Biology and Chemistry of Eukaryotic Cell Surfaces PDF
Preview Biology and Chemistry of Eukaryotic Cell Surfaces
minmi uimTER svmposm 1. W. J. Wheian and J. Schultz, editors. HOMOLOGIES IN ENZYMES AND META- BOLIC PATHWAYS and METABOLIC ALTERATIONS IN CANCER,* 1970 2. D. W. Ribbons, J. F. Woessner, Jr., and J. Schultz, editors-. NUCLEIC ACID-PROTEIN INTERACTIONS and NUCLEIC ACID SYNTHESIS IN VIRAL INFECTION,* 1971 3. J.F. Woessner, Jr. and F. Huijing, editors: THE MOLECULAR BASIS OF BIOLOGICAL TRANSPORT, 1972 4. J. Schultz and B. F. Cameron, editors·. THE MOLECULAR BASIS OF ELECTRON TRANSPORT, 1 972 5. F. Huijing and E. Y. C. Lee, editors·. PROTEIN PHOSPHORYLATION IN CON- TROL MECHANISMS, 1973 6. J. Schultz and H. G. Gratzner, editors·. THE ROLE OF CYCLIC NUCLEOTIDES IN CARCINOGENESIS, 1973 7. E. Y. C. Lee and E. E. Smith, editors·. BIOLOGY AND CHEMISTRY OF EUCARYOTIC CELL SURFACES, 1974 8. J. Schultz and R. Block, editors·. MEMBRANE TRANSFORMATION IN NEOPLASIA, 1974 Published by North-Holland Publishing Company, Amsterdam, The Netherlands. minmi uiinTER svmposin-voiumE 7 Biology and Chemistry of Eucaryotic Cell Surfaces edited by E. V. I. Lee E. E. Smith DEPARTMENT OF BIOCHEMISTRY UNIVERSITY OF MIAMI SCHOOL OF MEDICINE MIAMI, FLORIDA Proceedings of the Miami Winter Symposia, January 14- 15, 1974 organized by the Department of Biochemistry, University of Miami School of Medicine, Miami, Florida ACADEMIC PRESS New York and London 1974 A Subsidiary of Harcourt Brace Jovanovich, Publishers COPYRIGHT © 1974, BY ACADEMIC PRESS, INC. ALL RIGHTS RESERVED. NO PART OF THIS PUBLICATION MAY BE REPRODUCED OR TRANSMITTED IN ANY FORM OR BY ANY MEANS, ELECTRONIC OR MECHANICAL, INCLUDING PHOTOCOPY, RECORDING, OR ANY INFORMATION STORAGE AND RETRIEVAL SYSTEM, WITHOUT PERMISSION IN WRITING FROM THE PUBLISHER. ACADEMIC PRESS, INC. Ill Fifth Avenue, New York, New York 10003 United Kingdom Edition published by ACADEMIC PRESS, INC. (LONDON) LTD. 24/28 Oval Road, London NW1 Library of Congress Cataloging in Publication Data Main entry under title: Biology and chemistry of eucaryotic cell surfaces. (Miami winter symposia, v. 7) "Proceedings of the Miami winter symposia, January 14-15, 1974, organized by the Department of Biochemistry, University of Miami School of Medicine, Miami, Florida." 1. Cell membranes—Congresses. 2. Cytochemistry- Congresses. I. Lee, Ernest Yee Chung, ed. II. Smith, Eric Ernest, Date ed. III. Miami, University of, Coral Cables, Fla. Dept. of Biochemistry. IV. Series. [DNLM: 1. Cell membrane-Congresses. 2. Cell nucleus-Congresses. W3M1202v. 7 1974 / WH595 S989b 1974] QH601.B525 574.8'75 74-10683 ISBN 0-12-441550-4 PRINTED IN THE UNITED STATES OF AMERICA SPEAKERS, CHAIRMEN, AND DISCUSSANTS Ankel, H., The Medical College of Wisconsin, Milwaukee, Wisconsin Assaf, S. A., University of Texas Medical School, Houston, Texas Basu, S., University of Notre Dame, Notre Dame, Indiana Behrens, N. H., Instituto de Investigaciones Bioquimicas, Buenos Aires, Argentina Bernacki, R., Roswell Park Memorial Institute, Buffalo, New York Bhattacharyya, S., Duke University Medical Center, Durham, North Carolina Boone, C, National Institutes of Health, Bethesda, Maryland Bretthauer, R. K., University of Notre Dame, Notre Dame, Indiana Christopher, C. W., Harvard Medical School, Boston, Massachusetts Czech, M. P., Duke University Medical Center, Durham, North Carolina Daniel, J., Papanicolaou Cancer Institute, University of Miami, Miami, Florida DeLuca, L., National Institutes of Health, Bethesda, Maryland Elbein, A. D., University of Texas Health Science Center, San Antonio, Texas Fullerton, W. W., Merck Institute for Therapeutic Research, West Point, Pennsylvania Gardner, D. A., Miles Laboratories, Inc., Elkhart, Indiana Gerisch, G., Friedrich-Miescher-Laboratorium des Max Planck Gesellschaft, Tübingen, Germany Ginsburg, V., National Institute of Arthritis and Metabolic Disorders, Bethesda, Maryland ix SPEAKERS, CHAIRMEN, AND DISCUSSANTS