Biotechnology Bioengineering INDEX TO VOLUME 68 Biotechnology aoe Armaan Bioengineering Editor Douglas S. Clark ) il Engineering, Univ Editorial Board lames E. Bailey Maria-Regina Kula ETH-Ziiri P,a uline Doran larvey W. BSlaagnec h Douglas A. Lauffenburger lniversity of , uth V ales o Universit Adriculture mversity aul Ha A Viassacbusetts j Ho Nam Chang lonathan S. Dordick | nstitute Bernhard @. Palsson Rensselaer Polytechnic Institut Elettherios 1 Papoutsakis ‘ j | rk niversity © 290 | Todd , M. Przybycien UInsiavoe rsKiatry ubeof 1 KR) (M icorhnea el U’ niLv.e rsSihtuy ler ( Irnegte . le ion [ I 5 ] lapar lettrey A. Hubbell Alexander M. Klibanov ETH—Ziirich and Massachusetts Institute of ersily Founding Editor: Elmer | Postmaster Advertising Sales Reprints ) Manuscripts | ) ( ‘x All Other Correspondence Editorial Production, John Wiley Yiane Ge x) This paper meets the requirement of ANSI/NISO Z39.48-1992 (Permanence of Paper) Biotechnology and Bioengineering Author Index to Volume 68 Abdel-Fattah, W.R. Beun, J.J. Christensen, B. ; Fadil, M.; Nigam, P.; Banat, 1.M : Verhoef, E.V.; Van Loosdrecht, ; Nielsen, J.: Metabolic Network Analysis Isolation of Thermotolerant M.C.M.; Heijnen, J.J.: Stoichiometry of Penicillium chrysogenum Using Ethanologenic Yeasts and Use of and Kinetics of Poly-B-Hydroxybutyrate C-Labeled Glucose, 652 Selected Strains in Industrial Scale Metabolism Under Denitrifying Chung, J.D. Fermentation in an Egyptian Distillery, Conditions in Activated Sludge ; Design of Metabolic Feed Controllers 53] Cultures, 496 Application to High-Density Abian, O. See Mateo, C., 98 Bhat, S.G. See Upadhya, R., 430 Fermentations of Pichia pastoris, 298 Acha, V. Blahuta, N. See Champagne, C.P., 681 Conejeros, R. : Meurens, M.; Naveau, H.; Agathos, Bogle, I.D.L. See Steffens, M.A., 218 Vassiliadis V.S Dynamic Biochemical S.N.: ATR-FTIR Sensor Development Boll6k, M. See Stenberg, K., 204 Reaction Process Analysis and Pathway for Continuous On-Line Monitoring of Bonner, G. Modification Predictions, 285 Chlorinated Aliphatic Hydrocarbons in a ; Klibanov, A.M.: Structural Stability of Coutelle, C. See Aris, A., 689 Fixed-Bed Bioreactor, 473 DNA in Nonaqueous Solvents, 339 Cramer, S.M. See Shukla, A.A., 672 Acuna, M.E. See Auria, R., 448 Bourdillon, C. See De Lac ey, A.L., | Cui, Z.F. See Ghosh, R., 191 Agathos, S.N. See Acha, V., 473 Bourgois, A. See Argiro, L., 136 Aitken, M.D. See Marx, R.B., 308 Brion, F. See Champagne, C.P.., 68] Davison, B.H. Akkus, H. See Hacking. M.A.P.J., 84 Biichs, J. : Barton, J.W.; Klasson K.T Francisco Al-Rubeai, M. See Tey, B.T.. 31 ; Maier, U.; Milbradt, C.; Zoels, B \.B Influence of High Biomass Ansorge, M.B. Power Consumption in Shaking Flasks Concentrations on Alkane Solubilities : Kula, M.-R Production of Recombinant on Rotary Shaking Machines: I. Power Y L-Leucine Dehydrogenase from Bacillus Consumption Measurement in de Atauri, P. cereus in Pilot Scale Using the Unbaffled Flasks at Low Liquid : Sorribas, A.: Cascante, M Analy sis and Runaway Replication System / Viscosity, 589 Prediction of the Effect of Uncertain coli{pIET98}, 557 ; Maier, U.; Milbradt, C.; Zoels, B Boundary Values in Modeling a Arcos, J.A. Power Consumption in Shaking Flasks Metabolic Pathway, 18 ; Garcia, H.S.; Hill, C.G., Jr Continuous on Rotary Shaking Machines: II de Hulster, E. See van Hoek, P., 51 Enzymatic Esterification of Glycerol Nondimensional Description of Specific de Laat, W.T.A.M. See van Gulik, W.M with (Poly)Unsaturated Fatty Acids in a Power Consumption and Flow Regimes 602 Packed-Bed Reactor, 563 in Unbaffled Flasks at Elevated Liquid De