Biopsy Interpretation of Pediatric Lesions

413 Pages·2014·24.95 MB·English

by  Aliya N. Husain MD

(c) 2015 Wolters Kluwer. All Rights Reserved.
BIOPSY INTERPRETATION SERIES
BIOPSY INTERPRETATION OF
PEDIATRIC LESIONS
(c) 2015 Wolters Kluwer. All Rights Reserved.
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Continue learning with all the titles
Biopsy Interpretation
in the Series.
Biopsy Interpretation of the Prostate, 5th Edition
(cid:13)(cid:148)(cid:147)(cid:134)(cid:153)(cid:141)(cid:134)(cid:147)(cid:3)(cid:12)(cid:448)(cid:3)(cid:8)(cid:149)(cid:152)(cid:153)(cid:138)(cid:142)(cid:147)(cid:3)(cid:486)(cid:3)(cid:10)(cid:138)(cid:148)(cid:151)(cid:140)(cid:138)(cid:3)(cid:13)(cid:448)(cid:3)(cid:17)(cid:138)(cid:153)(cid:153)(cid:148)
(cid:12)(cid:22)(cid:5)(cid:17)(cid:447)(cid:3)(cid:548)(cid:546)(cid:547)(cid:450)(cid:540)(cid:450)(cid:543)(cid:544)(cid:540)(cid:540)(cid:450)(cid:547)(cid:545)(cid:546)(cid:543)(cid:450)(cid:540)(cid:3)(cid:486)(cid:3)(cid:4)(cid:154)(cid:140)(cid:154)(cid:152)(cid:153)(cid:3)(cid:541)(cid:539)(cid:540)(cid:543)
Biopsy Interpretation of the Liver
(cid:16)(cid:142)(cid:136)(cid:141)(cid:134)(cid:138)(cid:145)(cid:3)(cid:23)(cid:148)(cid:151)(cid:135)(cid:138)(cid:147)(cid:152)(cid:148)(cid:147)
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Biopsy Interpretation of Soft Tissue Tumors
(cid:6)(cid:158)(cid:151)(cid:142)(cid:145)(cid:3)(cid:9)(cid:142)(cid:152)(cid:141)(cid:138)(cid:151)(cid:3)(cid:486)(cid:3)(cid:3)(cid:8)(cid:145)(cid:142)(cid:159)(cid:134)(cid:135)(cid:138)(cid:153)(cid:141)(cid:3)(cid:4)(cid:448)(cid:3)(cid:16)(cid:148)(cid:147)(cid:153)(cid:140)(cid:148)(cid:146)(cid:138)(cid:151)(cid:158)(cid:3)(cid:486)(cid:3)(cid:14)(cid:141)(cid:142)(cid:147)(cid:3)(cid:23)(cid:141)(cid:156)(cid:134)(cid:158)
(cid:12)(cid:22)(cid:5)(cid:17)(cid:447)(cid:3)(cid:548)(cid:546)(cid:547)(cid:450)(cid:539)(cid:450)(cid:546)(cid:547)(cid:540)(cid:546)(cid:450)(cid:548)(cid:544)(cid:544)(cid:548)(cid:450)(cid:542)(cid:3)(cid:486)(cid:3)(cid:17)(cid:148)(cid:155)(cid:138)(cid:146)(cid:135)(cid:138)(cid:151)(cid:3)(cid:541)(cid:539)(cid:540)(cid:539)
Biopsy Interpretation of the Bladder, 2nd Edition
