Biosignal Processing: Principles and Practices

212 Pages·2013·25.6 MB·English

by  Hualou Liang, Joseph D. Bronzino, Donald R. Peterson

Biosignal
Processing
PrinciPles Practices
and

Biosignal
Processing
PrinciPles Practices
and
edited by
Hualou liang
Joseph d. Bronzino
donald r. Peterson
CRC Press
Taylor & Francis Group
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© 2013 by Taylor & Francis Group, LLC
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Version Date: 20120608
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Contents
Preface.............................................................................................................................................vii
Editors..............................................................................................................................................ix
Contributors...................................................................................................................................xi
. 1. Digital.Biomedical.Signal.Acquisition.and.Processing.......................................1-1
Luca T. Mainardi, Anna M. Bianchi, and Sergio Cerutti
. 2. Time–Frequency.Signal.Representations.for.Biomedical.Signals.....................2-1
G. Faye Boudreaux-Bartels and Robin Murray
. 3. Multivariate.Spectral.Analysis.of.Electroencephalogram:.
Power, Coherence, and.Second-Order.Blind.Identification...............................3-1
Ramesh Srinivasan and Siyi Deng
. 4. General.Linear.Modeling of.Magnetoencephalography.Data............................4-1
Dimitrios Pantazis, Juan Luis Poletti Soto, and Richard M. Leahy
. 5. Emergence.of.Groupwise.Registration.in.MR.Brain.Study................................5-1
Guorong Wu, Hongjun Jia, Qian Wang, Feng Shi, Pew-Thian Yap,
and Dinggang Shen
. 6. Functional.Optical.Brain Imaging............................................................................6-1
Meltem Izzetoglu
. 7. Causality.Analysis.of.Multivariate.Neural.Data............................................7-1
Maciej Kamin´ski and Hualou Liang
v

Preface
Biosignal.processing.has.been.around.for.decades,.but.it.still.seems.to.be.growing.in.popularity..With.
the.rise.of.advanced.computerized.data.collection.systems,.monitoring.devices,.and.instrumentation.
technologies,.large.and.complex.datasets.simply.accrue.as.an.inevitable.part.of.biomedical.enterprise..The.
availability.of.large.quantities.of.biomedical.data.not.only.offers.unprecedented.opportunities.to.advance.
our.understanding.of.the.underlying.biological.and.physiologic.functions,.structures,.and.dynamics.but.
also.drives.tremendous.progress.toward.innovative.methods.in.biosignal.processing..As.such,.this.field.
has.advanced.to.a.conspicuous.stage.that.biosignal.processing.has.become.an.integral.part.in.all.phases.
of.biomedical.research.and.development.
The.purpose.of.this.book.is.to.provide.state-of-the-art.coverage.of.contemporary.methods.in..biosignal.
processing.with.an.emphasis.on.brain.signal.analysis..The.first.two.chapters.in.this.book.present.
.fundamental.aspects.of.biomedical.signal.processing,.which.should.be.accessible.to.the.general.audi-
ence..Chapter.1.provides.a.general.overview.of.basic.concepts.in.biomedical.signal.acquisition.and.
processing,.whereas.Chapter.2.deals.with.the.nonstationary.and.transient.nature.of.signals.by.intro-
ducing.time−.frequency.analysis.and.discusses.its.applications.to.signal.analysis.and.detection.prob-
lems.in.bioengineering.
The.next.four.chapters.address.emerging.methods.for.brain.signal.processing,.each.focusing.on.spe-
cific.noninvasive.imaging.techniques.such.as.electroencephalography.(EEG),.magnetoencephalography.
(MEG),.magnetic.resonance.imaging.(MRI),.and.functional.near-infrared.spectroscopy.(fNIR)..Chapter 3.
covers.a.multivariate.spectral.analysis.of.EEG.data.using.power,.coherence,.and.second-order.blind.
identification..Chapter.4.introduces.a.general.linear.modeling.approach.for.the.analysis.of.induced.and.
evoked.responses.in.MEG..Chapter.5.presents.the.progress.in.groupwise.registration.algorithms.for.
effective.MRI.medical.image.analysis..Chapter.6.describes.the.basis.of.optical.imaging,.fNIR.instru-
mentation,.and.signal.analysis.in.various.cognitive.studies.
Chapter.7.reviews.recent.advances.of.causal.influence.measures.such.as.the.Granger.causality.for.analyz-
ing.multivariate.neural.data..For.basic.applications,.the.emphasis.is.on.the.typical.analysis.of.spike.trains,.
EEG,.and.fMRI.BOLD.data,.each.representing.a.major.recording.modality.used.in.neuroscience.research..
For.clinical.applications,.epileptogenic.seizure.localization.is.selected.as.a.direct.demonstration.
The.topics.covered.in.this.book.reflect.an.ongoing.evolution.in.biosignal.processing..As.biomedical.
datasets.grow.larger.and.more.complicated,.emerging.signal.processing.methods.that.analyze.and.inter-
pret.these.data.have.gained.in.importance..We.hope.that.this.book.will.aid.the.process.for.biosignal.
.analysis.and.stimulate.new.ideas.and.opportunities.for.developing.cutting-edge.computational.methods.
for..biosignal.processing,.which.will.in.turn.accelerate.laboratory.discoveries.into.treatments.for.patients..
All.the.contributors.of.this.book.share.this.vision.and.herein.are.gratefully.recognized.for.donating.their.
.talent and.time.so.that.the.promise.of.biosignal.processing.will.be.fulfilled.
Hualou Liang
Philadelphia, Pennsylvania
vii

