Biochemical Pharmacology 2003: Vol 65 Table of Contents

15 Pages·2003·2.9 MB·English

ELSEVIER
Biochemical Pharmacology 65 (2003) 2101-2114
www.elsevier.com/locate/biochempharm
Contents of Volume 65
1 January 2003 89 The antioxidant activity of caroverine
Natalia Udilova, Andrey V. Kozlov,
Werner Bieberschulte, Klemens Frei,
Commentary
Klaus Ehrenberger and Hans Nohl
Small molecule antagonists of proteins
Thomas R. Gadek and John B. Nicholas Antioxidant and pro-oxidant properties of pyrrolo-
quinoline quinone (PQQ): implications for its func-
Rapid Communication tion in biological systems
U50,488 inhibits HIV-1 Tat-induced monocyte
Kai He, Hitoshi Nukada, Teiji Urakami and
chemoattractant protein-! (CCL2) production by
Michael P. Murphy
human astrocytes
Wen S. Sheng, Shuxian Hu, James R. Lokensgard and Reversal of P-glycoprotein-mediated multidrug resis-
tance by ginsenoside Rg;
Phillip K. Peterson
Seung-Whan Kim, Hyog-young Kwon,
Dong-Whan Chi, Jai-Heon Shim, Jong-Dae Park,
MOLECULAR AND CELLULAR PHARMACOLOGY You-Hui Lee, Suhkneung Pyo and Dong-Kwon Rhee
Altered lymphocyte catecholamine reactivity in mice Inhibition of acetylcholine-mediated effects by
subjected to chronic mild stress borneol
Valeria Ayelli Edgar, Dafne Magali Silberman, Tae-Ju Park, Yong-Soo Park, Tae-Gyun Lee,
Graciela A. Cremaschi, Luis M. Zieher and Hyunjung Ha and Kyong-Tai Kim
Ana Maria Genaro
Modulation by caspases of tumor necrosis factor-
Plasma stability of two glycosyl indolocarbazole anti- stimulated c-Jun N-terminal kinase activation but
tumor agents not nuclear factor-KB signaling
Jean-Francois Goossens, Jéréme Kluza, Hervé Vezin, Alison F. Littlejohn, Steven J. Tucker,
Mustapha Kouach, Gilbert Briand, Brigitte Baldeyrou, Ahmed A.A. Mohamed, Stephen McKay,
Nicole Wattez and Christian Bailly Matt J. Helms, Peter Vandenabeele and
David J. MacEwan
Potent inhibitory effect of naturally occurring flavo-
noids quercetin and kaempferol on in vitro osteoclas- Evaluation of oxidative stress during apoptosis and
tic bone resorption necrosis caused by b-galactosamine in rat liver
Alice Wattel, Said Kamel, Romuald Mentavervi, Fang Sun, Eri Hamagawa, Chihiro Tsutsui,
Florence Lorget, Christophe Prouillet, Jean-Pierre Petit, Naomi Sakaguchi, Yuri Kakuta, Sadako Tokumaru and
Patrice Fardelonne and Michel Brazier Shosuke Kojo
Reactive oxygen species are involved in the stimula-
tion of the mitochondrial permeability transition by CCHEMOTHERAPY AND METABOLIC INHIBITORS
dihydrolipoate
Preclinical factors influencing the relative contribu-
Sarune Morkunaite-Haimi, Alexey G. Kruglov, tions of Phase I and II enzymes to the metabolism of
Vera V. Teplova, Klaus Stolze, Lars Gille, the experimental anti-cancer drug 5,6-dimethyl-
Hans Nohl and Nils-Erik L. Saris xanthenone-4-acetic acid
Sodium tanshinone IIA sulfonate mediates electron Shufeng Zhou, Philip Kestell, Bruce C. Baguley
transfer reaction in rat heart mitochondria and James W. Paxton
Guangyin Zhou, Wen Jiang, Yan Zhao, Guangén Ma, 121 Influence of p53 and p21 WAFI expression on sensitivity
Wenjuan Xin, Junjie Yin and Baolu Zhao of cancer cells to cladribine
doi: 10.1016/S0006-2952(03)00323-X
Contents of Volume 65
Carlos Maria Galmarini, Nathalie Voorzanger, José Manuel Garcia-Martinez, Juan Angel Fresno Vara,
Nicole Falette, Lars Jordheim, Emeline Cros, Pedro Lastres, Carmelo Bernabéu, Pablo Ortiz Betés and
Alain Puisieux and Charles Dumontet Jorge Martin-Perez
The effects of cladribine and fludarabine on DNA
NEUROSCIENCI methylation in K562 cells
Dorota Wyczechowska and
Neuronal death signaling by B-bungarotoxin through
Krystyna Fabianowska-Majewska
the activation of the N-methyl-b-aspartate (NMDA)
receptor and L-type calcium channel . ; ree
The involvement of diadenosine 5’,5/”-P',P*-tetra-
Wen-Pei Tseng and Shoei-Yn Lin-Shiau phosphate in cell cycle arrest and regulation of apop-
COSIS
PHARMACOLOGY Amalia A. Vartanian, H. Suzuki and Andrey I. Poletaes
Pharmacology of vanilloids at recombinant and endo- 237 Down-regulation of deoxycytidine kinase in human
genous rat vanilloid receptors leukemic cell lines resistant to cladribine and clofar-
Vera Ralevic, Jeffrey C. Jerman, abine and increased ribonucleotide reductase activity
Stephen J. Brough, John B. Davis, contributes to fludarabine resistance
Julie Egerton and Darren Smart Emma Mansson, Emma Flordal, Jan Liliemark,
Tatiana Spasokoukotskaja, Howard Elford,
Svetlana Lagercrantz, Staffan Eriksson and
15 January 2003 Freidoun Albertioni
Development of insulin resistance and reversal by
thiazolidinediones in C2C12 skeletal muscle cells
Commentary
Naresh Kumar and Chinmoy S. Dey
