Table Of Content

Detoxification of Organophosphate Pesticides Using an Immobilized Phosphotriesterase from Pseudomonas diminuta S. R. Caldwell and F. M. Raushel Continuous Cell Suspension Processing Using Magnetically Stabilized Fluidized Beds B. E. Terranova and M. A. Burns Crossflow Microfiltration of Animal Cells B. Maiorella, G. Dorin, A. Carion, and D. Harano A Simple Model to Describe Transient Differences Between Cell Number and Biomass Growth Rates of Escherichia coli J. B. Rodin, G. K. Lybertos, and §. A. Svoronos Lewis Cell Studies to Determine Reactor Design Data for Two-Liquid-Phase Bacterial and Enzymic Reactions J. M. Woodley, A.J . Brazier, and M. D. Lilly NADH Fluorescence and Oxygen Uptake Responses of Hybridoma Cultures to Substrate Pulse and Step Changes S.A. Siano and R. Mutharasan Modeling of Enzyme-Potentiometric Sensors Involving Acid- or Base-Forming Reactions S.O. Ogundiran, S. Varanasi, and E. Ruckenstein Moisture-Induced Aggregation of Lyophilized Proteins in the Solid State W.R. Liu, R. Langer, and A. M. Klibanov A New Method for Direct Selection of Plasmid-Free Segregants Using Mercury Hypersensitivity as a Phenotypic Marker of Bacterial Plasmids T. Mori, T. Kaga, K. Toda, H. Nakahara, H. Ohtake Communication to the Editor 190 Quantitative Evaluation of the pH Profile in Organic Acid Fermentations D.G. Hatzinikolaou and H.Y. Wang February 1991 February 5, 1991 197 Thermodynamic Evaluation of Energy Metabolism in Mixed Substrate Catabolism: Modeling Studies of Stationary and Oscillatory States M.A. Aon and S. Cortassa Mass Transfer Characterization of an Airlift Probe for Oxygenating and Mixing Cell Suspensions in an NMR Spectrometer H.W. Kramer and J. E. Bailey A Structured Model for Monoclonal Antibody Synthesis in Exponentially Growing and Stationary Phase Hybridoma Cells T. Bibila and M.C. Flickinger An Approach for the Stable Immobilization of Proteins D. Leckband and R. Langer Factors Influencing Recombinant Protein Yields in an Insect Cell-Baculovirus Expression System: Multiplicity of Infection and Intracellular Protein Degradation P. Licari and J. E. Bailey Continuous Anaerobic Treatment of Autoxidized Bark Extracts in Laboratory-Scale Columns J. Field, M.J . H. Leyendeckers, R. Sierra-Alvarez, G. Lettinga, and L. H. A. Habets Comparative Studies of Physiological and Environmental Effects on the Production of Cyclosporin A in Suspended and Immobilized Cells of Tolypocladium inflatum G.-T. Chun and S. N. Agathos 266 Recovery of Copper and Cobalt by Biopolymer Gels L. K. Jang, S. L. Lopez, S. L. Eastman, and P. Pryfogle 274 The Interaction of Xylanases with Commercial Pulps D. J. Senior, P.R. Mayers, and J. N. Saddler 280 Protein Adsorption and Leakage in Carrier-Enzyme Systems R. Ulbrich, R. Golbik, and A. Schellenberger Communications to the Editor 288 Analysis of Dispersion Structure of Fermentation Media by Dynamic Gas Disengagement Method Y.H . Lee, Y.J . Kim, and C. B. Weinberger 292 The Influence of Temperature on a Mouse—Mouse Hybridoma Growth and Monoclonal Antibody Production G. K. Sureshkumar and R. Mutharasan February 20, 1991 297 Two-Stage Fermentation with Bacteriophage A as an Expression Vector in Escherichia coli T. H. Park, J.