Biology of Parasitism PDF
Preview Biology of Parasitism
BIOLOGY OF PARASITISM edited Ьу Christian Tschudi Department of Intemal Medicine у ale University School of Medicine New Haven, Connecticut and Edward J. Pearce Department ofMicrobiology and Immunology СотеН University Ithaca, New У ork SPRINGER SCIENCE+BUSINESS MEDIA, LLC Dedicated to TS Library of Congress Саtаlоgiпg-iп-РubIiсаtiоп Data Biology ofparasitism / edited Ьу Christian Tschudi and Edward J. Pearce. р. ст. Il1cludes bibIiographical referel1ces and il1dex. ISBN 978-1-4419-4977-6 ISBN 978-1-4757-4622-8 (eBook) DOI 10.1007/978-1-4757-4622-8 1. Parasitic diseases. 2. Parasitism. 3. Molecular parasitology. 1. Tschudi, Christian, 1954-11. Pearce, Edward J., 1958- QR201.P27 В55 2000 616.9'6-dc21 00-025365 Copyright@ 2000 Ьу Spril1ger Sciel1ce+Business Media New York Originally pubIished Ьу К1uwег Academic PubIishers il1 2000 АН rights reserved. No part of this pubIication тау Ье reproduced, stored in а retrieval system or transmitted in anу [оnn or Ьу anу means, mechanical, photo-copying, recording, or otherwise, without the prior written pennission of the pubIisher, Springer Science+Business Media, LLC. Printed оп acid-free рарег. Photo credit: the cover photo shows а common deer tick Ьу Monica Oli, а student ofthe 1998 Biology ofParasitism course. CONTENTS Contributors ................................................................... ix Preface Christian Tschudi and Edward J. Pearce . . . . . . . . . . . . . . .. . . . . .... . . . . .... . . . . .. xv Foreword John R. David ..................................................................... xvii MOLECULAR BIOLOIGY 1 Import ofNuclear Encoded tRNA into Mitochondria Audra Е. Уеnnоvsky-Кашmеrеr and Stephen L. Hajduk 1 2 RNA Metabolism in Trypanosomes: Approaches to Unravel pre-mRNА Signals Required for Intron Removal Christian Tschudi and Elisabetta Ullu ................................. 19 3 Stable Transfection of Plasmodium berghei: А Crash Course Andrew Р. Waters . . . . . . . . . . . . . . . . . . . . . . . .. . .. . . . . . . . . . . . . . . . . . . . . . . ..... . . 43 BIOCHEMISTRY 4 Malaria Chemotherapy: Paradigms from Pyrimidine Metabolism Pradipsinh К. Rathod .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ..... . . . . ... 73 vi 5 Polyamine and Glutathione Biosynthetic Enzymes Crom Trypanosoтa brucei and Trypanosoтa cruzi Lisa N. Kineh, Deirdre L. Brekken, and Margaret А. Phi1lips 95 6 Acetylcholinesterases оС Gastrointestinal Nematodes Murray Е. Selkirk and Аyrnап S. Hussein ........................... 121 CELL BIOLOGY 7 Toxoplasтa as а Model Apicomplexan Parasite: Biochemistry, Сеll Вiology, Molecular Genetics, Genomics and Beyond David S. Roos, John А. Darling, Mary а. Reynolds, Кristin М. Hager, Boris Striepen and Jessiea С. Kissinger .... ... ..... .... ...... 143 8 The Trichomonad Hydrogenosome Sabrina D. Dyall and Patricia J. Johnson 169 9 Lysosome Exocytosis and Invasion оС Non-Phagocytic Host Cells Ьу Trypanosoтa cruzi Barbara А. Burleigh ........ '" .................. ,. . . .. ... .. ... ... . .. .... 195 10 Сеll Biological Approaches to the Study оС Intracellular Pathogens: Motility, Invasion, Secretion and Vesicular Trafficking David а. Russell, Dana а. Mordue, Wandy Beatty, Olivia К. Giddings, Jennie L. Lovett, Andreas Lingnau, Maren Lingnau, Jaime Dant and L. David Sibley ....................................... 213 IMMUNOLOGY 11 Cytokine Regulation оС Filaria: Induced Airway and Corneal Disease Erie Pearlman, Rajeev К. Meh1otra, Musa А. Haxhiu and Laurie R. НаН . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 255 12 Molecular Mechanisms оС Granuloma Formation in Schistosomiasis Stephen J. Davies and James Н. MeKerrow ........................ 273 vii 13 Experimental Approaches to Studying the Immunology of Parasitic Diseases Edward J. Pearce and Phi1lip Scott ... .... .... ..... ... ... ... ...... ..... 291 Appendix Participants in the Biology of Parasitism Course 1998 320 Participants in the Biology ofParasitism Course 1999 321 Index ........................................................................... 