Biomedical technology : modeling, experiments and simulation

356 Pages·2018·16.771 MB·English

by  Lenarz, Thomas, Wriggers, P

Lecture Notes in Applied and Computational Mechanics 84
Peter Wriggers
Thomas Lenarz Editors
Biomedical
Technology
Modeling, Experiments and Simulation
Lecture Notes in Applied and Computational
Mechanics
Volume 84
Series editors
Peter Wriggers, Leibniz Universität Hannover, Hannover, Germany
e-mail: [e-mail]
Peter Eberhard, University of Stuttgart, Stuttgart, Germany
e-mail: [e-mail]
About this Series
This series aims to report new developments in applied and computational
mechanics—quickly,informallyandatahighlevel.Thisincludesthefieldsoffluid,
solid and structural mechanics, dynamics and control, and related disciplines. The
applied methods can be of analytical, numerical and computational nature.
More information about this series at http://www.springer.com/series/4623
⋅
Peter Wriggers Thomas Lenarz
Editors
Biomedical Technology
Modeling, Experiments and Simulation
123
Editors
PeterWriggers ThomasLenarz
Institute of Continuum Mechanics Hals-Nasen-Ohrenklinik
LeibnizUniversität Hannover Medical SchoolHannover
Hannover Hannover
Germany Germany
ISSN 1613-7736 ISSN 1860-0816 (electronic)
Lecture Notesin AppliedandComputational Mechanics
ISBN978-3-319-59547-4 ISBN978-3-319-59548-1 (eBook)
DOI 10.1007/978-3-319-59548-1
LibraryofCongressControlNumber:2017941488
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Preface
A major objective of medical research is related to the development of improved
medication and implants. Due to the individual anatomy of each human being, the
researchdirectionpointsmoreandmoretowardsapatientspecificmedicine.Thisin
turnrequiresabetterunderstandingofbiologicalsystemsandoftheperformanceof
implants in humans. In engineering disciplines the application of virtual process
design has originated many important innovations. Virtual modelling helps
understand and control processes. Furthermore, virtual testing is fast and flexible.
Hence, many new products can be efficiently designed and verified by numerical
approaches.
In recent years these concepts were successfully applied in the field of
biomedical technology. Based on the tremendous advances in medical imaging,
modern CAD systems, high-performance computing and new experimental test
devices, engineering can provide a refinement of implant design and lead to safer
products. Computational tools and methods can be applied to predicting the per-
formance of medical devices in virtual patients. Physical and animal testing pro-
cedures can be reduced by use of virtual prototyping of medical devices. These
advancements enhance medical decision processes in many areas of clinical
medicine.
Inthisbook,scientistsfromdifferentareasofmedicine,engineeringandnatural
sciencesarecontributingtotheaboveresearchareasandideas.Thebookprovidesa
goodoverviewofnewmathematicalmodelsandcomputationalsimulationsaswell
as new experimental tests in the field of biomedical technology.
Inthefirstpartofthebookthevirtualenvironmentisusedinstudyingbiological
systems at different scales and under multiphysics conditions. Modelling schemes
are applied to human brain tissue, blood perfusion and metabolism in the living
human, investigation on the effect of mutations on the spectrin molecules in red
blood cells and numerical strategies to model transdermal drug delivery systems.
The second part is devoted to modelling and computational approaches in the
field of cardiovascular medicine. The contributions start with an overview of cur-
rent methods and challenges in the field of vascular haemodynamics. This is fol-
lowed by new methods to accurately predict heart flow with contact between
v
vi Preface
the leaflets, estimation of a suitable zero stress state in arterial fluid structure
interaction, solution strategies for stable partitioned fluid-structure interaction
simulations, methods for stable large eddy simulation of turbulence in cardiovas-
cular flow, a demonstration of the importance using non-Newtonian models in
specific hemodynamic cases, a multiscale modelling of artificial textile reinforced
heart valves, and new strategies to reduce the computational cost in fluid-structure
interaction modelling of haemodynamics. The part closes with a method to com-
putationally assess the rupture risk of abdominal aortic aneurysm.
A parameter study of biofilm growth based on experimental observations and
numerical test as well as a multiscale modelling approach to dental enamel are
