Table Of Content

AUTHOR INDEX Aarbakke, J., 1072 Bommelaer, G., 247 Daasvatn, K. O., 1113 Aasmoe, L., 1072 Bonizzi, G., 713 Dalton, W. S., 1037 Abbott, J., 1305 Bonnet, R., 511 Damian, Z., 753 Abou-Donia, M. B., 1245 Bono, F., 603 Day, B. W., 97 Aggarwal, B. B., 763 Bordet, J. C., 631 Day, R. O., 837 Aguilera, J., 111 Bostick-Bruton, F., 347 de Castro, I. N., 1341 Ahmed, N., 387 Bours, V., 713 De Cesare, M., 1133 Allen, R. A., 1375 Boven, E., 673 de la Puetra, R., 445 Altbach, M. I., 309 Boyd, D. L., 1059 De Marte, J., 753 Anderson, A., 1073 Bravo, C., 743 de Mol, N. J., 503 Andrews, G. K., 1031 Brodsky, J. L., 877 de Sousa, G., 255 Animati, F., 1133 Brouwer, M., 397 Dedon, P. C., 531 Annen, A.-S., 639 Brown, R. A., 1085 Dehkordi, L. S., 1305 Antila, S., 1407 Browne, G. S., 837 Delarue, F., 657 Arcamone, F., 1133 Brzezinski, M. R., 811 Delescluse, C., 255 Arslan, G., 65 Busi, C., 793 Demple, B., 531 Arthur, G., 1153 Dennis, M. F., 375 Ashford, M. L. J., 491 DePierre, J. W., 1199 Candeias, L. P., 375 Asins, G., 1011 Derenzini, M., 793 Capranico, G., 1133 Asker, D. S., 1311 Di Stefano, G., 793 Carloni, C., 899 Avril, C., 603 Diab, N., 433 Caro, M. C., 1125 Ayala, G., 743 Discafani, C. M., 917 Carraway, R. E., 1391 Domage, G., 433 Carroll, M. L., 917 Dominguez, Z., 1021 Babin, E. A., 1003 Carroll, S. F., 225 Dooley, T. P., 663 Bacchi, C. J., 89 Caruso, J. A., 1253 Draude, G., 383 Backer, R. D., 685 Caserini, C., 1133 Dray, F., 433 Bae, Y. S., 1153 Cassady, J. M., 1141 Drewe, J., 833, 1147 Baggett, B., 309 Castranova, V., 989 Du, J., 365 Bagheri-Yarmand, R. B., 1399 Catalioto, R.-M., 899 Dubois, M., 1021 Bakalara, N., 549 Cenas, N., 549 Duvillard, P., 951 Baker, S. S., 685 Centemeri, C., 263 Balachandran, R., 97 Chakrabarti, A., 987 Eisenberg, D., 225 Barber, A. M., 801 Chan, F. Y., 1265 Eizirik, D. L., 1159 Bartley, C., 639 Chan, P. K., 1265 Elayadi, A. N., 83 Basnet, P., 1431 Chan, T. H., 753 El-Fakahany, E. E., 171 Bates, T. E., 1311 Chan, W.-L., 927 Elias, D., 951 Batist, G., 1253 Chang, C.-R., 143 Elkahwaji, J., 951 Bayard, F., 657 Change, I.-M., 705 Ellis, B. A., 837 Beamer, L., 225 Chaubet, F., 1399 Ellis, J., 181 Beaune, P., 951 Chaudry, M. A., 531 Enyedi, P., 209 Bechoua, S., 1021 Chauvet, M.-T., 611 Erb, C., 681 Beglinger, C., 1147 Chauviére, G., 549 Eriksson, S., 397 Belehradek, J., Jr., 45 Chen, H., 811 Escudier, B., 951 Bellamy, W., 1037 Chen, L.-S., 1297 Essayan, D. M., 973 Berge, R. K., 1011 Chen, M.-C., 1159 Ettorre, A., 1133 Bergelson, J. M., 975 Cheng, Y.-C., 1351 Eu, J. P., 1079 Berggren, M. M., 187 Chiappetta, C., 597 Bergman, A. M., 397 Christopoulos, A., 171 Fabian, I., 823 Bergstrand, A., 1199 Christou, M., 619 Faessel, H. M., 567 Berridge, M. V., 387 Ciceri, P., 263 Fan, W., 1215 Berson, A., 951 Cipollone, A., 1133 Fariss, M. W., 1223 Berthet, F., 199 Clapham, P. R., 451 Faye, J.-C., 657 Best, L., 583 Cnubben, N. H. P., 1383 Fermandjian, S., 1399 Bettache, N., 549 Cohen, L. H., 365 Fernandez-Salguero, P., 1407 Bhat, P. V., 195 Coli, S., 263 Ferry, k. V., 861 Bhujwalla, Z. M., 309 Corvol, P., 611 Fink, D., 861 Bigioni, M., 1133 Costa, L. G., 721 Finnman, U.-B., 155 Bittel, D., 1031 Cotreau, M. M., 1227 Fischer, M. J. E., 503 Bittman, R., 1153 Coy, D. H., 1159 Fiume, L., 793 Bittoun, P., 1399 Crépin, M., 1399 Florio, C., 355 Blankenship, J., 1095 Crichton, R. R., 907 Floyd, M. B., Jr., 917 Bloom, J. W., 1003 Criscuoli, M., 899 Folkes, L. K., 375 Bock, K. W., 653 Croset, M., 631 Fontaine, F., 255 Boelaert, J. R., 907 Cucchi, P., 899 Frank, H., 681 Bohn, M. C., 135 Culler, M., 1159 Frausin, F., 355 Bohnensack, R., 1191 Curto, E. V., 663 Fredholm, B. B., 65 1461 1462 Volume Contents, Author and Subject Index for Volume 57, 1999 Fricker, G., 833, 1147 Herbert, J.-M., 603 Kitahara, J., 545 Fries, D., 1095 Hermersdorfer, H., 663 Kitahara, S., 955 Fu, L., 1351 Hibino, Y., 1415 Kitchen, D., 917 Fukui, Y., 219 Hider, R. C., 559, 1031, 1305 Klein, J., 681 Fuxe, K., 155 Hiramatsu, M., 1321 Kletter, Y., 823 Hirano, K., 1105 Ko, K. M., 77 Gad. Y..7... 763 Hiraoka, Y., 1415 Kobayashi, S., 935 Gaion, R. M., 355 Ho. Y.-S., 143 Koeman, J. H., 1383 Gandley, R., 989 Hollander, I. J., 917 Kojo, S., 1361 Garcia Mace, J. L., 433 Holmsen, H., 1113 Kommineni, C., 989 Garras, A., 1011 Honma, Y., 521 Komori, S., 955 Gasdaska, J. R., 187 Hou, X., 1159 Koop, D. R., 941 Gewirtz, D. A., 727 Houba, P. H. J., 673 Koppelman, M. H. G. M., 889 Gibbons, W. A., 1311 Hough, L. B., 1059 Koskela, S., 1407 Gi, ©., iii Hoult, J. R. S., 445 Krauth-Siegel, R. L., 549 Gillies, R. J., 309, 1037, 1047 Howell, S. B., 861 Kravstov, V., 823 Giolitti, A., 899 Hrboticky, N., 383 Kudo, M., 1311 Girard, P., 199 Huisman, H., 889 Kudo, N., 869 Giraud, M.-N., 247 Hukkanen, J., 1407 Kuipers, M. E., 889 Giroud, J.-P., 163 Husain, Z., 917 Kull, B., 65 Glaser, K. B., 291 Huwyler, J., 1147 Kusashio, E., 1415 Glatt, H., 663 Hyder, S. M., 597 Kwong, C., 663 Glover, V., 913 Iguchi, K., 1105 Goldberg, B., 89 Labbe, G., 951 Ikeda, K., 1361 Goldberg, Y., 321 Lagarde, M., 631, 1021 Ikegwuonu, F. I., 619 Goldstein, J. A., 1297 Laman, J. D., 889 Imura, N., 545 Goncalves, A., 1021 LeBlanc, D. A., 1233 Inserte, J., 111 Gonzalez, F., 1407 Lee, E.