Bio/Technology 1994: Vol 12 Index

13 Pages·1994·4.2 MB·English

Volume 12 1994 index Brings in $1.6 billion seaJurliacn Phére)z-P,ére z,
(News), B.J. Spalding Gabriel Marquez, José-Luis
Table Of Contents 1994 Will See Stocks Trade Barbero, Julio Gutiérrez
on Own Merits (News), R. Rapid Selection Using
Brandon Fradd G418 of High Copy Num-
The Dramatic Fall and Rise ber Transformants ofPichia
of Agracetus (News), pastoris for High-level For-
January Microinjection (Research), George Kidd eign Gene Expression (Re-
Not Science, but Necessary Jamie Love, Clare Gribbin, Nycomed Pharma Laun- search), Carol A. Scorer,
(Editorial), Susan Hassler Christine Mather, Helen ches Surgical Bandage Jeffrey J. Clare, William R.
Perpetual Rumination (Edi- Sang (News), Gerard O’ Dwyer McCombie, Michael A.
torial), Bernard Dixon Improvement of Ornamen- Drug Companies Must Be- Romanos, Koti Sreekrishna
FDA Panel Nixes Medim- tal Characters and Fra- friend Managed Care High Yield Production and
mune’s Respigam (News), grance Production in (News), B.J. Spalding Purification of Recombi-
Jeffrey L. Fox Lemon-scented Geranium Do Transgenic Crops Pose nant Staphylokinase for
Corange Sinks $206 Mil- Through Genetic Transfor- Ecological Risks? (News), Thrombolytic Therapy (Re-
lion into PDL (News), B.J. mation by Agrobacterium Jeffrey L. Fox search), Bernhard Schlott,
Spalding rhizogenes (Research), No Winners Against AIDS Manfred Hartmann, Karl-
Chiron Teams with Via- Alessandro Pellegrineschi, (News), Jeffrey L. Fox Heinz Giihrs, Eckhard
gene in Gene Therapy Jean-Pierre Damon, Clinton Earns a Solid B+ Birch-Hirschfeid, Hans-Di-
(News), B.J. Spalding Nathalie Valtorta, Nicole for First Year (News), Russ eter Pohl, Steven Vand-
1994 Should See Firming Paillard, David Tepfer Hoyle erschueren, Frans Van de
Fundamentals (News), Characterization by Valuing the Emerging Di- Werf, Armand Michoel,
Mike Ward Electrospray Mass Spec- agnostics Industry (News), Désiré Collen, Detlev
Analyzing the Opportuni- trometry of Human Ca’**- John Kaiser Behnke
ties in U.S. Cotton (News), sensitive Cytosolic Phos- How Controversial are Sur- Was Robocop Just a
George Kidd pholipase A, Produced in rogate Endpoints? (News), Movie? (Book Review),
Two Firms Tackle Cord- Baculovirus-infeIcntseecdt Richard Mamelok Bernard Dixon
Blood Transplants (News), Cells (Research), Gerald W. Alliance Update (News), Patent Protection for Bio-
Joseph Alper Becker, James R. Miller, Mark Goodstein technology Inventions in
NIHRAC Okays Gene- Steven Kovacevic, Robert Product Update (News), Eastern Europe (BioTools),
Therapy Proposals (News), M. Wellis, Andrew I. Louis, Mike Ginsberg Elizabeth F. Enyati
Jeffrey L. Fox Jennifer S. Small, Daniel Therapeutic Approaches to Electrochemiluminesc-
Clinton’s New Env- H. Stark, Edda F. Roberts, Alzheimer’s Disease (Ar- ence: A New Diagnostic
ironmental-trade Policy Tamara K. Wyrick, JoAnn ticle), Robert S. Schehr and Research Tool
(News), Russ Hoyle Hoskins, X. Grace Chiou, Three-Dimensional Model- (BioTools), Hongjun Yang,
Alliance Update (News), John D. Sharp, Don B. ing and Drug Development Jonathan K. Leland, David
Mark Goodstein McClure, Ralph M. Riggin, (Article), Richard Peters, Yost, Richard J. Massey
Product Update (News), Ruth M. Kramer Robert C. McKinstry On Deck: The European
Mike Ginsberg Measurements of the Bulk Amino-Acid Fermen- Union (Editorial), John
Light, Angles, Action (Ar- Growth and Distribution of tation: Technology and Hodgson
ticle), John Hodgson Mammalian Cells in a Hol- Commodity Trading (Ar-
As We Live and Breathe: low-Fiber Bioreactor Using ticle), John Hodgson March
Free Radicals and Aging Nuclear Magnetic Reso- Epigenesis: The Missing 215 Factoring in Complexity
(Article), Stephen M. nance Imaging (Research), Beat in Biotechnology (Re- (Editorial), Susan Hassler
Edgington Rainer Callies, Michelle E. view), R. Strohman 218 Disquiet in the Classroom
Gene Therapy: Biotech’s Jackson, Kevin M. Brindle Elevated Levels of Super- (Editorial), Bernard Dixon
n+1 Technology (Article), New Year’s Resolutions oxide Dismutase Protect 222 Is Clinton Increasing
Nevin M. Summers (BioTools), Eugene C. Transgenic Plants Against Biotech R&D Spending?
Current Methods for Ma- Rzucidlo Ozone Damage (Research), (News), Jeffrey L. Fox
nipulating Baculoviruses Robotics and the Human W. Van Camp, H. Wil- 223 Gensia Files NDA for Car-
(Review), Anthony H. Genome Project (Bio- lekens, C. Bowler, M. Van diac Testing (News), Joseph
Davies Tools), Donald C. Uber Montagu, D. Inze P. Reu- Alper
Large Scale Cultivation of The Culture of Cryopres- pold-Popp, H. Sandermann Athena Files First NDA for
the Free Living Nematode ervation (BioQ&A), John Jr., C. Langebartels Zanaflex (News), B.J.
Caenorhabditis elegans Hodgson Bacteriophage Surface Dis- Spalding
(Research), Kodzo Gbew- It’s Time for the U.S. to play of an Immunoglobin- Analyzing Successful Busi-
onyo, Susan P. Rohrer, Rejoin UNESCO (Edito- binding Domain of Staphy- ness Strategies (News),
Leonard Lister, Bruce Bur- rial), Harvey Bialy lococcus aureus Protein A David Stone
gess, Doris Cully, Barry (Research), Baby M. Biotech Alliances Continue
Buckland February Djojonegoro, Michael J. to Evolve (News), Kenneth
An Isologous Porcine Pro- 111 Testing One, Two (Edito- Benedik, Richard C. Clark
moter Permits High Level rial), Susan Hassler Willson U.K. Biotech Will Boom
Expression of Human He- 113 Popular Science? (Edito- Mixed Lactic Acid-Alco- over Next Few Years
moglobin in Transgenic rial), Bernard Dixon holic Fermentation by Sac- (News), Mike Ward
Swine (Research), Ajay 115 Corange Puts $220 million charomyces cerevisiae Ex- Assessing Blood Substi-
Sharma, Mike J. Martin, into CellPro (News), B.J. pressing the Lactobacillus tutes (News), Jeffrey L. Fox
Jeannine F. Okabe, Ruth A. Spalding casei L(+)-LDH (Research), Biotech Fades in 1993 Ven-
Truglio, Nirpal K. Dhanjal, 116 Melville Files PLAs for Sylvie Dequin, Pierre Barre ture-Backed IPO Market
John S. Logan, Ramesh MelGAM and MelPLAS Increasing the Efficiency of (News), B.J. Spalding
Kumar (News), Joseph Alper Protein Export’ in EU Makes Three Moves to
Transgenic Birds by DNA 119 1993 Public Financing Escherichia coli (Re- Boost Biotech (News),
BIO/TECHNOLOGY VOL. 13 JANUARY 1995
Volume 12 1994 index Brings in $1.6 billion seaJurliacn Phére)z-P,ére z,
(News), B.J. Spalding Gabriel Marquez, José-Luis
Table Of Contents 1994 Will See Stocks Trade Barbero, Julio Gutiérrez
on Own Merits (News), R. Rapid Selection Using
Brandon Fradd G418 of High Copy Num-
The Dramatic Fall and Rise ber Transformants ofPichia
of Agracetus (News), pastoris for High-level For-
January Microinjection (Research), George Kidd eign Gene Expression (Re-
Not Science, but Necessary Jamie Love, Clare Gribbin, Nycomed Pharma Laun- search), Carol A. Scorer,
(Editorial), Susan Hassler Christine Mather, Helen ches Surgical Bandage Jeffrey J. Clare, William R.
