Table Of Content

Biotechnology Bioengineering INDEX TO VOLUME 65 Biotechnology and —~ Bioengineering Editor Douglas S. Clark Engineering, Un Associate Editors Editorial Board Maria-Regina Kula James E. Bailey Douglas A. Lauffenburger h-Heine Univ ersitdat [ iirich Massachusetts Institute of Switzerland T echnole ly Crermany impr idge, Massa Harvey W. Blanch Universi ali Bernhard @ Palsson Jonathan S. Dordick Tadashi Matsunaga Troy, N Michael L. Shuler CU nievoerrgsei ty C,oefo rgiouTexas Cornell University Eleftherios | Papoutsakis } sity of Tok) Ithaca, New York Austin, Texa Northwestern University lettrey \. Hubbell Alexander M. Klibanov D. aniel I.C. Wang TH—Ziir ind John Villadsen Vass ICDUS ite of Massachusetts Institute Fou inding Editor: Elmer |! aden Postmaster: S D Advertising Sales S hn W W Reprints: R Der Manuscripts | ry S ¢ l , en I Manuscripts t CarlsCbA a92d00 8 All Other Correspondence: A lr ce D mn, Protes —— SCISEARCH Data x Medicus/MEDLINE Editorial Production, John Wiley Diane Gerr *) This paper meets the requirement of ANSI/NISO Z39.48-1992 (Permanence of Paper) Biotechnology and Bioengineering Author Index to Volume 65 Acuna, G. See Ferret, E., 512 Balance Modeling of Vanillin Chou, W.-C. Adams, M.W.W. See Kim, C., 108 Production from Vanillic Acid by ; Liao, K.-W.; Lo, Y.-C.; Jiang, S.Y.; Agarwal, P.K. Cultures of the Fungus Pycnoporus Yeh, M.Y.: Roffler, S.R Expression of ; Bhattacharya, S.K.: Construction of a cinnabarinus in Bioreactors, 558 Chimeric Monomer and Dimer Proteins Multi RE Module: Exploitation of Bernardes, E. See Diniz-Mendes, L., 572 on the Plasma Membrane of Mechanochemistry of Restriction Betenbaugh, M.J. See Mastrangelo, A.J., Mammalian Cells, 160 Endonucleases, 233 298 Christiansen, L.H. See Bocking, S.P., 638 Ageland, H. See Persson, J., 371 Bhattacharya, S.K. See Agarwal, P.K., 233 Chu, K.C. See Gordon, M.J., 459 Ahn, I.-S. Blanch, H.W. See Hickel, A., 425 Conradt, H.S. See Mueller, P.P., 529 ; Ghiorse, W.C.; Lion, L.W.; Shuler, Blomsten, G. See Schweder, T., 151 Conroy, M.J. See Gramer, M.J., 334 M.L.: Independent Prediction of Bocking, S.P. Courtois, J. See Harscoat, C., 500 Naphthalene Transport and ; Wiebe, M.G.; Robson, G.D.; Hansen, Cruces, M.A. See Ferrer, M., 10 Biodegradation in Soil with a K.; Christiansen, L.H.; Trinci, A.P.J.: Cruz, P.E. Mathematical Model, 65 Effect of Branch Frequency in ; Martins, P.C.; Alves, P.M.; Peixoto, Allinson, B.T. See Rodney, R.L., 485 Aspergillus oryzae on Protein Secretion C.C.; Santos, H.; Moreira, J.1 Alves, P.M. See Cruz, P.E., 133 and Culture Viscosity, 638 Carrondo, M.J.T Proteolytic Activity in Ameskamp, N. See Liitkemeyer, D., 114 Bogaert, H. See Yuan, Z., 265 Infected and Noninfected Insect Cells Amsden, B. Bouzerar, R. See Harscoat, C., 500 Degradation of HIV-1 Pr55gag Particles, 133 -; Turner, N.: Diffusion Characteristics of Boyle, J.D. See Stoodley, P., 83 Calcium Alginate Gels, 605 Brandt, S. Anderson, K.W. See Rao, S.V., 389 ; Zeng, A.-P.; Deckwer, W.