Biochemical Pharmacology 1994: Vol 48 Table of Contents

23 Pages·1994·4.4 MB·English

BIOCHEMICAL
PHARMACOLOGY
AN INTERNATIONAL JOURNAL
VOLUME 48, 1994
VOLUME CONTENTS AND AUTHOR INDEX
©
PERGAMON
BIOCHEMICAL PHARMACOLOGY
REGIONAL EDITORS:
American Continent European Continent
Prof. Alan C. Sartorelli Prof. Jacques E. Gielen
(Executive Editor) Université de Liége
Yale University School of Medicine Laboratoire de Chimie Medicale
Department of Pharmacology Centre Hospitalier Universitaire
Sterling Hall of Medicine, 333 Cedar Street B-4000, Sart-Tilman par Liége |
PO Box 208066, New Haven, CT 06520-8066, U.S.A. Belgium
ASSOCIATE EDITORS:
Chemotherapy Endocrinology Drug Metabolism
Prof. Yung-Chi Cheng Prof. Priscilla S. Dannies Dr. Tetsuya Kamataki
Yale University School of Medicine Yale University School of Medicine Division of Drug Metabolism
Department of Pharmacology Department of Pharmacology Faculty of Pharmaceutical Sciences
Sterling Hall of Medicine Sterling Hall of Medicine Hokkaido University
333 Cedar Street, PO Box 208066 333 Cedar Street, PO Box 208066 N12 W6, Sapporo
New Haven, CT 06520-8066, U.S.A. New Haven, CT 06520-8066, U.S.A. Hokkaido, 060 Japan
Genetics Immunopharmacology Neurobiology
Prof. Daniel W. Nebert Prof. Martin K. Church Prof. Gustave Moonen
Department of Environmental Department of Service de Physiologie humaine
Health, University of Cincinnati Clinical Pharmacology et de Physiopathologie
Medical Center, Kettering Centre Block, Southampton Institut Léon Frédéric
Laboratory, 3223 Eden Avenue General Hospital Place Delcour
Cincinnati, OH 45267-0056, U.S.A. Southampton SO9 4XY, U.K. 17 Bat LI, 4020 Liége, Belgium
Neuroscience Commentaries Editor
Prof. Robert H. Roth Prof. Harold R. Behrman
Yale University School of Medicine Yale University School of Medicine
Department of Pharmacology Departments of Obstetrics,
Sterling Hall of Medicine Gynecology & Pharmacology
333 Cedar Street, PO Box 208066 Sterling Hall of Medicine
New Haven, CT 06520-8066, U.S.A. 333 Cedar Street, PO Box 208063
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EDITORIAL ADVISORY BOARD
American Continent
Jutius AxeLrop—National Institutes of Health, Bethesda, Yutaka KosayasHi—Ko-By Associates, 60 Audubon Road,
MD Wellesley, MA
MicuaeL R. Boyo—LDDRD, Deveiopmental Therapeutics Wa ter M. LovenseRG—Marion Merrell Dow Research
Program, National Cancer Institute, Frederick, MD Institute, Cincinnati, OH
Epwarp Bresnick—University of Massachusetts Medical P. N. MaGee—Thomas Jefferson University, Cancer Institute,
Centre, 55 Lake Avenue North, Worcester, MA Philadelphia, PA
D. N. BrinDLEY—-Faculty of Medicine, University of Alberta, G. J. MANnnerinc—Department of Food Science and
Edmonton, Canada Nutrition, University of Minnesota, St. Paul, MN
MicuHaet J. Brownstein—National Institutes of Health, Tac E. MAnsour—Department of Pharmacology, Stanford
Bethesda, MD University Medical Center, Stanford, CA
Jack R. Cooper—Yale University School of Medicine, New Paut B. McCay—Oklahoma Medical Research Foundation,
Haven, CT Oklahoma City, OK
James K. Cowarp—College of Pharmacy, University of Hersert Y. MeELtzeER—Case Western Reserve University,
Michigan, Ann Arbor, MI Cleveland, OH
Ian Creese—Center for Molecular and Behavioral Neuro- EsteBAN Mezey—Johns Hopkins University School of
science, Aidekman Research Center, Newark, NJ Medicine, Baltimore, MD
Joun W. Dacy—National Institutes of Health, Bethesda, MD Danie. W. Nesert—Department of Environmental Health,
Erwin G. Erpés—Department of Pharmacology, University University of Cincinnati, Cincinnati, OH