Perpetual Rumination (Edi- Sang (News), Gerard O’ Dwyer McCombie, Michael A.
torial), Bernard Dixon Improvement of Ornamen- Drug Companies Must Be- Romanos, Koti Sreekrishna
FDA Panel Nixes Medim- tal Characters and Fra- friend Managed Care High Yield Production and
mune’s Respigam (News), grance Production in (News), B.J. Spalding Purification of Recombi-
Jeffrey L. Fox Lemon-scented Geranium Do Transgenic Crops Pose nant Staphylokinase for
Corange Sinks $206 Mil- Through Genetic Transfor- Ecological Risks? (News), Thrombolytic Therapy (Re-
lion into PDL (News), B.J. mation by Agrobacterium Jeffrey L. Fox search), Bernhard Schlott,
Spalding rhizogenes (Research), No Winners Against AIDS Manfred Hartmann, Karl-
Chiron Teams with Via- Alessandro Pellegrineschi, (News), Jeffrey L. Fox Heinz Giihrs, Eckhard
gene in Gene Therapy Jean-Pierre Damon, Clinton Earns a Solid B+ Birch-Hirschfeid, Hans-Di-
(News), B.J. Spalding Nathalie Valtorta, Nicole for First Year (News), Russ eter Pohl, Steven Vand-
1994 Should See Firming Paillard, David Tepfer Hoyle erschueren, Frans Van de
Fundamentals (News), Characterization by Valuing the Emerging Di- Werf, Armand Michoel,
Mike Ward Electrospray Mass Spec- agnostics Industry (News), Désiré Collen, Detlev
Analyzing the Opportuni- trometry of Human Ca’**- John Kaiser Behnke
ties in U.S. Cotton (News), sensitive Cytosolic Phos- How Controversial are Sur- Was Robocop Just a
George Kidd pholipase A, Produced in rogate Endpoints? (News), Movie? (Book Review),
Two Firms Tackle Cord- Baculovirus-infeIcntseecdt Richard Mamelok Bernard Dixon
Blood Transplants (News), Cells (Research), Gerald W. Alliance Update (News), Patent Protection for Bio-
Joseph Alper Becker, James R. Miller, Mark Goodstein technology Inventions in
NIHRAC Okays Gene- Steven Kovacevic, Robert Product Update (News), Eastern Europe (BioTools),
Therapy Proposals (News), M. Wellis, Andrew I. Louis, Mike Ginsberg Elizabeth F. Enyati
Jeffrey L. Fox Jennifer S. Small, Daniel Therapeutic Approaches to Electrochemiluminesc-
Clinton’s New Env- H. Stark, Edda F. Roberts, Alzheimer’s Disease (Ar- ence: A New Diagnostic
ironmental-trade Policy Tamara K. Wyrick, JoAnn ticle), Robert S. Schehr and Research Tool
(News), Russ Hoyle Hoskins, X. Grace Chiou, Three-Dimensional Model- (BioTools), Hongjun Yang,
Alliance Update (News), John D. Sharp, Don B. ing and Drug Development Jonathan K. Leland, David
Mark Goodstein McClure, Ralph M. Riggin, (Article), Richard Peters, Yost, Richard J. Massey
Product Update (News), Ruth M. Kramer Robert C. McKinstry On Deck: The European
Mike Ginsberg Measurements of the Bulk Amino-Acid Fermen- Union (Editorial), John
Light, Angles, Action (Ar- Growth and Distribution of tation: Technology and Hodgson
ticle), John Hodgson Mammalian Cells in a Hol- Commodity Trading (Ar-
As We Live and Breathe: low-Fiber Bioreactor Using ticle), John Hodgson March
Free Radicals and Aging Nuclear Magnetic Reso- Epigenesis: The Missing 215 Factoring in Complexity
(Article), Stephen M. nance Imaging (Research), Beat in Biotechnology (Re- (Editorial), Susan Hassler
Edgington Rainer Callies, Michelle E. view), R. Strohman 218 Disquiet in the Classroom
Gene Therapy: Biotech’s Jackson, Kevin M. Brindle Elevated Levels of Super- (Editorial), Bernard Dixon
n+1 Technology (Article), New Year’s Resolutions oxide Dismutase Protect 222 Is Clinton Increasing
Nevin M. Summers (BioTools), Eugene C. Transgenic Plants Against Biotech R&D Spending?
Current Methods for Ma- Rzucidlo Ozone Damage (Research), (News), Jeffrey L. Fox
nipulating Baculoviruses Robotics and the Human W. Van Camp, H. Wil- 223 Gensia Files NDA for Car-
(Review), Anthony H. Genome Project (Bio- lekens, C. Bowler, M. Van diac Testing (News), Joseph
Davies Tools), Donald C. Uber Montagu, D. Inze P. Reu- Alper
Large Scale Cultivation of The Culture of Cryopres- pold-Popp, H. Sandermann Athena Files First NDA for
the Free Living Nematode ervation (BioQ&A), John Jr., C. Langebartels Zanaflex (News), B.J.
Caenorhabditis elegans Hodgson Bacteriophage Surface Dis- Spalding
(Research), Kodzo Gbew- It’s Time for the U.S. to play of an Immunoglobin- Analyzing Successful Busi-
onyo, Susan P. Rohrer, Rejoin UNESCO (Edito- binding Domain of Staphy- ness Strategies (News),
Leonard Lister, Bruce Bur- rial), Harvey Bialy lococcus aureus Protein A David Stone
gess, Doris Cully, Barry (Research), Baby M. Biotech Alliances Continue
Buckland February Djojonegoro, Michael J. to Evolve (News), Kenneth
An Isologous Porcine Pro- 111 Testing One, Two (Edito- Benedik, Richard C. Clark
moter Permits High Level rial), Susan Hassler Willson U.K. Biotech Will Boom
Expression of Human He- 113 Popular Science? (Edito- Mixed Lactic Acid-Alco- over Next Few Years
moglobin in Transgenic rial), Bernard Dixon holic Fermentation by Sac- (News), Mike Ward
Swine (Research), Ajay 115 Corange Puts $220 million charomyces cerevisiae Ex- Assessing Blood Substi-
Sharma, Mike J. Martin, into CellPro (News), B.J. pressing the Lactobacillus tutes (News), Jeffrey L. Fox
Jeannine F. Okabe, Ruth A. Spalding casei L(+)-LDH (Research), Biotech Fades in 1993 Ven-
Truglio, Nirpal K. Dhanjal, 116 Melville Files PLAs for Sylvie Dequin, Pierre Barre ture-Backed IPO Market
John S. Logan, Ramesh MelGAM and MelPLAS Increasing the Efficiency of (News), B.J. Spalding
Kumar (News), Joseph Alper Protein Export’ in EU Makes Three Moves to
Transgenic Birds by DNA 119 1993 Public Financing Escherichia coli (Re- Boost Biotech (News),
BIO/TECHNOLOGY VOL. 13 JANUARY 1995
Mike Ward High-Level ATP Produc- Volume 12 1994 Index
The Gypsy Moth Contin- tion by a Genetically Engi-
ues Its Deadly Dance neered Candida Yeast (Re-
(News), George Kidd search), Yasuyoshi Sakai,
A Quixotic Assault on Tomohiro Rogi, Tetsu
Transgenic Plants (News), Yonehara, Nobuo Kato,
Russ Hoyle Yoshiki Tani
Stop Preaching to the Con- The State of Fingerprinting Tissue Engineering (Ar- lary Isoelectric Focusing of
verted (News), Jeffrey L. (Book Review), Peter ticle), Stephen M. Proteins (Biotools), Herb
Fox Gresshoff Edgington Schwartz, Tom Pritchett
Regulations are Strangling How to Avoid Patent In- Lipopraontd Heeairtn Dsis - Coordinating European
Medical Devices (News), fringement (Biotools), ease (Article), Jan Breslow Biotechnology Efforts
Howard Palefsky Kathleen Madden Williams The ABCs of Biotechnol- (Editorial), Jorn L. Mahler
Alliance Update (News), Clinical Trials Accelerator: ogy Lobbying Organiza-
Mark Goodstein Enterprise Document Man- tions in Europe (Article),
Product Update (News), agement (Biotools), Rob Justin Greenwood, Karsten Aging: A Rectifiable Mis-
Mike Ginsberg Reid Ronit take? (Editorial), Susan
Transgenic Fish: Safe to Another Anniversary for Drug Synthesis by Geneti- Hassler
Eat? (Article), David B. the War on Cancer (Edito- cally Engineered Microor- Keeping an Eye on B.
Berkowitz, Ilona Kryspin- rial), Gerald B. Dermer ganisms (Review), C. Ri- thuringiensis (Editorial),
Sgrensen chard Hutchinson Bernard Dixon
Long-Term Stabilization of April Protein Disulfide Isomerase FDA Nears Approval of
Biologicals (Article), Felix 327 TB Is Back, But the Pipe- Overexpression Increases Calgene’s Flavr Savr
Franks line Is Empty (Editorial), Secretion of Foreign Pro- (News), Jeffrey L: Fox
Process Validation in the Susan Hassler teins in Saccharomyces FDA “Screwed” Calgene,
Electronic Age (Article), 330 An Age-Old Dilemma (Edi- cerevisiae (Research), Anne Leaving Policy Vague
John Hodgson torial), Bernard Dixon Skaja Robinson, Victoria (News), Russ Hoyle
Transformation Systems 333 106 U.S. Biopharmaceut- Hines, K. Dane Wittrup U.S. Must Rationalize Bio-
for Generating Marker-Free ical Firms Lose $1.1 Bil- Pharmaceutical Capsules as tech Regulation (News),
Transgenic Plants (Re- lion (News), B.J. Spalding a Coating System for Arti- Henry Miller
view), John I. Yoder, An- Genta Seeks French Okay ficial Seeds (Research), Sacrificing Current Profits
drew P. Goldsbrough for Acne Drug (News), Jo- Jean-Marc Dupuis, Cath- for Future Gains (News),
Modification of Flower seph Alper erine Roffat, Richard T. George Kidd
Color in Florist’s Chrysan- LifeCell Introduces Skin DeRose, Francis Molle FDA Blesses Univax’s
themum: Production of a Replacement for Burns Effect of C.-C, Domain WinRho (News), David
White-Flowering Variety (News), B.J. Spalding Switching on Fab Activity Holzman
Through Molecular Genet- BioFirtms eGaicn Grheat er and Yield in Escherichia Lilly Acquires Sphinx for
ics (Research), Neal Bargaining Power (News), coli: Synthesis and Expres- $75 Million (News), B.J.
