Biochemical Pharmacology 1993: Vol 45 Index

34 Pages·1993·12 MB·English

BIOCHEMICAL PHARMACOLOGY
SUBJECT INDEX FOR VOLUME 45, 1993
A23187
stimulated PMNs, effect of cloricrom- Aclarubicin analogs
ene on leukotriene production 123 interaction with topoisomerase II
Acetaldehyde 2025
induced formation of l-methyl-1,2,3, Acridine carboxamide
4-tetrahydro-S-carboline-3- aldehyde oxidase-mediated metabolism
carboxylic acid in rats 935 effect of SKF-525A 2159
Acetaldehyde-ethanol exchange Acyl CoA:cholesterol acyltransferase
in hepatocytes, effect of cyanamide, in liver, effect of butylated
methylene blue and penicillamine hydroxyanisole 513
553 Acy1l-CoA oxidase
4-Acetamido-4'-isothiocyanatostilbene- in liver
2,2'-disulfonic acid effect of sulphur-substituted
effect on lung surfactant secretion fatty acid analogs 257
1905 effect of thyroid state on
Acetaminophen induction by ciprofibrate 1437
mechanisms of hepatotoxicity 449 Acyl glucuronides
metabolism in hepatocytes, zonation reactivity 1043
1251 Adenosine
oxidation to N-acetyl-p-aminobenzo- inhibition of p-nitrophenol glucur-
quinone imine by human CYP3A4 1563 onidation in hepatocytes 1544
oxidative stress in cultured hepato- Adenosine diphosphate-ribosylation
cytes 2289 by Clostridium botulinum C3, effect
uptake and conjugation by isolated of sodium dodecyl sulfate 1409
liver cells 1599 Adenosine-3' ,5'-monophosphate
Acetone differential regulation of neutro-
induction of cytochrome P450 2E1 in phil responses 1613
hepatocytes 1483 in Euglena, cyclic GMP and circadian
N-Acetyl-p-aminobenzoquinone imine rhythmicity 2087
formation from acetaminophen 1563 5-HT1A receptor mediated inhibition
2-Acetylaminofluorene of adenylate cyclase 375
treated rats, tocotrienol effects on in LPS-stimulated macrophages,
glutathione-dependent enzymes in effect of phosphodiesterase
liver 1517 inhibitors 2399
Acetyl-L-carnitine PGIy induced formation in platelets,
effect on methyl-4-phenyl-1,2,3,6- effect of arachidonic acid 1815
tetrahydropyridine neurotoxicity role in calcium homeostasis 2279
2170 role in RNA synthesis in parotid
Acetylcholine gland 1395
lymph vessel tone 194] in SH-SY5SY neuroblastoma cells,
Acetylcholinesterase effect of isobutylmethylxanthine
in erythrocytes, effects of 3-carbamyl- and phosphodiesterase-selective
L-allylquinuclidinium bromide 465 inhibitors 2373
in quail embryo 87 Adenosine receptor-blocking xanthines
soman-inhibited, effect of soman inhibition of phosphodi2sterase
simulator on reactivation by HI-6 isozymes 84/7
499 (35S)Adenosine 5'-Q-(2-thiodiphosphate)
Acetyl-CoA hydrolase binding and intracellular calcium
in liver cytosol, effect of clofibrate response in liver parenchymal
1403 cells 801
N-Acetylcysteine Ca2+-Adenosine triphosphatase
effect on hyperoxic lung injury 841 in liver endoplasmic reticulum,
Acidosis effect of ciprofibrate on thiol
effect on propranolol clearance in integrity 2093
perfused liver 763 Na*,K -Adenosine triphosphatase
2 BIOCHEMICAL PHARMACOLOGY
Nat+,K+-Adenosine triphosphatase AIDS
in jejunum, effect of nordihydro- immune stimulation by anti-rev
guaiaretic acid 1932 oligomer 2037
in PCl12 cells, effect of ethanol Ajoene
1653 effects on Trypanosoma cruzi 2381
Adenosine triphosphate Aklavinone
binding to P2 purinoceptor in parotid containing anthracyclines, inter-
acinar cells 1936 action with topoisomerase II 2025
depletion in astroglial cells, degrad-Albumin, human serum
ation of membrane phospholipids drug binding 1/715
1149 naproxen coupled, hepatic targeting
S-Adenosylmethionine decarboxylase
in L1210 cells, stabilization by sebacic acid binding 69/7
aminoguanidine 1174 steroid binding 2411
in rat tissues, effect of inhibitors suprofen binding 1017
of aminopropyltransferases 1897 Alcohol dehydrogenase
Adenylyl cyclase gastric mucosa 1989
in brain, inhibition and kj-opioid Aldehyde dehydrogenase
receptors 207 cinnamic acid derivatives interact
in CHO cells, effect of rauwolscine with nucleotide binding site 1621
and yohimbine 2337 class 3 in breast tissue 2487
in ciliary processes, oxyanion in hepatocytes, effect of methylene
interactions 1311 blue 553
in Euglena, cyclic GMP and circadian in tumor and hematopoietic progenitor
rhythmicity 2087 cells, inhibition by chloral
in HeLa cells, negative coupling to hydrate 231
5-HT,jq receptors 375 in yeast, inhibition by nitroxyl
in olfactory bulb, muscarinic stim- analogs 2129
ulation 281 Aldehyde oxidase
Adhesion receptors, protein kinase C metabolism of acridine carboxamide,