of Illinois, College of Medicine, Chicago, IL Cuarces A. Nicho.—Cannam Enterprises, 1508 Ward Street,
a ErecinskA—University of Pennsylvania, Philadelphia, Durham, NC
A Rosert E. Parks, Jk—Brown University, Providence, RI
Ray W. Futter—Lilly Research Laboratories, Indianapolis,
IN Gasriet L. PLaa—University of Montreal, Quebec, Canada
Rosert C. Ga_to—National Institutes of Health, Bethesda, — Roserts—City of Hope Medical Center, Duarte,
MD
James R. Gittetre—National Institutes of Health, Bethesda, Jerome A. RotH—State University of New York, Medical
MD Center, Buffalo, NY
Rosert I. GLazer—Georgetown University, Washington, DC Cuarces O. RutLepGe—School of Pharmacy, Purdue Univer-
I. Davip GotpbMAN—Meedical College of Virginia, Richmond, sity, West Lafayette, IN
VA Boris TABAKOFF— University of Colorado School of Medicine,
THeopore E. GraM—1036 Welsh Drive, Rockville, MD Denver, CO
M. R. HanLtey—School of Medicine, University of California, JoHN F. TALLMAN—Neurogen, 35 Northeast Industrial Road,
Davis, CA Branford, CT
G. H. Hitcuincs—|! Carolina Meadows 102, Chapel Hill, Snorri Sv. THORGEIRSSON—National Institutes of Health,
NC Bethesda, MD
Louis J. IgNarro—UCLA School of Medicine, Department MARTHA VAUGHAN—National Institutes of Health, Bethesda,
of Pharmacology, Los Angeles, CA MD
WiuiaM B. Jakosy—National Institutes of Health, Bethesda, NorMan Weiner—University of Colorado Health Sciences
MD Center, Denver, CO
Davivp G. Jouns—National Institutes of Health, Bethesda, ARNOLD D. Wetcu (Chairman)—Frederick Cancer Research
MD Facility of National Cancer Institute, Frederick, MD
Haro_p KaLant—University of Toronto, School of Medicine, Joun R. WittiaMson—University of Pennsylvania, Philadelphia,
Toronto, Ontario, Canada PA
European Continent
F. M. Becparre—J. F. and C. Heymans Institute of Pharma- G. MitiGAn—Department of Biochemistry, University of
cology, Rijksuniversity, Ghent, Belgium Glasgow, Glasgow, U.K.
A. G. H. BLakeLey—Department of Physiology, The Univer- P. Mo_peus—Department of Toxicology, Karolinska Insti-
sity, Leicester, U.K. tute, 104 01 Stockholm 60, Sweden
K. W. Bocx—Institute of Toxicology, Tiibingen University, G. J. Mu._per—Department of Toxicology, University of
Germany Leiden, Sylvius Laboratories, P.O. Box 9503, 2300 RA
J. CaLpwe_t—St. Mary's Hospital Medical School, London, Leiden, The Netherlands
U.K K. J. NetreR—Department of Pharmacology and Toxicology,
R.A. J. Cua.tiss—Department of Pharmacology, University Philipps University, Marburg, Germany
of Leicester, Leicester, U.K. H. Nox_—Institute of Pharmacology and Toxicology, Uni-
T. A. Connors—lInstitute of Cancer Research, Sutton, Surrey, versity of Vienna, Vienna, Austria
U.K A. J. Paine—St Bartholomew's Hospital Medical School,
E. De CLercg—Rega Institute for Medical Research, Univer- London, U.K.
sity of Leuven, Belgium B. K. Pank—Department of Pharmacology and Therapeutics,
J. Frere—Institute de Chimie, Universite de Liége, Liége, University of Liverpool, Liverpool, U.K.
Belgium E. Reip—Guildford Academic Associates, Guildford, Surrey,
T. Goprrainp—Université Catholique de Louvain, Labora- U.K
toire de Pharmacclogie, Bruxelles, Beigium E. Reiner—Yugoslav Academy of Sciences and Arts, 4100
R. J. GryGiewski—School of Medicine, Cracow, Poland Zagreb, Croatia
J. Hamon—INSERM U288, Neurobiol Cellulaire et Fonc- A. G. Renwick—University of Southampton, Faculty of
tionnelle, Faculté de Medecine Pitie-Salpetriere, 91 Blvd de Medicine, Southampton, U.K.
l'Ho6pital, F-75634 Paris Cedex 14, France P. J. Roserts—Department of Pharmacology, University of
