Table Of Content

Biomedical Photonics for Diabetes Research In 2021, over 537 million people worldwide were diagnosed with diabetes, according to the International Diabetes Federation, and so the diagnosis, care, and treatment of patients with diabetes mellitus have become one of the highest healthcare priorities. Biomedical photonics methods have been found to significantly improve and assist in the diagnosis of various disorders and complications arising from diabetes. These methods have also been widely used in various studies in the field of diabetes, including in the assessment of biochemical characteristics, metabolic processes, and microcirculation that are impaired in this disease. This book provides an introduction to methods of biomedical photonics. The chapters, written by w orld-leading experts, cover a wide range of issues, including the theoretical basis of different biophotonics methods and practical issues concerning the conduction of experimental studies to diagnose disorders associated with diabetes. It provides a comprehensive summary of the recent advances in biomedical optics and photonics in the study of diabetes and related complications. This book will be of interest to biomedical physicists and researchers, in addition to practicing doctors and endocrinologists looking to explore new instrumental methods for monitoring the effec- tiveness of patient treatment. Features • The first collective book combining accumulated knowledge and experience in the field of diabetes research using biophotonics. • Contributions from leading experts in the field. • Combines the theoretical base of the described methods and approaches, as well as provid- ing valuable practical guidance and the latest research from experimental studies. Series in Medical Physics and Biomedical Engineering Series Editors Kwan-Hoong Ng, E. Russell Ritenour, and Slavik Tabakov RECENT BOOKS IN THE SERIES: Auto-Segmentation for Radiation Oncology: State of the Art Jinzhong Yang, Gregory C. Sharp, and Mark Gooding Clinical Nuclear Medicine Physics with MATLAB: A Problem Solving Approach Maria Lyra Georgosopoulou (Ed) Handbook of Nuclear Medicine and Molecular Imaging for Physicists – Three Volume Set Volume I: Instrumentation and Imaging Procedures Michael Ljungberg (Ed) Practical Biomedical Signal Analysis Using MATLAB® Katarzyna J. Blinowska and Jaroslaw Zygierewicz Handbook of Nuclear Medicine and Molecular Imaging for Physicists – Three Volume Set Volume II: Modelling, Dosimetry and Radiation Protection Michael Ljungberg (Ed) Handbook of Nuclear Medicine and Molecular Imaging for Physicists – Three Volume Set Volume III: Radiopharmaceuticals and Clinical Applications Michael Ljungberg (Ed) Electrical Impedance Tomography: Methods, History and Applications, Second Edition David Holder and Andy Adler (Eds) Introduction to Medical Physics Cornelius Lewis, Stephen Keevil, Anthony Greener, Slavik Tabakov, and Renato Padovani Calculating X-ray Tube Spectra: Analytical and Monte Carlo Approaches Gavin Poludniowski, Artur Omar, and Pedro Andreo Problems and Solutions in Medical Physics: Radiotherapy Physics Kwan-Hoong Ng, Ngie Min Ung, and Robin Hill Biomedical Photonics for Diabetes Research Andrey V. Dunaev and Valery V. Tuchin (Eds) For more information about this series, please visit: https://www.routledge.com/Series-in-Medical- Physics-and-Biomedical-Engineering/book-series/CHMEPHBIOENG Biomedical Photonics for Diabetes Research Edited by Andrey V. Dunaev and Valery V. Tuchin First edition published 2023 by CRC Press 4 Park Square, Milton Park, Abingdon, Oxon, OX14 4RN and by CRC Press 6000 Broken Sound Parkway NW, Suite 300, Boca Raton, FL 33487-2742 © 2023 selection and editorial matter, Andrey V. Dunaev and Valery V. Tuchin; individual chapters, the contributors CRC Press is an imprint of Taylor & Francis Group, LLC Reasonable efforts have been made to publish reliable data and information, but the author and publisher cannot assume responsibility for the validity of all materials or the consequences of their use. 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For works that are not available on CCC please contact [email protected] Trademark notice: Product or corporate names may be trademarks or registered trademarks and are used only for identification and explanation without intent to infringe. ISBN: 978-0-367-62830-7 (hbk) ISBN: 978-0-367-63091-1 (pbk) ISBN: 978-1-003-11209-9 (ebk) DOI: 10.1201/9781003112099 Typeset in Times by codeMantra Contents Editors ..............................................................................................................................................vii Contributors ......................................................................................................................................ix Introduction ....................................................................................................................................xiii Andrey V. Dunaev and Valery V. Tuchin Chapter 1 Optical and Structural Properties of Biological Tissues under Simulated Diabetes Mellitus Conditions .......................................................................................1 Daria K. Tuchina, Alla B. Bucharskaya, Polina A. Dyachenko ( Timoshina), Nataliya I. Dikht, Georgy S. Terentyuk, and Valery V. Tuchin Chapter 2 Optical Methods for Diabetic Foot Ulcer Screening .................................................33 Robert Bartlett, Gennadi Saiko, and Alexandre Yu. Douplik Chapter 3 The Use of Capillaroscopy and Aggregometry Methods to Diagnose the Alterations of Microcirculation and Microrheology in Diabetes ...............................57 Andrei E. Lugovtsov, Yury I. Gurfinkel, Petr