Advances in the pathophysiology of constitutive and
inducible cyclooxygenases: two enzymes in the spot- Effects of glycolipids from spinach on mammalian
light DNA polymerases
Luca Parente and Mauro Perretti Chikako Murakami, Taeko Kumagai, Takahiko Hada,
Ui Kanekazu, Satoshi Nakazawa, Shinji Kamisuki,
Naoki Maeda, Xianai Xu, Hiromi Yoshida,
Fumio Sugawara, Kengo Sakaguchi and
Yoshiyuki Mizushina
Pyridoxal isonicotinoy! hydrazone analogs induce
apoptosis in hematopoietic cells due to their iron- Vitamin E activates gene expression via the pregnane
chelating properties X receptor
Joan L. Buss, Jiri Neuzil, Nina Gellert, Nico Landes, Paul Pfluger, Dirk Kluth, Marc Birringer,
Christian Weber and Prem Ponka Ralph Riihl, Gaby-Fleur Bél, Hansruedi Glatt and
Regina Brigelius-Flohé
Oversulfation of fucoidan enhances its anti-angio-
genic and antitumor activities
Satoru Koyanagi, Noboru Tanigawa, Hiroo Nakagawa, (CHEMOTHERAPY AND METABOLIC INHIBITORS
Shinji Soeda and Hiroshi Shimeno
DNA repair mechanisms involved in gemcitabine
Human mitochondrial and cytosolic branched-chain cytotoxicity and in the interaction between gemcita-
aminotransferases are cysteine S-conjugate B-lyases, bine and cisplatin
but turnover leads to inactivation Mirjam Crul, Robert C.A.M. van Waardenburg,
Arthur J.L. Cooper, Sam A. Bruschi, Myra Conway and Suzanne Bocxe, Maria A.J. van Eijndhoven,
Susan M. Hutson Dick Pluim, Jos H. Beijnen and Jan H.M. Schellens
Yessotoxin, a novel phycotoxin, activates phospho-
diesterase activity. Effect of yessotoxin on cAMP HorMONES AND GROWTH FACTORS
levels in human lymphocytes
Cooperative enhancement of insulinotropic action of
Amparo Alfonso, Laura de la Rosa, Mercedes R. Vieytes, GLP-1 by acetylcholine uncovers paradoxical inhibi-
Takeshi Yasumoto and Luis M. Botana tory effect of beta cell muscarinic receptor activation
Effect of metamizol on promyelocytic and terminally on adenylate cyclase activity
differentiated granulocytic cells. Comparative Jodo C. Miguel, Yasser H.A. Abdel-Wahab,
analysis with acetylsalicylic acid and diclofenac Brian D. Green, Paulo C.F. Mathias and Peter R. Flatt
Contents of Volume 65
Effects of high glucose on cytokine-induced nerve Joan L. Buss, Emmanuele Arduini,
growth factor (NGF) expression in rat renal mesan- Kyle C. Shephard and Prem Ponka
gial cells
Relevance of mitogen activated protein kinase
Klaus Heese, Karl-Friedrich Beck,
(MAPK) and _p hosphotidylinositol-3-kinase/protein
Meik Helmut Behrens, Katharina Pliss,
kinase B (PI3K/PKB) pathways to induction of apop-
Wolfgang Fierlbeck, Andrea Huwiler, Heiko Miihl,
tosis by curcumin in breast cells
Helmut Geiger, Uwe Otten and Josef Pfeilschifter
Matthew S. Squires, E. Ann Hudson, Lynne Howells,
Stewart Sale, Catherine E. Houghton, J. Louise Jones,
INFLAMMATION AND IMMUNOPHARMACOLOGY Louise H. Fox, Martin Dickens, Sally A. Prigent and
Margaret M. Manson
Inhibition of cytokine production by the herbicide
atrazine. Search for nuclear receptor targets Effects of rhein on human articular chondrocytes in
Sabrina Devos, Karolien De Bosscher, alginate beads
Bart Staels, Ellinor Bauer, Frank Roels, Christelle Sanchez, Marianne Mathy-Hartert,
WimVanden Berghe, Guy Haegeman, Michelle A. Deberg, Herve Ficheux,
Robert Hooghe and Elisabeth L. Hooghe-Peters Jean-Yves L. Reginster and Yves E. Henrotin
The Cl/-HCO; exchanger slows the recovery of
1 February 2003 acute pH, changes in rat mast cells
Natalia Vilariio, Laura A. de la Rosa,
Mercedes R. Vieytes and Luis M. Botana
Commentary Endothelium-dependent and -independent relaxa-
Anthrax toxin receptor proteins tion and VASP serines 157/239 phosphorylation by
cyclic nucleotide-elevating vasodilators in rat aorta
Kenneth A. Bradley and John A.T. Young
Andreas Schafer, Mick Burkhardt, Tobias Vollkommer,
Johann Bauersachs, Thomas Miinzel, Ulrich Walter and
Rapid Communication
Albert Smolenski
Potent inhibition of human _ folylpolyglutamate
synthetase by a phosphinic acid mimic of the tetra- B-Amyloid aggregation induced by human acetylcho-
hedral reaction intermediate linesterase: inhibition studies
John J. McGuire, William H. Haile, Nadya Valiaeva, Manuela Bartolini, Carlo Bertucci, Vanni Cavrini and
David Bartley, Jianxia Guo and James K. Coward Vincenza Andrisano
Glucosidation of hyodeoxycholic acid by UDP-
MOLECULAR AND CELLULAR PHARMACOLOGY glucuronosyltransferase 2B7
Peter Mackenzie, Joanna M. Little and
Bullatacin, a potent antitumor Annonaceous aceto-
Anna Radominska-Pandya
genin, induces apoptosis through a reduction of intra-
cellular cAMP and cGMP levels in human hepatoma
(CHEMOTHERAPY AND METABOLIC [INHIBITORS