Lacey, A.L. Argiro, L. Viscosity, 594 ; Detcheverry, M.; Moiroux, J.: Doerig, C.; Liabeuf, S.; Bourgois, A Biintemeyer, H. See Werner A., 59 Bourdillon, C Construction of Romette, J.L.: Production of Butler, M. See Yang, M., 370 Multicomponent Catalytic Films Based Sm37-GAPDH, a Major Therapeutical on Avidin-Biotin Technology for the larget in Human Schistosomiasis, 136 ‘amacho, F. Garcia See Fernandez, F.G Electroenzymatic Oxidation of Aris, A. Acién, 173 Molecular Hydrogen, | : Feliu, J.X.; Knight, A Coutelle, C.: ‘arswell, K.S. Dell, A. See Morrison, C.J., - Villaverde, A Exploiting Viral Papoutsakis, E.1 Culture of Human T DeMoss, J.A. See Han, S.J.. 115 Cell largeting Abilities in a Single Cells in Stirred Bioreactors for Cellular Detcheverry, M. See De Lacey, A.1 Polypeptide, Non-Infectious, Immunotherapy Applications: Shear, Dillon, R. Recombinant Vehicle for Proliferation, and the IL-2 Receptor, Fauci, L.: A Microscale Model of Integrin-Mediated DNA Delivery and 3IR Bacterial and Biofilm Dynamics in Gene I xpression, 6389 ‘ascante, M. See de Atauri, P.. | Porous Media, 536 Auria, R. ‘hampagne, C.P. Dinter, A. See Prati, E.G.P., 239 ‘i rere, G Morales, M.; Acuna, M.I Blahuta, N.: Brion, F.: Gagnon, ¢ \ Diogo, M.M. Revah, S Influence of Mixing and Vortex-Bow! Disk Atomizer System fot : Queiroz. J.A.: Monteiro, G.A.: Martins Water Addition on the Removal the Production of Alginate Beads in a S.A M Ferreira, G.N M Prazeres, Rate of Toluene Vapors in a Biofilter, 1500-Liter Fermentor, 681 D.M.F.: Purification of a Cystic Fibrosis 448 ‘handran, K. Plasmid Vector for Gene Therapy Using Smets, B.I Single-Step Nitrification Hydrophobic Interaction Models I rroneously Describe Batch Chromatography, 576 Bailey, J.E. See Prati, E.G.P., 239 Ammonia Oxidation Profiles when Di Paolo, M.L. See Vianello, | . 488 Banat, I.M. See Abdel-Fattah, W.R., 53 Nitrite Oxidation Becomes Rate Dodds, M.G. Bannister, S.J. Limiting, 396 : Grobe, K.J.: Stewart P.S Modeling ; Wittrup, K.D Glutathione Excretion in Chang, H.N. See Han, S.J., 115 Biofilm Antimicrobial Resistance, 456 Response to Heterologous Protein Chao, Y. Doerig, C. See Argiro, | 136 Secretion in Saccharomyces ce reviside : Ishida, T.; Sugano, Y.; Shoda, M Domingues, L. 389 Bacterial Cellulose Production by ; Lima, N.; Teixeira, J.A.: Contamination Barton, J.W. See Davison, B.H., 279 Acetobacter xylinum in a 50-1 of a High-Cell Density Continuous Bédard, C. See Elias, C.B., 381 Internal-Loop Airlift Reactor, 345 Bioreactor, 584 Belleville, M.-P. See Paolucci-Jeanjean, D.. Cheon, Y.H. See Kim, G.J., 211 Dordick, J.S. See Novick, S.J., 665 71 Choi, J.-i. See Lee. S.Y.. 466 Duvar, S. See Werner, A., 59 Biotechnology and Bioengineering, Vol. 68 , Pp. 709-712 (2000) Easton, R.L. See Morrison, C.J., 407 Oxygen-Dependent Inducible Promoter Lim, T.-k. Elias, C.B. System, the Modified nar Promoter in a ; Nakamura, N.; Matsunaga, T Use of - Zeiser, A.: Bédard, C.; Kamen, A.A.: Mutant Escherichia coli, 115 Anion Exchange Resin-Packed Capillary Enhanced Growth of Sf-9 Cells to a Hatano, T. See Matsunaga, T., 647 Column for Rapid Detection of Maximum Density of 5.2 x 10° Cells Heijnen, J.J. See Picioreanu, C., 355 Anti-Double-Stranded DNA Antibody in per mL and Production of : See Beun, J.J., 496 Systemic Lupus Erythematosus Serum, 8-Galactosidase at High Cell Density by ; See van Gulik, W.M., 602 > Fed Batch Culture, 381 Hill, C.G., Jr. See Arcos, J.A., 563 Lima, N. See Domingues, L., 584 Eschenhagen, T. See Zimmermann, W.H., Liu, A.D. See Long-McGie, J., 121 106 Ikasari, L. Liu, B.-L. ; Tzeng, Y.