry, Biomedical Center, Uppsala University, Uppsala, Sweden Marie-Lise Bourguet-Kondracki Laboratoire Molécules de Communication et Adaptation des Micro-organismes, UMR 7245 MNHN-CNRS, Muséum National d’Histoire Naturelle, Paris, France PacoCárdenas DivisionofPharmacognosy,DepartmentofMedicinalChemistry, Biomedical Center, Uppsala University, Uppsala, Sweden Antonio Di Dato Department of Pharmacy, University of Napoli “Federico II”, Naples, Italy Bärbel Diehl-Seifert ERC Advanced Investigator Group, Institute for Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Mainz, Germany; NanotecMARIN GmbH, Mainz, Germany Vesna Erakovic Haber Fidelta d.o.o., Zagreb, Croatia Caterina Fattorusso Department of Pharmacy, University of Napoli “Federico II”, Naples, Italy ix
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