-H. Seo, and H.C. Lim 303 Activity and Flexibility of Alcohol Dehydrogenase in Organic Solvents R. M. Guinn, P.S. Skerker, P. Kavanaugh, and D. S. Clark 309 Influence of Dilution Rate and Induction of Cloned Gene Expression in Continuous Fermentations of Recombinant Yeast N.A. Da Silva and J. E. Bailey Influence of Plasmid Origin and Promoter Strength in Fermentations of Recombinant Yeast N.A. Da Silva and J. E. Bailey Plasmid Maintenance and Protein Overproduction in Selective Recycle Bioreactors K. L. Ogden and R. H. Davis Calculations of the Heart of Growth of Escherichia coli K-12 on Succinic Acid E. H. Battley Performance of the Anaerobic Baffled Reactor under Steady State and Shock Loading Conditions A. Grobicki and D.C. Stuckey Ion Exchange and Affinity Chromatography in the Scaleup of the Purification of a-Galactosidase from Soybean Seeds J. E. Porter, M. R. Ladisch, and K. M. Herrmann An Investigation into the Role of Initial K,a on the Growth and Alkaloid Accumulation by Cultures of Catharanthus roseus F. Leckie, A. H. Scragg, and K.C. Cliffe Communications to the Editor 371 Effect of Agitational Shear on Growth and Protease Production by Thermomonospora fusca T.W. Gusek, R. D. Johnson, M.T. Tyn, and J. E. Kinsella A Kinetic Model for Methanogenesis from Whey Permeate in a Packed Bed Immobilized Cell Bioreactor S-T. Yang and M. Guo Analysis of Polymer Synthesis Rates During Steady-State Growth of X. campestris O. Vashitz and M. Sheintuch Minimizing the Errers Associated with the Determination of Effective Diffusion Coefficients when Using Spherical Cell Immobilization Matrices J.N. Petersen, B. H. Davidson, and C. D. Scott Effect of Continued Exposition to Ethanol on Activity of the Ammonium and Fructose Transport Systems in Saccharomyces cerevisiae R. Iglesias, J. M. Ferreras, F. J. Arias, R. Munoz, and T. Girbés Uncatalyzed Oxidation of Aqueous Sodium Sulfite and Its Ability to Simulate Bacterial Respiration P.K. Hui and H. J. Palmer March 1991 March 5, 1991 397 Plant Cell Bioreactor for the Production of Protoberberine Alkaloids from Immobilized Thalictrum rugosum Cultures P. J. Facchini and F. DiCosmo Determination of Kinetic Parameters Related to the Plasmid Instability: For the Recombinant Fermentation under Repressed Condition S. H. Park, D. DY. Ryu, and S. B. Lee Recombinant Protein Synthesis and Plasmid Instability in Continuous Cultures of Escherichia coli JM103 Harboring a High Copy Number Plasmid W. Ryan and S. J. Parulekar Recombinant Protein Excretion in Esherichia coli JM103[pUC8]: Effects of Plasmid Content, Ethylenediaminetetraacetate, and Phenethyl Alcohol on Cell Membrane Permeability W. Ryan and S. J. Parulekar Uptake of Cadmium and Zinc by the Alga Chlorella vulgaris: I1. Multi-Ion Situation Y. P. Ting, F. Lawson, I.G. Prince Morphology and Clavulanic Acid Production of Streptomyces clavuligerus: Effect of Stirrer Speed in Batch Fermentations M.T. Belmar-Beiny and C. R. Thomas In Situ Recalibration of Probes of Dissolved Gas Concentrations in Bioreactors without Effect on Metabolism and Growth J.J. L. Iversen A Parametric Study of Protease Production in Batch and Fed-Batch Cultures of Bacillus firmus S.