-Y., 579 Ishida, R., 1105 Goodwin, B. L., 913 Lee, H.-M., 143 Goparaju, S. K., 417 Leenders, R. G. G., 673 Jabs, T., 231 Gorbunov, N. V., 989 Legssyer, R., 907 Jang, D.-S., 705 Gorrell, T. E., 89 Lemmer, B., 539 Janjic, D., 639 Goshima, K., 955 Leoncini, G., 785 Janssen, L. H. M., 503 Grant, S. G., 97 Lesca, P., 255 Jarman, M., 801 Greco, W. R., 567 Lettéron, P., 951 Jean-Claude, B. J., 753 Greenberger, L. M., 917 Leung, L. W., 1153 Jefcoate, C. R., 619 Greenblatt, D. J., 1227 LeVan, T. D., 1003 Jiménez, E., 1125 Gregory, R., 1059 Leyland-Jones, B., 753 Johnson, B. D., 917 Grilli, M., 1 Leyva, A., 397 Johnson, S. W., 861 Grimshaw, R. M., 801 Li, H., 313 Jongsma, A. P., 397 Grove, A. D., 653 Li, J., 291 Jorden, J. L., 1283 Gschaidmeier, H., 653 Li, Q., 347 Jozefonvicz, J., 1399 Guano, F., 1133 Li, Q.-H., 1297 Juchau, M. R., 811 Guechev, A., 407 Li, Q.-Y., 425 Guizzetti, M., 721 Kadota, S., 1431 Li, X.-B., 927 Guo, Y.-L., 425 Kagan, V. E., 989 Lichtenberger, L. M., 247 Gupta, R. P., 1245 Kajiwara, K., 1361 Ligeti, E., 1209 Gutierrez, V. R., 445 Kalir, H. H., 823 Lim, D.-M., 579 Gutmann, H., 833, 1147 Kameyama, T., 1321 Lin, J.-K., 143, 1367 Kamiuchi, S., 1415 Lin, W., 1153 Haar, E. T., 97 Kang, B.-S., 705 Lin, W. W., 1245 Haas, A. L., 1233 Kao, J. J., 313 Ling, Z., 1159 Habgood, M. D., 1305 Karczewski, J. M., 9, 27 Lin-Shiau, S.-Y., 1367 Haisma, H. J., 673 Kato, R., 1297 Liu, S.-H., 1351 Hakkola, J., 1407 Kaur, G., 281 Liu, Z. D., 559, 1305 Hales, B. F., 1165 Kawanishi, S., 881 Lombardini, J. B., 1331 Hales, C. N., 491 Kawashima, Y., 869 London, R. E., 1233 Hamatake, M., 1105 Kedjouar, B., 657 Lorenz, R. L., 383 Hamilton, T. C., 861 Keenan, C. E., 39 Lorenzen, A., 65 Handley, M. K., 1059 Kelner, M. J., 83 Losiewicz, M. D., 281 Hardcastle, I. R., 801 Kenney, S., 1283 Loves, W. J. P., 407 Hase, K., 1431 Kenyon, S. H., 1311 Ln, 8. L., $99 Hashimoto, K., 955 Khalighi, M., 811 Lundgren, B., 1199 He, X.-H., 927 Khodr, H. H., 1305 Lynch, R. M., 1037 Hearing, V. J., Jr., 663 Kim, D.-K., 579 Hegardt, F. G., 1011 Kim, Y., 705 Macdonald, J. M., 1233 Henry, Y., 199 Kishi, T., 955 Madsen, L., 1011 Herault, J.-P., 603 Kishida, E., 1361 Maechler, P., 639 Volume Contents, Author and Subject Index for Volume 57, 1999 1463 Maggi, C. A., 899 Nicolaou, A., 1311 Renzetti, A. R., 899 Mahrour, N., 45 Nicosia, S., 263 Rinken, A., 155 Majee, S., 987 Nilakantan, R., 917 Ritter, J. K., 653 Makishima, M., 521 Nilsson, C., 65 Rivera, M. I., 1283 Malo, M. S., 917 Nishitani, Y., 219 Rob, A., 365 Maloney, J. A., 425 Noordhoek, J., 9, 27 Roberts, E., 329 Mangin, J. F., 187 Nutley, B. P., 801 Robin, M. A., 951 Manna, S. K., 763 Roch-Arveiller, M., 163 Manzini, S., 1133 Oesch, F., 653, 681 Rodriques, A. D., 465 Marsigliante, S., 1125 Ohya, T., 869 Rojas, B., 1037 Martinez, G. M., 1037 Ojimba, J., 989 Romero, J. J., 247 Martinez-Lavin, M., 743 Okamoto, T., 955 Rommelspacher, H., 511 Martinez-Zaguilan, R., 1037, 1047 Olianas, M. C., 649 Rotondaro, L., 899 Masuzawa, Y., 1361 Onali, P., 649 Rougier, P., 951 Matsumoto, H., 219 Ong, C.-N., 273 Rowlands, M. G., 801 MattioliA,. , 793 Orlowski, S., 45 Russo-Marie, F., 433 May, J. M., 1275 Overhand, M., 365 Rustum, Y. M., 567 May, M. K., 917 Owens, R. J., 1375 Ryu, S. Y., 705 McConnell, E. J., 39 Owman, C., 65 McGrouther, D. A., 1085 Ozolins, T. R. S., 1165 Safari, G., 163 McLaughlin, M. K., 989 Sahu, A., 1439 Paik, Y.-K., 579 McMorris, T. C., 83 Saito, I., 881 Pangburn, M. K., 1439 Medina, M. A., 1341 Salvatore, C., 1133 Papadopoulou, L. C., 481 Medvedev, A. E., 913 Samaha, H., 195 Paulussen, J. J. C., 503 Meijer, D. K., 889 Sanchez-Jiménez, F., 1341 Pawlowski, G. P., 1059 Meissner, G., 1079 Sandler, M., 913 Pease, L., 291 Memo, M., 1 Santis, C., 663 Pelkonen, O., 1407 Mendiratta, S., 1275 Saranen, A., 1407 Pelliccioni, P., 111 Merriman, M. W., 1375 Sato, T., 935 Périé, J., 549 Merville, M.-P., 713 Sausville, E. A., 281, 1283 Perloff, M. D., 1227 Mésange, F., 657 Schaeffer, P., 603 Perry, M. J., 1375 Michaud, A., 611 Scheeren, J. W., 673 Pessayre, D., 951 Miltenburg, J. C., 503 Schliiter, T., 1191 Peters, G. J., 397, 407 Min, R., 705 Schnecko, A., 539 Peters, J. G. P., 9, 27 Minhas, H. S., 303 Schoonbroodt, S., 713 Pieterman, E., 365 Minnick, A. A., Jr., 917 Schroder, J.-M., 121 Piette, J., 713 Minowa, Y., 219 Schuit, F., 1159 Pinard, E., 199 Mir, L. M., 45 Schwabe, U., 65 Pinedo, H. M., 397, 407, 673 Mitchelson, F., 171 Seidel, A., 653, 681 Pipeleers, D. G., 1159 Mitra, S. P., 1391 Seidenberg, M., 181 Platt, K. L., 681 Mizuguchi, H., 869 Sekine, N., 639 Poddevin, B., 45 Mizuta, K., 955 Seko, Y., 545 Poirot, M., 657 Mocsai, A., 1209 Sercombe, R., 199 Polla, B. S., 1344 Mohan, M. K., 801 Serra, D., 1011 Pollenz, R. S., 1177 Monteagudo, E., 1133 Seylaz, J., 199 Postmus, P. E., 407 Montiel, M., 1125 Shaw, P.-C., 927 Potier, P., 199 Moreno-Sanchez, R., 743 Shen, H.-M., 273 Powis, G., 187 Morgan, D. W., 291 Shen, R., 917 Pratesi, G., 1133 Moriya, H., 935 Shibata, M., 1105 Prigent, A.