-D Dalal, N.G. See Cha, H.J., 316 Andreopoulos, F.M. Adsorption Capacity as a Key Parameter Davis, G.D. ; Roberts, M.J.; Bentley, M.D.; Harris, for Enzyme Induction and ; Elisee, C.; Newham, D.M.; Harrison, J.M.; Beckman, E.J.; Russell, A.J.: Pentachlorophenol Degradation in R.G.: New Fusion Protein Systems Photoimmobilization of Mycobacterium chlorophenolicum Organophosphorus Hydrolase Within a PCP-1, 93 Designed to Give Soluble Expression in PEG-Based Hydrogel, 579 Breed, A.W. Escherichia coli, 382 de Araujo, P.S. See Diniz-Mendes, L., 572 Aratijo, E.F. See dos Santos, V.L., 673 ; Dempers, C.J.N.; Searby, G.E.; Gardner, Asami, K. See Higashiyama, K., 537 M.N.; Rawlings, D.E.; Hansford, G.S de Bang, H. See Santerre Henriksen, A.! Asselbergs, F.A.M. See Gandor, C.R., 523 The Effect of Temperature on the 76 de Barros, E.G. See dos Santos, V.L., 673 Asther, M. See Herpoél, I., 468 Continuous Ferrous-iron Oxidation De Bernardez Clark, E. See Lotwin, J., 437 ; See Bernard, O., 558 Kinetics of a Predominantly De Jesus, M. See Hunt, L., 201 Avraham, A. See Shpigel, E., 17 Leptospirillum ferrooxidans Culture, 44 de Maranon, I.M. Aziz, C.E. Butler, P.R. See Lane, P.G., 397 ; Chaudanson, N.; Joly, N.; Gervais, P ; Georgiou, G.; Speitel, G.E., Jr Cometabolism of Chlorinated Solvents Slow Heat Rate Increases Yeast Carlsen, M. See Santerre Henriksen, A.L., Thermotolerance by Maintaining Plasma and Binary Chlorinated Solvent Mixtures Using M. trichosporium OB3b 76 Membrane Integrity, 176 PP358, 100 Carrondo, M.J.T. See Cruz, P.E., 133 Deckwer, W.-D. See Brandt, S., 93 Carver, S.E. Dekel, M. See Shpigel, E., 17 ; Heath, C.A.: Influence of Intermittent DeLisa, M.P. Bachas, L.G. See Rao, S.V., 389 Pressure, Fluid Flow, and Mixing on the ; Li, J.; Rao, G.; Weigand, W.A.; Bailey, J.E. See Mazur, X., 144 Regenerative Properties of Articular Bentley, W.E.: Monitoring GFP-Operon : See Umaiia, P., 542 Chondrocytes, 274 Fusion Protein Expression During High ; See Hatzimanikatis, V., 631 Cayh, A. Cell Density Cultivation of Escherichia Ballesteros, A. See Ferrer, M., 10 ; Hirschmann, F.; Wirth, M.; Hauser, H.; coli Using an On-line Optical Sensor, 54 Bao, S. See Williams, A.R., 341 Wagner, R.: Cell Lines With Reduced Dempers, C.J.N. See Breed, A.W., 44 Barbotin, J.-N. See Mater, D.D.G., 3 UDP-N-Acetylhexosamine Pool in the Destruhaut, C. See Léonard, D., 407 Bassi, A.S. See Rowe, G.E., 613 Presence of Ammonium, 192 Devisscher, M. See Yuan, Z., 265 Bastin, G. See Bernard, O., 558 Cha, H.J. Dey, D. Beckman, E.J. See Rodney, R.L., 485 ; Dalal, N.G.; Pham, M.-Q.; Vakharia, ; Emery, A.N.: Problems in Predicting ; See Andreopoulos, F.M., 579 V.N.; Rao, G.; Bentley, W.E.: Insect Cell Damage From Bubble Bursting, Behie, L.A. See Kallos, M.S., 589 Larval Expression Process is Optimized 240 Belfort, G. See Luque, S., 247 by Generating Fusions with Green Diniz-Mendes, L. ; See Kluge, T., 649 Fluorescent Protein, 316 : Bernardes, E.; de Araujo, P.S.; Panek, Bennett, G.N. See Yang, Y.-T., 291 Chaudanson, N. See de Marafién, I.M., 176 A.D.; Paschoalin, V.M.F Preservation Bentley, M.D. See Andreopoulos, F.M.., Chen, C.-S. See Sarkari, M., 258 of Frozen Yeast Cells by Trehalose, 572 579 Chou, C.P. dos Santos, V.L. Bentley, W.E. See DeLisa, M.P., 54 ; Yu, C.-C.; Lin, W.-J.; Kuo, B.-Y.; ; Araujo, E.F.; de Barros, E.G.; —; See Cha, H.J., 316 Wang, W-C.: Novel Strategy for Guimaraes, W.V.: Fermentation of Bernabé, M. See Ferrer, M.. 10 Efficient Screening and Construction of Starch by Klebsiella oxytoca P2, Bernard, O. Host/Vector Systems to Overproduce Containing Plasmids with a-Amylase —: Bastin, G.; Stentelaire, C.; Penicillin Acylase in Escherichia coli, and Pullulanase Genes, 673 Lesage-Meessen, L.; Asther, M.: Mass 219 Dzengeleski, S. See Luque, S., 247 Biotechnology and Bioengineering, Vol. 66, Pp. 681-684 (1999) Efroni, G. See Harrison, R.G. See Davis, G.D., 382 ) Kasagi, H. See Kamiya, N., 227 Elisee, C. See Dav Harscoat, C. Kaufman, E.N. See Kim, C., 108 Emery, A.N. See Dey Jaffrin, M.Y Bouzerar, R.; Courtois, J Kellerhals, M.B. Enfors, S.