and tumor cell adhesion 527 effect of SKF-525A 2159
Adipocytes Alkoxyresorufins
atypical B-adrenoceptors 974 metabolism in liver microsomes
Adipose tissue goat, induction 113
effect of retinoic acid on lipoprotein effect of tamoxifen 21
lipase and mRNA 5/79 06-Alkylguanine-DNA alkyltransferase
Adrenal gland in colon cancer cells, effect of
imidazoline receptors in medulla 06-benzylguanine and BCNU 483
1667 Allopurinol
mitochondrial benzodiazepine receptors transport in human erythrocytes 893
999 Alloxan diabetes
effect of substance P on catecholamine antioxidant status in rat liver,
biosynthesis in chromaffin cells effect of vanadate 539
1165 Alveolar type II cells
Adrenaline effect of stilbene disulfonates on
effect on hepatic lipid metabolism surfactant secretion 1905
2435 ad-Amanitin
stimulation of RNA synthesis in effect on cytochrome P450 2El mRNA
parotid gland 1395 levels in acetone-treated hepato-
Adrenergic antagonists cytes 1483
effect on hepatic lipid metabolism Amantadine
2435 effect on Plasmodium falciparum 1168
a-Adrenergic receptors Amicarbalide
in growth hormone-deficient rats 2223 inhibition of kidney diamine oxidase
p-Adrenergic receptors 1355
in adipocytes, atypical 9/74 3-Amino-1,2,4-benzotriazine-1,4-di-N-
in growth hormone-deficient rats 2223 oxide
in parotid gland, regulation of cytochrome P450 isoforms in reductive
RNA synthesis 1395 metabolism 1065
Adriamycin metabolism by purified DT diaphorase
cardiotoxicity, effect of tetrahydro- 321
neopterin 1953 5-Aminocarbony1-10,11-dihydro-5H-
cytotoxicity in HL-60 and HL-60/AMSA dibenzo(a,d)cyclohepten-5,10-
cells 516 imine 1547
ICRF-187 and toxicity of 1967 3'-Amino-3'-deoxythymidine-5'-mono-
Ageing phosphate
effect of interkeukin-1f8 on propran- inhibition of DNA polymerase-assoc-
olol enantioselective kinetics in iated 3' to 5' exonuclease 15/71
) 2-Amino-3,8-dimethylimidazo(4,5-f£)-
Ah receptor quinoxaline
binding to receptor binding factors metabolism in liver cell aggregates
in chromatin 1121 1087
indole carbinol binding 1129 Aminoglycoside
BIOCHEMICAL PHARMACOLOGY 3
Aminoglycoside Angiotensin II receptors(contd.)
nephrotoxicity, role of hepatic receptors on binding 2109
cytochrome P4500 780 Aniline hydroxylase
Aminoguanidine in hepatocytes, effect of acetone
stabilization of S-adenosylmethionine 1483
decarboxylase 11/74 in liver microsomes
Aminopeptidases A and B effect of Aroclor 1254 1373
in lung, effect of angiotensin- effect of interleukin 2 585
converting enzyme inhibition 1447 Anthracyclines
p-Aminophenol effect on DNA ligases I and II 1536
~ eytotoxicity in kidney cells, oxygen interaction with topoisomerase II
dependence 191 2025
N-(3-Aminopropyl )cyclohexylamine uptake and release by K562 cells
effect on polyamine synthesis in rat 1801
tissues 1897 Antidepressants
Aminopropyltransferase inhibitors antagonism of muscarinic receptors
effect on polyamine synthesis in rat in CHO-Kl1 cells 2352
tissues 1897 Antidiuretic hormone antagonists
4-Aminopyridine antidiuretic effects 1/731
ionotropic response in atria 1183 Antihistamines
5-Aminosalicylic acid antagonism of muscarinic receptors
oxidation products in vivo and in CHO-Kl cells 2352
in vitro 1201 Anti-inflammatory drugs
3-amino-1,2,4-triazole antagonism by superoxide 2003
effect on glutathione S-transferase effect on CINC production by
in ischaemia/reperfused liver 37 cytokine-stimulated kidney
Amiodarone fibroblasts 1425
accumulation in cultured human cells hepatic targeting 1215
349 Antimycin
Amitriptyline effect on uptake of organic cations
antagonism of muscarinic receptors in liver 809
on CHO-KI cells 2352 Antioxidant enzymes
Amlodipine in lung of Zucker rat, effect of
membrane interactions, effect of glucocorticoids 543
cholesterol 2173 Antioxidants
Ammonia flavonoids 13
in brain and liver of hyperammonemic lazaroids 241
mice, effect of sodium benzoate monohydroxamates 357
137 $5682 1531
Amphotericin B U-78517F 1477
effect on NADPH oxidase in a PMN Antioxidant status
cell-free system 766 diabetic rat liver 539
Amylase Antipyrine
in parotid gland, adrenergic regulat- metabolism in rats in vivo, effect
ion 1395 of malaria and fever 1243
Amylin Antisense oligomer
stimulated insulin secretion, effect rev gene of HIV-1l, immune stimulation
of calcitonin gene-related peptide by 2037
8-37 fragment 2343 Aorta
Anaesthetics, volatile angiotensin I degradation in
effect on calcium mobilization in endothelium and smooth muscle
endothelial cells 1137 1524
Anaphylactic bronchoconstriction 791 fibroblast growth factor-dependent
