Table Of Content

AUTHOR INDEX Abrahem, Abrahem, 1123 Bowmer, C. J., 727 De Backer, J.-P., 927 Ahlstrom, Mikael, 1133 Boyd, M .R., 573 de Castro, Rogerio C., 1289 Ailhaud, Marie-Christine, 1521 Bracht, Adelar, 1187 de Koster, B. M., 369 Akagi, R., 871 Brand, M. D., 597 De Los Angeles, J., 517 Akhtar, R. A., 115 Brandis, Alexander, 1444 de Nigris, Filomena, 1477 Akimoto, M., 401 Bratt, J., 1007 De Nucci, Gilberto, 1289 Albrightson, C. R., 847 Braun, L., 801 de Vrueh, Remco L. A., 1407 Alcén, Soledad, 1077 Breittmayer, J.-P., 855 Defais, Martine, 1101 Allie, F., 167 Brown, K. L., 455 Delacauw, Anne, 1237 Allouche, S., 915 Buetler, T., 703 Deluca, H. F., 621 Alvarez, Alberto M., 1091 Bunde, Carolyn J. W., 1489 Demarquoy, Jean, 1351 Amano, Shigeru, 1539 Burchell, A., 801 DePierre, J. W., 377 Amato, Giaada, 1425 Burchell, B., 801 Desai, Sejal H., 1265 Anania, Vittorio, 1477 Burmester, G.-R., 597 Di Stefano, G., 301 Anderson, P., 753 Busi, C., 301 Dieter, M. Z., 65 Andersson, U., 821 Butters, T. D., 821 Diksic, M., 673 Andrés, David, 1091 Buttgereit, F., 597 Dilworth, F. J., 621 Andrews, G. K., 95 Dimova, Svetlana, 1467 Antunes, Edson, 1289 Camello, Pedro J., 1077 Doward, Sarah, 1403 Appelkvist, E.-L., 377 Camerino, A., 301 Downing, A. T., 563 Asao, Tetsuji, 1227 Cao, S., 953 Drukarch, Benjamin, 1023 Carcelen, R., 605 Asbrink, S., 1007 Dwek, R. A., 821 Cardoen, Sabine, 1237 Ashida, H., 741 Aussel, C., 855 Cardounel, A., 753 Eastham, Linda, 1265 Austin, C. A., 629 Carr, R., 629 Eaton, D. L., 703 Avallone, Rossella, 1387 Cascales, Maria, 1091 Eckle, T., 467 Ax, W., 293 Cassinelli, Giuliana, 1529 Ecosse, David, 1351 Cassinis, Marco, 1529 Elferink, J. G. R., 369 Certad, Gabriela, 1123 Elsenhans, B., 907 Baccanari, D. P., 953 Chang, C., 997 Emura, Tomohiro, 1227 Bachschmid, M., 153 Chang, J., 211 Eriksson, Staffan, 1573 Badger, T., 583 Chang, J.-Y., 497 Etiévant, C., 807 Baker, Glen, B., 1253 Chang, Thomas K. H., 1277 Bakhtiar, R.891 Charoenteeraboon, Juree, 1323 Fairlamb, A. H., 615 Bambagioni, Sabrina, 1365 Chattopadhyay, A., 419 Farkas, B., 937 Banaudha, Krishna K., 1315 Chauviére, G., 615 Feller, D. R., 517 Bandiera, Stelvio M., 1277 Cheah, Tat Beng, 1141 Ferey, V., 915 Bandyopadhyay, D., 419 Chen, H.-X., 497 Ferrali, Marco, 1365 Banhegyi, G., 801 Chen, Yen-Chou, 1445 Fertel, R. H., 517 Baraldi, Mario, 1387 Chen, Z., 329 Fierens, F. L. P., 927 Barnes, M. J., 321 Cheng, Y.-C., 497, 983 Fillmore, Bardley J., 1489 Barnes, S. J., 997 Chibout, S.-D., 267 Finch, R. A., 983 Barret, J.-M., 807 Childers, Steven R., 1395 Fiume, L., 301 Barrett, M. P., 615 Chilvers, E. R., 305 Flatmark, T., 123 Barry, C. E., Ill, 221 Choudhury, T .D., 419 Fornace, A. J., Jr., 43 Bastow, K. F., 497 Ciccoli, Lucia, 1365 Forth, W., 907 Behrends, S., 713 Cioffi, Catherine L., 1033 Foster, Keith, 1403 Bellward, Gail D., 1277 Clothier, B., 115 Fournel-Gigleux, S., 467 Bement, W .J., 445 Clothier, R. H., 563 Fowler, C. J., 647 Ben-Shachar, Dorit, 1613 Cogan, Uri, 1613 Francis, J. E., 115 Benedetti, A., 801 Comporti, Mario, 1365 Franconi, Flavia, 1477 Berkhout, T. A., 591 Constantin, Jorgete, 1187 Frappier, Frangois, 1053 Bhagwat, S. V., 573 Cooper, J. A. D., Jr., 605 Fraundorfer, P. F., 517 Biddy, M. C., 831 Cooper, Keith R., 1147 Fry, J. R., 563 Biessen, Erik A. L., 1407 Coquil, J.-F., 131 Fu, Q., 497 Bijsterbosch, Martin K., 1407 Crocenzi, F. A., 1022 Fujishima, T., 691 Blier, P., 673 Csala, M., 801 Fujita, H., 871 Bobadilla, M., 267 Cuccuru, Giuditta, 1529 Fujita, Tetsuro, 1211 Bock, Karl Walter, 467, 1444 Culbreth, R., 605 Fujiwara, T., 871 Bohmer, F. D., 35 Cummings, B. S., 531 Fukatsu, S., 195 Bomzon, Arich, 1613 Fukushima, Masakazu, 1227 Bonizzi, G., 7 Daiber, A., 153 Fung, Ho-Leung, 1593 Bontemps, Frangoise, 1237 Dalton, T. P., 65 Fung, Jacqueline, 1147 Booth, Brian P., 1593 Danks, M. K., 773 Furfine, Eric S., 1063 Boskovic, Goran, 1265 Datta, A .G., 419 Bours, V., 7 Davis, S. T., 953 Gaarde, William, 1033 Bowie, A., 13 Dawson, Marcia, 1265 Galland, Stéphane, 1351 1641 1642 Volume Contents, Author and Subject Index for Volume 59, 2000 Gambetta, Romolo A., 1529 Iba, Michael M., 1147 Kreth, Klaus-Peter, 1559 Garay, Michelle, 1033 Ibarrondo, J., 131 Kruczynski, A., 807 Garcia, Luis J., 1077 Igisu, Hideki, 1567 Kucera, G. L., 407 Garle, M. J., 563 Ikeda, T., 887 Kuchta, Robert D., 1045 Gazawi, Haifa, 1613 Imbert, T., 807 Kulshreshtha, Dinesh K., 1315 Geiger, J. D., 477 Imura, N., 401 Kumari, Ranjana, 1315 Georges, Béatrice, 