-O. see Sc hweder Influence of Fermentation Conditions Kessler, B.; Witholt, B.: Closed-Loop Eppenberger, H.M. See Mazi and Microfiltration Processes on Control of Bacterial High-Cell-Density Eshel, A. See Shpigel, I Membrane Fouling During Recovery Fed-Batch Cultures: Production of Ethier, C.R. See Gordon Glucuronane Polysaccharides from mcl-PHAs by Pseudomonas putida Fermentation Broths, 506 KT2442 Under Single-Substrate and Ferrer, M. Harvey, L.M. See Wongwicharn, A., 416 Cofeeding Conditions, 306 Hatzimanikatis, V. Kessler, B. See Kellerhals, M.B., 306 Lee, K.H.; Bailey, J.E.: A Mathematical Kim, B.-G. See Shin, J.-S., 206 Description of Regulation of the GI-S Kim, C. Transition of the Mammalian Cell Woodward, C.A.; Kaufman, E.N.; Cycle, 631 Adams, M.W.W.: Stability and Hauser, H. See Cayli, A., 192 Sulfur-Reduction Activity in See Mueller, P.P., 529 Non-Aqueous Phase Liquids of the Heath, C.A. See Carver, S.! Hydrogenase from the Hecker, M. See Schweder, T Hyperthermophile Pyrococcus furiosus \pproach . Heijnen, J.J. See Lityjens, M.J.J 108 Flickinger, M.C. See Herpoél, I. Kim, H.K. Flor, P.J. See Gandor Asther, M.: Sigoillot, J.-( Park, T.G.: Microencapsulation of Fujikawa, S. See Higa Scale Up of a Process for Human Growth Hormone within Fussenegger, M. Se« Peroxidase Production Using Biodegradable Polyester Microspheres lypersecretory Strain Phanero Protein Aggregation Stability and Galban, C.J. hrysosporium 1-1512, 468 Incompiete Release Mechanism, 659 I ke Hickel, A. Kluge, T. Kine J.; Blanch, H.W Rezende, C.: Wood, D Belfort, G 1D ydroxynitrile Lyase at the Diisopropy! Protein Transmission During Dean ther/Water Interface: Evidence fo Vortex Microfiltration of Yeast M.O.: Flor nterfacial Enzyme Activity, 42 Suspensions, 649 ros. F.A.M.: ¢ nditionall Higashiyama, K. Knop, R.H. See Zanghi, J.A th of Serum-Independent Sugimoto, 1 Yonezawi Knutson, B.L. See Sarkari wr Automated Drug S.; Asami, K Dielectric Analysis for Kriiger, E. See Schweder, T and Biopharmaceutical Estimation of Oil Content in the Kula, M.-R. See Linden, 1 Pr tor 5s)? Mycelia of Mortierella alpi Kuo, B.-Y. See Chou, C.P Gardner, M.N. See Breed, A.W Hirschmann, F. See ¢ Kuriyel, R. See Luque, S., Gehlert, G. See Lug S Hunt, L. Kusunoki, K. See Kamiya Georgiou, G. See Az Jordan, M.: De Jesus, M Gervais, P. See de GFP-Expressing Mammalia Lan, Q. See Rowe, G.E., 613 Ghiorse, W.C. Sec Sensitive, Noninvasive Cell Lane, P.G. Giral, R. See Fe i Kinetic Oliver, S.G.; Butler, P.R Analysis of a Golden, J. S Continuous-Culture Technique for the Goldlust, A. Se« Shpige Selection of Mutants Tolerant to Gordon, M.J Iborra, J.L. See Lev Extreme Environmental Stress, 397 Chu, K.( Mar tis Martin, A.J Ingram, L.O. See Zaldiva Lappin-Scott, H.M. See Stoodley, P., 83 ier, C.R.:; Rutt, B.K.: Measurement Inoue, M. See Kamiya Lee, K.H. See Hatzimanikatis, V., 631 f Gd-DTPA Diffusion thi . Lee, S.Y. Hydrogel Using a Nove Jaffé, P.R. See Guha, S., 491 Lee, Y.: Wang, | Chiral Compounds Resonance Imaging Jaffrin, M.Y. See Harscoat, C., 500 from Bacterial Polyesters: Sugars to Goto, M. See Kamiva Jean-Mairet, J. See Umaiia, P., 542 Plastics to Fine Chemicals, 363 Gramer, M.J. Jiang, S.Y. See Chou, W.