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Biochemical Pharmacology 1991: Vol 42 Index PDF

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Preview Biochemical Pharmacology 1991: Vol 42 Index

(FOUNDED BY SIR RUDOLPH A. PETERS) SUBJECT INDEX FOR VOLUME 42, 1991 PREPARED BY W. COCKS Oxford : New York Seoul : Tokyo BIOCHEMICAL PHARMACOLOGY EDITORIAL BOARD Chairman: A. D. WELCH Regional Editors European Continent Prof. PETER ALEXANDER Biochemical Pharmacology U.K. Office, P.O. Box 11, (Executive Editor) Cullompton, Devon EX15 1TQ, U.K. Prof. J. GIELEN Université de Liége, Laboratoire de Chimie Médicale, Insti- tut de Pathologie, B-4000 Sart-Tilman par Liége 1, Belgium Associate Editors Prof. MARTIN K. CHURCH _ Clinical Pharmacology, Centre Block, Southampton General Hospital, Southampton SO9 4XY, U.K. Dr. PIERRE LADURON Département de Biologie, Rhéne-Poulenc Santé, Centre de Recherches de Vitry, 13, quai Jules Guesde, 94403 Vitry sur Seine, France American Continent Prof. ALAN C. SARTORELLI Yale University School of Medicine, Department of Pharmacology, Sterling Hall of Medicine, 333 Cedar Street, P.O. Box 3333, New Haven, Connecticut 06510-8066, U.S.A. Associate Editors Prof. YUNG-CHI CHENG Yale University School of Medicine, Department of Pharmacology, Sterling Hall of Medicine, 333 Cedar Street, P.O. Box 3333, New Haven, Connecticut 06510-8066, U.S.A. Prof. PRISCILLA S. DANNIES Yale University School of Medicine, Department of Pharmacology, Sterling Hall of Medicine, 333 Cedar Street, P.O. Box 3333, New Haven, Connecticut 06510-8066, U.S.A. Prof. R. H. RoTH Yale University School of Medicine, Department of Pharmacology, Sterling Hall of Medicine, 333 Cedar Street, P.O. Box 3333, New Haven, Connecticut 06510-8066, U.S.A. Dr. B. Z. RENKIN Yale University School of Medicine, Department of Pharmacology, 47 College Street, Suite 227, New Haven, Connecticut 06510-3209, U.S.A. Commentaries Editor Prof. C. NORMAN GILLIS Yale University School of Medicine, Departments of Anes- thesiology and Pharmacology, Sterling Hall of Medicine, 333 Cedar Street, P.O. Box 3333, New Haven, Connecticut 06510-8066, U.S.A. Publishing and Advertising Offices: Headington Hill Hall, Oxford OX3 OBW (Oxford 794141), and 395 Saw Mill River Road, Elmsford, NY 10523. Published two issues per month. Annual Institutional Subscription Rate (1992) £1410.00 (US$2560.00). Two-year Institutional Rate (1992/93) £2679.00 (US$4864.00). Sterling prices are definitive. US dollar prices are quoted for convenience only, and are subject to exchange rate fluctuation. Prices include postage and insurance and are subject to change without notice. Subscrip- tion rates for Japan are available on request. Personal subscription rate for those whose library subscribes at the regular rate is available on request. 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Postmaster send address corrections to Biochemical Pharmacology, c/o Pergamon Press Inc., 395 Saw Mill River Road, Elmsford, NY 10523, U.S.A. Copyright © 1992 Pergamon Press plc EDITORIAL ADVISORY BOARD American Continent JuLius AXELROoD—National Institutes of Health, Bethesda, YUTAKA KosBayAsHiI—Ko-By Associates, 60 Audubon Road, Wellesley, MA MICHAEL R. BoyD—NCI-FCRDC, Frederick, MD WALTER M. LovENBERG—Marion Merrell Dow Research In- EDWARD BrESNICK—Department of Pharmacology and Toxi- stitute, Cincinnati, OH cology, Dartmouth Medical School, Hanover, NH P. N. MAGeE—Temple University School of Medicine, D. N. BRINDLEY—Faculty of Medicine, University of Alberta, Philadelphia, PA Edmonton, Canada G. J. MANNERING—Department of Pharmacology, University MICHAEL J. BROWNSTEIN—National Institutes of Health, of Minnesota Medical School, Minneapolis, MN Bethesda, MD | TaG E. MANsouR—Department of Pharmacology, Stanford JACK R. Cooper—Yale University School of Medicine, New University Medical Center, Stanford, CA Haven, CT PauL_ B. McCay—Oklahoma Medical Research Foundation, JAMES K. Cowarp—College of Pharmacy, University of Oklahoma City, OK Michigan, Ann Arbor, MI HERBERT Y. MELTZER—Case Western Reserve University, IAN CrEESE—Center for Molecular and Behavioral Neuro- Cleveland, OH science, Aidekman Research Center, Newark, NJ EsTEBAN Mezey—Johns Hopkins University School of JOHN W. DALy—National Institutes of Health, Bethesda, MD Medicine, Baltimore, MD Erwin