Biodegradable Polymers in Clinical Use, Development - A. Domb, et. al., Wiley, 2011) WW

726 Pages·2011·14.44 MB·English

BIODEGRADABLE POLYMERS IN
CLINICAL USE AND CLINICAL
DEVELOPMENT

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BIODEGRADABLE
POLYMERS IN CLINICAL
USE AND CLINICAL
DEVELOPMENT

Edited by

Abraham J. Domb
Institute for Drug Design, Medicinal Chemistry
School of Pharmacy � Faculty of Medicine
The Hebrew University, Jerusalem, Israel

Neeraj Kumar
National Institute of Pharmaceutical Education and Research (NIPER),
S.A.S. Nagar, Punjab, India

Aviva Ezra
Institute for Drug Design, Medicinal Chemistry
School of Pharmacy � Faculty of Medicine
The Hebrew University, Jerusalem, Israel

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14 April 2011; 12:37:33

Copyright r 2011 by John Wiley & Sons, Inc. All rights reserved.

Published by John Wiley & Sons, Inc., Hoboken, New Jersey
Published simultaneously in Canada

No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any
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Library of Congress Cataloging-in-Publication Data:
Biodegradable Polymers in Clinical Use and Clinical Development / edited by Abraham J. Domb,
Neeraj Kumar, and Aviva Ezra.
p. cm
Includes index.
ISBN 978-0-470-42475-9 (hardback)
1. Polymers in medicine.
2. Biodegradable plastics.
I. Domb, A. J. (Abraham J.), editor of
compilation.
II. Jain, Jay Prakash.
Biodegradable polymers in drug delivery.
R857.P6B537
2011
610.28u4–dc22
2010043471

Printed in Singapore

oBook ISBN: 9781118015810
ePDF ISBN: 9781118015797
ePub ISBN: 9781118015803

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CONTENTS

CONTRIBUTORS
ix

PREFACE
xiii

PART I
GENERAL
1

1
Biodegradable Polymers in Drug Delivery
3
Jay Prakash Jain, Wubante Yenet, Abraham J. Domb, and Neeraj Kumar

PART II
BIODEGRADABLE POLYMERS OF NATURAL
ORIGIN: PROTEIN-BASED POLYMERS
59

2
Collagen
61
Wahid Khan, Deepak Yadav, Abraham J. Domb, and Neeraj Kumar

3
Properties and Hemostatic Application of Gelatin
91
Jalindar Totre, Diana Ickowicz, and Abraham J. Domb

PART III
BIODEGRADABLE POLYMERS OF NATURAL
ORIGIN: POLYSACCHARIDES
111

4
Chitosan and Its Derivatives in Clinical Use
and Applications
113
Anuradha Subramanian, Kirthanashri Srinivasan Vasanthan,
Uma Maheswari Krishnan, and Swaminathan Sethuraman

5
Clinical Uses of Alginate
137
Udi Nussinovitch and Amos Nussinovitch

v

TOC
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6
Dextran and Pentosan Sulfate — Clinical Applications
185
Ramu Parthasarathi and Athipettah Jayakrishnan

7
Arabinogalactan in Clinical Use
217
Rajendra P. Pawar, Babasaheb A. Kushekar, Bhaskar S. Jadhav,
Kiran R. Kharat, Ravikumar M. Borade, and Abraham J. Domb

PART IV
BIODEGRADABLE POLYMERS OF NATURAL
ORIGIN: POLYESTERS
247

8
Polyhydroxyalkanoate
249
Kesaven Bhubalan, Wing-Hin Lee, and Kumar Sudesh

PART V
SYNTHETIC BIODEGRADABLE POLYMERS
317

9
Lactide and Glycolide Polymers
319
Kevin Letchford, Anders So¨dergard, David Plackett,
Samuel Gilchrist, and Helen Burt

10
Polyanhydrides�Poly(CPP-SA), Fatty-Acid-Based
Polyanhydrides
367
Ravikumar M. Borade, Abraham J. Domb, Archana A. Sawale,
Rajendra P. Pawar, and Kiran R. Kharat

11
Poly(e-Caprolactone-co-Glycolide): Biomedical
Applications of a Unique Elastomer
401
Kevin Cooper, Aruna Nathan, and Murty Vyakarnam