Courtney-Gutterson, Peter Drake, Gregory sion of Genes Encoding Spalding
Carolyn Napoli, Christine Brown Two Anti-Carbohydrate American Home Puts $57
Lemieux, Alison Morgan, Resetting the Model for Fabs (Research), C. Roger Million Into Affymax
Ebrahim Firoozabady, Long-Term Success MacKenzie, Vidhya (News), Joseph Alper
Karol E.P. Robinson (News), A. Grant Heidrich Sharma, David Brummell, Expect Success in Phase III
Accumulation of Fructose European Alliances Should Doris Bilous, Ginette Trials This Year (News), R.
Polymers in Transgenic Double by 2000 (News), Dubuc, Joanna Sadowska, Brandon Fradd
Tobacco (Research), Mike Ward N. Martin Young, David R. Vertex Turns a Profit
Michel J. Ebskamp, Ingrid ESCAgenetics’ Success Brundle, Saran A. Narang (News), Mike Ginsberg
M. van der Meer, Bertina with True Potato Seed Intracellular Immunization First Quarter Sees 33 Firms
A. Spronk, Peter J. (News), George Kidd with Cytosolic Recombi- Raise $592.9 Million
Weisbeek, Sjef C.M. NIH Nixes Human DNA nant Antibodies (Research), (News), B.J. Spalding
Smeekens Patents. What Next? Silvia Biocca , Paola Pier- Europe Takes the Lead in
Conservation of Genome (News), Jeffrey L. Fox andrei-Amaldi, Nadia Health-Care Reform
Structure Between Rice and NIH Scrutinizes Benefits of Campioni, Antonio Cat- (News), Martyn Greenacre,
Wheat (Research), Nori Technology Transfer taneo June Grindley
Kurata, Graham Moore, (News), Joseph Alper High-Level Expression of GATT’s Big Impact on
Yoshiaki Nagamura, Tracie U.K. Supermarket Labels Human Lipocortin I in the Biotech Patents (News),
Foote, Masahiro Yano, Recombinant Foods Fission Yeast Schizosac- Kevin J. McGough
Yuzo Minobe, Mike Gale (News), Louise Dughan charomyces pombe Using Leaping a Hurdle in Ma-
Acoustic Cell Filter for Will the Market Let BST a Novel Expression Vector laria- Vaccine Development
High Density Perfusion Strut Its Stuff? (NewsR)u,s s (Research), Yuko Giga- (News), Howard Engers
Culture of Hybridoma Cells Hoyle Hama, Hideki Tohda, Product Update (News),
(Research), Felix Trampler, Genetic Testing Assessed Hirofumi Okada, M. Koji Mike Ginsberg
Stefan A. Sonderhoff, in Three Reports (News), Owada, Hiroto Okayama, Alliance Update (News),
Phylis W.S. Pui, Douglas Leslie Steven Rothenberg Hiromichi Kumagai Mark Goodstein
G. Kilburn, James M. Piret NIHRAC Proposes Faster YACs for the Uninitiated Biotech’s New Nanotools
Single-Step Recovery of a Gene-Therapy Reviews (Book Review), Stephen (Article), Stephen M.
Secreted Recombinant Pro- (News), Jeffrey L. Fox Oliver Edgington
tein by Expanded Bed Ad- Alliance Update (News), Patenting Recipes From When “Make or Buy”
sorption (Research), Mark Goodstein Nature’s Kitchen Means “Make or Break”
Marianne Hansson, Stefan Product Update (News), (Biotools), Michael A. (Article), Ian J. Nicholson,
Stahl, Rolf Hjorth, Mathias Mike Ginsberg Gollin Peter Latham
Uhlén, Tomas Moks A New Force in Biotech: New Approaches to Capil- The Emergence of Biotech-
BIO/TECHNOLOGY VOL. 13 JANUARY 1995 79
Volume 12 1994 Index Matti Hyttinen, Minna Europe at BioWork: Chal-
Tolvanen, Jussi Aalto, lenges and Prospects (Ar-
Leena Alhonen, Riitta ticle), Sally Hayward, Mar-
Sinervirta, Maria Halm- tin Griffin
ekyt6, Sanna Myoéhianen, A Vital Interest: Science
Juhani Janne Education and the Biotech
Regeneration of Transgenic Industry (Article),
nology in Israel (Article), Roche and SKB Sink Big Rose (Rosa hybrida) Pianits Desmond Mascarenhas
John Hodgson Bucks into Genomics from Embryogenic Tissue Biopharmaceutical R&D
Apoptosis and Its Role in (News), B.J. Spalding (Research), Ebrahim Success Rates and Devel-
Human Disease (Review), MGI Pharma _ Hopes Firoozabady, York Moy, opment Times (Article),
Philip J. Barr, L. David Salagen Makes It Profitable Neal Courtney-Gutterson, Mark-M. Struck
Tomei (News), Joseph Alper Karol Robinson Towards Engineering Pro-
Production, Purification, GenVec and Theragen Join Production and Secretion teins by Site-Directed In-
and Immunogenicity of a in Gene Therapy (News), of Recombinant Proteins in corporation of Non-Natu-
Malaria Transmission- Mike Ginsberg Dictyostelium discoideum ral Amino Acids (Review),
Blocking Vaccine Candi- Sepracor Spins Out (Research), Werner Michael Ibba, Hauke
date: TBV25H Expressed BioSepra and HemaSure Dittrich, Keith L. Williams, Hennecke
in Yeast and Purified Using (News), Mark Goodstein Martin B. Slade Recombinant Polymeric
Nickel-NTA Agarose (Re- Biotech’s Clinical Trials DNA Amplification Finger- IgG: An Approach to Engi-
search), David C. Kaslow, and Tribulations (News), printing Using Arbitrary neering More Potent Anti-
Joseph Shiloach David Stone Mini-Hairpin Oligonucle- bodies (Research), Richard
Transgenic Tomato Plants High-Tech Pharmaceutical otide Primers (Research), I. F. Smith, Sherie L.
Exprethse Tsomiatno Ygel - Firms Move to the Fore Gustavo Caetano-Anollés, Morrison
low Leaf Curl Virus Capsid (News), Robert Stein Peter M. Gresshoff Biodegradable Polymer
Protein Are Resistant to the BIO’s Effective Lobbying Probing Diagnostics (Book Scaffolds for Tissue Engi-
Virus (Research), Talya Efforts (News), Jeffrey L. Review), Sanjay Tyagi neering (Research), Lisa E.
Kunik, Raffi Salomon, Fox Protein Sequencers as a Freed, Gordana Vunjak-
Daniel Zamir, Nir Navot, FDA Attacks Food Aller- Tool in Clinical Trials Novakovic, RobertJ. Biron,
Muhammad Zeidan, Ilana gens (News), Jeffrey L. Fox (BioTools), Jin Dong Zhao, Dana B. Eagles, Daniel C.
Michelson, Yedidya Gafni, FDA’s BST Policy Wreaks Mary Jean Pramik Lesnoy, Sandra K. Barlow,
Henryk Czosnek Havoc in the Market Health-Care Reform and Robert Langer
Antibaso Thderimoelabsil e (News), Russ Hoyle Intellectual Property (Edi- Efficient Expression of
Switches: High Tempera- Clinton’s Malign Neglect torial), Richard H. Drug-Selectable Genes in
ture Triggering for the Poly- Batters Biotechnology Kjeldgaard, David Marsh Retroviral Vectors Under
merase Chain Reaction (Re- (News), Henry Miller Control of an Internal Ribo-
search), David J. Sharkey, Funding Applied Research some Entry Site (Research),
Edward R. Scalice, Kenneth (News), David Singer Biotech’s Role in Science Yoshikazu Sugimoto, Ivan
G. Christy Jr., Susan M. The Bt Working Group Re- Education (Editorial), Su- Aksentijevich, Michael M.
Atwood, John L. Daiss ally Does Work (News), san Hassler Gottesman, Ira Pastan
Selecting Somatic Hybrid George Kidd Some Facts about Predic- Induction of Human Tissue
Plants Using Magnetic Pro- Product Update (News), tions (Editorial), Bernard Plasminogen Activator in
toplast Sorting (Research), Mike Ginsberg Dixon the Mammary Gland of
Inca Dorr, Stefan Miltenyi, Alliance Update (News), Biopharmaceutical Firms Transgenic Goats (Re-
Francesco Salamini, Mike Ginsberg Up R&D Spending 89% search), Karl M. Ebert, Paul
Helmut Uhrig Genome Mapping the (News), B.J. Spalding DiTullio, Cathleen A.
Efficient Sampling of Pro- “Easy” Way (Article), John Miles Sinks at least $38.5 Barry, Joanne E. Schindler,
tein Sequence Space for Hodgson Million into Onyx (News), Thomas E. Smith, Lisa J.
Multiple Mutants (Re- Ordering Up Big MACs Joseph Alper Pellerin, Harry M. Meade,
search), Robert Caren, (Article), Clare Huxley, FDA Finally Says MBI’s Julie Denman, Bruce Rob-
Rikke Mgrkeberg, Chaitan Christine Farr, Maria Laura Albunex is Approvable erts
Khosla Gennaro, Thomas Haaf (News), Mike Ginsberg Antibody-Targeted Pho-
In Pursuit of Rational Drug Amyloid Plaque and Dia- Investors Should Focus on tolysis of Bacteria In Vivo
Design (Book Review), betes (Article), Stephen M. Selected Stocks (News), (Research), Francois Berth-
Michael Ginsberg Edgington David Webber iaume, Steven R. Reiken,
When is a “Private” Con- Low-Dimensional Chaos in Agracetus’ Cotton Patent Mehmet Toner, Ronald G.
versation “Public” Disclo- Biological Systems (Re- Draws Opposition (News), Tompkins, Martin L.
sure? (BioTools), Kathleen view), James E. Skinner George Kidd, James Yarmush
Madden Williams Efficient and Rapid Affin- Dvorak Beneficial Microalgae
Shopping for a Contract ity Purification of Proteins Modified Seeds Reach Eu- (Book Review), Lee Yuan
Research Organization Using Recombinant Fusion ropean MarFikrste (Netws) , Kun
(BioTools), Judith Norkin Proteases (Research), Mike Ward Synthetic Peptide Combi-
Ecologically Sustainable Philip A. Walker, Louis E.- Can EPA Handle Commer- natorial Libraries
Biotechnology (Editorial), C. Leong, Patrick W.P. Ng, cial Release Requests? (BioTools), Dan Medynski
Anton Moser Shyh Han Tan, Sarah (News), Jeffrey L. Fox Legal Protection for Re-
Walker, David Murphy, Let’s Finally Get the Threat combinant Proteins
June Alan G. Porter of Virus-Resistant Plants (BioTools), Eugene C.