G. Erpés—Department of Pharmacology, University DANIEL W. NEBERT—Department of Environmental Health, of Illinois, College of Medicine, Chicago, IL University of Cincinnati, Cincinnati, OH MariA ERECINSKA—University of Pennsylvania, Philadelphia, CHARLES A. NicHo_—Cannam Enterprises, 1508 Ward Street, PA Durham, NC Ray W. FuLLer—Lilly Research Laboratories, Indianapolis, RosertT E. Parks, JR—Brown University, Providence, RI IN GABRIEL L. PLAA—University of Montreal, Quebec, Canada RosBert C. GALLO—National Institutes of Health, Bethesda, EuGENE Roserts—City of Hope Medica! Center, Duarte, MD CA JAMES R. GILLETTE—National Institutes of Health, Bethesda, JEROME A. RotH—State University of New York, Medical Center, Buffalo, NY RoBert I. GLAZER—Georgetown University, Washington, CHARLES O. RUTLEDGE—School of Pharmacy, Purdue Univer- DC sity, West Lafayette, IN I. Davip GOLDMAN—Medical College of Virginia, Richmond, Boris TABAKOFF—National Institutes of Health, Bethesda, THEODORE E. GRAM—1036 Welsh Drive, Rockville, MD JOHN F. TALLMAN—Neurogeu, 35 Northeast Industrial Road, M. R. HANLEY—School of Medicine, University of California, Branford, CT Davis, CA SNoRRI Sv. THORGEIRSSON—National Institutes of Health, G. H. Hitcuincs—Wellcome Research Laboratories, Research Bethesda, MD Triangle Park, NC Davip C. U’PRICHARD—ICI Americas Inc., Stuart Pharma- Louis J. IGNARRO—UCLA School of Medicine, Department ceuticals, Wilmington, DE of Pharmacology, Los Angeles, CA MARTHA VAUGHAN—National Institutes of Health, Bethesda, WILLIAM B. JAKoBy—National Institutes of Health, Bethesda, MD MD NorMAN WEINER—Abbott Laboratories, Abbott Park, IL Davip G. JoHNs—National Institutes of Health, Bethesda, ARNOLD D. WELCH (Chairman)—Frederick Cancer Research MD Facility of National Cancer Institute, Frederick, MD HAROLD KALANT— University of Toronto, School of Medicine, JOHN R. WILLIAMSON—University of Pennsylvania, Philadelphia, Toronto, Ontario, Canada PA European Continent F. M. BELPAIRE—J. F. and C. Heymans Institute of Pharma- G. MILLIGAN—Department of Biochemistry, University of cology, Rijksuniversity, Ghent, Belgium Glasgow, Glasgow, U.is. A. G. H. BLAKELEY—Department of Physiology, The Univer- P. Mo_peus—Department of Toxicology, Karolinska Insti- sity, Leicester, U.K. tute, 104 01 Stockholm 60, Sweden K. W. Bock—Institute of Toxicology, Tiibingen University, G. J. MuLpER—Department of Toxicology, University of F.R.G. Leiden, Sylvius Laboratories, P.O. Box 9503, 2300 RA J. CALDWELL—St. Mary’s Hospital Medical School, London, Leiden, The Netherlands K. J. NETTER—Department of Pharmacology and Toxicology, R.A. J. CHALLIss—Department of Pharmacology, University Philipps University, Marburg, Germany of Leicester, Leicester, U.K. H. Nout—Institute of Pharmacology and Toxicology, Uni- T. A. CoOnNNoRS—MRC Toxicology Unit, Carshalton, Surrey, versity of Vienna, Vienna, Austria U.K A. J. Paine—St Bartholomew’s Hospital Medical School, E. De CLERCQ—Rega Institute for Medical Research, Univer- London, U.K. sity of Leuven, Belgium B. K. PAakK—Department of Pharmacology and Therapeutics, J. FrereE—Institute de Chimie, Université de Liége, Liége, University of Liverpool, Liverpool, U.K. Belgium E. Reip>—Guildford Academic Associates, Guildford, Surrey, T. GODFRAIND—Université Catholique de Louvain, Belgium R. J. GRYGLEwski—School of Medicine, Cracow, Poland U.K J. HAMON—INSERM U288, Neurobiol Cellulaire et Fonc- E. REINER—Yugoslav Academy of Sciences and Arts, 4100 tionnelle, Faculté de Medecine Pitie-Salpetriere, 91 Blvd de Zagreb, Yugoslavia l'H6pital, F-75634 Paris Cedex 14, France A. G. Renwick—University of Southampton, Faculty of J. HANOUNE—INSERM U99, H6pital Henri Mondor, Creteil, Medicine, Southampton, U.K. France P. J. RopeErts—Department of Physiology and Pharmacology, J. A. HickKMAN—Department of Physiological Sciences, Medical and Biological Sciences Building, Southampton, University of Manchester, Manchester, U.K. U.K. I. JankU—Institute of Pharmacology, Czechoslovak Academy M. SANDLER—Bernhard Baron Memorial Research Labora- of Sciences, Czechoslovakia tories, Queen Charlotte’s Maternity Hospital, London, U.K. P. JENNER—Department of Pharmacology, King’s College, H. Sies—Institut fiir Physiologische Chemie 1, Universitat London SWS 8AF, U.K. Diisseldorf, Diisseldorf, Germany H. Kappus—Freie Universitat