-M.: Characterization Study of ; Mitchell, D.A Two-Phase Model of the Fadil, M. See Abdel-Fattah, W.R., 53 Kinetics of Growth of Rhizopus the Sporulation Kinetics of Bacillus Fan, Z. oligosporus in Membrane Culture, 619 thuringiensis, 11 ; Oguntimein, G.B.; Reilly, P.J Ingram, L.O. See Zaldivar, J., 524 Lofgren, J. See Gawlitzek, M., 63 Characterization of Kinetics and Loh, K.-C. See Wang, S.-J., 437 Thermostability of Acremonium strictum Ilosrhii,d a,R . TS.e eS eeL eoCnhia,o ,O .,Y .,6 603 45 Long-McGie, J. Glucooligosaccharide Oxidase, 231 ; Liu, A.D.; Schellenberger, V.: Rapid In Fauci, L. See Dillon, R., 536 Vivo Evolution of a B-Lactamase Using Feliu, J.X. See Aris, A., 689 Kamen, A.A. See Elias, C.B., 381 Phagemids, 121 Fernandez, F.G. Acién Keesman, K.J. Liinsdorf, H. See Werner, A., 59 ; Pérez, J.A. Sanchez: Sevilla, J.M : Spanjers, H.: Endogenous Model State Fernandez; Camacho, F. Garcia; Grima, and Parameter Estimation from an Maier, U. See Biichs, J., 589 E. Molina: Modeling of Extensive Batch Experiment, 422 : See Biichs, J., 594 Eicosapentaenoic Acid (EPA) Kim, G.J. Malacarne, C. See Vianello, F., 488 Production from Phaeodactylum ; Cheon, Y.H.; Kim, H.-S. Directed Mardikar, S.H. tricornutum Cultures in Tubular Evolution of a Novel N-Carbamylase/ : Niranjan, K.: Observations on the Shear b-Hydantoinase Fusion Enzyme for Photobioreactors. Effects of Dilution Damage to Different Animal Cells in a Rate, Tube Diameter, and Solar Functional Expression with Enhanced Concentric Cylinder Viscometer, 697 Irradiance, 173 Stability, 211 Martinez, A. See Zaldivar, J., 524 Fernandez-Lafuente, R. See Mateo, C., 98 Kim, H.-S. See Kim, G.J., 211 Martins, S.A.M. See Diogo, M.M., 576 Kinney, K.A. See Song, J., 508 Ferreira, G.N.M. See Diogo, M.M., 576 Marx, R.B. Fink, C. See Zimmermann, W.H., 106 Klasson, K.T. See Davison, B.H., 279 Aitken, M.D.: A Material-Balance Klibanov, A.M. See Bonner, G., 339 Fraga, E.S. See Steffens, M.A., 218 Approach for Modeling Bacterial Francisco, A.B. See Davison, B.H., 279 Knight, A. See Aris. A., 689 Chemotaxis to a Consumable Substrate Frere, G. See Auria, R., 448 Kohda, J. See Teshima, T., 184 in the Capillary Assay, 308 Fukuda, H. See Teshima, T.. 184 Kondo, A. See Teshima, T., 184 Matasci, M. See Prati, E.G.P., 239 Kralisch, D. See Zimmermann, W.H., 106 Mateo, C. Gagnon, C. See Champagne, C.P., 681 Kula, M.-R. See Ansorge, M.B., 557 Abian, O.; Fernandez-Lafuente, R.; Galbe, M. See Stenberg, K., 204 Guisan, J.M.: Reversible Enzyme Garcia, H.S. See Arcos, J.A., 563 Immobilization via a Very Strong and Gawlitzek, M. ; Modeling and Optimization of Nondistorting lonic Adsorption on ; Ryll, T.; Lofgren, J.; Sliwkowski, M.B Anaerobic Digested Sludge Converting Support—Polyethylenimine Composites. Ammonium Alters N-Glycan Structures Starch to Hydrogen, 269 9S of Recombinant TNFR-IgG Lee, G.M. See Lee, M.S., 260 Matsumoto, M. See Matsunaga, T., 64 Degradative Versus Biosynthesis Lee, J. See Han, S.J., 115 Matsunaga, T. Mechanisms, 637 Lee, M.S. ; Hatano, T.: Yamada, A.; Matsumoto, Georgiou, G. See Pressman, J.G., 548 ; Lee, G.M.: Hyperosmotic Pressure M.: Microaerobic Hydrogen Production Ghosh, R. Enhances Immunoglobulin Transcription by Photosynthetic Bacteria in a ; Cui, Z.F Purification of Lysozyme Rates and Secretion Rates of KR12H-2 Double-Phase Photobioreactor, 647 Using Ultrafiltration, 191 Transfectoma, 260 ; See Lim, T.-k., 571 Glatz, C.E. See Zhang, C.-M., 52 Lee, S.C. See Lee, S.Y., 466 McMaster, W.R. See Morrison, C.J., 407 Gonchar, M.V. See Moroz, O.M., 44 Lee, S.H. See Lee, S.Y., 466 Meurens, M. See Acha, V.. 473 Grima, E. Molina See Fernandez, F.G Lee, S.Y. Milbradt, C. See Biichs, J.. 589 Acién, 173 ; Wong, H.H.; Choi, J.