-F., 1021 Moss, D. W., 1311 Shudo, K., 521 Pron, G., 45 Motta, C., 247 Shutenko, Z., 199 Proudfoot, A. E. I., 451 Mukhopadhyay, A., 763 Shvedova, A. A., 989 Puri, R. N., 851 Murai, M., 1321 Signorello, M. G., 785 Murata, M., 881 Ou, 2... 3275 Silveira, L. H., 743 Mustafa, A., 753 Quesada, A. R., 1341 Slocum, H. K., 567 Smid, K., 407 Naganuma, A., 545 Radin, N. S., 589 Smink, N., 1383 Najib, A., 111 Raess, B. U., 39 Smith, D., 1037 Namba, T., 1431 Raghunand, N., 309, 1037, 1047 Snapka, R. M., 1141 Nassberger, L., 1199 Raguenes-Nicol, C., 433 Solito, E., 433 Nebel, S., 861 Rahmanti, R., 255 Sorman, J. L., 171 Necela, B., 1177 Rao, R., 685 Sorri, M., 1407 Negre-Aminou, P., 365 Raschko, F. T., 653 Spiess, A. J., 89 Nelson, C., 837 Rattendi, D., 89 Stamler, J. S., 1079 Némoz, G., 1021 Raunio, H., 1407 Stancel, G. M., 597 Newsholme, P., 491 Raviv, Z., 823 Stawowy, P., 511 Nguyen, T., 837 Rawal, N., 1439 Steinhauer, M., 425 Nicholls-Grzemski, F. A., 1223 Reed, E., 347 Stinson, S. F., 1283 1464 Volume Contents, Author and Subject Index for Volume 57, 1999 Stoltz, C., 1073 Tyurin, V. A., 989 Watanabe, M., 935 Stratford, M. R. L., 375 Tyurina, Y. Y., 989 Waterfield, C. J., 1311 Streichenberger, G., 433 Weinfeld, M., 531 Stuhlmeier, K. M., 313 Uckun, F. M., 9 Wells, T. N. C., 451 Sufrin, J. R., 89 Ueda, M., 1297 Welsh, M. J., 97 Sugano, N., 1415 Ueda, N., 417 Williams, K. M., 837 Sun, N.-J., 1141 Usami, Y., 1105 Williamson, J. R., 425 Supino, R., 1133 Wilson, D. M., III, 531 Suzuki, T., 697 v. d. Berg, M., 889 Wissner, A., 917 Suzumura, K., 697 Valentijn, P. M., 365 Witenberg, B., 823 Szabadkai, G., 209 van Bladeren, P. J., 1383 Witte, K., 539 van Boom, J. H., 365 Wolheim, C. B., 639 Takahashi, A., 881 van den Doelen, A. A., 57 Woo, S. H., 1141 Takahashi, T., 955 van der Marel, G. A., 365 Woon, C.-W., 1159 Talas, G., 1085 van der Meulen-Muileman, I. J., 673 Wright, S. H., 1047 Tam, S.-C., 927 van Haperen, V. W. T. R., 397 Tanabe, E., 1361 van lersel, M. L. P. S., 1383 Xia, Z., 1199 Tanaka, K., 697 van Leeuwen, R. E. W., 365 Xiong, Q., 1431 Tanaka-Kagawa, T., 545 van Moorsel, C. J. A., 407 Xu, L., 1079 Taniguchi, K., 417 Van Schravendijk, C., 1159 Xu, Q.-F., 927 Tateishi, T., 935 van Sluis, R., 309 Taylor, C. W., 309 Varnai, P., 209 Yagi, T., 845 Taylor, J.E., 1159 Vasilescu, D. E., 753 Yalowich, J. C., 97 Tedford, C. E., 1059 Vasquez, C., 743 Yamaguchi, S., 935 Tenner, T. E., Jr., 1331 Veeneman, G. H., 57 Yamamoto, S., 417 Theophilidis, G., 481 Veerman, G., 397, 407 Yamamura, H. I., 1003 Theunissen, H. J. M., 57 Vermorken, J. B., 407 Yamazoe, Y., 1297 Thomopoulos, G. N., 481 Vertua, R., 355 Yang, C.-F., 273 Thornalley, P. J., 303, 583 Vink, P. M. F., 57 Yang, L.-J., 425 Timbell, J. A., 1311 Viodé, C., 549 Yasuhara, M., 697 Tinel, M., 951 Virador, V., 663 Yasumori, T., 1297 Tirmenstein, M. A., 1223 Vistica, D. T., 1283 Yates, S. L., 1059 Tissot, M., 163 von Moltke, L. L., 1227 Yen, R., 753 Tokumaru, S., 1361 Yim, T. K., 77 Tordk, M., 833, 1147 Waddick, K. G., 9 Yu, J., 83 Tosarello, D., 263 Wadsworth, T. L., 941 Tounekti, O., 45 Wagoner, M. J., 39 Toyoda, H., 545 Wang, B.-S., 1367 Zaman, G. J. R., 57 Treré, D., 793 Wang, Y.-F., 917 Zambre, Y., 1159 Trygankova, O., 425 Wang, Z., 1095 Zappitelli, S., 899 Tsang, B., 347 Ward, R. J., 907 Zhang, X., 1331 Tsiftsoglou, A. S., 481 Wardman, P., 375 Zuidam, N. J., 503 Tsuzuki, T., 1297 Wart, P. J., 889 Zunino, F., 1133 SUBJECT INDEX Abl, glucose transport regulation by IL-3 and oncogenes NF-«B/Rel protein role in signaling pathways in, 1 and, 387 3-Aminobenzamide, DNA damage in colon cancer cells ACE N-domain, structure-function studies of N-acetyl- and, 19 seryl-aspartyl-lysyl-proline and, 611 Aminoguanidine N-Acetyl-seryl-aspartyl-lysyl-proline, N-domain selectivity PTB mechanism of action and, 303 of angiotensin I-converting enzyme and, 611 time-dependent production of nitric oxide by hepato- Activator protein-1, B-lapachone suppression of, 763 cytes and, rats, 1223 Acylfulvene, metabolism in rat liver cytosol, 83 3-Aminopropylphosphonate, tumor pH in breast cancer Adenosine A, receptors, species differences in human and xenografts, MRS investigation of, 309 rat, 65 Amyotrophic lateral sclerosis, glial cell line-derived neuro- Adenosine 3’,5'-cyclic monophosphate (cAMP) trophic factor gene therapy and, 135 P, receptors influence on forskolin effects in PC12 cells, Analog II, breast cancer cell apoptosis and, 97 355 Angiotensin I-converting enzyme, N-domain selectivity of, receptors, human vs. rat, 65 structure-function studies assessment of, 611 Adenovirus, attachment and internalization, receptors me- Angiotensin II diating, 975 epidermal growth factor and, regulation of extracellular Adenylyl cyclase, prostaglandins role in inhibition of, 851 signal-regulated protein kinase and, effects on mito- Adrenal cortical oxygenation, dehydroepiandrosterone sul- genesis, 425 fate and, 329 receptor, internalization and signaling in rat hepatocytes, Adrenal glomerulosa cells, ruthenium red inhibition of, 1125 rats, 209 Anion channel, volume-sensitive, pancreatic B-cell func- B-Adrenergic agonist, neurotensin and, effects on cAMP tion