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BIOACTIVE-LOADED NANOMEDICINE FOR THE MANAGEMENT OF HEALTH AND DISEASE BIOACTIVE-LOADED NANOMEDICINE FOR THE MANAGEMENT OF HEALTH AND DISEASE Edited by Mahfoozur Rahman, PhD Sarwar Beg, PhD Khalid S. Alharbi, PhD Waleed Hassan Almalki, PhD Nabil K. Alruwaili, PhD Majed Al Robaian, PhD First edition published 2023 Apple Academic Press Inc. CRC Press 1265 Goldenrod Circle, NE, 6000 Broken Sound Parkway NW, Palm Bay, FL 32905 USA Suite 300, Boca Raton, FL 33487-2742 USA 760 Laurentian Drive, Unit 19, 4 Park Square, Milton Park, Burlington, ON L7N 0A4, CANADA Abingdon, Oxon, OX14 4RN UK © 2023 by Apple Academic Press, Inc. Apple Academic Press exclusively co-publishes with CRC Press, an imprint of Taylor & Francis Group, LLC Reasonable efforts have been made to publish reliable data and information, but the authors, editors, and publisher cannot assume responsibility for the validity of all materials or the consequences of their use. 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For works that are not available on CCC please contact [email protected] Trademark notice: Product or corporate names may be trademarks or registered trademarks and are used only for identification and explanation without intent to infringe. Library and Archives Canada Cataloguing in Publication Title: Bioactive-loaded nanomedicine for the management of health and disease / edited by Mahfoozur Rahman, PhD [and five others]. Names: Rahman, Mahfoozur, 1984- editor [and five others]. Description: First edition. | Includes bibliographical references and index. Identifiers: Canadiana (print) 20220274177 | Canadiana (ebook) 20220274223 | ISBN 9781774639931 (hardcover) | ISBN 9781774639948 (softcover) | ISBN 9781003277101 (ebook) Subjects: LCSH: Nanomedicine. | LCSH: Bioactive compounds. Classification: LCC R857.N34 B56 2023 | DDC 610.28—dc23 Library of Congress Cataloging-in-Publication Data CIP data on file with US Library of C o ngress ISBN: 978-1-77463-993-1 (hbk) ISBN: 978-1-77463-994-8 (pbk) ISBN: 978-1-00327-710-1 (ebk) About the Editors Mahfoozur Rahman, PhD Assistant Professor, Department of Pharmaceutical Sciences, Faculty of Health Science, Sam Higginbottom University of Agriculture, Technology and Sciences (SHUATS), Allahabad, Uttar Pradesh, India Mahfoozur Rahman, PhD, is an Assistant Professor in the Department of Pharmaceutical Sciences, Faculty of Health Science at the Sam Higginbottom University of Agricul ture, Technology and Sciences (SHUATS), Allahabad, India. His major areas of research interest include the development and characterization of nanosized drug delivery systems for inflammatory disorders, including psoriasis, arthritis, neurodegenerative disorders, cancer, etc. In addition, he is also working on the amalgamation of herbal medicinal plants with modern therapeutics in order to deliver a scientifically acceptable therapy for various diseases management. To date, he has published articles in various reputed journals, including Seminar in Cancer Biology, Drug Discovery Today, Drug Delivery, Expert Opinion on Drug Delivery, Nanomedicine, etc. He has 40 book chapters and seven international books in various reputed publishers. Overall, he has earned a highly impressive publishing and cited record in Google Scholar (H-index of 32, total citation: 3100, and Scopus H index 28). Sarwar Beg, PhD Assistant Professor, Department of Pharmaceutics, School of Pharmaceutical Education and Research (SPER), Jamia Hamdard (Hamdard University), New Delhi, India Sarwar Beg, PhD, is currently serving as an Assistant Professor in the Department of Pharmaceutics, School of Pharmaceutical Education and Research (SPER) at the Jamia Hamdard (Hamdard University), New Delhi, India. He has nearly a decade of experi ence in systematic development and characterization of novel and nanostruc tured drug delivery systems using QbD paradigms like design of experiments (DoE) and quality risk management (QRM). He has published over 150 vi About the Editors