Anaphylatoxin C5a hypoxanthine metabolism in
synthetic receptor agonists 1289 endothelial cells 1695
Angiotensin I glyceryl trinitrate metabolism by
degradation in aortic endothelium cytochrome P450 268
and smooth muscle 1524 relaxation induced by N-nitroso
Angiotensin II compounds 819
induced increase in Ca2+ in NIE-115 Aphidicolin
cells, effect of B-phorbol-12,13- effect on DNA degradation in
dibutyrate 611 splenocytes 331
Angiotensin-converting enzyme effect on platinum drug sensitivity
bradykinin degradation in semen 1987 in L1210 cells 253
in lung, inhibition by idrapril 1358 1-8-D-Arabinofuranosylcytosine
proteolytic activity in tissues induction of jun-D expression 2055
following inhibition of 1447 Arachidonic acid
secretion by aortic rings, effect of effect on calcium transport in
protease inhibitors 144/7 liver nuclei 14/71
Angiotensinogen induced calcium release from
interleukin-6 induced synthesis 201 sarcoplasmic reticulum 1301
Angiotensin II receptors induced platelet aggregation, effect
in brain, effect of peptidase of prenylflavonoids 509
4 BIOCHEMICAL PHARMACOLOGY
Arachidonic acid(contd.) Bacitracin(contd. )
metabolism and release in PMNs, binding 2109
effect of cloricromene 123 Basic triphenylmethane dyes
reduction of PGI2-induced cyclic AMP inhibition of glutathione S-transfer-
formation 1815 ase in liver 1227
Argatroban Basophils
effect on IP response to «-thrombin effect of okadaic acid on secretion
1577 2311
Aroclor 1254 BAY K8644
induction of cytochrome P450 4A iso- effect on heart mitochondrial membrane
enzymes of lactating mothers and potential 1995
offspring 769 BAY X 1005
transplacental transfer 1373 inhibition of 5-lipoxygenase 101
Aromatic L-amino acid decarboxylase BCH-189
in kidney, effect of dietary effinity for human 2'-deoxycytidine
sodium 1791 kinase 1540
in portal vein, inhibition by 3-hyd- Bed nucleus of stria terminalis
roxybenzylhydrazine 1363 cholecystokinin in 2283
Arrhythmias Benzene
reperfusion induced, role of free metabolism in liver, species differ-
radicals 961 ences in cytochrome P450 isozymes
Artery 1079
effect of methylene blue on relaxat- Benzocaine
ion 367 effect on hypochlorous acid production
nitroglycerin-induced relaxation and by myeloperoxidase in neutrophils
nitric oxide production 15/7 2003
Artomunoxanthone Benzodiazepine receptors
antiplatelet activity 509 adrenal mitochondria, effect of
Arylamine N-acetyltransferases dopamine agonists and antagonists
sulfamethoxazole metabolism 1277 999
Arylesterase Benzo(a)pyrene hydroxylase
in liver and blood, paraoxon hydroly- in liver microsomes, effect of musk
sis 21 xylene 1659
Arylhydrocarbon hydroxylase 7-Benzoxyresorufin O-dealkylase
in human fetal tissues 899 in human brain 64/7
in liver microsomes, maternal and in liver microsomes, induction by
fetal rat, effect of Aroclor 1254 phenobarbital in male and female
1373 rats 521
Acetylsalicylic acid Benzphetamine N-demethylase
effect on blood cell membranes 1343 in liver microsomes
Asthma effect of interleukin-2 585
animal models 791 effect of picrotoxin 1783
Astrocytoma effect of rociverine 1097
early response gene induction 16/77 5-Benzylacyclouridine
Astroglial cells UC-11MG species differences in biochemical
phospholipase activation and cell effects and metabolism 173
injury 1149 06-Benzylguanine
Atenolol effect on nitrosourea resistance in
partition into brush border membrane colon cancer 483
liposomes 1775 Bepridil
Atherogenesis effect on heart mitochondrial
effect of thyronines 753 membrane potential 1995
Azatoxin Bergapten
cytotoxicity and inhibition of inhibition of coumarin 7-hydroxylase
topoisomerase II and tubulin 1035
polymerization 2449 Bestatin
Azidodansylrhizoxin renal transport 1/763
photoaffinity labelling of tubulin uptake in Xenopus oocytes injected
1387 with CaCo-2 cell poly(A)*RNA 776
3'-Azido-3'-deoxythymidine-5'-mono- Betamethasone
phosphate effect on carboxylesterases in liver
inhibition of DNA polymerase-assoc- microsomes 2317
iated 3' to 5' exonuclease 1571 Bile
3'-Azido-2' ,2'-dideoxy-5-bromouridine excretion of thyroid hormone glucur-
metabolism and mechanism of action onides, effect of hexachloro-
223 benzene 62/7
3'-Azido-2' ,3'-dideoxy-5-iodouridine effect of niacin and diosgenin on
metabolism and mechanism of action lipid output 43
223 Bile acids
effect on calcium in hepatocytes 289
Bile acid transporters
Bacitracin effect of EMD 56133 on uptake 917
effect on angiotensin II receptor Biphenyl
BIOCHEMICAL PHARMACOLOGY
Biphenyl Breast cancer cells MCF-7(contd.)