B. Ermolinskiy, Anastasia A. Fabrichnova, and Alexander V. Priezzhev Chapter 4 Diagnostics of Functional Abnormalities in the Microcirculation System Using Laser Doppler Flowmetry ................................................................................81 Irina A. Mizeva, Elena V. Potapova, and Elena V. Zharkikh Chapter 5 Wearable Sensors for Blood Perfusion Monitoring in Patients with Diabetes Mellitus .....................................................................................................107 Evgenii A. Zherebtsov, Elena V. Zharkikh, Yulia I. Loktionova, Angelina I. Zherebtsova, Viktor V. Sidorov, Alexander I. Krupatkin, and Andrey V. Dunaev Chapter 6 Optical Angiography at Diabetes .............................................................................137 Dan Zhu, Jingtan Zhu, Dongyu Li, Tingting Yu, Wei Feng, and Rui Shi Chapter 7 Noninvasive Sensing of Serum sRAGE and Glycated Hemoglobin by Skin UV-Induced Fluorescence ...............................................................................155 Vladimir V. Salmin, Tatyana E. Taranushenko, Natalya G. Kiseleva, and Alla B. Salmina Chapter 8 Hyperspectral Imaging of Diabetes Mellitus Skin Complications ..........................177 Viktor V. Dremin, Evgenii A. Zherebtsov, Alexey P. Popov, Igor V. Meglinski, and Alexander V. Bykov v vi Contents Chapter 9 Fluorescent Technology in the Assessment of Metabolic Disorders in Diabetes ....197 Elena V. Zharkikh, Viktor V. Dremin, and Andrey V. Dunaev Chapter 10 Terahertz Time-Domain Spectroscopy in the Assessment of Diabetic Complications ...........................................................................................................213 Sviatoslav I. Gusev, Ravshanjon Kh. Nazarov, Petr S. Demchenko, Tianmiao Zhang, Olga P. Cherkasova, and Mikhail K. Khodzitsky Chapter 11 Noninvasive Photonic Sensing of Glucose in Bloodstream .....................................239 Nisan Ozana and Zeev Zalevsky Index ..............................................................................................................................................255 Editors Andrey V. Dunaev is a Professor and a Leading Researcher at the Research and Development Center of Biomedical Photonics at Orel State University ( Orel, Russia). His research interests are devoted to multimodal optical diagnostics of microcirculatory-tissue systems, including method- ological and metrological support of diagnostic systems. He is a senior member of SPIE. Professor Dunaev is an Honorary Worker of Science and High Technologies of the Russian Federation. He is an author of more than 100 papers in p eer-reviewed journals, 5 monographs and has over 10 patents. Valery V. Tuchin i s a Corresponding Member of the Russian Academy of Sciences, Professor, Head of the Department of Optics and Biophotonics and Director of the Science Medical Center of Saratov State University. He is also Head of the Laboratory for Laser Diagnostics of Technical and Living Systems at the Institute of Precision Mechanics and Control, FRC “ Saratov Scientific Center of the Russian Academy of Sciences.” His research interests include biophotonics, biomedical optics, tissue optics, laser medicine, tissue optical clearing, and nanobiophotonics. He is a member of SPIE, OSA, and IEEE, Visiting Professor at HUST ( Wuhan) and Tianjin Universities in China, and an Adjunct Professor at the University of Limerick ( Ireland) and the National University of Ireland ( Galway). Professor Tuchin is elected Fellow SPIE and OSA ( OPTICA), he was awarded many titles and awards, including Honored Scientist of the Russian Federation, Honored Professor of SSU, Honored Professor of Finland ( FiDiPro), SPIE Educational Award, Chime Bell Award of Hubei province ( China), Joseph Goodman Award ( OSA / SPIE) for Outstanding Monograph ( 2015), Michael Feld Award ( OSA) for Pioneering Research in Biophotonics ( 2019), the Medal of the D.S. Rozhdestvensky Optical Society ( 2018) and the A.M. Prokhorov medal of the Academy of Engineering Sciences named after A.M. Prokhorov ( 2021). He is the author of over 1000 articles, 30 monographs, and textbooks, has over 60 patents, his works have been cited over 34,500 times. vii Contributors Robert Bartlett Viktor V. Dremin Swift Medical Inc. College of Engineering and Toronto, Canada Physical Sciences Aston University Alla B. Bucharskaya Birmingham, UK Science Medical Center and Saratov State University Research and Development Center of Saratov, Russia Biomedical Photonics and Orel State University Laboratory of Laser Molecular Imaging and Orel, Russia Machine Learning Tomsk State University Andrey V. Dunaev Tomsk, Russia Research and Development Center of and Biomedical Photonics Saratov State Medical University Orel State University Saratov, Russia Orel, Russia Alexander V. Bykov Polina A. Dyachenko Opto-Electronics and Measurement Techniques (T imoshina) Unit Science Medical Center University of Oulu Saratov State University Oulu, Finland Saratov, Russia and Olga P. Cherkasova Laboratory of Laser Molecular Biophysics laboratory Imaging and Machine Institute of Laser Physics of SB RAS Learning Novosibirsk, Russia Tomsk State University Tomsk, Russia Petr S. Demchenko Terahertz Biomedicine Laboratory Petr B. Ermolinskiy ITMO University Physics Department St. Petersburg, Russia Lomonosov Moscow State University Nataliya I. Dikht Moscow, Russia Saratov State Medical University Saratov, Russia Anastasia A. Fabrichnova Faculty of Fundamental Medicine Alexandre Yu. Douplik Lomonosov Moscow Department of Physics State University Ryerson University Moscow, Russia Toronto, Canada and iBest, Keenan Research Centre of the LKS Knowledge Institute St. Michael’s Hospital Toronto, Canada ix