studies and, 583 accumulation and DNA synthesis in prostate cancer, Anionic phospholipids, mithramycin membrane interac- 1391 tion with, 981 Adriamycin Anthracycline antitumor effects, mechanisms of action of, 727 antitumor effects, mechanisms of action of, 727 cardiomyopathy induced by, cytochrome c oxidase II disaccharides, sugar moiety role in pharmacologic activ- gene expression suppression and, 481 ity of, 1133 MCF-7 cells resistant to, Ah receptor loss in, 1253 prodrugs, daunorubicin-GA3 distribution and pharmaco- Affinity, glucose transport regulation by IL-3 and onco- kinetics in ovarian cancer xenografts, 673 genes and, 387 Antiallergic agents, oxatomide, influence on membrane Aging structures, 503 advanced glycation end products and, 303 Antibiotics dehydroepiandrosterone sulfate and, 329 antitumor, mithramycin membrane interaction with an- iron deprivation as therapy and, 1345 ionic phospholipid vesicles, 981 Ah receptor, loss in benzo[a]pyrene- and adriamycin- epithelial peptide, clinical studies of, 121 resistant MCF-7 cells, 1253 Anticancer agents, epidermal growth factor receptor inhi- Albumin, succinylated human serum, mechanism of anti- bition by CL-387,785, 917 HIV activity of, 889 Antidepressant drugs, apoptosis induced by, reactive oxy- Alcohol dehydrogenase, sex-dependent induction, rats, gen species generation in mitochondrial membrane 1067 potential during, 1199 Aldehyde dehydrogenase, liver cytosolic, retinoic acid syn- Antiestrogen binding site, cell cytotoxicity and, 657 thesis and, 195 Antihypertensive agents, SKP-450, biochemical basis for, Aldosterone, production in rat adrenal glomerulosa cells, 579 ruthenium red effects on, 209 Anti-inflammatory drugs, nonsteroidal: see Nonsteroidal Allometry, predicting blood ethanol elimination and, in anti-inflammatory drugs mammals, 219 Antimicrobial peptides, epithelial, clinical studies of, 121 Allosteric modulation, muscarinic receptors and, 171 Antineoplastic agents | Alloxan, insulin release modulation in INS-1 cells exposed gemcitabine resistance to cytosine arabinoside-resistant to, 639 leukemia cell lines, 397 All-trans-retinoic acid, prenatal biosynthesis inhibition by thiopene, toxicity in renal carcinoma cell lines, 1283 ethanol and lipid peroxidation reactions, 811 Antioxidants Alminoprofen, mechanisms of action of, 433 ebselen protective effects against cytotoxicity and DNA Alveolar macrophages, chloroquine administration effects damage in HepG, cells, 273 on oxidative responses by, 907 fluvastatin sodium protective effects on oxidative modi- Alzheimer’s disease fication of low-density lipoproteins and, 697 advanced glycation end products and, 303 virgin olive oil effects in leukocytes, 445 1466 Volume Contents, Author and Subject Index for Volume 57, 1999 Antitumor agents Bacterial infection, lipopolysaccharide-induced, BPI effects acylfulvene, metabolism in rat liver cytosol, 83 on, 225 adriamycin, cardiovascular toxicity of, 481 Bactericidal/permeability-increasing protein (BPI), lipopo- adriamycin and daunorubicin, mechanisms of action of, lysaccharide-induced inflammatory response effects, 727 225 Analog II, breast cancer cell apoptosis and, 97 Bax protein, intracellular localization of, subcellular frac- apoptosis induced by, thymosin B, levels in, 1105 tionation analysis of, 143 gemcitabine and etoposide, effects in non-small cell lung Bcl-2, paclitaxel-induced apoptosis and, 1215 and ovarian cancer, 407 Behavior regulation, Fyn kinase and, molecular mecha- limonene, protein prenylation inhibition by, 801 nisms, ethanol sensitivity and, 845 mithramycin, membrane interaction with anionic phos- Benzo[a]pyrene pholipid vesicles, 981 MCEF-7 cells resistant to, Ah receptor loss in, 1253 naphthoquinones effects in colon cancer cell lines, 27 mono- and diglucuronide formation from, by UDP- tetrazepinone, mechanism of action in ovarian cancer glucuronosyltransferase isoforms, 653 cell line, 753 Benzophenone, antiestrogen binding site and, 657 Apoptosis Benzylphenoxy ethanamine, antiestrogen molecules, an- antitumor agent-induced, thymosin B, levels in, 1105 tiestrogen binding site influence on modification of, breast cancer cell, A), effects, 97 657 chemically induced, of HL-60 cells, hydrogen peroxide Binding sites, mechanism of anti-HIV activity of succiny- and hydroxyl radical involvement in, 1361 lated human serum albumin and, 889 DMSO role in promoting, 39 Bleomycin, toxicity, mechanisms of, 45 intracellular localization of Bax protein and, 143 Blood platelets, chlorpromazine and glycerolipid metabo- B-lapachone suppression of, 763 lism, 1113 NF-«B/Rel protein in cancer treatment and, 9 Blood-brain barrier NF-«B/Rel proteins role in signaling pathways and, 1 permeability, hydroxypyridinones and, correlation be- NPM-translocation and, daunomycin effects on, 1265 tween structure of, 1305 oxidative stress-induced, ascorbic acid role in inhibition ritonavir and P-glycoprotein inhibition and, 1147 of, in leukemia cells, 823 BPI: see Bactericidal/permeability-increasing protein paclitaxel-induced, mechanisms of, 1215 Brain reactive