Biochemical Pharmacology 1997: Vol 54 Table of Contents

22 Pages·1997·5.1 MB·English

Biochemical Pharmacology
VOLUME 54, 1997
VOLUME CONTENTS AND AUTHOR INDEX
BIOCHEMICAL PHARMACOLOGY
REGIONAL EDITORS
American Continent European Continent
Prof. Alan C. Sartorelli Prof. Jacques E. Gielen
(Executive Editor) Université de Liége
Yale University School of Medicine Laboratoire de Chimie Medicale
Department of Pharmacology Centre Hospitalier Universitaire
Sterling Hall of Medicine, 333 Cedar Street B-4000, Sart-Tilman par Liége 1
PO Box 208066, New Haven, CT 06520-8066, U.S.A. Belgium
FAX (203) 737-2045 FAX [phone]
E-mail: [email protected]
ASSOCIATE EDITORS
Chemotherapy and
Metabolic Inhibitors Hormones and Growth Factors Molecular Biology
Prof. Yung-Chi Cheng Prof. Priscilla S. Dannies Dr. Tetsuya Kamataki
Yale University School of Medicine Yale University School of Medicine Division of Drug Metabolism
Department of Pharmacology Department of Pharmacology Faculty of Pharmaceutical Sciences
Sterling Hall of Medicine Sterling Hall of Medicine Hokkaido University
333 Cedar Street, PO Box 208066 333 Cedar Street, PO Box 208066 N12 W6, Sapporo
New Haven, CT 06520-8066, U.S.A. New Haven, CT 06520-8066, U.S.A. Hokkaido, 060 Japan
FAX (203) 785-7129 FAX (203) 737-2027 FAX [phone]
E-mail: [email protected] E-mail: [email protected]
Gene Expression and Transcription Factors and Gene
Development Regulation Neuropharmacology
Prof. Daniel W. Nebert Dr. Jacques Piette Prof. Gustave Moonen
Departments of Environmental Laboratoire de Virologie Service de Physiologie humaine
Health and of Pediatrics Institut de Pathologie et de Physiopathologie
University of Cincinnati Medical Center Bat B 25, Université de Liége Institut Léon Frédéricq
PO Box 670056 B-400 Sart-Tilman par Liége 1, Place Delcour
Cincinnati, OH 45267-0056, U.S.A. Belgium 17 Bat L1, 4020 Liége, Belgium
FAX (513) 558-0925 FAX [phone] FAX [phone]
E-mail: [email protected]
Neuroscience Commentaries Editor
Prof. Robert H. Roth Prof. Harold R. Behrman
Yale University School of Medicine Yale University School of Medicine
Department of Pharmacology Departments of Obstetrics,
Sterling Hall of Medicine Gynecology & Pharmacology
333 Cedar Street, PO Box 208066 Sterling Hall of Medicine
New Haven, CT 06520-8066, U.S.A. 333 Cedar Street, PO Box 208063
FAX (203) 785-4506 New Haven, CT 06520-8063, U.S.A.
FAX (203) 785-7134
E-mail: [email protected]
Managing Editor: Dr. Kim C. Healy, Yale University School of Medicine, Department of Pharmacology, 47 College
Street, Suite 227, New Haven, CT 06510-3209, U.S.A. FAX (203) 776-2381; E-mail: [email protected]
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AIMS AND SCOPE
BIOCHEMICAL PHARMACOLOGY is an international journal which publishes research findings in pharmacology deriving
from investigations that employ the disciplines of biochemistry, biophysics, molecular biology, genetics, structural
biology, computer models and/or physiology. Reports of studies with intact animals, organs, cells, subcellular
components, enzymes or other cellular molecules and model systems are acceptable if they define mechanisms of drug
action. Descriptive mathematical models including those involving computer techniques are also welcome. Experi-
ments involving the use of drugs to elucidate physiological and behavioral mechanisms in living organisms are also
within the scope of the journal. In general, papers that record concentrations of drugs and metabolites in body fluids
will only be accepted if they contribute to an understanding of biochemical and biophysical mechanisms. The Editors,
however, reserve the right to publish any papers of major interest in the field. Only contributions in English will be
considered or published.