Berlin, Germany J. Skopa—Institute of Organic Chemistry and Biochemistry, J. LuUNpDBERG—Department of Pharmacology, Karolinska Czechoslovak Academy of Sciences, Prague, Czechoslo- Institutet, Stockholm, Sweden vakia G. P. MANNAERTS—Dienst Farmakoligie, Campus Gasthuis- B. Testa—Department of Pharmacy, University of Lausanne, berg, Onderwijs en Navorsing, Herestraat, 3000 Leuven, Lausanne, Switzerland Belgium K. Tipton—Department of Biochemistry, University of D. Mansuy—Universiteé René Descartes, Laboratoire de Dublin, Trinity College, Ireland Chimie et de Biochemie, Pharmacologiques et Toxicolo- giques, 45 rue des Saints-Péres, 75270 Paris Cedex 05, V. UL_rich—Fakultat fiir Biologie, Universitat Konstanz, France Konstanz, Germany A. E. M. McLean—Department of Clinical Pharmacology, P. WALDMEIER—Ciba-Geigy Limited, CH-4002 Basle, Switzer- University College Hospital Medical School, London, land U.K M. B. H. YoupiMm—Technion-Israel Institute of Technology, Cha MeApE—Department of Pharmacology, Boehringer Faculty of Medicine, Department of Pharmacology, Bat Ingelheim KG, D-6507 Ingelheim am Rhein, F.R.G. Galim, Haifa, Israel Asia and Pacific Rim K. KurryAMA—Kyoto Prefectural University of Medicine, T. WataBE—Tokyo College of Pharmacy, Tokyo, Japan Kyoto, Japan AIMS AND SCOPE BIOCHEMICAL PHARMACOLOGY is an international journal which publishes research findings in pharmacology deriving from investigations that employ the disciplines of biochemistry, biophysics, molecular biology, genetics, structural biology, computer models and/or physiology. Reports of studies with intact animals, organs, cells, subcellular components, enzymes or other cellular molecules and model systems are acceptable if they define mechanisms of drug action. Descriptive mathematical models including those involving computer techniques are also welcome. Experiments involving the use of drugs to elucidate physiological and behavioral mechanisms in living organisms are also within the scope of the journal. In general, papers which record concentrations of drugs and metabolites in body fluids will only be accepted if they contribute to an understanding of biochemical and biophysical mechanisms. The Editors, however, reserve the right to publish any papers of major interest in the field. Only contributions in English can be considered or published. The journal publishes the following types of communication: (1) Full-length Papers. These consist of a body of work presenting original findings relating to the question proposed by the investigators undertaking the research. (2) Short Communications. These consist of an original body of work of narrower scope but of the same quality as the above. By definition, these papers are shorter than full-length manuscripts. (3) Rapid Communications. These promote rapid dissemination of timely and significant observations within the scope of the journal. Manuscripts must be submitted in English and will be judged as appropriate for publication as rapid communications on the basis of their immediate importance. They should be written to emphasize clearly the novel aspects of the research. These criteria will be applied strictly. In order to speed up the publication of rapid communications, authors are encouraged to use the special laysheets available from any of the Regional Editors. (4) Commentaries are short commissioned review articles (3000-5000 words in length). They are designed to be editorial statements on selected topics, and should not be exhaustive reviews. Primarily, Commentaries are intended to stimulate thought. They can be controversial, and can either focus on areas subject to much activity, or draw attention to relatively neglected fields in which there are both the opportunity and the need for research in biochemical pharmacology. Particularly welcome will be Commentaries in which authors present their personal view on the state of the subject on which they are reporting, and give their view as to where in the near or distant future the subject may be moving. Authors are especially encouraged to take issue with popular dogmas. The Commentary series is edited by Professor C. Norman Gillis. In order to increase the exchange of information and ideas, the Journal will also publish Comments on a Commentary, in which selected, highly qualified authorities are