Biochemistry and Molecular Genetics of Cancer Metastasis: Proceedings of the Symposium on Biochemistry and Molecular Genetics of Cancer Metastasis Bethesda, Maryland — March 18–20, 1985

338 Pages·1986·11.94 MB·English

by  Ph.D. (auth.), Lance A. Liotta M.D., Dr. Karoly Lapis, Dr. Lance A. Liotta, Alan S. Rabson (eds.)

BIOCHEMISTRY AND MOLECULAR
GENETICS OF CANCER METASTASIS
DEVELOPMENTS IN ONCOLOGY
F.J. Cleton and J.W.I.M. Simons, eds.: Genetic Origins of Tumour Cells. 90-247-2272-l.
J. Aisner and P. Chang, eds.: Cancer Treatment and Research. 90-247-2358-2.
B.W. Ongerboer de Visser, D.A. Bosch and W.M.H. van Woerkom-Eykenboom, eds.: Neuro-
oncology: Clinical and Experimental Aspects. 90-247-2421-X.
K. Hellmann, P. Hilgard and S. Eccles, eds.: Metastasis: Clinical and Experimental Aspects.
90-247-2424-4.
H.F. Seigler, ed.: Clinical Management of Melanoma. 90-247-2584-4.
P. Correa and W. Haenszel, eds.: Epidemiology of Cancer of the Digestive Tract. 90-247-2601-8.
L.A. Liotta and I.R. Hart, eds.: Tumour Invasion and Metastasis. 90-247-2611-5.
J. Banoczy, ed.: Oral Leukoplakia. 90-247-2655-7.
C. Tijssen, M. Halprin and L. Endtz, eds.: Familial Brain Tumours. 90-247-2691-3.
F.M. Muggia, C.W. Young and S.K. Carter, eds.: Anthracycline Antibiotics in Cancer.
90-247-2711-1.
B.W. Hancock, ed.: Assessment of Tumour Response. 90-247-2712-X.
D.E. Peterson, ed.: Oral Complications of Cancer Chemotherapy. 0-89838-563-6.
R. Mastrangelo, D.G. Poplack and R. Riccardi, eds . : Central Nervous System Leukemia. Preven-
tion and Treatment. 0-89838-570-9.
A. Polliack, ed.: Human Leukemias. Cytochemical and Ultrastructural Techniques in Diagnosis
and Research. 0-89838-585-7.
W. Davis, C. Maitoni and S. Tanneberger, eds.: The Control of Tumor Growth and its Biological
Bases. 0-89838-603-9.
A.P.M. Heintz, C. Th. Griffiths and 1.B. Trimbos, eds.: Surgery in Gynecological Oncology.
0-89838-604-7.
M.P. Hacker, E.B. Double and I. Krakoff, eds.: Platinum Coordination Complexes in Cancer
Chemotherapy. 0-89838-619-5.
M.J. van Zwieten. The Rat as Animal Model in Breast Cancer Research: A Histopathological
Study of Radiation- and Hormone-Induced Rat Mammary Tumors. 0-89838-624-l.
B. Lowenberg and A. Hogenbeck, eds.: Minimal Residual Disease in Acute Leukemia.
0-89838-630-6.
I. van der Waal and G.B. Snow, eds.: Oral Oncology. 0-89838-631-4.
B.W. Hancock and A.M. Ward, eds.: Immunological Aspects of Cancer. 0-89838-664-0.
K.V. Honn and B.F. Sloane, eds.: Hemostatic Mechanisms and Metastasis. 0-89838-667-5.
K.R. Harrap, W. Davis and A.N. Calvert, eds.: Cancer Chemotherapy and Selective Drug
Development. 0-89838-673-X.
V.D. Velde, 1.H. Comelis and P.H. Sugarbaker, eds.: Liver Metastasis. 0-89838-648-5.
D.l. Ruiter, K. Welvaart and S. Ferrone, eds.: Cutaneous Melanoma and Precursor Lesions.
0-89838-689-6.
S.B. Howell, ed.: Intra-Arterial and Intracavitary Cancer Chemotherapy. 0-89838-691-8.
D.L. Kisner and J.F. Smyth, eds.: Interferon Alpha-2: Pre-Clinical and Clinical Evaluation.