The journal publishes the following types of communication:
(1) Full-length Papers. These consist of a body of work presenting original findings relating to the question proposed
by the investigators undertaking the research. ;
(2) Short Communications. These consist of an original body of work of narrower scope but of the same quality as
the above. By definition, these papers are shorter than full-length manuscripts.
(3) Rapid Communications. These promote rapid dissemination of timely and significant observations within the
scope of the journal. Manuscripts must be submitted in English and will be judged as appropriate for publication as rapid
communications on the basis of their immediate importance. They should be written to emphasize clearly the novel
aspects of the research. These criteria will be applied strictly.
(4) Commentaries are short commissioned review articles (3000-5000 words in length). They are designed to be
editorial statements on selected topics, and should not be exhaustive reviews. Primarily, Commentaries are intended to
stimulate thought. They can be controversial, and can either focus on areas subject to much activity, or draw attention
to relatively neglected fields in which there is both the opportunity and the need for research in biochemical
pharmacology. Particularly welcome will be Commentaries in which authors present their personal view on the state
of the subject on which they are reporting, and give their view as to where in the near or distant future the subject may
be moving. Authors are especially encouraged to take issue with popular dogmas. The Commentary series is edited by
Professor Harold R. Behrman.
While the final decision on selection of authors for Commentaries will be made at the discretion of The Editor,
suggestions from readers will be welcome. These should be addressed to: Professor H. R. Behrman, Department of
Pharmacology, Yale University School of Medicine, 333 Cedar Street, P.O. Box 208063, New Haven, Connecticut
06520-8063.
(5) Meeting Reports. The journal is prepared to publish as preliminary communications short, factual two-page
summaries of selected papers from small meetings or conferences. The meetings should be those where attendance is
by invitation and all papers to be published will be refereed. Organizers who wish to have their meetings published in
this way should contact the appropriate Regional Editor.
Notes for Contributors can be found in all issues and Abbreviations in issues 1 and 7.
EDITORIAL ADVISORY BOARD
American Continent
M. C. BinER—Virginia Commonwealth University, Richmond, VA A. B. Oxey—University of Toronto, Ontario, Canada
M. J. BROWNSTEIN—National Institutes of Health, Bethesda, MD C. J. OMIECINSKI—University of Washington, Seattle, WA
M. S. CHEN—Gilead Science, Foster City, CA W. B. ParkKER—Southern Research Institute, Birmingham, AL
S. F. CHeN—Institute for Drug Development, San Antonio, TX G. PizzorNo—Yale University School of Medicine, New Haven, CT
E. CHU—Yale University School of Medicine, New Haven, CT G. L. PLAaA—University of Montreal, Quebec, Canada
G. CoHEN—Mount Sinai School of Medicine, New York, NY
A. PUGA—University of Cincinnati Medical Center, Cincinnati, OH
I. CrEESE—State University of New Jersey, Newark, NJ
E. RICHELSON—Mayo Clinic, Jacksonville, FL
D. G. DeuTscH—State University of New York, Stony Brook, NY
A. B. RirkiNpb—Cornell University Medical College, New York, NY
B. J. DoLNIcK—Roswell Park Cancer Institute, Buffalo, NY
J. A. RorH—State University of New York, Buffalo, NY
E. G. Erpos—University of Illinois, Chicago, IL
C. O. RUTLEDGE—Purdue University, West Lafayette, IN
J. N. Fain—University of Tennessee, Memphis, TN
P. R. SINCLAIR—VA Research Service, White River Junction, VT
R. GANAPATHI—Cleveland Clinic Foundation, Cleveland, OH
B. TABAKOFF—University of Colorado Health Sciences Center, Denver,
T. A. GaAsiEwicz—University of Rochester, Rochester, NY
CO
R. I. GLAZER—Georgetown University Medical Center, Washington,
S. S. THORGIERSSON—National Institutes of Health, Bethesda, MD
D.C.
