Table Of Content

AUTHOR INDEX rbakke, J., Boelaert, J. R., Abid, A., 965 Bonanomi, A Borde-Chiché Bornheim, | saldwin, IsScCadIlCeSs, MiVVi ., asell11i , U.‘ , Barouki, R., 511 cignanl, Barrett, M. P., Bar-Tana, J., g 71 Bast, A., 715 ‘haudhuriG,. , Bauer, C., 1049 relli, B., 5 Begleiter, A... Belcourt, M. Bennett, |. Benson, R Smedt, H., 803 Berge, K., ¢ Smet, K., 1293 Berge, R. K.., Smet, P., 8C Bergman, / ‘heon, B. S., 5 ssouza, 1., 130 Berman, I., ‘heong, Y.-P., de Vries, E. G Bertini, R., heung, F., 5 Dewit, ]., 1313 Beryt, M., i. 0. ok : Di Bartolomeo, S., Best, L., 13 ‘hiang, H.-T.., Dicato, M., 605 Bidlack, J vhiba, Y., 92 Diedrich, M.., Billack, B., ‘ho, C. H., 3 Dieter, M. Z., Bizer, C RRr/ Ar‘RRh oRR, A DD.A, D Dietl, P., 1161 Bizzarri, C., 142 Cho, M. Diez-Fernandez, C Black, J. D., 1093 Choi, B. H., 1029 Digby, T. ]., 955 Blask, D. E. 55 Choi, E., Ding, B. C., 665 Blom, N., Choi, J.-S., 102 Dinsdale, D., 493 Bock, C., 119 Choi, S.-Y., Dirsch, V. M., 587 ] jonzsea lelze- Ramon, rN .., rf yhnston, G., 893 I joossens, | I 9 99 if mes, D« oS jorman, N., 84 4 Jo uzeau, | a I ) ohert Junquero, Dol Jupp, O Durini iremigni, V., Dyroy, E., iroziak, M. P Dziegielewski, Guardiola-Diaz ,H Guguen-Guillouzo, Edwards, ¢ Guillouzo, A., 1 387 Ekelund Guo, Q., 547 aD eee Erba, F., 2 Haenen, G Eriksson, Hagiw ifa, K Hahn, S. J., 102 Halbfinger, Hall,| I icchini, Haller, Facompre, } Han, | Fairlie, D Han, |] Fajardo, I., 1 Han, 1. 3 Falissard, B Hanas, ] Falleni, A Hanas, R Fang, X., Harg vreaves, I irdel, O Hayashi, H Farrell, ¢ Heck, D. e., Kimiagar I ivre, | Heffron, J. A., Klu t tugmann, Fernandez, } Heng, H., 665 Klupsch, F Fierens, Herbert, Ko, H. H Fiorucci, Hertz, R., Koba, M 61 Fischer, Hider, R \. R., 199 Fiume, | Hines, R Ke yhmutor ’ , 343 Fllatatm,i gPn.i ,| Hiraku, Y., 35 Kondo 319 Folkes, L. K., 1 HHoo, , \j. ¢ 3 KK oom Mopa, , , 61854 39 FFoonrtt nienya,, JM.. ,E. , | HHooecbkheer,, K] KKo rskhiinha , ifa |5 .g3y. , ORoDid FForsatnerc,o -P|e nte«aadeo , 4(4 3 Fs 120\ 5 HHooflmfemsa,n , Kourounak i A. 1357 Fredh« Im, B B Holmsen, Freshwater, Huang, P., Frey, M. R., Hukku, B., Frey, R. S., 97 Hunter, |., Frick, M., 1161 Hw inv, Fridkin, M., 10 Fruchart, J.-¢ lacobini, M., Kuroki, K., Ibragimova, G Kuznetsov Ganap ithi, } Ichikawa, A., 1153 GGaanntahpeart,h i,H CIecjhkiak,a waD,. , T8.,1 7 117f7f agicukneay,, L|D ) Cc Gao, F., 857 ljzerman, Ad. P cam, V., 7 Q5 Garcia-Trevijano, Ikeda, M 7 i aplace, M.- Gardner, ¢ Ikeda, R., 1339 -arrarte, "a Geissinger, keda, Y., 911 -arsson, ¥ | Gekker, G., askin, D. lrenius, E.. Gialluca, N _askin, J. | Gibson, L Ishikaw 1, | -atasa, M. | Gidrol, X., 3 Jacobson, K Laubinger, W., 623 Gilad, G Jan, C.-R., Laychock, ee Gz. Gilad, \ lang, Y. Y., Ledirac, N., 399 Gilot, D., 1 — P. B.. 1401 Lee, B., Giordano, Ji, X E57 Lee, C. S. 87i Giraldi, T Se E., 557 Lee, H. W., Goldberg, Jin, H. K., 90 Lee, H. } 0 3 Goldenbers Jo, Y.-H., 1029 Lee, J. c , 1561 Goldman, Johannes, E.., Lee, ae ee 1537 Goldschmidt, E Johnson, K. L., Lee, K.