1351 Ingelman-Sundberg, Magnus, 1425 Kunze, T., 973 Georges, Elias, 1123, 1245 Inoue, M., 557 Kurobe, M., 691 Gervasi, Pier Giovanni, 1425 Inoue, Y., 347 Geysen, J., 655 Inui, K., 195 Laakso, J., 441 Giglio, Jose R., 1289 Ishii, T., 681 Lafon, Corinne, 1101 Glauert, H. P., 427 Ishii-Watabe, Akiko, 1345 Lamberg-Allardt, Christel, 1133 Gohil, J., 591 Isoir, Muriel, 1351 Landucci, Elen C. T., 1289 Gonzalez, P., 591 Iwata, K., 887 Lanzi, Cinzia, 1529 Grand-Jean, Florence, 1351 Izumi, Futoshi, 1141 Lapatto, R., 441 Graumann, K., 177 Laping, N. J., 847 Gregus, Zoltan, 1375 Jaffer, M., 993 Larminat, Florence, 1101 Grenet, O., 267 Jaiswal, Anil K., 1433 Lash, L. H., 531 Grill, S. P., 983 Jan, C.-R., 393, 639, 947 Le Borgne, Francoise, 1351 Groot, r. E., 591 Janssens, S., 655 Ledyard, Thomas H., 1501 Groschner, K., 719 Jarvis, Michael F., 1173 Lee, Chunja, 1417 Guan, J., 497 Jassi, K. L., 563 Lee, K.-H., 497 Guggiari, M., 261 Jauzac, P., 915 Lee, M.-O., 485 Guo, X., 497 Jeffery, E. H., 445 Lee, R. E., 221 Gursoy, E., 753 Jeyapaul, Janet, 1433 Lee, Tony J.-F., 1445 Gylenhammar, H., 1007 Jiang, S., 485 Lee, Y.-S., 241, 329 Gyurasics, Agnes, 1375 Jiang, Y., 763 Lenhard, James M., 1063 Jiang, Z., 497 Levonen, A.-L., 441 Habib, Marie K., 1253 Johnson, P., 455 Li, G. D., 545 Hainaut, P., 25 Jones, G., 621 Li, R., 455 Han, J.-K., 241 Jungbauer, A., 177 Li, Y., 427 Han, S.-Y., 485 Liao, Duan-Fang, 1163 Hanada, Kentaro, 1211 Kador, P. F., 329 Lim, L. E., 831 Hanazawa, Shigemasa, 1539 Kahlon, S. S., 605 Lin, J.-H., 357 Hara, Koji, 1141 Kajiwara, Koji, 1141 Lin, J.-K., 357 Hara, S., 401 Kakubari, M., 681 Lindros, K. O., 583 Harris, A. L., 993 Kalimi, M., 753 Literati-Nagy P., 937 Hasbi, A., 915 Kamchonwongpaisan, Sumalee, 1323 Liu, M.-C., 983 Hashimoto, Fumie, 1203 Kano, I., 881 Ljubuncic, Predrag, 1613 Hashimoto, Y., 195 Kanoh, H., 763 Lo, Y.-L., 665 Haslett, C., 305 Karppanen, H., 441 Loadman, P. M., 831 Hawksworth, G. M., 783 Kashiba, M., 557 Longo, Vincenzo, 1425 Hayakawa, Takao, 1345 Katz, Sidney, 1163 Lopez, Carlos Henrique, 1187 Hayashi, Hidenori, 1203 Kawai, Masahiko, 1277 Louw, A., 167 Helnder, A., 385 Kawamura, M., 681 Luo, R.-H., 545 Heps, S., 973 Kawata, Yasuhiro, 1539 Lussert, B., 783 Herdewijn, P., 655 Kazuno, Hideki, 1227 Herrlich, P., 35 Keiger, C. J. H., 233 MacDonald, John R., 1217 Herzig, Maryanne C. S., 1217 Khan, S. A., 997 Macphee, C. H., 591 Hidaka, H., 347 Kim, Hyeon-Soo, 1109 Madhavan, Subhashree, 1315 Higdon, Arlene L., 1217 Kim, Ji-E., 1545 Maekawa, M., 839 Hill, B. T., 807 Kim, M.-J., 241 Maher, Catherine, 1395 Hilly, M., 131 Kim, S. J., 485 Maher, Timothy J., 1601 Himeon, S., 401 Kim, Sung Ouk, 1163 Maida, Ivana, 1477 Hirakawa, M., 871 Kimura, Y., 347 Maiti, A., 455 Hirano, Hideyasu, 1141 Klegeris, Andis, 1305 Makeshwari, Radha K., 1315 Ho, C.-1., 357 Kleinschnitz, Matthias, 1387 Makin, H. L. J., 621 Ho, T., 847 Knight, A., 563 Mandl, J., 801 Hochgraff, Edna, 1613 Kobayashi, Shu, 1211 Mani, Haresh, 1315 Hoet, Peter H. M., 1467 Koch, L., 293 Manoharan, Muthiah, 1407 Hoetelmans, Rob W. M., 1553 Kodama, E. N., 273 Marangoni, Sergio, 1289 Hoffmann, Ewa, 1509 Koh, Diana S. K., 1323 Martinez, J., 865 Hollander, M. C., 43 Kolehmainen, Petri, 1579 Masaki, K., 195 Hédég, J.-O., 385 Kondo, 7. 401 Maser, E., 293 Hu, Y., 753 Konno, K., 691 Massey, J. B., 187 Huang, J.-D., 665 Kostrubsky, V. E., 445 Matsumoto, K., 681 Huang, Z., 961 Kovar, Karl-Artur, 1559 Matsumura, F., 741 Huang, Z.-F., 187 Krensky, A. M., 317 Matsuoka, Masato, 1567 Volume Contents, Author and Subject Index for Volume 59, 2000 Mauger, J.-P., 131 Oinonen, T., 583 Riddick, David S., 1417 Mayer, B., 719 Okano, T., 691 Roberts, Kari, 1217 Mayeux, P. R., 203 Okuda, M., 195 Robertson, I. G. C., 161 Mazurkiewicz, Anna, 1045 Olson, B. A., 847 Robinson, S., 115 McCaffrey, R. P., 273 Ouzzine, M., 467 Rodriguez Garray, E. A., 1022 McGeer, Edith G., 1305 Ozaki, Ken, 1539 Roe, A. L., 65 McGeer, Patrick L., 1305 Ozono, K., 691 Roma, M. G., 1022 Mclvor, R. S., 141 Ronis, M., 583 McLay, J. S., 783 Padget, K., 629 Rose, W. C., 983 Medina, Jestis, 1459 Palmblad, J., 1007 Rossi, A. G., 305 Mehta, R. C., 517 Palmier, Christiane, 1117 Rossi, Viviana, 1365 Méplan, C., 25 Palumbo, Giuseppe, 1477 Rousseau, B., 615 Mervaala, E., 441 Pan, M.-H., 357 Roy, P., 961 Merville, M.