Biochemical Pharmacology 2001: Vol 62 Table of Contents

15 Pages·2001·3.1 MB·English

CONTENTS OF VOLUME 62
1 JULY 2001 —_Chiemorierary AND METABOLIC INHIBITORS
81 Selective active site inhibitors of human lactate
Commentary dehydrogenases Ay, }B y, and C
Molecular chaperones and the regulation of neuro- Waa Yas
transmitter exocytosis D ialiaian.9 4. Robert E. Royer, Erwin Goldbere
Konrad E. Zinsmaier and Peter Bronk and Davi
91 Implications of selective type I] IMP dehydrogenase
MOLECULAR AND CELLULAR PHal 1G" (IMPDH) inhibition by the 6-ethoxycarbony]
I: nhibitor of apoptosis-1 (LAP-1) expression and apop- diissuubbssttiittuutteedd-- 11,, ,5-5d-idaizaazbaibciyccylcol|o ]|3.1.Oh]ehxeaxnaen-e2-,2,44 -diones°
al
on tumor cell death
tosis in non-small-cell lung cancer cells exposed to ee ee
citabine
lris H. Hall
Magali Espinosa, Vilma Maldonado =
el] éndeLzy-Z ajgla 101. Imbalanced DN. A y synthesis induced by cytosine ar-
/ tbinoside and fludarabine in human leukemia cells
Functional analysis of the phenobarbital-responsive
unit in rat CYP2B2 Giuseppina M.R. Carbone, Carlo Cataatpaapnaor and
: Janiel -ernand
ing Liu, Ilia Rivera-Rivera, Andr sredemeyen Daniel J. Fernandes
on Kemper 111.) Antioxidant effect of flavonoids after ascorbate/Fe
1D)i etary taurine manipulations in aged male F. ischer induced oxidative stress in cultured retinal 1 cells
, ; SS ee, Ceaee e ee ’ )
344 rat tissue: taurine concentration, taurine biosyn Filipe Miguel Areias, A. Cristina R
thesis, and oxidative m irkers Cat' ari“naan R. Oli| veisreea and ] Rosa Mar5 ia S
bRDd rbelt EF}
Neu
Testosterone-mediated modulation of HERG block-
ade by proarrhythmic agents 119 The effect of aliphatic, naphthenic, oa aromatic
M. Shuba. Vadim E. Destin hydrocarbons on production of reactive oxygen spe-
( \sipenko Valeri G. Naidenov and cies and reactive nitrogen species 1n frat brain synap-
Raymond L. Woosley tosome fraction: the involvement of calcium, nitric
oxide synthase, mitochondria, and phospholipase A
ole of cellular zinc in programmed cell death: ae
: Oddvar Myhre and Frode Fonnum
temporal relationship between zinc depletion, activa-
tion of caspases, and cleavage of Sp family transcrip- 129 Effects of the novel cyclosporine derivative PSC833
tion factors on glucose metabolism in rat primary cultures of
. . UTO o] ;
Fabrice Chimienti, Michel Seve, Sandrine Richard, neuronal and glial cells
Jacques M,e otiaya nd Alain “ei Fatima Cruz and Armin Wolf
A comparative study of cellular and molecular phar-
macology of doxorubicin and MEN 10755, a disac- INFLAMMATION AND IMMUN (
charide analogue i ERE PAR EV ee We aa
- — 141, Involvement of nuclear cna 1 B (NF- KB) ; ac-
rio B on sels Baal
Mario Bigioni, Carmela Salvatore, Angela Bullo, tivation in mitogen-induced lymphocyte prolifera-
Daniela Bellarosa, Elisabetta lafrate, Fabio Animati tion: inhibitory effects of lymphoproliferation by
Giovanni Capranico, Cristina Goso, Carlo Alberto salicylates acting as NF-«B inhibitors
A Pratesi, Franco Zunino and Lucia Cavallini, Maria Angela Francesconi,
} — Franco Zoccarato and Aldolfo Alexandre
71 Induction of cytochrome P450 2B1 by pyrethroids
and in primary rat hepatocyte cultures
Anne F. Heder, Karen I. Hirsch-Ernst, Daniel Bauer, 15 JULY 2001
Georg F. Kahl and Herbert Desel
Commentary
149 Molecular genetics of nucleoside transporters in
Leishmania and African trypanosomes
Scott M. Landfear
CONTENTS OF VOLUME 62
1 JULY 2001 —_Chiemorierary AND METABOLIC INHIBITORS
81 Selective active site inhibitors of human lactate
Commentary dehydrogenases Ay, }B y, and C
Molecular chaperones and the regulation of neuro- Waa Yas
transmitter exocytosis D ialiaian.9 4. Robert E. Royer, Erwin Goldbere
Konrad E. Zinsmaier and Peter Bronk and Davi
91 Implications of selective type I] IMP dehydrogenase
MOLECULAR AND CELLULAR PHal 1G" (IMPDH) inhibition by the 6-ethoxycarbony]
I: nhibitor of apoptosis-1 (LAP-1) expression and apop- diissuubbssttiittuutteedd-- 11,, ,5-5d-idaizaazbaibciyccylcol|o ]|3.1.Oh]ehxeaxnaen-e2-,2,44 -diones°
al
on tumor cell death
tosis in non-small-cell lung cancer cells exposed to ee ee
citabine
lris H. Hall
Magali Espinosa, Vilma Maldonado =