-M., 779 fedina, M. A., Li Ob-ishi, Q Meht i, Oo. , 1517 Yhuchid i Meijer, C., 573 ikawa, Menegatti, 7 Menichelli, letzger, ‘ Miao, Z., 915 Mikhal’chik, Miller, R Milovic, ‘ Min, D Minn, ichtenberge Misawa, h ieke ns, S Mishra, inden Miss=iaaet\ \V . | in-Lee, Muceniece, Mulder, Mulder, Mult ifl, I MM unch-Peterset | iMVu‘i nunsseey , I Mushrt | I N ivasawa, I Ni welkerke, | Manfredini, Naraba, H., ‘ I Marder, P., Narumiy Pilon, Margareto, Navarra, P., 437 Pined Marshman, N vvlor, F P Marti, A., Nebert, [ Martin, E Nédélec, F Ple Martinez, M. (¢ Neef, G., 893 P iun ket, Martini, C., 695 Négre-Aminou P)x Martrinez, ]. A., Neijt, H., 343 |w sT tog- se, Marunaka, Netter, P 7 Pe- otertiek . Maruyama, T Newell, I |- ozzoli, Maruyama, Y J Pr ibonnz wud, Mascagni, P Pratesi, G Matherly, L. H., 665 Presle N.,P $ Mato, J. M., 1119 Nienhuis, E. F., 3 Preziosi, Matsuda, A., 1497 Niisato, N., 761 Pritsos, C Matsui, H., Nijmeijer, S. M., 37 Pritsos, KD W., 893 Mays, D. C Nixon, G. F., 74! Prosser, Mazerska,Z Nosjean, O., 13 Przedeck if 565 -_ McClenaghan, N Nwosu, E. C., 3 Puga, A ,»O VD McFarlane, S. M., 749 Nygren, P McIntosh, J. M., 1479 Rabey, ] M., cLean, W. G., 409 O’Brien, N Rahman i R., McPherson, J. P., 795 oO" iiatee, Y. a= 7 Randriat nhD .,a VO4N4I9Y , Medina, D., 311 Oh, J., 779 Rattendi, Author Inc lex | Bioc hemical Pharmacolo]g y 6 Shinomiya, S., 1153 Tegeder s 651 Shiono, Y., 1339 Teixeira, S. A., 1305 Shpakov, A. ©: 1277 Teng, C.-M., 939, 947 Reichel, Siber 1161 Terlain, B., 965 Reid, M. Siderovski, D. P., 1329 Te Sta, B 122 a Reiser, G - 62 Silva, A 1. Thiami ra, Ribeiro-DaSilva Simon, H.- Theobald, d Rockwell, S., Sinclair, J F Theron, A. . 1319 Rodgers, |. i Sinclair, ei, Thomas, C., 595 Rodriguez, C Singleta ry, K. W Thomas, H. D., 477 Rodriguez de la ConcepIc ion, } Sinha, R., 311 Thomer, O. A. R., 1347 Sinzinge bbb OF Thomson, T. Roggeman, C., 1227 Sinzinge ce MM, 51 Thornalley, Rogiers, \ on 1073, 1107, Siow, K O., 50 >3 Thum, T., Roglans, N., 357 Si yw, Y. bs fy Tillement, Rolo, A. P., 1449 Sipma, I :. Timar, T. G., Romualdi, P., 1409 Sivapras 2 One», f Tintinger, G. R.., Rosati, A., 61 Skladanowski, Tirosh, O., 547 Rose, S., 285 Slamon, DD, Tisch-Idelson, D., 1063 Rosei, ) Togari, A., 319, 579 Ross, Tomasz, M., 1517 Ruuth, Tonetti, C., 867 Rybicki,| Smith, Torpier, .J.. 387 429 Smith, Transidico, P., 1 Sadler, ¢ Smith, S. L., Treré, - Saito, L., So, H.-S Trev es, Sakai, Soares-da-Silva, Trineali, G.. Saldeen, Sobal, ¢€ ~e t 297e e Tronstad, K. Salech, S., Solis, W. A Tschirhart, Salel, \ Son, ¥., 77 Tseng, L.-L., Salmena, Sondek, Tsuboi, T., 57 Salvetti, F Song, D.-L., Tungodden, L Salvi, A., Sozzani, Turchanowga, Sanche1 z, R opasc ‘ko ukotskaja, T. 19] Sanchez, T., 811 Sperber, he. 550% Jeno, A., 911, Sanchez-Jimenez, Spinedi, A., 851 nni, E., 311 Sanderlin, D., 5 Spitzbar th-Régrigny, E , 485, 1169 rdiales, J. L., Sanderson, S Srinivas an, C., 245, 9)2 ) 5 Jrwyler, S., 343 Sandrini, M., Staels, I5 ., 387 Jshikubi, F., 1153 Santos, D. J Staub, {., 191 tsunomiya, I., 1153 Sartorelli, Pp otet nel li,¢ Sasvari-Szék Stein, J., 199 1rano, M ’ 437 Sauer, | A oteinme yer, A indenabeele, P., 749 Savaral], St{i o, M., 365 undeputte, C., 485 Savi, I clet, J.