oxygen intermediates as mediators of, 231 choline levels, N-methylnicotinamide influence on, 681 Aporphine alkaloids, topoisomerase II inhibition by, 1141 ischemia-reperfusion, quercetin influence on nitric oxide Ara-C, gemcitabine activity in resistance to, 397 level during, rats, 199 Arachidonic acid mRNA expression of neurofilament subunits in, diiso- N-ethylmaleimide-stimulated, release in platelets, 785 propyl phosphorofluoridate-treated hens, 1245 prostaglandin H synthase inhibition and 12-lipoxygenase striatum, dopamine receptor activation in, rats, 155 activity by, 631 Breast cancer, tumor pH in xenografts, MRS investigation 2-Arachidonoylglycerol, hydrolysis by brain enzymes, 417 of, 309 Arbutin, methyl gentisate evaluation as skin-lightening Bromodeoxyuridine, Aj,;-induced cell death and, 97 agent and, 663 Bronchial epithelial cells, glucocorticoid pharmacologic Arteriosclerosis characterization in, 1003 dehydroepiandrosterone sulfate and, 329 tert-Butyl hydroperoxide, hemoglobin and, oxidative stress lovastatin effects on oxidized low-density lipoprotein induced by, effects on vascular smooth muscle cells, receptor expression on vascular smooth muscle cells 989 and, 383 Aryl hydrocarbon receptor binding, primaquine effects, 255 Ca’~ channels, inward current in Xenopus oocyte and, 491 nuclear translocator, activation and repression domains (Ca*~-Mg’~ )-ATPase activity, calmodulin-stimulated, in- of, rainbow trout, 1177 hibition by DMSO, 39 2-Arylpropionic acids, B-oxidation and oxidative phos- Ca’~ release channel, ryanodine receptor regulation by phorylation inhibition by NSAIDs and, 837 reactive nitrogen species and, 1079 Ascorbic acid, oxidative stress-induced apoptosis and, in Caco-2 cells, naphthoquinone effects on, 27 leukemia cells, 823 Calcium Asialoglycoprotein receptor, expression in hepatocellular cytosolic, increase in platelets and macrophages, 263 carcinoma, DNA synthesis inhibitors toxicity and, 793 vascular endothelial cell activation by factor Xa and, 603 Aspirin, ubiquitin reaction with, NMR analysis, 1233 cAMP: see Adenosine 3’,5'-cyclic monophosphate Atrial natriuretic peptide receptors, isatin efficacy as antag- Cancer: see also specific types onists of, 913 histamine and polyamines involvement in, 1341 Volume Contents, Author and Subject Index for Volume 57, 1999 1467 [H]norharman binding to ethanol-inducible cyto- Choline, levels in brain, N-methylnicotinamide influence chrome P450 2E1 in liver and, 511 on, 681 platelet-derived growth factor receptor tyrosine kinase Cholinergic neuronal system, modulation by dynorphin A inhibition and, 57 (1-13), carbon monoxide-exposed mice, 1321 Cancer cells, p53, Bax protein expression in nuclear mem- Chrysene diphenols, mono- and diglucuronide formation brane and, 143 from, by UDP-glycuronosyltransferase isoforms, 653 Cancer therapy Cisplatin gemcitabine and etoposide, effects, non-small cell lung cellular sensitivity to, DNA mismatch repair and, 861 and ovarian cancer, 407 resistance to, excision repair cross complementation NF-«B/Rel proteins and, 9 group | role in, 347 Cannabinoid receptors, anandamide hydrolysis by brain Citalopram, apoptosis induced by, reactive oxygen species enzymes and, 417 generation in mitochondrial membrane potential dur- B-Carboline, [’/H]norharman binding to ethanol-inducible ing, 1199 cytochrome P450 2E1 in liver and, 511 c-Jun N-terminal kinase, B-lapachone suppression of, 763 Carbon monoxide, cholinergic neuronal system modulation CL-387,785, epidermal growth factor receptors inhibition by dynorphin A (1-13) and, mice, 1321 by, 917 Carboxyfluorescein leakage, mithramycin membrane inter- Cl” channels, inward current in Xenopus oocyte and, 491 action with anionic phospholipid vesicles, 981 Clomipramine, apoptosis induced by, reactive oxygen spe- Cardiomyopathy, adriamycin-induced, cytochrome c oxi- cies generation in mitochondrial membrane potential dase II] gene expression suppression and, 481 during, 1199 Cardioprotection, schisandrin role in, rats, 77 Clostridium tetani, sodium-dependent 5-HT inhibition and, Cardiovascular disease, platelet-derived growth factor re- in rat synaptosomes, 111 ceptor tyrosine kinase inhibition and, 57 Colon, cancer cells Carnitine palmitoyltransferase II, as control site for keto- DNA damage to by oxidative stress-inducing agents, 19 genesis, 1011 naphthoquinones effects on, 27 Catalase, overexpression of, HeLa cell sensitivity to cis- Copper, overexpression of, HeLa cell sensitivity to cis- platinum and, 545 platinum and, 545 C3b, activated, rosmarinic acid attachment to, comple- Coronary heart disease, virgin olive oil effects in leukocytes ment inhibition by, 1439 and, 445 B-Cell activation, pancreatic, trioses in study of, 583 Cosmeceutical, methyl gentisate evaluation as skin-light- Cell death, programmed, reactive oxygen intermediates as ening agent and, 663 mediators of, 231 Cyclic AMP, signaling systems, serotonin-induced secre- Cell growth, thioredoxin and, selenium effects on, rats, 187 tion of von Willebrand factor from umbilical vein Central nervous system