-( Lee, Y. See Lee, S.Y., 363 Poeschl, D.M.; Conroy, M.J Hammer, Joly, N. See de Marafion, I.M., 176 Lehmann, J. See Liitkemeyer, D., 114 3.E.: Effect of Harvestin Protocol on Jongejan, J.A. See Litjens, M.J.J Léonard, D. Performance of a Holl Jordan, M. See Hunt, L., 201 Youssef, C.B.; Destruhaut, C.; Lindley Bioreactor, 334 Jorquera, H. See Ferret, E., 512 N.D.; Queinnec, | Phenol Degradation Greenfield, P.F. See Zheng. Y.Z., 600 Jiirgen, B. See Schweder, T 1<S1I by Ralstonia eutropha: Colorimetric Guha, S. Jetermination of 2-Hydroxymuconate Peters, C.A Jaffe, P.R Multisubstrate Kallos, M.S. Semialdehyde Accumulation to Control Biodegradation Kinetics of Naphthalene Behie, L.A.; Vescovi, A. Extended Feed Strategy in Fed-Batch Phenanthrene, and Pyrene Mixtures, 491 Serial Passaging of Mammalian Neural Fermentations, 407 Guimaraes, W.V. See dos Santos, V.1 Stem Cells in Suspension Bioreactors, Lesage-Meessen, L. See Bernard, O., 558 6 S589 Levitsky, V.Y. Kamiya, N. Lozano, P.; Iborra, J.L.: Kinetic Hammer, B.E. See Gramer, M.J., 334 Kasagi, H.; Inoue, M.; Kusunoki, K Analysis of Deactivation of Immobilized Hansen, K. See Bocking, S.P., 638 Goto, M.: Enantioselective Recognition a-Chymotrypsin by Water-Miscible Hansford, G.S. See Breed, A.W., 44 Mechanism of Secondary Alcohol by Organic Sovent in Kyotorphin Hardwick, J.M. See Mastrangelo, A.J., 298 Surfactant-Coated Lipases in Synthesis, 170 Harris, J.M. See Andreopoulos, F.M., 579 Nonaqueous Media, 397 Lewandowski, Z. See Stoodley, P., 83 AUTHOR INDEX Li, x See DeLisa, M.P., 54 Fussenegger, M.: A Novel Radke, C.J. See Hickel, A., 425 Liao, K.-W. See Chou, W.-C., 160 Autoregulated Proliferation-Controlled Ramirez, M. Lin, W.-J. See Chou, C.P., 219 Production Process Using Recombinant Regodon, J.A.; Pérez, F.: Rebollo, J.t Linden, T. CHO Cells, 144 Wine Yeast Fermentation Vigor May Be ; Ljunglof, A.; Kula, M.-R.; Thommes, J MeNeil, B. See Wongwicharn, A., 416 Improved by Elimination of Recessi Visualizing Two-Component Protein Mendoza, T.P. See Zanghi, J.A., 182 Growth-Retarding Alleles, 212 Diffusion in Porous Adsorbents by Miller, D.L. See Williams, A.R., 341 Rao, G. See DeLisa, M.P., 54 Confocal Scanning Laser Microscopy, Miller, W.M. See Zanghi, J.A., 182 - See Cha, H.J., 316 622 Molin, P. See Ferret, E., 512 Rao, S.V. Lindley, N.D. See Léonard, D., 407 Moreira, J.L. See Cruz, P.t Anderson, K.W.: Bachas, L.G Lion, L.W. See Ahn, I.-S., 65 Mueller, P.P. Controlled Layer-By-Layet Litjens, M.J.J. ; Schlenke, P.; Nimtz, M.; Conradt, H.S.; Immobilization of Horseradish ; Sha, M.; Straathof, A.J.J.; Jongejan, Hauser, H.: Recombinant Glycoprotein Peroxidase, 389 J.A.: Heijnen, J.J Competitive Product Quality in Proliferation Rawlings, D.E. See Breed, A.W Lipase-Catalyzed Ester Hydrolysis and Controlled BHK-21 Cells, 529 Rebollo, J.E. See Ramirez, M., 212 Ammoniolysis in Organic Solvents; Mullick, A. Regodon, J.A. See Ramirez, M., 212 Equilibrium Model of a ; Flickinger, M.C Expanded Bed Reid, S. See Zheng, Y.Z., 600 Solid—Liquid—Vapor System, 347 Adsorption of Human Serum Albumin Rezende, C. See Kluge, T., 649 Lim, Y. from Very Dense Saccharomyces Rinzema, A. See Weber, F.J., 44 ; Model of Dissolved Organic Carbon cerevesiae Suspensions on Roberts, M.J. See Andreopoulos, F.M., 579 Distribution for Substrate-Sufficient Fluoride-Modified Zirconia, 282 Robson, G.D. See Bocking. S.P., 638 Continuous Culture, 474 Rodney, R.L. Ljunglof, A. See Linden, T., 622 Nakamura, N. See Okochi, M.. 480 Allinson, B.T.; Beckman, E.J.: Russell Lo, Y.