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Blood and Circulatory Disorders Sourcebook: Basic Consumer Health Information About Blood and circulatory System disorders, Such as Anemia, Leukemia, Lynphona, ... Thombophil, Third Edition PDF

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Health Reference Series ___________ _____________________________________________________________________________________________________________________ ___________ Omnigraphics’ Health Reference Series ______________________ _____________________________________________________________________________________________________________________ ____________J___u___d___d____________ _____________________________________________________________________________________________________________________ ______________________ ___________________________________________T___h___i__r___d___ _E____d___i__t_i__o___n____________________________________________ Helping the Layperson Understand, Manage, ______________________ _____________________________________________________________________________________________________________________ ___________ ________ ______________ _____________________________________________________________________________________________________________________ and Avoid Serious Illness ________C______________ _____________________________________________________________________________________________________________________ ______________________ _____________________________________________________________________________________________________________________ ___________ Omnigraphics’ Health Reference Series is designed for the general reader ________i______________ _____________________________________________________________________________________________________________________ seeking guidance on how to avoid serious illness by following preventive ___S_________r_____________________ ______________________________B_________l____o_______o_______d_______ ____a_______n_______d________ ___________________________ ___________ _____________________________________________________________________________________________________________________ ____c_______ wlifheost yhlaess raencde irveecdo gan diziainggn oesairsl yo wf aa rsneirniogu ssig dniss.e Iats ael soor sduipsoprodretsr tahse w laeyllp aesr stohne ____o____________u____________________________ __________________________________________________________________________________________________________________________________________________________________________________________________________________________________________ ___________ ftaom ciolyp em wemithb ethr eo ril lnnoenssp. rEoafecshs ivoonlualm cea rieng tihveer swerhieos mdeuaslts lceoarmnp troe hceanres ivaenldy ______u__________________la__________________B________________________ ______________________________________________________________________________C________________________i____________r__________________c__________________u________________________l____________a_____________________t_______________o_____________________r__________________y_____________________ _____________________________________________________________________ wpuitbhl iac aptiaorntisc uislsaur eadr ebay othf em Neadtiicoanl aclo Inncsetirtnu taens do fc Honetaaltinh sa nmda toetrhiaelr faoguenndc ieins ______r__________________to__________________lo________________________ __________________________________________________________________________________________________________________________________________________________________________________________________________________________________________ and associations. Nowhere else can general readers find this information ____C____________r____________o________________ ________________________________________________________________D__________________i________s____________o______________r__________d______________e____________r____________s______________________________________________________________________ ___________ conveniently collected, coordinated, and indexed in book form. _______d____ _____________________________________________________________________________________________________________________ ___e_________y_____________________ _____________________________________________________________________________________________________________________ ________ ______ ________ _____________________________________________________________________________________________________________________ Blood and Circulatory Disorders Sourcebook, ___B_________D_________a____________ _____________________________________________________________________________________________________________________ Third Edition _______o_____________________is_____________________nd____________________________ ____________________________________________________________S_____________________o________________________u________________________r________________________C________________________e________________________B________________________o________________________o________________________k______________________________________________________________________________ Blood plays many important roles in the human body. It carries oxygen ___o_________o_____________________ _____________________________________________________________________________________________________________________ and nutrients to the body’s cells, helps fight infection, and works to heal ________________r____________________________ __________________________________________________________________________________________________________________________________________________________________________________________________________________________________________ _k__________ wounds. When a disorder inhibits its ability to meet the body’s needs or ________d______________ _________________________________________________________________________________________________________________ ___ prevents blood from flowing or coagulating properly, a myriad of problems ______________________ _____________________________________________________________________________________________________________________ ________e______________ ________________________________________________________■_____________________________________________________________ caa qnu raerstuerlt m. Aicllcioonrd dinega tthos t pheer N yaetaior nina lt Hhee aUrnt iLtuedn gS atantde sB—loaopdp Irnosxtiimtuattee,l ny enairnley ____________________r___________________________________ __________________________________________________________________________________________________________________________________________________________________________________________________________________________________________ percent of all U.S. deaths—are attributable to blood diseases. ____________s_____________________ _____________________________________________________________________________________________________________________ ______________________ __________B__a___s_i__c__ _C__o__n___s__u__m___e___r_ __H___e__a__l_t__h__ _I__n__f_o__r__m____a__t__i_o__n___ _a__b___o__u__t__ _B__l_o___o__d__ __a__n___d__ ________ Blood and Circulatory Disorders Sourcebook, Third Edition offers facts _________________________________ _____________________________________________________________________________________________________________________ about blood function and composition, the maintenance of a healthy cir- ____________H________e____al____t____h____________ ____________C______i__r____c____u____l____a____t__o______r__y____ __S______y__s____t__e____m________ __D______i__s____o____r____d____e____r____s____,__ __S____u____c____h______ __a____s____ __A____n______e____m______i__a______,__ __L____e____u______k____e____m______i____a____,__ __________ culatory system, and the types of concerns that arise when processes go ______________________ _______L_y__m____p__h__o__m____a__,_ _R___h__ _D___i_s__e__a__s__e__,_ _H___e__m___o__p__h___i_l_i_a___,_ _T__h__r__o__m____b__o__p__h___i_l_i_a___,_ _O___t_h__e__r__ _____ adwisroyr. dIet rdsi,s bculesesdesin tgh ed idsoiargdneorss,i sa anndd c itrrceualtamtoernyt doifs omradneyr sc, oinmcmluodnin bgl oanoedm ceiall, ____________R______e______Sf______eer______rie______en______sc______e____________ ______________B____l__e____e______d____i__n______g____ __a______n____d______ __C____l__o______t__t__i____n____g____ __D______e____fi______c____i__e____n______c____i__e____s____,__ __a____n______d____ ____A____r____t__e____r____y____,__ __V____a______s__c____u______l__a____r____,__ __________ ______________________ _______a__n___d__ _V__e__n___o__u__s__ _D___i__s_e__a___s__e__s_,_ __I_n__c__l__u__d___i_n__g___ _F__a__c__t_s__ _a___b__o__u___t_ _B___l_o__o__d___ _T__y__p__e__s__,_ _____ hthermomocbhorpohmialitao, saist,h leeruokseclmeriao,s ilsy,m bplohoomd ap, rhesesmuorep hirilrieag, uhlyaprietirecso,a cgourlaotnioanry, ________3____r____d ____E____d____it____io____n________ ____________B______l__o____o____d______ __D______o____n______a____t__i____o____n____,__ __B______o____n____e______ __M______a____r____r____o____w______ __a______n____d______ __S____t__e____m________ __C____e____l__l____ __T__r____a______n____s____p____l__a______n____t__s____,__ __________ ___________ artery and heart disease, and peripheral vascular disease. Blood donation, ____________________________________________ ____________________________T____e____s____t__s____ __a______n____d____ ____M______e____d____i____c____a____t____i__o____n______s__,__ ____a____n______d____ __T____i__p______s__ ____f__o____r____ __M______a______i__n______t__a______i__n____i____n____g____ __________________________ cord blood banking, blood transfusions, and bone marrow and stem cell _________________________________ __________________________________________ C__i__r__c__u__l_a___t_o__r__y__ _H___e__a___l_t_h___________________________________________ transplants are also discussed. The book concludes with a glossary of related ______________________ _____________________________________________________________________________________________________________________ ___________ terms and a list of resources for further help and information. ______________________ _____________________________________________________________________________________________________________________ ______________________ ___________A__l_o___n__g__ _w___i__t_h__ __a__ _G___l_o__s__s__a__r__y__ _o___f_ _R___e__l_a__t__e__d__ _T__e__r__m____s_ _a___n__d___ _a___ _L__i_s__t_ _o__f__ _________ _____O_____m__________n_____ig_____ra_____p_____h_____ic_____s_____ ______________________________R______e____s____o____u____r____c____e____s____ __f__o____r____ __A______d____d______i__t____i__o____n______a____l__ __H______e______l__p____ __a______n____d______ __I__n______f__o____r____m______a______t__i____o____n________________________________ ___________ _____________________________________________________________________________________________________________________ ISBN 978-0-7808-1081-5 _____________________________________________________________________________________________________________________ _____________________________________________________________________________________________________________________ _____________________________________________________________________________________________________________________ __________________________________________________E___d__i__t_e__d__ __b__y__ _________________________________________________ _____________________________________________________________________________________________________________________ P.O. Box 31-1640 Sandra J. Judd Detroit, MI 48231 Phone: 800-234-1340 Fax: 800-875-1340 www.omnigraphics.com Job Name:15007 Date:10-04-15 PDF Page:15007cbc.p1.pdf Color: Black PANTONE 186 C __________________________________________________________________________________________________________________________________________ __________________________________________________________________________________________________________________________________________ __________________________________________________________________________________________________________________________________________ __________________________________________________________________________________________________________________________________________ __________________________________________________________________________________________________________________________________________ __________________________________________________________________________________________________________________________________________ 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_E__d___i_t_i__o__n_________________________________________________________ __________________________________________________________________________________________________________________________________________ __________________________________________________________________________________________________________________________________________ __________________________________________________________________________________________________________________________________________ __________________________________________________________________________________________________________________________________________ Blood and __________________________________________________________________________________________________________________________________________ __________________________________________________________________________________________________________________________________________ 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_________________________________B__a__s_i_c__ _C__o_n__s_u__m___e__r_ _H__e_a__l_t_h__ _I_n__f_o_r__m___a_t_i_o__n__ _a__b_o__u__t_ _B__l_o__o_d__ _a__n__d__ _____________________________ _________________________________C_i_r__c_u__l_a_t_o__r_y__ _S_y__s_t_e_m___ _D__i_s_o__r_d__e_r_s_,_ _S_u__c_h__ _a__s_ _A_n__e__m__i_a__,_ _L_e_u__k__e_m___i_a__,_ ____________________________ __________________________________________________________________________________________________________________________________________ ________________________________L_y__m___p__h__o_m___a__,_ _R__h__ _D__i_s__e_a__s_e__,_ _H__e__m___o_p__h__i_l_i_a__,_ _T__h__r_o__m___b__o_p__h__i_l_i_a__,_ ____________________________ __________________________________________________________________________________________________________________________________________ _________________________________O___t_h__e_r_ _B__l_e__e_d__i_n__g__ a__n__d__ _C__l_o__t_t_i_n__g_ _D___e_fi__c_i_e__n__c_i_e__s_,_ _a_n__d__ _A__r_t__e_r_y__,_ _____________________________ __________________________________________________________________________________________________________________________________________ Vascular, and Venous Diseases, Including Facts about __________________________________________________________________________________________________________________________________________ _________________________________B__l_o_o__d__ _T_y__p__e_s_,_ _B__l_o__o__d__ D___o_n__a__t_i_o__n__,_ _B__o_n__e__ _M__a__r__r_o__w__ _a__n__d__ _S_t_e__m__ _____________________________ __________________________________________________________________________________________________________________________________________ __________________________________C__e_l_l_ _T_r__a_n__s__p_l_a__n__t_s__, _T__e_s_t_s__ _a_n__d__ _M___e_d__i_c__a__t_i_o_n__s__, _a__n__d__ _T_i_p__s__ f_o__r_ ______________________________ __________________________________________________________________________________________________________________________________________ ________________________________________________M___a__i_n__t_a__i_n__i_n__g_ _C__i_r_c__u__l_a_t__o_r__y_ _H___e_a__l_t_h______________________________________________ __________________________________________________________________________________________________________________________________________ __________________________________________________________________________________________________________________________________________ __________________________________A__l_o_n__g__ _w__i_t_h__ _a__ _G__l_o__s_s_a__r__y_ _o__f_ _R_e__l_a__t_e_d__ _T__e_r_m___s_ _a__n__d__ _a__ _L_i_s__t_ o__f_ ______________________________ _____________________________________R__e__s_o__u__r_c_e__s_ _f_o__r_ _A__d__d__i_t_i_o__n__a_l_ _H___e_l_p__ _a__n_d__ _I_n__f_o__r_m___a__t_i_o__n___________________________________ __________________________________________________________________________________________________________________________________________ __________________________________________________________________________________________________________________________________________ __________________________________________________________________________________________________________________________________________ _________________________________________________________________E_d__i_t_e__d__ b__y______________________________________________________________ ___________________________________________________________S__a__n__d__r__a__ _J_._ _J_u__d___d_________________________________________________________ __________________________________________________________________________________________________________________________________________ __________________________________________________________________________________________________________________________________________ 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__________________________________________________________________________________________________________________________________________ __________________________________________________________________________________________________________________________________________ ____________________________________________________P_._O__. _B_o__x_ _3_1_-_1_6_4__0_, _D__e_t_r_o_i_t_, _M___I_ 4__8_2_3_1_________________________________________________ __________________________________________________________________________________________________________________________________________ __________________________________________________________________________________________________________________________________________ __________________________________________________________________________________________________________________________________________ __________________________________________________________________________________________________________________________________________ __________________________________________________________________________________________________________________________________________ __________________________________________________________________________________________________________________________________________ __________________________________________________________________________________________________________________________________________ Bibliographic Note Because this page cannot legibly accommodate all the copyright notices, the Bibliographic Note portion of the Preface constitutes an extension of the copyright notice. Edited by Sandra J. Judd Health Reference Series Karen Bellenir, Managing Editor David A. Cooke, MD, FACP, Medical Consultant Elizabeth Collins, Research and Permissions Coordinator Cherry Edwards, Permissions Assistant EdIndex, Services for Publishers, Indexers * * * Omnigraphics, Inc. Matthew P. Barbour, Senior Vice President Kevin M. Hayes, Operations Manager * * * Peter E. Ruffner, Publisher Copyright © 2010 Omnigraphics, Inc. ISBN 978-0-7808-1081-5 Library of Congress Cataloging-in-Publication Data Blood and circulatory disorders sourcebook : basic consumer health information about blood and circulatory system disorders, such as anemia, leukemia, lymphoma, Rh disease, hemophilia, thrombophilia, other bleeding and clotting deficiencies, and artery, vascular, and venous diseases, including facts about blood types, blood donation, bone marrow and stem cell transplants, tests and medications, and tips for maintaining circulatory health; along with a glossary of related terms and a list of resources for additional help and information / edited by Sandra J. Judd. -- 3rd ed. p. cm. Includes bibliographical references and index. ISBN 978-0-7808-1081-5 (hardcover : alk. paper) 1. Blood--Diseases--Popular works. 2. Blood-vessels--Diseases--Popular works. I. Judd, Sandra J. RC636.B556 2010 616.1'5--dc22 2010013182 Electronic or mechanical reproduction, including photography, recording, or any other infor- mation storage and retrieval system for the purpose of resale is strictly prohibited without permission in writing from the publisher. The information in this publication was compiled from the sources cited and from other sources considered reliable. While every possible effort has been made to ensure reliability, the publisher will not assume liability for damages caused by inaccuracies in the data, and makes no warranty, express or implied, on the accuracy of the information contained herein. This book is printed on acid-free paper meeting the ANSI Z39.48 Standard. The infinity symbol that appears above indicates that the paper in this book meets that standard. Printed in the United States Table of Contents Visit www.healthreferenceseries.com to view A Contents Guide to the Health Reference Series, a listing of more than 15,000 topics and the volumes in which they are covered. Preface............................................................................................xi Part I: Understanding Blood and the Circulatory System Chapter 1—Blood Function and Composition...............................3 Chapter 2—Blood Types...............................................................15 Section 2.1—Introduction to Blood Types...........16 Section 2.2—Blood Types in the United States..................................19 Chapter 3—Donating and Preserving Blood...............................21 Section 3.1—Frequently Asked Questions about Blood Donation.....................22 Section 3.2—Tips for a Good Donation Experience......................................24 