J. Hanoune—INSERM U99, Hopital Henri Mondor, Creteil, Bristol, Bristol, U.K.
France M. SANDLeExX—Bernhard Baron Memorial Research Labora-
J. A. HickmMan—Department of Physiological Sciences, tories, Queen Charlotte's Maternity Hospital, London, U.K.
University of Manchester, Manchester, U.K. H. Sies—Institut fiir Physiologische Chemie 1, Universitat
I. Jank0—Academy of Sciences of the Czech Republic, Diisseldorf, Diisseldorf, Germany
Institute of Pharmacology, Videnska 1083, CZ-14220 J. Skopa—Institute of Organic Chemistry and Biochemistry,
Praha 4 KRC, Czech Republic Czechoslovak Academy of Sciences, Prague, Czech
P. Jenner—Department of Pharmacology, King’s College, Republic
London SWS 8AF, U.K. Lewis L. SmitH—MRC Toxicology Unit, University of
H. Kappus—Freie Universitat Berlin, Germany Leicester, PO Box 138, Leicester Road, Leicester, U.K.
J. LunpperG—Department of Pharmacology, Karolinska B. Tesra—Department of Pharmacy, University of Lausanne,
Institute, Stockholm, Sweden Lausanne, Switzerland
G. P. Mannaerts—Dienst Farmakoligie, Campus Gasthuis- K. Tipton—Department of Biochemistry, University of
berg, Onderwijs en Navorsing, Herestraat, 3000 Leuven, Dublin, Trinity College, Ireland
Belgium V. Uttrich—Fakultét fiir Biologie, Universitat Konstanz,
D. Mansuy—Université René Descartes, Laboratoire de Chimie Konstanz, Germany
et de Biochemie, Pharmacologiques et Toxicologiques, 45 D. C. U’Pricharp—ICI Pharmaceuticals, Research II Dept,
rue des Saints-Péres, 75270 Paris Cédex 05, France Mereside Alderley Park, Macclesfield, Cheshire, U.K.
A. E. M. McLean—Department of Clinical Pharmacology, P. WALDMEIER—Ciba-Geigy Limited, CH-4002 Basle, Switzer-
University College Hospital Medical School, London, land
U.K M. B. H. Youpim—Technion-lIsrael Institute of Technology,
es ‘Meave—Department of Pharmacology, Boehringer Faculty of Medicine, Department of Pharmacology, Bat
Ingelheim KG, 55216 Ingelheim am Rhein, Germany Galim, Haifa, Israel
Asia and Pacific Rim
YounG-Nam Cua—Inha University, Inchon, Korea T. Watase—Tokyo College of Pharmacy, Tokyo, Japan
K. KurityvaMa—Kyoto Prefectural University of Medicine,
Kyoto, Japan
AIMS AND SCOPE
BIOCHEMICAL PHARMACOLOGY is an international journal which publishes research findings in pharmacology
deriving from investigations that employ the disciplines of biochemistry, biophysics, molecular biology, genetics,
structural biology, computer models and/or physiology. Reports of studies with intact animals, organs, cells,
subcellular components, enzymes or other cellular molecules and model systems are acceptable if they define
mechanisms of drug action. Descriptive mat/iematical models including those involving computer techniques are
also welcome. Experiments involving the use of drugs to elucidate physiological and behavioral mechanisms in
living organisms are also within the scope of the journal. In general, papers which record concentrations of drugs
and metabolites in body fluids will only be accepted if they contribute to an understanding of biochemical and
biophysical mechanisms. The Editors, however, reserve the right to publish any papers of major interest in the
field. Only contributions in English can be considered or published.
The journal publishes the following types of communication:
(1) Full-length Papers. These consist of a body of work presenting original findings relating to the question
proposed by the investigators undertaking the research.
(2) Short Communications. These consist of an original body of work of narrower scope but of the same quality
as the above. By definition, these papers are shorter than full-length manuscripts.
(3) Rapid Communications. These promote rapid dissemination of timely and significant observations within
the scope of the journal. Manuscripts must be submitted in English and will be judged as appropriate for
publica’ion as rapid communications on the basis of their immediate importance. They should be written to
emphasize clearly the novel aspects of the research. These criteria will be applied strictly. In order to speed up
the publication of rapid communications, authors are encouraged to use the special laysheets available from any
of the Regional Editors.
(4) Commentaries are short commissioned review articles (3000-5000 words in length). They are designed to
be editorial statements on selected topics, and should not be exhaustive reviews. Primarily, Commentaries are
intended to stimulate thought. They can be controversial, and can either focus on areas subject to much activity,
or draw attention to relatively neglected fieids in which there are both the opportunity and the need for research
in biochemical pharmacology. Particularly welcome will be Commentaries in which authors present their personal
view on the state of the subject on which they are reporting, and give their view as to where in the near or distant
future the subject may be moving. Authors are especially encouraged to take issue with popular dogmas. The
Commentary series is edited by Professor Harold R. Behrman.
In order to increase the exchange of information and ideas, the Journal will also publish Comments on a
Commentary, in which selected, highly qualified authorities are invited to offer their own observations on
Commentary articles, which will be published in the same issue of the Journal, and thus provide some alternative
thoughts on important areas of research. For further information see Biochem Pharmacol 31, 2568 (1982).
While the final decision on selection of authors for either Commentaries or Comments on a Commentary will
be made at the discretion of the editor, suggestions from readers will be welcome. These should be addressed
to: Professor H. R. Behrman, Department of Pharmacology, Yale University School of Medicine, 333 Cedar
Street, New Haven, Connecticut 06510.