-C. See Chou, W.-C., 160 \.J.: Enzyme-Catalyzed Nava Saucedo, J.E. See Mater, D.D.G Locke, B.R. See Galban, C.J., 121 Polycondensation Reactions for the Newham, D.M. See Davis, G.D., 382 Lotwin, J. Nielsen, J. See Santerre Henriksen, A. Synthesis of Aromatic Polycarbonates : De Bernardez Clark, I Oxidative 6 and Polyesters, 485 Renaturation of Hen Egg-White Nimtz, M. See Mueller, P.P., 529 Roffler, S.R. See Chou, W.-C Lysozyme in Polyethylene Glycol—Salt Nystrém, L. See Persson, J., 3 Roth, C.M. See Walton, S.P Aqueous Two-Phase Systems, 437 Rowe, G.E. Lozano, P. See Levitsky, V.Y., 170 ; Margaritis, A.; Lan, Q.; Bi Okochi, M. Luque, S. New Kinetic Model of Protein ; Mallubhotla, H.; Gehlert, G.; Kuriyel, ; Yokouchi, H.:; Nakamura, N Adsorption on Suspended R.; Dzengeleski, S.; Pearl, S.; Belfort, Matsunaga, 17 Electrochemical Anion-Exchange Resin Particles Detection of Allergen in Small-Volume G.: A New Coiled Hollow-Fiber Module Russell, A.J. See Rodney, R.L.. 485 Design for Enhanced Microfiltration Whole Blood | sing an Array See Andreopoulos, F.M., 579 Microelectrode: A Simple Method for Performance in Biotechnology, 247 Rutt, B.K. See Gordon, M.J., 459 Detection of Allergic Reaction, 480 Liitkemeyer, D. Oliver, S.G. See Lane, P.G., 397 LAemhemsaknanm,p , J N EstiTmeabbtei,o n H.o;f WCietltll er, J.: Orl: icShc,h omBa. ecker, R Enzymatic Reduction SSaann,t erKr.e- Y.H eSnerei ksYeann,g. AY..-LT.., 291 Damage in Bench- and Pilot-Scale Carlsen, M.: de Bang, H.: Nielsen Affinity Expanded-Bed Chromatography of a Less Water-Soluble Ketone in Kinetics of a-Amylase Secret Reverse Micelles with NADH for the Purification of Monoclonal Regeneration, 357 {spere is or rT, 16 Antibodies, 114 Santos, H. See Cruz, PI Sarkari, M. Mallubhotla, H. See Luque, S., 247 Palmer, R. See Uludag, H., 668 Knutson, B.L.: Chen, C.-S.: Enzymati Marangi, M. See Gandor, C.R., 523 Panek, A.D. See Diniz-Mendes, | Catalysis in Cosolvent Modified Margaritis, A. See Gordon, M.J., 459 Park, T.G. See Kim, H.K., 659 Pressurized Organic Solvents, 258 : See Rowe, G.E., 613 Paschoalin, V.M.F. See Diniz-Mendes, | Saville, B.A. See Warrington, J.¢ 32 Martin, A.J. See Gordon, M.J., 459 5 Schlenke, P. See Mueller, P.P., 529 Martinez, A. See Zaldivar, J., 24 Pearl, S. See Luque, S., 247 Schmelzer, A.E. See Zanghi, J.A Peixoto, C.C. See Cruz, P.E., 133 Martins, P.C. See Cruz, P.E., 133 Schomaecker, R. See Orlich, B Mastrangelo, A.J. Pérez, F. See Ramirez, M., 212 Schweder, T. Persson, J. ; Zou, S.; Hardwick, J.M.; Betenbaugh Kriiger, E.; Xu, B Jiirgen, B.: M.J.: Antiapoptosis Chemicals Prolong ; Nystrom, L.; Ageland, H.: Tjerneld, f Blomsten, G.; Enfors, $.-O Hecker Purification of Recombinant and Human Productive Lifetimes of Mammalian M.: Monitoring of Genes That Responc Cells upon Sindbis Virus Vector Apolipoprotein A-1 Using Surfactant to Process-Related Stress in Large-Scale Infection, 298 Micelles in Aqueous Two-Phase Bioprocesses, 151] Mater, D.D.G. Systems: Recycling of Searby, G.E. See Breed, A.W., 44 Nava Saucedo, J.E.; Truffaut, N Thermoseparating Polymer and Sha, M. See Litjens, M.J.J., 347 Surfactant with Temperature-Induced Barbotin, J.-N.; Thomas, D Shin, J.-S. Conjugative Plasmid Transfer Between Phase Separation, 371 : Kim, B.-G Asymmetric Synthesis of Pseudomonas Strains within Alginate Peters, C.A. See Guha, S., 491 Chiral Amines With w-Transaminase Bead Microcosms: Effect of the Internal Pham, M.