-P., 7 Pan, Xing-Qing, 1123 Rump, Erik T., 1407 Metz, S. A., 545 Papouli, Efterpi, 1101 Rustum, Y. M., 953 Miksys, Sharon, 1509 Parent, Marise B., 1253 Miller, D. D., 517 Park, J. H., 485 Saison-Behmoaras, E., 655 Miller, K. J., 509 Park, Yangwon, 1147 Sakane, F., 763 Miller, R. A., 733 Parker, J. C., 531 Salazar-Bookaman, M. M., 517 Mistry, S., 783 Parkinson, F. E., 477 Salet, C., 261 Mitsuya, H., 273 Parks, J. M., 605 Salminen, Antero, 1579 Mizuguchi, Hiroyuki, 1345 Patterson, A. V., 993 Saluta, G. R., 407 Monia, Brett P., 1033 Paulik, Mark A., 1063 Salvetti, Alessandra, 1425 Moon, Jungae, 1109 Pauwels, Petrus J., 1117, 1521 Sampson, A. E., 221 Moorehead, R. A., 337 Paxton, J. W., 161 Sanchez Pozzi, E. J., 1022 Moores, K. E., 591 Pearson, A. D. J., 629 Santoro, M. G., 55 Moreno, G., 261 Pelassy, C., 855 Sanz, Nuria, 1091 Moreno, J. J., 865 Pelech, Steven L., 1163 Sartorelli, A. C., 283, 983 Morton, C. L., 773 Pellegrino, J. M., 1022 Sato, M., 681 Mottino, A. D., 1022 Penketh, P. G., 283 Satoh, K., 881 Mulder, Gerard J., 1553 Pensa, Tiziana, 1529 Satoh, 5. 839 Miinzel, Peter A., 1444 Perié, J., 615 Saunders, M. P., 993 Murakami, H., 887 Perrin, D., 807 Schafer, R., 791 Murayama, T., 839 Peters, T. J., 115 Schewe, T., 435 Murray, J., 305 Pfaff, U.-B., 249 Schofield, P. C., 161 Phillips, R. M., 831, 993 Scholz, H., 713 Nagai, F., 881 Picard, L., 131 Schreier, Peter, 1387 Nagy, S., 741 Piette, J., 7 Schutrups, Jan, 1553 Nakagawa, K., 691 Platt, F. M., 821 Schwab, Matthias, 1559 Nakamura, Eiichiro, 1141 Polastron, J., 915 Selley, Dana E., 1395 Napoli, Claudio, 1477 Polizzi, Donatella, 1529 Semenza, G. L., 47 Nardo, B., 301 Pols, H. A. P., 621 Sessler, J. L., 733 Nasini, Gianluca, 1529 Pompella, Alfonso, 1365 Seth, Pankaj, 1315 Naylor, M. A., 993 Porst, H., 713 Sharma, Shekhar C., 1315 Nebert, D. W., 65, 703 Porter, D. J. T., 953 Shedlofsky, Steven I., 1295 Nelson, R. W. Potter, P. M., 773 Sheen, Yhun Y., 1545 Nemery, Benoit, 1467 Pozo, Maria J., 1077 Sheffield, M., 605 Nemoto, K., 401 Prahl, J. M., 621 Sheikh, M. S., 43 Nephew, K. P., 997 Pratesi, Graziella, 1529 Shek, Pang N., 1155 Nero, Pamela, 1033 Préveral, S., 655 Shepel, N., 477 Neuhard, Jan, 1573 Puga, A., 997 Shertzer, H. G., 997 Newell, D. R., 321 Puia, Giulia, 1387 Shiau, S.-Y. L.,.357 Nicols, C. L., 591 Purkiss, John, 1403 Shyam, K., 283 Nigam, S., 435 Signorini, Cinzia, 1365 Niki, Etsuo, 1076 Rafatro, Herintsoa, 1053 Sinclair, C. J. D., 477 Nikulin, V. I., 517 Rahman, I., 305 Sinclair, J. F., 445 Niles, Richard M., 1265 Raja, K., 115 Sinclair, P. R., 445 Nill, K., 249 Ramanitrahasimbola, David, 1053 Singh, Anoop K., 1315 Nishijima, Masahiro, 1211 Ranney, D. F., 105 Singh, G., 337 Nishino, Kimihiro, 1076 Rasoanaivo, Philippe, 1053 Slayden, R. A., 221 Nocentini, S., 261 Ratsimamanga-Rakoto, Albert, 1053 Smith, A. G., 115 Noguchi, Noriko, 1076 Ratsimamanga-Urverg, Suzanne, 1053 Smith, J. A., 727 Nolan, J., 993 Rauly, Isabelle, 1521 Snawder, John A., 1295 Nomura, Y., 839 Ravindranath, V., 573 Sohlenius-Sternbeck, A.-K., 377 Reiser, G., 791 Sohn, Jeongwon, 1109 O'Neill, L. A. J., 13 Richard, M.-J., 25 Sola, B., 915 Odaka, Y., 871 Richardson, Frank C., 1045 Soldan, M., 293 Ohmori, E., 871 Richardson, Katherine A., 1045 Solis, W. A., 65 1644 Volume Contents, Author and Subject Index for Volume 59, 2000 Some, M., 385 Tortoreto, Monica, 1529 Watanabe, August M., 1501 Soomis, R., 983 Tosheva, Raina T., 1295 Waxman, D. J., 961 Spear, B. T., 427 Toyama, Marcos, 1289 Weiel, James E., 1063 Spector, T., 953 Toyohira, Yumiko, 1141 Welch, Mary, 1403 Stadheim, T. A., 407 Tseng, C.-J., 393, 639, 947 Werz, Oliver, 1591 Steenpass, A., 713 Tsuiki, K., 673 Whitaker, E. M., 727 Steiner, S., 267 Tyndale, Rachel F., 1509 White, J. R., 591 Steinhilber, Dieter, 1591 Wierdl, M., 773 Steinmeyer, Andreas, 1591 Uchida, Eriko, 1345 Wiesinger, Herbert, 1591 Stemmer, Paul M., 1501 Ueno, Susumu, 1141 Wiegell, T., 583 Stenstrom, A., 647 Uezono, Yasuhito, 1141 Wilairat, Prapon, 1323 Stephens, Trent D., 1489 Ullrich, V., 153 Williams, Michael, 1173 Steward, K., 783 Ulus, Ismail H., 1601 Wispriyono, Bambang, 1567 Utsunomiya, Kensuke, 1141 Wolf, Armin, 1459 Storz, tm l Stratford, I. J., 993 Wong, T. H., 305 Strugala, G. J., 907 Vahrmeijer, Alexander L., 1553 Wong, W. S. Fred, 1323 Struthers, A., 783 Valette, Annie, 1101 Wood, S. G., 445 Su, Changian, 1573 Van Aerschot, A., 655 Woynarowska, Barbara A., 1217 Sudo, T., 347 van Berkel, Theo J. C., 1407 Woynarowska, Jan M., 1217 Sugimoto, E., 471 van de Velde, Cornelis J. H., 1553 Wright, D., 445 Sugimoto, J., 681 van den Bemd, G.