-i.; Lee, S.H.; Lee, : See Biichs, J., 594 Grobe, K.J. See Dodds, M.G., 456 S.C.; Han, C.S.: Production of Mitchell, D.A. Guisan, J.M. See Mateo, C., 98 Medium-Chain-Length ; von Meien, O.F.: Mathematical Polyhydroxyalkanoates by Modeling as a Tool to Investigate the Hacking, M.A.P.J. High-Cell-Density Cultivation of Design and Operation of the Zymotis ; Akkus, H.: van Rantwijk, F.; Sheldon, Pseudomonas putida Under Phosphorus Packed-Bed Bioreactor for Solid-State R.A.: Lipase and Esterase-Catalyzed Limitation, 466 Fermentation, 127 Acylation of Hetero-Substituted Lehmann, J. See Werner, A., 59 ; See Ikasari, L., 619 Nitrogen Nucleophiles in Water and Leoni, O. Mohamed, N. Organic Solvents, 84 ; lori, R.; Palmieri, S Hydrolysis of ; Rainier, T.R., Jr.; Ross, J.M Novel Han, C.S. See Lee, S.Y., 466 Glucosinolates Using Nylon- Experimental Study of Han, S.J. Immobilized Myrosinase to Produce Receptor-Mediated Bacterial Adhesion ; Chang, H.N.; DeMoss, J.A.; Suh, E.J.: Pure Bioactive Molecules, 660 Under the Influence of Fluid Shear, 628 Lee, J.: Development and Li, S.-B. See Xin, J.-Y., 78 Moiroux, J. See De Lacey, A.L., | Characterization of an Liabeuf, S. See Argiro, L., 136 Monteiro, G.A. See Diogo, M.M., 576 AUTHOR INDEX Morales, M. See Auria, R., 448 Picioreanu, C. Accumulation, Distribution, and Moroz, O.M. : van Loosdrecht, M.C.M.: Heijnen, J.J Activity: Linking Biofilm Properties to ; Gonchar, M.V.; Sibirny, A.A Efficient \ Theoretical Study on the Effect of Bioreactor Performance, 508 Bioconversion of Ethanol to Surface Roughness on Mass Transport Sorribas, A. See de Atauri, P., 18 Acetaldehyde Using a Novel Mutant and Transformation in Biofilms, 355 Spande, T.F. See Noronha, S.B., 316 Strain of the Methylotrophic Yeast Piredda, L. See Tey, B.T., 31 Spanjers, H. See Keesman, K.J., 422 Hansenula polymorpha, 44 Piret, J.M. See Morrison, C.J., 407 Speitel, G.E., Jr. See Pressman, J.G., 548 Morris, H.R. See Morrison, C.J.. 407 Prati, E.G.P. Steffens, M.A. Morrison, C.J. ; Matasci, M.: Suter, T.B.; Dinter, A.: ; Fraga, E.S.; Bogle, 1.D.1 Synthesis of ; Easton, R.L.; Morris, H.R.; McMaster, Sburlati, A.R.; Bailey, J.E.: Engineering Bioprocesses Using Physical Properties W.R.; Piret, J.M.; Dell, A.: Modification of Coordinated Up- and Data, 218 of a Recombinant GPI-Anchored Down-Regulation of Two Stenberg, K. Metalloproteinase for Secretion Alters Glycosyltransferases of the : Boll6k, M.; Réczey, K.; Galbe, M the Protein Glycosylation, 407 O-Glycosylation Pathway in Chinese Zacchi, G.: Effect of Substrate and Moussy, Y. Hamster Ovary (CHO) Cells, 239 Cellulase Concentration on ; Bioartificial Kidney. I. Theoretical Prazeres, D.M.F. See Diogo, M.M., 576 Simultaneous Saccharification and Analysis of Convective Flow in Hollow Pressman, J.G. Fermentation of Steam-Pretreated Fiber Modules: Application to a ; Georgiou, G.; Speitel, G.E., Jr.: A Softwood for Ethanol Production, 204 Bioartificial Hemofilter, 142 Hollow-Fiber Membrane Bioreactor for Stewart, P.S. See Dodds, M.G., 456 Bioartificial Kidney. Il. A Convective the Removal of Trichloroethylene from Strauss, M. See Werner, A., 59 Flow Model of a Hollow Fiber the Vapor Phase, 548 Sugano, Y. See Chao, Y., 345 Bioartificial Renal Tubule, 153 Pronk, J.T. See van Hoek, P., 517 Suh, E.J. See Han, S.J., 115 Miithing, J. See Werner, A., 59 Sunasara, K.M. See Shukla, A.A., 672 Suter, T.B. See Prati, E.G.P., 239 Queiroz, J.A. See Diogo, M.M., 576 Nabetani, H. See Nishizawa, K., 92 Nagajyothi See Upadhya, R., 430 Nakajima, M. See Nishizawa, K., 92 Rainier, T.R., Jr. See Mohamed, N., 628 TTeaigxuecihria,, JH..A .S eeS ee TeDsohmiimna,g uesT, 18L.,4 584 Nakamura, N. See Lim, T.