-Q. See Cha, H.J., 316 206 Gel Structure, 34 Plou, F.J. See Ferrer, M., 10 Shoseyov, O. See Shpigel. f Matsunaga, T. See Okochi, M., 480 Poeschl, D.M. See Gramer, M.J., 334 Shpigel, E. Mazur, X. : Goldlust, A.; Efroni, G.; Avraham, A.: ; Eppenberger, H.M.; Bailey, J.E.; Queinnec, I. See Léonard, D., 407 Eshel, A.: Dekel, M.: Shoseyov, O AUTHOR INDEX Immobilization of Recombinant Verstraete, W. See Yuan, Z., 265 Yang, Y.-T. Heparinase I Fused to Cellulose-Binding Vescovi, A.L. See Kallos, M.S., 589 Bennett, G.N.; San, K.-Y.: Effect of Domain, | Inactivation of nuo and ackA-pta on Shuler, M.L. See Ahn, |.-S Wagner, R. See Cayli, A., 192 Redistribution of Metabolic Fluxes in Sigoillot, J.-C. See Herpoél Walton, S.P. Escherichia coli, 291 Siméon, J.H. See Ferret, I Stephanopoulos, G.N.:; Yarmush, M.I Yarmush, M.L. See Walton, S.P., | Speitel, G.E., Jr. See Aziz, ( 100 Roth, C.M Prediction of Antisense Yeh, M.Y. See Chou, W.-C... 160 Stentelaire, C. See Bernard, O., 558 Oligonucleotide Binding Affinity to a Yokouchi, H. See Okochi, M., 480 Stephanopoulos, G.N. See Walton, S.P Structured RNA Target Yonezawa, T. See Higashiyama, K., 53 Stoodley, P. Wang, F. See Lee, S.Y., 363 Youssef, C.B. See Léonard, D., 407 Wang, W-C. See Chou, ¢ , 219 Yu, C.-C. See Chou, C.P., 219 H.M.: Structural Warrington, J.C. Yuan, Z. of Bacterial Biofilms Saville, B.A Tyrosinase Inactivation in ; Bogaert, H.; Devisscher, M.; Short-Term Fluctuations 1n Organic Solvents, 325 Vanrolleghem, P.; Verstraete, W ud Shear: An In Situ Investigation of Weber, F.J. On-Line Estimation of the Maximum Biofilm Rheology, 83 lramper, J Rinzema, A \ Simplified Specific Growth Rate of Nitrifiers in Straathof, A.J.J. See Litjens, M.J.J., 34 Material and Energy Balance Approach Activated Sludge Systems, 265 Sugimoto, T. See Higashiyama, K., 537 for Process Development and Scale-Up of Coniothyrium minitans Conidia Zaldivar, J. Tebbe, H. See Liitkemever. D.. 114 Production by Solid-State Cultivation in ; Martinez, A.; Ingram, L.O.: Effect of Thomas, D. See Mater, D.D.G., 34 a Packed-Bed Reactor, 447 Selected Aldehydes on the Growth and rhémmes, J. See Linden, T., 622 Weigand, W.A. See DeLisa, M.P., 54 Fermentation of Ethanologenic litchener-Hooker, N.J. See Zhou, Y.H Wiebe, M.G. See Bocking, S.P., 638 Escherichia coli, 24 550 Williams, A.R. Zang-Gandor, M.O. See Gandor, C.R.., Ijerneld, F. See Persson, J., 371 Bao, S.; Miller, D.L.: Filtroporation Zanghi, J.A. lramper, J. See Weber, F.J., 447 le Technique for ; Schmelzer, A.E.; Mendoza, T.P.; Knop, rrinci, A.P.J. See Bocking, S.P., 638 Transfection and Macromolecular R.H.; Miller, W.M Bicarbonate lruffaut, N. See Mater, D.D.G., 34 Loading of Cells in Suspension, 341 Concentration and Osmolaiity Are Key rurner, N. See Amsden, B., 605 Wirth, M. See Cayli, A., 192 Determinants in the Inhibition of CHO Witholt, B. See Kellerhals, M.B., 306 Cell Polysialylation Under Elevated Uludag, H. Wittler, J. See Liittkemeyer, D., 114 pCO, or pH, 182 Golden, J.; Palmer, R.; Wozney, J.M Wonegwicharn, A. Zeng, A.