-C ai in det hey den, I Sayre, P., Streubel, €s.. ¢ in der Meulen, H Schaeffer, P Stroud, R. M., in Erck, M., 991 Schiifer, R., Sufrin, J in Haaften, Sch IPOW il, ougimot , inhaecke, fi Schilf, A., Sugiyama, 4@ ¢in ALéee ngoed, | Schos nberg, owann, ee V an Leeuwe nN, R Schrier, S. Oweitzer, inlingen, S., R 803 Schroeder, Sy dnes, bey OME - in Luyn, M. J. A., 573 Schiller, S., 119 Sylte, I., 70 an Miert, A. S. J. P Schulte, G., 443 a“<a nquelin, G., 277 Schulze-Osthoff, K., 119 Takeucl 1Ccl, T in Tilburg, E. W Sehested, M., 1401 Talianic lis, I., — a, E227 eo, H.-K., 787 Tan, Y , 867 A, DD. Y= 1463 Sergeeva, M.., Tanaka, azeux, G., Shankar, V. N., 893 Tang, L A. ‘Azquez Sharp, S., 1107 Tantini, B:, 25 eerman, G. Sheader, E. A., 1381 Taramelli, D., 999 /ercruysse, A., 1073, | Sheena, \ 1057 Tarayre, b. ,) <84=. V_ a=e<r n het, L., 1387 Shen, M. L., 537 Tardif, S. V erschoyle, R. D., 493 Shen, S.-C., 1417 Tatebe, _ Verschueren, H., 1313 Shepard, H. M., 179 Taylor, Vieytes, M. Ri, 27 Shin, V. Y., 1439 Taylor, SM. Vilarifio, N., 82 Visser, C., 137 Whelan, C. J., 733 Vitale, G., 1409 WY ientyes, F., 1063 Vohringer, C., 1259 Wiesinger, H., 893 ‘ollmar, A. M., 587 Wiesmann, U. N., Voorn, D. A., 1401 Wikberg, J. E Will, Y., 595 Vagner, C., 1119 Williams, W. M., 245, 925 Wakusawa, S., 1339 Williamson, R. A., Vang, J.-L., 153 Winski, S. L., 1511 ‘ang, J.-W., 1537 Witkamp, R. F., 1137 ‘ard, S. A., 409 Witt, T. L., 665 ‘ardman, P., 12‘ Woodruff, T. M., 1571 arner, F. J., 55 Woods, J. A., 1217 Varren, D. J., 70 Wu, S.-N., 877 ‘atters,D . J., 1093 Wurch, T., 1 Ui 79 Wei, E. Q., 1 Wellman, M., 60 Xu, K., 165 Welsh, N., 1561] Zhu, ¢ Werner, B., 1033 Yajima, S., 11] Zittoun, J., Wesselborg, S., 119 Yamada, H 5 Ziindorf, G., 125 Westwoo, R., 227 Yamamoto, T., 65 Zunino, F., SUBJECT INDEX Acyl-CoA thioesters Amino acids hepatocyte nuclear factor-4a suppression by, 1057 essential, protein-calorie malnutrition and, 15 Acyl-CoA:cholesterol acyltransferase A minoethylisothiourea norephinephrine-induced contraction in femoral arteries F 12511 effects on adrenocortical cells, 387 inhibition, F 12 and, 109 511 effects, 97 Adenosine Aminoguanidine iS agonist at adenosine receptors, 443 amidine structure for inhibition of nitric oxide biosyn- apoptosis induced by, adenosine receptors and uptake thesis and, 1581 role in, 417 1-Aminooxy-3-aminopropane Adenosine A, receptors colon cancer cell growth inhibition and, 199 immunolocalization in rat kidney, 237 Amphiphilic peptide PD81,723 effects on agonist/antagonist binding at, 137 mastoparan analogs interaction with neutrophil NADPH Adenosine A>, receptors oxidase and, 1063 antagonist radioligand for, 657 a sinensis Adenosine receptors