ebook img

Biochemistry of Oxidative Stress: Physiopathology and Clinical Aspects PDF

448 Pages·2016·10.78 MB·English
Save to my drive
Quick download
Download
Most books are stored in the elastic cloud where traffic is expensive. For this reason, we have a limit on daily download.

Preview Biochemistry of Oxidative Stress: Physiopathology and Clinical Aspects

Advances in Biochemistry in Health and Disease Ricardo Jorge Gelpi Alberto Boveris Juan José Poderoso Editors Biochemistry of Oxidative Stress Physiopathology and Clinical Aspects Advances in Biochemistry in Health and Disease Series Editor: Naranjan S. Dhalla Winnipeg, Manitoba, Canada Volume 1: S. K. Cheema (ed), Biochemistry of Atherosclerosis Volume 2: S . W. Schaffer and M-Saadeh Suleiman (eds), Mitochondria: The Dynamic Organelle Volume 3: A . K. Srivastava and M. B. Anand-Srivastava (eds), Signal Transduction in the Cardiovascular System in Health and Disease Volume 4: B . Ostadal and N. S. Dhalla (eds), Cardiac Adaptations-Molecular Mechanisms Volume 5: B . I. Jugdutt and N. S. Dhalla (eds), Cardiac Remodeling-Molecular Mechanisms Volume 6: J awahar L. Mehta and N. S. Dhalla (eds), Biochemical Basis and Therapeutic Implications of Angiogenesis Volume 7: S . Chakraborti and N. S. Dhalla (eds), Proteases in Health and Disease Volume 8: S . Chakraborti and N. S. Dhalla (eds), Role of Proteases in Cellular Dysfunction Volume 9: B . Turan and N. S. Dhalla (eds), Diabetic Cardiomyopathy: Biochemical and Molecular Mechanisms Volume 10: P . S. Tappia and N. S. Dhalla (eds), Phospholipases in Health and Disease Volume 11: G . D. Lopaschuk and N. S. Dhalla (eds), Cardiac Energy Metabolism in Health and Disease Volume 12: K . Ahmed, O.-G. Issinger, and R. Szyszka (eds), Protein Kinase CK2 Cellular Function in Normal and Disease States Volume 13: I . M. C. Dixon and J. Wigle (eds), Cardiac Fibrosis and Heart Failure: Cause or Effect? Volume 14: S . Chakraborti and N. S. Dhalla (eds), Regulation of Ca2+-ATPases, V-ATPases and F-ATPases Volume 15: S . Chakraborti and N. S. Dhalla (eds), Regulation of Membrane Na+ -K + ATPase More information about this series at http://www.springer.com/series/7064 Ricardo Jorge Gelpi • Alberto Boveris Juan José Poderoso Editors Biochemistry of Oxidative Stress Physiopathology and Clinical Aspects Editors Ricardo Jorge Gelpi Alberto Boveris School of Medicine School of Pharmacy and Biochemistry University of Buenos Aires University of Buenos Aires Buenos Aires, Argentina Buenos Aires, Argentina Juan José Poderoso Instituto de Inmunología, Genética y Metabolismo (INIGEM, UBA– CONICET), Laboratorio de Metabolismo del Oxígeno, Hospital Universitario Universidad de Buenos Aires Buenos Aires, Argentina Advances in Biochemistry in Health and Disease ISBN 978-3-319-45864-9 ISBN 978-3-319-45865-6 (eBook) DOI 10.1007/978-3-319-45865-6 Library of Congress Control Number: 2016957889 © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland Preface This book was thought as a reference text for postgraduate courses and for its use in research laboratories that perform studies on the biochemistry and physiology of oxidative stress with its ongoing extension to physiopathology and clinical aspects, in this latter case considering a series of human diseases. Although the idea of oxi- dative stress has been linked to more than a hundred diseases, the book deals with its application to cardiovascular diseases, neurodegenerative and neurological dis- eases, metabolic syndrome, and cancer. Originally, in 1985, Helmut Sies in the book Oxidative Stress (H. Sies, ed., Academic Press, London, p. 1–8) coined the concept of oxidative stress as a situation of “unbalance with either an excessive production of oxidants or a decrease in antioxidants that lead to cellular damage.” The concept was a striking success and was immediately accepted and widely used both to design experimental studies and to explain obtained results. At the middle of 2016, after more than 30 years, the concept keeps its original strength and applicability. The entry “oxidative stress” in PubMed produces more than 160000 references. After the recognition of the deep changes that occur in the redox state of intracel- lular thiols in the oxidative stress situations, mainly due to the contributions of D.P. Jones (Am J Physiol Cell Physiol, 2008, 295, 849–868), the definition of oxida- tive stress incorporated the concept of the redox state of intracellular thiols (-SH) and disulfides (-SS-). The intracellular concentration of both reduced glutathione (GSH) and oxidized glutathione (GSSG) is about 2–5 mM, with 90–95 % in the reduced state; the ratio of reduced glutathione/glutathione disulfide (GSH/GSSG) is taken as a valid measurement of the whole intracellular redox sate. The current views about the general regulation of cellular metabolism are that a series of regula- tory proteins interact to keep cellular homeostasis and cell division. Most of these regulatory proteins have thiols and disulfides which are absolutely required for keeping the molecular conformation that is essential for their physiological regula- tory function and effects. Many of these