(cid:13)(cid:148)(cid:147)(cid:134)(cid:153)(cid:141)(cid:134)(cid:147)(cid:3)(cid:12)(cid:448)(cid:3)(cid:8)(cid:149)(cid:152)(cid:153)(cid:138)(cid:142)(cid:147)(cid:3)(cid:486)(cid:3)(cid:16)(cid:134)(cid:141)(cid:154)(cid:145)(cid:3)(cid:5)(cid:448)(cid:3)(cid:4)(cid:146)(cid:142)(cid:147)(cid:3)(cid:486)(cid:3)(cid:25)(cid:142)(cid:136)(cid:153)(cid:148)(cid:151)(cid:3)(cid:8)(cid:448)(cid:3)(cid:21)(cid:138)(cid:154)(cid:153)(cid:138)(cid:151)
(cid:12)(cid:22)(cid:5)(cid:17)(cid:447)(cid:3)(cid:548)(cid:546)(cid:547)(cid:450)(cid:540)(cid:450)(cid:545)(cid:539)(cid:544)(cid:543)(cid:546)(cid:450)(cid:542)(cid:542)(cid:544)(cid:450)(cid:541)(cid:3)(cid:486)(cid:3)(cid:13)(cid:154)(cid:147)(cid:138)(cid:3)(cid:541)(cid:539)(cid:540)(cid:539)
Biopsy Interpretation of the Breast, 2nd Edition
(cid:22)(cid:153)(cid:154)(cid:134)(cid:151)(cid:153)(cid:3)(cid:13)(cid:448)(cid:3)(cid:22)(cid:136)(cid:141)(cid:147)(cid:142)(cid:153)(cid:153)(cid:3)(cid:486)(cid:3)(cid:15)(cid:134)(cid:154)(cid:151)(cid:134)(cid:3)(cid:6)(cid:448)(cid:3)(cid:6)(cid:148)(cid:145)(cid:145)(cid:142)(cid:147)(cid:152)
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Biopsy Interpretation of the Central Nervous
System
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(cid:12)(cid:22)(cid:5)(cid:17)(cid:447)(cid:3)(cid:548)(cid:546)(cid:547)(cid:450)(cid:539)(cid:450)(cid:546)(cid:547)(cid:540)(cid:546)(cid:450)(cid:548)(cid:548)(cid:548)(cid:542)(cid:450)(cid:544)(cid:3)(cid:486)(cid:3)(cid:16)(cid:134)(cid:158)(cid:3)(cid:541)(cid:539)(cid:540)(cid:540)
Biopsy Interpretation of the Gastrointestinal Tract
Mucosa—Volume 1: Non-Neoplastic, 2nd Edition
(cid:8)(cid:145)(cid:142)(cid:159)(cid:134)(cid:135)(cid:138)(cid:153)(cid:141)(cid:3)(cid:4)(cid:448)(cid:3)(cid:16)(cid:148)(cid:147)(cid:153)(cid:140)(cid:148)(cid:146)(cid:138)(cid:151)(cid:158)(cid:3)(cid:486)(cid:3)(cid:15)(cid:158)(cid:152)(cid:134)(cid:147)(cid:137)(cid:151)(cid:134)(cid:3)(cid:25)(cid:148)(cid:145)(cid:153)(cid:134)(cid:140)(cid:140)(cid:142)(cid:148)
(cid:12)(cid:22)(cid:5)(cid:17)(cid:447)(cid:3)(cid:548)(cid:546)(cid:547)(cid:450)(cid:540)(cid:450)(cid:543)(cid:544)(cid:540)(cid:540)(cid:450)(cid:539)(cid:548)(cid:545)(cid:539)(cid:450)(cid:542)(cid:3)(cid:486)(cid:3)(cid:17)(cid:148)(cid:155)(cid:138)(cid:146)(cid:135)(cid:138)(cid:151)(cid:3)(cid:541)(cid:539)(cid:540)(cid:540)
Biopsy Interpretation of the Gastrointestinal Tract
Mucosa—Volume 2: Neoplastic, 2nd Edition