A. J. TOwNSEND—Bowman Gray School of Medicine, Winston-Salem,
I. D. GOLDMAN—Albert Einstein College of Medicine, Bronx, NY
NC
W. F. GREENLEE—University of Massachusetts Medical Center,
D. J. TriGGLE—State University of New York, Buffalo, NY
Worcester, MA
F. P. GUENGERICH—Vanderbilt University, Nashville, TN M. VAUGHAN—National Institutes of Health, Bethesda, MD
P. A. WaTkKINS—Johns Hopkins University School of Medicine,
M. R. HANLEY—University of California, Davis, CA
H. KALANT—University of Toronto, Ontario, Canada Baltimore, MD
F. MATSUMURA—University of California, Davis, CA H. WeineR—Purdue University, West Lafayette, IN
M. McKINNEY—Mayo Clinic, Jacksonville, FL N. WEINER—University of Colorado Health Sciences Center, Denver,
H. Y. MELTZER—Case Western Reserve University, Cleveland, OH CO
E. J. NESTLER—Yale University School of Medicine, New Haven, CT J. R. WittiaMson—University of Pennsylvania School of Medicine,
L. M. NuTTER—University of Minnesota, Minneapolis, MN Philadelphia, PA
European Continent
K. W. Bock—Tiibingen University, Tiibingen, Germany H. NouL_—Veterinary University of Vienna, Vienna, Austria
A. R. Boosis—Hammersmith Hospital, London, U.K. F. OgscH—University of Mainz, Mainz, Germany
P. H. BEAUNE—Chu Necker, Paris, France K. PArK—University of Liverpool, Liverpool, U.K.
J. CALDWELL—Imperial College School of Medicine, London, U.K. J. PierrE—Université Paris XI, Chatenay-Malabry, France
R. A. J. CHALLIS—University of Leicester, Leicester, U.K. E. REINER—Institute for Medical Research and Occupational Health,