-H. Moon and S. J. Parulekar Lethal Events during Gas Sparging in Animal Cell Culture I. Jobses, D. Martens, and J. Tramper The Effect of an Applied Potential on the Activity of Carbonic Anhydrase Immobilized on Graphite Rods K.L. McLachlan and A. L. Crumbliss 1991 Oxidation of Hydrogen Sulfide by Flocculated Thiobaccillus denitrificans in a Continuous Culture C. Ongcharit, K. L. Sublette, and Y.T. Shah Effect of the Interfacial Surfactant Layer on Oxygen Transfer through the Oil/Water Phase Boundary in Perfluorocarbon Emulsions L.-K. Ju, J. F. Lee, and W. B. Armiger Development of Pure Culture Biofilms of P. putida on Solid Supports G.S. Shreve, R. H. Olsen, and T. M. Vogel Papain in Organic Solvents: Determination of Conditions Suitable for Biocatalysis and the Effect on Substrate Specificity and Inhibition D. E. Stevenson and A.C. Storer Growth and Fermentation Characteristics of New Sclected Strains of Saccharomyces at High Temperatures and High Cell Densities C. Laluce, M.C. Palmieri, and R.C. Lopes da Cruz Absorption of y-Globulin, a Model Protein for Antibody, on Colloidal Particles A. Kondo, S. Oku, and K. Higashitani Analysis of Mass Transfer for Immobilized Cells in an Extractive Lactic Acid Fermentation V. M. Yabannavar and D. I.C. Wang Methanol Biosynthesis by Covalently Immobilized Cells of Methylosinus trichosporium: Batch and Continuous Studies P. K. Mehta, S. Mishra, and T. K. Ghose Effect of Operating Variables on Biofilm Formation and Performance of an Anaerobic Fluidized-Bed Bioreactor T. R. Sreekrishnan, K. B. Ramachandran, and P. Ghosh Kinetics and Modeling of Temperature Effects on Batch Xanthan Gum Fermentation C.-H. Shu and S.-T. Yang Hydrolysis of Inulin: A Kinetic Study of the Reaction Catalyzed by an Inulinase from Aspergillus ficuum P. Carniti, P. L. Beltrame, D. Guardione, B. Focher, and A. Marzetti Promotion of Oxygen Transfer in Three-Phase Fluidized-Bed Bioreactors by Floating Bubble Breakers Y. Kang, L.T. Fan, B.T. Min, and S. D. Kim Communications to the Editor 587 Fermentation of Lactose to Ethanol with Recombinant Yeast in an Immobilized Yeast Membrane Bioreactor Y. S. Jeong, W.R. Vieth, and T. Matsuura The Effect of Dissolved Oxygen and Aeration Rate on Antibiotic Production of Streptomyces fradiae H.C. Chen and F. Wilde 1991 Adaptive Control of Dissolved Oxygen Concentration in a Bioreactor S.C. Lee, Y.B . Hwang, H. N. Chang, and Y. K. Chang The Effect of Pore-Size Distribution on the Binding of Proteins to Porous Resin Beads M. Hasegawa and H. Kitano A Novel Magnetic Silica Support for Use in Chromatographic and Enzymatic Bioprocessing V. Goetz, M. Remaud, and D. J. Graves A Three-Dimensional Solubility Parameter Approach to Nonaqueous Enzymology L.V. Schneider Enzymatic Synthesis of a Sucrose-Containing Linear Polyester in Nearly Anhydrous Organic Media D.F. Patil, D.G. Rethwisch, and J. S§. Dordick Measurement of Bacterial Random Motility and Chemotaxis Coefficients: I. Stopped-Flow Diffusion Chamber Assay R. M. Ford, B. R. Phillips, J.A . Quinn, and D. A. Lauffenburger Measurement of Bacterial Random Motility and Chemotaxis Coefficients: II. Application of Single-Cell-Based Mathematical Model R. M. Ford and D. A. Lauffenburger Studies on the Optimization of Growth and Indole Alkaloid Production by Hairy Root Cultures of Catharanthus roseus L. Toivonen, M. Ojala, and V. Kauppinen A Dispersion Model for Predicting the Extent of Starch Liquefaction by Bacillus licheniformis a-Amylase during Reactive Extrusion V. Komolprasert and R.Y. Ofoli Communications to the Editor 691 On the Estimation