el] éndeLzy-Z ajgla 101. Imbalanced DN. A y synthesis induced by cytosine ar-
/ tbinoside and fludarabine in human leukemia cells
Functional analysis of the phenobarbital-responsive
unit in rat CYP2B2 Giuseppina M.R. Carbone, Carlo Cataatpaapnaor and
: Janiel -ernand
ing Liu, Ilia Rivera-Rivera, Andr sredemeyen Daniel J. Fernandes
on Kemper 111.) Antioxidant effect of flavonoids after ascorbate/Fe
1D)i etary taurine manipulations in aged male F. ischer induced oxidative stress in cultured retinal 1 cells
, ; SS ee, Ceaee e ee ’ )
344 rat tissue: taurine concentration, taurine biosyn Filipe Miguel Areias, A. Cristina R
thesis, and oxidative m irkers Cat' ari“naan R. Oli| veisreea and ] Rosa Mar5 ia S
bRDd rbelt EF}
Neu
Testosterone-mediated modulation of HERG block-
ade by proarrhythmic agents 119 The effect of aliphatic, naphthenic, oa aromatic
M. Shuba. Vadim E. Destin hydrocarbons on production of reactive oxygen spe-
( \sipenko Valeri G. Naidenov and cies and reactive nitrogen species 1n frat brain synap-
Raymond L. Woosley tosome fraction: the involvement of calcium, nitric
oxide synthase, mitochondria, and phospholipase A
ole of cellular zinc in programmed cell death: ae
: Oddvar Myhre and Frode Fonnum
temporal relationship between zinc depletion, activa-
tion of caspases, and cleavage of Sp family transcrip- 129 Effects of the novel cyclosporine derivative PSC833
tion factors on glucose metabolism in rat primary cultures of
. . UTO o] ;
Fabrice Chimienti, Michel Seve, Sandrine Richard, neuronal and glial cells
Jacques M,e otiaya nd Alain “ei Fatima Cruz and Armin Wolf
A comparative study of cellular and molecular phar-
macology of doxorubicin and MEN 10755, a disac- INFLAMMATION AND IMMUN (
charide analogue i ERE PAR EV ee We aa
- — 141, Involvement of nuclear cna 1 B (NF- KB) ; ac-
rio B on sels Baal
Mario Bigioni, Carmela Salvatore, Angela Bullo, tivation in mitogen-induced lymphocyte prolifera-
Daniela Bellarosa, Elisabetta lafrate, Fabio Animati tion: inhibitory effects of lymphoproliferation by
Giovanni Capranico, Cristina Goso, Carlo Alberto salicylates acting as NF-«B inhibitors
A Pratesi, Franco Zunino and Lucia Cavallini, Maria Angela Francesconi,
} — Franco Zoccarato and Aldolfo Alexandre
71 Induction of cytochrome P450 2B1 by pyrethroids
and in primary rat hepatocyte cultures
Anne F. Heder, Karen I. Hirsch-Ernst, Daniel Bauer, 15 JULY 2001
Georg F. Kahl and Herbert Desel
Commentary
149 Molecular genetics of nucleoside transporters in
Leishmania and African trypanosomes
Scott M. Landfear
Volume (¢ ntents, Author and Sul ject Inde X Tor ’
Rapid Communication Hormones AND GROWTHF
Major roles of prostanoid receptors IR and EP, ) in
\ Enzymatic activation of autotaxin by divalent cations
endotoxin-induced enhancement of pain perception
without EF-hand loop region invol
vement
\kinori Ueno Hideki Matsumoto,
J] ATLYS On. L] ee, In Duk Jung, Suk W » Nam
Yuri Ikeda Fumitaka | i] im (4 lair, Eui Myung g Jeong Sung Yeo Hong,
Shuh Narumiya, Yukihiko
Jeung Whan Han Hvang Wi IE e, Mary L StrackCR E
and Sachiko Oh-ishi
| Hoi Young Lee
225 Cyclic GMP eyxwccrreeTttii on blDoicl}o cKed | by isatin administra-
M ( PHARM tion under conditions of fluid overload
Sex-associated expression of mouse hepatic and renal
Ale xel Medvedev, Agnes \ lamik
CYP2B enzymes by glucocorticoid hormones wy '
Gyula Tele ray
mokwan Jarukamjorn, Tsutomu Sakuma,
Yamamoto, Ayako and |
Makot \ | I
Modulation by cellular cholesterol of gene transcrip- 229 Prostaglandin D
receptor-mediated desensitizatio
tion \ ia the cyclic AMP response element of the @ isoform of the human thromboxane
Ali] ya Mi ldlet ; 1 Nury, Susan J \ 7 iIl] iington receptol
ruce Middleton Foley, Leanne P
By-mediated enhancement of corticotropin-releasing rese Kinsella
htiovramtoionne -sotf ima u/-lAaatMeINdO DU{ TaydYeTnIyCl yl cicdy,c larsee ceptacotrisv ityi n bmye ma~c-- 241 cRaardviecdaillo-ls,c avaen ngainntgi hypaenrdt enisriovne- chderluagt inwgi th pr anpI teirotxiieds antof
branes of rat frontal cortex
ICTIVITY
{7n d Maria ( Karl Oettl,
Ernst Haslinger
M RS Gunther J1;u rgens
Troglitazone quinone formation catalyzed by human
and 1 it CYP3A: in atypical CYP oxidation reaction
