Biochemical Pharmacology 1991: Vol 42 Table of Contents

33 Pages·1991·6.1 MB·English

BIOCHEMICAL
PHARMACOLOGY
AN INTERNATIONAL JOURNAL
(FOUNDED BY SIR RUDOLPH A. PETERS)
VOLUME 42, 1991
VOLUME CONTENTS AND AUTHOR INDEX
©
PERGAMON PRESS
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BIOCHEMICAL PHARMACOLOGY
EDITORIAL BOARD
Chairman: A. D. WELCH
Regional Editors
European Continent
Prof. PETER ALEXANDER Biochemical Pharmacology U.K. Office, P.O. Box II,
(Executive Editor) Cullompton, Devon EX15 1TQ, U.K.
Prof. J. GIELEN Université de Liége, Laboratoire de Chimie Médicale, Insti-
tut de Pathologie, B-4000 Sart-Tilman par Liége 1, Belgium
Associate Editors
Prof. MARTIN K. CHuRCH Clinical Pharmacology, Centre Block, Southampton General
Hospital, Southampton SO9 4XY, U.K.
Dr. PIERRE LADURON Département de Biologie, Rhéne-Poulenc Santé, Centre de
Recherches de Vitry, 13, quai Jules Guesde, 94403 Vitry sur
Seine, France
American Continent
Prof. ALAN C. SARTORELLI Yale University School of Medicine, Department of
Pharmacology, Sterling Halli of Medicine, 333 Cedar Street,
P.O. Box 3333, New Haven, Connecticut 06510-8066, U.S.A.
Associate Editors
Prof. YUNG-CHI CHENG Yale University School of Medicine, Department of
Pharmacology, Sterling Hall of Medicine, 333 Cedar Street,
P.O. Box 3333, New Haven, Connecticut 06510-8066, U.S.A.
Prof. PrisciLLa S. DANNIES Yale University School of Medicine, Department of
Pharmacology, Sterling Hall of Medicine, 333 Cedar Street,
P.O. Box 3333, New Haven, Connecticut 06510-8066, U.S.A.
Prof. R. H. RoTH Yale University School of Medicine, Department of
Pharmacology, Sterling Hall of Medicine, 333 Cedar Street,
P.O. Box 3333, New Haven, Connecticut 06510-8066, U.S.A.
Dr. B. Z. RENKIN Yale University School of Medicine, Department of
Pharmacology, 47 College Street, Suite 226, New Haven,
Connecticut 06510-3209, U.S.A.
Commentaries Editor
Prof. C. NORMAN GILLIS Yale University School of Medicine, Departments of Anes-
thesiology and Pharmacology, Sterling Hall of Medicine, 333
Cedar Street, P.O. Box 3333, New Haven, Connecticut
06510-8066, U.S.A.
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EDITORIAL ADVISORY BOARD
American Continent
i AXELROD—National Institutes of Health, Bethesda, bi +" _licaaiaa Associates, 60 Audubon Road,
e
MicuaeL R. Boyp—Developmental Therapeutics Program, Wa ter M. LovenseERG—Marion Merrell Dow Research In-
National Cancer Institute, Executive Plaza North, stitute, Cincinnati, OH
Rockville, MD P. N. Macee—Temple University School of Medicine,
EpwarD BresNiCkK— rtment of Pharmacology and Toxi- Philadelphia, PA
cology, Dartmouth Medical School, Hanover, NH G. J. MANNERING—Department of Pharmacology, University
D. N. BRInDLEY—Faculty of Medicine, University of Alberta, of Minnesota Medical School, Minneapolis, MN
Edmonton, Canada Tac E. Mansour—Department of Pharmacology, Stanford
MicuaeL J. Brownstein—National Institutes of Health, University Medical Center, Stanford, CA
Bethesda, MD Pau. B. McCay—Oklahoma Medical h Foundation
Jack R. Coorer—Yale University School of Medicine, New Oklahoma City, OK
Haven, CT Hersert Y. MeELtzer—Case Western Reserve University,
James K. Cowarp—Col of Pharmacy, University of Cleveland, OH
Michigan, Ann Arbor, EstepaN Mezey—-Johns Hopkins University School of
Ian Creese—Center for Molecular and Behavioral Neuro- Medicine, Baltimore, MD
science, Aidekman Research Center, Newark, NJ Danie. W. Nesert—Department of Environmental Health,
Joun W. Daty—National Institutes of Health, Bethesda, MD University of Cincinnati, Cincinnati, OH
Erwin G. Erpés—Department of Pharmacology, University Cuar.es A. Nicuoc—Cannam Enterprises, 1508 Ward Street,