551 Biotech Goes To Trial (Edi- Generation of Transgenic Straight (News), Russ Rzucidlo, Dorothy R. Auth
torial), Susan Hassler Dairy Cattle from Hoyle Accelerating Drug Discov-
555 Don’t Believe (All) the Transgene-Analyzed and NIST Will Fund New DNA- ery (Editorial), Francis H.
Hype (Editorial), Bernard Sexed Embryos Produced Diagnostics Program Zenie
Dixon In Vitro (Research), Juha- (News), Jeffrey L. Fox
BIO/TECHNOLOGY VOL. 13 JANUARY 1995
August Functional Glutamate Re- Volume 12 1994 Index
743 Putting Value on Biotech ceptor Channels in Insect
Drugs (Editorial), Susan Celis (Research), Kari
Hassler Keinanen, Georg Kohr, Pe-
746 Debating Biotechnology terH. Seeburg, Marja-Leena
(Research), Bernard Dixon Laukkanen, Christian Oker-
750 Ciba-Geigy Sinks up to $99 Blom
Million in CoCensys Enhanced Protection Genzyme Transgenics Christina L. Hartman, Lisa
(News), Joseph Alper Against Fungal Attack by Buys TSI for $30 Million Lee, Peter R. Day, Nilgun
751 FDA Advisory Panel Okays Constitutive Co-Expression (News), Lesley Wright E. Tumer
Centocor’s ReoPro (News), of Chitinase and Glucanase FDA Derails Immunomed- Doubt and Certainty in Ge-
Jeffrey L. Fox Genes in Transgenic To- ics’ ImmuRAID-CEA netic Diagnosis (Book Re-
753 Second Quarter Sees 22 bacco(ResearQucnh Z)h,u, (News), Mike Ginsberg view), Lisa Baumbach
Firms Raise $272.4 Million Eileen A. Maher, Sameer EU Plans to Streamline Branched DNA Signal
(News), B.J. Spalding Masoud, Richard A. Dixon, GMO Regulations (News), Amplification (BioTools),
754 Second Quarter Sees Stock Chris J. Lamb Mike Ward Mickey S. Urdea
Continue to Slide (News), A Prototype Recombinant The Do’s and Don’ts of Transgene Inactivation:
R. Brandon Fradd Vaccine Against Respira- Preclinical Development Plants Fight Back! (Re-
Agbiotech Firms Increase tory Syncytial Virus and (News), Anthony Graffeo view), Jean Finnegan,
R&D Spending 43.6% Parainfluenza Virus Type What the Public Thinks David McElroy
(News), George Kidd, 3 (Research), Run-Pan Du, About Biotechnology (Ar- Hope on the Horizon (Edi-
James Dvorak Gail E.D. Jackson, Philip ticle), Bernard Zechendorf torial), Alex Brownstein
Canadian Biotech Lags Be- R. Wyde, Wei-Yao Yan, Commercializing Biotech
hind U.S. Biotech (News), Qijun Wang, Lucy Gisonni, Products (Article), Scott M. October
B.J. Spalding Sonia E. Sanhueza, Mary Wheelwright 951 Going Direct (Editorial),
Did FDA’s Kessler Tar E. Ewasyshyn Mammalian Cell Expres- Susan Hassler
Genetic Engineering? Overexpression of the Gene sion of Single-Chain 954 Biotech in Thailand (Edi-
(News), Russ Hoyle for Polyubiquitin in Yeast Fv(sFv) Antibody Proteins torial), Bernard Dixon
USDA Likely to Okay Confers Increased Secretion and Their C-Terminal Fu- 956 Lilly Continues Cherry-
Asgrow’s’ Engineered of a Human Leucocyte Pro- sions with Interleukin-2 and Picking the Biotech Sector
Squash (News), Jeffrey L. tease Inhibitor (Research), Other Effector Domains (News), Joseph Alper
Fox Yaping Chen, David Pioli, (Case Study), Haimanti Is it Time for the Biotech
NIH Reconsiders Nitrite’s Peter W. Piper Dorai, John E. McCartney, Sector to Laugh Yet?
Link to AIDS (News), John A Trademark Primer for Robert H. Hudziak, Mei- (News), Peter Drake, Gre-
Lauritsen Biotech (BioTools), Patrick Sheng Tai, James S. Huston, gory Brown
Is Corporate and Analyst Turley, Richard Siluk Hermann Oppermann U.K. Boasts Europe’s Big-
Hype Unethical? (News), Sepsis: The More, the Guiding the Selection of gest Public Sector (News),
Les Rothenberg Murkier (BioTools), Peter Human Antibodies from Vernon Spencer, David
Establishing the Utility of E. Highfield Phage Display Repertoires Kirk
Biotech Inventions (News), A Risk Analysis Model for to a Single Epitope of an Syntro Wins USDA Okay
Kevin J. McGough Experimental Veterinary Antigen (Research), for Advanced Vaccine
Places to Go for Companies Vaccines (BioTools), Cyril Laurent S. Jespers, Stephen (News), B.J. Spalding
Going Places (Special Sec- G. Gay M. Mahler, Greg Winter, Groupe Limagrain is a Top
tion), Roger E. Shamel, Questions About Genomes Hennie R. Hoogenboom Cooperative (News),
Michele Keough and Genome Projects (Edi- Enzymatic Separation of George Kidd, James
Why Not New York? (Spe- torial), Giorgio Bernardi High-Quality Uninked Pulp Dvorak
cial Section), Alex Fibers from Recycled EPA Finally Issues TSCA
Brownstein September Newspaper (Research), and FIFRA Rules (News),
Regional Development Or- 847 Protropin and Public Opin- Jonathan Woodward, Lyn- Jeffrey L. Fox
ganizations: An Interna- ion (Editorial), Susan ette M. Stephan, Laurence Analyzing EU and US.
tional Guide (Special Sec- Hassler J. Koran Jr., Ken K. Y. Agbiotech Field Trials
tion) 850 Environmentally Correct Wong, John N. Saddler (News), Mike Ward
The Changing Bulk Biotechnology (Editorial), Expansion of Hematopoi- Unfortunately, the Biodi-
Biocatalyst Market (Ar- Bernard Dixon etic Progenitor Cell Popu- versity Treaty is Dead
ticle), John Hodgson 852 Genxyme Sinks at Least lations in Stirred Suspen- (News), Russ Hoyle
Transgenic Pea Seeds Ex- $80 Million in Celtrix sion Bioreactors of Normal Industry Seeks New Creedo
pressing the a-Amylase In- (News), Joseph Alper Human Bone Marrow Cells for NIH CRADAs (News),
hibitor of the Common Bean 854 BioChem Pharma’s Big (Research), Peter W. Jeffrey L. Fox
are Resistant to Bruchid Push into Diagnostics Zandstra, James M. Piret Trade Associations Need
Beetles (Research), Rich- (News), Mark Goodstein Recombinant Bacillus Better Negotiating Skills
ard E. Shade, Hartmut E. In Shocking Synergen, thuringiensis Crystal Pro- (News), Henry Miller
Schroeder, José J. Pueyo, Sepsis Tallies Sixth Victim teins with New Properties: Stem Cell Factor Race
Linda M. Tabe, Larry L. (News), Lesley Wright Possibilities for Resistance Heats Up (News), B.J.
Murdock, T.J.V. Higgins, Who’s Afraid of Biotech Management (Research), Spalding
Maarten J.Chrispeels Consolidation? (News), Dirk Bosch, Bert Schipper, Surviving the ’90s: Can
Cell-Binding Peptides Con- David Stone Hilde van der Kleij, Ruud BioMasttere Clicnicahl T ri-
jugated to Poly(ethlyene Analyzing the Future of A. de Maagd, Willem J. als? (Article), Stephen M.
glycol) Promote Neural Cell Worldwide Agbiotech Stiekema Edgington
Aggregation (Research), (News), George Kidd Herbicide-Resistant Still Waters Run Deep (Ar-
Weiguo Dai, Jennifer Belt, Going Public Boosts Ex- Turfgrass (Agrostis palus- ticle), John Hodgson
W. Mark Saltzman ecutive Compensation tris Huds.) by Biolistic Recombinant Reproduction
804 High-Level Expression of (News), Mike Ginsberg Transformation (Research), (Article), Wim J. de
BIO/TECHNOLOGY VOL. 13 JANUARY 1995 81
Volume 12 1994 Index
tion of Periplasmic IGF-I Biotech Food Policy Still
from E. coli (Research), Staggering Along (News),
Roger A. Hart, Philip M. Jeffrey L. Fox
_ Lester, David: H. Amplification-Based Diag-
Reifsnyder, John R. Ogez, nostics Target TB (Article),
Stuart E. Builder Alexander Yule
High-Level Secretion and Environmental Biotechnol-
Koning, Gerald A. Walsh, Bargaining Power Shifts Very Efficient Isotopic La- ogy (Article), Stephen M.