proliferation in gastric epithelial cell line induced by, adenosine and inosine as agonists at, 443 mechanistic study, 1439 Angiogenesis Adipose tissue, white regulators and clinical applications of, peroxisome proliferation relation to stearoyl-CoA de Angiotensin AT, receptor saturase, 357 binding, receptor internalization and, Adrenal cells Angiotensin I] F 12511 effects on, 387 type | receptor, nonpeptide antagonists and, interaction Adrenalectomy model, 277 polyamine stress response and, 207 Angiotensin-converting enzyme a, ,-Adrenoceptot RXP407 potency and selectivity on, 835 coupling to G,-proteins, ligand response modulation Antagonists and, 1079 non-peptide, type | receptor angiotensin II and, interac- Afferent arteriole tion model, 277 adenosine A, receptor immunolocalization in rat kidney Anthracycline antibiotics and, 237 ugar moiety role in activity of, 933 AG879 Anticancer agents transcriptional regulation in drug metabolism, 215 5-fluoro 2’-deoxyuridine coupling to lactosaminated Airway smooth muscle poly-L-lysine and, 459 protein kinase stimulation by tumor necrosis factor Antifolate subtypes in, 749 suppression, folate cofactor pool augmentation in tumor Ajoene cells and, 857 cyclooxygenase 2 effects, 587 Anti-inflammatory drugs lcohol consumption petasin, 1041 chronic, G,, and epidermal growth factor receptor Antileukemic drugs signaling and, 1021 cytarabine-induced apoptosis, oxygen radicals and, 1 Alcoholism Antioxidants disulfiram aversion therapy, mechanisms of, apomorphine toxicity protection and, 73 Aldehyde dehydrogenase artemisinin neurotoxicity and, 409 mitochondrial, disulfiram adduct determination with, carvedilol, heart mitochondrial lipid peroxidation inhibition and, 15 AMA: see S-(5'-deoxy-5’-adenosyl)-methylthioethyl-hy- free structural di amage to proteins by free radicals and, droxylamine 1237 Amastigote interaction of enkephalins with oxyradicals, 1253 ribonuclease H as mediator of antisense phosphorothio- a-tocopherol quinone, glutathione effects on, 715 ate oligonucleotide lethality and, 467 Antisense phosphorothioate oligonucleotide Amine oxidase lethality, ribonuclease H as mediator of, 467 semicarbazide-sensitive, 2-bromoethylamine inhibition Antitumor agents angiogenesis antagonist development and, 253 of, 741 \ therosclerosis anthracycline untibiotic Ss, Sugar motety role In activity of, acyl-CoA cholesterol acyltransferase inhibition and, F 933 arsenic trioxide, multidrug-resistance protein l resistance 12511 effects, 97 low-density lipoprotein glycation and oxidation, calcium intagonist inhibition of, topotecan effects on restenosis, 119 CC-1065, cross-linking DNA in tumor cells, 67 5-diethylaminoethylamino-8-hydroxyimidazoacridinone, \trial natriuretic factor proteolytic activation of membrane-bound guanylate ictivation after DNA intercalation, 685 NB-506, inhibition of topoisomerase 1, 299 C lase ind, 9] 5 NB1Oi1, thymidylate synthase activation of, 179 Baicalein smooth muscle