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Biotechnology Bioengineering INDEX TO VOLUME 66 Biotechnology Bioengineering INDEX TO VOLUME 66 Biotechnology and —~ Bioengineering Editor Douglas S. Clark T Tenis Associate Editors Editorial Board lames D. Bryers Maria-Regina Kula Douglas IC iH eine Universitat Ly AA ldorf der KFA Harvey W. Blanch R. Lynd | rs lonathan S. Dordick Re) ns laer PDo,]l.y technic Ilnusctteitt ute lettrey A. Hubbell ETH—Ziirich and enetcteenatin: Testis of of Ziiri np ] 4 Founding Editor: Elmer L. Gaden Postmaster Advertising Sales Reprints Manuscripts Manuscripts All Other Correspondence Subscription Price | \ $4 Editorial Production, John Wiley Cr Inge address. For script f ries, p . ' *) This paper meets the requirement of ANSUVNISO Z39.48-1992 (Permanence of nail: SUBINFO@wiley con Paper) Biotechnology and Bioengineering Author Index to Volume 66 Abidi, N. See Noites, 1.S., 195 Hahn-Higerdal, B. See Planas, J., 211 Mensah, P. Agger, T. Harris, J.M. See Planas, J., 211 : Carta, G Adsorptive Control of Water Nielsen, J.: Genetically Structured Heijnen, J.J. See Schlatmann, J.E., 147 in Esterification with Immobilized Modeling of Protein Production in Heinzle, E. See Soda, S., 258 Enzymes. Continuous Operation in a Filamentous Fungi, 164 Hoffmann, F. See Schmidt, M., 61 Periodic Counter-Current Reactor, 137 Aires-Barros, M.R. See Carvalho, C.M.I Moliney, M. Imanishi, Y. See Kwon, O.H., 265 ; Wiechert, W.; Kownatzki, D.; de Graaf, Ingram, L.O. See Zaldivar, J., 203 \.A.: Bidirectional Reaction Steps in Irani, N. Metabolic Networks: IV. Optimal Bauer, M.W. See Driskill, L.E Wirth, M.; van den Heuvel, J.; Wagner, Design of Isotopomer Labeling Blayer, S. R.: Improvement of the Primary Experiments, 86 Woodley, J.M.; Dawson, M.J.; Lilly, Metabolism of Cell Cultures by : See Wiechert, W., 69 M.D.: Alkaline Biocatalysis for the Introducing a New Cytoplasmic Monteiro, G.A. Direct Synthesis of Pyruvate Carboxylase Reaction, 238 ; Ferreira, G.N.M.; Cabral, J.M.S..; N-Acetyl-p-Neuraminic Acid (Neu5Ac) Isermann, N. See Wiechert, W., 69 Prazeres, D.M.F Analysis and Use of from N-Acetyl-1 Glucosamine GleNAc), 131 Ito, Y. See Kwon, O.H., 265 Endogenous Nuclease Activities in Escherichia coli Lysates During the Johansson, H.-O. Primary Isolation of Plasmids for Gene abral, J.M.S. See Carvalho, C.M.L., 17 Therapy, 189 : Persson, J.: rjerneld, i See Monteiro, G.A., 189 Thermoseparating Water/Polymer Moreira, J.L. See Cruz, H.J., 104 ‘arrondo, M.J.T. See Cruz, H.J., 104 System: A Novel One-Polymer Aqueous ‘arta, G. See Mensah, P., 137 [Two-Phase System for Protein Nielsen, J. See Agger, T., 164 ‘arvalho, C.M.L. Purification, 247 Nienow, A.W. See Langheinrich, C., 171 Aires-Barros, M.R.; Cabral, J.M.S Noites, LS. Cutinase: From Molecular Level to Kang, K.A. See Spiker, J.O., 158 O’ Kennedy, R.D.; Levy, M.S.; Abidi, Bioprocess Development, 17 Kelly, R.M. See Driskill, L.E., 51 N.; Keshavarz-Moore, E.: Rapid Cole, J.A. See | loyd, 3 # 122 Keshavarz-Moore, E. See Noites, I.S., 195 Quantitation and Monitoring of Plasmid Constantinidis, I. See Papas, K.K., 219 Kim, D.