Table Of Content

BIOPHARMACEUTICS & DRUG DISPOSITION Biopharm. Drug Dispos Contents Volume 19, Numbers 1-9 ISSUE 1 JANUARY 1998 ORIGINAL PAPERS Decomposition of Beclomethasone Propionate Esters in Human Plasma K. Foe, K. F. Brown and J. P. Seale The Effect of Chronic Retrovirus Infection and Immune Dysfunction on the p-450-Mediated Activation of Acetaminophen in Mouse Liver Microsomes H.-H. Chow, Y. Tang, P. Li, G. Brookshier, B. Liang and R. Watson . The Effect of Food on the Bioavailability of Dolasetron Mesylate Tablets C. Lippert, A. Keung, T. Arumugham, M. Eller, W. Hahne and S. Weir Comparative Bioavailability of Josamycin, a Macrolide Antibiotic, from a Tablet and Solution and the Influence of Dissolution on In Vivo Release M. Skinner and I. Kanfer Pharmacokinetics and Pharmacodynamics of Recombinant Tissue-type Plasminogen Activator Following Intravenous Administration in Rabbits: Comparison of Three Dosing Regimens S. Eppler, T. Senn, E. Gilkerson and N. B. Modi CODE: A Deconvolution Program Implementing a Regularization Method of Deconvolution Constrained to Non-Negative Values. Description and Pilot Evaluation R. Hovorka, M. J. Chappell, K. R. Godfrey, F. N. Madden, M. K. Rouse and P. A. Soons Animal Pharmacokinetics of Inogatran, a Low-Molecular-Weight Thrombin Inhibitor with Potential Use as an Antithrombotic Drug U. G. Eriksson, L. Renberg, U. Bredberg, A.-C. Teger-Nilsson and C. G. Regardh Influence of Surfactants on Oral Bioavailability of Albendazole Based on the Formation of the Sulphoxide Metabolites in Rats P. A. Redondo, A. I. Alvarez, J. L. Garcia, C. Villaverde and J. G. Prieto ISSUE 2 MARCH 1998 ORIGINAL PAPERS A Comparative Study of Ofloxacin and Ciprofloxacin Erythrocyte Distribution C. I. Colino, A. G. Turifio, A. Sanchez Navarro and J. M. Lanao Pharmacokinetic Changes of M1, M2, M3 and M4 after Intravenous Administration of a New Anthracycline, DA-125, to Rats Pretreated with Phenobarbital, 3-Methylcholanthrene, Chloramphenicol, or SKF-525A Y. J. Choi, H. J. Lee, J. W. Kwon, W. B. Kim, J. Yang and M. G. Lee Induction of Tirilazad Clearance by Phenytoin J. C. Fleishaker, L. K. Pearson and G. R. Peters No Effect of Chloroquine on Theophylline Pharmacokinetics in the Rat B. A. Motti and M. Ashton . Pharmacokinetics of a Non-Narcotic Analgesic, DA-5018, in Rats J. J. Lee, H. J. Shim, S. H. Kim, S. D. Lee, W. B. Kim, J. Yang and M. G. Lee VOLUME CONTENTS Pharmacokinetics and Haemodynamic Effect of Deacetyl Diltiazem (M,) in Rabbits after a Single Intravenous Administration P. K. F. Yeung, J. D. Z. Feng and S. J. Buckley Catalepsy Induced by Calcium Channel Blockers in Mice K. Haraguchi, K. Ito, H. Kotaki, Y. Sawada and T. Iga Pharmacokinetics and Tissue Disposition of Danofloxacin in Sheep Q. A. McKellar, I. F. Gibson and R. Z. McCormack Nonlinear Pharmacokinetics of Tissue-Type Plasminogen Activator in Three Animal Species: A Comparison of Mathematical Models K. R. Godfrey, P. Tanswell, R. A. Bates, M. J. Chappell andF . N. Madden ISSUE 3 APRIL 1998 ORIGINAL PAPERS Pharmacokinetic and Pharmacodynamic Changes of Azosemide After Intravenous and Oral Administration of Azosemide to Uranyl Nitrate-Induced Acute Renal Failure Rats K. J. Park, W. H. Yoon, S. H. Kim, W. G. Shin and M. G. Lee Pharmacokinetics and Urinary Excretion of DMXBA (GTS-21), a Compound Enhancing Cognition V. Mahnir, B. Lin, K. Prokai-Tatrai and W. R. Kem Assessment of Effect of Food, Gender and Intra-Subject Variability in the Pharmacokinetics of Avitriptan P. H. Marathe, D. S. Greene, J. S. Lee and R. H. Barbhaiya