Kan He, Thomas F. W lf, Erick K. Kinde, Expression and induction of cytochrome P450s in
AnTint E Fielder and Rasmy E | alaat rabbit parotid glands
Yasushi Kikuta, Emi Kusu
Influences of glutathione on anionic substrate efflux Se and
in tumour cells expressing the multidrug resistance- Masamichi Kusunos¢
associated protein, MRP] 255 Oxidation of hydrogen sulfide and methanethiol t
Tanya Bagyij, Antonios Kk kou zas, Stephen B thiosulfate by rat tissues: a specialized function of the
and Margery A DQnb ai1 Y rand colonic mucosa
Cytochrome P450 CYPIBI protein expression: a John Springfield
novel mechanism of anticancer drug resistance DeMaster and Michael D
Morag C.E. McFadyen, Howard L. McLeod,
Fiona C. Jackson, William T. Melvin, 1 AUGUST 2001
Johannes Doehmer and Graeme I. Murray
Activation pathways of 5-fluorouracil in rat organs Commentary
and in PC12 cells 261 Protection against ischemia: a physiological function
Laura Mascia and Piero Luigi Ipata f the renin-angiotensin system
Oo
Jean-Michel Achard, Albert Fournien Hakim Mazourz
Vicente J]. Caride, Paul L Penar,
Leonard A. Fernan ae| z
Volume (¢ ‘ontents, Author and Subject Index for Volume 62, 2001
UL7 AR YD AND CE‘LorLtU LAR P»)H AA RMA4AC OL‘O GY , NEUROSCIENCE
Effects of selected polychlorinated biphenyl (PCB) 349 Molecular cloning and pharmacological characteriza-
congeners on hepatic glutathione, glutathione-re- tion of the ral Sigma, Tec eptol
lated enzymes, and selenium status: implications for
Jianfeng Mei and Gavril W. Pasternak
oxidative stress
Timothy P. Twaroski, Michelle L. O’Brien and
HORMONES AND GROWTH FACTORS
Larry W. Robertson
357 Inducible nitric oxide synthase in rat neutrophils:
Protection against glutamate toxicity through inhibi-
role of insulin
tion of the p44/42 mitogen-activated protein kinase
Graziela A. Cerchiaro, Cristéforo Scavone,
pathway in neuronally differentiated P19 cells
Simone Texeira and Paulina Sannomiya
Elfrida R. Grant, Monica A. Errico,
Stuart L. Emanuel, Daniel Benjamin,
Michael K. McMillian, Scott A. Wadsworth, STRUCTURAL BIOLOGY
Robert A. Zivin and Zhong Zhong 363 Inhibitory effect of quinolone antimicrobial and non-
Hepatic distribution of a phosphorothioate oligode- steroidal anti-inflammatory drugs on a medium chain
oxynucleotide within rodents following intravenous acyl-CoA synthetase
administration Fumiyo Kaswya, Masato Hiasa, Yuichi Kawai,
Mark J. Graham, Stanley T. Crooke, Kazuo Igarashi and Miyoshi Fukui
Kristina M. Lemonidis, Hans J. Gaus,
Michael V. Templin and Rosanne M. Crooke
INFLAMMATION
Identification of a novel C-terminal domain involved Intestinal absorption of rutin in free and conjugated
in the negative function of the rainbow trout Ah forms
receptor nuclear translocator protein isoform a
Wilfried Andlauer, Claudia Stumpf and Peter Fiirst
(rtARNTa) in Ah receptor-mediated signaling
Brian Necela and Richard S. Pollenz
TROINTESTINAL AND RENAL PHARMACOLOGY
Control of survival of proliferating L1210 cells by
Differential effects of isoflurane and halothane on the
soluble guanylate cyclase of p44/42 mitogen-activated
induction of heat shock proteins
protein kinase modulators
Akira Yamasaki, Toru Takahashi, Tsutomu Suzuki,
Flavio Flamigni, Annalisa Facchini, Ivana Stanic,
Tadao Fujiwara, Masahisa Hirakawa, Emiko Ohmori
Benedetta Tantini, Francesca Bonavita and
and Reiko Akagi
Claudio Stefanelli
Functional and toxicological characteristics of iso-
Critical implication of transmembrane Phe310, pos-
lated renal mitochondria: impact of compensatory
sibly in conjunction with Trp279, in the rat gonado-
renal growth
tropin-releasing hormone receptor activation
Lawrence H. Lash, David A. Putt,
Stéphanie Chauvin, Marcel Hibert, Annette Bérault
Stanley J. Horky III and Rudolfs K. Zalup
and Raymond Counis
Additions and corrections
AND METABOLIC INHIBITORS
Action of the novel antioxidants 4GBE43 and 15 AUGUST 2001
2BBE43 against lipid peroxidation
Tomonobu Ezure, Toshiji Kanayama and Commentary
Chikao Nishino
Neurotransmitters and apoptosis in the developing
Structure-activity relationships and inhibitory effects brain
of various purine derivatives on the in vitro growth of Chrysanthy Ikonomidou, Petra Bittigau,
Plasmodium falciparum Christian Koch, Kerstin Genz, Friederike Hoerster,