cytotoxicity in hepatocytes 1959 class 3 aldehyde dehydrogenase in
Birds 2487
butyrylcholinesterase in serum 991 N-1-leucyldoxorubicin pharmacology
cholinesterases in embryos 8/7 1929
1,10-Bis-(carboxymethylthio)decane measurement of ICI D1694 poly-
effect on hepatic antioxidant status glutamate metabolites in 863
and lipid peroxidation 257 effect of terfenadine 401
1,3-Bis(2-chloroethyl )-1l-nitrosourea Brofaromine
resistance in colon cancer 483 effect on acid metabolites of
Bistratene A amines in striatum 1317
properties and mode of action 1753 4-Bromoacetamidobenzoylcholiiondei-de
Bleomycin cholinergic receptor binding in
chromosome damage in parotid mammalian brain 2143
cells 569 Bromobenzene permercapturic acids
Blood formation of phenol and thiocatechol
oxidative systems, effect of rooperol metabolites through C-S lyase
and nordihydroguaiaretic acid 303 2513
xenobiotic metabolizing esterases in Bromocriptine
31 effect on mitochondrial benzodiazep-
Blood flow ine receptors 999
effect of pentoxifylline on acetamino- p-Bromophenacyl bromide
phen hepatotoxicity 449 inhibition of phospholipase A2 from
Blood pressure herniated disc 783
adrenoceptor-mediated responses in Bronchial hyperreactivity
growth hormone-deficient rats 2223 animal models 791
Blood vessels Brown adipose tissue
G proteins in function and dysfunction effect of metformin on energy
2365 expenditure 9/71
BMS 180,742 Brush border membrane vesicles
effect on IP response to “-thrombin bestatin transport 1/763
1577 partition of drugs 1/775
BMY 25067 and 25282 Bufotenine
mechanisms of cytotoxicity 2303 inhibition of cyclic AMP formation
Boron compounds in HA7 cells 375
intracellular distribution 147 Bufuralol monooxygenase
Bradykinin in liver microsomes, effect of
calcium mobilization in endothelial interleukin-2 585
cells, effect of halothane and Buspirone
isoflurane 1137 inhibition of cyclic AMP formation
calcium response in NIE-115 cells, in HA7 cells 375
effect of B-phorbol-12,13-dibutyr- Buthionine sulfoximine
ate 611 effect on activation of heat shock
degradation in semen 1983 transcription factors by Al2-PGJ,
lymph vessel tone 1941] 2457
effect on phospholipase D in tracheal effect on platinum drug sensitivity
smooth muscle 593 in L1210 cells 253
(1-5)Bradykinin Butylated hydroxyanisole
enzyme immunoassay 559 elevation of serum cholesterol 513
Brain t-Butylhydroperoxide
angiotensin II receptors 2109 cytotoxicity in kidney cells,
cholinergic affinity ligands 2143 oxygen dependence 191
cytochrome P450 in 647 effect on intestinal thiol status
6-fluoro-DL-tryptophan metabolism in 2011
1049 ¥-Butyrolactone
iron chelator Ll and monoamine fluorinated derivative, quantitation
metabolism 2411 using 19F-NMR 949
iron-initiated oxidative injury 1477 Butyrylcholinesterase
effect of lead on G proteins in pigeon serum, purification and
neurons 1107 immunological characterization
MK801 binding 605 991
organophosphate polyneuropathy in prophylactic antidote for nerve
chicks 131 agent toxicity 2465
pyrethroid stimulation of protein BW A4C
kinase C pathway 703 5-lipoxygenase inhibition 978
theophylline binding to membranes, BW-501
effect of §-9-tetrahydrocannabinol inhibition of cyclic AMP formation
1725 in HA7 cells 375
“%-tocopherol oxidation 2295
effect of valproate on lipogenesis
1283 C3 exoenzyme
Breast cancer cells MCF-7 Clostridium botulinum, effect of
effect of bistratene A 1753 sodium dodecyl sulfate on ADP-
6 BIOCHEMICAL PHARMACOLOGY
C3 exoenzyme(contd. ) Cannabidiol (contd. )
ADP-ribosylation 1409 1323
C5a receptor agonists Captopril
pharmacology, metabolism and in vivo effect on proteolytic activity in
cardiovascular effects 1289 rat tissues 1447
Caffeine Carbachol
effect on calcium in pancreatic B stimulation of phosphoinositide
cell 7 hydrolysis in olfactory bulb 281
effect on platinum drug sensitivity Carbamazepine
in L1210 cells 253 metabolism by activated neutrophils
Calcitonin gene-related peptide 1267
effect on insulin secretion 2343 3-Carbamy1l-N-allylquinuclidinium
Calcium bromide
arachidonic acid-induced release from effect on cholinergic activity and
sarcoplasmic reticulum 1301 soman intoxication 465
efflux in perfused liver, effect of Carbaryl
eicosanoids 2209 hydrolysis by rat liver, lung, skin
