Biomembranes, Singal Transduction Across Membranes PDF
Preview Biomembranes, Singal Transduction Across Membranes
Biomembranes Signal Transduction Across Membranes 4b 3 VCH Balaban Publishers Biomembranes Edited by Meir Shinitzky Volume 1: Physical Aspects, 1993 Volume 2: Structural and Functional Aspects, 1994 Volume 3: Signal Transduction Across Membranes, 1995 See page 326 for further information. 0 VCH Verlagsgesellschaft rnbH, D-69451 Weinheim (Federal Republic of Germany), 1995 Distribution: VCH, P. 0. Box 101161, D-69451 Weinheim (Federal Republic of Germany) Switzerland: VCH, P. 0. Box, CH-4020 Basel (Switzerland) United Kingdom and Ireland: VCH (UK) Ltd., 8 Wellington Court, Cambridge CB1 1HZ (England) USA and Canada: VCH, 220 East 23rd Street, New York, NY 100104606 (USA) Japan: VCH, Eikow Building, 10-9 Hongo 1-chome, Bunkyo-ku, Tokyo 113 (Japan) ISBN 3-527-30023-6 (VCH, Weinheirn) Biomembranes Signal Transduction Across Membranes Edited bv Meir Shihitzky 4b 3 VCH Balaban Publishers Weinheim . New York Basel . Cambridge . Tokyo Editor: Prof. Dr. Meir Shinitzky Department of Membrane Research and Biophysics The Weizmann Institute of Science Rehovot 76120 Israel This book was carefully produced. Nevertheless, authors, editor and publisher do not warrant the information contained therein to be free of errors. Readers are advised to keep in mind that statements, data, illustrations, procedural details or other items may inadvertently be inaccurate. Published jointly by VCH Verlagsgesellschaft mbH, Weinheim (Federal Republic of Germany) VCH Publishers Inc., New York, NY (USA) Editorial Director: Miriam Balaban Production Manager: Dip1.-Wirt.-Ing. (FH) H.-J. Schmitt Library of Congress Card No.: applied for British Library Cataloguing-in-Publication Data: A catalogue record for this book is available from the British Library Die Deutsche Bibliothek - CIP-Einheitsaufnahme Biomembranes / ed. by Meir Shinitzky. - Weinheim ; New York ; Base1 ; Cambridge ; Tokyo : VCH : Brooklyn, NY : Balaban Publ. NE: Shinitzky, Meir [Hrsg.] Vol. 3. Signal transduction across membranes. - 1995 ISBN 3-527-30023-6 0 VCH Verlagsgesellschaft mbH, D-69451 Weinheim (Federal Republic of Germany), 1995 Printed on acid-free and chlorine-free paper All rights reserved (including those of translation into other languages). No part of this book may be reproduced in any form -by photoprinting, microfilm, or any other means -nor transmitted or translat- ed into a machine language without written permission from the publishers. Registered names, trade- marks, etc. used in this book, even when not specifically marked as such are not to be considered unpro- tected by law. Printing: Strauss Offsetdruck GmbH, D-69509 Morlenbach Bookbinding: J. Schaffer, D-67269 Griinstadt Printed in the Federal Republic of Germany. Preface One of the major physiological aspects of biological membranes is signal transduction and processing. Volume 3 of this series is dedicated almost entirely to mechanisms associated with signal transduction. The unique framework of physi- cal properties presented in Volumes 1 and 2 provides an essential ground for the understanding of such mechanisms and the three volumes therefore form a com- prehensive series on membrane function. Rehovot, October 1994 Meir Shinitzky, Editor Contents Chapter 1 General Mechanistic Patterns of Signal Transduction Across Membranes . . . . . . . . . . . . . . . . . . . . . . . 1 Marcel Spaargaren, Siegfried W de Laat and Johannes Boonstra Chapter 2 Receptors for Neurotransmitters . . . . . . . . . . . . . . . 61 E Anne Stephenson and Philip G. Strange Chapter 3 Receptors to Peptide Hormones . . . . . . . . . . . . . . . 