Leonie Harmse, Robyn van Zyl, Nathanael Gray, Ursula Felderhoff-Mueser, Tatyana Tenkova,
Peter Schultz, Sophie Leclerc, Laurent Meijer, Krikor Dikranian and John W. Olney
Christian Doerig, Ivan Havlik
Volume Contents, Author and Subject Index for Volume 62, 2 1729
MOLE \R AND CEI AR PHARMACOLOG' 469 Inhibition of export of fibroblast growth factor-2
(FGF-2) from the prostate cancer cell lines PC3 and
Oxidation of prostaglandin H, and prostaglandin H
ae DU145 by Anvirzel and its cardiac glycoside compo-
analogues by human cytochromes P450: analysis of
nent, oleandrin
w-side chain hydroxy metabolites and four steroiso-
mers of 5-hydroxyprostaglandin |, by mass spectrom- \. Smith, Timothy Madden, Mary Vijjeswarapu
d Robert A. Newman
etry
Ernst H Oliw, Katarina Stark and Johan Bylund
NEUROS
417 Verapamil-stimulated glutathione transport by the
multidrug resistance-associated protein (MRP1) in 473 6-Hydroxydopamine-induced nuclear factor-kappaB
ictivation in PC12 cells
le ukaemia cells
Karen V. Cullen, Ross A. Davey and ] David Blum, Sakina Torch Marie-France Nissou and
Mary W Jean-Marc Verna
Inhibition by guanosine cyclic monophosphate
(cGMP) analogues of uptake of [°H]3’,5’-cGMP
CARDIOVASCULA \ND PULMONARY PHARMA
without stimulation of ATPase activity in human
483 Inhibition of stress-activated protein kinase in the
erythrocyte inside-out vesicles
ischemic/reperfused heart: role of magnesium tanshi-
Emmanuel Boadu, Svanhild Vaskinn, noate B in preventing apoptosis
Elisabeth Sundkvist, Ragnhi} ld Jaeger and Georg Sager
Kathy K. W. Au-Yeung, Da-yuan Zhu,
431 Agonist-induced functional desensitization of recom- Karmin O and Yaw L. Siou
binant human 5-HT2 receptors expressed in
CHO-K1 cells
INFLAMMATION AND IM)
Richard H. P. Porter, Craig S Malcolm, 495 Regulatory roles of adenylate cyclase and cyclic nu-
Nicola H Allen, Helen Lamb, Dean F. Revell and
cleotide phosphodiesterases 1 and 4 in interleukin-13
Malcolm J Sheardown
production by activated human T cells
439 Effect of metformin on fatty acid and glucose metab- Naoko Kanda and Shinichi Watanabe
olism in freshly isolated hepatocytes and on specific
gene expression in cultured hepatocytes
GASTROINTESTINAL AND RENAL PHARMACOLOGY
Jean-Pierre Fulgencio, Claude Kohl, Jean Girard and
JJJeeeaaannn--- IP aul Pégorier 509 = Attenuation of liver normothermic ischemia-reperfu-
sion injury by preservation of mitochondrial func
447 yw Opioid receptor-mediated G-protein activation by
tions with S-15176, a potent trimetazidine derivative
heroin metabolites: evidence for greater efficacy of
Aziz Elimadi, Rosa Sapena, Abdellatif Settaf,
6-monoacetylmorphine compared with morphine
Herve Le Louet, Jean-Paul Tillement and Didier Morin
Dana E. Selley, Cheng-Chun Cao, Tammy Sexton,
Jennifer A. Schwegel, Thomas J. Martin and
Steven R. Childers
457 Effect ot lipopolysaccharide (LPS)-evoked host de-
fense activation on hepatic microsomal formation Commentary
and reduction of sulfamethoxazole hydroxylamine in 517 Fatty acid amide hydrolase: biochemistry, pharmacol-
the rat ogy, and therapeutic possibilities for an enzyme hy-
Alastair E. Cribb, Timothy McQuaid and drolizing anandamide, 2-arachidonoylglycerol, palmi-
Kenneth W. Renton toylethanolamide, and oleamide
Christopher J. Fowler, Kent-Olov Jonsson, and
(CHEMOTHERAPY AND METABOLIC INHIBITORS Gunnar Tiger
461 Involvement of NADPH: cytochrome P450 reductase
in the activation of indoloquinone EO9 to free
radical and DNA damaging species
Susan M. Bailey, Alex D. Lewis,
Laurence H. Patterson, Geoff R. Fisher,
Richard J. Knox and Paul Workman
Volume Contents, Author and Subject Index for Volume 62
_M LEK \R AND CELLULAR PHARMACOLOGY 603 S phase dependence and involvement of NF-kappaB
activating kinase to NF-kappaB activation by camp-
Effects of ( eee igalloc allie Sele the main
tothecin
component of green tea, on the cloned rat brain
Kv1.5 potassium channels Yvette Habraken, Bernard Piret, and Jacques Piette
Bok Hee Choi, Do Sik Min, Shin Hee Yoon,
Duck-Joo Rhee ; Yang-I lyeok JJ O, Myung-Suk Kim GENE EXPRESSION AND DEVELOPMENTN i
and Sang June Hahn
Pulmonary CYP1A1 and CYP1A2 levels and activi-