Aileen S. Wrynn, Denis R. (News), B.J. Spalding beling of Tick Anticoagu- Edgington
Headon BMS Sinks up to $45 Mil- lant Peptide (TAP) Ex- Stirring the Fermentor of
Metabolic Flux Balancing: lion in Cadus (News), pressed in the Meth- Peace (Article), John
Basic Concepts, Scientific, Lesley Wright lyotrophic Yeast, Pichia Hodgson
and Practical Use (Review), Agbiotech Will Vertically pastoris (Research), Yves Plant Biotechnology: The
Amit Varma, Bernhard O. Integrate Agribusiness Laroche, Véronique Stor- “Jury” Decides (Article),
Palsson (News), Sano Shimoda me, Jan De Meutter, Joris Louise Dughan
Clonal Selection and Am- A Gutsy Map of the Future Messens, Marc Lauwereys The Behavior of Bacteria
plification of Phage Dis- of Agbiotech (News), A Significantly Improved Designed for Biodegrada-
played Antibodies by Link- George Kidd, James Semliki Forest Virus Ex- tion (Review), Juan L.
ing Antigen Recognition Dvorak pression System Based on Ramos, Eduardo Diaz,
and Phage Replication (Re- NIH and FDA Size Gene Translation Enhancer Seg- David Dowling, Victor de
search), Martin Duefias, Therapy (News), Jeffrey L. ments from the Viral Capsid Lorenzo, Sren Molin, Fergal
Carl A.K. Borrebaeck Fox Gene (Research), E. O’Gara, Cayo Ramos, Ken-
A Simple and Sensitive Gene Therapy Off to Slow Mathilda Sjéberg, Maarit -neth N. Timmis
High-Throughput Assay for Start (News), Jeffrey L. Fox Suomalainen, Henrik Recombinant Proteins Can
Steroid Agonists and An- NIH Panel Gives Green Garoff Be Isolated from E. coli
tagonists (Research), John Light to Embryo Research Rewiring Your Company Cells by Repeated Cycles
H. White, Kimberly A. (News), Jeffrey L. Fox for CANDA/CAPLA Sub- of Freezing and Thawing
McCuaig, Sylvie Mader The Unraveling of the mission (BioTools), Drew (Research), Brian H.
A Rapid Bioassay for Plate- Clinton Promise (News), Zinck, Donna Christiansen, Johnson, Michael H. Hecht
let-Derived Growth Factor Russ Hoyle John Lalor Detoxification of the Plant
B-Receptor Tyrosine Ki- Are You Wired to Pharm/ Phage Display: All Dressed Toxin Fluoroacetate by a
nase Function (Research), bio@internet? (News), Tom Up and Ready to Role Genetically Modified Ru-
Gerald F. Graminski, Anderson, Mary Cronin (BioTools), Dan Medynski men Bacterium (Research),
Michael R. Lerner Molecular Neurosurgery: Relaxing European Regu- Keith Gregg , Christopher
AHigh-Capacity Microbial Mending the Broken Brain lations (Editorial), Nigel L. Cooper, Darren J.
Screen for Inhibitors of (Article), Pedro R. Low- Jones Schafer, Helen Sharpe,
Human Rhinovirus Pro- enstein Cheryl E. Beard, Gillian
tease 3C (Research), J. Turning Up the Heat On December Allen, Jianwei Xu
Owen McCall, Sunil Rational Drug Design (Ar- 1311 Biotechnology and the Rapid Production of Fertile
Kadam, Leonard Katz ticle), John Ladbury, Rich- Road of Political Change Transgenic Plants of Rye
A Novel Approach for ard Peters (Editorial), Susan Hassler (Secale cereale L.), (Re-
High-Level Production of a Protein Purification: Tech- Taking Aim at Sexually search), Ana M. Castillo,
Recombinant Human Par- nical Improvements and Transmitted Diseases (Edi- Vimla Vasil, Indra K. Vasil
athyroid Hormone Frag- Legal Contretemps (Ar- torial), Bernard Dixon Establishment of Genetic
ment in Escherichia coli ticle), Igor Yu. Galaev, Bo Will Biogen and Teva Chal- Linkage by Allele-Specific
(Research), Hermann Mattiasson lenge Berlex in MS? Polymerase Chain Reac-
Gram, Paul Ramage, Klaus Oligonucleotide Arrays: (News), Joseph Alper tion: Application to the Lig-
Memmert, Rainer Gamse, New Concepts and Possi- European Firms Get New nin Peroxidase Gene Fam-
Hans Peter Kocher bilities (Review), Alexander Financing Opportunities ily of Phanerochaete chry-
1024 Longevity by Design (Book B. Chetverin, Fred Russell (News), Mike Ward sosporium (Research), Jill
Review), Philip J. Barr Kramer Report Plugs the Merits of Gaskell, Philip Stewart,
1025 Adverse Event Reporting Antisense Expression of European Biotech (News), Philip J. Kersten, Jakob
(BioTools), Stephen Polyphenol Oxidase Genes Mike Ward Reiser, Daniel Cullen
Hodgdon Inhibits Enzymatic Brown- Will Biotech Stocks Ever A Carbohydrate Biosensor
1040 Enabling Biodiversity (Edi- ing in Potato Tubers (Re- Rise Again? (News), David Surface for the Detection of
torial), Silvio Valle search), Christian W.B. Stone Uropathogenic Bacteria
Bachem, Gert-Jan Speck- U.S. Firms Should Seek (Research), Kurt G.I.
November mann, Piet C.G. van der Japanese Partners (News), Nilsson, Carl-Fredrik
1047 Are Biotech Companies Linde, Frank T.M. Ver- Farah Champsi Mandenius
Obsolete? (Editorial), Su- heggen, Michelle D. Hunt, Do Low-Price Guarantees Atherosclerosis Patents:
san Hassler John C. Steffens, Marc Maximize Profits? (News), Clues tothe Next Drug Gen-
1050 Citation Analysis and HIV Zabeau George Kidd, James eration (BioTools), Keith
(Editorial), Bernard Dixon Construction and Charac- Dvorak E. Suckling
1054 Baxter and DNX Team in terization of a Set of E. coli Trehalose Is a Sweet Target Using Information Services
Renal Transplantation Strains Deficient in All for Biotech (News), George to Gain a Competitive Ad-
(News), Joseph Alper Known Loci Affecting the Kidd, James Dvorak vantage (BioTools), Sandy
1055 Third Quarter Sees Stocks Proteolytic Stability of Se- AIDS Product Develop- Malloy
Stop Sliding (News), R. creted Recombinant Pro- ment Follows Its Own Rules Biotechnology: Africa’s
Brandon Fradd teins (Research), Hendrikus (News), Jeffrey L. Fox Beachhead for Entry into
1058 Third Quarter Sees 5 Firms J. Meerman, George The “AIDS Industry” Has the Global Economy (Edi-
Raise $64.3 Million (News), Georgiou Changed Significantly torial), Thomas R.
B.J. Spalding 1113 Large Scale, In Situ Isola- (News), Ezra Lwowski Odhiambo
$2 __BIO/TECHNOLOGY VOL. 13 JANUARY 1995
Special International
Du, Run-Pan, 813 Headon, Denis R., 988
Buyers’ Guide Issue Dubuc, Ginette, 390 Hecht, Michael H., 1357
Dueiias, Martin, 999 Heidrich, A. Grant, 342
Dughan, Louise, 351, 1346 Hennecke, Hauke, 678
Dupuis, Jean-Marc, 385 Higgins, T.J.V., 793
1161 Antibodies and 1238 Labware Dvorak, James, 659, 755, 964, Highfield, Peter E., 826
Antigens 1241 Liquid Handling 1064, 1326, 1328 Hines, Victoria, 381
1172 Bacterial and Cell 1247 Microscopy and Diaz, Eduardo, 1349 Hjorth, Rolf, 285
Analysis Optical Equipment Dorr, Inca, 511 Hodgdon, Stephen, 1025
Hodgson, John, 31, 82, 152, 208,
1176 Balances and Scales 1250 Nuclear E 259, 480, 581, 789, 983,
1176 Biotechnology Instrumentation Eagles, Dana B., 689 1344
Industry Services 1251 Recording Equipment, Ebert, Karl M., 699 Holzman, David, 445
1180 Chromatography Electrical, and Ebskamp, Michel J., 272 Hoogenboom, Hennie R., 899
1195 Clinical Diagnostics Electronic Equipment Edgington, Stephen M., 37, 361, Hoskins, JoAnn, 69
1201 Computer Hardware 1252 Spectroscopy 468, 591, 977, 1338 Hoyle, Russ, 26, 130, 236, 352,
and Software 1255 Technical, Analytical, Ellis, Robert M., 69 440, 570, 662, 760, 968,