dysfunction, in utero ethanol expo- endothelial cells via, 1191 sure and, 721 Cyclic nucleotide phosphodiesterase, inhibitors, immuno- Central nervous system infection, NF-«B/Rel protein role modulation and, 965 in signaling pathways in, | Cycloheximide, Aj-induced cell death and, 97 Chagas’ disease, enzymatic reduction studies of nitrohetero- Cyclooxygenase, alminoprofen mechanisms of action and, cycles and, 549 433 Chemokine receptors, HIV therapy, 451 CYP2A genes, expression in liver and extrahepatic tissues, Chemotherapy 1407 anticancer, asialoglycoprotein receptor expression in CYP2B2 gene, phenobarbital responsiveness of, 1073 hepatocellular carcinoma, DNA synthesis inhibitors Cytochrome c oxidase II gene expression, suppression, toxicity and, 793 adriamycin-induced cardiomyopathy and, 481 bleomycin internalization and toxicity, 45. Cytochrome P450 combination, MRS investigation of tumor pH in breast hepatic, decrease in after interleukin-2 immunotherapy, cancer xenografts and, 309 951 glucosphingolipid synthesis slowing and, 589 phenytoin role in wound healing and, 1085 Chimeric proteins, UH-AH 37 interaction with muscarinic reaction phenotyping of, 465 receptors and, 181 Cytochrome P450 3A, midazolam, triazolam, and dexa- Chloroquine, iron loading in liver and reticuloendothelial methasone metabolism in liver microsomes and, mice, system and oxidative response by alveolar macro- 1227 phages and, 907 Cytochrome P450 3A5 and 3A7, ethnic differences in Chlorpromazine, platelet glycerolipid metabolism and, expression frequency in hepatic samples, caucasian vs. 1113 Japanese subjects, 935 Cholesterol, reducing, biochemical properties of SKP-450 Cytochrome P450 1Bl1, regulation in fibroblast cells by in, 579 PKC, mice, 619 1468 Volume Contents, Author and Subject Index for Volume 57, 1999 Cytochrome P450 2E1, ethanol-inducible, (H]norharman 3-(4-Dimethylamino-benzylidenyl)-2-indolinone, platelet- binding to, 511 derived growth factor receptor inhibition and, 57 Cytosol, rat liver, acylfulvene metabolism in, 83 Diphenylmethane, antiestrogen binding site and, 657 Cytotoxic agents, cell death caused by, free-radical oxida- Dissociation kinetics, allosteric modulation in muscarinic tive DNA damage and, 531 receptors and, 171 Cytotoxicity DMBI: see 3-(4-Dimethylamino-benzylidenyl)-2-indolin- cell, antiestrogen binding site and, 657 one . horseradish peroxidase and indole acetic acid, electro- DMSO: see Dimethyl sulfoxide philic oxidation products involved in, 375 DNA binding hydrogen peroxide-induced, ebselen protective effects estrogen receptors interaction with estrogen response against, 273 elements and, 597 horseradish peroxidase and indole acetic acid cytotoxic- Daunomycin, apoptosis and NPM-translocation induced ity and, 375 by, 1265 DNA damage Daunorubicin, antitumor effects, mechanisms of action of, in colon carcinoma cells by oxidative stress-inducing 727 agents, 19 Daunorubicin-GA3, distribution and pharmacokinetics in ebselen protective effects against, 273 ovarian cancer xenografts, 673 free-radical oxidative, cell death by cytotoxic agents and, Defensins, epithelial peptide antibiotics and, 121 531 Dehydroepiandrosterone sulfate, steroid functionality and, DNA mismatch repair, cellular sensitivity to cisplatin and, 329 861 15-Deoxyspergualin, selectivity of, 877 Docosahexanoic acid, protective effects against hydrogen Dexamethasone peroxide-induced oxidative stress, 1021 metabolism in liver microsomes, cytochrome P450 3A Dopamine receptors, functional activation in rat striatum, expression and, mice, 1227 155 pharmacologic characterization in bronchial epithelial Drug metabolism cells, 1003 cytochrome P450 and, reaction phenotyping of, 465 Dextran thiopene, toxicity in renal carcinoma cell lines, 1283 binding on fibroblast growth factor 2 effects, 1399 Drug resistance trichosanthin immunogenicity lowering by coupling to, acidic vesicle turnover and resistance to chemotherapeu- 927 tic drugs and, 1047 Dextrin sulfate, HIV-1 tat protein interaction with, 775 cellular sensitivity to cisplatin, DNA mismatch repair DFMO: see DL-a-Difluoromethylornithine and, 861 Diabetes, advanced glycation end products and, 303 cisplatin, factors influencing, 347 Diabetic hypertrophy, glycosphingolipid synthesis slowing gemcitabine, activity in ara-C-resistant leukemia cell as chemotherapeutic tool and, 589 lines, 397 a,B8-Dicarbonyl, PTB mechanism of action and, 303 membrane-associated P-glycoprotein and, 1037 Diene, conjugated, fluvastatin sodium protective effects on Dynorphin A (1-13), cholinergic neuronal system modu- oxidative modification of low-density lipoproteins lation by, carbon monoxide-exposed mice, 1321 and, 697 Di-(2-ethylhexyl)phthalate, metabolism of phosphati- Ebselen, hydrogen peroxide-induced cytotoxicity and DNA dylethanolamine and phosphatidylcholine, in rat liver, damage effects, 273 869 Eicosatetraenoic acid, prostaglandin H synthase inhibition DL-a-Difluoromethylornithine (DFMO), polyamine metab- and 12-lipoxygenase activation by, in endothelial cells olism and, in African trypanosomes, 89 and platelets, 