Editors
Hualou Liang.is.a.professor.at.Drexel.University,.School.of.Biomedical.Engineering..Dr..Liang.received.
his.PhD.in.physics.from.the.Chinese.Academy.of.Sciences,.Beijing,.China..He.studied.signal.processing.
at.Dalian.University.of.Technology,.Dalian,.China..Dr..Liang.has.been.a.postdoctoral.researcher.in.Tel-
Aviv.University,.Israel,.Max.Planck.Institute.for.Biological.Cybernetics,.Germany,.and.the.Center.for.
Complex.Systems.and.Brain.Sciences,.Florida.Atlantic.University,.USA.
Professor.Liang.focuses.his.research.study.on.neuroengineering,.neuroinformatics,.functional.brain.
imaging,.cognitive.and.computational.neuroscience,.and.biomedical.signal.processing..Dr..Liang’s.team.
explores.neural.mechanisms.of.visual.perception.during.various.cognitive.tasks.using.computational.
approaches..His.recent.work.deals.with.(1).development.of.software.package.(www.brain-smart.org).for.
analyzing.brain.circuits,.(2).neuronal.oscillations.and.attentional.control,.(3).development.of.advanced.
signal.processing.methods.for.the.analysis.of.nonstationary,.multivariate.neurobiological.data.(spikes,.
field.potentials,.EEG/MEG,.fMRI,.etc.),.and.(4).algorithm.development.for.brain–computer.interface.or.
brain–machine.interface.
Joseph D. Bronzino.received.a.BSEE.from.Worcester.Polytechnic.Institute,.Worcester,.Massachusetts,.
in.1959,.an.MSEE.from.the.Naval.Postgraduate.School,.Monterey,.California,.in.1961,.and.a.PhD.in.
electrical.engineering.from.Worcester.Polytechnic.Institute.in.1968..He.is.presently.the.Vernon.Roosa.
Professor.of.Applied.Science,.an.endowed.chair.at.Trinity.College,.Hartford,.Connecticut,.and.president.
of.the.Biomedical.Engineering.Alliance.and.Consortium.(BEACON),.which.is.a.nonprofit.organization.
consisting.of.academic.and.medical.institutions.as.well.as.corporations.dedicated.to.the.development.of.
new.medical.technology..To.accomplish.this.goal,.BEACON.facilitates.collaborative.research,.industrial.
partnering,.and.the.development.of.emerging.companies.
Dr..Bronzino.is.the.author.of.over.200.journal.articles.and.15.books,.including.Technology for Patient
Care.(C.V..Mosby,.1977),.Computer Applications for Patient Care.(Addison-Wesley,.1982),.Biomedical
Engineering: Basic Concepts and Instrumentation.(PWS.Publishing.Co.,.1986),.Expert Systems: Basic
Concepts (Research.Foundation.of.State.University.of.New.York,.1989),.Medical Technology and Society:
An Interdisciplinary Perspective.(MIT.Press.and.McGraw-Hill,.1990),.Management of Medical Technology
(Butterworth/Heinemann,.1992),.The Biomedical Engineering Handbook (CRC.Press,.1st.Edition,.1995;.
2nd.Edition,.2000;.3rd.Edition,.2006),.Introduction to Biomedical Engineering.(Academic.Press,.1st.
Edition,.1999;.2nd.Edition,.2006),.Biomechanics: Principles and Applications.(CRC.Press,.2002),.
Biomaterials: Principles and Applications (CRC.Press,.2002), Tissue Engineering (CRC.Press,.2002),.and.
Biomedical Imaging.(CRC.Press,.2002).
Dr..Bronzino.is.a.fellow.of.IEEE.and.the.American.Institute.of.Medical.and.Biological.Engineering.
(AIMBE),.an.honorary.member.of.the.Italian.Society.of.Experimental.Biology,.past.chairman.of.the.
Biomedical.Engineering.Division.of.the.American.Society.for.Engineering.Education.(ASEE),.a.charter.
member.of.the.Connecticut.Academy.of.Science.and.Engineering.(CASE),.a.charter.member.of.the.
American.College.of.Clinical.Engineering.(ACCE),.a.member.of.the.Association.for.the.Advancement.
ix