Blood and Bone Marrow Pathology: Expert Consult: Online and Print, 2nd Edition PDF
Preview Blood and Bone Marrow Pathology: Expert Consult: Online and Print, 2nd Edition
Blood and Bone Marrow PATHOLOGY Commissioning Editor: Michael Houston Development Editors: Ben Davie & Rachael Harrison Editorial Assistant: Kirsten Lowson Project Manager: Anita Somaroutu Design: Kirsteen Wright Illustration Manager: Bruce Hogarth Illustrator: Robert Britton Marketing Managers (UK/USA): Gaynor Jones & Cara Jespersen SECOND EDITION Blood and Bone Marrow PATHOLOGY Anna Porwit MD, PhD Professor Department of Pathology Karolinska University Hospital and Institute Stockholm, Sweden; Department of Laboratory Medicine and Pathobiology University of Toronto Toronto, ON, Canada Jeffrey McCullough MD Professor of Laboratory Medicine and Pathology American Red Cross Professor of Transfusion Medicine University of Minnesota Minneapolis, MN, USA Wendy N. Erber MD, DPhil, FRCPA, FRCPath Consultant Hematologist Addenbrooke’s Hospital; Hematology Department University of Cambridge Cambridge, UK For additional online content visit expertconsult.com Edinburgh London New York Oxford Philadelphia St Louis Sydney Toronto 2011 An Imprint of Elsevier Limited © 2011, Elsevier Limited All rights reserved. First edition 2002 Second edition 2011 The right of Anna Porwit, Jeffrey McCullough and Wendy N. Erber to be identified as authors of this work has been asserted by them in accordance with the Copyright, Designs and Patents Act 1988. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Details on how to seek permission, further information about the Publisher’s permissions policies and our arrangements with organizations such as the Copyright Clearance Center and the Copyright Licensing Agency, can be found at our website: www.elsevier.com/permissions. This book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be noted herein). Notices Knowledge and best practice in this field are constantly changing. As new research and experience broaden our understand- ing, changes in research methods, professional practices, or medical treatment may become necessary. Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using any informa- tion, methods, compounds, or experiments described herein. In using such information or methods they should be mindful of their own safety and the safety of others, including parties for whom they have a professional responsibility. With respect to any drug or pharmaceutical products identified, readers are advised to check the most current information provided (i) on procedures featured or (ii) by the manufacturer of each product to be administered, to verify the recom- mended dose or formula, the method and duration of administration, and contraindications. It is the responsibility of practitioners, relying on their own experience and knowledge of their patients, to make diagnoses, to determine dosages and the best treatment for each individual patient, and to take all appropriate safety precautions. To the fullest extent of the law, neither the Publisher nor the authors, contributors, or editors, assume any liability for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein. Churchill Livingstone British Library Cataloguing in Publication Data Blood and bone marrow pathology. 1. Blood – Diseases. 2. Bone marrow – Diseases. 3. Blood – Diseases – Histopathology. 4. Bone marrow – Diseases – Histopathology. I. Porwit, Anna. II. McCullough, Jeffrey J. III. Erber, Wendy N., 1957– 616.1′5 – dc22 ISBN-13: 9780702031472 Working together to grow The libraries in developing countries publisher’s policy is to use www.elsevier.com | www.bookaid.org | www.sabre.org paper manufactured from sustainable forests Printed in China Last digit is the print number: 9 8 7 6 5 4 3 2 1 Preface In the time since the first edition of Blood and Bone Marrow major driving force behind Blood and Bone Marrow Pathology. Pathology was published in 2002, major advances have been It is with immense sadness we note the untimely death of made in all facets of the field of hematology. Much of this Sunitha during the production of this second edition. His has resulted from progress in molecular genetics which has death has been a tremendous loss to hematology. enhanced our understanding of the pathological basis of The book is divided into sections on normal blood and hematological disorders. The knowledge of the molecular bone marrow, pathology of the bone marrow, disorders of basis of hematological diseases is now being used to both erythroid cells and leukocytes, abnormalities of hemostasis diagnose and classify non-malignant and malignant