Dose-Proportional Pharmacokinetics of a New 5-Lipoxygenase Inhibitor, ABT-761, in Healthy Volunteers S. L. Wong, J. Drajesk, M. S. Chang, G. Witt and W. M. Awni The Effects of Non-Steroidal Anti-Inflammatory Drugs on the Disposition of Methotrexate in Patients with Rheumatoid Arthritis M. Perwaiz Iqbal, J. A. Baig, A. A. Ali, S. K. Niazi, N. Mehboobali and M. A. Hussain Determination of the Population Pharmacokinetic Parameters of Sustained-Release and Enteric-Coated Oral Formulations, and the Suppository Formulation of Diclofenac Sodium by Simultaneous Data Fitting Using NONMEM N. M. Idkaidek, G. L. Amidon, D. E. Smith, N. M. Najib and M. M. Hassan Grapefruit Juice and Orange Juice Effects on the Bioavailability of Nifedipine in the Rat J. S. Grundy, L. A. Eliot, K. M. Kulmatycki and R. T. Foster Pharmacokinetics and Pharmacodynamics of CI-992 Following Intravenous and Oral Administration to Cynomolgus Monkeys 1J . A. Cook, P. J. Burger, B. M. Michniewicz, G. D. Nordblom, G. W. Hicks, C. Kaplan and M. J. Ryan The Effect of Lymphatic Oedema on the Uptake of Colloids to the Lymph Nodes A. E. Hawley, L. Illum and S. S. Davis A Physiologically Based Kidney Model for the Renal Clearance of Ranitidine and the Interaction with Cimetidine and Probenecid in the Dog S. P. A. Boom, I. Meyer, A. C. Wouterse and F. G. M. Russel . VOLUME CONTENTS ISSUE 4 MAY 1998 ORIGINAL PAPERS Carrier-Mediated Intestinal Absorption of Valacyclovir, the L-Valyl Ester Prodrug of Acyclovir: 1. Interactions with Peptides, Organic Anions and Organic Cations in Rats P. J. Sinko and P. V. Balimane Pharmacokinetics and Tissue Distribution of a New Carbapenem, DA-1131, After Intravenous Administration to Mice, Rats, Rabbits and Dogs S. H. Kim, J. W. Kwon and M. G. Lee . Interspecies Pharmacokinetic Scaling of a New Carbapenem, DA-1131, in Mice, Rats, Rabbits and Dogs, and Prediction of Human Pharmacokinetics S. H. Kim, W. B. Kim and M. G. Lee The Effect of Age on the Pharmacokinetics of Valsartan A. Sioufi, F. Marfil, A. Jaouen, J. M. Cardot, J. Godbillon, F. Ezzet and P. Lloyd Artemisinin Pharmacokinetics in Healthy Adults After 250, 500 and 1000 mg Single Oral Doses M. Ashton, T. Gordi, T. Ngoc Hai, N. Van Huong, N. Duy Sy, N. Thi Nieu, D. Xuan Huong, M. Johansson and L. Dinh Cong Lack of Renal Secretion of Carbenicillin in Rats: Poor Affinity to the Organic Anion Transporter at Renal Brush Border Membrane T. Itoh, S. I. Koyano, H. Nakaura, Y. Tsuda and H. Yamada The Influence of Food on the Disposition of the Antiepileptic Rufinamide in Healthy Volunteers J.-M. Cardot, J.-B. Lecaillon, C. Czendlik and J. Godbillon Rationale for Influx Enhancement Versus Efflux Blockade to Increase Drug Exposure to the Brain P. L. Golden and G. M. Pollack SHORT COMMUNICATION Metabolic Changes of Acetaminophen After Intravenous Administration to Rats Pretreated with 2-(Allylthio)pyrazine M. K. Kwak, W. I. Lee, N. D. Kim and M. G. Lee ISSUE 5 JULY 1998 ORIGINAL PAPERS Simvastatin-Tacrolimus and Simvastatin-Cyclosporin Interactions in Rats H. Yamada, H. Kotaki, Y. Sawada and T. Iga Disposition of SDZ ENA 713, an Acetylcholinesterase Inhibitor, in the Rabbit K. Habucky and F. L. S. Tse The Influence of Moderate and Chronic Exercise Training on the Pharmacokinetics of Procainamide and N-Acetylprocainamide N. D. Eddington, F. Adekoya and J. Kharidia Beclomethasone Relative Availability of Oral versus Inhaled Beclomethasone Dipropionate from an HFA-134A Metered Dose Inhaler I. Soria, L. I. Harrison, J. H. Machacek, A. C. Cline and P. A. Stampone Pharmacokinetics of a New