Bioactive Natural Products: Chemistry and Biology PDF
Preview Bioactive Natural Products: Chemistry and Biology
Editedby GoutamBrahmachari BioactiveNaturalProducts RelatedTitles Brahmachari,G. Osbourn,A.,Goss,R.J.,Carter,G.T. HandbookofPharmaceutical NaturalProducts NaturalProducts Discourse,Diversity,andDesign 2010 2014 PrintISBN:978-3-527-32148-3 PrintISBN:978-1-118-29806-0(Alsoavailableina varietyofelectronicformats) Hanessian,S.(ed.) Civjan,N.(ed.) NaturalProductsinMedicinal NaturalProductsinChemical Chemistry Biology 2014 PrintISBN:978-3-527-33218-2(Alsoavailableina 2012 varietyofelectronicformats) PrintISBN:978-1-118-10117-9(Alsoavailableina varietyofelectronicformats) Kim,S.(ed.) Tang,W.,Eisenbrand,G. MarineMicrobiology HandbookofChinese BioactiveCompoundsand BiotechnologicalApplications MedicinalPlants Chemistry,Pharmacology,Toxicology 2013 PrintISBN:978-3-527-33327-1(Alsoavailableina 2011 varietyofelectronicformats) PrintISBN:978-3-527-32226-8 Editedby GoutamBrahmachari Bioactive Natural Products ChemistryandBiology TheEditor AllbookspublishedbyWiley-VCHare carefullyproduced.Nevertheless,authors, Prof.Dr.GoutamBrahmachari editors,andpublisherdonotwarrantthe Visva-BharatiUniversity informationcontainedinthesebooks, DepartmentofChemistry includingthisbook,tobefreeoferrors. Santiniketan732235 Readersareadvisedtokeepinmindthat India statements,data,illustrations,procedural detailsorotheritemsmayinadvertently beinaccurate. LibraryofCongressCardNo.:appliedfor BritishLibraryCataloguing-in-Publication Data Acataloguerecordforthisbookis availablefromtheBritishLibrary. Bibliographicinformationpublishedbythe DeutscheNationalbibliothek TheDeutscheNationalbibliothek liststhispublicationintheDeutsche Nationalbibliografie;detailed bibliographicdataareavailableonthe Internetat<http://dnb.d-nb.de>. ©2015Wiley-VCHVerlagGmbH&Co. KGaA,Boschstr.12,69469Weinheim, Germany Allrightsreserved(includingthoseof translationintootherlanguages).Nopart ofthisbookmaybereproducedinany form–byphotoprinting,microfilm, oranyothermeans–nortransmitted ortranslatedintoamachinelanguage withoutwrittenpermissionfromthe publishers.Registerednames,trademarks, etc.usedinthisbook,evenwhennot specificallymarkedassuch,arenottobe consideredunprotectedbylaw. PrintISBN:978-3-527-33794-1 ePDFISBN:978-3-527-68441-0 ePubISBN:978-3-527-68442-7 MobiISBN:978-3-527-68443-4 oBookISBN:978-3-527-68440-3 Typesetting LaserwordsPrivateLimited, Chennai,India PrintingandBinding MarkonoPrint MediaPteLtd,Singapore Printedonacid-freepaper Allthosewhoareworkinggloballywithbioactivenaturalproductsforthecauseof humanwelfare XI Contents Foreword VII Preface XXI AbouttheEditor XXV ListofContributors XXVII 1 AnOverview 1 GoutamBrahmachari 2 UseofChemicalGenomicstoInvestigatetheMechanismofAction forInhibitoryBioactiveNaturalCompounds 9 DanielBurnside,HoumanMoteshareie,ImeldaG.Marquez, MohsenHooshyar,BahramSamanfar,KristinaShostak,KatayounOmidi, HarryE.Peery,MyronL.Smith,andAshkanGolshani 2.1 Introduction:AntibioticResistanceandtheUseofNaturalProducts asaSourceforNovelAntimicrobials 9 2.2 ChemicalGeneticsandGenomics 10 2.3 DevelopmentofGDATechnology 11 2.3.1 TheUseofGeneDeletionArrays(GDAs)toInvestigate MOA 12 2.3.2 ChemicalGeneticInteractions 12 2.3.3 QuantifyingGeneticandChemicalGeneticInteractions 14 2.3.4 DataAnalysis 15 2.3.5 PlatformsforChemicalGenomicGDAStudies 17 2.3.6 WhyScreenNaturalProductsinGDAs? 19 2.3.7 SuccessfulApplicationsofGDATechnology 21 2.4 ConcludingRemarks 22 Abbreviations 24 References 24 XII Contents 3 High-ThroughputDrugScreeningBasedonCancerSignaling inNaturalProductScreening 33 XinxinZhang,YupingDu,andJinboYang 3.1 Introduction 33 3.2 CancerSignalingPathwayswithTheirOwnDrugScreeningAssays inHTS 35 3.2.1 β-GalactosidaseEnzymeComplementationAssaysforEGFR SignalingDrugScreening 35 3.2.2 FluorescenceSuperquenchingAssaysforPI3KsSignalingDrug Screening 35 3.2.3 TOPFlashReporterGeneAssaysforWntSignalingDrug Screening 36 3.2.4 LuciferaseReporterGeneAssaysforSTATsSignalingDrug Screening 37 3.3 ConcludingRemarks 37 Abbreviations 38 References 38 4 Immunosuppressants:RemarkableMicrobialProducts 43 PreetiVaishnav,YoungJ.Yoo,YeoJ.Yoon,andArnoldL.Demain 4.1 Introduction 43 4.2 Discovery 44 4.3 ModeofAction 47 4.4 Biosynthesis 49 4.4.1 Acetate,Propionate,Butyrate,Methionine,andValineas PrecursorsoftheMacrolideRingsofSirolimus,Ascomycin,and Tacrolimus 49 4.4.2 PipecolateMoietyoftheMacrolideRingofSirolimus, Ascomycin,andTacrolimus 52 4.4.3 TheFinalStepinBiosynthesisofAscomycinsand Tacrolimus 55 4.4.4 FormationoftheSubstitutedCyclohexylMoietyofSirolimus, Tacrolimus,andAscomycins 58 4.4.5 BiosynthesisofCyclosporin 61 4.5 GeneticsandStrainImprovement 63 4.6 FermentationandNutritionalStudies 65 4.7 OtherActivitiesofImmunosuppressants 69 4.8 ConcludingRemarks 71 Acknowledgments 72 References 72
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