invited to offer their own observations on Commentary articles, which will be published in the same issue of the Journal, and thus provide some alternative thoughts on important areas of research. For further information see Biochem Pharmacol 31, 2568 (1982). While the final decision on selection of authors for either Commentaries or Comments on a Commentary will be made at the discretion of the editor, suggestions from readers will be welcome. These should be addressed to: Professor C. N. Gillis, Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510. (5) Meeting Reports. The journal is prepared to publish as preliminary communications short, factual two-page summaries of selected papers from small meetings or conferences. The meetings should be those where attendance is by invitation and all papers to be published will be refereed. Organizers who wish to have their meetings published in this way should contact the appropriate Regional Editor. Notes for Contributors can be found in all issues and Abbreviations in issues 1 and 7 BIOCHEMICAL PHARMACOLOGY SUBJECT INDEX FOR VOLUME 42, 1991 A1110U inhibition of herpes and human ribo- 2-Acetylpyridine 5-((2-chloroanilino)- nucleotide reductases 91 thiocarbonyl )-thiocarbono- A80915A hydrazone inhibition of gastric H*t,Kt-ATPase inhibition of herpes and human ribo- 2019 nucleotide reductases 91 Acetaldehyde N-Acetyltransferase oxidation by aldehyde dehydrogenase in liver from human erythrocytes 979 effect of chloroquine and prima- Acetaminophen quine 954 effect on AZT metabolism in effect of streptolysin 0 702 hepatocytes 1475 phenotype and genotype in humans cytotoxicity of regioisomers in 1007 hepatocyte cultures 1137 «)-Acid glycoprotein — dicoumarol metabolism in rat in vivo, effect of effect of tricyclic drugs on CD chronic hypoxia 1029 spectra 729 protein binding S197 Aciduria sulphation by isolated liver cells etomoxir induced 1637 45 Acridine carboxamide Acetiamine 9-acridone formation in liver iodine complex and antithyroid cytosol 1879 activity S89 Actin-binding protein Acetone effect of toluene 805 induction of cytochrome P450 iso- Acyclic nucleoside phosphonates enzymes in liver S143 antiviral activity 963 N-Acetyl-p-benzoquinoneimine Acyclovir pr asais *etudes $197 permeation of human erythrocytes 147 Acetylcholine Acy1-CoA synthetase acidification of adrenal gland in liver, effect of perfluoro- perfusate S216 decanoic acid 295 evoked catecholamine release from Acyl glucuronides adrenals 973 reactivity 2289, 2301 Acetylcholinesterase 1-Acylglycerophosphocholine acetyl- platelet plasma membrane, effect of transferase cholesterol supplementation 2037 in kidney, induction by perfluoro- in red cells, physostigmine-inhibited, octanoic acid 1921 decarbamoylation 515 Adenosine release from adrenal gland S216 effect on atrial 86Rb efflux 655 second site of action of soman 2040 inhibition of phosphorylation of soman and sarin inhibition of troponin I in heart 685 molecular forms, reactivation by Adenosine analogues HI-6 329 effect on ATP in erythrocytes 1767 N-Acetylcysteine Adenosine Al receptor metabolism by human endothelial in brain, effect of halothane on cells 13 interaction witn G protein 1313 effect on nitric oxide generation Adenosine-3' ,5'-monophosphate from nitroglycerin 1433 in adipose tissue, effect of phorbol- protection against pulmonary edema 12-myristate l3-acetate 1/791 S47 in astrocytes, a&- and B-adrenoceptor scavenging of hypochlorous acid 2244 regulation 59 N-Acetyl-L-glutamate in CHO cells, isoproterenol induced in hepatocytes, effect of sodium accumulation 1683 benzoate 645 in chromaffin cells, effect of 2-Acetylpyridine 5((2-chloroanilino)- clonidine 2011 thiocarbonyl )-thiocarbonohydraz- in eosinophils, effect of phospho- 2 BIOCHEMICAL PHARMACOLOGY Adenosine-3',5'-monophosphate(contd. ) Adrenal gland(contd. ) phosphodiesterase inhibitors 937 depolarization induced acidification formation in cloned muscarinic of perfusates S216 receptors 1645 electrically-evoked catecholamine in HL-60 cells, elevation by trans- release 973 methylation inhibitors 1/761 effect of idebenone on catecholamine in neutrophils, ionophore A2318/7- formation 95] induced elevation ‘$105 imidazole receptors and signal in P388 cells, effect of cis-diammine transduction in chromaffin cells dichloroplatinum(II) 285 2011 in parotid