of Average Shear Rate in Bubble Columns M. Nishikawa A New Procedure for Enzymatic Semisynthesis of Human Insulin by Hydrolysis of Single-Chain Des-(B-30)-Insulin Precursor with Lysyl Endopeptidase K. Morihara and Y. Ueno Erratum April 1991 April 5, 1991 697 Flocculation of Cell Debris from Ultrasonicated Escherichia coli E. Gellan, G. F. Martin, and R. H. Cumming 703 The Production of the Enzyme Dextransucrase Using Nonaerated Fermentation Techniques P. E. Barker and N. J. Ajongwen Prediction of Effects of Amino Acid Supplementation on Growth of E. coli B/r J. Shu and M. L. Shuler Strategies for Reducing Solvent Toxicity in Extractive Fermentations V. M. Yabannavar and D.1.C. Wang Translation of Immobilized Genetic Information by Yeast Cell-Free Protein Synthesizing System E. Kobatake, Y. Ikariyama, and M. Aizawa Retention of Enzyme by Electropolymerized Film: A New Approach in Developing a Hypoxanthine Biosensor A.-L. Nguyen, J.H.T. Luong, and A. M. Yacynych Plasmid Presence Changes the Relative Levels of Many Host Cell Proteins and Ribosome Components in Recombinant Escherichia coli S. Birnbaum and J. E. Bailey High-Concentration Cultivation of Lactococcus cremoris in a Cell-Recycle Reactor B. Bibal, Y. Vayssier, G. Goma, and A. Pareilleux A Fiber-Bed Bioreactor for Anchorage-Dependent Animal Cell Cultures: Part I. Bioreactor Design and Operations T.-W. Chiou, S. Murakami, D.I.C. Wang, and W.-T. Wu A Fiber-Bed Bioreactor for Anchorage-Dependent Animal Cell Cultures: Part II. Scaleup Potential S. Murakami, T.-W. Chiou, and D.I.C. Wang Affinity Chromatography as a Rapid and Convenient Method for Purification of Fungal Laccases J. Rogalski, M. Wojtas-Wasilewska, R. Apalovic, and A. Leonowicz Observations of Binary Population Biofilms M. A. Siebel and W.G. Characklis A Production of Monoclonal Antibodies by a Simple Electrofusion Technique Induced by AC Pulses Y. Takahashi, K. Suzuki, T. Niimura, T. Kano, and S. Takashima April 15, 1991 795 Enzymatic Production of Cyclodextrins from Unliquefied Corn Starch in an Attrition Bioreactor Y.-D. Lee and H.-S. Kim Modeling Fermentations with Recombinant Microorganisms: Formulation of a Structured Model J. Nielsen, A.G. Pedersen, K. Strudsholm, and J. Villadsen Reaction Characteristics and Stability of a Membrane-Bound Enzyme Reconstituted in Bilayers of Liposomes A. Kheirolomoom, S. Katoh, E. Sada, and K.-i. Yoshida Optimal Nonsingular Control of Fed-Batch Fermentation Z. Kurtanjek Characterization of Immobilized Cell Growth Rates Using Autoradiography P.S. Stewart, S. F. Karel, and C. R. Robertson Absorption of CO; in Algal Mass Culture Systems: A Different Characterization Approach P. Talbot, M. P. Gortares, R.W. Lencki, and J. de la Noiie Enzyme Thermoinactivation in Anhydrous Organic Solvents D. B. Volkin, A. Staubli, R. Langer, A. M. Klibanov Characterization of the Biochemical Behavior of Glucose Oxidase Entrapped in a Polypyrrole Film G. Fortier and D. Bélanger Calcium and Phosphate Effects on Growth and Aikaloid Production in Coffea arabica: Experimental Results and Mathematical Model J. L. Bramble, D. J. Graves, and P. Brodelius Optimization of Pro-Urokinase Secretion from Recombinant Saccharomyces cerevisiae B.G. Turner, G.C. Avgerinos, L. M. Melnick, and D.T. Moir Enzymatic Cellulose Hydrolysis in an Attrition Bioreactor Combined