of Illinois, College of Medicine, Chicago, IL Durham, NC
--% ErecinskA—University of Pennsylvania, Philadelphia, Rosert E. Parks, Jk—Brown University, Providence, RI
A GasrieL L. PLaa—University of Montreal, Quebec, Canada
Ray W. FuLLer—Lilly Research Laboratories, Indianapolis, IN EuGene Roserts—City of Hope Medical Center, Duarte,
=~ C. GaLto—National Institutes of Health, Bethesda, CA
M Jerome A. Rotu—State University of New York, Medical
James R. GiLLetre—National Institutes of Health, Bethesda, Center, Buffalo, NY
MD Cuar.es O. RutLepGe—School of Pharmacy, Purdue Univer-
Rosert I. GLazer—Georgetown University, Washington, DC sity, West Lafayette, IN 47907
I. Davip GoLDMAN—Medical College of Virginia, Richmond, Boris TABAKOFF—National Institutes of Health, Bethesda,
VA MD
Tueopore E. GramM—1036 Welsh Drive, Rockville, MD Joun F. TALLMAN—Yale University, School of Medicine, New
M. R. HanLtey—School of Medicine, University of California, Haven, CT
Davis, CA Snorri Sv. THORGEIRSSON—National Institutes of Health,
G. H. Hitcuincs—Wellcome Research Laboratories, Research Bethesda, MD
Triangle Park, NC Davip C. U’Pricharp—ICI Americas Inc., Stuart Pharma-
Louis J. IgGNARRO—UCLA School of Medicine, Department ceuticals, Wilmington, DE
of Pharmacology, Los Angeles, CA MARTHA VAUGHAN—National Institutes of Health, Bethesda,
Wi.uaM B. Jakospy—National Institutes of Health, Bethesda, MD
MD NorMan Weiner—Abbott Laboratories, Abbott Park, IL
Davip G. Jouns—National Institutes of Health, Bethesda, ARNOLD D. Wetcu (Chairman)—Frederick Cancer Research
MD Facility of National Cancer Institute, Frederick, MD
Haro_p KALant— University of Toronto, School of Medicine, Joun R. WiLtiAaMson—University of Pennsylvania, Philadelphia,
Toronto, Ontario, Canada PA
European Continent
F. — BeLpaireE—J. F. and C. Heymans Institute of Pharma- G. MituiGan—Department of Biochemistry, University of
Ary Rijksuniversity, Ghent, Belgium Glasgow, Glasgow, U.K.
BLAKELEY—Department of Physiology, The Univer- P. Mo_peus—Department of Toxicology, Karolinska Insti-
< Leicester, U.K. tute, 104 01 Stockholm 60, Sweden
K. Bock—Institute of Toxicology, Tiibingen University, G. J. Mutper—Department of Toxicology, University of
FRR. G. Leiden, Sylvius Laboratories, P.O. Box 9503, 2300 RA
J. | ins Mary’s Hospital Medical School, London, Leiden, The Netherlands
K. J. NerreER—Department of Pharmacology and Toxicology,
R. A. J. CHALLiss—Department of Pharmacology, University Philipps University, Marburg, Germany
of Leicester, Leicester, U.K. H. Nou_—Institute of Pharmacology and Toxicology, Uni-
T. A. Connors—MRC Toxicology Unit, Carshalton, Surrey, versity of Vienna, Vienna, Austria
U.K. A. J. Paine—St Bartholomew's Hospital Medical School,
E. De CLercq—Rega Institute for Medical Research, Univer-
sity of Leuven, Bel London, U.K.
J. Frere—lInstitute RcC himie, Université de Liége, Liége, B. K. Pank—Department of Pharmacology and Therapeutics,
Belgium University of Liverpool, Liverpool, U.K.
T. GopFrainp—Université Catholique de Louvain, Belgium E. Rei>—Guildford Academic Associates, Guildford, Surrey,
R. J. GryGiewski—School of Medicine, Cracow, Polan U.K.
J. Hamon—INSERM U288, Neurobiol Cellulaire et Fonc- E. Reiner—Yugoslav Academy of Sciences and Arts, 4100
tionnelle, Faculté de Medecine Pitie-Salpetriere, 91 Blvd de Zagreb, Yugoslavia
l’'H6pital, F-75634 Paris Cédex 14, France A. G. Renwick—University of Southampton, Faculty of
J. Hanoune—INSERM U99, Hopital Henri Mondor, Creteil, Medicine, Southampton, U.K
France P. J. Roperts—Department of Physiology and Pharmacology,
J. A. HickmMan—Department of Physiological Sciences, Medical and Biological Sciences Building, Southampton,
University of Manchester, Manchester, U.K. U.K.