gland, effect of epidermal Adrenaline growth factor 2333 binding to B-adrenergic receptors in in platelets, endothelial cell- S49 cells 1069 dependent regulation 253 dependent increase in hepatocyte in S49 lymphoma cells, effect of calcium, effect of menadione 1977 bromoacetylated derivatives of effect on verapamil binding in alprenolol and pindolol S212 hepatocytes 2239 in tracheal smooth muscle, effect of a-Adrenoceptor AH 21-132 663 in astrocytes, regulation of VIP-stimulated response in pinealo- cyclic AMP accumulation 59 cytes, effect of ethanol 1601 in <a role in ethanol toxicity Adenosine(5')tetraphospho(5' ) adenosine in P388 cells, effect of cis-diammine «]l=Adrenoceptors dichloroplatinum(II) 285 liver, effect of menadione 1977 (H+,Kt)-Adenosine triphosphatase pinealocytes, effect of ethanol on gastric VIP-stimulated cyclic AMP and inhibition by A80915A 2019 cyclic GMP responses 1601 inhibition by SK&F 96067 123 a2-Adrenoceptors inhibition by sofalcone 1447 platelets, p-aminoclonidine effect of lansoprazole enantiomers binding ~569 1875 p-Adrenoceptors (Na+,Xt)-Adenosine triphosphatase astrocytes, regulation of cyclic AMP in heart, inhibition by LND 623 S223 accumulation 59 Adenosine triphosphate brain, effect of antidepressants binding to LLC-PK} cells 1495 1525 in erythrocytes, effect of adenosine S49 cells, adrenaline binding 1069 analogues 1/767 P1-Adrenoceptors in kidney microsomes, effect of CHO-Hu cells, effect of nebivolol cyclosporine A 71 1683 in leukemic cells, effects of mafos- in skeletal muscle 1783 famide and etoposide 1859 2-Adrenoceptors role in insulin release from pancreat- CHO-Hu cells, effect of nebivolol ic islets 595 1683 role in sinusoidal transport of lymphocytes and lymphoma cells 1329 dibromosulfophthalein 1997 skeletal muscle 1/783 Adenosine triphosphate analogues Adriamycin effect on ribonucleotide reductase polyploidy induction 2199 759 resistance in vivo 391 S-Adenosylhomocysteine toxicity and DNA damage 2253 effect on ATP in erythrocytes 1/767 toxicity in heart mitochondria, Adenylate cyclase effect of schisanhenol 1805 in adipose tissue, effect of phorbol AF-DX 116 12-myristate 13-acetate 1/791 affinity at cloned mescarinic in alveolar macrophages, effect of receptors 1645 sensitization 485 effect on muscarinic receptors in dopamine sensitive in brain, effect diabetic rat prostate $113 of piflutixol 229 Aging in lymphoma cells 1069, 1329 effect on glutathione S-transferase effect of p- bromophenacy] bromide subunits in rat liver 491 1941 Aglycone flavonoids in parotid gland, epidermal growth effect on eicosanoid synthesis and factor-mediated stimulation 2333 lipid peroxidation 1673 Adipocytes Agmantine effect of polymyxin B on glucose ornithine decarboxylase regulation transport 1399 1045 aG2Phoea oLoae A Adipose tissue AR 21-132 effect of phorbol 12-- myristate inhibition of cyclic AMP phospho- 13-acetate on cyclic AUP in 1791 diesterase in tracheal smooth Adrenal gland muscle 663 effect of brovincamine on catechol- Ah receptor amine secretion 190 in Mz-Hep-1 cells 521i carbonyl reduction in subcellular Airway smooth muscle fractions, rodents S189 cyclic AMP phosphodiesterase BIOCHEMICAL PHARMACOLOGY Airway smooth muscle(contd.) ¥y¥-Aminobutyric acid B receptor inhibition by AH 21-132 663 in brain, effect of antidepressants AL-1576 1525 effect on ascorbate oxidation 1273 p-Aminoclonidine Albumin ~ binding to platelets 569 in CSF, indomethacin binding 799 N- (6-Aminohexy1 )-5-chloro-1-naphthal- human serum enesulfonamide diflunisal acyl glucuronide effect on cyclic AMP in neutrophils interaction 2301 S105 PGE} binding in allergic subjects stimulation of K* transport in human 609 epithelia 1039 Aldehyde dehydrogenase 5-Aminolevulinic acid in cyclophosphamide-resistant effect on mixed-function oxidase and L1210 cells 1933 UDP-glucuronosyltransferase in in erythrocytes, kinetics 979 Hep G2 cells’ 1307 in liver 5-Aminolevulinic acid synthase mRNA effect of disulfiram and metabol- in embryo hepatocytes, effect of ites 1361 dihydropyridines, dihydroquinol- retinaldehyde oxidation 1279 ines, sydnones and N-ethylproto- Aldose reductase porphyrin IX 475 in lens, inhibition by (2,6-dimethyl- Aminopeptidase P phenylsulphonyl )nitromethane ¥$ y Be in oO kinin analogue metabolism Aldose reductase inhibitors 21 inhibition of ascorbate oxidation