(5) Meeting Reports. The journal is prepared to publish as preliminary communications short, factual two-page
summaries of selected papers from small meetings or conferences. The meetings should be those where attendance
is by invitation and all papers to be published will be refereed. Organizers who wish to have their meetings
published in this way should contact the appropriate Regionai Editor.
Notes for Contributors can be found in all issues and Abbreviations in issues 1 and 7
CONTENTS OF VOLUME 48
5 JULY 1994
Commentary
ANIL B. MUKHERJEE, LUCIO MIELE Phospholipase A, enzymes: regulation and physiological
and N. PATTABIRAMAN role
Rapid Communication
CHRISTIAN PERIGAUD, Equal inhibition of the replication of human immuno-
ANNE-MaRIE AUBERTIN, deficiency virus in human T-cell culture by ddA bis(SATE)
SAMIRA BENZARIA, HELENE PELICANO, phosphotriester and 3’-azido-2’,3’-dideoxythymidine
JEAN-Luc GIRARDET,
GEORGES Maury, GILLES GOSSELIN,
ANDRE KIRN and JeEAN-Louts IMBACH
Research Papers
D. LLoyps and M. B. HALLETT Neutrophil “priming” induced by orthovanadate:
evidence of a role for tyrosine phosphorylation
RutH L. McDonaLp, Davip F. Kaye, Bradykinin-evoked release of [’H]Jnoradrenaline from the
HELEN L. REEVE, STEPHEN G. BALL, human neuroblastoma SH-SYSY
Curis Peers and PETER F. T. VAUGHAN
A. HATZELMANN, R. FRUCHTMANN, Ca**+ ionophore A23187-stimulated secretion of azurophil
K.-H. Mours, S. RADDATZ granules in human polymorphonuclear leukocytes is
and R. MULLER-PEDDINGHAUS largely mediated by endogenously formed leukotriene B,
MARTIN KRAuPP, BARBARA PASKUTTI, Inhibtion of purine nucleobase transport in human
CLaup1IA SCHON and RICHARD MARZ erythrocytes and cell lines by papaverine. Investigation of
structure—activity relationship
DANIELE DOLLIs and FRANCIS SCHUBER Effects of a 2,3-oxidosqualene-lanosterol cyclase inhibitor,
2,3:22,23-dioxidosqualene and 24,25-epoxycholesterol
on the regulation of cholesterol biosynthesis in human
hepatoma cell line HepG2
JUKKA HAKKOLA, MARKKU PASANEN, Expression of xenobiotic-metabolizing cytochrome P450
RAUA PURKUNEN, SEPPO SAARIKOSKI, forms in human adult and fetal liver
OLAVI PELKONEN, JUKKA MAENPAA,
ANDERS RANE and HANNU RAUNIO
CHRISTIANE SCHEWE, TANKRED SCHEWE Strong inhibition of mammalian lipoxygenases by the
and ALBRECHT WENDEL antiinflammatory seleno-organic compound ebselen in the
absence of glutathione
CONCEPCION PEREZ, The action of the DNA intercalating agents 4’-(9-
LucreciA CAMPAYO, PILAR NAVARRO, acridinylamino) methanesulphon-m-anisidide and 1,4-
Laura GARCiA-BERMEJO bis(butylamino) benzo[g]phthalazine in U-937 human
and PATRICIO ALLER promonocytic cells: relationship between cell cycle and
differentiation
PrERRE SAVI, ARMELLE TROUSSARD Characterization of specific binding sites for [H]2-
and JEAN-MarRC HERBERT MeS-ADP on megakaryocytoblastic cell lines in culture
JosEPH A. NEAR, CHARLES E. ODYA Monoclonal antibodies reactive with a monoamine
and XIAOLIN LI transporter preparation purified from bovine adrenal
chromaffin granule membranes
Vv
vi List of Contents and Author Index for Volume 48, 1994
Mitsuo KITADA, TOSHIHARU Horie 93 Chemiluminescence associated with doxorubicin-induced
and SHon AWAZU lipid peroxidation in rat heart mitochondria
Bin-NAN Wu, TSONG-LONG HWANG, 101 Vaninolol: a new selective £,-adrenoceptor antagonist
CHING-FoNnG Liao and ING-JUN CHEN derived from vanillin
SANG GEON Kim, Ki Hwa JuNG, Differential expression of microsomal epoxide hydrolase
Won KyunG YANG and Nak Doo Kim gene by azole heterocycles in rats
Grecory A. FECHNER, Reduction of DNA _ synthesis, pigment synthesis,