323 CONTRIBUTORS Wandy Beatty Jaime Dant Department ofMolecular Department ofMolecular Microbiology Microbiology Washington University Washington University 660 South Euclid А venue St. Louis, МО 63110-1093 St. Louis, МО 63110-1093 John А. Darling Deirdre L. Brekken Department ofBiology University of Texas Southwest U niversity of Pennsylvania Department of Рhапnасоlоgy 415 South University А уепuе 5323 Напу Hine Blvd. Philadelphia, Р А 19104-6018 Dallas, ТХ 75235-9341 John R. David Barbara А. Burleigh Harvard School ofPublic Health Department of Immunology and 665 Huntington А venue Infectious Diseases Boston, МА 02115 Harvard School ofPublic Health Building 1, Rm 713 Stephen J. Davies 665 Huntington А venue Department ofPathology Boston, МА 02115 UCSF Tropical Disease Research [email protected] Unit 4150 Clement Street- 113В San Francisco, СА 94121 х Sabrina D. DyaH Musa А. НахЫи UCLA Microbiology and Division of Geographic Medicine Immunology Case Westem Reserve University 1602 Molecular Sciences Bldg. School ofMedicine, W137 405 Hilgard А уе. 2109 Adelbert Rd Los Angeles, СА 90095-1489 Cleveland, ОН 44106 Olivia К. Giddings Аутап S. Hussein Department of Molecular Imperial College of Science, Microbiology Technology and Medicine Washington University Department of Biochemistry School of Medicine London SW7 2А У, UK 660 South Euclid А уепие St. Louis, МО 63110-1093 Patricia J. Johnson UCLA Microbiology and Kristin М. Hager Immunology Department ofBiology 1602 Molecular Sciences Bldg. University ofPennsylvania 405 Hilgard А уе. Goddard Laboratories Los Angeles, СА 90095-1489 415 South University Ауепие [email protected] Philadelphia, Р А 19104-6018 Lisa N. КiпсЬ Stephen L. Hajduk University ofTexas Southwest Department of Biochemistry and Department of Pharmacology Molecular Genetics 5323 Harry Hine Blvd. University of АlаЬаmа at Dallas, ТХ 75235-9341 Birmingham 1918 University Blvd. Jessica С. Kissinger Birmingham, AL 35294 Departrnent ofBiology [email protected] University of Pennsylvania 415 South University А уепие Laurie R. НаН Philadelphia, Р А 19104-6018 Division of Geographic Medicine Case Westem Reserve University Andreas Lingnau School ofMedicine, W137 Department ofMolecular 2109 Adelbert Rd Microbiology Cleveland, ОН 44106 Washington University School of Medicine 660 South Euclid А уепие St. Louis, МО 63110-1093 xi Maren Lingnau Edward J. Pearce Department ofMolecular Department ofMicrobiology and Microbiology Immunology Washington University CoHege of Veterinary Medicine School of Medicine Соmеll University 660 South Euclid А уепие Schuman НаН Room С320 St. Louis, МО 63110-1093 Ithaca, NY 14853-6401 [email protected] Jennie L. Lovett Department ofMolecular Eric Pearlman Microbiology Division of Geographic Medicine Washington University Case Westem Reserve University SchoolofMedicine School ofMedicine, W137 660 South Euclid А уепие 2109 Adelbert Rd St. Louis, МО 63110-1093 Cleveland, ОН 44106 [email protected] James Н. McKerrow Department of Pathology Margaret А. РhШiрs UCSF Tropical Disease Research University ofTexas Southwest Unit Department ofPharmacology 4150 Clement Street- 113В 5323 Harry Нine Blvd. San Francisco, СА 94121 Dallas, ТХ 75235-9341 [email protected] phillipO [email protected] Raj ееу К. Mehlotra Pradipsinh К. Rathod Division of Geographic Medicine The Catholic University of Case Westem Reserve University America School ofMedicine, W137 Department of Biology 2109 Adelbert Rd 620 Michigan Ауепие, NE Cleveland, ОН 44106 Washington, DC 20064 [email protected] Dana G. Mordue Department ofMolecular Mary G. Reynolds Microbiology Department ofBiology Washington University University ofPennsylvania SchoolofMedicine Goddard Laboratories 660 South Euclid А уепие 415 South University Ауепие St. Louis, МО 63110-1093 Philadelphia, Р А 19104-6018 хи David S. Roos L. David Sibley Department of Biology Department of Molecular University ofPennsylvania Microbiology Goddard Laboratories Washington University 415 South University Avenue School of Medicine Philadelphia, Р А 19104-6018 660 South Euclid А venue [email protected] St. Louis, МО 63110-1093 [email protected] David G. Russell Department of Molecular Boris Striepen Microbiology Department of Biology Washington University University ofPennsylvania School of Medicine 415 South University Avenue 660 South Euclid А venue Philadelphia, Р А 19104-6018 St. Louis, МО 63110-1093 [email protected] Christian Tschudi Department of Intemal Medicine Phillip Scott Уаlе University, School of University ofPennsylvania Medicine The School of Veterinary Р.О. Вох 208022 Medicine New Haven, СТ 06520-8022 Department of Pathobiology [email protected] 3800 Spruce Street Philadelphia, Р А 19104-6008 Elisabetta Ullu [email protected] Department of Intemal Medicine Yale University, School of Murray Е. Selkirk Medicine Imperial College of Science, Р.О. Вох 208022 Technology and Medicine New Haven, СТ 06520-8022 Department ofBiochemistry elisabetta. [email protected] Prince Consort Road London SW7 2АУ, ик [email protected]
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