1206 Electrophoresis and Research Engers, Howard, 461 1067
Enyati, Elizabeth F., 191 Hudziak, Robert H., 890
1212 Fermentors, Bioreac- 1262 Pharmaceutical
Ewasyshyn, Mary E., 813 Hunt, Michelle D., 1101
1215 tGoernse, raaln d MCoellel cuClualtru re IBnutlekr mRedaiwa teMsa t&er ials F HHuusttcohni,n soJna,m esC . SR.i,c 8h9a0rd , 375
Biology Alphabetical listing of Farr, Christine, 586 Huxley, Clare, 586
1226 Laboratory Animals biotechnology indus- Finnegan, Jean, 883 Hyttinen, Juha-Matti, 606
and Animal Care try suppliers Firoozabady, Ebrahim, 268, 609
1226 Laboratory and Foote, Tracie, 276 I
Scientific Apparatus Fox, Jef2f3r1e,y 2L3.9, , 143,4 82,4 , 315267,, 413298,, IInbzbéa,, DM.i,c h1a6e5l , 678
567, 568, 660, 664, 751,
761, 967, 970, 1065, 1066, J
Author Index 1067, 1329, 1332 Jackson, Gail E.D., 813
Fradd, R. Brandon, 120 Jackson, Michelle E., 75
A Cc Franks, Felix, 253 Jeffrey L., Fox, 222
Freed, Lisa E., 689 Jespers, Laurent S., 899
Aalto, Jussi, 606 Caetano-Anollés, Gustavo, 619
Johnson, Brian H., 1357
Aksentijevich, Ivan, 694 Callies, Rainer, 75 G Jones, Nigel, 1144
Alhonen, Leena, 606 Campioni, Nadia, 396 Gafni, Yedidya, 500 Janne, Juhani, 606
Allen, Gillian,, 1361 Caren, Robert, 517
Galaev, Igor Yu., 1086
Alper, Joseph, 23, 116, 223, 336, Castillo, Ana M., 1366 Gale, Mike, 276 K
349, 449, 560, 655, 750, Cattaneo, Antonio, 396
Gamse, Rainer, 1017 Kadam, Sunil, 1012
852, 956, 1054, 1317 Champsi, Farah, 1325
Garoff, Henrik, 1127 Kaiser, John, 132
Anderson, Tom, 1070 Chen, Yaping, 819 Gaskell, Jill, 1372 Kaslow, David C., 494
Atwood , Susan M., 506 Chetverin, Alexander B., 1093 Gay, Cyril G., 828 Kato, Nobuo, 291
Auth, Dorothy R., 713 Chiou, X.Grace, 69
Gbewonyo, Kodzo, 51 Katz, Leonard, 1012
Chrispeels, Maarten J., 793
B Christiansen, Donna, 1132 GGeenonrgairoou,, MGaeroirag eL,a ur1a1,0 75 86 KKeeionudgahne,n ,M iKcahreil,e ,8 047 69
Bachem, Christian W.B., 1101 Christy Jr, Kenneth G., 506 Giga-Hama, Yuko, 400 Kersten, Philip J., 1372
Barbero, José-Luis, 178 Clare, Jeffrey J., 181 Ginsberg, Michael, 29, 138, 243, Khosla, Chaitan, 517
Barlow, Sandra K., 689 Clark, Kenneth, 229 358, 452, 462, 521, 561, Kidd, George, 22, 122, 234, 347,
Barr, Philip J., 487, 1024 Collen, Désiré, 185 577, 579, 656, 860, 863 444, 577, 659, 755, 859,
Barre, Pierre, 173
Cooper , Christopher L., 1361 Gisonni, Lucy, 813 964, 1064, 1326, 1328
Barry, Cathleen A., 699
Courtney-Gutterson, Neal, 268, Goldsbrough, Andrew P., 263 Kilburn, Douglas G., 281
Baumbach, Lisa, 925 609 Gollin, Michael A., 406 Kirk, David, 958
Beard, Cheryl E., 1361 Cronin, Mary, 1070 Goodstein, Mark, 28, 136, 242, Kjeldgaard, Richard H., 639
Becker, Gerald W., 69 Cullen, Daniel, 1372 357, 463, 562, 854 van der Kleij, Hilde, 915
Behnke, Detlev, 185
Cully, Doris, 51 Gottesman, Michael M., 694 Kocher, Hans Peter, 1017
Belt, Jennifer, 797 Czosnek, Henryk, 500 Graffeo, Anthony, 865 de Koning, Wim J., 988
Benedik, Michael J., 169 Gram, Hermann, 1017 Koran Jr., Laurence J., 905
Berkowitz, David B., 247 D Graminski, Gerald F., 1008 Kovacevic, Steven, 69
Bernardi, Giorgio, 840
Dai, Weiguo, 797 Greenacre, Martyn, 456 Kramer, Fred Russell, 1093
Berthiaume, Francois, 703 Daiss, John L., 506 Greenwood, Justin, 371 Kramer, Ruth M., 69
Bialy, Harvey, 104 Damon, Jean-Pierre, 64 Gregg, Keith, 1361 Kryspin-Sorensen, Ilona, 247
Bilous, Doris, 390 Davies, Anthony H., 47 Gresshoff, Peter M., 619 Kumagai, Hiromichi, 400
Biocca, Silvia, 396 Day, Peter R., 919 Gribbin, Clare, 60 Kumar, Ramesh, 55
Birch-Hirschfeid, Eckhard, 185 De Meutter, Jan, 1119 Griffin, Martin, 667 Kun, Lee Yuan, 707
Biron, Robert J., 689 DeRose, Richard T., 385 Grindley, June, 456 Kunik, Talya, 500
Borrebaeck, Carl A.K., 999 Denman, Julie, 699 Gutiérrez, Julio, 178 Kurata, Nori, 276
Bosch, Dirk, 915 Dequin, Sylvie, 173 Giihrs, Karl-Heinz, 185 K6hr, Georg, 804
Bowler, C., 165 Dermer, Gerald B., 320
Breslow, Jan, 365 Dhanjal, Nirpal K., 55 H L
Brindle, Kevin M., 75 DiTullio, Paul, 699 Haaf, Thomas, 586 Ladbury, John, 1083
Brown, Gregory, 340, 957 Dittrich, Werner, 614 Halmekyté, Maria, 606 Lalor, John, 1132
Brownstein, Alex, 776, 944 Dixon, Bernard, 10, 113, 190,218, Hansson, Marianne, 285 Lamb, Chris J., 807
Brummell, David, 390 330, 435, 555, 651, 746, Hart, Roger A., 1113 Langebartels, C., 165
Brundle, David R., 390 850, 954, 1050, 1314 Hartman, Christina L., 919 Langer, Robert, 689
Buckland, Barry, 51 Dixon, Richard A., 807 Hartmann, Manfred, 185 Laroche, Yves, 1119
Builder, Stuart E., 1113 Djojonegoro, Baby M., 169 Hassler, Susan, 7, 111, 215, 327, Latham, Peter, 473
Burgess, Bruce, 51 Dora, Haimanti, 890 431, 551, 647, 743, 847, Laukkanen, Marja-Leena, 804
Dowling, David, 1349 951, 1047, 1311 Lauritsen, John, 762
Drake, Peter, 340, 957 Hayward, Sally, 667 Lauwereys, Marc, 1119
BIO/TECHNOLOGY VOL. 13 JANUARY 1995 83
Author Index Schwartz, Herb, 408 Vasil, Vimla, 1366
Scorer, Carol A., 181 Verheggen, Frank T.M., 1101
Seeburg, Peter H., 804 Vunjak-Novakovic, Gordana, 689
Shade, Richard E., 793
Lee, Lisa, 919 oO Shamel, Roger E., 769 Ww
Leland, Jonathan K., 193 O’ Dwyer, Gerard, 123 Sharkey, David J., 506 Walker, Philip A., 601
Lemieux, Christine, 268 O'Gara, Fergal, 1349 Sharma, Ajay, 55 Walker, Sarah, 601
Leong, Louis E.-C., 601 Odhiambo, Thomas R., 1400 Sharma, Vidhya, 390 Walsh, Gerald A., 988
Lerner, Michael R., 1008 Ogez, John R., 1113 Sharp, John D., 69 Wang, Qijun, 813
Lesnoy, Daniel C., 689 Okabe, Jeannine F., 55 Sharpe, Helen, 1361 Ward, Mike, 20, 230, 233, 345,
Lester, Philip M., 1113 Okada M., Hirofumi, 400 Shiloach, Joseph, 494 660, 864, 967, 1318, 1322
van der Linde, Piet C.G., 1101 Okayama, Hiroto, 400 Shimoda, Sano, 1062 Webber, David, 657
Lister, Leonard, 51 Oker-Blom, Christian, 804 Siluk, Richard, 824 Weisbeek, Peter J., 272
Logan, John S., 55 Oliver, Stephen, 405 Sinervirta, Riitta, 606 Wheelwright, Scott M., 877
de Lorenzo, Victor, 1349 Oppermann, Hermann, 890 Singer, David, 574 White, John H., 1003
Louis, Andrew I., 69 Owada, Koji, 400 Sjéberg, E. Mathilda, 1127 Willekens, H., 165
Love, Jamie, 60 P Skinner, James E., 596 Williams, Kathleen Madden, 523
Lowenstein, Pedro R., 1075 Slade, Martin B., 614 Williams, Keith L., 614
Lwowski, Ezra, 1331 Paillard, Nicole, 64 Small, Jennifer S., 69 Willson, Richard C., 169
Palefsky, Howard, 240 Smeekens, Sjef C.M., 272 Winter, Greg, 899
M Palsson, Bernhard O., 994 Smith, Richard LF., 683 Wittrup, K. Dane, 381
de Maagd, Ruud A., 915 Pastan, Ira, 694 Smith, Thomas E., 699 Wong, Ken K.Y., 905
MacKenzie, C. Roger, 390 Pellegrineschi, Alessandro, 64 Sonderhoff, Stefan A., 281 Woodward, Jonathan, 905
Madden, Kathleen, 297 Pellerin, Lisa J., 699 Spalding, B.J., 15, 16, 115, 119, Wright, Lesley, 855, 863, 1061
Mader, Sylvie, 1003 Peter, Gresshoff, 294 123, 224, 292, 335,. 338, Wrynn, Aileen S., 988
Maher, Eileen A., 807 Peters, Richard, 147, 1083 446, 453, 559, 652, 753, Wyde, Philip R., 813
Mahler, Jorn L., 424 Peura, Teija, 606 756, 962, 974, 1058, 1059 Wyrick, Tamara K., 69
