Biomedical technology : modeling, experiments and simulation PDF
Preview Biomedical technology : modeling, experiments and simulation
Lecture Notes in Applied and Computational Mechanics 84 Peter Wriggers Thomas Lenarz Editors Biomedical Technology Modeling, Experiments and Simulation Lecture Notes in Applied and Computational Mechanics Volume 84 Series editors Peter Wriggers, Leibniz Universität Hannover, Hannover, Germany e-mail: [email protected] Peter Eberhard, University of Stuttgart, Stuttgart, Germany e-mail: [email protected] About this Series This series aims to report new developments in applied and computational mechanics—quickly,informallyandatahighlevel.Thisincludesthefieldsoffluid, solid and structural mechanics, dynamics and control, and related disciplines. The applied methods can be of analytical, numerical and computational nature. More information about this series at http://www.springer.com/series/4623 ⋅ Peter Wriggers Thomas Lenarz Editors Biomedical Technology Modeling, Experiments and Simulation 123 Editors PeterWriggers ThomasLenarz Institute of Continuum Mechanics Hals-Nasen-Ohrenklinik LeibnizUniversität Hannover Medical SchoolHannover Hannover Hannover Germany Germany ISSN 1613-7736 ISSN 1860-0816 (electronic) Lecture Notesin AppliedandComputational Mechanics ISBN978-3-319-59547-4 ISBN978-3-319-59548-1 (eBook) DOI 10.1007/978-3-319-59548-1 LibraryofCongressControlNumber:2017941488 ©SpringerInternationalPublishingAG2018 Thisbookwasadvertisedwithacopyrightholder“TheEditor(s)(ifapplicable)andTheAuthor(s)”in error,whereasthepublisherholdsthecopyright. Thisworkissubjecttocopyright.AllrightsarereservedbythePublisher,whetherthewholeorpart of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission orinformationstorageandretrieval,electronicadaptation,computersoftware,orbysimilarordissimilar methodologynowknownorhereafterdeveloped. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publicationdoesnotimply,evenintheabsenceofaspecificstatement,thatsuchnamesareexemptfrom therelevantprotectivelawsandregulationsandthereforefreeforgeneraluse. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authorsortheeditorsgiveawarranty,expressorimplied,withrespecttothematerialcontainedhereinor for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictionalclaimsinpublishedmapsandinstitutionalaffiliations. Printedonacid-freepaper ThisSpringerimprintispublishedbySpringerNature TheregisteredcompanyisSpringerInternationalPublishingAG Theregisteredcompanyaddressis:Gewerbestrasse11,6330Cham,Switzerland Preface A major objective of medical research is related to the development of improved medication and implants. Due to the individual anatomy of each human being, the researchdirectionpointsmoreandmoretowardsapatientspecificmedicine.Thisin turnrequiresabetterunderstandingofbiologicalsystemsandoftheperformanceof implants in humans. In engineering disciplines the application of virtual process design has originated many important innovations. Virtual modelling helps understand and control processes. Furthermore, virtual testing is fast and flexible. Hence, many new products can be efficiently designed and verified by numerical approaches. In recent years these concepts were successfully applied in the field of biomedical technology. Based on the tremendous advances in medical imaging, modern CAD systems, high-performance computing and new experimental test devices, engineering can provide a refinement of implant design and lead to safer products. Computational tools and methods can be applied to predicting the per- formance of medical devices in virtual patients. Physical and animal testing pro- cedures can be reduced by use of virtual prototyping of medical devices. These advancements enhance medical decision processes in many areas of clinical medicine. Inthisbook,scientistsfromdifferentareasofmedicine,engineeringandnatural sciencesarecontributingtotheaboveresearchareasandideas.Thebookprovidesa goodoverviewofnewmathematicalmodelsandcomputationalsimulationsaswell as new experimental tests in the field of biomedical technology. Inthefirstpartofthebookthevirtualenvironmentisusedinstudyingbiological systems at different scales and under multiphysics conditions. Modelling schemes are applied to human brain tissue, blood perfusion and metabolism in the living human, investigation on the effect of mutations on the spectrin molecules in red blood cells and numerical strategies to model transdermal drug delivery systems. The second part is devoted to modelling and computational approaches in the field of cardiovascular medicine. The contributions start with an overview of cur- rent methods and challenges in the field of vascular haemodynamics. This is fol- lowed by new methods to accurately predict heart flow with contact between v vi Preface the leaflets, estimation of a suitable zero stress state in arterial fluid structure interaction, solution strategies for stable partitioned fluid-structure interaction simulations, methods for stable large eddy simulation of turbulence in cardiovas- cular flow, a demonstration of the importance