-k., 571 Réczey, K. See Stenberg, K., 204 Teshima, T. NNiaevlesaeun,, JH.. SeSee e OAscthear,g aaVr.d,, 47S. . RReeimllmye,r sP,.J . US.e eS eeF anZ, imZ.m,e r2m3a1 nn, W.H., 106 Kohda, J Kondo, A.; Taguchi, H.; Yohda, M.; Fukuda, H Preparation of : See Christensen, B., 652 Reslewic, S.A. See Zhang, C.-M., 52 Nigam, P. See Abdel-Fattah, W.R., 531 Revah, S. See Auria, R., 448 HTohlerom-ucsh aptehre ornmionp-hIimlmuos bilized Niranjan, K. See Mardikar, S.H., 697 Rigo, A. See Vianello, F., 488 Microspheres with High Ability to Nishizawa, K. Riley, G.L. Facilitate Protein Refolding, 184 : Nakajima, M.; Nabetani, H.: A : Tucker, K.G.; Paul, G.¢ Thomas, C.R Tey, B.T. Forced-Flow Membrane Reactor for Effect of Biomass Concentration and Singh, R.P.; Piredda, L.; Piacentini, M Transfructosylation Using Ceramic Mycelial Morphology on Fermentation Al-Rubeai, M Influence of Bcl-2 on Membrane, 92 Broth Rheology, 160 Cell Death During the Cultivation of a Noronha, S.B. Rios, G.M. See Paolucci-Jeanjean, D., 7 Chinese Hamster Ovary Cell Line ; Yeh, H.J.C.; Spande, T.F.; Shiloach, J Robson, G.D. See Wiebe, M.G., 245 Expressing a Chimeric Antibody, 31 Investigation of the TCA Cycle and the Roca, C. See Ostergaard, S., 252 Thomas, C.R. See Riley, G.L., 160 Glyoxylate Shunt in Escherichia coli Romette, J.L. See Argiro, | BL21 and JM109 Using ‘*°C-NMR/MS, Roennow, B. See Ostergaard, S.. TTruicnkceir,, AK.P..GJ.. SSeeee RWiileebye,, G.ML..G,. . 1602 45 Ross, J.M. See Mohamed, N., 628 316 Tzeng, Y.-M. See Liu, B.-L.. 11 Novick, S.J. Rupp, R.G. See Shukla, A.A., 672 : Dordick, J.S Investigating the Effects Ryll, T. See Gawlitzek, M., 637 of Polymer Chemistry on Activity of Upadhya, R. Biocatalytic Plastic Materials, 665 Sburlati, A.R. See Prati, E.G.P., 239 ; Nagajyothi; Bhat, S.G Stabilization of p-Amino Acid Oxidase and Catalase in Scarpa, M. See Vianello, F., 488 Permeabilized Rhodotorula gracilis Oguntimein, G.B. See Fan, Z.. Schellenberger, V. See Long-McGie, J Cells and Its Application for the Olsson, L. See Ostergaard, S.., 121 Ostergaard, S. Sevilla, J.M. Fernandez See Fernandez. Preparation of a-Ketoacids, 430 : Roca, C.; Ronnow, B.: Nielsen, J.: F.G. Acién, 173 Olsson, L.: Physiological Studies in Sheldon, R.A. See Hacking, M.A.P.J., 84 van Dijken, J.P. See van Hoek, P.. 5 Aerobic Batch Cultivations of Shiloach, J. See Noronha, S.B., 316 van Gulik, W.M. Saccharomyces cerevisiae Strains Shoda, M. See Chao, Y., 345 ; de Laat, W.T.A.M.; Vinke, J.1 Harboring the MEL/ Gene, 252 Shukla, A.A. Heijnen, J.J Application of Metabolic ; Sunasara, K.M.; Rupp, R.G.; Cramer Flux Analysis for the Indentification of Palmieri, S. See Leoni, O., 660 S.M.: Hydrophobic Displacement Metabolic Bottlenecks in the Paolucci-Jeanjean, D. Chromatography of Proteins, 672 Biosynthesis of Penicillin-G, 602 : Belleville, M.-P.; Zakhia, N.: Rios, Shuster, J. See Wiebe, M.G., 245 van Hoek, P. G.M.: Kinetics of Cassava Starch Sibirny, A.A. See Moroz, O.M., 44 : de Hulster, E.: van Dijken, J.P.; Pronk Hydrolysis with Termamyl Enzyme, 71 Singh, R.P. See Tey, B.T., 31 J.T.: Fermentative Capacity in Papoutsakis, E.T. See Carswell, K.S., 328 Sliwkowski, M.B. See Gawlitzek, M.., High-Cell-Density Fed-Batch Cultures Paul, G.C. See Riley, G.L., 160 Smets, B.F. See Chandran, K., 396 of Baker's Yeast, 517 Pérez, J.A. Sanchez See Fernandez, F.G. Song, J. van Loosdrecht, M.C.M. See Picioreanu, Acién, 173 : Kinney, K.A Effect of Vapor-Phase C. soo Piacentini, M. See Tey, B.T., 31 Bioreactor Operation on Biomass : See