-J. C. M., 621 Wrighton, S. A., 445 Sugiyama, K., 329 Van Den Berghe, Georges, 1237 Wurch, Thierry, 1117, 1521 Sumegi, B., 937 Van Den Neste, Eric, 1237 Wurtman, Richard J., 1601 Suntres, Zacharias E., 1155 van Dierendonck, Jan Hein, 1553 Sutherland, M., 435 van Hille, B., 807 Xu, X., 509 Suuronen, Tina, 1579 van Leeuwen, J. P. T. M., 621 Xu, Yan-Jun, 1163 Suzuki, Norihiko, 1227 van Muiswinkel, Freek L., 1023 Suzuki, T., 871 van Veghel, Richard, 1407 Yamada, T., 871 Suzuki, Y., 401 van Vlierberghe, Ronald L. P., 1553 Yamada, Yuji, 1227 Svensson, S., 385 Vanderheyden, P. M. L., 927 Yamaguchi, M., 471 Swart, P., 167 Vasiliou, V., 703 Yamasaki, A., 871 Sweeney, C. L., 141 Vaskonen, T., 441 Yanagihara, Nobuyuki, 1141 Szabados, E., 937 Vasquez, K. M., 983 Yang, Ling-Ling, 1445 Szakacs, J. G., 445 Vattanaviboon, Phantip, 1323 Yang, Y., 65 Szirmai, R., 801 Vauquelin, G., 927 Yano, Shingo, 1227 Vendermeeren, M., 655 Yates, M. S., 727 Tabrizi-Fard, Mohammad A., 1593 Vezmar, Marko, 1245 Yu, Su-Jin, 1109 Tachibana, K., 347 Via, D. P., 187 Yusa, K., 273 Tada, Yukio, 1227 Vicentini, Geraldo Emilio, 1187 Yuthavong, Yongyuth, 1323 Taira, Shoji, 1203 Vohringer, C., 791 Takahashi, T., 871 Zanger, Ulrich M., 1559 Takayama, H., 691 Waarlo, Ingrid H. E., 1407 Zanoli, Paola, 1387 Tansik, R. L., 953 Wagner, George C., 1147 Zaragoza, Asuncién, 1091 Taylor, G. A., 321 Wakabayashi, I., 719 Zdzienicka, Malgorzata Z., 1101 Terland, O., 123 Walker, J. C., 233 Zhang, C., 203 Theil, E. C., 87 Walker, L. M., 203 Zheng, M., | Thomas, Paul E., 1147 Walsch, J. P., 763 Zhu, H., 997 Tiger, G., 647 Wang, H.-K., 497 Zhu, X.-K., 497 Tilby, M. J., 629 Wang, Jianghai, 1573 Zickert, A., 1007 Tochizawa, S., 347 Wang, K.-Y., 393 Ziyadeh, F. N., 847 Toga, K., 347 Ward, C., 305 Zou, M.-H., 153 Tohmo, K., 583 Warlick, C. A., 141 Zunino, Franco, 1529 SUBJECT INDEX A,-Adenosine receptor Anticancer agents nucleodie efflux stimulation and inhibition of adenosine lactosaminated poly-L-lysine coupling effects on liver kinase by, 477 micrometastases, 301 N-Acetylcysteine Antileukemic agents NF-«B inhibition by, 427 cordycepin, mechanism of action of, 273 Aclarubicin Antioxidant gene inhibitory effects on nitric oxide in vascular smooth redox-sensing transcription factors for regulation of ex- muscle cells, 719 pression of, | Acridone carboxamide Antioxidant response element DACA metabolism to, aldehyde oxidase and, 161 metallothionein expression regulation and, 95 Adenosine A, receptor Antioxidants renal, expression in renal failure, 727 UGTI1A6 induction in Caco-2 cells, 467 Adenosine efflux Antisense oligonucleotides stimulation by A,-adenosine receptor, 477 c-fos effects on cisplatin sensitivity and, 337 Adenovirus Antitumor agents transvascular drug delivery and, 105 4B-amino-4’-O-demethylepipodophyllotoxin and camp- Adipogenesis tothecin, 497 vitamin A, acid stimulation by indinavir and, 1063 chloroethylnitrosourea vs. 1,2-bis(sulfonyl)hydrazine, le- Adrenal medullar cells sion comparison, 283 leptin receptor characterization and functional role in, F 11782, topoisomerase I and II inhibition and, 807 bovine, 1141 triapine, 983 [Ah] gene battery Antixoidant activity oxidative stress and, 65 carvedilol, lipid peroxidation and, 1069 Aldehyde oxidase Antixoidant defense systems DACA metabolism and inhibition by, 161 cyclosporine A and, 1091 Aldose reductase Aorta noncovalent inhibitor complex, 329 vasclar relaxation of, calcitonin gene-related peptide- Amidohydrolase dependent, 1593 fatty acid, pharmacologic properties of, using palmi- Apigenin toylethanolamide as substrate, 647 pharmacologic profile of, 1387 Amino acid Apoptosis brain levels of, changes after phenelzine administration, Brcal-induced, Gadd45 mediation of, 43 1253 CD95-induced, phosphatidylserine exposure regulation 48-Amino-4’-O-demethylepipodophyllotoxin of, 855 biochemical, cytotoxic, and antitumor activity of, 497 cisplatin-induced nephrotoxicity and, 195 Amiphiphilic amines colon cancer, retinoic acid effects, 485 active transport in small intestines, anesthetics compar- Gadd45 role in, 43 ison study, 907 hydroxymethylacylfulvene, in tumor cells, 1217 Amlodipine hypersensitivity of mitomycin C and, 1101 catecholamine storage vesicles and, 123 hypoxia/reoxygenation-induced, inhibition by antisense Anesthetics oligonucleotide targeted to JNK1, 1033 local, active transport of amphiphilic amines in small [Ah] gene battery role in, 65 intestines, 907 neutrophil, nitric oxide donors and, 305 Angiogenesis NF-«B activation by IL-18 