proteins exert their regulatory function by redox reactions involving their -SH/-SS- groups. The current definition by Sies and Jones (Encyclopedia of Stress, 2007, Fink G., ed., vol. 3, Elsevier, Amsterdam, p. 45–48) is that “oxidative stress is a situation in which there is an imbalance between oxidants and antioxidants in favor of the oxidants, leading to a disruption v vi Preface of redox signaling and control.” This volume opens with the perspective chapter “The concept of oxidative stress after 30 years” by Helmut Sies. Many of the authors of the chapters in the present volume develop their scientific activities in South America. One of the aims of this book is its use as a reference text in post-graduate courses and research laboratories in Latin America countries. It is worth recalling that distinguished scientists from this geographical area, from Brazil, Peru, and Argentina, participated in the development of ideas and concepts that later were the thresholds and the tributaries of the concept of oxidative stress. Alvaro Ozório de Almeida started in Rio de Janeiro in 1934–1941 the research on the clinical uses of hyperbaric oxygen, at first in the treatment of gangrene and can- cer. Peruvian Eleazar Guzman Barron, working at the University of Chicago in the 1950s, established that glutathione and other similar thiols are highly sensitive to oxidation by ionizing radiation. Rebeca Gerschman, born in Argentina and disciple of Bernardo Houssay, working at the University of Rochester developed the “Gerschman theory” in 1954, in which she postulated that (a) the intermediates of the partial reduction of oxygen are the common molecular mechanism of oxygen and X-radiation toxicities, (b) an increase in oxygen partial pressure or a decrease in antioxidant defense leads equally to cell damage, and (c) aging is produced by the chronic effect of oxygen toxicity. The first two points are today fully accepted in the scientific community, with the second one reformulated in the form of Sies oxida- tive stress concept that is fully accepted and in evolution. The third point, oxygen toxicity and aging, is still in a sort of debate. However, an integration of the Gerschman theory and of the Harman theory (aging by free radical damage) is the preferred theory by the researchers in the field. This book on the “biochemistry of oxidative stress” was born in one of the visits of Prof. N.S. Dhalla to Buenos Aires at the beginning of 2014, in which he was invited to a coffee and associated chat that the three editors have every Saturday at La Biela, a coffee shop and a Buenos Aires landmark. Prof. Dhalla got curious about why these three people meet every week. The answer was that we have com- mon research interests and that frequently we publish scientific papers together. The existence of common research interests among these three full professors is some- how unexpected, because Ricardo Gelpi is professor of pathology and Juan J. (Teddy) Poderoso is professor of internal medicine, both of them at the School of Medicine of the University of Buenos Aires, and Alberto Boveris is professor of physical chemistry at the School of Pharmacy and Biochemistry of the same univer- sity. The present volume is one of the products of those coffees at La Biela in addi- tion to the mentioned joint publications. The coffee and chat meetings (and the similar drinks and chat meetings) are indeed a Spanish tradition called tertulia (no English word for that) that is a social gathering in which friends joint to discuss varied matters, usually in the salons of hotels and clubs. The book has four parts and 27 chapters keeping in mind the concept of oxidative stress and its application to human disease. Special comments will be made here for the chapters that deal with data from human patients. Part I is a general section devoted to oxidative stress and to the process of respiration, the basic cornerstone of mammalian biochemistry and cell physiology. This part opens with the chapter on Preface vii oxidative stress by H. Sies. Other chapters consider the evolution of aerobic life, the role of mitochondria as source of the species of the partial reduction of oxygen, the mitochondrial production of nitric oxide, and the general metabolism of nitric oxide and peroxynitrite in mammalian cell biochemistry and physiology. There is a chap- ter on the recently recognized intercellular mitochondrial transfer. The part closes with a chapter by Gonzales et al. on the adaptation of human life to high altitude, dealing with the Peruvian population living at the altitude in the Andes and compar- ing it with the other two stable high-altitude populations in Ethiopia and Tibet. Part II is devoted to cardiovascular diseases with emphasis in ischemia-reperfusion and in the corresponding cardiac protection provided by thioredoxin and by precondi- tioning. The thioredoxin protection in ischemia-reperfusion is analyzed in trans- genic mice in the chapter by D’Annunzio, Gelpi and colleagues. This part also has a chapter by Milei et al. with biochemical data on antioxidant supplementation in elderly cardiovascular hypertensive patients and on