Beun, J.J.. 496 AUTHOR INDEX van Rantwijk, F. See Hacking, M.A.P.J., Cultivation of Immortalized Human Yeh, H.J.C. See Noronha, S.B., 316 84 Hepatocytes HepZ on Macroporous Yohda, M. See Teshima, T., 184 Vassiliadis, V.S. See Conejeros, R., 285 CultiSpher G Microcarriers, 59 Verhoef, E.V. See Beun, J.J., 496 Wiebe, M.G. Zacchi, G. See Stenberg, K., 204 Vianello, F. : Robson, G.D.; Shuster, J.; Trinci, A.P.J.: Zakhia, N. See Paolucci-Jeanjean, D., 7 ; Zennaro, L.; Di Paolo, M.L.; Rigo, A.; Growth-Rate-Independent Production of Zaldivar, J. Malacarne, (¢ Scarpa, M.: Preparation, Recombinant Glucoamylase by ; Martinez, A.; Ingram, L.O.: Effect of Morphological Characterization, and Fusarium venenatum JeRS 325, 245 Alcohol Compounds Found in Activity of Thin Films of Horseradish Wittrup, K.D. See Bannister, S.J., 389 Hemicellulose Hydrolysate on the Peroxidase, 488 Wong, H.H. See Lee, S.Y., 466 Growth and Fermentation of Villaverde, A. See Aris, A., 689 Ethanologenic Escherichia coli, 524 Vinke, J.L. See van Gulik, W.M., 602 Xin, J.-Y. Zeiser, A. See Elias, C.B., 381 von Meien, O.F. See Mitchell, D.A., 127 Zennaro, L. See Vianello, F., 488 ; Li, S.-B.; Xu, Y.; Wang, L.-I Zhang, C.-M. Enzymatic Resolution of Wang, L.-L. See Xin, J.-Y., 78 (S)-(+)-Naproxen in a Trapped ; Reslewic, S.A.; Glatz, C.E.: Suitability Wang, S.-J. of Immobilized Metal Affinity \queous—Organic Solvent Biphase ; Loh, K.-C.: Growth Kinetics of Chromatography for Protein Purification Continuous Reactor, 78 Pseudomonas putida in Cometabolism from Canola, 52 Xu, Y. See Xin, J.-Y., 78 of Phenol and 4-Chlorophenol in the Zimmermann, W.H. Presence of a Conventional Carbon ; Fink, C.; Kralisch, D.; Remmers, Source, 437 Yamada, A. See Matsunaga, T., 647 Weil, J., Eschenhagen, T.: Three Weil, J. See Zimmermann, W.H., 106 Yang, M. Dimensional Engineered Heart Tissue Werner, A. : Butler, M.: Effects of Ammonia on from Neonatal Rat Cardiac Myocytes, 106 ; Duvar, S.; Miithing, J.; Biintemeyer, H.; CHO Cell Growth, Erythropoietin Zoels, B. See Biichs, J., 589 Liinsdorf, H.; Strauss, M.: Lehmann, J Production, and Glycosylation, 370 ; See Biichs, J., 594 AUTHOR INDEX Biotechnology and Bioengineering Subject Index to Volume 68 Acetaldehyde, 44 Bioreactor operation, 127 Enzymatic electrocatalysis, | Acetate, 316 Bioreactor optimization, 697 Enzyme, 71 Acetobacter, 345 Bioremediation, 536 Enzymes in organic solvents, 665 Acremonium strictum, 23 B-lactamase, 121 Erythropoietin, 370 Activated sludge, 422 Blood ultrafiltration, 142 Escherichia coli, 524 Adenovirus gene transfer, 106 ESR, 488 AFM, 488 Ethanol, 44, 524, 531 “~~ 3 Agitation, 328 °C labeling, 652 Ethanol fermentation, 204 Airlift bioreactor, 11, 584 ( ‘2GnT overexpression, 239 Ethylene glycol, 339 Airlift reactor, 345 ( ‘anola, 52 Extant respirometry, 396 a-ketoacid preparation, 430 ( ‘apillary assay, 308 Alcohol, 269 ( ‘arbon balance, 508 Feast/famine conditions, 496 Alkaline phosphatase conjugated DNA, 571 ( ‘arbon source, 602 Fed-batch, 115 Alkane, 279 ( ‘ardiac myocytes, 106 Fed batch culture, 381 Amino acid metabolism, 59 ( “atalase, 430 Fermentation, 298, 524, 531] Ammonia, 370 ( ‘atechol, 524 Fermentative capacity, high-cell-density Ammonium, 637 ( ‘ell adhesion, 628 fed-batch, 517 Anaerobic-digested sludge, 269 ( ‘ell culture, 106 Filamentous fermentation, 160 Animal cell damage, 697 ( ‘ell decay, 437 Filamentous microorganisms, 594 Anion exchange capillary column, 571 ( ell growth kinetics, 437 Flocculent S. cerevisiae, 584 Antibiotic resistance, 12] ( ‘ell line, 59 Flow cytometry, 31 Anti-dsDNA antibody, 57 ( ‘ell targeting, 689 Flow in a bioartificial