I. JankO—Institute of Pharmacology, Czechoslovak Academy M. SANDLER—Bernhard Baron Memorial Research Labora-
of Sciences, Czechoslovakia tories, Queen Charlotte’s Maternity Hospital, London, U.K.
P. Jenner—Department of Pharmacology, King’s College, H. Sies—Institut fiir Physiologische Chemie 1, Universitat
London SWS 8AF, U.K. Diisseldorf, Diisseldorf, Germany
H. Kappus—Freie Universitat Berlin, Germany
J. Skopa—Institute of Organic Chemistry and Biochemistry,
J. LunpserG—Department of Pharmacology, Karolinska Czechoslovak Academy of Sciences, Prague, Czechoslo-
G. InPs.t itMuAteNtN, AESRtoTcSk—hDoilem,n stS wedFearnm akoligie, Campus Gasthuis- vakia
B. Testa—Department of Pharmacy, University of Lausanne,
bBeerlgg,i uOmn derwijs en Navorsing, Herestraat, 3000 Leuven, Lausanne, Switzerland
D. Mansuy—Université René Descartes, Laboratoire de K. Tipton—Department of Biochemistry, University of
Chimie et de Biochemie, Cg et Toxicolo- Dublin, Trinity College, Ireland
paves, 45 rue des Saints-Péres, 75270 Paris Cédex 05, V. Utiricx—Fakultat fiir Biologie, Universitét Konstanz,
rance Konstanz, Germany
A. E. M. McLean—De: rtment of Clinical Pharmacology, P. WALDMEIER—Ciba-Geigy Limited, CH-4002 Basle, Switzer-
peaty College ospital Medical School, London, land
M. B. H. Youpim—Technion-Israel Institute of Technolo
Cc.3 ‘MEApE—Department of apy ong Twa Faculty of Medicine, Department of Pharmacology,
Ingelheim KG, D-6507 Ingelheim am Rhein, Galim, Haifa, Israel
Asia and Pacific Rim
K. KurivaMa—Kyoto Prefectural University of Medicine, T. Watase—Tokyo College of Pharmacy, Tokyo, Japan
Kyoto, Japan
AIMS AND SCOPE
BIOCHEMICAL PHARMACOLOGY is an international journal which publishes research findings in pharmacology
deriving from investigations that employ the disciplines of biochemistry, biophysics, molecular biology, genetics,
structural biology, computer models and/or physiology. Reports of studies with intact animals, organs, cells,
subcellular components, enzymes or other cellular molecules and model systems are acceptable if they define
mechanisms of drug action. Descriptive miathematical models including those involving computer techniques are
also welcome. Experiments involving the use of drugs to elucidate physiological and behavioral mechanisms in
living organisms are also within the scope of the journal. In general, papers which record concentrations of drugs
and metabolites in body fluids will only be accepted if they contribute to an understanding of biochemical and
biophysical mechanisms. The Editors, however, reserve the right to publish any papers of major interest in the
field. Only contributions in English can be considered or published.
The journal publishes the following types of communication:
(1) Full-length Papers. These consist of a body of work presenting original findings relating to the question
proposed by the investigators undertaking the research.
(2) Short Communications. These consist of an original body of work of narrower scope but of the same quality
as the above. By definition, these papers are shorter than full-length manuscripts.
(3) Rapid Communications. These promote rapid dissemination of timely and significant observations within
the scope of the journal. Manuscripts must be submitted in English and will be judged as appropriate for
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emphasize clearly the novel aspects of the research. These criteria will be applied strictly. In order to speed up
the publication of rapid communications, authors are encouraged to use the special laysheets available from any
of the Regional Editors.
(4) Commentaries are short commissioned review articles (3000-5000 words in length). They are designed to
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intended to stimulate thought. They can be controversial, and can either focus on areas subject to much activity,
or draw attention to relatively neglected fields in which there are both the opportunity and the need for research
in biochemical pharmacology. Particularly welcome will be Commentaries in which authors present their personal
view on the state of the subject on which they are reporting, and give their view as to where in the near or distant
future the subject may be moving. Authors are especially encouraged to take issue with popular dogmas. The
Commentary series is edited by Professor C. Norman Gillis.
In order to increase the exchange of information and ideas, the Journal will also publish Comments on a
Commentary, in which selected, highly qualified authorities are invited to offer their own observations on
Commentary articles, which will be published in the same issue of the Journal, and thus provide some alternative
thoughts on important areas of research. For further information see Biochem Pharmacol 31, 2568 (1982).