and, reactive oxygen species hypoxia-inducible factor | and, 47 role, 7 Angiotensin receptor antagonists okadaic acid induced, L-deprenyl protective effects, 1579 Chinese hamster ovary cells expression angiotensin II osteoclase, curcumin effects on, 1539 type | receptors and, 927 p53 tumor suppressor protein and, 25 Angiotensin II type 1 receptor 1-B-p-arabinofuranosylcytosine-induced, c-Jun N-termi- CHO cells expression, angiotensin receptor antagonists nal kinase/p38 stress signaling role in, 407 and, 927 1-B-p-Arabinofluranosylcytosine Annexin V apoptosis induced by, c-Jun N-terminal kinase/p38 stress phosphatidylserine effects on CD95-induced apoptosis signaling role in, 407 regulation and, 855 Arachidonic acid Antibiotic agents resveratrol, prostaglandin production and reactive oxy- granulysin, identification and description, 317 gen species effects, 865 Volume Contents, Author and Subject Index for Volume 59, 2000 Arachidonic acid metabolism Cadmium hepoxilin A; biological actions on neutrophils and, 435 cytotoxicity in fibroblasts lacking c-fos, 1569 Arginine vasopressin metallothionein expression regulation and, 95 stimulation of ribosomal protein S6 kinase by, in rat p53 pathway control and, 25 cardiomyocyte, 1163 Calcium Artemisinin selectivity of diacylglycerol inhibitors, 763 inactiviation by thalassemic erythrocytes, 1337 Calcium antagonist Asialoglycoprotein receptor catecholamine storage vesicles and, 123 lactosaminated poly-L-lysine coupling effects on liver Calcium release channel micrometastases, 301 membrane environment effects on ligand-binding affin- Asthma ity and, 131 immunopharmacology of, advances in, 1323 Ca*-mobilization Atrial natriuretic factor ketoconazole-induced, in MDCK cells, mechanisms of, cGMP stimulation by, inactivation in MR-106 cells, 947 1133 cAMP expression and secretion by renal proximal tubule, 783 transport in perfused liver, rat, 1187 Aziridine cAMP pathway corticosteroid-binding globulin effects, 167 protein-mediated pertussis toxin-resistant attenuation of G, coupling to, 1521 Bepredil Camptothecin Ca’-release and influx in Madin-Darby canine kidney cells and, 639 biochemical, cytotoxic, and antitumor activity of, 497 BGP-15 Cancer ischemia-reperfusion injury in heart effects, 937 hypoxia-inducible factor 1 and, 47 Bile acid redox signalling and transition metals role in p53 path- effects on B-adrenoceptors, fluidity, and lipid peroxida- way control and, 25 tion in cardiac membranes, 1613 Cancer cells Bile secretion daunorubicin resistance, carbonyl reduction effect, 293 salt, silymarin effects on, rat, 1015 Caprate Binding affinity sodium, sodium deoxycholate and, epirubicin transport inositol 1,4,5-trisphosphate receptor, 131 effects, in epithelial Caco-2 cells, 665 Biotransformation Capsaicin drug treatment of Parkinson’s disease and, 1023 dichlorofluorescin oxidation stimulation by, vanilloid bis-Pyridinium receptor involvement, 563 permeability transition in isolated mitochondria, 261 substance P release from dorsal root ganglion and, 1403 1,2-bis(sulfonyl)hydrazines Carbonyl reduction DNA lesions produced by, 283 daunorubicin resistance development in cancer cells and, Bone formation 293 daidzein stimulatory effects on osteoblastic MC3T3-E1 Cardiomyocytes cells and, 471 stimulation of ribosomal protein S6 kinase by lysophos- Brain phatidic acid and arginine vasopressin, 1163 amidohydrolase fatty acid, pharmacologic properties of, Ca*-release using palmitoylethanolamide as substrate, 647 influx and, by bepredil, in Madin-Darby canine kidney flerobuterol effects on serotonin synthesis, rat, 673 mitochondria, cytochrome P450 forms and monoxygen- cells and, 639 Carvedilol ase activity in, 573 N-Butyldeoxygalactonojirimycin antixodant activity against lipid peroxidation and, 1069 glycosphingolipid biosynthesis, comparison with N-bu- nitric oxide generation in phagocytes and superoxide ion tyldeoxynojirimycin, 821 production, 1007 Butylrylcholinesterase Catecholamine storage vesicles isolation and characterization of cDNA encoding, horse calcium antagonists effects on, 123 liver, 773 CC chemokine receptor 1 selective binding of chemokine CKB8 to, 591 Caco-2 cells CD44 sodium deoxycholate and sodium caprate effects on leukocyte-endothelial cell adhesion in inflammation epirubicin transport, 665 and, 455 UGT1A6 induction in, 467 Volume Contents, Author and Subject Index for Volume 59, 2000 1647 CD95 nephrotoxicity induced by, apoptosis role