kidney, 153 Antimicrobial, 456 ( ‘eramic membrane, 92 Flow in hollow fibers, 142 Apoptosis, 31 Cetyltrimethylammonium bromide, 430 Fluid shear, 628 Aqueous effluents, 473 ¢ ‘haperonin, 184 Fluorescence, 488 ATR-FTIR, 473 ( ‘hemostat, 602 FMDV, 689 Avidin-biotin affinity, | ( hemostat culture, 245 Forced-flow membrane reactor, 92 ( ‘hicken egg white, 191 Frequency response, 298 Bacillus thuringiensis, 11 ( ‘hinese hamster ovary (CHO), 637 Fuel cell, | Bacterial cellulose, 345 ( ‘hlorinated aliphatic hydrocarbons, 47 Fungal growth kinetics, 619 Bacterial chemotaxis, 308 ( ‘HO, 31, 407 Fungi, 448 Bacterial contamination, 584 C ‘HO cells, 239, 370 Furfuryl alcohol, 524 Baculovirus, 136 (C ometabolism, 437 Fusarium venenatum, 245 ( ‘ompartmentation, 652 Fusion protein, : Baculov irus expression vector SY stem, ( ‘onjugated linoleic acid, 563 Baker's yeast, 517 ( ‘ontinuous operation, 584 Batch experiment, 422 ( ‘ontinuous process, 78 GALS80, 2: bel-2, 31 ( ontrol, 298 BC pellet, 345 ( ‘onvection, 355 8-galactosidase, 381 Gas chromatography—mass spectrometry ( ystic fibrosis, 576 Bifunctional enzyme, 211 (GC-MS), 652 Bioartificial kidney, 142, 1! Gene therapy, 576 Bioartificial liver, 59 b-amino acid oxidase, 430 Geneticin selection, Bioartificial renal tubule, 15 Denitrification, 496 Glucoamylase, 245 Bioassay, |1 p-hydantoinase, 211 Glucooligosaccharide oxidase, 23 Biocatalysis, 665 Directed evolution, 121, 211 Glucose fermentation, 18 Biochemical pathways, 285 Directionally switching, 508 Glucose repression, 252 Bioconversion, 44 Disinfection, 456 Glucosinolates, 660 Biodegradation, 548 Disk turbine rheometer, 160 Glutaraldehyde stabilization, 430 Displacement chromatography, 672 Glutathione excretion, 389 Biofilm, 355, 456 Displacers, 672 Glycerol, 339 Biofilm model, 536 Distillery, 531 Glycolysis, 517 Biofilter, 448 DNA shuffling, 211 Glycosylation, 370, 407 Biofiltration, 279 DNA stability, 339 Glyoxylate, 316 Biokinetics, 396 DNA structure, 339 Growth-rate-independent production Biomass, 279, 524 Double-phase photobioreactor, 647 Guaiacol, 524 Biomass activity, 508 Dual rate-limitation, 396 Biomass yield, 508 Bioprocess monitoring, 473 Hansenula polymorpha, 44 Bioprocesses, 218 E. coli, 316 Heating, 681 Bioreactor, 660 Eicosapentaenoic acid, 173 Hemicellulose, 524 Bioreactor design, 127 Electrical wiring, | Hemofiltration, 142 Bioreactor monitoring, 47732 Endogenous process, 422 Henry's law, 279 Biotechnology and Bioengineering, Vol. 68, Pp. 713-715 (2000) Heterologous protein secretion, 389 Metal affinity, 52 Power consumption, 589, 594 High-cell-density culture, 466 Metalloproteinase, 407 Power law, 160 Hill equation, 11 Methanotrophs, 548 Power number, 589 Hollow fiber membrane, 548 Methylotrophic yeast, 44 Process optimization, 285 Horseradish peroxidase, 488 Microaerobic condition, 647 Process synthesis, 218 Human T cells, 328 Microspheres, 184 Proliferation, 328 Hydrazine, 84 MIGI, 252 Propane, 279 Hydrodynamic shear stress, 697 Mixing, 448 Protein fractionation, 191 Hydrogen, 269 Model, 456 Protein immobilization, 488 Hydrogen production, 647 Model validation, 18 Protein purification, 672 Hydrogenase immobilization, | Modeling, 437 Protein recovery, 52 Hydrolysis, 71 Modeling, Reynolds number, 589 Protein refolding, 184 Hydrophobic interaction, 67 Morphology, 160 Proteins, 672 Hydrophobic interaction chromatography, MS, 316 Pseudomonas putida, 466 576 Mucor miehei lipase, 563 Purification, 557 Hydroxylamine, 84 Multisequence alignment, 23 Hyperosmotic pressure, 260 Multivariate analysis, 473 Hypothermia, 59 Mutants, 44 Reaction-diffusion, 456 Myrosinase, 