While the final decision on selection of authors for either Commentaries or Comments on a Commentary will
be made at the discretion of the editor, suggestions from readers will be welcome. These should be addressed
to: Professor C. N. Gillis, Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street,
New Haven, Connecticut 06510.
(5) Meeting Reports. The journal is prepared to publish as preliminary communications short, factual two-page
summaries of selected papers from small meetings or conferences. The meetings should be those where attendance
is by invitation and all papers to be published will be refereed. Organizers who wish to have their meetings
published in this way should contact the appropriate Regional Editor.
Notes for Contributors can be found in all issues and Abbreviations in issues 1 and 7
CONTENTS OF VOLUME 42
21 JUNE 1991
Rapid Communications
Davip J. PoruBex, SUSAN M. SANINS, Metabolic chiral inversion of flurbiprofen-CoA in vitro
Jerrrey R. STEPHENS, MARK P. GRriLLo,
Davin G. KAISER,
Gorpon W. HALSTEAD,
Wane J. ADAMs and
Tuomas A. BAILLIE
Sue A. KEILBAUGH, The PC12 cell as a model for studies of the mechanism
WiiviaM H. Prusorr and of induction of peripheral neuropathy by anti-HIV-1
MELvin V. SIMPSON dideoxynucleoside analogs
Commentary
ALAN R. SALTIEL, JEFFREY RAVETCH Functional consequences of lipid-mediated protein—
and ALAN A. ADEREM membrane interactions
Research Papers
IAN COTGREAVE, PETER MOLDEUS The metabolism of N-acetylcysteine by human endothelial
and INA SCHUPPE cells
MASANORI YOSHIZUMI, Characterization of palytoxin-induced catecholamine
ATSUSHI NAKANISHI, secretion from cultured bovine adrenal chromaffin cells.
Hitosu! Houcui, Kyon Morita Effects of Na*- and Ca’*-channel blockers
Itsuo KaTOH and Motoo OKA
HEMENDRA N. BHARGAVA, Down-regulation of brain and spinal cord x-opiate recep-
Anit GuLATI and Popuri RAMARAO tors in spontaneously hypertensive, Wistar—-K yoto normo-
tensive, and Sprague-Dawley rats by chronic treatment
with U-50,488H
Jan N. M. COMMANDEUR, Metabolism of L-cysteine S-conjugates and N-(trideutero-
GERARD J. STUNTIJES, acetyl)-L-cysteine S-conjugates of four fluoroethylenes in
JANET WUNGAARD and the rat. Role of balance of deacetylation and acetylation
Nico P. E. VERMEULEN in relation to the nephrotoxicity of mercapturic acids
REIKO NATSUKI Effect of ethanol on calcium-uptake and phospholipid
turnover by stimulation of adrenoceptors and muscarinic
receptors in mouse brain and heart synaptosomes
JoHn Dawson, RICHARD G. KNOWLES Quantitative studies of sulphate conjugation by isolated
and CHRISTOPHER I. POGSON rat liver cells using [**S]sulphate
EDWARD T. MORGAN Suppression of P450IIC12 gene expression and elevation
of actin messenger ribonucleic acid levels in the livers of
female rats after injection of the interferon inducer poly
rl-poly rC
List of Contents and Author Index for Volume 42, 1991
ANGELA Ruck, Davip A. KENDALL 59 «a-and B-Adrenoceptor regulation of cyclic AMP accumu-
and STEPHEN J. HILL lation in cultured rat astrocytes. A comparison of primary
protoplasmic and mixed fibrous/protoplasmic astroglial
cultures
WiILiaM C. Buss and Dissociation of decreases in renal cellular energetics and
RICHARD GRIFFEY recovery of rcual microsomal translation during chronic
cyclosporine A administration
RICHARD BERTRAND, Cell death induced by topoisomerase inhibitors. Role of
DonNA KERRIGAN, MONICA SARANG calcium in mammalian cells
and Yves POMMIER
DONATA BRANCA, Influence of the anesthetic 2,6-diisopropylphenol on