hema- and immunohematology. Within each section there are tological disorders. This has had a major impact on the chapters devoted to specific aspects of each of these areas hemopoietic tumors where the World Health Organization and which have been written by internationally recognized classification is in large part based on this new biological experts. We are most grateful to them for their outstanding information. This second edition of Blood and Bone Marrow contributions and the time they have devoted to this project. Pathology has therefore been significantly updated and We are also immensely grateful to the publishers and espe- revised to incorporate these advances. Many chapters have cially Michael Houston, Ben Davie and Rachael Harrison for been totally rewritten to encapsulate the advances in the their enormous help in bringing this project to fruition. We understanding of the fundamentals of the pathology of hope this second edition of Blood and Bone Marrow Pathology blood and bone marrow in health and disease. This book will be of benefit to clinical and laboratory hematologists, truly focuses on the pathology of blood and bone marrow. hematopathologists and those in training in gaining a better Although clinical aspects of disease are alluded to along with understanding of the pathology of blood and bone marrow. treatment approaches, this is only given as a guide to the reader. The book is aimed at bridging pure cytology and Anna Porwit histology with clinical hematology diagnostics. Jeffrey McCullough The book was originally to be co-edited by Professor Wendy N. Erber Sunitha Wickramasinghe, co-editor of the first edition and a 2011 Contributors Kenneth C. Anderson MD, PhD Scott D. Boyd MD, PhD Director, Jerome Lipper Multiple Myeloma Center Assistant Professor of Pathology Dana-Farber Cancer Institute Department of Pathology Kraft Family Professor of Medicine Stanford University Harvard Medical School Stanford, CA, USA Boston, MA, USA Shannon M. Buckley PhD Daniel A. Arber MD Postdoctoral Research Fellow Professor and Associate Chair of Pathology Department of Pathology Department of Pathology New York University Medical Center Stanford University New York, NY USA Stanford, CA, USA Guntram Büsche Donald M. Arnold MDCM, MSc, FRCPC Lecturer in Hematopathology Assistant Professor, Department of Medicine Institute of Pathology Division of Hematology and Thromboembolism Medizinische Hochschule Hannover Michael G. DeGroote School of Medicine Hannover, Germany McMaster University Magdalena Czader MD, PhD Canadian Blood Services Director, Division of Hematopathology Hamilton, ON, Canada Department of Pathology and Laboratory Medicine Barbara J. Bain MB BS, FRACP, FRCPath Indiana University School of Medicine Professor in Diagnostic Hematology Indianapolis, IN, USA Imperial College Geoff Daniels PhD, FRCPath Honorary Consultant Hematologist Head of Molecular Diagnostics and Senior Research Fellow Department of Hematology Bristol Institute for Transfusion Sciences and IBGRL St Mary’s Hospital NHS Blood and Transplant London, UK Bristol, UK Marie Christine Béné Pharm Sci D, PhD Faith E. Davies MBBCh, MD, MRCP, FRCPath Professor of Immunology Hemato-oncology Unit Immunology Laboratory Royal Marsden Hospital Faculty of Medicine London, UK Nancy University and University Hospital Vandoeuvre-lès-Nancy, France Jean Delaunay MD, PhD Professor of Genetics David H. Bevan FRCP FRCPath INSERM Director and Consultant Hematologist Faculté de Médecine Paris-Sud Centre for Hemostasis and Thrombosis Univ Paris-Sud Guy’s and St Thomas’ NHS Foundation Trust Le Kremlin-Bicêtre, France London, UK Wendy N. Erber MD, DPhil, FRCPA, FRCPath Oliver Bock MD Consultant Hematologist Professor for Transplantation Pathology Addenbrooke’s Hospital Head Central Tissue and Specimen Bank Hematology Department Institute of Pathology University of Cambridge Medizinische Hochschule Hannover Cambridge, UK Hannover, Germany Gines Escolar MD, PhD Jeremiah C. Boles MD Head of Department Hematology/Oncology Fellow Servicio de Hemoterapia y Hemostasia Division of Hematology/Oncology Hospital Clinic, University of Barcelona, Medical School University of North Carolina at Chapel Hill Barcelona, Spain Chapel Hill, NC, USA David J. P. Ferguson BSc, PhD, DSc Gerben Bouma PhD Professor of Ultrastructural Morphology Research Associate Nuffield Department of Clinical Laboratory Science Molecular Immunology Unit University of Oxford UCL Institute of Child Health John Radcliffe Hospital London, UK Oxford, UK Contributors Edward C. Gordon-Smith MA, BSc, FRCP, FRCPath, FMedSci D. Mark Layton FRCP, FRCPCH Emeritus Professor of Hematology Consultant