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(cid:12)(cid:22)(cid:5)(cid:17)(cid:447)(cid:3)(cid:548)(cid:546)(cid:547)(cid:450)(cid:540)(cid:450)(cid:543)(cid:544)(cid:540)(cid:540)(cid:450)(cid:539)(cid:548)(cid:544)(cid:548)(cid:450)(cid:546)(cid:3)(cid:486)(cid:3)(cid:16)(cid:134)(cid:158)(cid:3)(cid:541)(cid:539)(cid:540)(cid:541)
Biopsy Interpretation of the Lung
(cid:22)(cid:134)(cid:154)(cid:145)(cid:3)(cid:22)(cid:154)(cid:152)(cid:153)(cid:138)(cid:151)(cid:3)(cid:486)(cid:3)(cid:6)(cid:138)(cid:152)(cid:134)(cid:151)(cid:3)(cid:4)(cid:448)(cid:3)(cid:16)(cid:148)(cid:151)(cid:134)(cid:147)
(cid:12)(cid:22)(cid:5)(cid:17)(cid:447)(cid:3)(cid:548)(cid:546)(cid:547)(cid:450)(cid:539)(cid:450)(cid:546)(cid:547)(cid:540)(cid:546)(cid:450)(cid:547)(cid:543)(cid:545)(cid:546)(cid:450)(cid:541)(cid:3)(cid:486)(cid:3)(cid:22)(cid:138)(cid:149)(cid:153)(cid:138)(cid:146)(cid:135)(cid:138)(cid:151)(cid:3)(cid:541)(cid:539)(cid:540)(cid:541)
Biopsy Interpretation of the Skin: Primary
Non-Lymphoid Neoplasms of the Skin
(cid:4)(cid:448)(cid:3)(cid:17)(cid:138)(cid:142)(cid:145)(cid:3)(cid:6)(cid:151)(cid:148)(cid:156)(cid:152)(cid:148)(cid:147)(cid:3)(cid:486)(cid:3)(cid:6)(cid:158)(cid:147)(cid:153)(cid:141)(cid:142)(cid:134)(cid:3)(cid:16)(cid:448)(cid:3)(cid:16)(cid:134)(cid:140)(cid:151)(cid:148)(cid:3)(cid:486)(cid:3)(cid:16)(cid:134)(cid:151)(cid:153)(cid:142)(cid:147)(cid:3)(cid:6)(cid:448)(cid:3)(cid:16)(cid:142)(cid:141)(cid:146)
(cid:12)(cid:22)(cid:5)(cid:17)(cid:447)(cid:3)(cid:548)(cid:546)(cid:547)(cid:450)(cid:539)(cid:450)(cid:546)(cid:547)(cid:540)(cid:546)(cid:450)(cid:546)(cid:541)(cid:539)(cid:544)(cid:450)(cid:540)(cid:3)(cid:486)(cid:3)(cid:13)(cid:154)(cid:145)(cid:158)(cid:3)(cid:541)(cid:539)(cid:540)(cid:539)
Biopsy Interpretation of the Thyroid
(cid:22)(cid:136)(cid:148)(cid:153)(cid:153)(cid:3)(cid:15)(cid:448)(cid:3)(cid:5)(cid:148)(cid:138)(cid:151)(cid:147)(cid:138)(cid:151)(cid:3)(cid:486)(cid:3)(cid:22)(cid:158)(cid:145)(cid:155)(cid:142)(cid:134)(cid:3)(cid:15)(cid:448)(cid:3)(cid:4)(cid:152)(cid:134)
(cid:12)(cid:22)(cid:5)(cid:17)(cid:447)(cid:3)(cid:548)(cid:546)(cid:547)(cid:450)(cid:539)(cid:450)(cid:546)(cid:547)(cid:540)(cid:546)(cid:450)(cid:546)(cid:541)(cid:539)(cid:543)(cid:450)(cid:543)(cid:3)(cid:486)(cid:3)(cid:17)(cid:148)(cid:155)(cid:138)(cid:146)(cid:135)(cid:138)(cid:151)(cid:3)(cid:541)(cid:539)(cid:539)(cid:548)