MICHELA S. ROBERTI, the oxidative phosphorylation of isolated rat liver
PAOLA LORENZIN, Ez10 VINCENTI mitochondria
and Guipo SCUTARI
THOMAS SPECTOR, Herpes and human ribonucleotide reductases. Inhibition
Joan A. HARRINGTON and by 2-acetylpyridine 5-{(2-chloroanilino)-thiocarbonyl]-
Davip J. T. PoRTER thiocarbonohydrazone (348U87)
YOSHIAKI OMATA and A fluorescence study of the interactions of benzo[a]pyrene,
FreD K. FRIEDMAN cytochrome P450c and NADPH-cytochrome P450
reductase
TERUAKI AKAO, TAIKO AKAO, Metabolism of glycyrrhetic acid by rat liver microsomes—
Mungo AOYAMA and K YOICHI KoOBASHI Ill. Male-specific glycyrrhetinate dehydrogenase
ANDREW D. AyYRTON, Induction of the cytochrome P450 I and IV families and
Costas IOANNIDES and peroxisomal proliferation in the liver of rats treated with
Dennis V. PARKE benoxaprofen. Possible implications in its hepatotoxicity
CHRISTINE GODIN, ANTHONY D. SMITH Bradykinin stimulates DNA synthesis in competent Balb/c
and Patrick A. RILEY 3T3 cells and enhances inositol phosphate formation
induced by platelet-derived growth factor
D. J. Keevinc, R. C. MALCOLM, SK&F 96067 is a reversible, lumenally acting inhibitor of
S. M. Laine, R. J. Ire and C. A. LEACH the gastric (H* + K*)-ATPase
JONATHAN MAYBAUM, Divergent patterns of incorporation of bromodeoxy-
Eric C. Burton, Davip A. SHELTON, uridine and iododeoxyuridine in human colorectal tumor
HoNG-WEI JING, cell lines
CHRISTINE E. DUSENBURY,
WituiaM D. ENSMINGER and
Puiuip L. STETSON
Evan P. GALLAGHER, Glutathione S-transferase-mediated — chlorothalonil
Grecory L. KEDDERIs and metabolism in liver and gill subcellular fractions of
RIcHARD T. Di GIuLIO channel! catfish
BarBARA A. DomIN, Desciclovir permeation of the human erythrocyte mem-
WILLIAM B. MAHony and brane by nonfacilitated diffusion
THOMAS P. ZIMMERMAN
CHRISTIAN SCHUDT, SUSANNE WINDER, Zardaverine as a selective inhibitor of phosphodiesterase
BeTINA MULLER and DieTeR UKENA isozymes
JEAN-MARC HERBERT and Tumor cell adherence to cultured capillary endothelial
JEAN-PIERRE MAFFRAND cells is promoted by activators of protein kinase C
ELIZABETH S. LAPADULA, Persistent alterations of calmodulin kinase II activity in
DanigEL M. LAPADULA and chickens after an oral dose of tri-o-cresyl phosphate
MOHAMED B. Asou-DOoNIA
Short Communications
Wes.ey W. Day and Myron WEINER Inhibition of hepatic drug metabolism and carbon tetra-
chloride toxicity in Fischer-344 rats by exercise
Urusa INTRASUKSRI and Comparison of the effects of selected monocarboxylic,
Dennis R. FELLER dicarboxylic and perfluorinated fatty acids on peroxisome
proliferation in primary cultured rat hepatocytes
List of Contents and Author Index for Volume 42, 1991
Tuomas D. Boyer and Eric OLSEN 188 Role of glutathione S-transferases in heme transport
Kyosi Morita, ATSUSHI NAKANISHI, 190 Inhibitory action of brovincamine on catecholamine
YOSHIHIRO MURAKUMO, secretion from cultured bovine adrenal medullary cells:
Mortoo Oxa and HitosHi Houcui possible relation to its blocking action on Ca?* channels
VEERAPOL KUKONGVIRIYAPAN, Substrate transport and cyclosporin A in isolated rat
BARBARA KOTECKA and hepatocytes
NEILL H. STACEY
ANDREW E. FILDERMAN and Murine strain differences in pulmonary bleomycin
JOHN S. Lazo metabolism
5 JULY 1991
Commentary
NorMAN H. LEE and Allosteric antagonists of the muscarinic acetylcholine
EsaM E. EL-FAKAHANY receptor
Research Papers
ALLAN R. MooRMAN, Antiprotozoal activity of 3’-deoxyinosine. Inverse corre-
STEPHEN W. LAFon, DONALD J. NELSON, lation to cleavage of the glycosidic bond