T. A. CONNoRS—University of London, London, U.K.
Zagreb, Croatia
E. De CLERCQ—University of Leuven, Leuven, Belgium
J. ReMACLE—Facultes Universitaires Notre-Dame de la Paix, Namur,
J.-M. FrerE—Université de Liége, Liége, Belgium
Belgium
T. GOpFRAIND—University of Leuven, Brussels, Belgium
A. G. ReNwick—University of Southampton, Southampton, U.K.
M. HAMON—Institut National de La Sauté et de La Recherche
P. J. Roperts—University of Bristol, Bristol, U.K.
Médicale, Paris, France
K. SCHULZE-OsTHOFF—A lbert-Ludwigs-University, Freiburg, Germany
J. HANOUNE—Hopital Henri Mondor, Creteil, France
J. Skopa—Institute of Organic Chemistry and Biochemistry, Prague,
J. A. HickMAN—University of Manchester, Manchester, U.K.
Czech Republic
P. JENNER—King’s College, London, U.K.
L. L. SmrrH—University of Leicester, Leicester, U.K.
H. Kappus—Humboldt Universitat, Berlin, Germany
D. MANsuy—Université René Descartes, Paris, France B. Testa—University of Lausanne, Lausanne, Switzerland
G. MILLIGAN—University of Glasgow, Glasgow, Scotland, U.K. K. F. TietoN—University of Dublin, Dublin, Ireland
P. Mo_pEus—Astra AB, Sédertalje, Sweden V. ULLRICH—Universitat Konstanz, Konstanz, Germany
G. J. MULDER—University of Leiden, Leiden, The Netherlands P. C. WALDMEIER—Ciba-Geigy, Ltd., Basel, Switzerland
K. J. NeTTER—University of Marburg, Marburg, Germany M. B. H. Youpim—Rappaport Family Research Institute, Haifa, Israel
Asia and Pacific Rim
SHIN-CHI AlZAWA—Kumamoto School of Medicine, Kumamoto, Japan N. Miki—Osaka University School of Medicine, Osaka, Japan
Y.-N. CHA—Inha University School of Medicine, Inchon, Korea M. MisHINA—University of Tokyo, Tokyo, Japan
C. C. CHANG—National Science Council, Taipei, Taiwan TakU NAGAO—University of Tokyo, Tokyo, Japan
K. CHinA—Chiba University, Chiba, Japan S. NARUMIYA—Kyoto University, Kyoto, Japan
COMMENTARIES EDITORIAL ADVISORY BOARD
M. R. Boypb—National Institutes of Health, Bethesda, MD J. MELDOLEsI—Istituto di Ricovero e Cura a Carattere Scientifico,
H. EsTERBAUER—University of Graz, Graz, Austria Milano, Italy
Y. Fujl-KurlyAMA—Tohoku University, Sendai, Japan A. ScHoussporE—Royal Danish School of Pharmacy, Copenhagen,
N. J. MAcLUsky—University of Toronto, Ontario, Canada Denmark

CONTENTS OF VOLUME 54
1 JULY 1997
Commentaries
C. NORMAN GILLIS Panax ginseng pharmacology: A nitric oxide link?
SALVADOR F. ALINO Long-term expression of the humam al-antitrypsin gene in mice
employing anionic and cationic liposome vector
Rapid Communication
KRISTOPHER W. KRAUSZ, TIAN JIAN YANG, 15 Inhibitory monoclonal antibodies to human cytochrome P450 2D6
FRANK J. GONZALEZ, MAGANG SHOU and
HARRY V. GELBOIN
Research Papers
NATHALIE LEGAULT, HASSAN SABIK, SAM F. 19 Effect of estradiol on the induction of porphyria by hexachlorobenzene
COOPER and MICHEL CHARBONNEAU in the rat
LisA CAssIs, UJJWALA SHENOY, DAVID LIPKE, 27 Lung angiotensin receptor binding characteristics during the
JENNIFER BAUGHN, MICHAEL FETTINGER and development of monocrotaline-induced pulmonary hypertension
MARK GILLESPIE
MITCHELL A. HAMMAN, GARY A. THOMPSON 33 Regioselective and stereoselective metabolism of ibuprofen by human
and STEPHEN D. HALL cytochrome P450 2C
ANDREJS M. KRUMINS, JEAN-NUMA LAPEYRE, 43 Evidence for the shuttle model for G.a activation of adenylyl cyclase
RICHARD B. CLARK and ROGER BARBER
ANDREJS M. KRUMINS and ROGER BARBER 61 Examination of the effects of increasing G, protein on B-adrenergic