Biopsy Interpretation of the Upper Aerodigestive
Tract and Ear, 2nd Edition
(cid:8)(cid:137)(cid:156)(cid:134)(cid:151)(cid:137)(cid:3)(cid:5)(cid:448)(cid:3)(cid:22)(cid:153)(cid:138)(cid:145)(cid:148)(cid:156)(cid:3)(cid:3)(cid:486)(cid:3)(cid:22)(cid:153)(cid:134)(cid:136)(cid:138)(cid:158)(cid:3)(cid:8)(cid:448)(cid:3)(cid:16)(cid:142)(cid:145)(cid:145)(cid:152)
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Biopsy Interpretation: The Frozen Section,
2nd Edition
(cid:13)(cid:138)(cid:151)(cid:148)(cid:146)(cid:138)(cid:3)(cid:5)(cid:448)(cid:3)(cid:23)(cid:134)(cid:157)(cid:158)(cid:3)(cid:486)(cid:3)(cid:4)(cid:145)(cid:142)(cid:158)(cid:134)(cid:3)(cid:17)(cid:448)(cid:3)(cid:11)(cid:154)(cid:152)(cid:134)(cid:142)(cid:147)(cid:3)(cid:486)(cid:3)(cid:4)(cid:147)(cid:153)(cid:141)(cid:148)(cid:147)(cid:158)(cid:3)(cid:10)(cid:448)(cid:3)(cid:16)(cid:148)(cid:147)(cid:153)(cid:134)(cid:140)(cid:3)
(cid:12)(cid:22)(cid:5)(cid:17)(cid:447)(cid:3)(cid:548)(cid:546)(cid:547)(cid:450)(cid:540)(cid:450)(cid:543)(cid:544)(cid:540)(cid:540)(cid:450)(cid:547)(cid:545)(cid:546)(cid:548)(cid:450)(cid:545)(cid:3)(cid:486)(cid:3)(cid:7)(cid:138)(cid:136)(cid:138)(cid:146)(cid:135)(cid:138)(cid:151)(cid:3)(cid:541)(cid:539)(cid:540)(cid:542)
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BIOPSY INTERPRETATION SERIES
BIOPSY INTERPRETATION OF
PEDIATRIC LESIONS
Aliya N. Husain, MD, editor
Professor
Department of Pathology
The University of Chicago
Chicago, Illinois
(c) 2015 Wolters Kluwer. All Rights Reserved.
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Library of Congress Cataloging-in-Publication Data
Biopsy interpretation of pediatric lesions / Aliya N. Husain, editor.
p. ; cm.
Includes bibliographical references and index.
ISBN 978-1-4511-7533-2
I. Husain, Aliya N., editor of compilation.
[DNLM: 1. Biopsy—methods. 2. Adolescent. 3. Age Factors. 4. Child. 5. Diagnosis,
Differential. 6. Infant. 7. Specimen Handling. WB 379]
RB43.5
616.07'58—dc23
2014000592
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For Ameena, my first one, whose early life
experiences led me to do pediatric pathology.
For Ayesha, whose energy, enthusiasm, and
organization are inspiring.
And for Omar, who keeps us all smiling.
(c) 2015 Wolters Kluwer. All Rights Reserved.