-P. See Brandt, S., 93 tinated Bone Morphogenetic McNeil, B.; Harvey, L.M.: Effect of Zheng, Y.Z. n Vivo and In Vitro Oxygen Enrichment on Morphology Greenfield, P.F.; Reid, S.: Optimized Growth, and Heterologous Protein Production of Recombinant Bluetongue Umana, P. Production in Chemostat Cultures of Core-Like Particles Produced by the Je n M re Aspergillus niger B1-D, 416 Baculovirus Expression System, 600 Tetracycline-Regulated Overe xpression Wood, D. See Kluge, T., 649 Zhou, Y.H. t Giyce I *s in Chinese Woodward, C.A. See Kim, C., 108 ; Titchener-Hooker, N.J Visualizing Hamster Ovary lI 43 Wozney, J.M. See Uludag, H., 668 Integrated Bioprocess Designs Through Wurm, F.M. See Hunt, L., 201 “Windows of Operation”, 550 Vakharia, V.N. See Cha, H.J Zhu, J.-X. See Rowe, G.E., 613 Vanrolleghem, P. See Yuan Xu, B. Zou, S. See Mastrangelo, A.J., 298 AUTHOR INDEX Biotechnology and Bioengineering Subject Index to Volume 65 ackA-pta, 291 ‘ellulose-binding domain, 17 Escherichia coli, 24 Activated sludge, 265 ‘hemostat, 416 Ester ammoniolysis, Adsorption, 93, 613 ‘himeric proteins, 160 ster hydrolysis, 347 Affinity, | ‘hinese hamster ovary, 182 Stimation, e2e60 5 Aggregates, 589 ‘hinese hamster ovary (CHO), 201 thanol, 4JA Airlift bioreactor, 468 ‘hinese hamster ovary cells, 542 thanol production, 673 Alginate beads, 34 ‘hiral amine, 206 xopolysaccharides, 500 Alginate characteristic ratio, 605 hiral compound, 363 xpanded bed adsorption, 282 Ammonium, 192 ‘hirality, 363 xpanded-bed chromatography, | 14 Ammonium bicarbonate ‘hloramphenicol acetyl-transferase, 316 xpansion, 589 a-amylase, 76 ‘hloramphenicol acetyltransferase, 298 xtended culture, 589 Antibody production, 334 ‘hlorinated solvents, 100 Antisense, | ‘HO, 523 Antisense RNA inhibition, 192 hondrocytes, 274 Feasible space 550 Apolipoprotein A-1, 371 Fermentation, 24 ‘losed loop control, 306 Apoptosis, 298 O,, 182, 474 Fermentation vigor, 212 Aqueous, 437 ofactor regeneration, 357 Ferrous-iron oxidation kinetics, 44 Aqueous two-phase system, 37 Filamentous fungi, 558, 638 ‘ometabolism, 100 Aromatic diols, 485 Finite bath uptake, 622 ‘ompetitive inhibition, 49] Array microelectrode, 480 ‘onductivity of cytoplasm, 537 Fluorescence, 20] Arrhenius equation, 44 ‘onfocal microscopy, 622 Fluoride-modified zirconia, 282 Aspergillus niger, 416 Fouling, 83 oniothyrium minitans, 447 Aspe reillus orvzae. 76. 638 Freeze-drying, 57 ‘onjugative transfer, 34 Asymmetric synthesis, 206 Freezing, 572 ontinuous culture, 44, 397 Avidin, 389 Furfural, 24 ontinuous cultures, 34 Fusion protein, ‘ontrolled release, 659 Baby hamster kidney (BHK) cells, 529 onvection, 334 Baculovirus, 133, 316, 600 ore-like particles (CLP), 600 Gd-DTPA Bicarbonate, 182 osolvent effect, ) 258 Gene therapy, 341 Bingham fluid, 83 SLM, 622 Glucoamylase, 416, 638 Bioactivity, 668 ‘ycling, 334 Glucosamine-6-phosphate isomerase Biochemical applications, 459 Glycosylation engineering, 542 3iocontrol, 447 Glycosyltransferase, 542 Biodegradation kinetics, 491 Dean vortices, 247, 649 GPI anchor, 160 Biofilm, 83 Dense yeast suspensions Green fluorescent Biomass Dielectric analysis, 537 Biomedical, 459 Diffusion, 459, 6 >> Green fluorescent Bioprocess modeling, 550, 558 Diffusivity., 459 Growth, 474 Bioprocesses, 14 Dimer, 160 srowth-inhibition Bioreactor, 17, 151, 523 Dissolved oxygen, 416 srowth inhibitor, Bioremediation, 65 DOC distribution, 474 irowth limitateieo n, Biosensor, 480 Downstream processing, 371 srowth rate, 265 Biotechnology, 247 Dynamic filtration, 500 Biotin, 389 Haldane equation, Biotination, 668 E. coli, 291 Heat shock, 176 Biotransformations, 10 Heat transfer, 447 Bluetongue, 600 EE.f feccotl i ofl ystaetem,p er2a4t ure, 44 Helical hollow-fiber module, 247 Bone morphogenetic protein, 668 Electrochemical detection, 480 Hemicellulose, 