review/research articles in peer-reviewed journals, 45 book chapters, 12 books, 10 special journal issues, three Indian patent applications, and a score of conference presentations with a cumulative impact factor 320, Google Scholar H-index of 24 (i10 index 61), and over 2,500 citations to his credit, quite unparalleled for a young scientist of his age. For his immense research prowess and contributions to the field, Dr. Sarwar has received several young scientist awards at various national and international forums, including SIPRA Innovative Pharma Research Award 2016 and Bronze Medal (by SIPRA Labs, Hyderabad); Eudragit Award 2015 in South Asia (by Evonik GmbH, Germany); Budding QbD Scientist Award 2014, Budding ADME and Toxicology Scientist Award 2013 (by Select Biosciences, UK); and Novartis Biotechnology Leadership Camp Award 2012 (by Novartis, Hyderabad). Dr. Sarwar has also received a score of best paper awards” at several scientific forums, including the 65th Indian Pharmaceutical Congress in 2014 along with the prestigious Prof. M. L. Khorana Memorial Best Paper Award 2013 by Kongposh Publications, New Delhi, and Dr. P. D. Sethi Best Paper Award 2017 by the Indian Pharmaceutical Association, Mumbai. In 2017, Dr. Sarwar was felicitated by the Honorable Health Minister of India and Managing Director of Sun Pharmaceutical Industries, with the prestigious Sun Pharma Science Foundation-Young Science Scholar Award for his research contri butions in the field of pharmaceutical sciences. In May 2019, he was also selected for the UGC Young Scientist Award for his research achievements. Khalid S. Alharbi, PhD Assistant Professor, Department of Pharmacology, College of Pharmacy, Jouf University, Sakakah, Saudi Arabia Khalid S. Alharbi, PhD, is an Assistant Professor in department of Pharmacology and Toxicology, College of Pharmacy, Jouf University, Sakaka, Saudi Arabia. He obtained both his BSc (Pharmaceutical Sciences, 2002) and MSc (Toxicology, 2009) at the College of Pharmacy at King Saud University (KSU), Riyadh, Saudi Arabia. He was awarded his PhD (Pharmacy and Biomedical Sciences, 2016) from Strathclyde University, United Kingdom. Dr. Alharbi’s major area of research is cancer, including drug discovery, nanomedicine, and preclinical pharma cological and toxicological studies of anticancer agents. He has published several articles in peer-reviewed journals and presented papers at numerous international conferences. About the Editors vii Waleed Hassan Almalki, PhD Professor of Pharmacology, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia Waleed Hassan Almalki, PhD, is an Associate Professor of Pharmacology at the College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia. He earned his doctoral degree at the University of Glasgow, United Kingdom, having a dissertation on ocular pharmacology. His current research is focused on the broad areas of host-virus networks in hepacivirus C disease progression as well as host- virus genes expression during oxidative stress, hepatic steatosis, fibrosis, and hepatocellular carcinoma. He is also enthusiastically involved in the studies of tyrosine kinase inhibitors for the treatment of breast and colon cancer, in the Saudi population. Dr. Almalki has published many research and review articles in peer-reviewed international journals on HCV pathogenesis, treat ment, and drug designing, as well as edited various book chapters about angiogenesis, pharmacological assays, and infectious disease epidemiology. Nabil K. Alruwaili, PhD Assistant Professor, Pharmaceutics Department, School of Pharmacy, Jouf University, Sakaka, Saudi Arabia Nabil K. Alruwaili, PhD, is an Assistant Professor of Phar maceutics Department at the School of Pharmacy, Jouf University, Sakaka, Saudi Arabia. Previously, Dr. Alruwaili worked at SFDA in product evaluation and standards-setting administration Riyadh, KSA, for three years. He has good experience in assessment and registration dossiers submitted by companies for a variety of pharmaceutical products. There