with an Aqueous Two-Phase System F. Tjerneld, I. Persson, and J. M. Lee Communications to the Editor 883 Enzymatic Syntheses of Alkyds. II: Lipase-Catalyzed Polytransesterification of Dichloroethyl Fumarate with Aliphatic and Aromatic Diols S. Geresh and Y. Gilboa 889 Measuring k,a with Randomly Pulsed Dynamic Method L. Gauthier, J. Thibault, and A. LeDuy April 25, 1991 895 Complex Growth Dynamics in Batch Cultures: Experiments and Cybernetic Models JV. Straight and D. Ramkrishna 910 Characterization of a Pilot Plant Airlift Tower Loop Bioreactor: II. Evaluation of Global Mixing Properties of the Gas Phase During Yeast Cultivation S. Frohlich, M. Lotz, T. Korte, A. Liibbert, K. Schiigerl, and M. Seekamp Photosynthetic Activity of Plant Cells Solubilized in Water-in-Oil Microemulsions A. Hochkoeppler and P. L. Luisi Transient Response Method for Evaluating the Rate Constants of Reactions over Immobilized Enzymes J.-Y. Wu and H.-S. Weng Kinetics of Loss of a Recombinant Plasmid in Bacillus subtilis Y. Shoham and A. L. Demain A Study of the Energetics and Economics of Microalgal Mass Culture with the Marine Chlorophyte Tetraselmis suecica: Implications for Use of Power Plant Stack Gases E. A. Laws and J. L. Berning Semicontinuous Enzymatic Hydrolysis of Lignocelluloses M. Ishihara, S. Uemura, N. Hayashi, and K. Shimizu Flotation of Streptomyces pilosus after Lead Accumulation Z. Sadowski, Z. Golab, and R.W. Smith 960 Oxygen Transfer in Slurry Bioreactors Y. Kawase and M. Moo-Young 967 Papain Kinetics in the Presence of a Water-Miscible Organic Solvent M.N. Fernandez, D.S. Clark, and H.W. Blanch 973 Growth, Death, and Oxygen Uptake Kinetics of Pichia stipitis on Xylose P.J . Slininger, L. E. Branstrator, R.J . Bothast, M. R. Okos, and M. R. Ladisch Communications to the Editor 981 Comments on a Segregated Model of Recombinant Cultures L. Cazzador 985 Rate Equations for the Vigorous Stationary Phase Fermentation of Citric Acid by Saccharomycopsis lipolytica E. K. Kim and R. S. Roberts Effect of Medium Osmolarity on Hybridoma Growth, Metabolism, and Antibody Production S. S. Ozturk and B.O. Palsson May 1991 Elmer L. Gaden, Jr., Father of Biochemical Engineering A. E. Humphrey Ultrasound-Enhanced Bioprocess. II: Dehydrogenation of Hydrocortisone by Arthrobacter simplex M. Zabaneh and R. Bar Enzymatic Synthesis of Esters Using an Immobilized Lipase G. Carta, J.L. Gainer, and A. H. Benton Periodic Operation of Immobilized Live Cell Bioreactor for the Production of Candicidin A. Constantinides and N. Mehta High Gradient Magnetic Separation of Yeast R.R. Dauer and E. H. Dunlop Increased Protein Productivity from Immobilized Recombinant Yeast E. L. Walls and J. L. Gainer The Biodegradation of Mixtures of Organic Solvents by Mixed and Monocultures of Bacteria U. Bitzi, T. Egli, and G. Hamer Use of Fluorometry for Monitoring and Control of a Bioreactor J.-k. Li and A. E. Humphrey Oxygen Uptake by Entrapped Hybridoma Cells D. Wohlpart, J. Gainer, and D. Kirwan Tubular Bioreactors: Case Study of Bioreactor Performance for Industrial Production and Scientific Research A. Moser A Molecular Model for Singlet/Singlet Energy Transfer of Monovalent Ligand/Receptor Interactions D. L. Meadows and J. S. Schultz Kinetic Analysis of the Effects of Plasmid Multimerization on Segregational Instability of ColE1 Type Plasmids in Escherichia coli B/r B.G. Kim and M. L. Shuler Optimization of Batch Processes Involving Simultaneous Enzymatic and Microbial Reactions J. A. Asenjo, W.