Aminopterin 1273 5,8-dideaza analogues, metabolism by Alimemazine liver folylpolyglutamate iodine complex and antithyroid synthatase 833 activity S89 4-Aminopyridine Alizarin yellow R effect on agonist induced atrial antioxidative activity 1177 86Rb efflux 655 Allergy Aminopyrine PGE; binding to serum proteins 609 uptake by gastric glands, effect of Allosteric muscarinic antagonists 199 E3810 and omeprazole 321 Alloxan Aminopyrine N-demethylase thiol reactivity, hydrophilicity in liver microsomes, effect of and stability 1385 streptolysin O 702 Alprazolam 5-Aminosalicyclic acid attenuation of discontinuation effects neutrophil derived metabolite 1869 by carbamazepine S99 2-Aminothiazole Alprenolol iodine complex and antithyroid bromoacetylated derivatives, partial activity S89 agonistic activity $212 3-Amino-1,2,4-triazole Althesin effect on brain catalase 699 effect on erythrocyte membrane Amiodarone fluidity 1947 accumulation by alveolar macro- Alveolar macrophages phages S151 accumulation of amiodarone and Amphotericin B desethylamiodarone S151 effect on erythrocyte membrane adenylyl cyclase responsiveness 485 fluidity 1947 Amiloride Ampicillin effect on glucose 6-phosphatase in effect on neutrophil cytolysis 2317 hepatocytes S27 Amsacrine effect on hepatic bile acid uptake polyploidy induction 2199 $135 Anaesthetics, general Amine oxidases 2,6-diisopropylphenol effects on dopamine metabolism in retina 2355 oxidative phosphorylation in semicarbazide-sensitive in breast liver 8/7 cancer induced with 7,12-dimethyl- effect on erythrocyte membrane benz(~)anthracene 263 fluidity 1947 Aminoacridines Anaesthetics, local toxicity and DNA damage 2253 interaction with neuronal 1,4- 4-Aminobutyraldehyde dihydropyridine binding sites GABA gormation in synaptosomes, 213 effect of gabaculine 447 Androstenedione 6B-hydroxylase ¥-Aminobutyric acid in liver, effect of anhydroerythro- formed from 4-aminobutyraldehyde in mycin 2085 synaptosomes 44/7 Androstenedione 16-hydroxylase X¥-Aminobutyric acid A receptor in liver, effect of vitamin E 2107 effect of carbamazepine after Angiotensin I alprazolam discontinuation S99 metabolizing enzymes in mesenteric modulation of morphine inhibition arterial bed perfusate 1897 of noradrenaline release S121 Angiotensin II X¥-Aminobutyric acid B receptor pulmonary vasoconstriction, effect 4 BIOCHEMICAL PHARMACOLOGY Angiotensin II(contd.) Arabinosyl-5-azacytosine of diphenyleneiodinium R9 5-fluorouracil interaction in colon regulation of phosphate transport in cancer cells 409 cardiac myocytes 1123 Arachidonic acid role in ovulation 715 metabolism in blood cells, effect of Angiotensin converting enzyme SK&F 105561 and 105809 813 in serum, inhibition by enalaprilat metabolism in platelets, effect of 1729 fish oil hydroxyfatty acids 959 Anhydroerythromycin release in astrocyte cultures, effect inhibition of drug oxidation 2085 of pertussis and cholera toxins Aniline hydroxylase 1267 in hepatocyte cultures 381 Arecoline in liver microsomes effect on Ca2+ release from gastric effect of exercise 181 parietal cells 839 effect of streptolysin O 702 Arginine Antagonist drugs dependent histamine H}-receptor- binding promiscuity Sl mediated cyclic GMP production Antibiotics in lung 271 DNA base damage 1595 Aroclor 1254 effect on erythrocyte membrane effect on plasma lipoprotein metab- fluidity 1947 olism in chicks 1493 effect on neutrophil cytolysis 2317 Arsenic Anticholinesterases glutathione-dependent biliary effect on protein accessibility in excretion 465 electroplax 1463 Artery Anticoagulants pulmonary, effect of diphenylene- dermatan sulfates 1609 iodonium on hypoxic constriction Antidepressants R9 effect on GABAp and p-adrenoceptors Arthritis in brain 1525 effect of flosulide and metabolites Antifolates 1913 effect on keratinocytes S39 Aryl hydrocarbon hydroxylase Anti-inflammatory drugs in Mz-Hep-1 cells 521 granulocyte function 1913 2-Arylpropionic acids Antioxidant enzymes chiral inversion Rl, 1905 in liver, effect of cadmium + ethanol Ascorbic acid S9 in hepatocytes, effect of diquat- Antioxidants induced redox cycling 883 calcium antagonists and B-blockers effect on peroxidative stress in 735 lymphoid cells 450 B-carbolines 459 Ascorbic acid 2-Q-e-glucoside methylene blue 499 in vivo formation in guinea pigs peroxidative stress in lymphoid cells and rats 625 