receptor, G., and adenylyl cyclase interactions
LAUREN A. TREPANIER, KUNAL RAY, NENA J. 73 Cytosolic arylamine N-acetyltransferase (NAT) deficiency in the dog
WINAND, STEPHEN P. SPEILBERG and and other canids due to an absence of NAT genes
ALASTAIR E. CRIBB
JOHN DUNLOP, NEIL BRAMMER, NON EVANS 81 YM022 [R-1-[2,3-dihydro-1-(2’-methylphenacyl)-2-oxo-5-phenyl-1H-
and CHRIS ENNIS 1,4-benzodiazepin-3-yl]-3-(3-methylphenyl)urea]: An irreversible
cholecystokinin type-B receptor antagonist
DANIEL HWANG, BYEONG C. JANG, GANG YU 87 Expression of mitogen-inducible cyclooxygenase induced by
and MARY BOUDREAU lipopolysaccharide: Mediation through both mitogen-activated protein
kinase and NF-«B signaling pathways in macrophages
LEE-YONG KHIL, AE JIN CHEON, TONG-SHIN 97 Effects of calcium on brazilin-induced glucose transport in isolated rat
CHANG and CHANG-KIU MOON epididymal adipocytes
GEORGE L. DEGEORGE, DIANE E. HECK and 103 Arginine metabolism in keratinocytes and macrophages during nitric
JEFFREY D. LASKIN oxide biosynthesis
ZHIBIN REN, CHARLES E. ELSON and 113 Inhibition of type I and type II geranylgeranyl-protein transferases by
MICHAEL N. GOULD the monoterpene perillyl alcohol in NIH3T3 cells
MASOUD GHORBANI, THOMAS H. CLAUS and 121 Hypertrophy of brown adipocytes in brow and white adipose tissue and
JEAN HIMMS-HAGEN reversal of diet-induced obesity in rats treated with a B;-adrenoceptor
agonist
KAREN S. CABELL, LIN MA and 133 Effects of antihypertensive drugs on rat tissue antioxidant enzyme
PETER JOHNSON activities and lipid peroxidation levels
TAKASHI YAMASHIRO, NAOKO WATANABE and 143 Reduction of intracellular pH by inktbitors of natural killer cell activity,
YOSHIRO KOBAYASHI nicardipine, methyl 2-(N-benzyl-N-methylamino)ethyl-2,6-dimethyl-4-
(2-isopropyl-pyrazolo[1 ,5-alpyridine-3-yl)-1,4-dihydro-pyridine-3,5-
dicarboxylate (AHC-52), and 4,4'-diisothiocyano-2,2'-disulfonic acid
stilbene (DIDS)
PAUL B. WEISZ, MADELEINE M. JOULLIE, 149 A basic compositional requirement of agents having heparin-like cell-
CATHRINE M. HUNTER, KATHLEEN M. KUMOR, modulating activities
ZHONGDA ZHANG, ELLIOT LEVINE, EDWARD
MACARAK, DAVID WEINER and ELLIOT S.
BARNATHAN
JEFFREY A. HANDLER and WILLIAM R. BRIAN 159 Effect of aging on mixed-function oxidation and conjugation by isolated
perfused rat livers
Vii
Vill List of Contents and Author Index for Volume 54, 1997
DIETER SCHRENK, DIRK RIEBNIGER, MARKUS 165 Tryptanthrins: A novel class of agonists of the aryl hydrocarbon
TILL, SILVIA VETTER and HANS-PETER FIEDLER receptor
INGRID DE MEESTER, ALEXANDER BEYAEV, 173 In vivo inhibition of dipeptidyl peptidase IV activity by pro-pro-
ANNE-MARIE LAMBEIR, GUIDO R. Y. DE diphenyl-phosphonate (prodipine)
MEYER, NANCY VAN OSSELAER, ACHIEL
HAEMERS and SIMON SCHARPE
GUANG JIAN WANG, LOUISE M. NUTTER and 181 Insensitivity of cultured rat cortical neurons to mitochondrial DNA
STANLEY A. THAYER synthesis inhibitors: Evidence for a slow turnover of mitochondrial
DNA
DELYTH A. ADAMS, ROBERT J. EDWARDS, 189 Specific inhibition of human CYP1A2 using a targeted antibody
DONALD S. DAVIES and ALAN R. Boopsis
BENJAMIN L. J. WEBB, MARK A. LINDSAY, 199 Identification of the protein kinase C isoenzymes in human lung and
JOACHIM SEYBOLD, NIGEL J. BRAND, MAGDI H. airways smooth muscle at the protein and mRNA level
YACOUB, EL-BDAOUI HADDAD, PETER J.
BARNES, IAN M. ADCOCK and MARK A.