using non-Newtonian models in specific hemodynamic cases, a multiscale modelling of artificial textile reinforced heart valves, and new strategies to reduce the computational cost in fluid-structure interaction modelling of haemodynamics. The part closes with a method to com- putationally assess the rupture risk of abdominal aortic aneurysm. A parameter study of biofilm growth based on experimental observations and numerical test as well as a multiscale modelling approach to dental enamel are contributions that face current challenges in dentistry. Thepartrelatedtoorthopaedicsstartswithanoverviewofchallengesintotalhip arthroplasty and is followed by a concept for a personalized orthopaedic trauma surgery based on computational simulations. The last part addresses otology and shows that an off-the-shelf pressure mea- surement system can be successfully used for intrachochlear sound pressure measurements. The second contribution is a user-specific method for the auditory nerve activity, leading to a better understanding of the electrode nerve interface in the case of cochlear implants. All contributions highlight the state-of-the-art in biotechnology research and thus provide an extensive overview of this subject. Hannover, Germany Peter Wriggers January 2017 Thomas Lenarz Contents Part I Biological Systems Multiscale Aspects in the Multiphasic Modelling of Human Brain Tissue.... .... .... .... .... ..... .... .... .... .... .... ..... .... 3 Wolfgang Ehlers and Arndt Wagner Simulation of Steatosis Zonation in Liver Lobule—A Continuummechanical Bi-Scale, Tri-Phasic, Multi-Component Approach. .... .... .... .... ..... .... .... .... .... .... ..... .... 15 Tim Ricken, Navina Waschinsky and Daniel Werner Nano-MechanicalTensileBehavioroftheSPTA1GeneinthePresence of Hereditary Hemolytic Anemia-Related Point Mutations .. ..... .... 35 Melis Hunt The Choice of a Performance Indicator of Release in Transdermal Drug Delivery Systems.. .... ..... .... .... .... .... .... ..... .... 49 Giuseppe Pontrelli and Laurent Simon Part II Cardiovascular Medicine Multiscale Multiphysic Approaches in Vascular Hemodynamics... .... 67 Michael Neidlin, Tim A.S. Kaufmann, Ulrich Steinseifer and Thomas Schmitz-Rode Heart Valve Flow Computation with the Space–Time Slip Interface Topology Change (ST-SI-TC) Method and Isogeometric Analysis (IGA).... .... .... .... .... ..... .... .... .... .... .... ..... .... 77 Kenji Takizawa, Tayfun E. Tezduyar, Takuya Terahara and Takafumi Sasaki Estimation of Element-Based Zero-Stress State in Arterial FSI Computations with Isogeometric Wall Discretization... .... ..... .... 101 Kenji Takizawa, Tayfun E. Tezduyar and Takafumi Sasaki vii viii Contents Fluid-Structure Interaction Modeling in 3D Cerebral Arteries and Aneurysms.... .... .... ..... .... .... .... .... .... ..... .... 123 Yue Yu Large-Eddy Simulation of Turbulence in Cardiovascular Flows... .... 147 F. Nicoud, C. Chnafa, J. Siguenza, V. Zmijanovic and S. Mendez Computational Comparison Between Newtonian and Non-Newtonian Blood Rheologies in Stenotic Vessels.... .... .... .... .... ..... .... 169 Bruno Guerciotti and Christian Vergara Artificial Textile Reinforced Tubular Aortic Heart Valves—Multi- scale Modelling and Experimental Validation. .... .... .... ..... .... 185 Deepanshu Sodhani, R. Varun Raj, Jaan Simon, Stefanie Reese, Ricardo Moreira, Valentine Gesché, Stefan Jockenhoevel, Petra Mela, Bertram Stier and Scott E. Stapleton Preliminary Monolithic Fluid Structure Interaction Model for Ventricle Contraction... .... ..... .... .... .... .... .... ..... .... 217 D. Cerroni, D. Giommi, S. Manservisi and F. Mengini The Biomechanical Rupture Risk Assessment of Abdominal Aortic Aneurysms—Method and Clinical Relevance. .... .... .... ..... .... 233 T. Christian Gasser Part III Dentistry A Deeper Insight of a Multi-dimensional Continuum Biofilm Growth Model: Experimental Observation and Parameter Studies... .... .... .... .... ..... .... .... .... .... .... ..... .... 257 Dianlei Feng, Henryke Rath, Insa Neuweiler, Nico Stumpp, Udo Nackenhorst and Meike Stiesch MultiscaleExperimentalandComputationalInvestigationofNature’s Design Principle of Hierarchies in Dental Enamel . .... .... ..... .... 273 Songyun Ma, Ingo Scheider, Ezgi D. Yilmaz, Gerold A. Schneider and Swantje Bargmann Part IV Orthopaedics Challenges in Total Hip Arthroplasty... .... .... .... .... ..... .... 295 Gabriela von Lewinski and Thilo Floerkemeier Personalized Orthopedic Trauma Surgery by Applied Clinical Mechanics .... .... .... .... ..... .... .... .... .... .... ..... .... 313 M. Roland, T. Tjardes, T. Dahmen, P. Slusallek, B. Bouillon and S. Diebels Contents ix Part V Otology Measurement of Intracochlear Pressure Differences in Human Temporal Bones Using an Off-the-Shelf Pressure Sensor.... ..... .... 335 Martin Grossöhmichen, Rolf Salcher, Thomas Lenarz and Hannes Maier Development of a Parametric Model of the Electrically Stimulated Auditory Nerve.... .... .... ..... .... .... .... .... .... ..... .... 349 Waldo Nogueira and Go Ashida
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