Glick, M. C, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania Goldstein, J., New York Blood Center, New York, New York Hakomori, S., University of Washington, Seattle, Washington Heath, E. C, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania Hempling, H. G., Medical University of S. Carolina, Charleston, South Carolina Hochstadt, J., Worcester Foundation for Experimental Biology, Shrewsbury, Massachusetts Horowitz, M., New York Medical College, Valhalla, New York Huijing, F., (Session Chairman), University of Miami School of Medicine, Miami, Florida Jamieson, G. A., The American National Red Cross Blood Research Laboratory, Bethesda, Maryland Jeanloz, R. W., Harvard Medical School, Boston, Massachusetts Kalos, J., Columbia University, New York, New York Keston, A., Institute for Medical Research and Studies, New York, New York Koch, G., Roche Institute of Molecular Biology, Nutley, New Jersey Kornfeld, S. A., Washington University, St. Louis, Missouri Leloir, L. F., (Session Chairman), Instituto de Investigaciones Bioquimicas, Buenos Aires, Argentina Longton, R., National Naval Medical Center, Bethesda, Maryland Lubin, M., Dartmouth Medical School, Hanover, New Hampshire Lynen, F., (Session Chairman), Max-Planck Institut für Biochemie, Munich, Germany Marchesi, V. T., Yale University, New Haven, Connecticut Montes de Gomez, V., National University of Colombia, Bogota, Colombia x SPEAKERS, CHAIRMEN, AND DISCUSSANTS Morrison, M., St. Jude Children's Research Hospital, Memphis, Tennessee Nathenson, S. G., Albert Einstein College of Medicine, New York, New York Nicolson, G. L., The Salk Institute for Biological Studies, San Diego, California Ostrand-Rosenberg, S., California Institute of Technology, Pasadena, California Pickart, L. R., University of California, San Francisco, California Poretz, R. D., Rutgers University, New Brunswick, New Jersey Quash, G., University of the West Indies, Kingston, Jamaica Rabinowitz, M., National Institutes of Health, Bethesda, Maryland Reddi, A. H., University of Chicago, Chicago, Illinois Reinhold, V. N., Arthur D. Little, Inc., Cambridge, Massachusetts Rieber, M., Center of Microbiology and Cell Biology, Caracas, Venezuela Robbins, P. W., Massachusetts Institute of Technology, Cambridge, Massachusetts Roseman, S., John Hopkins University, Baltimore, Maryland Rosenberg, S., (see S. Ostrand-Rosenberg) Roth, J., Biocenter, Basel, Switzerland Schenkein, L, New York University Medical Center, New York, New York Srere, P. A., Veterans Administration Hospital, Dallas, Texas Stanford, H. K., (Session Chairman), President, University of Miami, Coral Gables, Florida Sutherland, E. W., (Session Chairman), University of Miami School of Medicine, Miami, Florida Vaheri, A., University of Helsinki, Helsinki, Finland Warren, L., University of Pennsylvania, Philadelphia, Pennsylvania xi SPEAKERS, CHAIRMEN, AND DISCUSSANTS Whelan, W. /., Chairman, Department of Biochemistry, University of Miami School of Medicine, Miami, Florida Wolff /., National Institutes of Health, Bethesda, Maryland Wood, H. G., (Session Chairman), Case Western Reserve University, Cleveland, Ohio PREFACE In January 1969, the Department of Biochemistry of the University of Miami and the University-affiliated Papanicolaou Cancer Research Institute joined in sponsoring and presenting two symposia on biochemical topics. Those symposia have now developed into an annual event, now in its sixth year. In 1970 the two symposia were published as the first volume of a continuing series entitled the "Miami Winter Symposia." In 1972 we initiated the publication of the proceedings of the two symposia as separate volumes in the series. The major emphasis in the selection of the topics for our symposia has been to identify the frontier areas in which progress in biochemistry is leading toward an understanding of the molecular bases of biological pheno- mena. We follow a pattern in which a common theme is dealt with, in our symposium, on a fundamental basis, and then in