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CONTRIBUTORS
J. Todd Boyd, DO
Associate Pathologist
Department of Pathology
Dayton Children’s Hospital
Dayton, Ohio
Allison Cavallo, MD
Resident
Department of Pathology
University of Chicago Medical Center
Chicago, Illinois
Anthony Chang, MD
Associate Professor
Department of Pathology
The University of Chicago Medicine
Chicago, Illinois
Margaret H. Collins, MD
Professor of Pathology
Department of Pathology
University of Cincinnati
Cincinnati Children’s Hospital Medical Center
Cincinnati, Ohio
Zachary D. Goodman, MD, PhD
Center for Liver Diseases and Department of Pathology
Inova Fairfax Hospital
Falls Church, Virginia
Katja Gwin, MD, PhD
Assistant Professor
Department of Pathology
University of Texas Southwestern Medical Center at Dallas
Dallas, Texas
Kammi J. Henriksen, MD
Assistant Professor
Department of Pathology
Alpert Medical School, Brown University
Providence, Rhode Island
vi
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CONTRIBUTORS ——— vii
John Hicks, MD, DDS, MS, PhD
Professor
Department of Pathology and Immunology
Baylor College of Medicine
Attending Pathologist
Department of Pathology
Texas Children’s Hospital
Houston, Texas
Haresh Mani, MD
Department of Pathology
Inova Fairfax Hospital
Falls Church, Virginia
M. Kamran Mirza, MD, PhD
Hematopathology Fellow
Department of Pathology
The University of Chicago Medicine
Chicago, Illinois
David M. Parham, MD
Professor
Department of Pathology
Keck School of Medicine
University of Southern California
Chief of Anatomic Pathology
Department of Pathology and Laboratory Medicine
Children’s Hospital of Los Angeles
Los Angeles, California
Jennifer E. Pogoriler, MD, PhD
Pediatric Pathology Fellow
Department of Pathology
Boston Children’s Hospital
Boston, Massachusetts
Peter Pytel, MD
Associate Professor
Department of Pathology
University of Chicago
Attending Pathologist
Department of Pathology
University of Chicago Medical Center
Chicago, Illinois
(c) 2015 Wolters Kluwer. All Rights Reserved.
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viii ——— CONTRIBUTORS
Vijaya B. Reddy, MD, MBA
Professor and Associate Chair of Pathology
Rush Medical College and Rush University Medical Center
Chicago, Illinois
Andrea M. Sheehan, MD
Associate Professor
Pathology and Immunology and Pediatrics
Baylor College of Medicine
Director of Hematology and Flow Cytometry
Department of Pathology
Texas Children’s Hospital
Houston, Texas
Rachel Sheridan, MD
Assistant Professor of Pathology
Pathology and Laboratory Medicine
University of Cincinnati College of Medicine
Staff pathologist
Pathology and Laboratory Medicine
Cincinnati Children’s Hospital Medical Center
Cincinnati, Ohio
J. Thomas Stocker, MD
Professor of Pathology
Pediatrics and Emerging Infectious Diseases
Department of Pathology
Uniformed Services University of the Health Sciences
Bethesda, Maryland
Karen S. Thompson, MD
Professor
Department of Pathology
John A. Burns School of Medicine, University of Hawaii
Pediatric Pathologist
Department of Pathology
Kapiolani Medical Center for Women and Children
Honolulu, Hawaii
Zhongxin Yu, MD, MSc
Assistant Professor
Department of Pathology
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma
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PREFACE
Many of the complex pediatric cases are treated in specialized children’s
hospitals; however, more and more children are first being diagnosed
at general facilities. Thus, most practicing pathologists are dealing with
pediatric specimens but not on a daily basis. Although there are some
similarities between adult and pediatric biopsies, there are also significant
differences. Many adult diseases do not or only very rarely occur in chil-
dren, whereas the common pediatric lesions are uncommon in the adult.
The spectrum of infectious organisms; types of tumors; and autoimmune,
renal, pulmonary, cutaneous, gastrointestinal, and neurologic diseases
have little overlap. The small size of the patient influences the type of
biopsy that is possible; thus, triaging the tissue and use of judicious stains
are critical.
This book addresses the common and not so common diseases that
can be diagnosed by biopsy. The differential diagnosis and use of special
techniques are emphasized. The latter include histochemical and immu-
nohistochemical stains, electron microscopic examination, and molecular
tests that one needs to do on limited samples. The appropriate tests need
to be selected in view of the clinical setting, material available, and histo-
logic findings on hematoxylin and eosin stain.
This book is organized by chapters devoted to each organ system.
Experts in their fields have written each one and provided multiple illus-
trations. Advanced trainees and diagnostic pathologists will find it helpful
to have a framework for handling pediatric biopsies in one text.
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