0-89838-701-9.
P. Furmanski, J.C. Hager and M.A. Rich, eds.: RNA Tumor Viruses, Oncogenes, Human Cancer
and Aids: On the Frontiers of Understanding. 0-89838-703-5.
J.E. Talmadge, I.J. Fidler and R.K. Oldham: Screening for Biological Response Modifiers:
Methods and Rationale. 0-89838-712-4.
J.C. Bottino, R.W. Opfell and F.M. Muggia, eds.: Liver Cancer. 0-89838-713-2.
P.K. Pattengale, R.J. Lukes and C.R. Taylor, eds.: Lymphoproliferative Diseases: Pathogenesis,
Diagnosis, Therapy. 0-89838-725-6.
F. Cavalli, G. Bonadonna and M. Rozencweig, eds.: Malignant Lymphomas and Hodgkin's
Disease. 0-89838-727-2.
L. Baker, F. Valeriote and V. Ratanatharathom, eds.: Biology and Therapy of Acute Leukemia.
0-89838-728-0.
J. Russo, ed.: Immunocytochemistry in Tumor Diagnosis. 0-89838-737-X.
R.L. Ceriani, ed.: Monoclonal Antibodies and Breast Cancer. 0-89838-739-6.
D.E. Peterson, G.E. Elias and S.T. Sonis, eds.: Head and Neck Management of the Cancer
Patient. 0-89838-747-7.
D.M. Green: Diagnosis and management of Malignant Solid Tumors in Infants and Children.
0-89838-750-7.
K.A. Foon and A.C. Morgan, Jr., eds.: Monoclonal Antibody Therapy of Human Cancer.
0-89838-754-X.
J.O. McVie, et ai, eds., Clinical and Experimental Pathology of Lung Cancer. 0-89838-764-7.
K.V. Honn. W.E. Powers and B.F. Sloane, eds.: Mechanisms of Cancer Metastasis.
0-89838-765-5.
BIOCHEMISTRY AND MOLECULAR
GENETICS OF CANCER METASTASIS
Proceedings of the Symposium on Biochemistry
and Molecular Genetics of Cancer Metastasis
Bethesda, Maryland - March 18-20, 1985
edited by
Karoly Lapis
Semmelweis Medical University
Budapest, Hungary
Lance A. Liotta
National Institutes of Health
Bethesda, Maryland
Alan S. Rabson
National Institutes of Health
Bethesda, Maryland
Martinus Nijhoff Publishing
a member of the Kluwer Academic Publishers Group
Boston I Dordrecht I Lancaster
Distributors for North America:
Kluwer Academic Publishers
190 Old Derby Street
Hingham, Massachusetts 02043, USA
Distributors for the UK and Ireland:
Kluwer Academic Publishers
MTP Press Limited
Falcon House, Queen Square
Lancaster LAI IRN, UNITED KINGDOM
Distributors for all other countries:
Kluwer Academic Publishers Group
Distribution Centre
Post Office Box 322
3300 AH Dordrecht, THE NETHERLANDS
Library of Congress Cataloging-in-Publication Data
Symposium on Biochemistry and Molecular Genetics of
Cancer Metastasis (1985 : Bethesda, Md.)
Biochemistry and molecular genetics of cancer
metastasis.
(Developments in oncology)
Includes bibliographies and index.
1. Metastasis-Congresses. 2. Pathology, Molecular-
Congresses. 3. Cancer-Genetic aspects-Congresses.
4. Cancer-Immunological aspects-Congresses.
5. Molecular genetics-Congresses. I. Lapis, Karoly.
II. Liotta, L. A. (Lance A.) III. Rabson, Alan S.,
1926- IV. Title. V. Series. [DNLM: 1. Neoplasm
Metastasis-congresses. WI DE998N I QZ 202 S9795b 1985)
RC269.S39 1985 616.99 '407 85-30980
ISBN-13: 978-1-4612-9416-0 e-ISBN-13: 978-1-4613-2299-3
DOl: 10.1007/978-1-4613-2299-3
Copyright © 1986 by Martinus Nijhoff Publishing, Boston
Softcover reprint of the hardcover 1s t edition 1986
All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or
transmitted in any form or by any means, mechanical, photocopying, recording, or otherwise,
without written permission of the publisher, Martinus Nijhoff Publishing, 190 Old Derby Street,
Hingham, Massachusetts 02043.