in hepatocytes and blood 31
effect of bile acids 289 Carbon tetrachloride
thapsigargin-stimulated inflow hepatotoxicity, effect of tetra-
2163 hydroneopterin 1953
in HeLa cells, role in action of phosphatidylinositol breakdown in
ether lipids 77 kidney cortical slices 1947
homeostasis in platelets, effect of Carbonylcyanide-m-chlorophenyl-
cyclic AMP phosphodiesterase IIIAl hydrazone
inhibitors 2279 effect on uptake of organic cations
influx in chromaffin cells, effect of in liver 809
substance P 1165 Carbonyl reductase
in liver parenchymal cells, effect in human liver, interindividual
of ADPp2°S_ 801 variability 1711
mobilization in endothelial cells, Carboxylesterases
effect of volatile anaesthetics in liver microsomes, induction by
1137 Synthetic steroids 2317
myocardial reperfusion injury 1333 in liver, lung, skin and blood,
in NIE-115 cells, effect of p-phorbol- xenobiotic metabolism 21
12, 13-dibutyrate on agonist- Cardiovascular system
induced increases 611 G proteins in function and dys-
in pancrearic B cell, role in Nat/Ca2t+ function 2365
exchange /7 Carnitine acetyltransferase
release from liver mitochondria, in liver, effect of thyroid status
effect of cyclosporin A and on induction by ciprofibrate 1437
related compounds 641 Carnitine acyltransferase
reoxygenation of hypoxic kidney in liver, inhibition by diethylhexyl-
cortical slices 1947 phthalate metabolite 827
role in 1,2-dichlorovinyl-cysteine Carrageenans
induced mitochondrial damage 2259 induced pleuricy, role of bradykinin
role in Hg(II)-induced oxidative 559
stress in kidney mitochondria 2017 inhibition of fibroblast growth
in synaptoneurosomes, neurotrans- factor receptor binding 2348
mitter release 407 Catalase
synaptosomal influx, effects of in hydrogen peroxide resistant
w-CgTx, neomycin and potassium 165 CHO cells 2251
in synaptosomes, effect of delta- effect on hydroxyl radical production
methrin 703 in ischaemic/reperfused heart 961
transport in liver nuclei in liver
effect of arachidonic acid 1471 diabetic rat, effect of vanadate
effect of zinc and copper 943 539
Calcium channels effect of sulfur-substituted fatty
voltage-sensitive, role in mediated acid analogs 257
evoked neurotransmitter release Catechin
165 antioxidant and iron-chelating
Calcium channel antagonists activity in hepatocytes 13
effect on heart mitochondrial suppression of active oxygen-induced
membrane potential 1995 cytotoxicity 265
membrane interaction, effect of Catecholamines
cholesterol 2173 biosynthesis in chromaffin cells,
effect on myocardial reperfusion effect of substance P 1165
injury 1333 Catechol-O-methyltransferase
Camptothecin in brain, effect of iron chelator Ll
resistant P388 leukemia cells 339 2411
effect on splenocytes 331 inhibition by l-vinyl derivatives of
Cannabidiol —, and nitroguaiacols
mediated cytochrome P450 inactivation
BIOCHEMICAL PHARMACOLOGY
Catechols 1-Chloro-2,4-dinitrobenzene
effect on human blood oxidative inhibition of nitroglycerin-induced
systems 303 vascular relaxation 157
Cations Chloroquine
uptake in liver, effect of metabolic lipid interactions 183
inhibitors 809 Chloroquine/amantidine
Cell culture effect on Plasmodium falciparum 1168
xenobiotic metabolism in aggregating Chlorpromazine
liver cells 1087 induced hemolysis, inhibition by
Cephadrine cyclodextrin sulfate 1011
transport in kidney, effect of Cholate
bestatin 1/763 uptake into hepatocytes, effect of
c-fos EMD 56133 917
expression in astrocytoma cells 1677 Cholecystokinin
CGP 12177 in bed nucleus of stria terminalis
stimulation of atypical B-adreno- 2283
ceptors in adipocytes 9/74 Cholestasis
CGP 20712 role of calcium 289
effect on CGP 12177 or isoproterenol Cholesterol
induced lipolysis in adipocytes biliary output, effect of niacin 43
974 esterification in macrophages,
CGP 37849 1547 effect of cyclandelate 1829
CGS 12970 modulation of membrane interaction of
effect on cyclosporin A nephrotoxicity calcium channel antagonists 2173
1351 in serum
CGS 19755 1547 elevation by butylated hydroxy-
Channel catfish anisole 513
liver monooxygenases 217 effect of niacin 43
c-Ha-ras synthesis in Hep G2 cells, effect
expression in maternal and fetal rat, of vestatins 2203
effect of Aroclor 1254 1373 Cholesteryl esters