Mahler, Stephen M., 899 Pierandrei-Amaldi, Paola, 396 Speckmann, Gert-Jan, 1101
Malloy, Sandy, 1381 Pioli, David, 819 Spencer, Vernon, 958 x
Mamelok, Richard, 134 Piper, Peter W., 819 Spronk, Bertina A., 272 Xu, Jianwei, 1361
Mandenius, Carl-Fredrik, 1376 Piret, James M., 281, 909 Sreekrishna, Koti, 181
Marsh, David, 639 Pohl, Hans-Dieter, 185 Stark, Daniel H., 69 Y
Martin, Mike J., 55 Porter, Alan G., 601 Steffens, John C., 1101 Yan, Wei-Yao, 813
Mascarenhas, Desmond, 671 Pramik, Mary Jean, 627 Stein, Robert, 565 Yang, Hongjun, 193
Masoud, Sameer, 807 Pritchett, Tom, 408 Stephan, Lynette M., 905 Yano, Masahiro, 276
Massey, Richard J., 193 Pueyo, José J., 793 Stewart, Philip, 1372 Yarmush, Mariin L., 703
Mather, Christine, 60 Pui, Phylis W.S., 281 Stiekema, Willem J., 915 Yoder, John I., 263
Mattiasson, Bo, 1086 Pérez-Pérez, Julian, 178 Stone, David, 226, 564, 858, 1322 Yonehara, Tetsu, 291
McCall, J. Owen, 1012 Storme, Véronique, 1119 Yost, David, 193
McCartney, John E., 890 R Strohman, R., 156 Young, N. Martin, 390
McClure, Don B., 69 Ramage, Paul, 1017 Struck, Mark-M., 674 Yule, Alexander, 1335
McCombie, William R., 181 Ramos, Cayo, 1349 Stahl, Stefan, 285
McCuaig, Kimberly A., 1003 Ramos, Juan L., 1349 Suckling, Keith E., 1379 Zz
McElroy, David, 883 Reid, Rob, 299 Sugimoto, Yoshikazu, 694 Zabeau, Marc, 1101
McGough, Kevin J., 458, 766 Reifsnyder, David H., 1113 Summers, Nevin M., 42 Zamir, Daniel, 500
Meade, Harry M., 699 Reiken, Steven R., 703 Suomalainen, Maarit, 1127 Zandstra, Peter W., 909
Medynski, Dan, 709, 1134 Reiser, Jakob, 1372 T Zechendorf, Bernard, 870
van der Meer, Ingrid M., 272 Reupold-Popp, P., 165 Zeidan, Muhammad, 500
Meerman, Hendrikus J., 1107 Riggin, Ralph M., 69 Tabe, Linda M., 793 Zenie, Francis H., 736
Memmert, Klaus, 1017 Robert C.McKinstry, 147 Tai, Mei-Sheng, 890 Zhao, Jin Dong, 627
Messens, Joris, 1119 Roberts, Bruce, 699 Tan, Shyh Han, 601 Zhu, Qun, 807
Michelson, Ilana, 500 Roberts, Edda F., 69 Tani, Yoshiki, 291 Zinck, Drew, 1132
Michoel, Armand, 185 Robinson, Anne Skaja, 381 Tepfer, David, 64
Miller, Henry, 441, 571, 972 Robinson, Karol E.P., 268, 609 Timmis, Kenneth N., 1349
Miller, James R., 69 Roffat, Catherine, 385 Tohda, Hideki, 400 See the
Miltenyi, Stefan, 511 Rogi, Tomohiro, 291 Tolvanen, Minna, 606
Minobe, Yuzo, 276 Rohrer, Susan P., 51 Tomei, L. David, 487
Moks, Tomas, 285 Romanos, Michael A., 181 Tompkins, Ronald G., 703
classified
Molin, Sgren, 1349 Ronit, Karsten, 371 Toner, Mehmet, 703
Molle, Francis, 385 Rothenberg, Les, 763 Trampler, Felix, 281
Moore, Graham, 276 Rothenberg, Leslie Steven, 354 Truglio, Ruth A., 55
Morgan, Alison, 268 Rzucidlo, Eugene C., 79, 713 Tumer, Nilgun E., 919 section
Morkeberg, Rikke, 517 Turley, Patrick, 824
Morrison, Sherie L., 683 Ss Tyagi, Sanjay, 624
for
Moser, Anton, 544 Saddler, John N., 905
Moy, York, 609 Sadowska, Joanna, 390 U
Murdock, Larry L., 793 Sakai, Yasuyoshi, 291 Uber, Donald C., 80
Murphy, David, 601 Salamini, Francesco, 511 Uhlén, Mathias, 285 information
Myohianen, Sanna, 606 Salomon, Raffi, 500 Uhrig, Helmut, 511
Marquez, Gabriel, 178 Saltzman, W. Mark, 797 Urdea, Mickey S., 926
Sandermann Jr., H., 165 on
N Sang, Helen, 60 V
Nagamura, Yoshiaki, 276 Sanhueza, Sonia E., 813 Valle, Silvio, 1040
Napoli, Carolyn, 268 Scalice, Edward R., 506 Valtorta, Nathalie, 64 upcoming
Narang, Saran A., 390 Schafer, Darren J., 1361 Van Camp, W., 165
Navot, Nir, 500 Schehr, Robert S., 140 Van Montagu, M., 165
Ng, Patrick W.P., 601 Schindler, Joanne E., 699 Van de Werf, Frans, 185 meetings
Nicholson, Ian J., 473 Schipper, Bert, 915 Vanderschueren, Steven, 185
Nilsson, Kurt G.I, 1376 Schlott, Bernhard, 185 Varma, Amit, 994
Norkin, Judith, 526 Schroeder, Hartmut E., 793 Vasil, Indra K., 1366
84 = BIO/TECHNOLOGY VOL. 13 JANUARY 1995
Engineering by
TEhveormlousttaibiolni zation of E. coli Ri- Posters that will appear at the February 4-9, 1995
bonuclease HI by Random Mu-
tagenesis The 1995
Kanaya, S., Haruki, M., Noguchi,
E. and Akasako, A. Miami
Improvement of Thermal Stabil- BIOTECHNOLOGY
ity of Enzymes in an Extreme Organized by The
Thermophile, Thermus thermo-
Philus: Artificial Evolution of En- Shania.
zymes in the Thermophile Winter
Yamagishi, A., Abe, J., Ryoji, M., SoeN OM ase
Akanuma, S., Aoshima, M.,
Symposia
Kotsuka, T., Tamakoshi, M. and Molecular Biology
Oshima, T.
Thermostabilization of 3- Foundation, Inc.
Isopropylmalate Dehydrogenase
from an Extreme Thermophile, and
Thermus thermophilus, by Intro-
ducing a Bulky Side Chain at
ation Bio Fechnology
Position 172 -
Akanuma, S., Yamagishi, A. and Symposia Magazine
Oshima, T.
Use of a Phage Peptide Library to
Isolate Peptide Sequences Bind- Advances in Gene
ing HIV-1 Nucleocapsid Protein
(NCp7) Technology: Protein
Calogero, R.A., Lener, D., Felici,
F., and Benarous, R. Engineering and
Engineering an Alteration in Sub-
strate Specificity of LDH by Structural Biology
Forced Evolution
Dafforn, T., Hawarani, A.,
Moreton, K. and Holbrook, J.J.
In Vivo Fusion System for Ran- Wunderlich, M., Bernstein, R., Unfolding of Allosteric Citrate
dom Protein Domain Shuffling Holak, T. and Glockshuber, R. Synthases: Effect of Cavity-Cre-
Demirjian, D.C., Weber, J.M., ating Mutants on the Stability of
Alavi, N., Gaines III, G. and Mutational Analysis of Residues the E. coli Enzyme
Casadaban, J. Determining the Sensitivity of Ayed, A. and Duckworth, H.W.
Barley a-Amylase 2 (AMY72) to
Evolution by Engineering: Amino the Barley a-Amylase/Subtilisin Probing the Thermodynamic and
Acid Substitutions at the Con- Inhibitor (BASI) Kinetic Role of the N and C Ter-
served Helix-Helix Interface of Rodenberg, K.W., Vallee, F., minal Helix-Helix Interaction in
Cytochrome c Juge, N., Guo, X-J., Chaix, J.C., the Folding of Cytochrome c
Doyle, D.F., Pielak, G.J., Auid, Haser, R. and Svennson, B. Colon, W., Elove, G.A., Sherman,
D.S., Beasley, J.R., Betz, S.F., F. and Roder, H.
Cohen, D.S., Finger, S.A., An Approach to Construction of
Fredericks, Z.L., Hilgen-Willis, Hybrid Proteins Structural Differences Between
S., Saunders, A.J. and Trojak, S.K. Schulga, A.A., Levichkin, L.V., IFN-c Species: «2b and a8b
Kurbanov, F.T. and Kirpich- Dipaola, M., Smith, T.A., Ogin,
Human Papillomavirus Type 16 nikov, M.P. E., Marcotte, J., Ferenez-Biro,
(HPV 16) Gene Expression: Spe- K., Liao, M-J. and Testa, D.
cific Probes Generation for De- Monovalent Cation Binding Lo-
tection of Late Open Reading cus in Class II E. coli Fructose Association of Protein Fragments
Frames (ORFs) Expression 1,6-Bisphosphate Aldolase Through a Second-Order Fold-
Ennaji, M.M., Arella, M., Sygusch, J., Tetreauli, S., Coul- ing Reaction: Structure of the Iso-
Belbarka, L., Merzouki, A. and ombe, R. and Muir, A. lated Fragments and Early Events
Phipps, J. of Protein Folding
Analysis and Design of Amino Prat, Gay, G. De, Ruiz-Sanz, J.,
Functional Complementation of a Acid Sequences by Neural Net- Davis, B. and Fersh, A.R.