12
Medicinal Applications of Cyanoacrylate
417
Rajendra P. Pawar, Ashok E. Jadhav, Sumangala B. Tathe,
Bhimrao C. Khade, and Abraham J. Domb

13
Polyethylene Glycol in Clinical Application and
PEGylated Drugs
451
Teerapol Srichana, and Tan Suwandecha

PART VI
INORGANIC POLYMERS
495

14
Calcium-Phosphate-Based Ceramics for
Biomedical Applications
497
Qing Lv, Kevin W.-H. Lo, Lakshmi S. Nair, and Cato T. Laurencin

vi
CONTENTS

TOC
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PART VII
BIODEGRADABLE POLYMERS FOR
EMERGING CLINICAL USES
519

15
Biocompatible Polymers for Nucleic Acid Delivery
521
Jeff Sparks, and Khursheed Anwer

16
Biodegradable Polymers for Emerging Clinical Use in
Tissue Engineering
565
Shalini Verma, Kalpna Garkhal, Anupama Mittal, and Neeraj Kumar

17
Injectable Polymers
631
Shimon A. Unterman, Norman A. Marcus, and Jennifer H. Elisseeff

PART VIII
IPR ASPECTS OF BIODEGRADABLE
POLYMERS
665

18
Global Patent and Technological Status of Biodegradable
Polymers in Drug Delivery and Tissue Engineering
667
Parikshit Bansal, Shalini Verma, Wahid Khan, and Neeraj Kumar

Index
727

CONTENTS
VII

TOC
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CONTRIBUTORS

KHURSHEED ANWER, EGEN, Inc., Huntsville, Alabama

PARIKSHIT BANSAL, Intellectual Property Right (IRR) Cell, Department of
Pharmaceutical Management, National Institute of Pharmaceutical
Education and Research (NIPER), Punjab, India

KESAVEN BHUBALAN, Department of Marine Science, Faculty of Maritime
Studies and Marine Science, Universiti Malaysia Terengganu, Terengganu,
Malaysia

RAVIKUMAR M. BORADE, Department of Chemistry, Government Arts and
Science College, Aurangabad, Maharashtra, India

HELEN BURT, Faculty of Pharmaceutical Sciences, University of British
Columbia, Vancouver, Canada

KEVIN COOPER, ARUNA NATHAN, MURTY VYAKARNAM, Advanced Technologies
and Regenerative Medicine, Somerville, NJ.

ABRAHAM J. DOMB, Institute for Drug Research, School of Pharmacy, Faculty
of Medicine, The Hebrew University, Jerusalem, Israel

JENNIFER H. ELISSEEFF, Department of Biomedical Engineering, Johns Hopkins
University, Baltimore, Maryland

KALPNA GARKHAL, Department of Pharmaceutics, National Institute of
Pharmaceutical Education and Research (NIPER), Punjab, India

SAMUEL GILCHRIST, Faculty of Pharmaceutical Sciences, University of British
Columbia, Vancouver, Canada

DIANA ICKOWICZ, Institute for Drug Research, School of Pharmacy, Faculty of
Medicine, The Hebrew University, Jerusalem, Israel

ASHOK E. JADHAV, Organic Chemistry Synthesis Laboratory, Dnyanopasak
College, Maharashtra, India

BHASKAR S. JADHAV, Department of Chemistry, Deogiri College, Maharashtra,
India

ix

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JAY PRAKASH JAIN, Department of Pharmaceutics, National Institute of
Pharmaceutical Education and Research (NIPER), Punjab, India

A. JAYAKRISHNAN, Department of Biotechnology, Indian Institute of
Technology, Chennai, India

BHIMRAO C. KHADE, Organic Chemistry Synthesis Laboratory, Dnyanopasak
College, Maharashtra, India

WAHID KHAN, Department of Pharmaceutics, National Institute of
Pharmaceutical Education and Research (NIPER), Punjab,
India

KIRAN R. KHARAT, Department of Biotechnology, Deogiri College,
Aurangabad, Maharashtra, India

UMA MAHESWARI KRISHNAN, Center of Nanotechnology & Advanced
Biomaterials, School of Chemical & Biotechnology, SASTRA University,
Tamil Nadu, India

NEERAJ KUMAR, Department of Pharmaceutics, National Institute of
Pharmaceutical Education and Research (NIPER), Punjab, India

BABASAHEB A. KUSHEKAR, Department of Chemistry, Deogiri College,
Maharashtra, India

CATO T. LAURENCIN, The University of Connecticut, Farmington, CT.