Section 3.3—Apheresis.........................................26 Section 3.4—Cord Blood Banking........................28 Chapter 4—Maintaining a Healthy Circulatory System............31 Chapter 5—How Aging Affects the Heart and Blood Vessels......................................................37 v Part II: Diagnosing and Treating Blood and Circulatory Disorders Chapter 6—Blood Tests..............................................................45 Section 6.1—Blood Typing.................................46 Section 6.2—Complete Blood Count ................50 Section 6.3—Fibrinogen Test ............................54 Section 6.4—Reticulocyte Count ......................57 Chapter 7—Bone Marrow Tests.................................................61 Chapter 8—Bleeding and Clotting Tests...................................65 Section 8.1—Bleeding Time...............................66 Section 8.2—Partial Thromboplastin Time......68 Chapter 9—Tests Used in the Assessment of Vascular Disease.....................................................71 Chapter 10—Commonly Used Medications for Cardiovascular Health...........................................77 Section 10.1—Facts about Using Aspirin.........78 Section 10.2—Anticoagulants and Antiplatelet Agents....................81 Section 10.3—Using Coumadin Safely.............84 Chapter 11—Commonly Used Medications for Anemia.............91 Section 11.1—Iron Supplements.......................92 Section 11.2—Erythropoiesis-Stimulating Agents.........................................95 Chapter 12—Blood Transfusion...................................................99 Chapter 13—Bone Marrow and Stem Cell Transplants...........107 Chapter 14—Chelation Therapy: A Controversial Treatment Approach.............................................117 Part III: Blood Disorders Chapter 15—Anemia..................................................................127 Section 15.1—Anemia: An Overview...............128 Section 15.2—Anemia of Chronic Disease......135 Section 15.3—Aplastic Anemia.......................138 vi Section 15.4—Fanconi Anemia........................145 Section 15.5—Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency..................................154 Section 15.6—Hemoglobin C Disease.............157 Section 15.7—Hemoglobin E Disease.............159 Section 15.8—Iron-Deficiency Anemia............162 Section 15.9—Pernicious (Megaloblastic) Anemia......................................165 Section 15.10—Sickle Cell Disease...................167 Section 15.11—Spherocytosis............................173 Section 15.12—Thalassemia.............................176 Chapter 16—Hemochromatosis ................................................181 Chapter 17—Leukemia...............................................................187 Section 17.1—Acute Lymphocytic Leukemia..................................188 Section 17.2—Chronic Lymphocytic Leukemia..................................196 Section 17.3—Acute Myelogenous Leukemia..................................203 Section 17.4—Chronic Myelogenous Leukemia..................................212 Section 17.5—Hairy Cell Leukemia................218 Chapter 18—Lymphoma.............................................................225 Section 18.1—Hodgkin Lymphoma.................226 Section 18.2—Non-Hodgkin Lymphoma.........233 Section 18.3—Waldenström Macroglobulinemia...................244 Chapter 19—Myeloproliferative Disorders................................249 Section 19.1—Idiopathic Myelofibrosis...........250 Section 19.2—Myelodysplastic Syndrome..................................256 Section 19.3—Polycythemia Vera....................260 Section 19.4—Thrombocythemia and Thrombocytosis.........................267 vii Chapter 20—Plasma Cell Disorders..........................................277 Section 20.1—Amyloidosis...............................278 Section 20.2—Cryoglobulinemia.....................282 Section 20.3—Monoclonal Gammopathy of Undetermined Significance.....286 Section 20.4—Multiple Myeloma....................287 Chapter 21—Rh Disease.............................................................291 Chapter 22—White Blood Cell Disorders..................................295 Section 22.1—Hypereosinophilic Syndrome....296 Section 22.2—Histiocytosis.............................300 Section 22.3—Lymphocytopenia.....................305 Section 22.4—Neutropenia..............................309 Part IV: Bleeding and Clotting Disorders Chapter 23—What Are Hereditary Bleeding and Clotting Disorders?...............................................317 Chapter 24—Hemophilia............................................................323 Chapter 25—Von Willebrand Disease........................................335 Chapter 26—Factor V Leiden.....................................................341 Chapter 27—Factor Deficiencies................................................345 Chapter 28—Hereditary Hemorrhagic Telangiectasia.............353 Chapter 29—Bruises: When to See a Doctor.............................355 Chapter 30—Antiphospholipid Antibody Syndrome.................359 Chapter 31—Disseminated Intravascular Coagulation...........365 Chapter 32—Hypercoagulation..................................................371 Section 32.1—Excessive Blood Clotting..........372 Section 32.2—Deep Vein Thrombosis..............375 Section 32.3—Pulmonary Embolism...............380 Section 32.4—Preventing and Treating Blood Clots................................385 viii

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