2.2.15 cells
Hui-Fen Chiu, Tsai-Tung Chih, Yun-Mei Hsian, Apoptosis and TRAF-1 cleavage in Epstein-Barr
Chih-Hua Tseng, Ming-Jung Wu and Yang-Chang Wu virus-positive nasopharyngeal carcinoma cells treated
with doxorubicin combined with a farnesyl-transfer-
Dihydropyridines as inhibitors of capacitative cal-
ase inhibitor
cium entry in leukemic HL-60 cells
Jean-Michel Vicat, Hector Ardila-Osorio,
Jacquie L. Harper, Carol §. Camerini-Otero, An-Hu Li,
Abdelmajid Khabir, Marie-Christine Brezak,
Soon-Ai Kim, Kenneth A. Jacobson and John W. Daly Isabelle Viossat, Philip Kasprzyk, Rachid Jlidi,
Cholesteryl-hemisuccinate-induced apoptosis of pro- Paule Opolon, Tadamassa Ooka, Grégoire Prevost,
myelocytic leukemia HL-60 cells through a cyclos- Dolly P. Huang and Pierre Busson
porin A-insensitive mechanism
NEUROSCIENCE
Katsuhiko Yamada, Kayo Arita, Hirotsugu Kobuchi,
Shinji Yamamoto, Tamotsu Yoshioka, Hiroshi Tamai and Affinity of cyamemazine, an anxiolytic antipsychotic
Kozo Utsumi drug, for human recombinant dopamine vs. serotonin
receptor subtypes
Lipophilicity of analogs of pyridoxal isonicotinoy]
hydrazone (PIH) determines the efflux of iron com- Ahcéne Hameg, Franck Bayle, Philippe Nuss,
plexes and toxicity in K562 cells Philippe Dupuis, Ricardo P. Garay and Michel Dib
Contents of Volume 65
GENE EXPRESS 915 Interactions of peroxynitrite and other nitrating sub-
stances with human platelets: the role of glutathione
441 Effect of genotype on steady-state CYPIAI gene
and peroxynitrite permeability
expression in human peripheral lymphocytes
Maria Lufrano and Michael Balazy
Seymour Garte, Sabya Ganguly and Emanuela Taioli
Differential allosteric modulation by amiloride analo-
S 4 gues of agonist and antagonist binding at A, and A;
adenosine receptors
Probing the binding of the flavonoid, quercetin to
human serum albumin by circular dichroism, electro- Zhan-Guo Gao, Neli Melman, Andreas Erdmann,
nic absorption spectroscopy and molecular modelling Seong Gon Kim, Christa E. Miiller,
methods Adriaan P. IJzerman and Kenneth A. Jacobson
Ferenc Zsila, Zsolt Bikdadi and Miklos Simonyi Impaired receptor-mediated endocytosis by the asia-
loglycoprotein receptor in ethanol-fed mice: implica-
INFLAMMATION AND IMMUNOPI
tions for studying the role of this receptor in alcoholic
Suppression of tumor necrosis factor-% and inducible apoptosis
nitric oxide synthase gene expression by THI 52, a Shana R. Dalton, Robert L. Wiegert, Cheryl R. Baldwin,
new synthetic naphthyl-benzylisoquinoline alkaloid Karen M. Kassel and Carol A. Casey
Young J. Kang, Bog K. Lee, Young S. Lee, Han G. Seo,
Uroporphyrin accumulation in hepatoma cells
Min K. Park, Hyo J. Kim, Hyang S. Pyo,
expressing human or mouse CYPIA2: relation to
Won S. Chong, Hye J. Jung, Hye S. Yun-Choi,
the role of CYP1A2 in human porphyria cutanea
Duck H. Lee and Ki C. Chang
tarda
Dimethylsphingosine increases cytosolic calcium and
Ralph C. Nichols, Sandra Cooper, Heidi W. Trask,
intracellular pH in human T lymphocytes
Nadia Gorman, Timothy P. Dalton, Daniel W. Nebert,
A. Alfonso, L.A. De la Rosa, M.R. Vieytes Jacqueline F. Sinclair and Peter R. Sinclair
and | M Botana
The voltage- and time-dependent blocking effect of
trifluoperazine on T lymphocyte Kv1.3 channels
G > I h I IN Nl RENA PH
Andrzej Teisseyre and Krystyna Michalak
479 Metabolism of quercetin-7- and quercetin-3-glucuro-
nides by an in vitro hepatic model: the role of human
Selective activation of deoxycytidine kinase by thy-
B-glucuronidase, sulfotransferase, catechol-O- midine-5’-thiosulphate and release by deoxycytidine
methyltransferase and multi-resistant protein 2 in human lymphocytes
(MRP2) in flavonoid metabolism
Gergely Keszler, Karoly Szikla, Zygmunt Kazimierczuk,
Karen A. O’Leary, Andrea J. Day, Paul W. Needs, Tatjana Spasokoukotskaja, Maria Sasvari-Szekely and
Fred A. Mellon, Nora M. O'Brien and Gary Williamson Maria Staub
Activation of deoxycytidine kinase by UV-C-irradia-
15 February 2003 tion in chronic lymphocytic leukemia B-lymphocytes
Eric Van Den Neste, Caroline Smal, Sabine Cardoen,
Anne Delacauw, Joélle Frankard, Augustin Ferrant,
Commentary Georges Van den Berghe and Francoise Bontemps
Use of the A , adenosine receptor as a physiological
Effect of arvanil (N-arachidonoyl-vanillyl-amine), a
immunosuppressor and to engineer inflammation m
nonpungent anandamide—capsaicin hybrid, on ion
VIVO
currents in NG108-15 neuronal cells
Michail V Sitkousky
Yuk-Keung Lo, Hung-Ting Chiang and Sheng-Nan Wu
Mo_Le R AND CELLULAR PHARMA\ (
Diminished production of nitric oxide synthase cofac-