are many aspects to be assessed in such files, including drug master file (DMF), which involve drug design and manufacturing. Dr. Alruwaili is effective in building successful projects through open channels of communication and synergistic relationships across research disciplines in order to motivate others on all levels in the achievement of individual and organizational goals. He has several published articles and has presented papers at international and national scientific conferences. He obtained both his BSc (Pharmaceutical Sciences, 2008) and MSc (Quality Control of Pharmaceutic, 2011) from the College of Pharmacy at King Saud University (KSU), Riyadh, Saudi Arabia. He was awarded his PhD (Pharmceutics, 2017) from MCPHS University, USA. viii About the Editors Majed Al Robaian, PhD Dean, Faculty of Pharmacy, Taif University in Saudi Arabia Majed Al Robaian, PhD, is the Dean of the Faculty of Pharmacy at Taif University in Saudi Arabia. He obtained his BSc from King Saud University in Riyadh, Saudi Arabia, and his MSc in Pharmaceutical Sciences from Strathclyde University in the United Kingdom in 2010, and his PhD from the same university in 2014. His research interests focus on drug delivery and, in particular, the delivery of therapeutic genes for the treatment of cancer. Before obtaining his PhD, he worked as Director of Pharmacy at King Abdu laziz Hospital. Currently, he is appointed as the Science Faculty Ambassador for Strathclyde University. He is a member of a number of committees in the Saudi Commission for Health Specialties. Contents Contributors .............................................................................................................xi Abbreviations .......................................................................................................... xv Preface ................................................................................................................... xxi PART I: Bioactive-Loaded Nanomedicine as Anticancer Potential ...................1 1. Phyto-Actives and Their Targeted Action in Management of Hepatocellular Carcinoma: Scope of Nanomedicine in Its Effective Delivery .......................................................................................3 Mahfoozur Rahman, Kainat Alam, Khalid S. Alharbi, Waleed Hassan Almalki, Nabil K. Alruwaili, Sarwar Beg, and Shipra Daniel 2. Thymoquinone-Loaded Nanomedicines for Triple-Negative Breast Cancer Treatment ...............................................................................17 Md. Abul Barkat, Harshita, Anjali Goyal, Md. Sarfaraj Hussain, Sarwar Beg, Mahfoozur Rahman, Khalid S. Alharbi, and Farhan J. Ahmad 3. Nucleic Acid-Loaded Nanomedicines with Enhanced Anticancer Potential .....................................................................................37 Behiye Şenel and Gülay Büyükköroğlu 4. Breast Cancer Therapy by Combinatorial Herbo-Synthetic Nanocarrier....................................................................................................61 Bharti Mangla, Pankaj Kumar, Kamya Goyal, Kanchan Kohli, and Shammy Jindal PART II: Phytoactives-Loaded Nanocarriers as Antipsychotic and Antimanic Potential ......................................................................................87 5. Antipsychotics and Antimanics: An Insight into Mechanism of Action of Natural Compounds ............................................89 Partha Pratim Das, S. K. Batin Rahaman, Md. Adil Shaharyar, Mahfoozur Rahman, Kainat Alam, Imran Kazmi, Kumar Anand, Monalisha Sengupta, Sasmita Dash, and Sanmoy Karmakar 6. Plant-Derived Anti-Psychotic Drugs: An Insight into Receptor and Phytoconstituent Interaction .............................................. 111 Partha Pratim Das, S. K. Batin Rahaman, Md. Adil Shaharyar, Rudranil Bhowmik, Avishek Mandal, and Sanmoy Karmakar 7. Plant Bioactive Compounds and Their Nanoformulations for the Treatment of Alzheimer’s Disease .......................................................139 Dhara Lakdawala and Farhan J. Ahmad