Regulation of agonist binding to rat ET, receptors by ties in adult male and rato offspring of rats exposed
cations and GTPyS during gestation and lactation to 2,3,7,8-tetrachlo-
Francesca Ceccarelli, Laura Giusti, Gianni Bigini, rodibenzo-p-dioxin
Barbara Costa, Dante Grilloti, Erika Fiumalbi, Michael M. a and Jacq teline Fung
Antonio Lucacchini, and Maria Rosa Mavzzoni
Delivery of cholesteryl-conjugated phosphorothioate
oligodeoxynucleotides to Kupffer cells by lactosylated
Shortcuts In genome-scale cancer pharmacology re
search from multivariate analysis of the National low-density lipoprotein
Cancer Institute gene expression database
Meu tin K Bi) jsterab osch1, Muthiah Manoharan,
Giuseppe Musumarra, Danielle F. ( ondorelli land Ingrid H.E. Waarlo, Erik A.L Biessen,
Salvatore Scire, and Alessandro S. C OoStda l Thn eo J a ’. van Berkel
Potential application of plant lipid transfer proteins A study of the expression of the xenobioticmetabolis-
for drug delivery ing cytochrome P450 proteins and of testosterone
Christine Pato, Mar Le Borgne, Guillaume Le Baut metabolism in bovine liver
Patrice Le Marion, and Jean-Paul Douliez Susila Sivapathasundaram, Paraskevi Magnisalik,
Nick G. Coldham , Laurence ( . Howells,
The absence of stereoselective P-glycoprotein- and
Maurice J. Sauer, and Costas Ioannides
multidrug resistance-assoc iated pre ytein-mediated
transport of daunorubicin
Chatchanok Loe tchutinat, Christine Heywang, 15 SEPTEMBER 2001
Waldemar Priebe, and Arlette Garnier-Suillerot
Commentary
CHEM THERAPY ND METAI NHIBITORS Chemoprotection from p53-dependent apoptosis: po-
tential clinical applications of the p53 inhibitors
Bade weed ictivity of antisense sis IStP ech thioate oli-
gos against Leishmania amasitgotes: augmented uptake Elena A. Komorova and Andrei \ Gudkor
of oligo, ribonuclease H activation, and efficient
target intervention under altered growth conditions
MOLECULAR AND CELLULAR PHARMACOLOG} ry
Manjari Mishra, Johanna M. Porter-Kelley,
Identification of a 43-kDa protein human liver
Pramod K. Singh, Jabbar R B]e nnett, and
cytosol that binds to the 3’-untranslated region of
Gautam Chaudhuri
CYP2A6 mRNA
AP-1 activation and altered AP-1 composition in James Gilmore, Francesca Rotondo,
association with increased phosphorylation and ex-
Anne-Marie Pell tier, Jonathan LaMarre,
pression Of specific Jun and Fos family proteins Moulay / \laoui-Jamali and Gordon M. Kirby
induced by vinblastine in KB-3 cells
Inhibition of extracellular Ca“* entry by YC-1, an
Mary Goodwin, Cindy L. Moran, and
activator of soluble guanylyl cyclase, through a cyclic
Chambers
GMP- independent pathway in rat neutrophils
993 Suppression of c-myc expression and c-Myc function
Jih-Pyang Wang, Ling-Chu Chang, Li-Jiau Huang and
in response to sustained DNA damage in MCF-7 Sheng-Chu Kuo
breast tumor cells
Karen J. Magnet, Michael S. Orr, John L.
( les eland,
Carlos Rodriguez-Galindo, Hui Yang, Chunying Yang,
Yong-Mei Di, Pramod T. Jain, and David A. Gewirtz
Volume Contents, Author and Subject Index for Volume 62 1731
685 Comparison of the mutant frequencies and mutation 755 Antitumor effectso f ajulemic acid (CT3), a synthetic
spectra of three non-genotoxic carcinogens, oxaze- non-psychoactive cannabinoid
pam, phenobarbital, and Wyeth 14,643 at the Acl] Lawrence D Rebecca Salmonsen,
Recht
locus in the Big Blue trans genic mice Rone ild Rosetti, Tai Jang, George Pipia
Vijaypreet K. Singh, Loga Ganesh, Tomacz Kubiatowski, Push 1 Karim, Alonzo H ISS
Michael L. Cunningham and Barbara S. Shane Robert Zurie? N. Scott Litofsky and Sumner Burstein
MDR!1 bicistronic vectors: analysis of selection strin- Effects of miltefosine on various biochemical param-
gency, amplified gene expression, and vector stability eters in a panel tumor cell lines with different
in cell lines SeNsItIVITies
Susan E. Kane , Linda Matsumoto, Marianne Z. Metz, Maria Ryl crynska
Cecile A. Donohue, Robert G. peas N» orbert G Giinther
Knebel
Sharon W. Lin and James H. Doroshou Hans Grunicke and Johann Hofmann
tert-Buty| hydroperoxide-induced lipid signaling in P450 interaction with farnesyl-protein transferase
hepatocytes: involvement of glutathione and free inhibitors Metabolic stability, inhibitory px tency,