450 Aspartic acid e&l-Antiproteinase in hepatocytes, effect of sodium protection by lipoate against benzoate 645 oxidation by hypochlorous acid stimulation of Nat efflux from 2244 forebrain membrane vesicles 1811 Antithrombotic agents Astrocytes dermatan sulfates 1609 eé- and P-adrenoceptor regulation of Aorta cyclic AMP accumulation 59 atherosclerosis and fatty acid BCNU inhibits S6 kinase activation hydroxyderivatives 279 553 induction of stress protein in G-protein controlled prostaglandin endothelial cells by prosta- synthesis 1267 glandins 777 Atenolol nitric acid generation from nitro- antioxidant activity 735 prusside S157 Atherosclerosis phosphodiesterase isoenzymes in 545 13-hydroxylinoleic acid and 15- sialic acid and calcium channel hydroxyarachidonic acid in aorta ligands S/77 279 TXA2/PGH2 receptors 537 Atropine Aprindine affinity at cloned muscarinic effect on palytoxin-induced catechol- receptors 1645 amine secretion 17 effect on muscarinic receptors in PaaSRaO*n i Y si ni s 9$-D-Arabinofuranosyladenine diabetic rat prostate S113 effect on ATP in erythrocytes 1/767 13-Azapinane TXA2 analogues 1B-D-Arabinofuranosylcytosine TXA2/PGH2 receptor subclasses 537 5-fluorouracil interaction in colon 8-Azidoadenosine cancer cells 409 effect on formycin B transport by metabolism and cytotoxicity in macrophages 247 aPeNegPRe e a ts leukemia cells, effect of 3'-Azido-3'-deoxythymidine bryostatin 1 853 exposed Hg cells, thymidine and BIOCHEMICAL PHARMACOLOGY 3'-Azido-3'-deoxythymidine(contd. ) Bile flow AZT metabolism in 905 effect of colchicine and carbon glucuronidation by human liver 559 tetrachloride 2323 effect on PC12 cells R5 Bilirubin effect of probenecid and acetamino- in serum, effect of cyclosporin A phen on catabolism in hepato- 2053 cytes 1475 Bilirubin dimethylester toxic effects in male rat 1293 glutathione conjugates 1969 m-Azidopyrimethamine 2',2'-Bipyridyl effect on keratinocytes S39 plus desferrioxamine, effect on Plasmodium falciparum 1633 B859-35 2',/7'-Bis(2-carboxyethyk)-5(6)- cancer therapy 1511 carboxyfluorescein Bacitracin efflux from intestinal epithelial DNA base damage 1595 cells S33 Bay K 8644 1,3-Bis(2-chloroethyl )-l-nitrosourea cardiovascular activity, effect of inhibition of S6 kinase activation neuraminidase S//7 . by growth factors 553 Bemoradan Bis(p-nitrop)h pheonspyhalte cardiac phosphodiesterase inhibitor inhibition of carboxylesterases 679 1335 Benfluron N,N'-Bis(2-pyridylmethylene)-1,4- effect on respiratory processes in butanediammine(N,N',N'N'''''/')F- tumour cells S214 Cu(I1I)-diperchlorate Benoxaprofen induced oxidative stress, effect of cytochrome P450 induction and glutathione 1821 peroxisomal proliferation 109 Bleomycin Benzaldehyde cytotoxicity on electropermeabilized role in toluene neurotoxicity 879 cells S67 1,2-Benzanthracene DNA degradation, effect of flavon- effect on hepatocytes cultured with oids 1673 dimethyl sulphoxide S17 induced lung fibrosis, effect of Benzene derivatives taurine + niacin 1115 induction of cytochrome P450 iso- Bleomycin hydrolase enzymes in liver S143 in lung and skin, mouse strain Benzimidazole E3810 differences 195 inhibition of gastric acid secretion, Bombesin effect of glutathione 321 mediator of neoplasia 1511 Benzoate Bone marrow inhibition of gluconeogenesis and effect of AZT 1293 ureagenesis 645 Bradykinin Benzocaine metabolizing enzymes in mesenteric action at calcium channels 213 arterial bed perfusate 1897 Benzodiazepines stimulation of competent 3T3 cells carbamazepine after alprazolam 117 discontinuation S99 Bradykinin analogues Benzo(a)pyrene metabolism by plasma aminopeptidase interaction with cytochrome P450c Pee and NADPH-cytochrome P450 Brain reductase 97 effect of 3-amino-1,2,4-triazole on Benzphetamine N-demethylase catalase activity 699 in liver microsomes effect of antidepressants on GABAp effect of interferonax 311 and B-adrenoceptors 1525 effect of methapyrilene 1093 chick embryo, effect of ethanol 223 (4-Benzyl )-phenoxy-2-morpholinium chicken, altered calmodulin kinase ethane chloride II after organophosphate treat- interaction with membrane phospho- ment 171 lipids 2099 ethanol effects on synaptosomal Beta-blockers calcium, phosphatidylinositol and free radical scavenging and inhibit- phosphatidylcholine 39 ion of lipid peroxidation 735 fish oil and oxygen toxicity 1353 