WING-HIN LEE, Ecobiomaterial Research Laboratory, School of Biological
Sciences, Universiti Sains Malaysia, Malaysia

KEVIN LETCHFORD, Faculty of Pharmaceutical Sciences, University of British
Columbia, Vancouver, Canada

KEVIN W.-H. LO, The University of Connecticut, Farmington, CT.

QING LV, The University of Connecticut, Farmington, CT.

NORMAN A. MARCUS, Department of Biomedical Engineering, Johns Hopkins
University, Baltimore, Maryland

ANUPAMA MITTAL, Department of Pharmaceutics, National Institute of
Pharmaceutical Education and Research (NIPER), Punjab, India

LAKSHMI NAIR, The University of Connecticut, Farmington, CT.

AMOS NUSSINOVITCH, Institute of Biochemistry, Food Science and Nutrition,
The Robert H. Smith Faculty of Agriculture, Food and Environment, The
Hebrew University of Jerusalem, Rehovot, Israel

UDI NUSSINOVITCH, Department of Medicine B, Chaim Sheba Medical Center,
Tel Hashomer, Israel

x
CONTRIBUTORS

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RAMU PARTHASARATHY, Department of Biotechnology, Indian Institute of
Technology, Chennai, India

RAJENDRA P. PAWAR, Department of Chemistry, Deogiri College, Aurangabad,
Maharashtra, India

DAVID PLACKETT, Risø National Laboratory for Sustainable Energy, Technical
University of Denmark, Roskilde, Denmark

ARCHANA A. SAWALE, Department of Chemistry, Viva College, Virar (W), Dist.
Thane, Maharashtra, India

SWAMINATHAN SETHURAMAN, Center of Nanotechnology & Advanced
Biomaterials, School of Chemical & Biotechnology, SASTRA University,
Tamil Nadu, India

ANDERS SO¨ DERGARD, Abo Akademi Univerisity, Laboratory of Polymer
Technology, Turku, Finland

JEFF SPARKS, EGEN, Inc., Huntsville, Alabama

TEERAPOL SRICHANA, Drug Delivery System Excellence Center, Faculty of
Pharmaceutical Sciences, Prince of Songkla University, Hatyai, Songkla,
Thailand

ANURADHA SUBRAMANIAN, Center of Nanotechnology & Advanced
Biomaterials, School of Chemical & Biotechnology, SASTRA University,
Tamil Nadu, India

KUMAR SUDESH, Ecobiomaterial Research Laboratory, School of Biological
Sciences, Universiti Sains Malaysia, Malaysia

TAN SUWANDECHA, Drug Delivery System Excellence Center, Faculty of
Pharmaceutical Sciences, Prince of Songkla University, Hatyai, Songkla,
Thailand

SUMANGALA B. TATHE, Organic Chemistry Synthesis Laboratory, Dnyanopasak
College, Maharashtra, India

JALINDER TOTRE, Institute for Drug Research, School of Pharmacy, The
Hebrew University, Jerusalem, Israel

SHIMON A. UNTERMAN, Department of Biomedical Engineering, Johns Hopkins
University, Baltimore, Maryland

KIRTHANASHRI SRINIVASAN VASANTHAN, Center of Nanotechnology & Advanced
Biomaterials, School of Chemical & Biotechnology, SASTRA University,
Tamil Nadu, India

SHALINI VERMA, Department of Pharmaceutics, National Institute of
Pharmaceutical Education and Research (NIPER), Punjab, India

CONTRIBUTORS
xi

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DEEPAK YADAV, Department of Pharmaceutics, National Institute of
Pharmaceutical Education and Research (NIPER), Punjab, India

WUBANTE YENET, Department of Pharmaceutics, National Institute of
Pharmaceutical Education and Research (NIPER), Punjab, India

xii
CONTRIBUTORS

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