631 Dihydrofolate reductase, glycinamide ribonucleotide Electron paramagnetic resonance, nitric oxide levels in formyltransferase inhibitor and trimetrexate, 567 brain during ischemia-reperfusion, quercetin effects la,25-Dihydroxyvitamin D; growth inhibition and differ- on, rats, 199 entiation in leukemia and, 521 Electropermeabilization, bleomycin internalization and, 45 Diisopropyl phosphorofluoridate, mRNA expression of Elimination, ethanol, allometry model for prediction of, in neurofilament subunits in brain and spinal cord after, mammals, 219 hens, 1245 Endocytosis, receptor-mediated, bleomycin internalization DIM: see 2,3-Dimethoxy-1,4-Naphthoquinone and,4 5 2,3-Dimethoxy-1,4-Naphthoquinone, colon cancer cell Endothelial cells line effects, 27 dehydroepiandrosterone sulfate and, 329 Dimethyl sulfoxide, calmodulin-stimulated (Ca*~-Mg?~) - vascular, activation by factor Xa, 603 ATPase activity inhibition by, 39 Enzymes, brain, 2-arachidonoylglycerol hydrolysis by, 417 neeei e Volume Contents, Author and Subject Index for Volume 57, 1999 1469 Epidermal growth factor Fibroblast growth factor 2, dextran binding effects on, 1399 extracellular signal-regulated protein kinase regulation, Fluorescence activated cell sorting (FACS), TNF-a surface effects on mitogenesis, 425 expression enhancement by matrix metalloprotease oxidant-induced barrier disruption inhibition in Caco-2 inhibitors and, 291 cells monolayers by, 685 Flurbiprofen, B-oxidation and oxidative phosphorylation Epidermal growth factor receptors, inhibition with CL- inhibition by, 837 387,785, 917 Fluvastatin sodium, protective effects on oxidative modifi- Epithelial cells, bronchial, glucocorticoid receptor charac- cation of low-density lipoproteins, 697 terization in, 1003 fMLP: see Formyl-methionyl-leucyl-phenylalanine Epithelial peptide antibiotics, clinical studies of, 121 Folic acid, synergy for trimetrexate and glycinamide ribo- Equilibrium binding studies, allosteric modulation in mus- nucleotide formyltransferase inhibitor, 567 carinic receptors and, 171 Formyl-methionyl-leucyl-phenylalanine (fMLP), phospho- Escherichia coli, exonuclease III mediation of phosphogly- inositide metabolism and calcium release and, pirac- colate removal in, 531 etam effects and, 163 Estrogen receptors, interaction with estrogen response ele- Forskolin, P,; receptors influence on effects of, in cyclic ments, 597 AMP accumulation and export in PC12 cells, 355 Estrogen response elements, estrogen receptors interaction Fyn kinase, behavior regulation and, molecular mechanisms with, 597 of, ethanol sensitivity and, 845 Ethanol allometric model for predicting elimination of, in mam- Gallamine, UH-AH 37 interaction with muscarinic recep- mals, 219 tors and, 181 developmental neurotoxicity of, muscarinic cholinergic Gastric alcohol dehydrogenase, sex-dependent induction, receptor signal transduction as target for, 721 rats, 1067 [H]norharman binding to ethanol-inducible cyto- Gastropathy, NSAIDs and, indomethacin and naproxen chrome P450 2E1 in liver and, 511 interaction, 247 prenatal biosynthesis of all-trans-retinoic acid inhibition Gaucher’s disease, glucosphingolipid synthesis slowing and, by, 811 589 sensitivity, molecular mechanisms of Fyn kinase to reg- Geldanamycin, MAP kinase and, 281 ulate behavior and, 845 Gemcitabine sex-dependent induction, rats, 1067 activity in ara-C-resistant leukemia cell lines, 397 in utero exposure to, muscarinic cholinergic receptor etoposide and, effects, non-small cell lung and ovarian signal transduction and, 721 cancer, 407 2-Ethoxyethanol, sex-dependent induction, rats, 1067 Gene therapy Etoposide adenovirus attachment and internalization, receptors gemcitabine and, effects, non-small cell lung and ovarian mediating, 975 cancer, 407 glial cell line-derived neurotrophic factor and, 135 intracellular localization of Bax protein and, 143 Genetic vectors, adenovirus attachment and internaliza- Excision repair tion, receptors mediating, 975 cisplatin-DNA adducts, enhancement by cell-free ex- Gingival hyperplasia, phenytoin role in wound healing, tract from cisplatin-resistant rat cell line, 1415 1085 cross complementation group 1, cisplatin resistance in Glucocorticoid receptors, pharmacologic characterization ovarian cancer and, 347 in bronchial epithelial cells, 1003 Excitation-contraction coupling, ryanodine receptor regu- Glucose transport, regulation by IL-3 and oncogenes, 387 lation by reactive nitrogen species and, 1079 Glucosphingolipid synthesis, slowing of, as chemotherapeu- Exocytosis, of neutrophil granulocytes, 1209 tic tool, 589 Exonuclease III, mediation of phosphoglycolate removal in Glucuronidation, polycyclic aromatic hydrocarbon com- Escherichia coli, 531 pounds induction of UDP-glycuronosyltransferase isoforms and, 653 FACS: see Fluorescence activated cell sorting y-Glutamylcysteinylethy ester, effects on selenium-defi- Factor Xa, vascular endothelial cell activation by, 603 cient rat heart, 955 Fatty acids Glutathione, biotransformation system mediated by, pros- B-oxidation and oxidative phosphorylation inhibition