radicals ind P450 binding spectra in human liver microsomes
César Martin, Rosa Martinez, Ros« wra Navarro Masato Chiba, Cuyue Tang, William E
José Ignacio Ruiz-Sanz, Merc edes Lacort and Theresa M. W iliame S ‘vail Desolms
I3 egona Ruiz-Larrea Christopher J. Dinsmore, John S. Wai and
Jiunn H. Lin
Relationships between non-occupational cadmium
exposure and expression of nine cytochrome P450
forms in human liver and kidney cortex samples GENE EXPRESSION AND DEVI
Jason R. Baker, Soisungwan Satarug, Quantification and cellular localization of expression
aul E.B. Reilly, Robert J. Edwards, in human skin of genes encoding flavin-containing
Noritaka Ariyoshi, Tetsuya Kamataki, monooxygenases and cytochromes P450
Michael R. Moore and David J. Williams
Azara Janmohamed, (¢ olin T Dolphin, Ian R. Phillips
Differential signalling of both wild-type and Thr- and Elizabeth A Shep hard
* Arg dopamine D receptor by partial agonists
1 a G-protein-dependent manner
INFLAMMATION AND IMMUNOPHARMA(
Petrus J. Pauwels, Stéphanie Tardif and
Oxidant-mediated lung epithelial cell tolerance: the
Francis C. Colpaert
role of intracellular glutathione and nuclear factor-
Salvicine, a novel DNA topoisomerase II inhibitor, kappaB
exerting its effects by trapping enzyme—DNA cleav-
Irfan Rahman, Brigitte Gilmour,
Mulier, Peter S
age complexes Tammy Watchom, Kenneth Donaldson,
Ling-hua Meng, Jin-shen Zhang and Jian Ding Peter K. Jeffrey and William MacNee
Oxidative stress in rheumatoid uthritis leukocytes: Inhibition of inflammatory cytokine production and
suppression by rutin and other antioxidants and lymphocyte proliferation by structurally different ses-
chelators quiterpene lactones correlates with their effect on
activation of NF-KB
Elena A. Ostrakaovitch and Igor B. Afanas’ea
Egon Koch, Christoph A. Klaas, Peter Riingeler,
Victor Castro, Gerardo Mora, Walter Vichnewski
’ METABOLK INHIBITORS
and Irmgar ‘d Merfort
Suppression of cytokine production and neural cell
death by the anti-inflammatory alkaloid cepharan- ier, rant ‘
CARDIOVASCULAR AND MONARY Pt OLOGY
thine: a potential agent against HIV-1 encephalopa-
thy Increase in hepatic expression of SREBP-2 by gemfi-
Mika Okamoto, Minoru Ono and Masanori Baba brozil administration to rats
Niiria Roglans, Cristina Peris, Juan C. Verd,
Marta Alegret, Manuel Vazquez, Rosa M. Sanchez
and Juan C. Laguna
Volume Contents, Author and Subject Index for Volume 62, 2001
1 OCTOBER 2001 913 Role of G-protein availability in differential signaling
by alpha 2-adrenoceptors
Commentary Johnny Nasman, Jyrki P. Kukkonen, Sylwia Ammoun
Antiproliferative prostaglandins and the MRP/GS-X and Karl E. O. Akerman
pump role in cancer immunosuppression and insight
Effects of tolbutamide and N-benzoyl-p-phenylala-
into new strategies in cancer gene therapy
nine (NBDP) on the regulation of [Ca**]; oscillations
Paulo Ivo Homem de Bittencourt, Jr. and Rui Cur in mouse pancreatic islets
Sigurd Lenzen and Thomas Peckmann
MOLECULAR AND CELLULAR PHARMACOLOGY Altering behavioral responses and dopamine trans-
Mechanism of apoptosis in HL-60 cells induced by porter protein with antisense peptide nucleic acids
n-3 and n-6 polyunsaturated fatty acids
Beth M. Tyler-McMahon, Jennifer A. Stewart,
Kayo Arita, Hirotsugu Kobuchi, Toshihiko Utsumi, Joshua Jackson, M. D. Bitner, Abdul Fauq,
Yoshiki Takehara, Jitsuo Akiyama, Alan A. Horton Daniel J. McCormick and Elliott Richelson
and Kozo Utsumi
Apparent capacity of cardiac muscarinic receptors for (CHEMOTHERAPY ANI METABOLK INHIBITORS
different radiolabeled antagonists
Pharmacokinetic parameters and mechanisms of in-
Chi Shing Sum, Norman Pyo and James W. Wells hibition of rat type 1 and 2 steroid 5a-reductases:
different in vivo
Metabolic alterations by clofibric acid in the forma- determinants for activities of
G1198745 and finasteride in the rat
tion of molecular species of phosphatidylcholine in
rat liver J. Darren Stuart, Frank W. Lee,
Deborah Simpson Noel, Sue K. Kadwell,
Hiroki Mizuguchi, Naomi Kudo and Yoichi Kawashima
Laurie K. Overton, Christine R. Hoffman,
Effect of tributylin chloride on the release of calcium Thomas A. Kost, Timothy K. Tippin,