and Reader in Hematology St George’s College, University of London Department of Hematology London, UK Imperial College London, UK Ralph Green MD, PhD, FRCPath Professor and Chair Emeritus Peter K. MacCallum MD, FRCP, FRCPath Department of Pathology and Laboratory Medicine Department of Hematology University of California Davis School of Medicine Wolfson Institute of Preventive Medicine Sacramento, CA, USA Barts and The London School of Medicine and Dentistry Queen Mary College, University of London Carolyn S. Grove MBBS, FRACP, FRCPA London, UK Clinical Research Training Fellow Wellcome Trust Sanger Institute Alison May PhD Hinxton, UK Senior Research Fellow Department of Hematology Georgina W. Hall MBBS, PhD, FRCP, FRCPath, FRCPCH Cardiff University School of Medicine Consultant Paediatric Hematologist Cardiff, UK Honorary Senior Lecturer Paediatric Hematology/Oncology Unit Jeffrey McCullough MD Children’s Hospital Professor of Laboratory Medicine and Pathology John Radcliffe Hospital American Red Cross Professor of Transfusion Medicine Oxford, UK University of Minnesota Minneapolis, MN, USA Nancy M. Heddle MSc., FCSMLS(D) Professor Mufaddal T. Moonim MD, FRCPath Michael G. DeGroote School of Medicine Consultant Histopathologist Department of Medicine, Department of Pathology and Department of Histopathology Molecular Medicine Guy’s and St Thomas’ Hospitals McMaster University London, UK Hamilton, ON, Canada Jane C. Moore BSc, ART Hans-Peter Horny MD Assistant Professor Professor of Pathology Michael G. DeGroote School of Medicine Institute of Pathology Department of Medicine, Department of Pathology and Ansbach, Germany Molecular Medicine McMaster University Carolyn Katovich Hurley PhD, D(ABHI) Hamilton, ON, Canada Professor of Oncology and Microbiology and Immunology Georgetown University Medical Center Ishac Nazi PhD Washington, DC, USA Assistant Professor Michael G. DeGroote School of Medicine John G. Kelton MD, FRCPC Department of Medicine, Department of Pathology and Professor Molecular Medicine Department of Medicine Department of Biochemistry and Biomedical Sciences Department of Pathology and Molecular Medicine McMaster University Michael G. DeGroote School of Medicine Hamilton, ON, Canada McMaster University Hamilton, ON, Canada Adrian C. Newland CBE, MA, FRCP, FRCPath Professor of Hematology Nigel S. Key MB, ChB, FRCP Department of Hematology Harold R Roberts Distinguished Professor The Royal London Hospital Department of Medicine, Division of Hematology/Oncology London, UK University of North Carolina at Chapel Hill Chapel Hill, NC, USA Eva Norström MD, PhD Medical Doctor Hans H. Kreipe MD Department of Laboratory Medicine Professor of Pathology, Director Institute of Pathology Clinical Chemistry Malmö Medizinische Hochschule Hannover Lund University Hannover, Germany Lund, Sweden Hans M. Kvasnicka MD Attilio Orazi MD, FRCPath Professor of Pathology Professor of Pathology and Laboratory Medicine and Vice- Senkenberg Institute of Pathology Chair for Hematopathology University of Frankfurt Director, Division of Hematopathology Frankfurt, Germany Department of Pathology and Laboratory Medicine Weill Medical College of Cornell University New York, NY, USA x Contributors David J. Perry MD PhD, FRCPEdin, FRCPLond,FRCPath Swee Lay Thein MB, BS, FRCP, FRCPath, DSc, FMedSci Consultant Hematologist Professor of Molecular Hematology/Consultant Hematologist Department of Hematology King’s College London/King’s College Hospital NHS Addenbrooke’s Hospital Foundation Trust Cambridge, UK James Black Centre London, UK Martin J. Pippard BSc, MB, ChB, FRCP, FRCPath Emeritus Professor of Hematology Adrian J. Thrasher PhD, FRCP, FRCPath, FMedSci University of Dundee Professor of Paediatric Immunology Dundee, UK Molecular Immunology Unit UCL Institute of Child Health Anna Porwit MD, PhD London, UK Professor Department of Pathology Jon D. van der Walt MB, BCh, FRCPat Karolinska University Hospital and Institute Consultant Histopathologist Stockholm, Sweden Department of Histopathology Department of Laboratory Medicine and Pathobiology Guy’s and St Thomas’ Hospitals University of Toronto London, UK Toronto, ON, Canada Catherine Verfaillie MD Phillip E. Posch PhD Professor of Medicine Assistant Professor of Oncology Director Georgetown University School of Medicine Stamcelinstituut Department of Oncology Katholieke Universiteit Leuven Washington, DC, USA Leuven, Belgium Drew Provan MD, FRCP, FRCPath James G. White MD Academic Hematology Unit – Pathology Group Regents Professor Blizard Institute of Cell and Molecular Science Departments of Laboratory Medicine and Pathology, and Barts and the London School