JOANNA MICHEL, Rick A. STURM, pigmentation gene mRNA and resistance to UVB
JerF J. Jacops and PETER G. PARSONS in human melanoma ceils treated with analogues of a
histamine (H2) agonist
DANNY T. MUSKARDIN, Modulation of pulmonary leukotriene formation and
NorBeErT F. VOELKEL perfusion pressure by bestatin, an inhibitor of leukotriene
and F. A. FITZPATRICK A, hydrolase
MOHAMED Z. GaD The distribution of non-specific carboxylesterases and
glutathione S-transferases in different rat liver cells. Effect
of vitamin A deficiency
GLENN J. BuBLEY, BEVERLY A. TEICHER, Differences in in vivo and in vitro sequence-specific sites of
GeorGE K. OGaATA, cisplatin-DNA adduct formation and detection of a
LARUE S. SANDOVAL dose-response relationship
and TETSUYA KUSUMOTO
STEPHEN C. BONDY and SASSAN NADERI Contribution of hepatic cytochrome P450 systems to the
feneration of reactive oxygen species
LesTER M. BORNHEIM, Induction and genetic regulation of mouse hepatic
E. THOMAS EVERHART, JIANMIN LI cytochrome P450 by cannabidiol
and M. ALMIRA CORREIA
J. CHRISTOPHER GORSKI, Characterization of dextromethorphan N-demethylation
Davip R. Jones, STEVEN A. WRIGHTON by human liver microsomes. Contribution of the cyto-
and STEPHEN D. HALL chrome P450 3A (CYP3A) subfamily
GEOFFREY M. THIELE, Specificity of N-ethyl lysine of a monoclonal antibody to
Kirk M. WEGTER, acetaldehyde-modified proteins prepared under reducing
MICHAEL F. SorRRELL, DEAN J. TUMA, conditions
THomas L. MCDONALD
and LYNELL W. KLASSEN
ALFREDO J. MISLE, Methoctramine binding sites sensitive to alkylation on
ITALA Lippo DE BECEMBERG, muscarinic receptors from tracheal smooth muscle
RAMONA GONZALEZ DE ALFONZO
and MARCELO J. ALFGNZO
Short Communications
A. Davip RODRIGUES Comparison of levels of aldehyde oxidase with
cytochrome P450 activities in human liver in vitro
HiroyYuKI! IsHIZAKI and Inhibitory effect of the nonpeptide angiotensin II receptor
MASAKATSU OHTAWA antagonist losartan and its active metabolite, E-3174,
on cAMP phosphodiesterase: additional action of the
antagonists
T. SAKAGUCHI, N. SANDOH Enhanced gastric acid secretion induced by gastrin can be
and T. Aono suppressed by glucose injected into the portal vein in rats
Makoto Naol, WAKAKO MARUYAMA, Inhibition of tryptophan hydroxylase by dopamine and
TSUTOMU TAKAHASHI, Miyuki OTA the precursor amino acids
and HASAN PARVEZ
Announcemert
19 JULY 1994
Commentary
FUMIO MATSUMURA 215 How important is the protein phosphorylation pathway in
the toxic expression of dioxin-type chemicals?
List of Contents and Author Index for Volume 48, 1994
Rapid Communications
Z1YING ZANG, WOUTER FLORUN 225 Reduction in muscarinic receptors by antisense oligo-
and IAN CREESE deoxynucleotide
YuK-FuNG Hul, JosepH KOLars, 229 Intestinal clearance of H,-antagonists
ZHENZE Hu and DAvip FLEISHER
STEPHEN T. Davis, SUZANNE S. JOYNER, 5-Ethynyluracil (776C85): protection from 5-fluorouracil-
Davip P. BACCANARI induced neurotoxicity in dogs
and THOMAS SPECTOR
Research Papers
Et KASHTYAMA, TSUYOSHI YOKOI, Chiral inversion of drug: role of intestinal bacteria in the
TAKASHI TODAKA, MASAAKI ODOMI stereoselective sulphoxide reduction of flosequinan
and TETSUYA KAMATAKI
Marc WEIBEL, JAN BALZARINI, Potentiating effect of {2-[2-{(2-amino-1,6-dihydro-6-oxo-
ANNIE BERNHARDT 9H-purin-9-yl)methyl]-phenyl]Jethenyl}-phosphonic acid
and PIERRE MAMONT (MDL 74,428), a potent inhibitor of purine nucleoside
phosphorylase, on the antiretroviral activities of 2’,3’-
dideoxyinosine combined to ribavirin in mice
MARLENE JIMENEZ DEL RIO, Interaction of serotonin- and dopamine-related neuro-
CARLOS VELEZ PARDO, JEF PINXTEREN, toxins with “serotonin binding proteins” in bovine frontal