Chemotaxis synthesis in liver, effect of
neutrophils, effect of cyclic AMP adrenergic antagonists 2435
1615 Cholinergic affinity ligands 2143
Chemotherapy Cholinesterases
circadian rhythms 667 effect of 3-carbamyl-L-allylquin-
Chenodeoxycholate uclidinium bromide 465
effect on calcium in hepatocytes 289 in Japanese quail embryo 87
Chicks Chromaffin cells
organophosphate polyneuropathy 131 imidazoline receptors 1667
Chinese hamster lung fibroblasts V79 effect of substance P on catechol-
expressing rat liver cytochrome P450 amine biosynthesis 1165
1A2, phenacetin metabolism in 1171Chromanoxyl radicals
suppression of active oxygen-induced stobadine interaction 393
cytotoxicity by flavonoids 265 Chromatin
Chinese hamster ovary cells Ah receptor binding 1121
antagonism of muscarinic receptors by Chromosomes
antidepressants and antihistamines bleomycin-induced damage in parotid
2352 cells 569
bleomycin damage to chromosomes 569 Ciliary processes
5-HT}, receptors 1003 adenylyl cyclase interaction with
hydrogen peroxide resistant catalase oxyanions 1311
in 2251 Cimetidine
Chloral hydrate anti-oxidant properties 2389
inhibition of aldehyde dehydrogenases Cinnamic acid derivatives
231 interaction with nucleotide binding
Chlorambucil site of aldehyde dehydrogenase
effect on glutathione S-transferase 1621
in Walker 256 mammary carcinoma Cinnarizine
cells 683 effect on heart mitochondrial
Chloramine membrane potential 1995
effect on formate-metabolizing Ciprofibrate
system 1059 alteration of endoplasmic reticulum
Chloricromene Ca2+-ATPase thiol integrity 2093
effect on arachidonate release and induction of peroxisomal enzymes in
metabolism in PMNs 123 liver, role of thyroid state 1437
Chloride Circadian rhythm
agonist-stimulated efflux from human cyclic GMP mediation 2087
neutrophils 1743 pyrimidine metabolizing enzymes in
p-Chlornaltrexamine liver 667
effect on k}-opioid receptor binding spleen cytoplasmic thymidine kinase
and inhibition of adenylyl cyclase 1115
207 Cisplatin
8 BIOCHEMICAL PHARMACOLOGY
Cisplatin Cyanamide
early response gene induction 16/77 effect on ethanol metabolism in
effect on microsomal ifosphamide hepatocytes 553
activation 1685 induced tetrahydro-j-carboline
modulation of cytotoxicity by formation 935
digitonin in vitro 2079 a-Cyano-3,4-dihydroxythiocinnamamide
oxidative damage to kidney mitochon- inhibition of mitochondrial
dria 2215 aldehyde dehydrogenase 1621
resistance in L1210 cells 253 “«-Cyano-3,4,5-trihydroxycinnamonitrile
resistant cells, keratin K14 reduction inhibition of mitochondrial
1703 aldehyde dehydrogenase 1621
e- jun
Cyclandelate
expression in astrocytoma cells 16/77 inhibition of cholesterol esterific-
expression in keratinocytes, effect ation in macrophages 1829
of ethanol 6/75 Cyclic nucleotide phosphodiesterases
Clofibric acid effect of adenosine receptor-blocking
effect on acetyl-CoA hydrolase in xanthines 847
liver cytosol 1403 in Euglena, cyclic GMP and circadian
induction of cytochrome P450 and rhythmicity 2087
peroxisomal enzymes in vivo and Cyclic nucleotide phosphodiesterase
in vitro 2045 inhibitors
Clorgyline effect on cyclic AMP levels in
effect on acid metabolites of amines SH-SY5Y neuroblastoma cells 2373
in striatum 1317 effect on platelet Ca2+ homeostasis
Clostridium botulinum 2279
effect of sodium dodecyl sulfate on protection against septic shock 2399
C-3 catalysed ADP-ribosylation Cyclocommunin
1409 effect on platelet aggregation 509
Cobalt protoporphyrin Cyclocommunol
effect on gentamicin nephrotoxicity effect on platelet aggregation 509
780 Cyclodextrin polysulfate
Colchicine protection of erythrocytes against
binding to tubulin, effect of hemolysis 1011
dolastatin 10 analogues 1503 Cyclomorusin
Collagen effect on platelet aggregation 509
induced platelet aggregation, effect Cyclomulberrin
of prenyl flavonoids 509 effect on platelet aggregation 509
Colon cancer cells Cyclo-oxygenase
effect of azatoxin 2449 in platelets, inhibition by rooperol
BCNU resistance 483 and nordihydroguaiaretic acid 303
diarylsulfonylurea cytotoxicity 2135 Cyclopentenyl cytosine
effect of eicosapentaenoic acid 2189 resistance in MOLT-4 lymphoblasts
Ht+/dipeptide cotransporter, express- 1493
ion in Xenopus oocytes /7/76 Cyclophilin
