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Evidence-Based Complementary and Alternative Medicine Biological Values of Acupuncture and Chinese Herbal Medicine: Impact on the Life Science Guest Editors: Yong Qing Yang, Chen Yan, Chris J. Branford-White, and Xiang-Yu Hou Biological Values of Acupuncture and Chinese Herbal Medicine: Impact on the Life Science Evidence-Based Complementary and Alternative Medicine Biological Values of Acupuncture and Chinese Herbal Medicine: Impact on the Life Science Guest Editors: Yong Qing Yang, Chen Yan, Chris J. Branford-White, and Xiang-Yu Hou Copyright©2014HindawiPublishingCorporation.Allrightsreserved. Thisisaspecialissuepublishedin“Evidence-BasedComplementaryandAlternativeMedicine.”Allarticlesareopenaccessarticles distributedundertheCreativeCommonsAttributionLicense,whichpermitsunrestricteduse,distribution,andreproductioninany medium,providedtheoriginalworkisproperlycited. Editorial Board TerjeAlraek,Norway AnwarulH.Gilani,Pakistan AndreasMichalsen,Germany ShrikantAnant,USA MichaelGoldstein,USA DavidMischoulon,USA SedighehAsgary,Iran SveinHaavik,Norway Hyung-InMoon,RepublicofKorea HyunsuBae,RepublicofKorea Seung-HeonHong,Korea AlbertMoraska,USA LijunBai,China MarkusHorneber,Germany MarkMoss,UK SarangBani,India Ching-LiangHsieh,Taiwan MinKyunNa,RepublicofKorea VassyaBankova,Bulgaria BennyT.K.Huat,Singapore RichardL.Nahin,USA WinfriedBanzer,Germany RomanHuber,Germany VitalyNapadow,USA VernonA.Barnes,USA AngeloAntonioIzzo,Italy F.R.F.Nascimento,Brazil JairoK.Bastos,Brazil K.Jarukamjorn,Thailand IsabellaNeri,Italy SujitBasu,USA StefanieJoos,Germany T.B.Nguelefack,Cameroon DavidBaxter,NewZealand Z.Kain,USA MartinOffenbacher,Germany Andre-MichaelBeer,Germany OsamuKanauchi,Japan Ki-WanOh,RepublicofKorea AlvinJ.Beitz,USA KrishnaKaphle,Nepal Y.Ohta,Japan YongC.Boo,RepublicofKorea KenjiKawakita,Japan OlumayokunA.Olajide,UK FrancescaBorrelli,Italy JongY.Kim,RepublicofKorea ThomasOstermann,Germany GloriaBrusotti,Italy YounC.Kim,RepublicofKorea StaceyA.Page,Canada ArndtBu¨ssing,Germany C.-H.Kim,RepublicofKorea Tai-LongPan,Taiwan RaffaeleCapasso,Italy YoshiyukiKimura,Japan BhushanPatwardhan,India OpherCaspi,Israel ToshiakiKogure,Japan BeritS.Paulsen,Norway Shun-WanChan,HongKong ChingLan,Taiwan AndreaPieroni,Italy Il-MooChang,RepublicofKorea AlfredLa¨ngler,Germany RichardPietras,USA RajnishChaturvedi,India LixingLao,USA XianqinQu,Australia Tzeng-JiChen,Taiwan Jang-HernLee,RepublicofKorea CassandraL.Quave,USA YunfeiChen,China MyeongS.Lee,UK RojaRahimi,Iran KevinChen,USA TatleangLee,Singapore KhalidRahman,UK Juei-TangCheng,Taiwan ChristianLehmann,Canada CheppailRamachandran,USA EvanP.Cherniack,USA MarcoLeonti,Italy KeRen,USA Jen-HweyChiu,Taiwan Ping-ChungLeung,HongKong Mee-RaRhyu,RepublicofKorea WilliamC.S.Cho,HongKong ChunGuangLi,Australia Jose´LuisR´ıos,Spain JaeYoulCho,Korea Xiu-MinLi,USA PaoloR.diSarsina,Italy Shuang-EnChuang,Taiwan ShaoLi,China B.Saad,PalestinianAuthority EdwinL.Cooper,USA SabinaLim,Korea A.Sandner-Kiesling,Austria VincenzoDeFeo,Italy WenChuanLin,China