CONTENTS
CONTRIBUTING AUTHORS viii
PREFACE xvii
Part One - Biochemistry and Molecular Biology Aspects
1. Biochemical and molecular biology approaches to study cancer 3
metastases
L. A. Liotta
2. Use of the chick embryo in studying the molecular genetics
11
of metastasis
A. F. Chambers
3. Integral membrane adhesion glycoproteins: What is their fate
25
during metastasis?
C. H. Damsky, K. A. Knudsen, A. F. Horwitz, M. J. Wheelock,
P. Gruber, and C. A. Buck
4. Peptide fragments of fibronectin and laminin: Role in cell
adhesion and inhibition of experimental tumor metastasis 43
L. Furcht, M. Basara, A. Norden-Skubitz, S. Palm, J. McCarthy,
and D. Sas
5. Role of ras oncogenes in experimental models of metastasis 55
U. P. Thorgeirsson, T. Turpeenniemi-Hujanen, M. E. Sobel,
J. E. Talmadge, and L. A. Liotta
6. Expression of p21ras gene products in fresh primary and meta-
static human tumor tissue 65
G. E. Gallick, R. Kurzrock, and J. U. Gutterman
7. A role for differentiation arrest in the development of
neural crest tumors 73
L. J. Helman, C. J. Thiele, W. M. Linehan, and M. A. Israel
8. Genetic and epigenetic regulation of the metastatic phenotype:
A basis for resolving the controversy regarding its selective
or random nature and variable phenotypic stability 83
R. S. Kerbel, P. Frost, and R. G. Liteplo
9. Cytochemical cell typing of metastatic tumors according to
their cytoskeletal proteins 101
R. Moll and W. W. Franke
10. Biochemistry and molecular biology RAWII? large cell lymphoma 115
G. L. Nicolson, V. Rotter, D. Wolf, T. Irimura, C. L. Reading,
M. Blick, R. La Biche, and M. Frazier
vi
11. Karyotypic progression and metastasis formation of human
tumors 129
P. C. Nowell and G. Balaban
12. Morphological and functional alterations of occ1udens, ad-
herens, and gap junctions in cancer 137
B. U. Pauli and R. S. Weinstein
13. Pattern of basement membrane degradation by metastatic
tumor cell enzymes 151
K. Tryggvason
Part Two - Immunologic Mechanisms
14. Gene products of the major histocompatibility complex control
the metastatic phenotype of tumor cells 167
L. Eisenbach, S. Katzav, G. HMrnrnerling, S. Segal, and M. Feldman
15. Generation of metastatic cells via somatic cell fusion: A
possible mechanism for tumor progression in-vivo 185
P. De Baetselier, E. Roos, L. Brys, L. Remel~nd M. Feldman
16. The recognition and destruction of metastatic cells by
tumoricidal macrophages 199
I. J. Fidler
17. Biological response modifiers for the therapy of metastases 213
R. B. Herberrnan, R. H. Wiltrout, R. R. Salup, J. R. Ortaldo,
and E. Gorelik
18. Differences in cell surface characteristics of poorly and
highly metastatic Lewis lung tumor variants 225
K. Lapis, J. Timar, F. Timar, K. Pal, and L. Kopper
19. Characteristics of LL2 and its lectin-resistant not metas-
tasizing variants 237
C. Radzikowski, D. Dus, A. Opolski, and L. Strzadala
20. A role for cell surface sialic acid in liberating meta-
static tumor cells from host control 251
V. Schirrmacher, J. Dennis, C. A. Waller, and P. Altevogt
Part Three - Clinical Perspectives and Applications
21. Tumor heterogeneity and empirical clinical cancer chemotherapy:
Current status and future prospects 265
S. K. Carter
22. Hormonal regulation of metastases: Prospects for pharmaco-
logical manipulation 279
R. G. Greig
23. Use of anti-tumor MABs for diagnosis and immunotherapy of
human tumors 293
H. Koprowski
24. New approaches to the adoptive immunotherapy of established
metastatic cancer using lyrnphokine-activated killer cells
and recombinant interleukin-2 307
S. A. Rosenberg and J. J. Mule
25. Preclinical screening of biological response modifiers:
Application to the treatment of metastatic disease 321
J. E. Talmadge
viii
CONTRIBUTING AUTHORS
Altevogt, Dr. P.