ion from intracellular calcium stores in rat hepato- Russell L. Yeager, Kenneth W. Batchelor and
cytes H. Neal Bramson
Toru Kawanishi, Takehito Kiuchi, Hiroki Asoh,
Rie Shibayama, Hiroshi Kawai, Hisayuki Ohata,
NEUROSCIENCI
Kazutaka Momose and Takao Hayakawa
Characterization of ginseng saponin ginsenoside-Rg,
Requirement for GSH in recycling of ascorbic acid in
inhibition of catecholamine secretion in bovine ad-
endothelial cells renal chromaffin cells
James M. May, Zhi-chao Qu and Xia Li
Eiichi Tachikawa, Kenzo Kudo, Masaki Nunokawa
Interaction of azimilide with neurohumoral and Takeshi Kashimoto, Eiji Takahashi
channel receptors and Shuji Kitagawa
Robert R. Brooks, Schwe Fang Pong, Nicholas J. Izzo,
Thomas J. Mo yrehead , Murali Gopalakrishnan and HORMONES AND GROWTH FACTORS
David J. Triggle
Transcriptional activities of estrogen receptor
Early effects of AZT on mitochondrial functions in and beta in yeast properties of raloxifene
the absence of mitochondrial DNA depletion in rat Elisabeth Jisa, Eva Dornstauder, Sumito Ogawa,
myotubes Sathoshi Inoue, Masami Murumatsu and
Ornella Cazzalini, Maria C Lazzé, Luisa lamele, Alois Jungbauer
Lucia A. Stivala, Livia Bianchi, Patrizia Vaghi,
Antonia Cornaglia, Alberto Calligaro, Daniela Curti,
Andrea Alessandrini, Ennio Prosperi and Vanio Vannini INFLAMMATION AND IMMUNOPHARMACOLOGY
Effects of Ginkgo biloba extract (EGb 761) and quer-
Inhibitory effects of helenalin and related compounds
cetin on lipopolysaccharide-induced signaling path-
on 5-lipoxygenase and leukotriene C, synthase in
ways involved in the release of tumor necrosis factor-a
human blood cells
Teri L. Wadsworth, Tasha L. McDonald and
Susanne Tornhamre, Thomas J. Schmidt, Dennis R. Koop
Barbro Nésman-Glaser, Inger Ericsson and
Jan Ake Lindgren
Volume Contents, Author and Subject Index for Volume 62, 2001 1733
15 OCTOBER 2001 Inhibition of phosphoenolpyruvate carboxykinase
(PEPCK) gene expression by troglitazone: a peroxi-
Commentary some proliferator-activated receptor y (PPAR-y)-in-
dependent, antioxidant-related mechanism
Atomic force microscopy as a novel pharmacological
Gerald F. Davies, Ramji L. Khandelwal,
tool
Lingyun Wu, Bernhard H. J. Juurlink
Ricardo de Souza Pereira
and William J. Roesler
Stimulation of gap junctional intercellular communi-
MOLECULAR AND CELLULAR PHARMACOLOGY
cation by thalidomide analogs in human fetal skin
Cellular pharmacology of cerulenin analogs that in-
fibroblasts (HFFF2) and in rat liver epithelial cells
hibit protein palmitoylation (WB-F344)
Mackenzie L. De Vos, David §. Lawrence and
Duygu Onat, Wilhelm Stahl and Helmut Sies
Charles D. Smith
Sequestration and phosphorylation of the prostaglan-
(CHEMOTHERAPY AND METABOLIC INHIBITORS
din E, EP, receptor: dependence on the C-terminal
Differential regulation of phosphatidylserine exter-
tail
nalization and DNA fragmentation by caspases in
Deborah Slipetz, Stephanie Buchanan,
anticancer drug-induced apoptosis of rat mammary
Cameron Mackereth, Natalie Brewer,
adenocarcinoma MTLn3 cells
Vanessa Pellow, Chuan-ming Hao,
Merei Huigsloot, Ine B. Tijdens, Gerard J. Mulder
Mohammed Adam, Mark Abramovitz
and Bob van de Water
and Kathleen M. Metters
Cisplatin-induced apoptosis by translocation of en- The cytostatic- and differentiation-inducing effects of
cyclopentenyl cytosine on neuroblastoma cell lines
dogenous Bax in mouse collecting duct cells
Jérgen Bierau, Albert H. van Gennip,
Ryang Hwa Lee, Jin Mi Song,
Jozien Helleman, and André B. P. van Kuilenburg
Mi Young Park, Soo Kyung Kang,
Yong Keun Kim and Jin Sup Jung
HORMONES A JROWTH FACTORS
Induction of CYP2B1/2 and nicotine metabolism by
ethanol in rat liver but not rat brain Stimulation of ERK2 by taurine with enhanced alka-
line phosphatase activity and collagen synthesis in
Kerri A. Schoedel, Edward M. Sellers
and Rachel F. Tyndale osteoblast-like UMR-106 cells
Sungyoun Park, Harriet Kim and Sung-Jin Kim
Roles of long chain fatty acids and carnitine in
mitochondrial membrane permeability transition
Takashi Furuno, Tomoko Kanno, Kayo Arita, GENE ExPRESSION AND DEVELOPMENTN i
Maki Asami, Toshihiko Utsumi, Yoshinori Doi, Involvement of a post-transcriptional mechanism in
Masayasu Inoue and Kozo Utsumi the inhibition of CYP1AI expression by resveratrol in