by taglandin A, interaction with, 1383 NSAIDs and, 837 Glutathione homeostasis, tissue-specific regulation of, acti- oxygenation in platelets and endothelial cells, 631 vator protein-1 response in rat conceptus and, 1165 3-thia, as control site for ketogenesis, 1011 Glutathione peroxidase, selenium effects on thioredoxin »Fe-ferritin, mobilization evaluation of, 559 reductase activity and, rats, 187 Fenton reaction, iron deprivation as therapy and, 1345 Glycation end products, advanced, N-phenacylthiazolium Volume Contents, Author and Subject Index for Volume 57, 1999 bromide mechanism of action and, 303 Human immunodeficiency virus-1 Glyceraldehyde, pancreatic B-cell function studies and, 583 mechanism of anti-HIV activity of succinylated human Glycerolipid metabolism, platelet, chlorpromazine and, serum albumin, 889 1113 sulphated polysaccharides interaction with, 775 8-Glycuronidase, daunorubicin-GA3 distribution and Human immunodeficiency virus, chemokine receptors as pharmacokinetics in ovarian cancer xenografts, 673 therapy for, 451 Glyoxalase pathway, pancreatic B-cell function studies and, Hydrazine, methionine synthase activity effects, 1311 583 Hydrogen peroxide gp120 peptides, mechanism of anti-HIV activity of succi- chemically induced apoptosis of HL-60 cells, 1361 nylated human serum albumin and, 889 DNA damage in colon carcinoma cells and, 19 G-protein, a subunit of, in splice variants in cardiac tissue, oxidative stress induced by, docosahexenoic acid protec- 539 tive effects against, 1021 G-protein By subunit, mediation by opioid stimulation of Hydrophobic agents, DMSO role in dissolution of, 39 adenylyl cyclase activity in olfactory bulb, rats, 649 Hydroquinone, methyl gentisate evaluation as skin-light- Growth factors: see specific type ening agent and, 663 [°S]-Guanosine 5’-O-(y-thiotriphosphate), dopamine re- 6-Hydroxychrysene, mono- and diglucuronide formation ceptor activation in rat striatum and, 155 from, by UDP-glycuronosyltransferase isoforms, 653 Guanylyl cyclase, isatin efficacy as antagonists of atrial Hydroxyl radical, chemically induced apoptosis of HL-60 natriuretic peptide receptors coupled to, 913 cells and, 1361 Hydroxypyridinones Heart blood-brain barrier permeability and, correlation be- muscle, ryanodine receptor regulation by reactive nitro- tween structure of, 1305 gen species and, 1079 iron mobilization evaluation of, 559 oxidative phosphorylation inhibition and uncoupling by 5-Hydroxytryptamine, sodium-dependent, tetanus toxin in- NSAIDs and, 743 hibition by, in rat synaptosomes, 111 tissue, G.a isoforms in, 539 HeLa cells, copper, zinc-superoxide dismutase and catalase Ibuprofen overexpression effects on sensitivity to cis-platinum, B-oxidation and oxidative phosphorylation inhibition 545 by, 837 Hepatic alcohol dehydrogenase, sex-dependent induction, up-regulation of IL-1B and TNF-a and, 313 rats, 1067 Illudin, acylfulvene metabolism in rat liver cytosol and, 83 Hepatitis B virus, 3TC resistant, sensitivity to antiviral Imipramine, apoptosis induced by, reactive oxygen species nucleoside analogues, 1351 generation in mitochondrial membrane potential dur- Hepatocellular carcinoma, asialoglycoprotein receptor ex- ing, 1199 pression in, DNA synthesis inhibitors toxicity and, Immune function, NF-«B/Rel proteins and, 1 793 Immunity, innate, epithelial peptide antibiotics and, 121 Hepatocytes Immunogenicity, trichosanthin, lowering by coupling to angiotensin II receptor internalization and signaling in, dextran, 927 rats, 1125 Immunomodulation, cyclic nucleotide phosphodiesterase time-dependent production of nitric oxide by, rats, 1223 inhibitors and, 965 HepG,j cells, ebselen protective effects against cytotoxicity Immunoregulatory proteins, chemokine receptors, HIV and DNA damage in, 273 therapy and, 451 Histamine, polyamines and, involvement in tumor growth, Immunosuppression, glucosphingolipid synthesis slowing as 1341 chemotherapeutic tool and, 589 Histamine H; receptor antagonists, effects, tele-methylhis- Immunosuppressive agents, 15-deoxyspergualin, selectivity tamine levels, in rat cerebral cortex, 1059 of, 877 HIV: see Human immunodeficiency virus Immunotherapy, interleukin-2, hepatic cytochrome P450 HIV-1: see Human immunodeficiency virus-1 levels after, 951 HIV protease inhibitors, P-glycoprotein inhibition and, Indole acetic acid, horseradish peroxidase and, electrophilic 1147 oxidation products in cytotoxicity of, 375 HIV-1 tat protein, interaction with sulphated polysaccha- Indomethacin, naproxen and, gastric toxicity of NSAIDs rides, 775 and, 247 HN,.G-CoA reductase inhibitor, fluvastatin sodium protec- Infectious disease, iron deprivation as therapy and, 1345 tive effects on oxidative modification of low-density Inflammatory response, lipopolysaccharide-induced, bacte- lipoproteins and, 697 ricidal/permeability-increasing protein effects on, 225 Horseradish peroxidase, indole-3-acetic acid and, electro- Inhibitor-kBa, ibuprofen inhibition of, 313 philic oxidation products in cytotoxicity of, 375 INS-1D cells, alloxan-exposed, insulin release modulation