-M. DNA Using an Ultrasensitive See Papas, K.K., 231 Swartz, J.R.: Prolonging Cell-Free DNA-Binding Dye, 195 Cruz, H.J. Protein Synthesis with a Novel ATP ; Moreira, J.L.; Carrondo, M.J.T Metabolic Shifts by Nutrient Regeneration System, 180 O’ Kennedy, R.D. See Noites, 1.S., 195 Kotter, P. See Flikweert, M.T., 42 Manipulation in Continuous Cultures of Kownatzki, D. See Méllney, M., 86 BHK Cells, 104 Papas, K.K. Kozlowski, A. See Planas, J., 21] ; Long, R.C., Jr.; Sambanis, A.; Kuyper, M. See Flikweert, M.T., 42 Constantinidis, I.: Development of a Dawson, M.J. See Blayer, S., 131 Kwon, O.H. de Graaf, A.A. See Mollney, M., 86 Imanishi, Y.; Ito, ¥ Catalytic Activity Bioartificial Pancreas: I. Long-Term Propagation and Basal and Induced See Wiechert, W., 69 and Conformation of Chemically Secretion from Entrapped BTC3 Cell Driskill, L.E. Modified Subtilisin Carlsberg in ; Bauer, M.W.; Kelly, R.M.: Synergistic Organic Media, 265 Cultures, 219 ; Long, R.C., Jr.; Sambanis, A.; Interactions Among $-laminarinase, Constantinidis, I.: Development of a 3-1,4-Glucanase, and B-Glucosidase Langheinrich, C. Bioartificial Pancreas: II. Effects of from the Hyperthermophilic Archaeon ; Nienow, A.W Control of pH in Pyrococcus furiosus During Hydrolysis Large-Scale, Free Suspension Animal Oxygen on Long-Term Entrapped BTC3 Cell Cultures, 231 of B-1.4-, B-1,3-, and Mixed-Linked Cell Bioreactors: Alkali Addition and Persson, J. See Johansson, H.-O., 247 Polysaccharides, 51 pH Excursions, 171 Planas, J. Levy, M.S. See Noites, I.S., 195 : Kozlowski, A.; Harris, J.M.; Tjerneld, Engasser, J.M. See Steward, N., 114 Lilly, M.D. See Blayer, S., 131 Lloyd, J.R. F.; Hahn-Hiagerdal, B.: Novel Polymer—Polymer Conjugates for ; Thomas, G.H.; Finlay, J.A.; Cole, J.A.; Ferreira, G.N.M. See Monteiro, G.A., 189 Macaskie, L.E.: Microbial Reduction of Recovery of Lactic Acid by Aqueous Two-Phase Extraction, 21] Finlay, Peo See Lloyd, J.R., 122 Technetium by Escherichia coli and Flikweert, M.T. Prazeres, D.M.F. See Monteiro, G.A., 189 Desulfovibrio desulfuricans ; Kuyper, M.; van Maris, A.J.A.; Kotter, Enhancement via the Use of Pronk, J.T. See Flikweert, M.T., 42 P.; van Dijken, J.P.; Pronk, J.T High-Activity Strains and Effect of Steady-State and Transient-State Process Parameters, 122 Ramirez, W.F. See Tholudur, A., | Analysis of Growth and Metabolite Long, R.C., Jr. See Papas, K.K., 219 Rinas, U. See Schmidt, M., 61 Production in a Saccharomyces ; See Papas, K.K., 231 cerevisiae Strain with Reduced Sambanis, A. See Papas, K.K., 219 Pyruvate-decarboxylase Activity, 42 Macaskie, L.E. See Lloyd, 5R... 122 ; See Papas, K.K., 231 Fujita, M. See Soda, S., 258 Marten, S. See Schmidt, M.. 61 Schlatmann, J.E. Martin, R. See Steward, N., 114 ; ten Hoopen, H.J.G.; Heijnen, J.J.: A Goergen, J.L. See Steward, N., 114 McMillan, J.D. See Thoiudur, A., | Simple Structured Model for Biotechnology and Bioengineering, Vol. 66, Pp. 276-277 (1999) Maintenance, Biomass Formation, and J.L.: Determination of Growth and Lysis Wagner, R. See Irani, N Ajmalicine Production by Nondividing Kinetics in Plant Cell Suspension Wiechert, W. Catharanthus roseus Cells, 147 Cultures from the Measurement of ; Mollney, M.; Isermann, N.; Wurzel, M Schmidt, M. Esterase Release, 114 de Graaf, A.A.: Bidirectional Reaction : Viaplana, E.; Hoffmann, F.; Marten, S.; Swartz, J.R. See Kim, D.