in, 195 apoptosis induced by, phosphatidylserine effects on, 855 Clavilactones Cell adhesion mechanisms of action and pharmacology of, 1529 leukocyte-endothelial cells, inflammation and, sulfation Clinical trials and CD44 role in, 455 medicinal herbs and, 211 Cell cycle control Clofibric acid [Ah] gene battery role in, 65 isoprenoid lipid synthesis changes, rat hepatocytes, 1203 Cell damage Colon cancer BGP-15 effects on ischemia-reperfusion injury in heart retinoic acid effects on growth and apoptosis in, retinoic and, 937 acid receptor B association with, 485 Cell growth Cordycepin Gadd45 role in, 43 antileukemic activity and mechanism of action of, 273 mildronate effects on, 1351 Corpus cavernosum Cell proliferation nitric oxide-sensitive guanylyl cyclase expression in, 713 NF-kB activation by IL-1 and, reactive oxygen species Corticosteroid-binding globulin role, 7 aziridine influence on, 167 Cell signaling Curcumin hepoxilin A; biological actions on neutrophils and, 435 effects on osteoclast apoptosis, 1539 Cell transport Cycle AMP mildronate effects on, 1351 cilostamide effects on nucleotide phosphodiesterase Cellular activities isozyme activity and, 347 redox regulation and, | Cyclooxygenase-2 C-fos cisplatin sensitivity and, 337 regulation by IL-1 and TNF-a, 187 Chemistry resveratrol, prostaglandin production and reactive oxy- combinatorial gen species effects, 865 antimycobacterial drug development and, 221 Cyclopentenone matrix-assisted laser desorption ionization mass spec- heat shock response and, 55 trometry and electrospray ionization and, 891 Cyclophosphamide Chemokine CKB8 N-dechloroethylaton of, cytochrome P450 3A4 role in, selective binding to CC chemokine receptor 1, 591 961 Chemotaxis Cyclospine A hepoxilin A; biological actions on neutrophils and, 435 proliferation of pulmonary artery smooth muscle cells, neutrophil, IL-8-activated, inhibition by thapsigargin, verapamil and octreotide effects, 1459 369 Cyclosporine A Chemotherapy antioxidant defence systems and, 1091 c-fos effects on cisplatin sensitivity and, 337 vitamin D activation pathway effects, 267 liver micrometastases, lactosaminated poly-L-lysine cou- Cytochrome c reductase pling effects, 301 indolequinone EO9 sensitivity in tumor cells, 993 megazol, uptake by African trypanosomes, 615 Cytochrome P450 methotrexate, dihydrofolate reductase inhibition and, depression by staphylococcal enterotoxin B, 1295 141 forms and monooxygenase activity in brain mitochon- Chlormethiazole dria, 573 effects on cytochrome P450 of rat nasal mucosa, 1425 oxidative metabolism of Ecstasy and, 1559 2-Chloroadenine starvation and chlormethiazole effects on rat nasal mu- metabolism and cytotoxic effects of, 1237 cosa, 1425 Chloroethylnitrosoureas trichloroethylene metabolism and cytotoxicity and, 531 DNA lesions produced by, 283 Cytochrome P450 1A Cilostamide gestatisonal and lactational exposure of 2,3,7,8-tetra- nucleotide phosphodiesterase isozyme activity and, 347 Ciprofibrate chlorodibenzo-p-dioxin effects on, rats, 1147 NF-«B activation in hepatoma cells, 427 Cytochrome P450 3A2 Cirrhosis growth hormone regulation and developmental expres- thioacetamide-induced, collagen fiber decrease in liver sion of, 1277 by hepatocyte growth factor after, 681 Cytochrome P450 3A4 Cisplatin role in N-dechloroethylation of cyclophosphamide and c-fos influence on sensitivity of, 337 ifosfamide, 961 Volume Contents, Author and Subject Index for Volume 59, 2000 Cytochrome P450 3A9 Dietary supplements growth hormone regulation and developmental expres- medicinal herb classification and, 211 sion of, 1277 Dihydropyrimidine dehydrogenase Cytochrome P450 3A18 a-fluoro-B-alanine effects on antitumor activity and growth hormone regulation and developmental expres- toxicity of 5-fluorouracil, 953 sion of, 1277 N[(2'-Dimethylamino)ethyllacridine-4-carboxamide Cytochrome P450 2Bl1 aldehyde oxidase and, 161 nicotine-metabolizing, regional and cellular induction in Dipyridamole brain by nicotine treatment, 1509 drug-resistant dihydrofolate reductase and, 141 Cytochrome P450 2C7 Doxorubicine growth hormone-regulated periportal expression in liver, resistance, quinoline reversal of, 1245 583 Drug delivery Cytochrome P450 2C11 biomimetic transport and, 105 gene expression, transcription suppression by 3-methyl- Drug development cholanthrene, 1417 antimycobacterial, genomics and combinatorial chemis- Cytotoxicity try in, 221 cadmium, in fibroblasts lacking