breast cancer cells
Domains of the parathyroid hormone (PTH) receptor
required for regulation by G protein-coupled receptor Jeong-Eun Lee and Stephen Safe
kinases (GRKs)
Patrick J. Flannery and Robert J. Spurney INFLAMMATION AND
Catalytic inhibition of human DNA topoisomerase Participation of Ca~~/calmodulin during activation
Ila by hypericin, a napthodianthrone from St. John’s of rat neutrophils by polychlorinated biphenyls
wort (Hypericum perforatum) Jesus Olivero and Patricia E. Ganey
Katherine A. Peebles, Ronda K. Baker,
Further evidence for the involvement of inhibition of
Ebba U. Kurz, B. J. Schneider
cell proliferation and development in thymic and
and David J. Kroll
splenic atrophy induced by the peroxisome prolifera-
tor perfluoroctanoic acid in mice
Qian Yang, Yi Xie, Anna Messing Eriksson,
B. Dean Nelson and Joseph W. DePierre
Volume Contents, Author and Subject Index for Volume 62
1211 Regulation of human B,-adrenergic receptors and
their mRNA in neuroepithelioma SK-N-M¢ ’ cells:
Role of tumor necrosis factor-alpha in endotoxin-
Effects of a gonist, forskolin, and | rotein kinase A
induced lung parenchymal hyporesponsiveness in
Suleiman W. Bah uth, Kevin M. Sowinski and
mice
John J. Lima
ura Brandolini Assunta ti Intil
Gianfranco Case li and Riccard Reduction in dermal fibrosis in the tight-skin (Tsk)
mouse after local ea ation of halofug none
ASTROINTEST OG’ Mark Pines, Avraham Domb, Meir Ohana,
Jacob Inbar, Olga Genina Rosaly \lexiev and
The impact of different flavonoid classes on colonic
Arnon Nagle:
CI secretion in rats
Rainer Cermak, Zoran Vujicic, Erwin Scharrer and Inhibition of depolarization-induced [’H] noradrena-
line release from SH-SY5Y human neuroblastoma
Sieg} ied W f yifram
cells by some second-generation H receptor antago-
nists through blockade of store-operated Ca~* chan-
1 NOVEMBER 2001 nels (SOCs)
Maurizio Tagli: ulatela, Agnese Secondo, Angela Fre i
Commentary Barbara Rosati, Anna Pannaccione
Taming platelets with cyclic nucleotides Pasqualina Castaldo, Gio vanna Giorgio, Enzo Wanke
and Lucio Annunvziato
Ulrike R. Schwarz, Uh ich Wal ter and
Martin Eigenthaler LAaCc k OTF of corret|a tion ID etween tIhe obIs erved | stabbiilliitty
and pharmacological properties of S-nitroso deriva-
tives of glutathione and cysteine-related peptides
Jayne M. Tullett, Daryl D
= of human mast cell activation with the Andreas Geschen
novel selective adenosine A,,
receptor antagonist
}- isobut yl- o p yrrolidinox: unthine (IPDX) CHEMOTHERAPY AND METABOLIC INHIBI
Igor Feoktistov, Emily M. Garland,
ae
Anna E Goldstein, Dewan Zeng, Luiz Be -lardinelli , 1249 Pharm: wich gical preconditioning with doxorubicin:
Jack N Wells and Italo Biagg onl Implications of heme oxygenase-! induction in doxo-
rubicin-induced hepatic injury in rats
Effects of purified green and black tea polyphenols on
cyclooxygenase- and lipoxygenase-dependent metab Koji Ito, Hisashi Ozasa, Yoji Nagashima,
olism of arachidonic acid in human colon mucosa and Kiyokazu Hagiwara and Saburo Horikawa
colon tumor tissues Novel 6-substituted uracil analogs as inhibitors of the
Jungil H ong, Theresa J. Smith, angiogenic actions of thymidine phosphorylase
David A. August and Chung S. Yang Robert S. Klein, Michelle Lenzi, Timothy H Lim,
Effects of naturally occurring prenylated flavonoids Kylie A. Hotchkiss, Phyllis Wilson and
on enzymes metabolizing arachidonic acid: Cyclooxy- Edward L. Schwartz
genases and lipoxygenases
Yeon Sook Chi, Hyon Gun Jong, Kun Ho Son,
son Wook Chang, Sam Sik Kang and
Protective effect of nimodipine on dichlorvos-in-
H yun yo Kim duced delayed neurotoxicity in rat brain
Molecular cloning and functional characterization of Sanjeev Choudhary and Kiran Dip Gill
murine cysteinyl-leukotriene | (C y ~ a ) receptors Morphine-6B-glucuronide and morphine-3-glucuro-
Viviane Martin, Nicole Sawyer, Rino Stocco, nide, opioid receptor agonists with different potencies
David Unett, Michael R. Lerner, Mark Abramovitz
and C lin D. Funk Chris | lens, Lanning Baker, Anna Ratka,
Dieter Waumans and Jan Tytgat
Metabolism of tirapazamine by multiple reductases in
the nucleus
Y vette M. Delahoussaye, James W. Evans and
J. Martin Brown