Herp! H. Carter, J. JosePH MARR
and RANDOLPH L. BERENS
YONG-WHA Kwon and Interactions of local anesthetics with neuronal 1,4-
Davip J. TRIGGLE dihydropyridine binding sites
H1rROKO KISHIKAWA, Histidine decarboxylase measurement in brain by '*CO,
SAMUEL M. WILLINGER, trapping
STEPHEN JACKOWSKI, KIM BARKE
and Linpsay B. HouGH
REIKO NATSUKI Effect of ethanol on phospholipid turnover and calcium
mobilization in chick embryos
S. FLEMINGER The relationship between the occupation of the D-1
dopamine receptor by [>H]piflutixo! and the activity of
dopamine-sensitive adenylate cyclase in rat striatal
membranes
TOMOKO NISHIMAKI-MOGAMI, Effect of sorbic acid feeding on peroxisomes and sorboyl-
AKIRA TANAKA, KEN-ICHIRO MINEGISHI CoA metabolizing enzymes in mouse liver. Selective induc-
and ATSUSHI TAKAHASHI tion of 2,4-dienoyl-CoA hydratase
PETER G. W. PLAGEMANN Na*-dependent, concentrative nucleoside transport in
rat macrophages. Specificity for natural nucleosides and
nucleoside analogs, including dideoxynucleosides, and
comparison of nucleoside transport in rat, mouse and
human macrophages
CHRISTINE NOLTE, Comparison of vasodilatory prostaglandins with respect
MARTIN EIGENTHALER, to cAMP-mediated phosphorylation of a target substrate
PETER SCHANZENBACHER and in intact human platelets
ULRICH WALTER
José M. Lizcano, Epuarp Escricn, Amine oxidase activities in rat breast cancer induced
TERESA RIBALTA, JAUME MUNTANE experimentally with 7,12-dimethylbenz(«)anthracene
and MERCEDES UNZETA
Ros Leurs, MARION M. Brozius, Histamine H,-receptor-mediated cyclic GMP production
WILcO JANSEN, AALT BAST in guinea-pig lung tissue is an L-arginine-dependent
and HENDRIK TIMMERMAN process
Guipo R. Y. De MEYER, Early atherosclerosis is accompanied by a decreased rather
Hippe BuLT and ARNOLD G. HERMAN than an increased accumulativn of fatty acid hydroxy-
derivatives
BP 42 Index—B
List of Contents and Author Index for Volume 42, 1991
GERALD Just and EGGEHARD HOLLER 285 Enhanced levels of cyclic AMP, adenosine(5’)tetra-
phospho(S’)adenosine and nucleoside 5’-triphosphates
in mouse leukemia P388/D, after treatment with cis-
diamminedichloroplatinum(I])
JOHN P. VANDEN HEUVEL, Inhibition of long-chain acyl-CoA synthetase by the
BENEDICT I. KusLikis, EARL SHRAGO peroxisome proliferator perfluorodecanoic acid in rat
and RICHARD E. PETERSON hepatocytes
MASAFUMI TOMITA Comparison of one-electron reduction activity against the
bipyridylium herbicides, paraquat and diquat, in micro-
somal and mitochondrial fractions of liver, lung and
kidney (in vitro)
Lestey A. STANLEY, Davip J. ADAMS, Differential effects of recombinant interferon on consti-
FRANCES R. BALKWILL, tutive and inducible cytochrome P450 isozymes in mouse
DorortKka GriFFIN and C. ROLAND WOLF liver
Hipeak! Fusisaki, HISASH! SHIBATA, Inhibitions of acid secretion by E3810 and omeprazole,
KryosH! OKETANI, MANABU MURAKAMI, and their reversal by glutathione
MASATOSHI FusiMoToO,
TSUNEO WAKABAYASHI, ISAO YAMATSU,
MAKOTO YAMAGUCHI, HIDEK!I SAKAI
and NoriaK! TAKEGUCHI
JoHN G. CLEMENT, SYLVESTER ROSARIO, Soman and sarin inhibition of molecular forms of acetyl-
ELAINE BESSETTE and NANCY ERHARDT cholinesterase in mice. Time course of recovery anc
reactivation by the oxime HI-6
Dipak K. PATEL, JOHN P. SHOCKCOR, Metabolism of a novel antitumor agent, crisnatol, by a
Sai Y. CHANG, CARL W. SIGEL human hepatoma cell line, Hep G2, and hepatic micro-
and Brian E. Huser somes. Characterization of metabolites
W. ALEXANDER SIMON, The H*,K*-ATPase inhibitor pantoprazole (BY1023/