Apoptosis induction by the dual-action DNA- and tor tetrahydrobiopterin by rosiglitazone in adipocytes
protein-reactive antitumor drug irofulven is largely Philippe Linscheid, Ulrich Keller, Nenad Blau,
Bcl-2-independent Dominik J. Schaer and Beat Miiller
Maryanne C.S. Herzig, Alex V. Trevino,
Huiyun Liang, Richard Salinas, Stephen J. Waters, Inhibition of ATP-sensitive K -channels by a sulfo-
nylurea analogue with a phosphate group
John R. MacDonald, Barbara A. Woynarowska and
Jan M. Woynarowski Katja Hastedt and Uwe Panten
Contents of Volume6 5
CHEMOTHERAPY AND METABOLIC INHIBITORS Timothy W. Noblitt, John M. Richardson,
Ho Yeong Song and John E. Hale
Structure activity analysis of the pro-apoptotic, anti-
tumor effect of nitrostyrene adducts and related com-
pounds CA‘ RD.¥ IOVASCULA. R — AND — PULMONARY> P5 HARMACOLO- GY
Sylvia Kaap, Iris Quentin, Dereje Tamiru, Delphinidin inhibits endothelial cell proliferation
Mohammed Shaheen, Kurt Eger and and cell cycle progression through a_ transient
Hans Jiirgen Steinfelder
activation of ERK-1/-2
Sophie Martin, Laure Favot, Rachel Matz,
NEUROSCIENC! Claire Lugnier and Ramaroson Andriantsitohaina
Antioxidants significantly affect the formation of dif-
ferent classes of isoprostanes and neuroprostanes in GASTROINTESTINAL AND RENAL PHARMACOLOGY
rat cerebral synaptosomes
Osthole prevents anti-Fas antibody-induced hepatitis
Thomas J. Montine, Kathleen S$. Montine,
in mice by affecting the caspase-3-mediated apoptotic
Erin E. Reich, Erin S. Terry, Ned A. Porter and
pathway
Jason D. Morrow
Toshihiro Okamoto, Toru Kawasaki and Okio Hino
Modulation of ["H] TBOB binding to the rodent
GABA 4 receptor by simple disaccharides Indomethacin-induced free radical-mediated changes
in the intestinal brush border membranes
N. Rezai, C. Duggan, D. Cairns, G. Lees and
P.L. Chazot Jayasree Basivireddy, Molly Jacob,
Prabhu Ramamoorthy, Anna B. Pulimood and
Effects of zinc ion on type A monoamine oxidase in
Kunissery A. Balasubramanian
monkey brain mitochondria
Toru Egashira, Fusako Takayama and Kumiko Sakai
Corrigendum
Corrigendum to “The involvement of L-y-glutamyl-L-
HORMONES AND GROWTI cysteinyl-glycine (glutathione/GSH) in the mechan-
Insulin and estrogen receptor ligand influence the ism of redox signaling mediating MAPK! *®_depen-
FGF-2 activities in MCF-7 breast cancer cells dent regulation of pro-inflammatory cytokine
production”. [Biochem. Pharma. 63 (2002) 305-320]
Martine Garnier, Claire Giamarchi, Isabelle Delrieu,
Marie-Christine Rio, Patrick Chinestra, Francis Bayard, iTh n i Haddad
Marc Poirot and Jean-Charles Faye
1 March 2003
GENE EXPRESSION AND DEVELOPMENT
Ethanol consumption decreases the synthesis of the
mannose 6-phosphate/insulin-like growth factor II
Commentary
receptor but does not decrease its messenger RNA
“Multivalent” saccharides: development of new
James Haorah, Richard G. MacDonald, Julie A. Stoner approaches for inhibiting the effects of glycosphingo-
and Terrence M. Donohue Jr lipid-binding pathogens
Cara-Lynne Schengrund
ND IMMUNOPHARMACOL(
Suppression of human monocyte interleukin-1B
MOLECULAR AND CELLULAR PHARMACOLOGY
production by ajulemic acid, a nonpsychoactive
cannabinoid Daidzein enhances osteoblast growth that may be
mediated by increased bone morphogenetic protein
Robert B. Zurier, Ronald G. Rossetti,
(BMP) production
Sumner H. Burstein and Bonnie Bidinger
Tie-Liu Jia, Hong-Zhong Wang, Li-Ping Xie,
Decoy receptor 3 (DcR3) is proteolytically processed
Xue-Yan Wang and Rong-Qing Zhang
to a metabolic fragment having differential activities
against Fas ligand and LIGHT Transcriptional suppression of the adrenal cortical
peripheral-type benzodiazepine receptor gene and
Victor J. Wroblewski, Derrick R. Witcher,
Gerald W. Becker, Kelly A. Davis, Shenshen Dou, inhibition of steroid synthesis by ginkgolide B
Radmila Micanovic, Christy M. Newton, Hakima Amri, Katy Drieu and Vassilios Papadopoulos
Contents of Volume 65
Melatonin differentially modulates the expression (CHEMOTHERAPY AND METABOLIC INHIBITOI
and function of the hMT, and hMT melatonin
Cellular transformation of the investigational new
receptors upon prolonged withdrawal
anticancer drug NB1011, a phosphoramidate of 5-
Monica I. Masana, Paula A. Witt-Enderby and
(2-bromovinyl)-2’-deoxyuridine, results in modifica-
Margarita L Dubocovich tion of cellular proteins not DNA
Protein glutathiolation in human blood Maria V. Sergeeva and Brian E. Cathers
Wayne A. Kleinman, Despina Komninou,
An oxidative mechanism of interferon induced prim-
Yvonne Leutzinger, Stephen Colosimo, Julie Cox,
ing of the Fas pathway in Fanconi anemia cells
Calvin A. Lang and John P. Richie Jr.