-H. Sun, and J. L. Spencer Extractive Fermentation for Lactic Acid Production V. M. Yabannavar and D.1I.C. Wang Development of a Large-Scale Continuous Substrate Feed Process for the Biotransformation of Simvastatin by Nocardia s.p. K. Gbewonyo, B.C. Buckland, and M. D. Lilly Optimization of t-Malic Acid Production by Aspergillus flavus in a Stirred Fermentor E. Battat, Y. Peleg, A. Bercovitz, J.S. Rokem, and I. Goldberg June 1991 June 5, 1991 1 Structured Modeling of a Microbial System: I. A Theoretical Study of Lactic Acid Fermentation J. Nielsen, K. Nikolajsen, and J. Villadsen Structured Modeling of a Microbial System: II. Experimental Verification of a Structured Lactic Acid Fermentation Model J. Nielsen, K. Nikolajsen, and J. Villadsen Structured Modeling of a Microbial System: III. Growth on Mixed Substrates K. Nikolajsen, J. Nielsen, and J. Villadsen Lipase-Catalyzed Hydrolysis of 2-Naphtyl Esters in Biphasic System Y. Miyake, M. Ohkubo, and M. Teramoto Mass Production of Human Epidermal Growth Factor Using Fed-Batch Cultures of Recombinant Escherichia coli N. Shimizu, S. Fukuzono, Y. Harada, K. Fugimori, K. Gotah, and Y. Yamazaki Characterization of a Pilot Plant Airlift Tower Loop Bioreactor. I: Evaluation of the Phase Properties with Model Media S. Fréhlich, M. Lotz, T. Korte, A. Liibbert, K. Schiigerl, and M. Seekamp Characterization of a Pilot Plant Airlift Tower Loop Reactor: III. Evaluation of Local Properties of the Dispersed Gas Phase During Yeast Cultivation and in Model Media S. Frohlich, M. Lotz, B. Larson, A. Liibbert, K. Schiigerl, and M. Seekamp Modeling Growth and Succinoglucan Production by Agrobacterium radiobacter NCIB 9042 in Batch Cultures C.G. Dussap, C. De Vita, and A. Pons Dilution Rate as a Determinant of Mycelial Morphology in Continuous Culture M.G. Wiebe and A. P.J . Trinci Cleaning of Inorganic Membranes after Whey and Milk Ultrafiltration G. Daufin, U. Merin, J. P. Labbé, A. Quemerais, and F. L. Kerhervé Influence of pH, Temperature, and Inoculum Composition on Mixed Cultures of Streptococcus thermophilus 404 and Lactobacillus bulgaricus 398 C. Beal and G. Corrieu Development of Biosensors for the Simultaneous Determination of Sucrose and Glucose, Lactose and Glucose, and Starch and Glucose E. Watanabe, M. Takagi, S. Takei, M. Hoshi, and C. Shu-gui Communications to the Editor 104 Protease-Catalyzed Peptide Synthesis Using Inverse Substrates: The Influence of Reaction Conditions on the Trypsin Acyl Transfer Efficiency V. Schellenberger, H.-D. Jakubke, N. P. Zapevalova, and Y. V. Mitin June 20, 1991 109 Relative Contributions of Biological and Chemical Reactions to the Overall Rate of Pyrite Oxidation at Temperatures between 30°C and 70°C F.C. Boogerd, C. van den Beemd, T. Stoelwinder, P. Bos, and J.G. Kuenen Kinetic Data for the BM-5 Insect Cell Line in Repeated-Batch Suspension Cultures D. A. Stavroulakis, N. Kalogerakis, L. A. Behie, and K. Iatrou a-Amylase Adsorption on Starch Crystallites V. M. Leloup, P. Colonna, and S.G. Ring Enzymic Hydrolysis of Lignocellulosic Materials: I. Models for the Hydrolysis Process— A Theoretical Study L. Vallander and K.-E. L. Eriksson