contributions that face current challenges in dentistry.
Thepartrelatedtoorthopaedicsstartswithanoverviewofchallengesintotalhip
arthroplasty and is followed by a concept for a personalized orthopaedic trauma
surgery based on computational simulations.
The last part addresses otology and shows that an off-the-shelf pressure mea-
surement system can be successfully used for intrachochlear sound pressure
measurements. The second contribution is a user-specific method for the auditory
nerve activity, leading to a better understanding of the electrode nerve interface in
the case of cochlear implants.
All contributions highlight the state-of-the-art in biotechnology research and
thus provide an extensive overview of this subject.
Hannover, Germany Peter Wriggers
January 2017 Thomas Lenarz
Contents
Part I Biological Systems
Multiscale Aspects in the Multiphasic Modelling of Human Brain
Tissue.... .... .... .... .... ..... .... .... .... .... .... ..... .... 3
Wolfgang Ehlers and Arndt Wagner
Simulation of Steatosis Zonation in Liver Lobule—A
Continuummechanical Bi-Scale, Tri-Phasic, Multi-Component
Approach. .... .... .... .... ..... .... .... .... .... .... ..... .... 15
Tim Ricken, Navina Waschinsky and Daniel Werner
Nano-MechanicalTensileBehavioroftheSPTA1GeneinthePresence
of Hereditary Hemolytic Anemia-Related Point Mutations .. ..... .... 35
Melis Hunt
The Choice of a Performance Indicator of Release in Transdermal
Drug Delivery Systems.. .... ..... .... .... .... .... .... ..... .... 49
Giuseppe Pontrelli and Laurent Simon
Part II Cardiovascular Medicine
Multiscale Multiphysic Approaches in Vascular Hemodynamics... .... 67
Michael Neidlin, Tim A.S. Kaufmann, Ulrich Steinseifer
and Thomas Schmitz-Rode
Heart Valve Flow Computation with the Space–Time Slip Interface
Topology Change (ST-SI-TC) Method and Isogeometric Analysis
(IGA).... .... .... .... .... ..... .... .... .... .... .... ..... .... 77
Kenji Takizawa, Tayfun E. Tezduyar, Takuya Terahara
and Takafumi Sasaki
Estimation of Element-Based Zero-Stress State in Arterial FSI
Computations with Isogeometric Wall Discretization... .... ..... .... 101
Kenji Takizawa, Tayfun E. Tezduyar and Takafumi Sasaki
vii
viii Contents
Fluid-Structure Interaction Modeling in 3D Cerebral Arteries
and Aneurysms.... .... .... ..... .... .... .... .... .... ..... .... 123
Yue Yu
Large-Eddy Simulation of Turbulence in Cardiovascular Flows... .... 147
F. Nicoud, C. Chnafa, J. Siguenza, V. Zmijanovic and S. Mendez
Computational Comparison Between Newtonian and Non-Newtonian
Blood Rheologies in Stenotic Vessels.... .... .... .... .... ..... .... 169
Bruno Guerciotti and Christian Vergara
Artificial Textile Reinforced Tubular Aortic Heart Valves—Multi-
scale Modelling and Experimental Validation. .... .... .... ..... .... 185
Deepanshu Sodhani, R. Varun Raj, Jaan Simon, Stefanie Reese,
Ricardo Moreira, Valentine Gesché, Stefan Jockenhoevel, Petra Mela,
Bertram Stier and Scott E. Stapleton
Preliminary Monolithic Fluid Structure Interaction Model for
Ventricle Contraction... .... ..... .... .... .... .... .... ..... .... 217
D. Cerroni, D. Giommi, S. Manservisi and F. Mengini
The Biomechanical Rupture Risk Assessment of Abdominal Aortic
Aneurysms—Method and Clinical Relevance. .... .... .... ..... .... 233
T. Christian Gasser
Part III Dentistry
A Deeper Insight of a Multi-dimensional Continuum Biofilm
Growth Model: Experimental Observation and Parameter
Studies... .... .... .... .... ..... .... .... .... .... .... ..... .... 257
Dianlei Feng, Henryke Rath, Insa Neuweiler, Nico Stumpp,
Udo Nackenhorst and Meike Stiesch
MultiscaleExperimentalandComputationalInvestigationofNature’s
Design Principle of Hierarchies in Dental Enamel . .... .... ..... .... 273
Songyun Ma, Ingo Scheider, Ezgi D. Yilmaz, Gerold A. Schneider
and Swantje Bargmann
Part IV Orthopaedics
Challenges in Total Hip Arthroplasty... .... .... .... .... ..... .... 295
Gabriela von Lewinski and Thilo Floerkemeier
Personalized Orthopedic Trauma Surgery by Applied Clinical
Mechanics .... .... .... .... ..... .... .... .... .... .... ..... .... 313
M. Roland, T. Tjardes, T. Dahmen, P. Slusallek, B. Bouillon
and S. Diebels
Contents ix
Part V Otology
Measurement of Intracochlear Pressure Differences in Human
Temporal Bones Using an Off-the-Shelf Pressure Sensor.... ..... .... 335
Martin Grossöhmichen, Rolf Salcher, Thomas Lenarz and Hannes Maier
Development of a Parametric Model of the Electrically Stimulated
Auditory Nerve.... .... .... ..... .... .... .... .... .... ..... .... 349
Waldo Nogueira and Go Ashida