Table Of Content

Peptide Science Contents Volume 37, 1995 Issue 1 Editorial M. Goodman Introduction B. Merrifield 100 Years Lock-and-Key Concept: Are Peptide Keys Shaped and Guided to Their Receptors by the Target Cell Membrane? R. Schwyzer Synthesis of Large Peptides in Solution S. Sakakibara Design and Synthesis of Nonpeptide Peptidomimetic Inhibitors of Renin A. B. Smith, III, R. Akaishi, D. R. Jones, T. P. Keenan, M. C. Guzman, R. C. Holcomb, P. A. Sprengeler, J. L. Wood, M. K. Holloway, and R. Hirschmann Issue 2 Editorial A. M. Felix Design and Development of a Vasoactive Intestinal Peptide Analog as a Novel Therapeutic for Bronchial Asthma D. R. Bolin, J. Michalewsky, M. A. Wasserman, and M. O’Donnell Rational Design, Synthesis, and Biological Evaluation of Novel Growth Hormone Releasing Factor Analogues R. M. Campbell, J. Bongers, and A. M. Felix The Development of Potent Peptide Agonists and Antagonists for the Endothelin Receptors W. L. Cody and A. M. Doherty Structure-Activity Studies on Magainins and Other Host Defense Peptides W. L. Maloy and U. P. Kari Structure-Activity Relationships of Neuropeptide Y Analogues with Respect to Y, and Y, Receptors A. G. Beck-Sickinger and G. Jung Bradykinin Antagonists: Development and Applications J. M. Stewart Concept and Progress in the Development of RGD-Containing Peptide Pharmaceuticals W. S. Craig, S. Cheng, D. G. Mullen, J. Blevitt, and M. D. Pierschbacher Issue 3 177 One-Bead-One-Structure Combinatorial Libraries M. Lebl, V. Krchitdk, N. F. Sepetov, B. Seligmann, P. Strop, S. Felder, and K. S. Lam 199 The Use of Light-Directed Combinatorial Peptide Synthesis in Epitope Mapping C. P. Holmes, C. L. Adams, L. M. Kochersperger, R. B. Mortensen, and L. A. Aldwin 213 Novel Biopolymers for Drug Discovery E. J. Moran, T. E. Wilson, C. Y. Cho, S. R. Cherry, and P. G. Schultz 221 A Review of the Utility of Soluble Peptide Combinatorial Libraries C. Pinilla, J. Appel, S. Blondelle, C. Dooley, B. Dérner, J. Eichler, J. Ostresh, and R. A. Houghten Issue 4 Editorial C. Toniolo Exploring the Peptide 3,,-Helix = a-Helix Equilibrium with Double Label Electron Spin Resonance W. R. Fiori and G. L. Millhauser The Conformational Analysis of Peptides Using Fourier Transform IR Spectroscopy P. I. Haris and D. Chapman Vibrational Optical Activity of Oligopeptides T. B. Freedman, L. A. Nafie, and T. A. Keiderling The Importance of Extended Conformations and, in Particular, the P,, Conformation for the Molecular Recognition of Peptides G. Siligardi and A. F. Drake Issue 5 Editorial C. M. Deber Peptides in Membranes: Helicity and Hydrophobicity C. M. Deber and S.-C. Li Mechanism for the Modulation of Membrane Bilayer Properties by Amphipathic Helical Peptides R. M. Epand, Y. Shai, J. P. Segrest, and G. M. Anantharamaiah The Measurement of Transmembrane Helices by the Deconvolution of CD Spectra of Membrane Proteins: A Review G. D. Fasman Erratum: Concept and Progress in the Development of RGD-Containing Peptide Pharmaceuticals W. S. Craig, S. Cheng, D. G. Mullen, J. Blevitt, and M. D. Pierschbacher 365 Editorial E. Benedetti 367 Approach to Discovering Novel Therapeutic Agents for Osteoporosis Based on Integrin Receptor Blockade M. Chorev, R. Dresner-Pollak, Y. Eshel, and M. Rosenblatt Protein Structural Analysis as a Tool for Protein Design R. Leplae, A. Lahm, and A. Tramontano Two-Dimensional NMR Studies of the Interactions Between a Peptide of Cholera Toxin and Monoclonal Antibodies J. Anglister, T. Scherf, B. Zilber, and R. Levy Comparative Analysis of Various Proposed Models of the Receptor-Bound Conformation of H-Try-Tic-Phe-OH Related 6-Opioid Antagonists B. C. Wilkes and P.W. Schiller Design of Metal lon Binding Peptides R. Fattorusso, G. Morelli, A. Lombardi, F. Nastri, O. Maglio, G. D’Auria, C. Pedone, and V. Pavone The Suitability of a Monofunctional Reagent of an Undecagold Cluster for Phasing Data Collected from the Large Ribosomal Subunits from Bacillus stearothermophilus H. Bartels, W. S. Bennett, H. A. S. Hansen, M. Eisenstein, S. Weinstein, J. Miissig, N. Volkmann, F. Schliinzen, 1. Agmon, F. Franceschi, and A. Yonath Erratum: Exploring the Peptide 3,,-Helix a-Helix Equilibrium with Double Label Electron Spin Resonance W. R. Fiori and G. L. Millhauser Author Index Subject Index Volume Contents