measurement of ICI D1694 polyglut- effect on mitochondrial calcium
amate metabolites in 863 release 641
effect of thiacarbocyanine dyes 691 Cyclophosphamide
Compactin analogs cytochrome P450-catalysed metabolism
effect on cholesterol synthesis in 1685
Hep G2 cells 2203 Cyclosporin A
w-Conotoxin GVIA effect on mitochondrial calcium
inhibition of noradrenaline release release 641
from brain, effect of potassium reversal of nephrotoxicity by
165 thromboxane synthetase inhibition
Copper 1351
effect on calcium transport in liver Cysteine
nuclei 943 in lung, effect of cysteine esters
oxidizability of human LDL 2195 1605, 1769
Coumarin 7-hydroxylase Cysteine esters
in liver microsomes, inhibition 1035 effect on thiol levels in rat lung
CP 93129 1605, 1769
inhibition of cyclic AMP formation Cytidine deaminase
in HA7 cells 375 in human placenta, 2',2'-difluoro-
c-raf deoxycytidine kinetics 1857
expression in maternal and fetal rat, Cytochrome b5
effect of Aroclor 1254 1373 in co-cultured hepatocytes 1583
Creatine kinase in liver microsomes, effect of
myocardial release, effect of dihydro- interleukin-2 585
pyridines 1333 Cytochrome P450
C-S lyase in aorta microsomes, glyceryl tri-
formation of phenol and thiocatechol nitrate biotransformation 268
metabolites from bromobenzene in brain, subcellular distribution
premercapturic acids 2513 647
BIOCHEMICAL PHARMACOLOGY
Cytochrome P450(contd. ) Cytochrome P450 2El
in fetal tissues, human 899 in hepatocytes(contd. )
in hepatocytes, dibromoalkane cyto- zonation of acetaminophen
toxicity 439 toxicity 1251
in kidney, effect of fasting and Cytochrome P450 3A
ether 871 in liver microsomes, human, vindesine
in liver microsomes biotransformation 853
cannabidiol-mediated inactivation spectrophotometric quantitation of
1323 isozymes 2239
channel catfish 217 Cytochrome P450 3Al
diabetes-induced changes, sex in liver microsomes, effect of
differences 313 tamoxifen 21
diazepam metabolism 59 Cytochrome P450 3A2
effects of fasting and ether 871 in liver microsomes, diazepam
fetal rat, effect of transplacen- metabolism 59
tal transfer of PCBs on isoenzymes Cytochrome P450 3A4
1373 acetaminophen oxidation 1563
goats, induction 113 Cytochrome P450 4A
ifosphamide activation 1685 in hepatocytes, effect of clofibric
induction by dietary indoles 1127 acid in vivo and in vitro 2045
induction by picrotoxin 1783 Cytochrome P450 4Al
effect of inflammatory mediators in liver microsomes, induction by
in vivo 415 lactational transfer of PCBs 769
effect of interleukin 2 585 Cytochrome P450 reductase
isoforma in SR4233 metabolism 1065 in co-cultured hepatocytes 1583
effect of malaria and fever 1243 Cytokine-induced neutrophil chemo-
nicotine metabolism 2554 attractant
effect of rociverine 1097 production by kidney fibroblasts
role in gentamicin nephrotoxicity 1425
780 Cytokines
species differences in isozymes induced tumor cell adhesion, role
1079 of protein kinase C 527
Cytochrome P450 1Al role in airway inflammation and
in liver microsomes, effect of bronchial hyperreactivity 791
interleukin-lB 2269 Cytoprotection
Cytochrome P450 1A2 flavonoids 13
in liver microsomes
effect of fluvoxamine 1211
effect of malaria and fever 1236 Dapsone
effect of musk xylene 1659 effect on hypochlorous acid product-
Cytochrome P450 2a-5 ion by myeloperoxidase in
in liver microsomes, coumarin neutrophils 2003
7-hydroxylase 1035 Dapsone hydroxylamine
Cytochrome P450 2A6 reduction to dapsone during methemo-
in liver microsomes, coumarin globin formation in erythrocytes
7-hydroxylase 1035 1027
Cytochrome 2B 3-Deazaadenosine
expression in co-cultured hepatocytes early response gene induction 1677
1583 Debrisoquine monooxygenase
in liver microsomes in liver microsomes, effect of
induction by phenobarbital in male interleukin-2 585
and female F344/NCr rat 521 Deer mice
induction by picrotoxin 1/783 alcohol dehydrogenase in gastric
effect of interleukin-lB 2269 mucosa 1989
rociverine metabolism 1097 Deltamethrin
spectrophotometric quantitation activation of phosphoinositide/
2239 protein kinase C pathway in
effect of tamoxifen 21 brain 703
Cytochrome P450 2B1/2 genes Deoxycytidine kinase
in hepatocytes, regulation of organo- HL-60 cells, 2',2'-difluorodeoxy-
sulfur compounds 2323 cytidine kinetics 1857