Michal Pearl-Yafe, Drora Halperin, Ayelet Halevy,
Minimally modified phosphodiester antisense oligo-
Henry Kalir, Bella Bielorai and Ina Fabian
deoxyribonucleotide directed against the multidrug
resistance gene mdr]
NEUROSCIENCE
Imane Brigui, Taraneh Djavanbc ‘h t Samani
Béatrice Jolleés, Sophie Pigaglio and Alain Laigle
Statin effects on cholesterol micro-domains in brain
Apoptotic cell death induction by F 11782 a novel plasma membranes
dual catalytic inhibitor of topoisomerases | and II Christopher Kirsch, Gunter P. Eckert and
( hantal Etiévan Anna Kruczynski , Jean-Marc Barret, Walter E. Mueller
Dominique Perrina s Bridget T. Hill
The role of multidrug resistance proteins MRP1, DEVELOPMENT
MRP2 and MRP3 in cellular folate homeostasis
Toxicogenomics of bromobenzene hepatotoxicity: a
1 Hendrik Hooijberg, Godefridus J. Peters,
combined transcriptomics and proteomics approach
ios G. Assaraf, letie Kathmann, David G. Priest,
Wilbert H.M. Heijne, Rob H. Stierum, Monique Slijper,
Marlene A. Bunni, Anjo J.P. Veerman,
Peter J. van Bladeren and Ben van Ommen
George L Scheffer, Gertjan J.L. Kaspers and
Gerrit Jansen
Inhibition of 15-lipoxygenases by flavonoids: struc- ND IMMUNOPHARMA(
ture—activity relations and mode of action
Flavonoids inhibit myelin phagocytosis by macro-
Christian David Sadik, Helmut Sies and Tankred Schewe phages; a structure—activity relationship study
ET, receptor-mediated Ca~~ mobilisation in H9c2 Jerome J. A. Hendriks, Helga E. de Vries,
C urdi IC cells Susanne M.A . van der Pol, Timo K. van den Berg,
Francesca Ceccarelli, Maria C. Scavuzzo, Laura Giusti Eric A. F van Tol and Christine D. Dijkstra
Gianni Bigini, Barbara Costa, Vittoria Carnicelli, Inhibition of the NF-«B signaling pathway mediates
Riccardo Zucchi, Antonio ppie and the anti-inflammatory effects of petrosaspongiolide M
Maria R. Mazzoni
Inmaculada Posadas, Maria Carmen Terencio,
Differential effects of YM440 a hypoglycemic agent Antonio Randazzo, Luigi Gomez-Paloma,
on binding to a peroxisome proliferator-activated Miguel Paya and Maria José Alcaraz
receptor Y} and its transactivation
The effect of sesquiterpene lactones on the release of
Eiji Kurosaki, Ryosuke Nakano, Akiyoshi Shimaya,
human neutrophil elastase
Shigeru Yoshida, Motoko Ida, Takayuki Suzuki,
Bettina Siedl e, Linda Gustavsson, Senia Johansson,
Masayuki Shibasaki and Hisataka Shikama
Renato Murillo, Victor Castro, Lars Bohlin and
Involvement of nitric oxide/cyclic GMP signaling Irmgard Merfort
pathway in the regulation of fatty acid metabolism
Heme oxygenase-! induction and regulation in unsti-
in rat hepatocytes
mulated mouse peritoneal macrophages
Javier Garcia-Villafranca, Alberto Guillén and
Ana Maria Vicente, Maria Isabel Guillén and
Je se ( ‘astro
Maria José Alcaraz
Characterization of the molecular interactions of
interleukin-8 (CXCLS8), erowth related oncogen %
— 1) and a non-peptide antagonist (SB L\M ONAR4 Y > PHARKAMAA COLO1 GY
o11
25002) with the human CXCR2
Calpain inhibitor (BSF 409425) diminishes ischemia/
Julie Catusse, Anne Liotard, Bruno Loillier, reperfusion-induced damage of rabbit heart mito-
Didier Pruneau and Jean-Luc Paquet chondria
Contents of Volume 65 2107
Sonata Trumbeckaite, Christane Neuhof, 995 Expression profiles of three isoforms of inositol 1,4,5-
Stephan Zierz and Frank N. Gellerich trisphosphate receptor in brown adipose tissue of the
rat
Kazuaki Kajimoto, Takiko Daikoku, Naoshi Yamazaki,
15 March 2003 Hiroshi Terada and Yasuo Shinohara
Commentary
CHEMOTHERAPY AND METABOLIC INHIBITORS
Corticotropin-releasing hormone (CRH) and immu-
notolerance of the fetus Trypanosoma cruzi: effect and mode of action of
nitroimidazole and nitrofuran derivatives
Antonis Makrigiannakis, Emmanuel Zoumakis,
Sofia Kalantaridou, Nikos Mitsiades, Andreas Margioris , Juan Diego Maya, Soledad Bollo,
George P. Chrousos and Achilleas Gravanis Luis J. Nuriez-Vergara, Juan A. Squella,
Yolanda Repetto, Antonio Morello, Jacques Périé and
Gérard Chauviere
AR PHARMACOLOGY
Tumor necrosis factor 4-induced apoptosis in astro-
INFLAMMATION AND IMMUNOPHARMAC(
cytes is prevented by the activation of P2Y,, but not
P2Y, nucleotide receptors The inhibition of mast cell activation by neutrophil
Seong G. Kim, Kelly A. Soltysiak, Zhan-Guo Gao, lactoferrin: uptake by mast cells and interaction with
Tong-Shin Chang, Eunju Chung and tryptase, chymase and cathepsin G
Kenneth A. Jacobson Shaoheng He, Alan R. McEuen, Sally A. Blewett,
Ping Li, Mark G. Buckley, Paul Leufkens and