AdairSantos,Brazil R.DelaP.Va´zquez,Spain ChristopherG.Lis,USA G.Schmeda-Hirschmann,Chile AlexandraDeters,Germany GerhardLitscher,Austria RosaSchnyer,USA MohamedEddouks,Morocco I-MinLiu,Taiwan AndrewScholey,Australia TobiasEsch,Germany KeLiu,China VeroniqueSeidel,UK YibinFeng,HongKong YijunLiu,USA SenthamilR.Selvan,USA J.Fernandez-Carnero,Spain GaofengLiu,China TuhinadriSen,India JulianoFerreira,Brazil GailB.Mahady,USA RonaldSherman,USA PeterFisher,UK SubhashC.Mandal,India KarenJ.Sherman,USA RomainForestier,France JeanineMarnewick,SouthAfrica KanShimpo,Japan JoelJ.Gagnier,Canada VirginiaS.Martino,Argentina Byung-CheulShin,Korea MuhammadN.Ghayur,Pakistan JamesH.McAuley,Australia RachidSoulimani,France MohdR.Sulaiman,Malaysia ManiVasudevan,Malaysia HarukiYamada,Japan VenilN.Sumantran,India CarloVentura,Italy NobuoYamaguchi,Japan TokuTakahashi,USA WagnerVilegas,Brazil Yong-QingYang,China RabihTalhouk,Lebanon PradeepVisen,Canada KenYasukawa,Japan CheChunTao,USA AristoVojdani,USA M.Yoon,RepublicofKorea MeiTian,China Chong-ZhiWang,USA HongQ.Zhang,HongKong YaoTong,HongKong Shu-MingWang,USA BoliZhang,China K.V.Trinh,Canada Y.Wang,USA RuixinZhang,USA VolkanTugcu,Turkey ChenchenWang,USA HongZhang,Sweden Yew-MinTzeng,Taiwan KenjiWatanabe,Japan HaiboZhu,China DawnM.Upchurch,USA W.Weidenhammer,Germany AlfredoVannacci,Italy J.M.Wilkinson,Australia Contents BiologicalValuesofAcupunctureandChineseHerbalMedicine:ImpactontheLifeScience, YongQingYang,ChenYan,ChrisJ.Branford-White,andXiang-YuHou Volume2014,ArticleID593921,2pages MicroarrayAnalysisofmRNAandMicroRNAExpressionProfileRevealstheRoleof 𝛽-Sitosterol-D-glucosideintheProliferationofNeuralStemCell,Li-huaJiang,Nian-yunYang, Xiao-linYuan,Yi-jieZou,Ze-qunJiang,Feng-mingZhao,Jian-pingChen,Ming-yanWang, andDa-xiangLu Volume2013,ArticleID360302,12pages ExploringPotentialChemicalTransformationbyChemicalProfilingApproachforRapidlyEvaluating ChemicalConsistencybetweenSun-DriedandSulfur-FumigatedRadixPaeoniaeAlbaUsing UltraperformanceLiquidChromatographyCoupledwithTime-of-FlightMassSpectrometry, JidaZhang,HaoCai,GangCao,XiaoLiu,ChengpingWen,andYongshengFan Volume2013,ArticleID763213,9pages ExtractsofTripterygiumwilfordiiHookFintheTreatmentofRheumatoidArthritis:ASystemicReview andMeta-AnalysisofRandomisedControlledTrials,YafeiLiu,ShenghaoTu,WeinaGao,YuWang, PeilinLiu,YonghongHu,andHuiDong Volume2013,ArticleID410793,11pages Electroacupuncture-InducedNeuroprotectionagainstCerebralIschemiainRats:RoleoftheDopamine D2Receptor,Ming-ShuXu,Shu-JingZhang,DanZhao,Cheng-YongLiu,Chang-ZhiLi,Chun-YanChen, Li-HuiLi,Ming-ZheLi,JiaXu,andLin-BaoGe Volume2013,ArticleID137631,10pages TheResearchofAcupunctureEffectiveBiomolecules:RetrospectandProspect,YuWang,Lei-MiaoYin, Yu-DongXu,Yan-YanLui,JunRan,andYong-QingYang Volume2013,ArticleID608026,6pages PostischemicLong-TermTreatmentwithQiangliTianmaDuzhongCapsuleImprovesBrainFunctional RecoveryviatheImprovementofHemorrheologyandtheInhibitionofPlateletAggregationinaRat ModelofFocalCerebralIschemia,Li-ZhiHong,Wei-weiGu,YongNi,MinXu,LeiYang,Yan-LiLiu, Shi-LingYang,QiangZhou,Xiu-MeiGao,andHui-LingZhang