WERNER De Potter, Guy EBINGER and cortex
GEORGES VAUQUELIN
A. MATTANA, F. BENNARDINI, Cytotoxicity of lazaroid U-75412E in human epithelial cell
C. JULIANO, V. Picci, S. MARCEDDU, line (Wish)
L. Scio.a, P. PippiaA and F. FRANCONI
V. A. EaGLina, J. L. Howe, The metabolism of zidovudine by human liver microsomes
M. J. Barry and D. J. Back in vitro: formation of 3’-amino-3’-deoxythymidine
JULIE KirK, SAMIUDDIN K. SYED, Reversal of P-glycoprotein-mediated multidrug resistance
ADRIAN L. HARRIS, MICHAEL JARMAN, by pure anti-oestrogens and novel tamoxifen derivatives
Basiz D. ROUFOGALIS,
IAN J. STRATFORD
and JAMES CARMICHAEL
U. SUBRAHMANYESWARA Rao, Antiestrogens and steroid hormones: substrates of the
Roser L. Fine and human P-glycoprotein
GENE A. SCARBOROUGH
ARMELLE FOLIOT and PHILIPPE BEAUNE Effects of microsomal enzyme inducers on glutathione
S-transferase isoenzymes in livers of rats and hamsters
GERALDINE PRON, Involvement of membrane bleomycin-binding sites in
JEAN BELEHRADEK Jr, bleomycin cytotoxicity
STEPHANE ORLOWSKI
and Liuis M. Mir
WE! Qu, SREDERICK C. KAUFFMAN Food restriction and stimulation of monooxygenation of
and RONALD G. THURMAN p-nitroanisole in perfused rat liver
JOHN C. SCHMITZ, GERALD B. GRINDEY, Impact of dietary folic acid on reduced folates in mouse
RICHARD M. SCHULTZ plasma and tissues. Relationship to dideazatetrahydro-
and Davip G. PRIEST folate sensitivity
ZHAN-RONG Li, MING-BIAO YIN, Down-regulation of c-myc gene expression with induction
MarK A. ARREDONDO, of high molecular weight DNA _ fragments by
CHRISTOPH SCHOBER fluorodeoxyuridine
and Youcer M. RustuM
JosePH G. Cory, ANN H. Cory, Inhibitors of ribonucleotide reductase. Comparative
GERMANA RapPA, AURELIO LoRICo, effects of amino- and hydroxy-substituted pyridine-2-
Mao-Cuin Liv, Tal-SHUN Lin and carboxaldehyde thiosemicarbazones
ALAN C. SARTORELLI
BiaGio D1 Micco, GIOVANNI COLONNA, Rat protein SV-IV (seminal vesicle protein No. 4)
RAFFAELE PORTA accelerates human blood coagulation in vitro by selective
and SALVATORE METAFORA inhibition of antithrombin III
Vili List of Contents and Author Index for Volume 48, 1994
FeNG-NIEN Ko, 353 Inhibition of cyclooxygenase activity and increase in
Y1-SAN Lee, TIAN-SHUNG Wu platelet cyclic AMP by girinimbine. isolated from Murraya
and CHE-MING TENG euchrestifolia
CHRISTINE B. BREZDEN, Mechanism of the selective hypoxic cytotoxicity of
Rospert A. MCCLELLAND 1-methyl-2-nitroimidazole
and A. MICHAEL RAUTH
RAMANATH MAJUMDAR, Effects of calcium channel antagonists on the release of
JEFFREY T. NGUYEN and prostaglandin E, from metabolically stressed muscle
MICHAEL H. BROOKE
KAREN R. Gravitt, NANcy E. WarD, Evidence that protein kinase C-a activation is a critical
Dominic FAN, JOHN M. SKIBBER, event in phorbol ester-induced multiple drug resistance in
BERNARD LEVIN human colon cancer cells
and CATHERINE A. O'BRIAN
MINGXIN QIAN, ToT Bul, Metabolism of 3’-azido-3’-deoxythymidine (AZT) in
Ropney J. Y. Ho human placental trophoblasts and Hofbauer cells
and JASHVANT D. UNADKAT
MARGUERITE A. SOGNIER, YIN ZHANG, Sequestration of doxorubicin in vesicles in a multidrug-
RICHARD L. EBERLE, Kevin M. SWEET, resistant cell line (LZ-100)
GUILLERMO A. ALTENBERG
and James A. BELLI
MICHAEL J. KELNER, Characterization of illudin S sensitivity in DNA repair-
Trevor C. McMorais, Leita Estes, deficient Chinese hamster cells. Unusually high sensitivity
MARY RUTHERFORD, MARK MONTOYA, of ERCC2 and ERCC3 DNA helicase-deficient mutants in
Jit. GOLDSTEIN, KYRA SAMSON, comparison to other chemotherapeutic agents
Rosin STARR and RAYMOND TAETLE
JAMES M. SCHAEFFER, Nematocidal activity of MK-801 analogs and related