cells, bradykinin B, receptors in, 291 iNOS and cyclooxygenase-2 gene expression inhibition, A\P2 gene 1417 down-regulation in adipose tissue, 14 | B 2AICALIN A phidocolin iNOS and cyclooxygenase-2 gene expression inhibition, activation, DNA synthesis inhibition and, 191 1417 Apoptosis Bel-2 adenosine-induc ed, adenosine receptors and uptake role modification and role in antitumor therapy, 381 in, 417 Benodiazepine receptor cytarabine-induced, oxygen radicals and, 1033 permeability transition induction in cardiac mitochon- etoposide-induced, KN-62 effects, 49 dria and, 695 7B-hydroxycholesterol-exposed U937 and HepG2 cells, ©O°-Benzylguanine 1217 metabolism, O°-benzyl-8-oxoguanine debenzylation in cell, p38 mitogen-activated protein kinase role in, liver and, 721 1561 O°-Benzyl-8-oxoguanine peroxynitrite-induced, neonatal astrocytes, morphine debenzylation in liver, O°-benzylguanine metabolism protective effects, 779 and, 721 pharmacological cytoprotection and, 769 Bv erZenatT iDbrra te . phenethyl isothiocyanate cytotoxicity and, 165 pteeer oxisome opero lifeernaet ion ages relaeteie one to ste; aroy veOA r de Aquopentacyanoferrate saturase and, 357 from nitroprusside, NMDA receptor blockade LA ) 0) 24 Arabinosyl nucleoside slutamate release inhibition by sodium blockade mitochondrial thymidine kinase-2 inhibition and, 727 Arabinosylcytosine BIA glutamate release inhibition by sodium blockade and, resistance, fluoropyrimidine effects on, 39 Arachidonic acid 127 Bilirubin malaria pigment activity in, 999 degradation, cytochrome P450 1A2 role in, 843 phospholipase A, inhibitors effects on, 811 Biliverdin Arachidonyl trifluoromethylketone heme oxygenase and cyclo-oxygenase activities in phospholipase A, inhibitors and, 811 tral nervous system and, 437 Aroclor 1254 Bilobalide transcription factor gene expression and, 145 NO production in macrophages and endothelial cells, Arsenic trioxide 503 multidrug-resistance protein | resistance Binding site Artemisinin noncholinergic, nicotine binding to THP-1 cells and, glutathione role in neurotoxicity of, 409 733 Aspirin Bioflavonoid rutin gastrointestinal injury induced by, cyclooxygenase inhi- antioxidant and anti-inflammatory activity enhance- bition as cause of, 631 ment, 677 Asthma Biotechnology bronchial smooth muscle contraction, Gi3 protein in- enzyme kinetics implications in, 1049 volvement in, 921 Bistratene A protein kinase stimulation by tumor necrosis factor in protein kinase C-dependant signaling pathways stimula- airway smooth muscle and, 749 tion by, 1093 BIl eomycin ‘“amphor intioxidant inti-inflammatory activity enhance nicotinic acetylcholine receptor inhibition by, 787 vancer prevention ‘avage induced by, pyrrole triamide and, 351 polyunsaturated fatty acids, melatonin, ‘ancer therapy idation inhibition by, inthracycline antibiotics, sugar moiety role in activity of, 933 : Bone marrow irsenic trioxide, multidrug-resistance protein | resistance stromal cells, NF-KB expression after etoposide treat- to, 1387 ment, 1243 3cl-2 role in, 381 Bradykinin colon, hydroxylamine-containing inhibitors inflammatory pain induced by carrageenin and, 911 srowth, 199 B=r ady1 k]i ni. n B,) receptors guanidine compounds in, biochemical and clinical phar- . 