file:///J|/medmcblgy/cover.html Cover file:///J|/medmcblgy/cover.html5/10/2006 8:38:11 PM file:///J|/medmcblgy/page_i.html Page i Medical Microbiology file:///J|/medmcblgy/page_i.html5/10/2006 8:38:21 PM file:///J|/medmcblgy/page_i%20(1).html Page ii BIOS INSTANT NOTES Series Editor: B.D.Hames, School of Biochemistry and Molecular Biology, University of Leeds, Leeds, UK Biology Animal Biology, Second Edition Biochemistry, Third Edition Bioinformatics Chemistry for Biologists, Second Edition Developmental Biology Ecology, Second Edition Genetics, Second Edition Immunology, Second Edition Mathematics & Statistics for Life Scientists Medical Microbiology Microbiology, Second Edition Molecular Biology, Third Edition Neuroscience, Second Edition Plant Biology, Second Edition file:///J|/medmcblgy/page_i%20(1).html (1 of 2)5/10/2006 8:38:42 PM file:///J|/medmcblgy/page_i%20(1).html Sport & Exercise Biomechanics Sport & Exercise Physiology Chemistry Consulting Editor: Howard Stanbury Analytical Chemistry Inorganic Chemistry, Second Edition Medicinal Chemistry Organic Chemistry, Second Edition Physical Chemistry Psychology Sub-series Editor: Hugh Wagner, Dept of Psychology, University of Central Lancashire, Preston, UK Cognitive Psychology Physiological Psychology Psychology Sport & Exercise Psychology file:///J|/medmcblgy/page_i%20(1).html (2 of 2)5/10/2006 8:38:42 PM file:///J|/medmcblgy/page_i%20(2).html Page iii Medical Microbiology Professor Will Irving Department of Microbiology, University Hospital, Queens Medical Centre, Nottingham, UK Professor Dlawer Ala’Aldeen Department of Microbiology, University Hospital, Queens Medical Centre, Nottingham, UK Dr Tim Boswell Nottingham City Hospital NHS Trust, Nottingham, UK file:///J|/medmcblgy/page_i%20(2).html5/10/2006 8:38:46 PM file:///J|/medmcblgy/page_i%20(3).html Page iv Published by: Taylor & Francis Group In US: 270 Madison Avenue New York, NY 10016 In UK: 4 Park Square, Milton Park Abingdon, OX14 4RN © 2005 by Taylor & Francis Group First published 2005 This edition published in the Taylor & Francis e-Library, 2006. To purchase your own copy of this or any of Taylor & Francis or Routledge’s collection of thousands of eBooks please go to www.eBookstore.tandf.co.uk. ISBN 0-203-48815-6 Master e-book ISBN ISBN 0-203-62517-X (OEB Format) ISBN: 1-8599-6254-8 (Print Edition) This book contains information obtained from authentic and highly regarded sources. Reprinted material is quoted with permission, and sources are indicated. A wide variety of references are listed. Reasonable efforts have been made to publish reliable data and information, but the author and the publisher cannot assume responsibility for the validity of all materials or for the consequences of their use. All rights reserved. No part of this book may be reprinted, reproduced, transmitted, or utilized in any form by any electronic, mechanical, or other means, now known or hereafter invented, including photocopying, microfilming, and recording, or in any information storage or retrieval system, without written permission from the publishers. A catalog record for this book is available from the British Library. Library of Congress Cataloging-in-Publication Data Irving, William L. Medical microbiology / Will Irving, Dlawer Ala′Aldeen, Tim Boswell. p.; cm.—(BIOS instant notes) Includes index. ISBN 1-85996-254-8 (alk. paper) 1. Medical microbiology—Outlines, syllabal, etc. [DLM: 1. Communicable Diseases—microbiology—Outlines. 2. Infection—microbiology—Outlines. 3. Bacterial Infections microbiology—Outlines. 4. Mycoses—microbiology—Outlines. 5. Parasitic Diseases—microbiology—Outlines. file:///J|/medmcblgy/page_i%20(3).html (1 of 2)5/10/2006 8:38:47 PM file:///J|/medmcblgy/page_i%20(3).html 6. Virus Diseases—microbiology—Outlines. QW 18.2 I72m 2005] I. Ala’Aldeen, Dlawer A.A. II. Boswell, Tim. III. Title. IV. Series. QP46.I78 2005 616.9’041–dc22 2005022853 Editor: Elizabeth Owen Editorial Assistant: Chris Dixon Production Editor: Georgina Lucas/Simon Hill Typeset by: Phoenix Photosetting, Chatham, Kent, UK Printed by: TJ International, Padstow, Cornwall Taylor & Francis Group is the Academic Division of T&F Informa Plc. Visit our web site at http://www. garlandscience.com file:///J|/medmcblgy/page_i%20(3).html (2 of 2)5/10/2006 8:38:47 PM file:///J|/medmcblgy/page_i%20(5).html Page v CONTENTS Abbreviations vii Preface ix Section A Microbial pathogenesis A1 Introduction microbiology 1 A2 Host defense mechanisms to infection 9 A3 Viruses and virus replication 17 A4 Viral pathogenesis 24 A5 Bacterial anatomy 28 A6 Bacterial survival mechanisms 34 A7 Bacterial pathogenicity 38 A8 Prions 43 Section B Human pathogens: viruses B1 Human immunodeficiency viruses 47 B2 Hepatitis A and E viruses 51 B3 Hepatitis B and D viruses 55 B4 Hepatitis C virus 61 file:///J|/medmcblgy/page_i%20(5).html (1 of 3)5/10/2006 8:38:48 PM file:///J|/medmcblgy/page_i%20(5).html B5 Herpes simplex viruses 64 B6 Varicella-zoster virus 68 B7 Cytomegalovirus, HHV-6 and -7 71 B8 Epstein-Barr virus and HHV-8 74 B9 Rhinoviruses and coronaviruses 77 B10 RSV, hMPV, and parainfluenza viruses 81 B11 Influenza viruses 85 B12 Adenoviruses 89 B13 Measles and mumps viruses 91 B14 Rota-viruses and caliciviruses 95 B15 Entero viruses 98 B16 Rubella virus and parvovirus B19 100 B17 Arena-, filo-, flavi- and rhabdoviruses 104 B18 Poxviruses 107 B19 Papilloma- and polyomaviruses 110 Section C Human pathogens: bacteria Gram-positive bacteria C1 Staphylococci 113 C2 Streptococci and Enterococci 116 C3 Bacillus species 120 C4 Corynebacteria 123 C5 Listeria 126 C6 Mycobacteria 129 Gram-negative bacteria C7 Enterobacteriaceae 133 C8 Pseudomonas and related organisms 140 file:///J|/medmcblgy/page_i%20(5).html (2 of 3)5/10/2006 8:38:48 PM file:///J|/medmcblgy/page_i%20(5).html C9 Parvobacteria 143 file:///J|/medmcblgy/page_i%20(5).html (3 of 3)5/10/2006 8:38:48 PM