GIEMBYCZ
Short Communications
F. BERNARDO PLIEGO-RIVERO, NADHIM Brain-derived neurotrophic factor in human platelets
boi o}~ ]
BAYATTI, XENOPHON GIANNAKOULOPOULOS,
VIVETTE GLOVER, HENRY F. BRADFORD,
GERALD STERN and MERTON SANDLER
IRIT HALILI-RUTMAN, CHAIM HERSHKO, 211 Inhibition of calcium accumulation by the sarcoplasmic reticulum: A
GAVRIELA LINK, AVRAM J. RUTMAN and putative mechanism for the cardiotoxicity of adriamycin
ASHER SHAINBERG
LUCIA SABORDO and BENEDETTA C. SALLUSTIO 215 Effects of gemfibrozil and clofibric acid on the uptake of taurocholate by
isolated rat hepatocytes
15 JULY 1997
Commentary
ALEKSANDAR JOVANOVIC, ALEXEY E. ALEKSEEV 219 Intracellular diadenosine polyphosphates: A novel family of inhibitory
and ANDRE TERZIC ligands of the ATP-sensitive K* channel
Research Papers
ZHAO-JUN DONG, LI-JUAN CHEN, GUO-ZHANG 227 GTP regulation of (—)-stepholidine binding to Ry, of D,; dopamine
JIN and IAN CREESE receptors in calf striatum
LING-LONG ZOU, JIAN LIU and GUO-ZHANG 233 Involvement of receptor reserve in D1 agonistic action of (—)-
JIN stepholidine in lesioned rats
Upay BANDYOPADHYAY, RATNA CHATTERJEE, 241 Activation of parietal cell by mercaptomethylimidazole: A novel
TAPAN K. CHAKRABORTY, CHAYAN K. inducer of gastric acid secretion
GANGULY, DiIPAK K. BHATTACHARYYA and
RANAJIT K. BANERJEE
JAMES H. ELWELL, BRONWYN G. SIIM, 249 Adaptation of human tumor cells to tirapazamine under aerobic
JAMES W. EVANS and J. MARTIN BROWN conditions: Implications of increased antioxidant enzyme activity to
mechanism of aerobic cytotoxicity
TONG-SHIN CHANG, HYUN-MEE KIM, KI-SEON 259 Thromboxane A, synthase inhibition and thromboxane A, receptor
LEE, LEE-YONG KHIL, WOONG-CHON MAR, blockade by 2-[(4-cyanophenyl)amino]-3-chloro-1,4-naphthalenedione
CHUNG-KYU RyU and CHANG-KIU MOON (NQ-Y15) in rat platelets
ASHIMA SAXENA, DONALD M. MAXWELL, 269 Mutant acetylcholinesterases as potential detoxification agents for
DANIEL M. QUINN, ZORAN RADIC, PALMER organophosphate poisoning
TAYLOR and B. P. Doctor
PAUL L. ELSE and KYLIE MANSFIELD 275 Activation of sodium transport and intracellular sodium lowering by the
neuroleptic drug chlorpromazine
List of Contents and Author Index for Volume 54, 1997 ix
MACIE] WIECZOREK, ANNA PILYAVSKAYA, 283 Bradykinin antagonists in human systems: Correlation between receptor
MICHAEL BURKARD, JOHN S. ZUZACK, STEVEN binding, calcium signalling in isolated cells, and functional activity in
W. JONES, MARY D. FRANCIS, VIRGINIA E. isolated ileum
BECKLEY, SHERMAN E. Ross, VAL S.