ALAN R. BERGSTROM, drugs. Structure—activity relationships
EASTER G. FRAZIER
and Dennis UNDERWOOD
Short Communications
T.-W. Wu, K.-P. Funa, L.-H. ZENG, Propyl gallate as a hepatoprotector in vitro and in vivo
J. Wu and H. NAKAMURA
A. RENGASAMY and R. A. JoHNsS Effect of hydrogen peroxide and catalase on rat cerebellum
nitric oxide synthase
YASUHIDE UssiMa, JUN-ICHI OsSHIDA, Inhibition of human sputum elastase by 7-substituted
HIROSHI KAWABATA, $-methy]-2-isopropylamino-4H -3,|-benzoxazin-4-ones
MASAYUK! Kokuso, YOSHINORI KATO
and KATSUHIKO Fusii
A. LALE and J. M. HERBERT Polyunsaturated fatty acids reduce pyrogen-induced tissue
factor expression in human monocytes
XIAOCHUN WU and Expression of the choroid plexus sodium-nucleoside
KATHLEEN M. GIACOMINI cotransporter (N3) in Xenopus laevis oocytes
JOHN M. BERTONI and Effects of in vitro ethanol on the brain cation pump in
PAMELA M. SPRENKLE alcoholics and controls
3 AUGUST 1994
Commentary
ANIL K. JAISWAL 439 Antioxidant response element
Research Papers
MiGuet Paya, Paut A. Goopwin, 445 Superoxide scavenging activity in leukocytes and absence
BEATRIZ DE LAS HERAS of cellular toxicity of a series of coumarins
and J. R. S. Hout
YASUYUK!I SADZUKA, Protection against cisplatin-induced nephrotoxicity in
YOSHIHIKO SHIMIZU, YOSHID TAKINO the rat by inducers and an inhibitor of glutathione
and Sapao HirRoTA S-transferase
List of Contents and Author Index for Volume 48, 1994 ix
FRANK N. A. M. VAN PELT 461 Formation of trifluoroacetylated protein antigens in
and J. GERALD KENNA cultured rat hepatocytes exposed to halothane in vitro
A. APLIN and S. WONNACOTT 473 Interaction of p-aminophenyldichloroarsine, an arsenical
with specificity for vicinal cysteines, with [’H]cytisine
binding sites in rat brain membranes
ARIANE BAZAN, ERIC VAN DE VELDE 479 Effect of age on B-receptors, G,,- and G,,-proteins in rat
and NORBERT FRAEYMAN heart
JoAo A. N. LARANJINHA, 487 Reactivity of dietary phenolic acids with peroxyl
LEONOR M. ALMEIDA radicals: antioxidant activity upon low density lipoprotein
and Vitor M. C. MADEIRA peroxidation
ANGuS BELL, BARBARA WERNLI and 495 Roles of peptidyl-prolyl cis—trans isomerase and
RICHARD M. FRANKLIN calcineurin in the mechanisms of antimalarial action of
cyclosporin A, FK506, and rapamycin
WENCESLAS K. AGBOTOUNOU, 505 Activation of the mitogen-activated protein kinase cascade
SIMONE MOUusSsET, SOPHIE PIPERNO, by tyrphostin (RG 50864)
MICHEL PIERRE,
ALAIN JACQUEMIN-SABLON
and JOSIANE PIERRE
PeTerR H. M. Hoer, 517 Putrescine and paraquat uptake in human lung slices and
CHRISTIAN P. L. Lewis, isolated type II pneumocytes
Maurits DEMEDTS
and BENoIT NEMERY
Mary K. RITKE, 525 Increased c-jun/AP-1 levels in etoposide-resistant human
VLADIMIR V. BERGOLTZ, leukemia K562 cells
WILLIAM P. ALLAN
and Jack C. YALOWICH
Maria Eiza J. Souza, 535 Effect of fluoxetine on rat liver mitochondria
ANA CRISTINA M. POLIZELLO,
SERGIO AKIRA UYEMURA,
ORLANDO CASTRO-SILVA JR
and CARLOS CURTI
STANTON L. GERSON, 543 Combined depletion of O°%-alkylguanine-DNA alkyl-
SOSAMMA J. BERGER, MARIE E. VARNES transferase and glutathione to modulate nitrosourea
and CHERYL DONOVAN resistance in breast cancer
J. Markovits, A. K. LARSEN, 549 Inhibition of DNA topoisomerases I and II and induction
E. SEGAL-BENDIRDJIAN, P. Fosse, of apoptosis by erbstatin and tyrphostin derivatives
J.-M. Saucier, A. Gazit, A. LEviTZKI,
K. UMEZAWA
and A. JACQUEMIN-SABLON
Gennapy P. ILyIN, 561 Human hepatocytes express trifluoroacetylated neo-
MARYVONNE RISSEL, antigens after in vitro exposure to halothane
YANNICK MALLEDANT,
MICHELE TANGUY and
ANDRE GUILLOUZO