Cytochrome P450 2Cl1l MOLT-4 cells, affinity of oxathiol-
in liver microsomes, diazepam ane cytosine nucleosides 1540
metabolism 59 Deprenyl
Cytochrome P450 2C12 mRNA effect on acid metabolites of
in liver, effect of endotoxin amines in striatum 1317
Cytochrome P450 2D 1-Desamino-8-D-arginine vasopressin
in liver microsomes antidiuretic effects 1/731
diazepam metabolism 59 Desferrioxamine
induction by interleukin-2 free radical scavenging 35/7
Cytochrome P450 2El effect on malaria haemozoin 1431
in hepatocytes Deve lopment
induction by acetone 1483 glucocorticoid effects in Zucker
10 BIOCHEMICAL PHARMACOLOGY
Development (contd. ) cis-Dichloro-bis-isopropylamine-trans-
rat lung 543 dihydroxyplatinum LV
organophosphate polyneuropathy in resistance in L1210 cells 253
chicks 131 Dichloro(ethylenediammine)platinum II
Dexamethasone uptake by ovarian carcinoma cells,
effect on CINC production by cytokine- effect of digitonin 2079
stimulated kidney fibroblasts 2,2-Dichlorovinyl dibutyl phosphate
1425 effect on chicks 131
cytotoxicity toward L5178Y cells, 1,2-Dichlorovinyl-cysteine
effect of polyunsaturated fatty induced kidney mitochondrial damage,
acids 1881 role of calcium 2259
effect on drug metabolizing enzymes Dichlorphos
in liver 2269 effect on embryonic development 87
inducible gene expression in liver, Diclofenac
effect of dimethylnitrosamine effect on hypochlorous acid product-
1465 ion by myeloperoxidase in
induction of carboxylesterase in neutrophils 2003
liver microsomes 2317 Dicoumarol
modulation of ifosphamide metabolism effect on SR 4233 metabolism in
1685 Walker and JBl cells 321
effect on peptic activity of gastric 2',3'-Dideoxy-5-fluoro-3'-thiacytidine
lumen and mucosa 8/79 affinity for human 2'-deoxycytidine
Dexamethorphan kinase 1540
oxidative metabolism in rat liver 2',3'-Dideoxy-3'-thiacytidine
microsomes 833 affinity for human 2'-deoxycytidine
Diabetes kinase 1540
antioxidant status in liver, effect Dietary restriction
of vanadate 539 effect on monocrotaline-induced
induced changes in hepatic cytochrome pulmonary hypertension 2475
P450s, sex differences 313 Diethyldithiocarbamate
effect of metformin on energy effect on cytochrome P450 2Bl/2 mRNA
expenditure of brown fat 971 in hepatocytes 2323
Diacylglycerol Diethylhexylphthalate metabolite
induced perturbation of phospholipid inhibition of carnitine acyltrans-
membranes, effect of chloroquine ferase in liver 827
183 Diethylmaleate
Diallyl-G effect on conversion of xanthine
inhibition of GTPase in brain 2405 dehydrogenase to oxidase in liver
Diallyl sulfide 2359
regulation of cytochrome P450 2B1/2 Diflunisal
genes in hepatocytes 2323 covalent binding to rat tissues
Diamidines 1043
inhibition of kidney diamine oxidase 2',2'-Difluorodeoxycytidine
1355 kinetics with human deoxycytidine
Diamine oxidase kinase and cytidine deaminase
in kidney, inhibition by aromatic 1857
diamidines 1355 a&-(1,1-Difluoroethyl)-«-methyl-y¥ -
cis-Diamminedichloroplatinum(I1) butyrolactone
early response gene induction 16/77 19F-NMR study in brain 949
effect on mitochondrial ifosphamide Digitonin
activation 1685 modulation of cisplatin cytotoxicity
modulation of cytotoxicity by in vitro 2079
digitonin in vitro 20/79 Dihydroepiandrosterone
oxidative damage to kidney mitochond- protection of tracheal epithelial
ria 2215 cells from paraquat toxicity 1143
resistance in L1210 cells 253 Dihydroisocycloartomunin
resistant cells, keratin reduction effect on platelet aggregation 509
1703 Dihydropyridines
Diarylsulfonylureas attenuation of myocardial reperfusion
cytotoxicity 2135 injury 1333
Diazepam Dihydrouracil dehydrogenase
liver microsomal cytochrome P450 in liver, circadian rhythm 667
enzymes involved in metabolism 59 3,4-Dihydroxyphenylacetic acid
Diazepinone riboside in striatum, effect of MAO inhibitors
inhibition of cytidine deaminase 1857 1317
Dibromoalkane 1,25-Dihydroxyvitamin D3
toxicity in hepatocytes 439 fluorines on side chain of 2331
Dibromopropamide 3,3'-Diindolylmethane
inhibition of kidney diamine oxidase effect on estradiol hydroxylation
1355 in liver 1129
2,5-Di(tert-butyl )hydroquinone Diisopropyl phosphorofluoridate
effect on Ca2+ efflux in perfused effect on chicks 131
liver 2209 4,4'-Diisothiocyanatostilbene-2,2'-