Volume2013,ArticleID795365,12pages TheEffectsofAcupunctureonBladderInterstitialCellsofCajalExcitabilityinRatswithOveractive Bladder,Qi-fanFeng,Yuen-haoHou,Wen-guangHou,Zhi-xianLin,Kang-minTang,andYue-laiChen Volume2013,ArticleID261217,10pages AcupunctureandMoxibustionforInflammatoryBowelDiseases:ASystematicReviewand Meta-AnalysisofRandomizedControlledTrials,JunJi,YuanLu,HuirongLiu,HuiFeng,FuqingZhang, LuyiWu,YunhuaCui,andHuanganWu Volume2013,ArticleID158352,11pages GeneExpressionProfilesatMoxibustionedSite(ST36):AMicroarrayAnalysis,Hai-YanYin,YongTang, Sheng-FengLu,LingLuo,Jia-PingWang,Xu-GuangLiu,andShu-GuangYu Volume2013,ArticleID890579,7pages EffectofElectroacupunctureInterventiononExpressionofCGRP,SP,COX-1,andPGE2ofDorsal PortionoftheCervicalSpinalCordinRatswithNeck-IncisionPain,Li-naQiao,Jun-yingWang, Yong-shengYang,Shu-pingChen,Yong-huiGao,Jian-liangZhang,andJun-lingLiu Volume2013,ArticleID294091,9pages RolesofChlorogenicAcidonRegulatingGlucoseandLipidsMetabolism:AReview,ShengxiMeng, JianmeiCao,QinFeng,JinghuaPeng,andYiyangHu Volume2013,ArticleID801457,11pages SpecificityofSensoryandMotorNeuronsAssociatedwithBL40andGB30intheRat:ADual FluorescentLabelingStudy,JingjingCui,LijuanHa,XinlongZhu,FuchunWang,XianghongJing, andWanzhuBai Volume2013,ArticleID643403,6pages SpecificLinkbetweenLungandLargeIntestine:ANewPerspectiveonNeuropeptideSecretioninLung withHerbalLaxativeStimulation,Xiang-GenZhong,Feng-JieZheng,Yu-HangLi,HongXu,QianWang, Yu-ChaoLiu,MiaoLiu,Ruo-HanWu,Yu-ShanGao,Shu-JingZhang,Jin-ChaoZhang,Tian-YuZhang, andSi-HuaGao Volume2013,ArticleID547837,9pages EffectsofAcupunctureon1-Chloro-2,4-dinitrochlorobenzene-InducedAtopicDermatitis,Ji-YeunPark, Hi-JoonPark,YouYeonChoi,MiHyeKim,Seung-NamKim,andWoongMoYang Volume2013,ArticleID982095,8pages MechanismsUnderlyingtheAntiproliferativeandProdifferentiativeEffectsofPsoralenonAdult NeuralStemCellsviaDNAMicroarray,YouNing,Jian-HuaHuang,Shi-JinXia,QinBian,YangChen, Xin-MinZhang,Jing-ChengDong,andZi-YinShen Volume2013,ArticleID452948,15pages BiofeedbackTherapyCombinedwithTraditionalChineseMedicinePrescriptionImprovesthe Symptoms,SurfaceMyoelectricity,andAnalCanalPressureofthePatientswithSpleenDeficiency Constipation,Yi-BoYao,Yong-QingCao,Xiu-TianGuo,JinYi,Hong-TaoLiang,ChenWang, andJin-GenLu Volume2013,ArticleID830714,7pages MoxibustionInhibitstheERKSignalingPathwayandIntestinalFibrosisinRatswithCrohn’sDisease, XiaomeiWang,YuanLu,LuyiWu,ChenZhao,ChunbinSong,ShuguangYu,BaixiaoZhao,TianpingZhao, HuirongLiu,ChuanziDou,YingyingZhang,andHuanganWu Volume2013,ArticleID198282,12pages AnInVivoandInVitroEvaluationoftheMutualInteractionsbetweentheLungandtheLarge Intestine,Lei-MiaoYin,Guang-QuanZhang,Xing-KeYan,YuWang,Yu-DongXu,andYong-QingYang Volume2013,ArticleID695641,9pages LowFrequencyElectroacupunctureAlleviatedSpinalNerveLigationInducedMechanicalAllodyniaby InhibitingTRPV1UpregulationinIpsilateralUndamagedDorsalRootGangliainRats, Yong-LiangJiang,Xiao-HuYin,Ya-FangShen,Xiao-FenHe,andJian-QiaoFang