Institut fur Immunologie und Genetik
Deutsches Krebsforschungszentrum
D-6900 Heidelberg
Federal Republic of Germany
Balaban, Dr. G.
Department of Human Genetics
University of Pennsylvania School of Medicine
Philadelphia, PA 19104
Basara, Dr. M.
Department of Laboratory Medicine and Pathology
University of Minnesota
Minneapolis, MN 55455
Blick, Dr. M.
Department of Clinical Immunology and Biological Therapy
The University of Texas
M.D. Anderson Hospital and Tumor Institute
Houston, TX 77030
Brys, Dr. 1.
Instituut Voor Moleculaire Biologie
Vrije Universiteit Brusse1
B 1640 St.-Genesius-Rode
Paardenstraat 65
Brussels, Belgium
Buck, Dr. C. A.
The Wistar Institute
36th & Spruce Streets
Philadelphia, PA 19104
Carter, Dr. S. K.
Vice President, Anti-Cancer Research
Bristol-Myers Company
Pharmaceutical Research and Developmental Division
345 Park Avenue
New York, NY 10154
Chambers, Dr. A. F.
The London Regional Cancer Centre
and Department of Radiation Oncology
University of Western Ontario
London, Ontario, N6A 4GS, Canada
ix
Damsky, Dr. C. H.
Departments of Oral Biology and Anatomy
Schools of Dentistry and Medicine
HSW 681
University of California
San Francisco, CA 94341
De Baetselier, Dr. P.
Instituut Voor Moleculaire Biologie
Vrije Universiteit Brussel
B 1640 St.-Genesius-Rode
Paardenstraat 65
Brussels, Belgium
Dennis, Dr. J.
Department of Pathology
Richardson Laboratory
Queen's University
Kingston, Canada
Dus, Dr. D.
Department of Tumor Immunology
The Ludwik Hirszfeld Institute of Immunology
and Experimental Therapy
Polish Academy of Sciences
Wroclaw, Poland
Eisenbach, Dr. L.
Department of Cell Biology
The Weizmann Institute of Science
Rehovot, Israel
Feldman, Dr. M.
Department of Cell Biology
The Weizmann Institute of Science
Rehovot, Israel
Fidler, Dr. Isaiah J.
Department of Cell Biology
University of Texas
M.D. Anderson Hospital and Tumor Institute
6723 Bertner Avenue
Houston, TX 77030
Franke, Dr. W. W.
Institute of Cell and Tumor Biology
German Cancer Research Center
D-6900 Heidelberg
Federal Republic of Germany
Frazier, Dr. M.
Department of Medicine
Baylor College of Medicine
Houston, TX 77030
x
Frost, Dr. P.
Department of Cell Biology
University of Texas System Cancer Center
M.D. Anderson Hospital and Tumor Institute
Houston, TX 77030
Furcht, Dr. L. T.
Stone Professor of Pathology
Department of Laboratory Medicine and Pathology
University of Minnesota Medical School
Box 609 Mayo Memorial Building
420 Delaware Street S.E.
Minneapolis, MN 55455-0315
Gallick, Dr. G.
Department of Tumor Biology
University of Texas
M.D. Anderson Hospital and Tumor Institute
6723 Bertner Avenue
Houston, TX 77030
Gorelik, Dr. E.
Biological Therapeutics Branch
Biological Response Modifiers Program
Division of Cancer Treatment
National Cancer Institute
Frederick, MD 21701
Greig, Dr. R.
Assistant Director
Department of Tumor Biology L-I09
Smith Kline & French Laboratories
1500 Spring Garden Street
P.O. Box 7929
Philadelphia, PA 19101
Gruber, Dr. P.
The Wistar Institute
36th & Spruce Streets
Philadelphia, PA 19104
Gutterman, Dr. J. U.
Clinical Immunology
M.D. Anderson Hospital and Tumor Institute
Houston, TX 77030
HHmmerling, Dr. G.
Institute for Immunology and Genetics
German Cancer Research Center
D-6900 Heidelberg
Federal Republic of Germany