24 BBoSvAi,n e 64s9e rum albumin (BSA), 613 i lectroporation, 34] Heterologous protein, 144, 416, 638 I nantioselectivity, 227 High cell density cultivation, 54 Bubble burst, 240 I‘ nergy uncoupling, 474 High-throughput screening, 523 Butyramide, 347 E nvironmental stress, 397 Highly branched mutants, 638 I nzymatic catalysis, 258 Hollow fiber bioreactor, 334 Cancer, 631 I nzyme, 485, 579 Horseradish peroxidase, 389 Carbon dioxide, 182 I nzyme catalysis, 35 Human growth hormone, 659 Cartilage, 274 Enzyme competition, 100 Human interleukin-2, 316 Cell confinement, 34 I nzyme deactivation, 17 Human serum albumin, 282 Cell culture, 182 I nzyme inactivation, 325 Hybridization, | Cell cycle, 631 I nzyme induction, 93 Hybridoma, 114, 334 Cell damage, 114, 240 I nzyme reaction, 227 Hydrogel, 605 Cell growth, 121, 201 I nzymes in organic solvents, 325 Hydrogels, 579 Cell volume, 176 I quilibrium model, 347 Hydrogenase, 108 Biotechnology and Bioengineering, Vol. 66, Pp. 685-687 (1999) -roteolytic degradation, 133 Pseudomonas, 34 RNA, 151 Pseudomonas putida, 65 ulti RE module Pulp and paper industry, 468 Multiplicity of infection, 600 Pulse-chase, 76 ultisubstrate. 491 Purification fermentation }2 Pycnoporus Pyrene, 49] Pyrococcus Ralstonia eutropha. 407 Random mutagenesis, 219 Nitrific 265 Recombinant human erythropoietin Nitrifiers. 265 glycosylation, 529 Non-aqueous solve | combinant protein, 219 wo, 291 cycling, 371 *dox potential 44 gioselectivity, 10 mote control, 306 *naturation, 437 s monitoring sidual substrate concentration, 474 tion. 600 Restriction endonucleases, 233 SOl ent, 22 Reverse micelles, 35 solvents, 17 Rheology, 83 (R)-(-)-hydroxycarboxy RNA folding, | RProtein A S° reduction, 108 entachlorophenol synthesis Shear stre equilibria, 34 Sialic acid Phenanthrene, 491 Simulation Phenol inhibition, 407 Sindbis virus Sinorhizobium meliloti. 500 Pilot scale Solid-state cultivation, 44 LGA. 659 Solid-state fermentation, 512 Polycarbonates, 4 Soluble protein expression, 382 Solute diffusivity, 605 Starch fermentation, 673 Strree ss giee nes,> 11s5]1 Stress response lroxyalkanoate (PHA 363 Su » 55 iroxvalkanoates. 30¢ Substrate inhibition, 389 tlexibilitv. 605 Substrate-sufficient culture, 474 rization. 485 Sucrose, 10 yphenol oxidase, 32 Sucrose esters. 10 lvsialvlation ‘rcritical fluids, 258 face expression, 160 face properties, 240 Surfactant, 3 ressul 274 Surta Pressurized organic s t uspension bioreactor, 589 Product inhibition. 206 Syringaldehyde, 24 Product removal, 206 Proliferation, 144 lemperature, 176 Proliferation control, 529 etracycline-regulated expression Protein, 613 rhermoseparating polymer, 371 roscopi 2 in adsorption, 622 Thickness, 83 Microspheres Protein aggregation stability, 659 ip diffusion, 512 Minimum inhibitory concentration, 21‘ *in-free, 523 issue, 274 Mixin | in glycosylation, 192 issue engineering, Modeling, 7 13 1 secretion, 76 -transaminase, 206 Monod kineti 19 | ? transmission, 649 Transfection, 34] SUBJECT INDEX Transmembrane domain, 160 Viability, 176 Whole-cell reaction, 206 Tlrriechhaloopsleu,s ia5 e77425n i, 316 VViissccooseiltays,t ic6y3,8 83 WWiinned owqsua litofy op4e1r9a tion, 550 Two-phase, 437 Vitronectin, 523 I'wo-phase system, 425 Volume averaging, 121 Xyl Tyrosinase, 325 Water activity, 258, 447 Yeast, 212 Vanillic acid, 558 Western blotting, 600 Yeast cells, 572 Vanillin, 24, 558 Whole blood, 480 Yeast suspension, 2 SUBJECT INDEX