c-fos, 1569 medicinal herbs and, 211 2-chloroadenine and, 1237 Drug interactions hydroxymethylacylfulvene, in tumor cells, 1217 DACA and, 161 paracetamol, in pneumocytes and alveolar macrophages, Drug metabolism 1467 iron regulatory protein and, 115 isolation and characterization of cDNA encoding a DACA: see N-[|(2'-Dimethylamino)ethyllacridine-4-car- butylrylcholinesterase, 773 boxamide Drug resistance Daidzein dihydrofolate reductase, methotrexate and, 141 stimulatory effects on osteoblastic MC3T3-E1 cells, 471 Drug uptake Daunorubicin megazol, uptake by African trypanosomes, 615 resistance development, in cancer cells, carbonyl reduc- DT-diaphorase tion effects, 293 RH1 pharmacologic properties, 831 Dehydroepiandrosterone Dyslipidemia anti-stress effects of, 753 vitamin A, acid stimulation by indinavir and, 1063 Deoxycholate sodium, sodium caprate and, epirubicin transport effects, in epithelial Caco-2 cells, 665 Ebselen 2'-Deoxyribonucleoside as peroxynitrite scavenger, 153 antitumor, thymidine phosphorylase inhibitors effects Ecstasy on, 1227 cytochromes P450 identification in oxidative metabo- L-Deprenyl lism of, 1559 protective effects against apoptosis by okadaic acid in Edema neuronal cells, 1579 inflammatory, piratoxin-! induction of, 1289 Dermatan sulfate Embryonic development transvascular drug delivery and, 105 Dexamethasone NF-«B and oxidative stress, 13 Endoplasmic reticulum lipopolysacchride-induced lung injury and, rats, 1155 Diabetes 8-glucuronidase latency in murine hepatocytes and, 801 Endothelium aldose reductase-nucleotide-inhibitor complex and, 329 Diacylglycerol vascular, transvascular drug delivery and, 105 selectivity of, 763 Energy metabolism Diasteroisomers lymphocyte, high-dose glucocorticoids and, 597 2-methyl-la,25-dihydroxyvitamin D, and 2-methyl-20- Eniluracil epi-la,25-dihydroxyvitamin D, effects, in leukemia a-fluoro-B-alanine effects on antitumor activity and cells, 691 toxicity of 5-fluorouracil, 953 Dichlorofluorescin oxidation Enterotoxin B capsaicin stimulation of, vanilloid receptor involvement, staphylococcal, cytochrome P450 depression by, 1295 563 Epirubicin Dietary Supplement Health and Education Act transport, sodium deoxycholate and sodium caprate ef- medicinal herbs and, 211 fects on, in epithelial Caco-2 cells, 665 Volume Contents, Author and Subject Index for Volume 59, 2000 Erectile dysfunction Genistein nitric oxide-sensitive guanylyl cyclase expression in cor- daidzein stimulatory effects on osteoblastic MC3T3-El pus cavernosum and, 713 cells and, 471 Erythrocytes Genomics nitric oxide effects of nitric oxide donors in, 557 Mycobacterium tuberculosis and, 221 Erythropoietin Genotoxic exposure oxidative damage effects by hydroxyl radical, 419 p53 tumor suppressor protein and, 25 Escherichia coli Glucocorticoid receptor thymidine kinase expression in, 1593 dehydroepiandrosterone anti-stress effects and, 753 17B-Estradiol Glucocorticoids daidzein stimulatory effects on osteoblastic MC3T3-E1 high-dose, lymphocyte energy metabolism and, 597 cells and, 471 Glucose Estrogen receptor-a intestinal absorption, metformin effects, in rat intestine, human, tamoxifen agonistic and synergistic activity and, 887 177 B-glucuronidase latency Ethanol murine hepatocytes and, 801 acetaminophen hepatotoxicity and, 445 y-Glutamylcysteine synthase serotonin metabolism and, interaction between, studies heavy subunit gene, antioxidant response element-medi- using ethannol and 4-methylpyrazole, 385 ated expression and induction of, 1433 Eukaryotic cells Glutathione redox regulation and, | depletion, cell death induced by, in CC531 colon cancer, Extracellular matrix genes 1552 hepatocyte growth factor effects on, in mesangial cells, phosphono analogs of, inhibition of glutathione trans- 847 ferase, metabolic stability, and uptake of, 973 role in biliary excretion of trimelarsan and melarsoprol, 1375 F 11782 Glutathione S-transferase topoisomerase | and II inhibition and, 807 drug treatment of Parkinson’s disease and, 1023 Ferritin Glutathione S-transferase a genetic variation of, oxidative stress modulation and, 115 trichloroethylene metabolism and cytotoxicity and, 531 Ferrritin Glycolysis iron-responsive elements and, 87 nitric oxide effects of nitric oxide donors on energy Flerobuterol metabolism in erythrocytes, 557 effects on serotonin synthesis in rat brain, 673 Glycosphingolipid biosynthesis a-fluoro-B-alanine N-butyldeoxygalactonojirimycin and, 821 