CHRISTIAN BUDINGEN, SK&F96022) interacts less with cytochrome P450 than
SUSANNE FAHR, BURKHARD KINDER omeprazole and lansoprazole
and MARGA KOSKE
Gerrit Los, ELs VERDEGAAL, Cellular pharmacokinetics of carboplatin and cisplatin in
Hus P. J. M. NoTesBorn, relation to their cytotoxic action
MARJAN RUEVEKAMP,
ALEXANDER DE GRAEFF,
EeLcoW . MEESTERS,
DaAAN TEN BOKKEL HUININK and
J. Gorpon McViE
Peter A. MUNZEL, Site-specific hypomethylation of c-myc protooncogene in
ANNIE PFOHL-LESZKOWICZ, liver nodules and inhibition of DNA methylation by
ELKE ROHRDANZ, GERARD KEITH, N-nitrosomorpholine
Guy D1RHEIMER and
Kart WALTER Bock
CORNELIA NIEMANN, Rat adult hepatocytes in primary pure and mixed mono-
JEAN-CHARLES GAUTHIER, layer culture. Comparison of the maintenance of mixed
LYSIANE RICHERT. function oxidase and conjugation pathways of drug
Marit-AGnes IvANOv, CELINE MELCION metabolism
and ANDRE CORDIER
H. M. WorTecsoer, C. A. DE KRUIF, Comparison of cytochrome P450 isoenzyme profiles in
A. A. J. VAN lerset,H . E. FALKE, rat liver and hepatocyte cultures. The effects of model
J. NooRDHOEK and B. J. BLAAUBOER inducers on apoproteins and biotransformation activities
Epwarb G. MIMNAUGH, Biochemical and pharmacological characterization of
Craic R. FairCHILD, JOHN P. FRUEHAUF MCF-7 drug-sensitive and Adr® multidrug-resistant
and BiRANDRA K. SINHA human breast tumor xenografts in athymic nude mice
STEVEN H. BERNSTEIN, Effects of hexamethylene bisacetamide on induction of
MATTHEW L. SHERMAN, RALF Hass, monocytic differentiation of human U-937 myeloid
TAKASHI NAKAMURA, leukemia cells
SURENDER KHARBANDA and
DONALD W. KUFE
JEAN L. Grem and CARMEN J. ALLEGRA Sequence-dependent interaction of 5-fluorouracil and ara-
binosyl-S-azacytosine or |-f-p-arabinofuranosylcytosine
List of Contents and Author Index for Volume 42, 1991
Maria T. CRIVELLARI, 419 Eicosanoid release and mepyramine, LTC, and LTD,
Maria R. ACCOMAZZO, binding in passively sensitized human lung parenchyma in
TERESA VIGANO, DANIELA OLIVA, turo
MeuHMET ME LI, G. Enrico Rovati,
MAURIZIO MEZZETTI,
PIERANGELO BELLONI,
MASSIMO TORRE, ALBERTO VERGA,
GIANCARLO FOoLco and
SIMONETTA NICOSIA
MiGuet Lucas and Francisca SOLANO 425 Opposite effect of cytochalasin B on agonist-induced
respiratory burst in neutrophils and monocytes
THOMAS I. KALMAN, 431 Inhibition of cellular thymidylate synthesis by cytotoxic
EpMUND R. MARINELLI, BIN XU, propenal derivatives of pyrimidine bases and deoxy-
A. R. VENUGOPALA REDDY, nucleosides
FRANCIS JOHNSON and
ARTHUR P. GROLLMAN
Short Communications
RHEEM D. MEDH, VICRAM GUPTA Reversal of melphalan resistance in vivo and in vitro by
and YoGesH C. AWASTHI modulation of glutathione metabolism
SHUBHADA BHAMRE and Presence of flavin-containing monooxygenase in rat brain
VUAYALAKSHMI RAVINDRANATH
THEO J. VisseR, ELLEN KAPTEIN and Differential expression and ciprofibrate induction of
Ernit S. HARPUR hepatic UDP-glucuronyltransferases for thyroxine and
triidothyronine in Fischer rats
TADASHI ASAKURA, TAE SAKURAI, Effect of gabaculine on metabolism and release of ;-
TAKASHI HAYASHI and aminobutyric acid (GABA) formed from 4-aminobutyr-
MAKOTO MIATSUDA aldehyde in synaptosomes
A. NEGRE-SALVAYRE. V. REAUD, Protective effect of x-tocopherol, ascorbic acid and rutin
C. Hariton and R. SALVAYRE against peroxidative stress induced by oxidized lipo-
proteins on lymphoid cell lines
Announcement
Software Survey Section
JULY 1991
Commentary
MoRrENO PAOLINI, GIAN LUIGI BIAGI, Is clonal adaptation a product of evolution over the
CARLO BAUER and millennia?