-M., 180 Steps in Metabolic Networks: Ill Villaverde, A.; Rinas, | Explicit Solution and Analysis of Secretion-Dependent Proteolysis of Isotopomer Labeling Systems, 69 ten Hoopen, H.J.G. See Schlatmann, J.I Heterologous Protein by Recombinant - sce Mollney, M., 86 147 Escherichia coli ts Connected to an Wilson, D.B. See Zhang, S., 35 Tholudur, A. Increased Activity of the Wirth, M. See Irani, N., 238 Ramirez, W.F.; McMillan, J.D Energy-Generating Dissimilatory Wolfgang, D.E. See Zhang Ss ) Mathematical Modeling and Pathway, 61 Woodley, J.M. See Blayer, S., 131 Optimization of Cellulase Protein Soda, S. Wurzel, M. See Wiechert, W., 69 Production Using Trichoderma reesei ; Heinzle, E.; Fujita, M.: Modeling and RL-P37, | Simulation of Competition Between Zaldivar, J. Thomas, G.H. See Lloyd, J.R., 122 Two Microorganisms for a Single ; Ingram, L.O.: Effect of Organic Acids Tjerneld, F. See Planas, J., 211 Inhibitory Substrate in a Biofilm on the Growth and Fermentation of See Johansson, H.-O., 247 Reactor, 258 Ethanologenic Escherichia coli LYO| Spiker, J.O. 203 ; Kang, K.A.: Preliminary Study of van den Heuvel, J. See Irani, N., 238 Zhang, S. Real-Time Fiber Optic Based Protein C van Dijken, J.P. See Flikweert, M.T., 42 ; Wolfgang, D.E.; Wilson, D.B.: Substrate Biosensor, 158 van Maris, A.J.A. See Flikweert, M.T., 42 Heterogeneity Causes the Nonlinear Steward, N. Viaplana, E. See Schmidt, M., 61 Kinetics of Insoluble Cellulose ; Martin, R.; Engasser, J.M.; Goergen, Villaverde, A. See Schmidt, M.. 61 Hydrolysis, 35 AUTHOR INDEX Biotechnology and Bioengineering Subject Index to Volume 66 Fermentation, 203 Oscillations, 258 Ferulic acid, 203 Oxygen effects, 231 ATP) regeneration Fiber optics, 158 Fluid dynamics, 171 Packed-bed reactor, 137 Fluorescence, 195 Parameter function modeling, | Function, 17 Parameter identifiability, 69 Anim C Partitioning, 211 Anticoag Gene therapy, 189 pH excursions, 171 Aqueot GleNAc—ManNaAc epimerization, 131 Phosphoenol pyzuvate (PEP), 180 Asperg Glucose effects, 219 PicoGreen, 195 Glucose- and glutamine-uptake rates, 104 Plant cell culture, 147 Barle Glycolysis, 42 Plant cells, 114 Batch Glycosyl hydrolases, 51 Plasmid, 189 Plasmid DNA processing, 195 Hemicellulose, 203 Polyethylenimine, 211 Human lymphotoxin, 180 Polymer recycling, 247 4 hydroxybenzoic acid, 203 Production stage, 147 Hyperthermophilic, 51 Protein C, 158 Protein purification, 247 Immobilized cells, 122 Proteolytic degradation, 61 Immobilized enzymes, 137 Pyruvate, 42, 180 mmuno-optical detection, 158 Pyruvate carboxylase, 238 n vitro protein synthesis, 180 Pyruvate oxidase, 180 nhibition, 258 norganic phosphate, 180 Radionuclide bioaccumulation, 122 nsulin secretion, 219, 231 Recombinant protein, 61 isotopomer measurements, 50 Regulation, 42 otopomers. 69 Respiration, 42 RNA degradation, 189 Kinetic modeling RNase, 189 and ammonia-production rates, 104 Scale-up/scale-down, 171 Tide l i| l Stability, 17, 258 Storage carbohydrates, 147 Stress response, 61 Structure, 17 Structured model, 147 Mammalian cell Structured modeling, 164 Metabolic engineering Substrate heterogeneity, 35 Metabolic flux analysis, 69, 86 Subtilisin, 265 Metaboli optimization, 104 Sugar metabolism, 42 Metabolic shifts, 104 Sulfate-reducing bacteria Metal reduction, 12 Synergistic interaction, 51 Modified enzyme Syringic acid, 203 Multiple ste Multispecies model, Thermomonospora fusca, 35 Chermoseparating polymers, 24 Network analysis, 69 Trichoderma reesei. | Neural networks, | \ Nonlinear kinetics, 35 Nuclesapre ctrmoasgcnoeptyi,c 2r1e9s ona2n2c1e | NMR \Vi aibniilliltiyc , aci1d,1 4 203 ase. 189 Uptimal Organic acid, 203 Organic media, 265 Organ vents Biotechnology and Bioengineering, Vol. 66, P. 278 (1999)