Highly Conserved Protein Region works and Simulated Molecular
by Combinatorial Mutagenesis Evolution The Zinc-Binding Region of
Kless, H. and Vermaas, W. Wrede, P., Schuchhardt, J., Todt, Escherichia coli Glutamyl-tRNA
T. and Schneider, G. Synthetase Is Involved in tRNA
Role of Specific Amino Acids in Binding
Yeast Ribosomal Protein L1 in Protein Folding /n Gauthier, J. and Lapointe, J.
RNA Recognition Vivo
Lee, J.C. and Yeh, L-C.C. Oral Bioavailability of Partially Limiting Terminal Flexibility Is
Folded Proteins a Key for the Reversibility of
Structural Determinants of RNA Milstein, S. Thermal Denaturation of E. coli
Recognition by a Translational DHFR
Repressor Subunit Interactions, Chro- Iwakura, M. and Honda, S.
Spingola, M. and Peabody, D. mophore Attachment, and Pro-
teolysis in the Assembly of Unfolding of a '-Antitrypsin In- Effect of Amino Acid Changes at
Use of a Modified Filter Assay Cyanobacterial Light-Harvesting duced by Hydrophobic Interac- the Helix-Sheet Interface of
for Large-Scale Screening for Proteins tion Is Accompanied by B-Plas- Ubiquitin on the Thermodynam-
Protein Inhibitors with Altered Anderson, L., Plank, T., Toole, C. mid Fibril Formation ics and Kinetics of Folding
Binding Specificities and Cal, J. Janciauskiene, S. and Eriksson, S. Khorasanizadeh, S., Peters, I.D.
Maskos, K., Strobl, S., and Roder, H.
BIO/TECHNOLOGY VOL. 13 JANUARY 1995 85
Three-Dimensional Structure of Heteronuclear NMR and Model- Signaling from ATP Receptors to The 3-Dimensional Structure of
Calcium Depleted Thermostable ing Studies of the RAS-Like GTP- Map Kinase in Astrocytes the Light Harvesting Antenna
a-Amylase from Bacillus Binding Protein Cdc42Hs Neary, J.T., Zhu, Q., Akong, K., Complex (LH II) from Rps.
licheniformis at 2.2 A Resolution Feltham, J.L., Sutcliffe, M.J., Peterson, C. and Norenberg, acidophila, Strain 10050, at 2.5
Machius, M., Wiegand, G. and Cerione, R.A., Wagner, G. and M.D. A Resolution
Huber, R. Oswald, R.E. Isaacs, N.W., Mcdermott, G.,
Low Temperature Drives the Con- Prince, S.M. and Freer, A.A.
Characterization of the Structural Is Phosphorylated GAL4P Really formation of F29W/N-Domain
and Energetic Properties of the an Active Form as the Transcrip- Troponin C Mutant Towards the Concerted Binding of Ca** and
Intermediates on the Folding Path- tional Activator for Galactose- Calcium-Bound Form Dihydropyridine Ligands in the
way of PGK from Bacillus Inducible Genes in Yeast? Silva, J.L., Suarez, M.C., Barbosa, Pore of a Synthetic Ca** Channel:
stearothermophilus Fukasawa, T., Arichi, A., C., Foguel, D., Sorenson, M. and A Computational Study
Parker, M., Burston, S., Jackson, Amakasu, H., Sakurai, H. and Smillie, L.B. Ananthanarayanan, V.S. and
G., Spencer, J., Staniforth, R. and Handa, H. Zhorov, B.S.
Clarke, A. Characterization of Calmodulins
Immunophilins FKBP12 and Containing the Unnatural Me- Structural Model of the
Reassociation of Triosephosphate FKBP13: Genetic Engineering of thionine Analogs Norleucine and Phospholamban Ion Channel in
Isomerase in Reverse Micelles Calcineurin Affinity Ethionine Membranes
Measured by Energy Transfer Futer, O., Decenzo, T., Aldape, Vogel, H.J. and Yuan, T. Arkin, I.T., Adams, P.D., Ludlam,
Sepulveda-Becerra, M.A., Fer- R.A. and Livingston, D.J. Mutational Analysis of the Effec- C.F.C., Aimoto, S., Rothschild,
reira, S.T., Strasser, R., Garzon- tor Domain of Elongation FactorG K.J., Brunger, A.T., Engelman,
Rodriguez, W., Beltran, C., D.M. and Smith, S.O.
Gomez-Puyou and Darszon, A.
Probing Bacteriocin 28B Mem-
Pressure and Low Temperature DNA Preparation Kit for PCR brane Insertion by Disulphide
Stability of Wild Type and the Bond Engineering
Mutant T2941 Procapsid Shells Enfedaque, J., Overington, J.,
of P22 Bacteriophage Pattus, F. and Regue, M.
Sousa Jr., P.C., Silva, J.L., In less than 30 minutes
Foguel, D., Teschke, C.M. and and only 10 steps, Split Connexin 43 (Cx 43) Expression
Prevelige, P.E. Is Reduced in Human
Second DNA Prepara- Papillomavirus Type 16 (HPV 16)
Folding of Outer Membrane Pro- Transfected Rat Myoblasts (L,
tein A: Characterization of Two tion Kit produces PCR- Cells)
Membrane-Bound Forms ready DNA from human Ennaji, M.M., Belbaraka, L.,
Tamm, L.K., Rodionova, N.A., Jouishomme, H. and Phipps, J.
Tatulian, S.A., Surrey, T. and whole blood. Because
Jahnig, F. Understanding the Function of
all preparation takes place in a single microfuge Bacterial MDRs Through Struc-
The Crystal Structure of Porcine tural Analysis
tube, Split Second maximizes safety by minimizing
Pancreatic o-Amylase in Com- Lewis, K.
plex with the Microbial Inhibitor exposure to infectious agents. The kit eliminates
Tendamistat Study and Characterization of the
Wiegand, G., Epp, O. and Huber, hazardous phenol/chloroform extractions, and lym- Erythropoietin Receptor in the
R. Nervous System
phocyte separation gradients, as well as tedious
Lin, R.S., and Lodish, H.F.
Role of Disulfide Bonds in the ethanol precipitations. Each kit provides all the
Refolding of Recombinant Recent Progress in the Structure
Prochymosin reagents necessary for preparing 50-250 blood Determination of a-Hemolysin,
Yang, K., Zhang, Y. and Liu, N. a Transmembrane Pore
samples for PCR. Split Second is ideal for simulta- Hobaugh, M.R., Song, L.,
Enhanced Folding and Process- neously processing large numbers of human whole Balciunas, A., Cheley, S., Shustak,
ing of a Cysteine to Alanine Mu- C., Bayley, H. and Gouaux, J.E.
tant of the Human Aslaloglyco- blood samples for PCR.
protein Receptor Isolation, Characterization, and
Yuk, M.H. and Lodish, H.F. Regulation of Gravidin, a Phos-
pholipase A2 Inhibitor
Signal Transduction Wilson, T. and Schuster-
Multidimensional NMR Studies Woldan, N.
of the Structure and Dynamics of
Calcium-Free Calmodulin J Preliminary Analysis of the Phos-
Zhang, M., Tanaka, T., Farrow, pholipid Requirement for the
N.A., Kay, L.E. and Ikura, M. Anchoring of Penicillin Binding
Protein 5 to the Inner Membrane
Identification of Contract Sites of Escherichia coli
Involved in Rhodopsin- Expression of ETS Family Genes Wolfe, M.A. and Breitenberger, Phoenix, D.A., Harris, F. and
Transducin Coupling in Systemic Lupus Erythematosus CA. Chatfield, L.
Acharya, S. and Karnik, S. Georgiou, P.E., Chen, S-L.,
Suzuki, H., Romano-Spica, V., High-Resolution Crystal Struc- Comparison of the Potential
A p185""-Containing Signal Lautenberger, J.A., Papas, T.S. ture of a Crk SH3 Domain with Membrane Insertion Geometries
Transduction Particle Associated and Bhat, N.K. Its Specific Ligand of Escherichia coli Low Molecu-
with Microfilaments in Mammary Wu, X., Knudson, B.S., Feller, lar Weight Penicillin Binding Pro-
Adenocarcinoma Microvilli On the Model of Feedback Regu- S.M., Hanafusa, H. and Kuriyan, J. tein Anchors
Carothers-Carraway, C., Carva- lation of Heat Shock Gene Ex- Phoenix, D.A., Pewsey, A., Rob-
jal, M., Lorenzo, D. and pression by Heat Shock Proteins: Membrane Proteins erts, M.G. and Harris, F.
Carraway, K.L. Demonstration of Heat Shock Three-Dimensional Solution
Protein 70-Containing Com- Structure and Calcium Interac- Understanding
The Integral Membrane Subunit plexes of Unactivated Heat Shock tion of the Epithelial Cadherin Catalysis
of the Sialomucin Complex of Transcription Factor 1 Domain Responsible for Selec- Investigations of the Folate Bind-
Ascites 13762 Rat Mammary Guettouche, T., Baier, R. and tive Cell Adhesion ing Site in E. coli Dihydrofolate
Adenocarcinoma Cells Stimulates Voellmy, R. Ikura, M., Overduin, M., Harvey, Reductase by Kinetic Studies and
Phosphorylation of the EGF Re- T.S., Bagby, S., Tong, K.L., Yau, Random Mutagenesis
ceptor and p185"* Transcriptional Activation ofdctA P. and Takeichi, M. Huang, Z., Wagner, C.R. and
Carraway, K.L., Carraway III, in R. meliloti Benkovic, S.J.
K.L., Guy, P.M., Rossi, E., Kaufman, R.I. and Nixon, B.T.
Lorenzo, D., Cerione, R.A. and
Carraway, C.A.C.
86 _BIO/TECHNOLOGY VOL. 13 JANUARY 1995