95 Sandra Incerpi and Paolo Luly Chapter 4 G Proteins in Signal Transduction . . . . . . . . . . . . . . . 153 Lutz Birnbaumer and Marie1 Birnbaumer Chapter 5 Membrane-Associated Protein Kinases and Phosphatases . . . . . 253 David S. Lester Chapter 6 Phospholipases in Signal Transduction . . . . . . . . . . . . . 283 Daniela Corda, Marco Falasca, Maria di Girolamo and Tiziana Cacciamani Index . . . . . . . . . . . . . . . . . 319 Biomemb ranes Edited by Meir Shinitzky Copyright 0 VCH Verlagsgesellschaflr nbH, 1995 CHAPTER 1 General Mechanistic Patterns of Signal Transduction Across Membranes MARCEL SPAARGARENl , SIEGFRIED W. DE LAAT2 and JOHANNES BOONSTRA3 'Onyx Pharmaceuticals, 3031 Research Drive, Bldg. A, Richmond, CA 94806, USA 2Hubrecht Luboratoty, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands 3Departrnent of Molecular Cell Biology, University of Utrecht, Padualaan 8, 3584 CH Utrecht, The Netherlands Contents 2 Abbreviations 4 Introduction 6 Receptors 8 Signal transduction 14 Cell Surface Receptors 15 Catalytic receptors 19 G-protein-coupled receptors 23 Receptors without catalytic activity or G-protein coupling 26 Signal Transduction Mechanisms 26 GTP binding/GTPase proteins 26 G-proteins 30 Ras proteins 33 Aden ylate cyclase, cyclic nucleotides and phosphodiesterases 34 Phospholipases and phospholipid-derived second messengers 34 Phospholipase A, 37 Phospholipase C 39 Phospholipase D 2 M. Spaargaren et al. 39 Kinases Protein kinase C 40 41 CAMP-dependent protein kinase 43 RAF-1 kinase 44 Mitogen-activated protein kinase 45 Signal Transduction in Development and Cancer 45 Signal transduction and development 49 Signal transduction and cancer 55 Acknowledgements 55 References Abbreviations AA - ara chi donic acid ACTH - adrenocorticotropic hormone AP - activator protein BDNF - brain-derived neurotrophic factor CAM-kinase - Ca2+/calmodulin-dependent protein kinase CRE CAMP responsive element CREB CRE binding protein CSF colony stimulating factor DG diacylgl ycerol EGF epidermal growth factor EPO erythropoietin FGF fibroblast growth factor FN fibronectin FSH follicle-stimulating hormone GAP GTPase activating protein GC guanylate cyclase G-CSF granulocyte-CSF GH growth hormone GM-CSF granulocyte-macrophage-CSF GNRP guanine nucleotide-releasing protein G-protein guanine nucleotide-binding protein HGF hepatocyte growth factor I insulin IFN interferon IGF insulin-like growth factor I1 inter leu kin inositol 1,4,5-triphosphate IP3 General Mechanistic Patterns 3 KGF - kera ti nocy te growth factor LH - luteinizing hormone LH-CG - choriogonadotropin LIF - lymphocyte inhibiting factor LPL - lysophospholipid LT - leukotriene M AP-kinase - mitogen-activated protein kinase NDF - neu differentiation factor NGF - nerve growth factor NF-1 - neurofibromatosis type-1 protein NT-3 - neurotrophin-3 PA - phosphatidic acid PAF - platelet activating factor PC - phosphatidylcholine PDE - phosphodiesterase PDGF - platelet derived growth factor PG - prostaglandin PI - phosphatidylinositol PIP - phosphatidylinositol 4-phosphate PIP, - phosphatidylinositol 4,5-bisphosphate PKA - CAMP-dependent protein kinase PKC - protein kinase C PL - phospholipid PLA, - phospholipase A, PLC - phospholipase C PLD - phospholipase D Pro - prolactin PT - pertussis toxin R - receptor RSK - ribosomal S6 kinase SCF - stem cell factor SF - steel factor SH-2 domain - src homology 2 domain TGF - transforming growth factor TNF - tumor necrosis factor TPA - 12-0-tetradecanoyl-phorbol-13-acetate TRE - TPA responsive element TRH - thyrotropin-releasing hormone TSH - thyrotropin stimulating hormone TX - thromboxane
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