1OTTIC smooth muscle cells, 291 macology, 1183 Brain indole-3-acetic acid oxidation to cytotoxic species and, olyamine stress response and, 129 cancel phenethyl isothiocyanate, glutathione metabolism role S-Tretinolc acid 11 fr kdown of retino in cytotoxicity, 165 receptors a/y ‘andesartan noenol lactone ingiotensin II type | receptor and non-peptide antago- lipase A ——ia 2-Bromoethylamine binding of, receptor internalization and, semicarbazide-sensitive inhibition ‘annabidiol 741 brain disposition alterations, 1357 AGL v7 -arbachol Z receptorisn , ,5-trisphosphate receptor isoform expression Broussochalcone A muscarinic receptor subtypes effects on thyroid hormone iNOS suppression in LPS-activated macrophages, 939 ul formation and, ‘arbamazepine glutamate release inhibition by sodium blockade, arbamylcholine on after DNA intercalation, 685 inositol 1,4,5-trisphosphate receptor isoform expression 5A rece} tor and, 327 ligand selectivity by mutation in, 11 5 71 ‘arbaryl vatteine CYPILAI1 expression, oxidative stress, and genotoxicity idenosine receptor blockade and, 443 alcitriol effects, 399 20-methyl group effects on vitamin D metabolism and, arbon monoxide heme oxygenase and cyclo-oxygenase activities in cen- 893 Calcium tral nervous system and, 437 intracellular, muscarinic receptor subtypes effects on ‘arcinogenesis thyroid hormone formation and, 337 ajoene inhibition of cyclooxygenase 2 by lipopolysaccha Calcium antagonist ride and, 587 low-density lipoprotein glycation and oxidation and, 373 ‘arrageenin Calcium channels inflammatory pain induced by, bradykinin mediation of, clozapine inhibition of, 1011 911 of lymphocytes, yessotoxin modulation of, 827 ‘ary edilol Calcium entry chenodeoxycholate induction of permeability transition yessotoxin inhibition of, 827 pore and, 1449 Calcium mobilization heart mitochondrial lipid peroxidation inhibition by, diadenosine tetraphosphate response to P2Y receptors 155 and, 623 Caspase activation cAMP: see Adenosine 3’,5'-cyclic monophosphate CYP inducibility by, 1293 cAMP synthesis Catecholamine secretion HR325 inhibition of, 227 camphor effects on, 787 Molt-4 T-cell invasion across fibroblast monolayers, CC-1065 cross-linking DNA in tumor cel 1313 , ' -C-cyano-2'-deoxy-1-B-bD-arabino-pentofuranosylcytosine CHO cells pharmacokinetics and pharmacodynamics of, 1497 angiotensin II type 1 receptor and non-peptide antago- ‘D4* lymphocytes nists interaction and, 277 HIV-1 expression in, K-opioid receptor suppression, 1145 holesterol ‘ell cycle lipid-lowering agents, F 12511 and, 97 genistein effects on, in nonneoplastic mammary cells, ‘hromaffin cells 979 camphor effects on catecholamine secretion in, 787 progression