G1torGio CANTELLI-FoRTI
Research Papers
SusANNA Y. H. Tse, I-ToNG Mak Antioxidative properties of harmane and f#-carboline
and BENJAMIN F. DICKENS alkaloids
Acnes GYURASICS, FERENC VARGA Glutathione-dependent biliary excretion of arsenic
and ZOLTAN GREGUS
MICHAEL SCHWENK, CHRISTA LINZ Conjugation of |-naphthol in the gastric mucosa of guinea
and A.-B. KOBUSCH pigs
JANE E. MACKIE, DONALD W. BACK, Elevation of d-aminolevulinic acid synthase and cyto-
JosHuA W. HAMILTON and chrome PB, P450 messenger RNA levels by dihydro-
GERALD S. MARKS pyridines, dihydroquinolines, sydnones, and N-ethyl-
protoporphyrin IX
Frep D. BEUSENBERG, Ros LEuRS, Sensitization enhances the adenylyl cyclase responsiveness
ANNEMIEK VAN SCHAIK, in alveolar macrophages. Changes induced at post-recep-
Jan G. C. VAN AMSTERDAM tor level
and IvAN L. BONTA
List of Contents and Author Index for Volume 42, 1991
V. Roaciers, S. COECKE, Effect of the aging process on the gender and pheno-
Y. VANDENBERGHE, F. MorEL, barbital dependent expression of glutathione S-transferase
A. CALLAERTS, G. VERLEYE, subunits in Brown Norway rat liver
C. F. A. VAN BEZOOUEN,
A. GUILLouZO and A. VexCRUYSSE
STEVEN C. SALARIS, Methylene blue as an inhibitor of superoxide generation
CHARLES F. Basss and by xanthine oxidase. A potential new drug for the attenu-
WituaM D. Vooruees III ation of ischemia/reperfusion injury
Joun B. J. Kwox and Inhibition of 2-desamino-2-methyl-10-propagyl-5,8-di-
MARTIN H. N. TATTERSALL deazafolic acid cytotoxicity by 5,10-dideazatetrahydro-
folate in L1210 cells with decrease in DNA fragmentation
and deoxyadenosine triphosphate pools
JANET R. WETHERELL and A comparison of the decarbamoylation rates of physostig-
Mary C. FRENCH mine-inhibited plasma and red cell cholinesterases of man
with other species
Eve A. ROBERTS, KATHENE C. JOHNSON Ah receptor mediating induction of cytochrome P4S50I1A1
and WoLFGANG G. DIPPOLD in a novel continuous human liver cell line (Mz-Hep-1).
Detection by binding with [H]2,3,7,8-tetrachiorodibenzo-
p-dioxin and relationship to the activity of aryl hydro-
carbon hydroxylase
Euisa DICKER and NADH-dependent generation of reactive oxygen species
ARTHUR I. CEDERBAUM by microsomes in the presence of iron and redox cycling
agents
ATsusHI MasubaA, DALE E. Mals, Platelet and vascular thromboxane A,/prostaglandin H,
JoHN E. Oatis Jr and receptors. Evidence for different subclasses in the rat
Perry V. HALUSHKA
Sam LINDGREN, ANA RASCON, Selective inhibition of cGMP-inhibited and cGMP-
KARL-ERIK ANDERSSON, noninhibited cyclic nucleotide phosphodiesterases and
VINCENT MANGANIELLO and relaxation of rat aorta
Eva DEGERMAN
MICHEL PIERRE, Early effect of BCNU on rat astrocytes. Inhibition of S6
MARTINE POMERANCE, kinase activation by growth factors
JEAN-MICHEL GAVARET,
SIMONE MOUSSET,
DANIELE TORU-DELBAUFFE
and JOSIANE PIERRE
ANDREA RESETAR, DOUGLAS MINICK Glucuronidation of 3’-azido-3’-deoxythymidine catalyzed
and THOMAS SPECTOR by human liver UDP-glucuronosyltransferase. Signifi-
cance of nucleoside hydrophobicity and inhibition by
xenobiotics
JOHN E. PILeTz, ANNE C. ANDORN, Binding of [H]-p-aminoclonidine to «,-adrenoceptor
JAMES R. UNNERSTALL and states plus a non-adrenergic site on human platelet plasma
ANGELOS HALARIS membranes
XIAO-LI Ma, ENRIQUE BARAONA, Effects of ethanol consumption on bioactivation and
JEROME M. LASKER and hepatotoxicity of N-nitrosodimethylamine in rats
CHARLES S. LIEBER
MITSUAKI OnTA, Davip NELSON, Relationships between energy level and insulin secretion in
JUNE NELSON, MARTIN D. MEGLASSON isolated rat islets of Langerhans. A study at various pH
and MARIA ERECINSKA values
JOHANN M. VAN ZYL, KAREN BASSON, Mechanisms by which clofazimine and dapsone inhibit the
ANDRE KRIEGLER and myeloperoxidase system. A possible correlation with their
BEN J. VAN DER WALT anti-inflammatory properties
FUSAKO MAEHIRA High prostaglandin-E, binding to serum protein in allergic
subjects
SURENDRA S. KATYARE and Altered energy coupling in rat heart mitochondria follow-
REMA R. RAJAN ing in vivo treatment with propranolol