of Medicine and Dentistry Pediatrics London, UK University of Minnesota School of Medicine Minneapolis, MN, USA Raffaele Renella MD, PhD MRC Molecular Hematology Unit The late Sunitha N. Wickramasinghe Weatherall Institute of Molecular Medicine Formerly Emeritus Professor of Hematology, University of University of Oxford, UK London Children’s Hospital Boston Visiting Professor of Hematology, University of Oxford Harvard Medical School Formerly Head of the Department of Hematology Boston, MA, USA St Mary’s Hospital Medical School Imperial College of Science, Technology and Medicine David R. Roper MSc, CSci, FIBMS London, UK Principal Biomedical Scientist Department of Hematology Bridget S. Wilkins MB BCh, DM, PhD, FRCPath Hammersmith Hospital Consultant Hematopathologist Imperial College Healthcare NHS Trust Department of Cellular Pathology London, UK Guy’s and St Thomas’ Hospitals NHS Foundation Trust London, UK Richard Rosenquist MD, PhD Professor of Molecular Hematology William G. Wood PhD Department of Genetics and Pathology Professor of Molecular Hematology Rudbeck Laboratory MRC Molecular Hematology Unit Uppsala University Weatherall Institute of Molecular Medicine Uppsala, Sweden University of Oxford John Radcliffe Hospital Benny Sørensen MD, PhD Oxford, UK Director of HRU Honorary Lecturer Gina Zini MD, PhD Associate Professor Professor of Clinical Pathology Hemostasis Research Unit (HRU) Institute of Hematology Centre for Hemostasis and Thrombosis Catholic University of Sacred Heart Guy’s and St Thomas’ NHS Foundation Trust Rome, Italy St Thomas’ Hospital London, UK xi Dedication to Sunitha N. Wickramasinghe human bone marrow, first published in 1973 and revised in 1975, are still widely utilized by scientists and clinical hematologists eager to understand the fundamentals of this work. Sunitha was also a superb methodologist. In the last 20 years, he became the leading authority on electron microscopy of the blood forming tissues. Driven by his scientific interest, he was always a hard worker. When he visited me in Ulm to analyze the specimens of my collection of bone marrow of patients with congenital dyserythropoi- etic anemia, he started work early each morning; all members of the electron microscopy department were highly impressed by his immense skill, knowledge and enthusiasm in this field. I last met Sunitha in November 2008 at the second sym- posium on congenital dyserythropoietic anemia. Although already very ill and suffering from complications of recent chemotherapy he gave two lectures. On the night after his last presentation, he was admitted to the local hospital in a small town on Lake Como in Italy. He returned to England and with the support of his wife Priyanthi (to whom he had dedicated his monograph) survived another six months. Sunitha was a talented teacher, keen to share his knowl- Sunitha N. Wickramasinghe, co-editor of the first edition of edge with students and younger colleagues. Not only were this book, died in June 2009, after a long and brave fight his postgraduate courses in the United Kingdom legendary, against a hematological neoplasm. but he also found the time to return to Sri Lanka for lectures Sunitha was born in Sri Lanka (former Ceylon) in 1941, at the College of Hematologists. His intellectual curiosity and received his medical training at the Royal College and and capacity for rigorous analysis, not only of the morphol- Ceylon University. In 1964 he moved to England, and after ogy of blood cells but also of other clinical and laboratory postgraduate clinical and research training in Cambridge observations, made him a highly respected partner of clini- and Leeds was appointed as Professor of Hematology at St cians and their patients. Mary’s Hospital in London, soon to become the Imperial Thanks to Sunitha’s friendly, always helpful, modest and College Medical School. After retirement, he took a position charming personality he had many friends all over the world. in the Weatherall Institute of Molecular Medicine at the We all miss him, but we are all happy to have had the oppor- University of Oxford. He knew of his fatal disease in 2000, tunity to work with him and to know him and his family. but continued to work on morphological and molecular aspects of hematopoesis until 2008. Prof. Emerit. Dr. med. Sunitha was an academic scholar in the genuine sense Hermann Heimpel FRCPath of the word. This is evident in the more than 200 interna- Medizinische Universitätsklinik tionally cited papers, mainly on abnormal red blood cell Ulm, Germany for mation and the associated diseases. His monographs on 2011
Description:The list of books you might like