Carbapenem, DA-1131, after Intravenous Administration to Rats with Alloxan-Induced Diabetes Mellitus S. H. Kim, W. B. Kim and M. G. Lee VOLUME CONTENTS The Influence of Plasma Butyrylcholinesterase Concentration on the In Vitro Hydrolysis of Cocaine in Human Plasma S. P. Browne, E. A. Slaughter, R. A. Couch, E. M. Rudnic and A. M. McLean In Vitro Metabolism of 10-(3-Chlorophenyl)-6,8,9,10-Tetrahydrobenzo[b][1,8]Naphthyridin-5(7H)- One, a Topical Antipsoriatic Agent. Use of Precision-Cut Rat, Dog, Monkey and Human Liver Slices, and Chemical Synthesis of Metabolites S. Zbaida, Y. Du, D. Shannon, D. Laudicina, C. M. Thonoor, K. Ng, N. Blumenkrantz, J. E. Patrick, M. N. Cayen, R. Friary, V. Seidl, T.-M. Chan, B. Pramanik, M. Spangler and A. T. McPhail Preparation and Evaluation of Micro-Porous Ethylcellulose Capsule as Oral Sustained-Release Preparation of Theophylline Y. Yoshikawa, A. Kawai, H. Yasui, H. Yoshikawa and K. Takada Pharmacokinetics of Intravenous Luxabendazole in Rabbits: Influence of the Enterohepatic Circulation L. Alvarez-Bujidos, A. I. Ortiz, I. T. Molina-Martinez, C. Cubria and D. Orddnez ISSUE 6 SEPTEMBER 1998 EDITORIAL ORIGINAL PAPERS Pharmacokinetics of Intravenously and Orally Administered Eprosartan in Healthy Males: Absolute Bioavailability and Effect of Food D. Tenero, D. Martin, B. Ilson, J. Jushchyshyn, S. Bioke, D. Lundberg, N. Zariffa, D. Boyle and D. Jorkasky Pharmacokinetic and Pharmacodynamic Changes of Furosemide After Intravenous and Oral Administration to Rats with Alloxan-Induced Diabetes Mellitus J. H. Park, W. I. Lee, W. H. Yoon, Y.-D. Park, J.-S. Lee and M. G. Lee Steady-State Pharmacokinetics of Diltiazem and Hydrochlorothiazide Administered Alone and in Combination S. J. Weir, D. C. Dimmitt, R. C. Lanman, M. B. Morrill and D. H. Geising Blood Disposition and Urinary Excretion Kinetics of Methazolamide Following Oral Administration to Human Subjects D. R. Taft, S. Nordt, G. R. Iyer and M. H. Schwenk Evaluation of the Effect of Food on the Pharmacokinetics of Avitriptan P. H. Marathe, D. S. Greene, G. D. Kollia and R. H. Barbhaiya Uptake of Verteporfin™ by Articular Tissues Following Systemic and Intra-Articular Administration R. K. Chowdhary, L. G. Ratkay, A. J. Canaan, J. D. Waterfield, A. M. Richter and J. G. Levy Bioavailability of Morphine After Administration of a New Bioadhesive Buccal Tablet E. Beyssac, F. Touaref, M. Meyer, L. Jacob, P. Sandouk and J.-M. Aiache Chronopharmacokinetics and Calcium in the Prevention of Gentamicin-Induced Nephrotoxicity in Rabbits M. J. Perez de la Cruz, R. Cadérniga, M. C. Ochoa, I. Albarran, R. Herrero-Vanrell and P. Pastoriza Abal SHORT COMMUNICATION Blood Partition and Protein Binding of a New Reversible Proton Pump Inhibitor, YH1885 K. S. Han, Y. G. Kim,J . W. Lee and M. G. Lee ANNOUNCEMENT VOLUME CONTENTS ISSUE 7 OCTOBER 1998 ORIGINAL PAPERS Pharmacokinetics of Terbinafine and Five Known Metabolites in Children, after Oral Administration H. Humbert, J. Denouél, M. D. Cabiac, H. Lakhdar and A. Sioufi Pharmacokinetics of Single Oral and Multiple Intravenous and Oral Administration of Acebutolol Enantiomers in a Rat Model S. Abolfazl Mostafavi and R. T. Foster . Characteristic Difference in Gastrointestinal Excretion of Clarithromycin and Roxithromycin K. Arimori, S. Miyamoto, K. Fukuda, C. Nakamura and M. Nakano . Pharmacokinetic and Metabolism Studies Using Uniformly Stable Isotope Labeled Proteins with HPLC/CRIMS Detection B. L. Osborn and F. P. Abramson Physiologically Based Pharmacokinetic Prediction of p-Phenylbenzoic Acid Disposition in the Pregnant Rat M. Kawahara, T. Nanbo and A. Tsuji Dose Proportionality and Comparison of Single and Multiple Dose Pharmacokinetics of Fexofenadine (MDL 16 455) and its Enantiomers in Healthy Male Volunteers D. K. Robbins, M. A. Castles, D. J. Pack, V. O. Bhargava and S. J. Weir Physiological Mechanism-Based Analysis of Dose-Dependent Gastrointestinal Absorption of L-Carnitine in Rats K. Matsuda, H. Yuasa and J. Watanabe . Distribution of Ceftazidime in Rat Tissues L. Granero, J. Chesa-Jiménez, F. Torres-Molina and J.