Assessment of sarcoplasmic reticulum Ca~*-uptake
Andrew F. Walls
during the development of left ventricular hyper-
trophy
Ramesh C. Gupta, Xiao-Ping Yang, Sudhish Mishra and CARDIOVASCULAR AND PULMONARY PHARMACOLOGY
Hani N. Sabbah Down-regulation of bradykinin B»-receptor mRNA
p23 enhances the formation of the aryl hydrocarbon in the heart in pressure-overload cardiac hypertrophy
receptor-DNA complex in the rat
Premnath V. Shetty, Bhagyashree Y. Bhagwat and Katsutoshi Yayama, Satoshi Matsuoka,
Makoto Nagaoka, Eri Shimazu, Masaoki Takano and
William K. Chan
Hiroshi Okamoto
Opposing mechanisms of NADPH-cytochrome P450
oxidoreductase regulation by peroxisome proliferators
1 April 2003
Li-Qun Fan, Jackie Coley, Richard T. Miller,
Russell C. Cattley and J. Christopher Corton
Peptide G protein agonists from a phage display Commentaries
library Broad-spectrum chemokine inhibitors (BSClIs) and
Jutta Hessling, Martin J. Lohse and Karl-Norbert Klotz their anti-inflammatory effects in vivo
David J. Grainger and Jill Reckless
Kinetic analysis of fluorescein and dihydrofluorescein
effluxes in tumour cells expressing the multidrug MultidiscipIl inary utilization of dimethyl sulfoxide:
resistance protein, MRP] pharmacological, cellular, and molecular aspects
Chantarawan Saengkhae, Chatchanok Loetchutinat and Nuno C. Santos, J. Figueira-Coelho,
Arlette Garnier-Suillerot J. Martins-Silva and Carlota Saldanha
Regulation of cyclooxygenase-2 expression by ilo-
prost in human vascular smooth muscle cells. Role MOLECULAR AND CELLULAR PHARMACOLOGY)
of transcription factors CREB and ICER
Investigation of the cellular mechanism of inhibition
Svenja Debey, Jutta Meyer-Kirchrath and Karsten Schrér
of formyl-methionyl-leucyl-phenylalanine-induced
Expression of acetoacetyl-CoA synthetase, a novel superoxide anion generation in rat neutrophils by 2-
cytosolic ketone body-utilizing enzyme, in human benzyloxybenzaldehyde
brain Jih-Pyang Wang, Ling-Chu Chang, Yi-Lee Lin,
Masahiro Ohgami, Noriko Takahashi, Mei-Feng Hsu, Chiung-Yun Chang, Li-Jiau Huang and
Masahiro Yamasaki and Tetsuya Fukui Sheng-Chu Kuo
2108 Contents of Volume 65
1053 Resveratrol-induced G> arrest through the inhibition CHEMOTHERAPY AND ABOLIC INHIBITORS
of CD. K7r ~ and p34°"C"D~ kinases in colon carcinoma
Decreased expression of the reduced folate carrier
HT29 cells
and folypolyglutamate synthetase is the basis for
Yu-Chih Liang, Shu-Huei Tsai, Linda Chen, acquired resistance to the pemetrexed antifolate
Shoei-Yn Lin-Shiau and Jen-Kun Lin
(LY231514) in an L1210 murine leukemia cell
Cytotoxicity and apoptosis of benzoquinones: redox line
cycling, cytochrome c release, and BAD protein Yanhua Wang, Rongboa Zhao and I. David Goldman
expression
Gabriela Tudor, Peter Gutierrez, ) IMMUNOPHARMACOI
Angelica Aguilera-Gutierrez and Edward A. Sausville
Polycationic peptides as inhibitors of mast cell serine
Effects of D3.49A, R3.50A, and A6.34E mutationso n proteases
ligand binding and activation of the cannabinoid-2 Anders Lundequist, Maria Aparecida Juliano,
(CB2) receptor Luiz Juliano and Gunnar Pejler
Wenke Feng and Z.H. Song
OG)
Interaction of upstream stimulatory factor proteins
with an E-box located within the human CYP1A2
5’-flanking gene contributes to basal transcriptional heart cells: a comparison between cardiac myocytes
gene activation and nonmyocytes
George V. Pickwell, Hsueh Shih and Kyoko Takahashi, Mistuhiro Azuma, Tomoko Yamada,
Linda C. Quattrochi Yuko Ohyabu, Koichi Takahashi, Stephen W. Schaffer
and Junichi Azuma
Thyroxine-derivatives of lipopeptides: bifunctional
dimerization inhibitors of human immunodeficiency Effects of angiotensin II on vascular endothelial cells:
virus-1 protease formation of receptor-mediated reactive nitrogen
species
Julien Dumond, Nicole Boggetto, Hans J. Schramm
Wolfgang Schramm, Masayuki Takahashi and Michael J. Mihm, Suvara K. Wattanapitayakul,
Ss
Michele Reboud-Ravaux Sheng-Fu Piao, Dale G. Hoyt and John Anthony Bauer
Pharmacological characterisation of a cell line GASTROINTESTINAL AND RENAI
expressing GABA g);, and GABA, receptor subunits
Absorption of quercetin-3-glucoside and quercetin-
Warren D. Hirst, Adam J. Babbs, Andrew Green,
4’-glucoside in the rat small intestine: the role of
Jayne A.L. Minton, Tracy E. Shaw, Alan Wise,
lactase phlorizin hydrolase and the sodium-depen-
Simon Q. Rice, Menelas N. Pangalos and
dent glucose transporter
Gary W. Price
Andrea J. Day, Jennifer M. Gee, M. Susan DuPont,