heart biopsy histological analy- sis in cardioplegic arrest/reperfusion in human cardiac surgery. Part III is devoted to neuronal function, neurodegeneration and neurodegenerative diseases, and their relationship to oxidative stress. A couple of most interesting chapters provide data involving patients, such as the one by Giulivi and colleagues, where autism in chil- dren is considered as a metabolic neurological disorder. Other chapter by Repetto and Boveris deals with the plasma markers of neurodegenerative diseases in human patients. Part IV contains chapters on metabolic syndrome and cancer. In this latter case, there is a chapter by J.J. Poderoso that considers cancer in the light of the Warburg theory of cancer as a mitochondrial phenomenon and that emphasizes in oxidative stress as the cause that leads to mutations and to cancer development. In another chapter, Merstelmann analyzes the recent success of immunotherapy in human cancer treatment. The editors of the scientific journal Science have chosen “cancer immunotherapy” as the Breakthrough of the Year in 2013 (Science 342:1432–1433, 2013). Buenos Aires, Argentina Ricardo Jorge Gelpi July 2016 Alberto Boveris Juan José Poderoso Contents Part I General Aspects 1 The Concept of Oxidative Stress After 30 Years . . . . . . . . . . . . . . . . . 3 Helmut Sies 2 The Evolution of the Earth and Its Atmosphere . . . . . . . . . . . . . . . . . 13 Juan José Poderoso 3 Mitochondria Are the Main Cellular Source of O−, HO 2 2 2 and Oxidative Stress . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23 Alberto Boveris and Marisa G. Repetto 4 Biochemistry and Physiology of Heart Mitochondrial Nitric Oxide Synthase . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 37 Tamara Zaobornyj, Darío E. Iglesias, Silvina S. Bombicino, Ivana A. Rukavina-Mikusic, and Laura B. Valdez 5 Biochemistry of Nitric Oxide and Peroxynitrite: Sources, Targets and Biological Implications . . . . . . . . . . . . . . . . . . . . 49 Adrián Aicardo, Débora M. Martinez, Nicolás Campolo, Silvina Bartesaghi, and Rafael Radi 6 Nitro-arachidonic Acid: Downstream Signaling and Therapeutics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 79 Homero Rubbo, Lucía González-Perilli, Mauricio Mastrogiovanni, Beatriz Sánchez-Calvo, and Andrés Trostchansky 7 Mitochondrial Transfer by Intercellular Nanotubes . . . . . . . . . . . . . . 95 Viviana Sanchez and Alicia Brusco 8 Human Adaptation to Life at High Altitude . . . . . . . . . . . . . . . . . . . . . 109 Gustavo F. Gonzales, Dulce E. Alarcón-Yaquetto, and Alisson Zevallos-Concha ix x Contents Part II Cardiovascular Diseases 9 Role of Oxidative Stress in Subcellular Defects in Ischemic Heart Disease . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 129 Monika Bartekova, Miroslav Barancik, and Naranjan S. Dhalla 10 Reduced Oxidative Stress as a Mechanism for Increased Longevity, Exercise and Heart Failure Protection with Adenylyl Cyclase Type 5 Inhibition . . . . . . . . . . . . . . 147 Stephen F. Vatner, Jie Zhang, and Dorothy E. Vatner 11 Regulation of Protein Nitrosylation by Thioredoxin 1 . . . . . . . . . . . . 163 Narayani Nagarajan and Junichi Sadoshima 12 Thioredoxin Attenuates Post-ischemic Damage in Ventricular and Mitochondrial Function . . . . . . . . . . . . . . . . . . . . . 177 Veronica D’Annunzio, Virginia Perez, Tamara Mazo, and Ricardo Jorge Gelpi 13 Antioxidant Supplementation in Cardiovascular Disease and Hypertension . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 193 José Milei, Susana Vila, Francisco Azzato, Giuseppe Ambrosio, and Matilde Otero-Losada 14 Oxidative Stress Influence in the Development of Pulmonary Arterial Hypertension . . . . . . . . . . . . . . . . . . . . . . . . . . 213 Adriane Belló-Klein, Alex Sander Araujo, Paulo Cavalheiro Schenkel, and Bruna Gazzi de Lima Seolin 15 Redox Regulation of Vascular Remodeling . . . . . . . . . . . . . . . . . . . . . 227 Leonardo Y. Tanaka, Denise de Castro Fernandes, and Francisco R. M. Laurindo 16 Mitochondrial Complex I Inactivation After Ischemia-Reperfusion in the Stunned Heart . . . . . . . . . . . . . . . . . . . . 245 Laura B. Valdez, Silvina S. Bombicino, Darío E. Iglesias, Ivana A. Rukavina- Mikusic, and Verónica D’Annunzio 17 Reactive Oxygen Species Are Involved in Myocardial Remote Ischemic Preconditioning . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 259 Martín Donato, Diamela T. Paez, Pablo Evelson, and Ricardo Jorge Gelpi 18 Inhaled Particulate Matter Leads to Myocardial Dysfunction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 275 Pablo Evelson, Timoteo Marchini, Mariana Garces, Lourdes Cáceres, Natalia Magnani, and Silvia Alvarez

Description:
The strongest point of this book titled “Biochemistry of Oxidative Stress: Physiopathology and Clinical Aspects”, is that the academic and scientific background of the authors/editors guarantee the authorship of a book comprising all aspects of oxidative stress, ranging from very molecular aspec
See more

The list of books you might like

Most books are stored in the elastic cloud where traffic is expensive. For this reason, we have a limit on daily download.