GOODFELLOW, TIMOTHY D. FITZPATRICK,
MANO] V. MARATHE, ALBERT GYORKOS, LYLE
W. SPRUCE, WILLIAM M. SELIG, JOHN M.
STEWART, LAJOS GERA and ERIC T. WHALLEY
JEAN-CLAUDE FERAY, KAMIAR MOHAMMADI, 293 Fenspiride and membrane transduction signals in rat alveolar
KARIMA TAQUIL, JOHN BRUNET, RICARDO P. macrophages
GARAY and PATRICK HANNAERT
FRANCO GHEZZO, GIOVANNI N. BERTA, 299 Calcyclin gene expression modulation by medroxyprogesterone acetate
MARISA BECCARO, ANTONIO D’AVOLIO, SILVIA
RACCA, GIUSEPPE CONTI and FRANCESCO DI
CARLO
SANDRA GRADELET, PIERRE ASTORG, THIERRY 307 Ah receptor-dependent CYPIA induction by two carotenoids,
PINEAU, MARIE-CHANTAL CANIVENC, canthaxanthin and B-apo-8’caotenal, with no affinity for the TCDD
MARIE-HELENE SIESS, JOEL LECLERC and binding site
PIERRE LESCA
Short Communications
Siu-Po Ip, CUl-YING MA, CHUN-TAO CHE and 317: Methylenedioxy group as determinant of schisandrian in enhancing
KAM-MING KO hepatic mitochondrial glutathione in carbon tetrachloride-intoxicated
mice
ALBERT ENZ and ESTABAN POMBO-VILLAR 321 Class II pyrethroids: Noninhibitors calcineurin
1 AUGUST 1997
Commentaries
JOHN D. HILDEBRANDT 325 Role of subunit diversity in signaling by herterotrimeric G proteins
JORGE R. BARRIO, SUNG C. HUANG AND 341 Biological imaging and the molecular basis of dopaminergic diseases
MICHAEL E. PHELPS
Research Papers
AMEL DAHMANE, SOPHIE GIL, FREDERIC 349 Differential effect of vanadate on receptor-mediated endocytosis of the
CROQUET, JEAN DAvy and JEANNE FEGER asialoglycoprotein receptor in hepatocytes from normal and diabetic rats
GIUSEPPINA Di STEPHANO, FRANCESCO P. 357 Ribavirin conjugated with lactosaminated Poly-L-lysine: Selective
COLONNA, ALESSANDRO BONGINI, CORRADO delivery to the liver and increased antiviral activity in mice with viral
Busi, ALESSANDRO MATTIOLI and LUIGI FIUME hepatitis
KATJA ZURBONSEN, ALAIN MICHEL, DANIEL 365 Antiproliferative effects of imidazo[1,2-a]pyrazine derivatives on the
VITTET, PIERRE-ANTOINE BONNET and Dami cell line
CLAUDE CHEVILLARD
MORTEN SORENSEN, MAXWELL SEHESTED and 373 pH-Dependent regulation of camptothecin-induced cytotoxicity and
PETER BUHL JENSEN cleavable complex formation by the antimalarial agent chloroquine
AMITABHA LALA, HAKIMUDDIN T. SOJAR and 381 Expression and purification of recombinant human N-formyl-L-leucyl-L-
ERNESTO DE NARDIN phenylalanine (FMLP) receptor: Generation of polyclonal antibody
against FMLP receptor
MARTIN CARLI, MARC MORISSETTE, CAROLINE 39] Effects of a chronic lithium treatment on central dopamine
HEBERT, THERESE Di PAOLO and neurotransporters
TomAs A. READER
MARIA DE FATIMA M. LAZARI, CATARINA S. 399 Receptor-mediated endocytosis of angiotensin II in rat myometrial cells
PORTO, EDNA FREYMULLER, LYGIA C. ABREU
and ZULEIKA P. PICARELLI
GARRY J. SOUTHAN, DOUGLAS GOULD, 409 Inhibition of nitric oxide synthase with pyrazole-1-carboxamidine and
ANDREW LUBESKIE, BASILIA ZINGARELLI, related compounds
SALVATORE CUZZOCREA, ANDREW L. SALZMAN,
CSABA SZABO and DONALD J. WOLFF