by melanoma cells, flavonoids effects on, clozapine inhibition of calcium channel and _n icotinic 205 acetylcholine receptor in, 1011 proteasome degradation role in toposiomerase Ila regu iprotibrate lation, 795 peroxisome proliferation relation to stearoyl-CoA de- ‘ell death saturase and, 357 pharmacological cytoprotection and, 769 ‘isplatin ‘ell growth platinum adducts in lung cancer cells and, 573 phospholipase A inhibitors effects on, 811 ‘lozapine ‘ell proliferation cyclosporine A induction of, in hepatocytes, 427 calcium ch| annel 1 and nicotinic acetyl1 ch1 oline receptor inhibition, 1011 ‘ellular respiration YNDAC: | see 2'-C-cyano-2'-deoxy-1-B-) b-arabino-pento HR325 inhibition of cAMP synthesis a ‘entral nervous system furanosylcytosine heme oxygenase and cyclo-oxygenase activities in, 437 oC] eramide heme oxygenase and cyclo-oxygenase ictivities in cen- elevation, glucosylceramide synthase inhibition and, in tral nervous system and, 437 neuroepithelioma cells, 851 ollecting ducts ‘hemopreventive agents adenosine A, receptor immunolocalization in rat kidney methylseleninic acid, mammary epithelial tumor growth and, 237 effects, 311 olon themotaxis cancer cells, hydroxylamine-containing inhibitors effects IL-8-induced neutrophil, ketoprofen inhibition of, 1429 mn growth, 199 ‘hemotherapy ‘olorectal cancer deoxycytidine kinase, DNA synthesis inhibition role in cell growth, hydroxylamine-containing inhibitors effects activation, 19] on, 199 enzyme kinetics implications in, 1049 MRP gene sensitivity to prooxidants in, 555 enzyme-catalyzed therapeutic agent, thymidylate syn- ongestive heart failure thase activation of, 179 carvedilol, lipid peroxidation inhibition and, 155 5-fluoro ’ 2'-deoxyuridine coupling to lactosaminated ‘oronary angioplasty poly-L-lysine and, 459 restenosis and, topotecan effects, 119 guanidine compounds in, biochemical and clinical phar- ‘yclic ADP-ribose nacology, 1183 inositol 1,4,5-trisphosphate binding and, 803 MRP gene and y-glutamylcysteine synthetase sensitivity "yclooxygenase-2 to prooxidants in colorectal cancer cell lines, 555 ajoene inhibition of, 587 P-glycoprotein overexpression and, 61 gene expression, wogonin, baicalin, and baicalein inhi- phenethyl isothiocyanate, glutathione metabolism role bition of, 1417 in cytotoxicity of, 165 stimulation by NO-derived species in chondrocytes, 965 Chiral inversion ibuprofen metabolism, acyl-CoA synthetase expression suppression, iNOS induction and, wogonin effects, 1195 ‘yclooxygenases and, 651 Chloroquine heme oxygenase and, in cortical astrocytes, 437 malaria pigment activity in arachidonic acid micelles and indomethacin, tumor cell proliferation and progression unilamellar vesicles, 999 effects, 565 with zidovudine and hydroxyurea, anti-HIV-1 effects, inhibition, NSAID-induced gastrointestinal injury and, 153] 631 Chlorpromazine ‘yclosporine A dipalmitoylphosphatidylserine surface area effects, 817 cell proliferation in hepatocytes and, 427