antitumor activity and toxicity of 5-fluorouracil, 953 G proteins 2'-Fluoro-Methyl-dNTP mu opioid receptor binding relation to activation of, polymerization by polymerase a, y, and primase, 1045 1395 5-Fluorouracil 8-opioid subtypes in neuroblastoma cell line, molecular toxicity, a-fluoro-B-alanine effects on, 953 entities in, 915 Free radicals Granulysin p53 pathway and, 25 identification and description, 317 Growth hormone Gadd45 regulation by CYP3A2, 3A9, and 3A18, 1277 apoptosis and, 43 Growth hormone regulation G, cell cycle arrest cytochrome P450 2C7 and, 583 induction by panaxydol, 1109 Guanine nucleotide synthesis Gemfibrozil inhibition, effects on insulin secretion, 545 isoprenoid lipid synthesis changes, rat hepatocytes, 1203 Guanylyl cyclase Gene expression nitric oxide-sensitive, expression in corpus cavernosum, metallothionein, regulation by oxidative stress and metal 713 ions, 95 NF-«B activation by IL-1B and, reactive oxygen species Halothane role, 7 hepatotoxicity induced by, hemin pretreatment effects, Gene transcription 871 aclarubicin inhibitory effects on nitric oxide in vascular Ha-ras smooth muscle cells, 719 hexitol nucleic acids biologic activity and, 655 Volume Contents, Author and Subject Index for Volume 59, 2000 Heart perfusion Immunopharmacology BGP-15 effects on ischemia-reperfusion injury in heart asthma, advances in, 1323 and, 937 Immunoprecipitation Heat shock protein inositol 1,4,5-trisphosphate receptor ligand-binding af- heat shock response and, 55 finity and, 131 Heat shock response Immunosuppression heat shock factors and, 55 cyclosporine A effects on vitamin D activation pathway Hemin and, 267 halothane-induced hepatotoxicity effects, 871 Indinavir Hepatocyte growth factor vitamin A, acid stimulation by, 1063 collagen fiber decrease in liver by, after thioacetamide- Indolequinone EO9 induced cirrhosis, 681 tumor cells sensitivity, cytochrome c reductase role in, Hepatocyte growth factor 993 extracellular matrix genes effects, in mesangial cells, 847 Inflammation Hepatocytes heat shock factors and, 55 murine, B-glucuronidase latency in, 801 NF-kB activation by IL-1 and, reactive oxygen species Hepatotoxicity role, 7 acetaminophen, ethanol and isopentanol effects on, 445 Injury halothane-induced, hemin pretreatment effects, 871 heat shock factors and, 55 Hepoxilin A, Inositol 1,4,5-trisphosphate receptor biologic actions on neutrophils, 435 membrane environment effects on ligand-binding affin- Heptahelical receptors purinergic and pyrimidinergic receptors and, 1173 ity of, 131 Herb Insulin secretion ) medicinal, classification as drug vs. dietary supplement, guanine nucleotide synthesis inhibition and, 545 211 Interferon-y Hexitol nucleic acids anterior, inducible nitric oxide synthase in P11 cells, 509 biologic activity at Ha-ras and ICAM-1 mRNA, 655 Interleukin-18 Hinesol cyclooxygenase-2 regulation by, 187 HK -ATPase inhibition by, 881 NF-kB activation by, reactive oxygen species role, 7 HK -ATPase Interleukin-8 inhibition by hinesol, 881 neutrophil chemotaxis, thapsigargin inhibition of, 369 Hydrazone production, attenuation by NF-KB, using decoy oligonu- erythrocytes protection against oxidative damage by, cleotides, 605 1365 Intestine Hydrogen peroxide metformin effects on glucose intestinal absorption, rat, resveratrol, prostaglandin production and reactive oxy- 887 gen species effects, 865 Iron Hydroxymethylacylfulvene mRNA targeting for regulation of, 87 cytotoxicity and apoptosis induction in tumor cells, 1217 Iron regulatory protein 5-hydroxytryptamine genetic variation of, oxidative stress modulation and, 115 ethanol and serotonin metabolism and, 385 Iron-responsive elements Hypertension ferritin regulation and, 87 pulmonary, hypoxia-inducible factor 1 and, 47 lron status renal glutathione synthesis down-regulation by nitric basal, genetic variation of, oxidative stress modulation oxide synthesis and, 441 and, 115 Hypoxia-inducible factor 1 Ischemia expression of, 47 hypoxia-inducible factor 1 and, 47 Ibuprofen Ischemia-reperfusion injury amidohydrolase pharmacologic properties, using palmi- heart, BGP-15 effects on, 937 toylethanolamide as substrate, 647 picroliv preventive effects, 1315 Ifosfamide Isopentanol N-dechloroethylaton of, cytochrome P450 3A4 role in, acetaminophen hepatotoxicity and, 445 961 Isoproterenol Immobilization stress plrotein dephosphorylation in myocytes after withdrawal dehydroepiandrosterone effects, 753 of, 1501