Bezafibrate flavin-containing monooxygenase in effect on hepatic microsomal electron 442 transport chains 2057 effect of halothane on adenosine Al Bile and 5-HTj,q receptors 1313 arsenic excretion 465 histidine decarboxylase in 217 polyethylene glycol excretion 1775 5-HT» receptor regulation 1099 Bile acids effect of 1-methyl-4-phenyl-2,3- in serum, effect of cyclosporin A dihydropyridinium and l-methyl-4- 2053 phenylpyridinium on mitochondrial uptake in hepatocytes, effect of function 913 amiloride and 4,4'-diisothiocyano- monoamine oxidase A inhibition by 2,2'-disulfonic stilbene $135 neurocatin 2351 BIOCHEMICAL PHARMACOLOGY Brain(contd. ) Buthionine sulphoximine(contd. ) morphine effect on monoamine effect on perfluoroisobutene induced metabolism 1107 pulmonary edema S47 morphine inhibition of noradrenaline Butylated hydroxytoluene release $121 effect on membrane fluidity 1587 effect of morphine tolerance-depend- ence and abstinence on k-opiate receptors 1302 Cadmium Na* efflux from membrane vesicles hepatotoxicity, effect of ethanol S9 1811 effect on palytoxin-induced catechol- nitric oxide synthase in 1849 amine secretion 1/7 K-Opiate receptor down-regulation Cadralazine 25 effect on myeloperoxidase 1844 T-2 toxin metabolism 949 Caffeic acid Breast cancer antioxidative activity 11/77 7,12-dimethylbenz() anthracene Calcium induced, amine oxidases in 263 binding to dipalmitoyl phosphatidic Breast cancer cells MCF-7 acid films, effect of cationic drug resistance in vivo 391 amphiphilic compounds S6l menadione-induced DNA damage 1961 in CHO cells, effect of l-methyl-2- effect of triphenylethylene derivat- nitrosoimidazole 2153 ives on progesterone and estrogen effect on dopamine receptor agonist receptors 1837 binding in pituitary and 73l5a Breast tumour transplants tumours 2163 5-fluorouracil incorporation into homeostasis in hepatocytes, effect RNA and inhibition of thymidine of menadione 1977 kinase 2367 influx in chromaffin cells Bredinin effect of brovincamine 190 effect on ATP in erythrocytes 1/767 effect of imidazole-receptor Brij 58 binding agents 2011 activation of morphine-UDP-glucur- effect of palytoxin 17 onosyltransferase in liver S55 in LLC-PK} cells, ATP-induced Bromobenzoylmethyladamantylamine changes 1495 effect on agonist induced atrial in lung, effect of taurine + niacin Rb efflux 655 on bleomycin-induced increase Bromodeoxyuridine 1115 incorporation into DNA in colorectal mobilization in chick embryos, tumour cells 131 effect of ethanol 223 p-Bromophenacyl bromide in multidrug resistant ovarian ~ inhibition of adenylate cyclase 194] cancer cells 1427 N-Bromosuccinimide in neutrophils and monocytes, effect effect on zacopride binding in of cytochalasin B 425 NG108-15 cells 1453 receptor activated inflow system in Brovincamine hepatocytes 2239 effect on catecholamine secretion release from gastric parietal cells, from adrenal medullary cells 190 effect of muscarinic agonists and Brush border membrane vesicles antagonists 839 partition coefficients 2259 release from kidney mitochondria, Bryostatin 1 effect of cyclosporin A 2193 effect on ara-C metabolism and role in cytotoxicity of topoisomerase cytotoxicity 853 inhibitors 7/7 Bucillamine role in penicillamine-enhanced PMN effect on glutathione metabolism in locomotion 1745 mice 84/7 role in stimulus-induced cyclic AMP Buformin hydrochloride elevation in neutrophils $105 effect on conformations of poly-L- role in W7 stimulation of Kt trans- lysine 2397 port in human epithelia 1039 P-Bungarotoxin sequestration in liver, effect of effect on cross-linking of presyn- ryanodine 1799 aptic plasma membrane proteins synaptosomal uptake 2043 effect of ethanol 39 Bunitrolol 4-hydroxylase effect of manganese 1537 in liver of Dark Agouti and Wistar in vas deferens smooth muscle cells, rats 2241 effect of histamine 1545 Bupivacaine Calcium channel blockers action at calcium channels 213 cancer chemotherapy 1514 Butacaine effect on catecholamine secretion action at calcium channels 213 by chromaffin cells 190 Buthionine sulphoximine free radical scavenging and effect on melphalan resistance inhibition of lipid peroxidation in vitro and in vivo 439 735 effect on e-naphthylisothiocyanate- effect on palytoxin-induced catechol- induced liver injury 1181 amine secretion 17

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