YiNG-Z1 YANG, BRYAN LITTLE and 569 Alkylation of proteins by artemisinin. Effects of heme, pH,
STEVEN R. MESHNICK and drug structure
Rosert W. BYRNES 575 DNA strand breakage in isolated nuclei subjected to
and Davip H. PETERING bleomycin or hydrogen peroxide
Laura Giusti, LETIZIA TRINCAVELLI, 583 Characterization of peripheral-type benzodiazepine
CLAUDIA MARTINI binding sites from rat and pig pancreas
and ANTONIO LUCACCHINI
KELEM KASSAHUN, 587 Effect of carbamate thioester derivatives of methyl- and
CLaupIA M. JOCHHEIM 2-chloroethyl isocyanate on glutathione levels and
and THomas A. BAILLIE glutathione reductase activity in isolated rat hepatocytes
Mark R. FESEN, YVES POMMIER, 595 Inhibition of HIV-1 integrase by flavones, caffeic acid
FRANCOIS LETEURTRE, phenethyl ester (CAPE) and related compounds
SaTosH! HiROGUCHI, JESSIE YUNG
and Kurt W. KOHN
x List of Contents and Author Index for Volume 48, 1994
Short Communications
DesoraH L. TOPPMEYER, 609 Role of P-glycoprotein in dolastatin 10 resistance
CHRISTOPHER A. SLAPAK, JAMES CROOP
and DonaLp W. KuFE
A. Tupor Evans and SIMON L. Crort Antileishmanial actions of tricyclic neuroleptics appear to
lack structural specificity
LAKSHMAIAH SREERAMA Identification of the class-3 aldehyde dehydrogenases
and NorMaN E. SLADEK present in human MCF-7/0 breast adenocarcinoma cells
and norma! human breast tissue
S. N. WICKRAMASINGHE and R. HASAN In vivo effects of vitamin C on the cytotoxicity of post-
ethanol serum
17 AUGUST 1994
Commentary
TimoTHy D. WARNER, 625 Endothelin receptor antagonists: actions and rationale for
BRUNO BaTTISTINI, their development
ANNETTE M. DOHERTY
and ROGER CORDER
Research Papers
TAMiE NAKAJIMA, RuI-SHENG WANG, CYP2C11 and CYP2B1 are major cytochrome P450 forms
Ervor ELOVAARA, involved in styrene oxidation in liver and lung microsomes
FRANK J. GONZALEZ, from untreated rats, respectively
Harry V. GELBOIN, HARRI VAINIO
and TOsHIFUMI AOYAMA
LEONID N. GRINBERG, Protective effects of rutin against hemoglobin oxidation
EviEzER A. RACHMILEWITZ
and HAROLD NEWMARK
KEN-ICHI MasuDA, TETSUYA SuGA, Specific cleavage of secretory leukoprotease inhibitor by
AKIKO TAKEUCHI, neutrophil elastase and saliva
MASAHARU KANESAKI,
ATSUSHI IMAIZUMI and Yos! SUZUKI
WALTER h. J. WARD, PETER N. Cook, Epidermal growth factor receptor tyrosine kinase:
ANTHONY M. SLaTer, D. Huw Davies, investigation of catalytic mechanism, structure-based
GEOFFREY A. HOLDGATE searching and discovery of a potent inhibitor
and Lesuie R. GREEN
JOHN A. RING, HANY GHABRIAL, Hepatic uptake and excretion of ['*C]sodium taurocholate
MICHAEL S. CHING, SIMON POTOCNIK, by the isolated perfused fetal sheep liver
ARTHUR SHULKES,
RICHARD A. SMALLWOOD
and Denis J. MORGAN
RICHARD S. FERNANDES Apoptosis or necrosis: intracellular levels of glutathione
and Tizomas G. COTTER influence mode of cell death
CHARLES EL RAWADI, MONIQUE Davy, Biochemical characterization of the mechanisms involved
MICHELE MIDOL-MONNET in the 5-hydroxytryptamine-induced increase in rat atrial
and Yves COHEN rate
ANDREA HuUWILER, DoRIANO FABBRO Comparison of different tumour promoters and bryostatin
and JOSEF PFEILSCHIFTER 1 on protein kinase C activation and down-regulation in
rat renal mesangial cells
XING-MaAI JIANG, Pretranslational down-regulation of male specific hepatic
ELIZABETH CANTRILL, P450s after portal bypass
GEOFFREY C. FARRELL
and MICHAEL MuRRAY
N. MESTDAGH, B. VANDEWALLE, Comparative study of intracellular calcium and adenosine
L. Hornez and J.-P. HENICHART 3’, 5’-cyclic monophosphate levels in human breast
carcinoma cells sensitive or resistant to Adriamycin®:
contribution to reversion of chemoresistance