-E. Peris SHORT COMMUNICATION In Vitro Dissolution and Urinary Excretion Study of Metoclopramide Tablets P. A. M. Quiroga, P. M. Bustillo and M. G. Volonté LETTER TO THE EDITOR Response to the Comments on the Commentary ‘Prediction of Absolute Bioavailability for Drugs Using Oral and Renal Clearance Following a Single Oral Dose: A Critical View’ I. Mahmood ISSUE 8 NOVEMBER 1998 ORIGINAL PAPERS Pharmacokinetics and Pharmacodynamics of Mivacurium Stereoisomers in Beagle Dogs Using Twitch Height and Train-of-Four Response S. I. Lugo, Z. Liang and N. D. Eddington Pharmacokinetics of a New Reversible Proton Pump Inhibitor, YH1885, after Intravenous and Oral Administrations to Rats and Dogs: Hepatic First-pass Effect in Rats K. S. Han, Y. G. Kim, J. K. Yoo, J. W. Lee and M. G. Lee Pharmacokinetics of Minoxidil in Patients with Cirrhosis and Healthy Volunteers M. H. Adams, W. J. Poynor, W. R. Garnett, H. T. Karnes, J. J. Ferry, K. K. Ryan and M. A. Sarkar VOLUME CONTENTS Pharmacokinetic Evaluation in Dogs of Theophylline in a Novel Zero-Order Release Core-in-Cup Tablet M. P. Danckwerts, J. G. van der Watt andI . Moodley The Effect of HPMC—a Cholesterol-Lowering Agent—on Oral Drug Absorption in Dogs C. Reppas, G. Eleftheriou, P. Macheras, M. Symillides, D. Greenwood andJ . B. Dressman Pharmacokinetics of Deramciclane in Dogs after Single Oral and Intravenous Dosing and Multiple Oral Dosing H. Kanerva, H. Huuskonen, A. Alhonen-Raatesalmi, T. Nevalainen and A. Urtti Bioavailability of Dextromethorphan (as Dextrorphan) from Sustained Release Formulations in the Presence of Guaifenesin in Human Volunteers S. Demirbas, L. Reyderman and S. Stavchansky Stability of Finite Difference Deconvolution I: Theoretical Analysis J. Li and D. J. Cutler ISSUE 9 DECEMBER 1998 ORIGINAL PAPERS Experimental Equations to Calculate Aminoglycoside Clearances Through Cuprophan™ Dialyzers M. V. Mac-Kay, I. P. Fernandez, J. L. Sanchez Burson and G. F. Herrero Transdermal Absorption of Clindamycin and Tretinoin from Topically Applied Anti-Acne Formulations in Man E. J. van Hoogdalem, T. L. M. Baven, I. Spiegel-Melsen and I. J. Terpstra Brain Uptake of Dihydroergotamine After Intravenous and Nasal Administration in the Rat Y. Wang, R. Aun and F. L. S. Tse Pharmacokinetics and Tolerability of Intravenous Rizatriptan in Healthy Females Y. Lee, S. J. Ermlich, A. T. Sterrett, M. R. Goldberg, R. A. Blum, M. J. Brucker, D. A. McLoughlin, T. V. Olah, J. Zhao and J [ ) Rogers Single Dose Pharmacokinetics of HEPP, a New Anticonvulsant in Normal Healthy Volunteers D. F. Gonzalez-Esquivel, F. Rubio-Donnadieu, G. S. Carvajal and H. C. Jung Avoidance of Hepatic First-Pass Effect in the Rabbit via Rectal Route of Administration N. Kurosawa, E. Owada and K. Ito Stability of Finite Difference Deconvolution II: Simulation Studies J. Li and D. J. Cutler Intestinal Absorption and Analgesic Activity of Aminopeptidase-Resistant Cellobiose-Coupled Leucine Enkephalinamide T. Mizuma, K. Ohta and S. Awazu Author Index Key Word Index Volume Contents