List of Contents and Author Index for Volume 54, 1997
Short Communications
SONIA URIBE-LUNA, JUAN D. QUINTANA-HAU, 419 Mutagenic consequences of the incorporation of 6-thioguanine into
ROGELIO MALDONADO-RODRIGUEZ, DNA
M. ESPINOSA-LARA, KENNETH L. BEATTIE,
DAVID FARQUHAR and J. ARLY NELSON
MICHAEL W. SINZ and THOMAS F. WOOLF 425 Characterization of the induction of rat microsomal cytochrome P450
by tacrine
15 AUGUST 1997
Commentary
ANDREW J. MORRIS and SUZANNE SCARLATA 429 Regulation of effectors by G-protein a- and By- subunits: Recent
insights from studies of the phospholipase c-B isoenzymes
Research Papers
MANLIO BOLLA, PAOLA CARUSO, MASSIMO 437 Comparative analysis of isolated human bronchi contraction and
Glossi, GIANCARLO FOLCO, MAURIZIO CIVELLI biosynthesis of cysteinyl leukotrienes using a direct 5-lipoxygenase
and ANGELO SALA inhibitor
443
NEIL T. ENGLISH and LORNA C. RANKIN Antioxidant-mediated attenuation of the induction of cytochrome
P450BM-3(CYP102) by ibuprofen in Bacillus megaterium ATCC 14581
MARK LOYEVSKY, CHRISTY JOHN, IVAN 451 Aminothiol multidentate chelators as antimalarials
ZALOUJNYI and VICTOR GORDEUK
JUNE P. DAvis and ROBERT A. COPELAND 459 Histidine to alanine mutants of human dihydroorotate dehydrogenase:
Identification of a brequinar-resistant mutant enzyme
SUNG Ho Woo, MARC C. REYNOLDS, NAN 467 Inhibition of topoisomerase II by liriodenine
JUN SUN, JOHN M. CASSADY and ROBERT M.
SNAPKA
JAN G.R. ELFERINK, TOM W.J. HUIZINGA and 475 The effect of pentoxifylline on human neutrophil migration: A possible
BEN M. DE KOSTER role for cyclic nucleotides
HERBERT KEMMER, DIDIER TRIPIER, KARIN 481 Binding proteins for cyclic and linear oligopeptides in plasma
JOUVENAL, DOROTHEE SCRIBA, GIANCARLO membranes and the cytosol of rat hepatocytes
ZANOTTI, ANNA MARIA MAIONE and
KORNELIA ZIEGLER
NELSON AGUILA-MANSILLA, BERTIS B. LITTLE, 491 Differential potencies of cocaine and its metabolites, cocaethylene and
RAYMOND H. Ho and AYALLA BARNEA benzoylecgonine, in suppressing the functional expression of
somatostatin and neuropeptide Y producing neurons in cultures of fetal
cortical cells
JOLANTA B. ZAWILSKA, AGATA WOLDAN- 501 Histamine-stimulated cyclic AMP formation in the chick pineal gland:
TAMBOR and JERZY Z. NOWAK Role of protein kinase C
PHILIPPE GOURLET, ANDRE VANDERMEERS, 509 Vasoactive intestinal peptice (VIP) and pituitary adenylate cyclase-
PATRICK ROBBERECHT and MONIQUE activating peptide (PACAP-27, but not PACAP-38) degradation by the
DESCHODT-LANCKMAN neutral endopeptidase EC 3.4.24.11
ANDREW W. STANDEVEN, MARIA ESCOBAR, 517 Mitogenic effect of retinoid X receptor agonists in rat liver
RICHARD L. BEARD, YANG-DAR YUAN and
ROSHANTHA A.S. CHANDRARATNA
Short Communications
DARRELL A. JACKSON and NEIL N. 525 Regulation of expression and function of m2 and m4 muscarinic
NATHANSON receptors in cultured embryonic chick heart cells by transforming
growth factor-B,
HIROSHI SUZUKI, DAIJI MIYAUCHI and SHOZO 529 A selective inhibitor of arachidonate 5-lipoxygenase scavenging
YAMAMOTO peroxide activator