Volume2013,ArticleID170910,9pages InhibitoryEffectsofPC-SPESIIHerbalExtractonHumanBreastCancerMetastasis,Xiu-FengWang, JiaDu,Tian-LingZhang,Qian-MeiZhou,Yi-YuLu,HuiZhang,andShi-BingSu Volume2013,ArticleID894386,11pages TheEfficacyStudyonSiNiSanFreeze-DriedPowderonSleepPhaseinInsomniacandNormalRats, YuefengLi,AngguoLiu,YingWang,andXingkeYan Volume2013,ArticleID947075,6pages ElectroacupunctureInhibitionofHyperalgesiainRatswithAdjuvantArthritis:Involvementof CannabinoidReceptor1andDopamineReceptorSubtypesinStriatum,YinShou,YangYang, Ming-ShuXu,Ying-QianZhao,Lin-BaoGe,andBi-MengZhang Volume2013,ArticleID393460,10pages EvaluationoftheWoundHealingPotentialofResinaDraconis(Dracaenacochinchinensis)in AnimalModels,HuihuiLiu,ShaohuiLin,DanXiao,XiaoZheng,YanGu,andShanyuGuo Volume2013,ArticleID709865,10pages ChineseMedicineFormulaLingguizhuganDecoctionImprovesBeta-OxidationandMetabolismof FattyAcidinHigh-Fat-Diet-InducedRatModelofFattyLiverDisease,TaoLiu,Li-LiYang,LuZou, Dong-FeiLi,Hong-ZhuWen,Pei-YongZheng,Lian-JunXing,Hai-YanSong,Xu-DongTang,andGuangJi Volume2013,ArticleID429738,9pages AMeta-AnalysisofRandomizedControlledTrialsonAcupunctureforAmblyopia,XingkeYan, TiantianZhu,ChongbingMa,AnguoLiu,LiliDong,andJunyanWang Volume2013,ArticleID648054,6pages InvestigationoftheEffectofRiceWineontheMetabolitesoftheMainComponentsofHerbalMedicine inRatUrinebyUltrahigh-PerformanceLiquidChromatography-Quadrupole/Time-of-FlightMass Spectrometry:ACaseStudyonCornusofficinalis,GangCao,HaoCai,XiankeYue,SicongTu, BaochangCai,andZhiweiXu Volume2013,ArticleID306712,10pages Effectsof”BuShenHuoXueDecoction“ontheEndometrialMorphologyandExpressionofLeukaemia InhibitoryFactorintheRatUterusduringtheOestrousCycle,XinGong,YanyanYu,QingTong, YingRen,andZheJin Volume2013,ArticleID496036,9pages GanodermatsugaeExtractInhibitsGrowthofHER2-OverexpressingCancerCellsviaModulationof HER2/PI3K/AktSignalingPathway,Han-PengKuo,Shih-ChungHsu,Chien-ChihOu,Jhy-WeiLi, Hsiu-HsuehTseng,Tzu-ChaoChuang,Jah-YaoLiu,Shih-JungChen,Muh-HwanSu,Yung-ChiCheng, Wei-YuanChou,andMing-ChingKao Volume2013,ArticleID219472,12pages Editorial Biological Values of Acupuncture and Chinese Herbal Medicine: Impact on the Life Science Yong-QingYang,1ChenYan,2ChrisJ.Branford-White,3andXiang-YuHou4 1ShanghaiResearchInstituteofAcupunctureandMeridian,YueyangHospital,ShanghaiUniversityofTraditionalChineseMedicine, Shanghai201203,China 2CardiovascularResearchInstitute,UniversityofRochesterSchoolofMedicineandDentistry,Rochester,NY14642,USA 3InstituteforHealthResearchandPolicy,LondonMetropolitanUniversity,UK 4SchoolofPublicHealth,QueenslandUniversityofTechnology,VictoriaParkRoad,KelvinGrove,QLD4059,Australia CorrespondenceshouldbeaddressedtoYong-QingYang;[email protected] Received19November2013;Accepted19November2013;Published12January2014 Copyright©2014Yong-QingYangetal. This is an open access article distributed under the Creative Commons Attribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. As treasures of the traditional Chinese medicine (TCM), issuecollects24originalresearcharticlesand4reviewsthat acupuncture and Chinese herbal medicine have a history providetheclinicaloranimal-basedevidenceelucidatingthe of more than 2,500 years and have achieved sound effects impacts of acupuncture and Chinese herbal medicine on in the clinical practice [1]. The effects of acupuncture and the life science. Among these original research articles, the Chineseherbshaveusuallybeendemonstratedbybiological biological functionsand potential mechanisms of acupunc- regulationsofphysiologicalandpathologicalprocesses[2,3], ture and Chinese herbal drugs in disease treatment were whichareinherentresponsesofhumanbeingsandofgreat demonstrated in animal models of diseases such as focal importanceinthelifescienceresearch. cerebral ischemia, pain, atopic dermatitis, insomnia, fatty In recent years, the researches of acupuncture and Chi- liver, and Crohn’s disease. Two papers are on cancer cells: neseherbalmedicinehaveimprovedsignificantlyduetothe Han-PengKuoetal.reportedthatGanodermatsugaeextract prosperity and development of modern life science tech- inhibited the growth of HER2-overexpressing cancer cells nology [4–7]. At the same time, the studies of acupuncture andenhancedthegrowthinhibitoryeffectofantitumordrugs and Chinese herbal medicine have in turn enhanced the via the modulation of HER2/PI3K/Akt signaling pathway; development of biomedical science as well as the under- Xiu-FengWangetal.showedthatPC-SPESIIherbalextract standing of life [8–10] and offered new perspectives that could impair human breast cancer metastasis by regulat- can benefit modern medicine [11, 12]. However, the major ing proteolytic enzymes and matrix dynamics through the challengeoftheintegrationofTCMwithmodernmedicine p38MAPKandSAPK/JNKpathway.Additionally,YouNing istheinadequateunderstandingofthebiologicalfoundation et al. reported the molecular mechanisms underlying the of TCM experience and concepts. In order to deepen our antiproliferativeandprodifferentiativeeffectsofpsoralenon knowledge of TCM, it is important to clarify the biological adultneuralstemcellsusingDNAmicroarray.Interestingly, value and mechanistic action of acupuncture and Chinese two research articles (Lei-Miao Yin et al. and Xiang-Gen herbal medicine, which may turn hypothesis to solid data- Zhong et al.) simultaneously focused on the same issue, basedresearchandcreativediscoveryoflifescience. specificlinkbetweenthelungandthelargeintestine,which We are excited to present our readers with this special provide new lines of evidence for the modern biological issue that summarizes recent discoveries and knowledge of theoryof“exterior-interiorcorrelationbetweenZangandFu acupunctureand Chinese herbal medicine. This specialized

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Extracts of Tripterygium wilfordii Hook F in the Treatment of Rheumatoid Acupuncture and Moxibustion for Inflammatory Bowel Diseases: A Systematic Review and by use of SPSS version 16.0 software program for windows.
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