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Bioinformatics Computing - B. Bergeron (PTC, 2002) WW PDF

395 Pages·2002·5.21 MB·English
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• Table of Contents • Index Bioinformatics Computing By Bryan Bergeron Publisher: Prentice Hall PTR Pub Date: November 19, 2002 ISBN: 0-13-100825-0 Pages: 439 Slots: 1 In Bioinformatics Computing, Harvard Medical School and MIT faculty member Bryan Bergeron presents a comprehensive and practical guide to bioinformatics for life scientists at every level of training and practice. After an up-to-the-minute overview of the entire field, he illuminates every key bioinformatics technology, offering practical insights into the full range of bioinformatics applications- both new and emerging. Coverage includes: G Technologies that enable researchers to collaborate more effectively G Fundamental concepts, state-of-the-art tools, and "on the horizon" advances G Bioinformatics information infrastructure, including GENBANK and other Web-based resources G Very large biological databases: object-oriented database methods, data mining/warehousing, knowledge management, and more G 3D visualization: exploring the inner workings of complex biological structures G Advanced pattern matching techniques, including microarray research and gene prediction G Event-driven, time-driven, and hybrid simulation techniques Bioinformatics Computing combines practical insight for assessing bioinformatics technologies, practical guidance for using them effectively, and intelligent context for understanding their rapidly evolving roles. • Table of Contents • Index Bioinformatics Computing By Bryan Bergeron Publisher: Prentice Hall PTR Pub Date: November 19, 2002 ISBN: 0-13-100825-0 Pages: 439 Slots: 1 Copyright About Prentice Hall Professional Technical Reference Preface Organization of This Book How to Use This Book The Larger Context Acknowledgments Chapter 1. The Central Dogma The Killer Application Parallel Universes Watson's Definition Top-Down Versus Bottom-Up Information Flow Convergence Endnote Chapter 2. Databases Definitions Data Management Data Life Cycle Database Technology Interfaces Implementation Endnote Chapter 3. Networks Geographical Scope Communications Models Transmissions Technology Protocols Bandwidth Topology Hardware Contents Security Ownership Implementation Management On the Horizon Endnote Chapter 4. Search Engines The Search Process Search Engine Technology Searching and Information Theory Computational Methods Search Engines and Knowledge Management On the Horizon Endnote Chapter 5. Data Visualization Sequence Visualization Structure Visualization User Interface Animation Versus Simulation General-Purpose Technologies On the Horizon Endnote Chapter 6. Statistics Statistical Concepts Microarrays Imperfect Data Basics Quantifying Randomness Data Analysis Tool Selection Statistics of Alignment Clustering and Classification On the Horizon Endnote Chapter 7. Data Mining Methods Technology Overview Infrastructure Pattern Recognition and Discovery Machine Learning Text Mining Tools On the Horizon Endnote Chapter 8. Pattern Matching Fundamentals Dot Matrix Analysis Substitution Matrices Dynamic Programming Word Methods Bayesian Methods Multiple Sequence Alignment Tools On the Horizon Endnote Chapter 9. Modeling and Simulation Drug Discovery Fundamentals Protein Structure Systems Biology Tools On the Horizon Endnote Chapter 10. Collaboration Collaboration and Communications Standards Issues On the Horizon Endnote Bibliography Chapter One—The Central Dogma Chapter Two—Databases Chapter Three—Networks Chapter Four—Search Engines Chapter Five—Data Visualization Chapter Six—Statistics Chapter Seven—Data Mining Chapter Eight—Pattern Matching Chapter Nine—Modeling and Simulation Chapter Ten—Collaboration Index Copyright Library of Congress Cataloging-in-Publication Data A CIP catalogue record for this book can be obtained from the Library of Congress. Editorial/production supervision: Vanessa Moore Full-service production manager: Anne R. Garcia Cover design director: Jerry Votta Cover design: Talar Agasyan-Boorujy Manufacturing buyer: Alexis Heydt-Long Executive editor: Paul Petralia Technical editor: Ronald E. Reid, PhD, Professor and Chair, University of British Columbia Editorial assistant: Richard Winkler Marketing manager: Debby vanDijk © 2003 Pearson Education, Inc. Publishing as Prentice Hall Professional Technical Reference Upper Saddle River, New Jersey 07458 Prentice Hall books are widely used by corporations and government agencies for training, marketing, and resale. For information regarding corporate and government bulk discounts, please contact: Corporate and Government Sales Phone: 800-382-3419; E-mail:

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