660 Receptor, 628 Recombinant glycoprotein, 637 Immersed boundary method, 536 Recombinant protein, 245, 689 Immobilization, 184, 660, 681 Naphthalene, 308 Recombinant protein production, 407 Immobilized enzymes, 78, 665 Naproxen, 78 Resistance, 456 Immortalized hepatocytes, 59 nar promoter, 115 Respiration, 647 Immunotherapy, 328 N-carbamylase, 211] Response-surface method, 269 Inducible promoter, 115 N-glycosylation, 637 Reversed-phase, 672 Inhibition, 204, 437 Nitrification, 396 Reversible immobilization of proteins, 98 Insect cell, 136 Nitriles. 660 RGD, 689 Integrin, 689 NMR, 316 Rheology, 160 Interleukin-2 receptor, 328 Non-natural reaction, 84 Rhizopus oligosporus, 619 lonic adsorption of proteins, 98 Nucleic acids, 576 Rhodotorula gracilis, 430 Irradiance, 173 Nutrient deprivation, 31 Runaway replication, large-scale production, Isoelectric point, 571 557 Isothiocyanates, 660 Off-gas analysis, |] Kinetics, 71, >2 21 i OOlni-gloilnyes inmee,a su6r8e9m ent, 473 SS.. aceurreevuiss iae6,2 8 252 Kluyveromyces marxianus, 53 Online monitoring, 381 Saccharomyces cerevisiae Operating conditions, 594 Schistosomiasis, 136 Large-scale, 681 Optical sensor, 473 Sensitivity analysis, 18, 285 Leishmanolysin, 407 Optimal control, 285 Sf-9 cells, 381 Leucine dehydrogenase, 557 Optimization, 218, 269 Shaking flasks, 589 Light regime, 173 Organic solvents, 339 Shaking flasks, modeling, 594 Lignin, 524 Oxidative stress, 389 Shear sensitivity of animal cells, 697 Lignocellulose, 524 Oxygen consumption, Simultaneous saccharification and Linear fusion, 211 Oxygen-dependent, 11 fermentation (SSF), 204 Lipase, 78, 84 Oxygen-enriched gas, Single-step modeling, 396 Lysozyme, 19] Softwood, 204 Solid-state fermentation, 127, 619 Packed-bed bioreactors, |27 Solubility, 279 Mammalian, 407 Parameter estimation, 422 Sparging, 328 Marine photosynthetic bacteria, 647 Penicillin-G, 602 Specific antibody productivity, 260 Mass transfer, 355 Penicillium chrysogenum, 602, 652 Specific production rate, 245 Mass transport, 536 Permeabilization, 430 Spinner cultivation, 59 Mathematical modeling, 18, Phaeodactylum tricornutum, 173 Sporulation, 11 Mathematical models, 308 Phagemid, 121 ST3Gal | inhibition, 239 Measuring method, 589 PHB metabolism, 496 Starch, 71, 269 Medium-chain-length Photoinhibition, 173 State estimation, 422 polyhydroxyalkanoates, 466 Physical properties, 218 Stereoselective hydrolysis, 78 MEL!I, 252 Pichia pastoris, 298 Stirred bioreactor, 59 Melibiose, 252 Plants, 52 Suspension cultures, 697 Melting of DNA, 339 Plasmid purification, 576 Symmetric branching model, 619 Membrane, 191 PLS, 473 Synthesis of acylglycerols, 563 Membrane-filter culture, 619 (poly esterification of glycerol, 563 Systemic lupus erythematosus, 571 Metabolic flux, 316 (poly )unsaturated fatty acids, 563 Metabolic flux analysis, 652 Polyethylenimine, 98 Metabolic flux manipulation, 602 Polymer chemistry, 665 ICA cycies 316 Metabolic model, 602 Polymer coating, 473 Termamyl”, 71 Metabolism, 308 Porous media, 536 lernary substrate system, 437 SUBJECT INDEX Thermostability, - 3] [rapped aqueous—organic biphase system, Viscosity, 681 Thermotolerant, 5 31 18 Viscous media, 594 Thermus thermophilus, 184 lrichloroethylene, 548 Volatile fatty acid, 269 Thin films, 488 Tubular photobioreactor, 173 Tissue engineering, heart physiology, 106 Wastewater treatment, 422 Toluene vapors, 448 Ultrafiltration, 191 Water addition, 448 lranscription, 260 Transfectoma, 260 Vanillyl alcohol, 524 Xylose, 524 Transfructosylation, 92 Vapor-phase bioreactors, 508 Translation, 260 Viologen electron carrier, | Yeast SUBJECT INDEX ™ =