Concentration dependent mitochondrial effect of
lan T. Johnson and Gary Williamson
amiodarone
Gabor Varbiro, Ambrus Toth, Antal Tapodi, 15 April 2003
Balazs Veres, Balazs Sumegi and Ferenc Gallyas Jr
Activation of p53 by the cytoprotective aminothiol Commentary
WR1065: DNA-damage-independent pathway and Receptor-mediated adrenocorticoid hormone signal-
redox-dependent modulation of p53 DNA-binding ing in ocular tissues
activity
Massoud Mirshahi and Manjul K. Agarwal
Olivier Pluquet, Sophie North,
Marie-Jeanne Richard and Pierre Hainaut
MOLECULAR AND CELLULAR PHARMACOLOGY
Interaction of the D2,,... dopamine receptor with G
Iron and transition metal transport into erythrocytes
proteins: analysis of receptor/G protein selectivity
mediated by nifedipine degradation products and
Sarah A. Nickolls and Philip G. Strange related compounds
Regulation of mastoparan-induced increase of para- Donna L. Savigni, Dieter Wege, Garth S. Cliff,
cellular permeability in T84 cells by RhoA and baso- Mark L.H. Meesters and Evan H. Morgan
lateral potassium channels
1227 Comparison of the pharmacological antagonism of
Irina Blumenstein, Ralf Gerhard, Jtirgen Ries, M, and M; muscarinic receptors expressed in isola-
Gabor Kottra and Jtirgen Stein tion and in combination
Contents of Volume 65 2109
Michael T. Griffin, Jake Ching-Hsuan Hsu, Marta Szaszak, Laszlo Hunyady, Veerle Kersemans and
Darakhshanda Shehnaz and Frederick J. Ehlert Georges Vauquelin
Inhibition of the MEK/ERK pathway has no effect on A two-state model of antagonist-AT, receptor inter-
agonist-induced aggregation of human platelets action: further support by binding studies at low
Archibald McNicol and Elke C.G. Jackson temperature
Ilse Verheijen, Jean-Paul De Backer,
Cloning and characterisation of the first drug-meta-
Patrick Vanderheyden and
bolising canine UDP-glucuronosyltransferase of the
Georges Vauquelin
2B subfamily
Matthew G. Soars, Michelle Fettes,
Audrey C. O'Sullivan, Robert J. Riley,
CHEMOTHERAPY AND METABOLIC INHIBITORS
Brian T. Ethell and Brian Burchell
Antitumor effect of the cinnamaldehyde derivative
Oxathiolene oxides: a novel family of compounds
CB403 through the arrest of cell cycle progression
that induce ferritin, glutathione S-transferase, and
in the G/M phase
other proteins of the phase II response
Ha-Won Jeong, Dong Cho Han,
E. Christine Pietsch, Allison L. Hurley,
Kwang-Hee Son, Mi Young Han,
Elizabeth E. Scott, Benjamin P. Duckworth,
Mark E. Welker, Sandra Leone-Kabler, Jong-Seok Lim, Ji-Hong Ha,
Chang Woo Lee, Hwan Mook Kim,
Alan J. Townsend, Frank M. Torti and
Hyoung-Chin Kim and Byoung-Mog Kwon
Suzy V. Torti
Two-step formation of -H NMR visible mobile lipids Cellular uptake of a catechol iron chelator and
during apoptosis of paclitaxel-treated K562 cells chloroquine into Plasmodium falciparum infected
erythrocytes
Fabrizia Brisdelli, Egidio lorio, Arno Knijn,
Amalia Ferretti, Donatella Marcheggiani, Luisa Lenti, Akli Hammadi, Florence Ramiandrasoa,
Roberto Strom, Franca Podo and Argante Bozzi Veronique Sinou, Christophe Rogier, Thierry Fusai,
Jacques Le Bras, Daniel Parzy, Gerhard Kunesch
Cellular bases of the antitumor activity of a 7-substi- and Bruno Pradines
tuted camptothecin in hormone-refractory human
prostate carcinoma models
INFLAMMATION AND IMMUNOPHARMACOLOG)
Valentina Zuco, Rosanna Supino,
Michelandrea De Cesare, Nives Carenini, Paola Perego,
In vitro effects of mangiferin on superoxide concen-
Laura Gatti, Graziella Pratesi, Claudio Pisano, trations and expression of the inducible nitric oxide
Roberta Martinelli, Federica Bucci, Romina Zanier, synthase, tumour necrosis factor-% and transforming
Paolo Carminati and Franco Zunino
growth factor-fB genes
Inhibition of pancreatic stellate cell activation by the José Manuel Leiro, Ezequiel Alvarez,
hydroxymethylglutaryl coenzyme A reductase inhibi- Juan Alberto Arranz, Isabel Gonzalez Siso and
tor lovastatin Francisco Orallo
Robert Jaster, Peter Brock, Gisela Sparmann,
Decrease of the inflammatory response and induction
Jérg Emmrich and Stefan Liebe of the Akt/protein kinase B pathway by poly-(ADP-
Recognition of DNA modified by antitumor cisplatin ribose) polymerase | inhibitor in endotoxin-induced
by “latent” and “active” protein p53 septic shock
Miroslav Fojta, Hana Pivonkova, Marie Brazdova, Balazs Veres, Ferenc Gallyas Jr., Gabor Varbiro,
Lucie Kovarova, Emil Palecek, Sarka Pospisilova, Zoltan Berente, Erzsebet Osz, Gyorgy Szekeres,
Borivoj Vojtesek, Jana Kasparkova and Viktor Brabec Csaba Szabo and Balazs Sumegi