the Papanicolaou Cancer Research Institute Symposium, as it relates to an understanding of malignant processes. This volume, the seventh in the series, contains the proceedings of the Biochemistry Department's Symposium on the "Biology and Chemistry of Eucaryotic Cell Surfaces," and will be published simultaneously with the proceedings of the Papanicolaou Cancer Research Institute's symposium on "Membrane Transformations in Neoplasia." In 1975 the topics for the symposium will be on a theme in basic immunology followed by a symposium on cancer immunology, taking place during 13-17 January. Associated with the symposia is a featured lecture, the Feodor Lynen Lecture, named in honor of the Department of Biochemistry's distinguished Visiting Professor. Past speakers were Drs. George Wald, Arthur Kornberg, Harland G. Wood, Earl W. Sutherland, Jr., and this year we heard from an old friend of the Department, Dr. Luis F. Leloir. These lectures are of an autobiographical nature, devoted to the life histories of these great scientists. They are greatly enjoyed by their audience, and for ourselves, remain a source of inspiration. The Lynen lecturer for 1975 will be Dr. Gerald M. Edelman. Our arrangement with the speakers and publishers is to ensure publica- tion as rapidly as possible. We thank the secretarial staff for their help in bringing this about. To bring forward as much of the recent work as possible, xiii PREFACE we now include a session of short communications in the meeting, the abstracts of which are included in this volume. We thank the speakers for submitting their manuscripts promptly and the participants whose interest and discussions provided the interactions that bring a symposium to life. The financial assistance of the University of Miami Departments of Anesthesiology and Medicine, the Howard Hughes Medical Institute, Derma- tology Foundation of Miami, Eli Lilly and Company, Hoffmann-La Roche Inc., MC/B Manufacturing Chemists and the International Union of Bio- chemistry, is gratefully acknowledged. The Union provided funds for the participation of Latin-American biochemists. This symposium volume also constitutes volume 62 of the IUB series. E. Y. C. Lee E. E. Smith XIV THE FIFTH FEODOR LYNEN LECTURE "I HATE TO BORE PEOPLE WITH MY RECOLLECTIONS" L.F. LELOIR Instituto de Investigaciones Bioquimicas "Fundacion Campomar", y Facultad de Ciencias Exactas y Naturales When Bill Whelan invited me to give the Lynen Lecture, which is of an autobiographical nature, I accept- ed with reluctance because I don't think that anything in my life is worth telling and much less, entertaining. Furthermore, I have already written an historical review called "Polysaccharide synthesis seen from Buenos Aires" (1) and it is difficult to write two biographies without having led a double life. My first difficulty with this lecture was that I could not find a title. I spent such a long time think- ing, that Whelan phoned me and it was then that I said "I hate boring people with my recollections". The long distance call was rather noisy and Whelan took that phrase as the title. Since I did not find a better one it was left as it is. My life covers the period of biochemistry in which most of the vitamins, hormones, enzymes and coenzymes were discovered and in which most of the reactions of intermediary metabolism were unravelled. I was born in 1906, the same year in which Harden and Young (2) pub- lished their paper on the coenzyme of yeast fermentation and which initiated the studies on cofactors in which we became involved many years later. After fairly normal studies in the primary and secondary school, I studied medicine, in Buenos Aires. I was an average student, interested in scientific subjects but had no occasion of thinking on research. This hap- pened while I was working in the hospital and I heard that Dr. Houssay was doing very interesting studies on carbohydrate metabolism. They were described to me as 1
The list of books you might like