Activation of the coactivator four-and-a-half-LIM-
only protein FHL2 and the c-fos promoter through CARDIOVASCULAR AND PULMONARY PHARMACOLOGY
inhibition of protein phosphatase 2A
A novel antioxidant, octyl caffeate, suppression of
Mona Johannessen, Petter Angell Olsen,
LPS/IFN-y-induced inducible nitric oxide synthase
Bjarne Johansen, Ole Morten Seternes and Ugo Moens gene expression in rat aortic smooth muscle cells
Peptide and nonpeptide antagonist interaction with George Hsiao, Ming-Yi Shen, Wen-Chiung Chang,
constitutively active human AT, receptors Yu-Wen Cheng, Shiow-Lin Pan, Yueh-Hsiung Kuo,
Minh Tam Le, Patrick M.L. Vanderheyden, Tzeng-Fu Chen and Joen-Rong Sheu
Contents of Volume 65
1 May 2003 1483 Beneficial effects of L-carnitine in myoblastic C2C12
cells. Interaction with zidovudine
Béatrice Georges, Stéphane Galland, Caroline Rigault,
Francoise Le Borgne and Jean Demarquoy
Commentary
1393 Modulatory effects of hormones, drugs, and toxic Evaluation of B-adrenergic receptor subtypes in the
events on renal Organic anion transport human prostate cancer cell line-LNCaP
Sylvie A. Terlouw, Rosalinde Masereeuw and Rangaswamy Nagmani, David S. Pasco,
Frans G.M. Russel Ruben D. Salas and Dennis R. Feller
MOLECULAR AND CELL PHARMAC GROWTH FACTORS
1407 | Jiscovery and characterization of a potent and selec- Effect of in vivo administered hexachlorobenzene
tive non-amidine inhibitor of human factor Xa on epidermal growth factor receptor levels, protein
Amy M. Liang, David R. Light, Monica Kochanny, tyrosine kinase activity, and phosphotyrosine content
Galina Rumennik, Lan Trinh, Dao Lentz, Joseph Post, in rat liver
John Morser and Michael Snider Andrea§ . Randi, Horacio A. Sancovich,
Ana M. Ferramola de Sancovich,
Multidrug resistance correlates with overexpression
of Muc4 but inversely with P-glycoprotein and multi- Andrea Loaiza, Rodolfo A. Kolliker Frers,
Fernanda Spinelli and Diana L. Kleiman de Pisare1
drug resistance related protein in transfected human
melanoma cells
Role of nerve growth factor in the regulation of
Yan-Ping Hu, Bushra Hag, Kermit L. Carraway, parotid cell differentiation induced by rat serum
Niramol Savaraj and Theodore J. Lampidis
Takashi Takeuchi, John M. Aletta,
Further studies on the interaction of nonpolyglutama- Suzanne G. Laychock, Yingrao Tian
table aminopterin analogs with dihydrofolate reduc- and Ronald P. Rubin
tase and the reduced folate carrier as determinants of
Established theory of radiation-induced decay is not
in vitro antitumor activity
generalizable to Bolton—Hunter labeled peptides
Joel E. Wright, Gregory K. Yurasek, Ying-Nan Chen and Amanda C. Doran, Yieh-Ping Wan,
Andre Ri SOU sky Alan S. Kopin and Martin Beinborn
Molecular mechanisms for the activation of Ca*~-
permeable nonselective cation channels by endothe- GENE EXPRESSION AND DEVELOPMENT
lin-1 in C6 glioma cells
Frequent co-occurrence of the TATA box mutation
Yoshifumi Kawanabe, Nobuo Hashimoto and
associated with Gilbert’s syndrome (UGT1A1*28)
Tomoh Masaki with other polymorphisms of the UDP-glucuronosyl-
The effect of valproic acid on drug and steroid glu- transferase-1 locus (UGT1A6*2 and UGT1A7*3) in
curonidation by expressed human UDP-glucuronosyl- Caucasians and Egyptians
transferases Christoph Kéhle, Bernd Mohrle, Peter A. Miinzel,
Brian T. Ethell, Gail D. Anderson and Brian Burchell Matthias Schwab, Dorothee Wernet,
Osama A. Badary and Karl Walter Bock
Induction of apoptosis in estrogen dependent and
independent breast cancer cells by the marine terpe
noid dehydrothyrsiferol
Martina K. Pec, Amable Aguirre, Karin Moser-Thier, Rabbit chronic ileitis leads to up-regulation of ade-
Javier J. Ferndndez, Maria L. Souto, Javier Dorta, nosine Al/A3 gene products, oxidative stress, and
Federico Diaz-Gonzalez anc l Jesvis Villar immune modulation
Important amino acids for the function of the human Uma Sundaram, Hamdy Hassanain,
MT1 melatonin receptor Zacharias Suntres, Jun Ge Yu, Helen J. Cooke,
Tarja Kokkola, Steven M. Foord, Marie-Ange Watson, Jorge Guzman and Fievos L. Christofi
Olli Vakkuri and Jarmo T. Laitinen
LAAE-14, a new in vitro inhibitor of intracellular
Novel selective and metabolically stable inhibitors of calcium mobilization, modulates acute and chronic
anandamide cellular uptake inflammation
Giorgio Ortar, Alessia Ligresti, Luciano De Petrocellis, Rut Lucas, Mario Alves, Esther del Olmo,
Enrico Morera and Vincenze Di Marzo Arturo San Feliciano and Miguel Paya