ebook img

Bile Acid Biology and Therapeutic Actions Abstracts Poster Abstracts PDF

193 Pages·2008·0.81 MB·English
by  
Save to my drive
Quick download
Download
Most books are stored in the elastic cloud where traffic is expensive. For this reason, we have a limit on daily download.

Preview Bile Acid Biology and Therapeutic Actions Abstracts Poster Abstracts

Falk Symposium 165 XX International Bile Acid Meeting Bile Acid Biology and Therapeutic Actions June 13–14, 2008 Hotel Okura Amsterdam, The Netherlands Abstracts Poster Abstracts FALK FOUNDATION e.V. Leinenweberstr.5 79108Freiburg Germany www.falkfoundation.com ©2008FalkFoundatione.V. Allrightsreserved. AbstractsofInvitedLectures PosterAbstracts FalkSymposium165 XXInternationalBileAcidMeeting BILEACIDBIOLOGYAND THERAPEUTICACTIONS Amsterdam(TheNetherlands) June13–14,2008 President: P.L.M.Jansen,Amsterdam(TheNetherlands) ScientificOrganization: D.Keppler,Heidelberg(Germany) U.Beuers,Amsterdam(TheNetherlands) A.Stiehl,Heidelberg(Germany) M.Trauner,Graz(Austria) CONTENTS page SessionI Metabolismandtransportofbileacids Chair: C.A.Einarsson,Huddinge J.Sjövall,Stockholm Membraneasymmetryandtheregulationofbileformation R.P.J.OudeElferink,Amsterdam 23–24 ABCB11(BSEP)activityisdependentonthecanalicular membranecholesterolcontent C.C.Paulusma,Amsterdam 25 Fic1deficientrathepatocytesrevealstructuralandfunctional defectsinthebilecanalicularmembranewhenexposed tohydrophobicbileacids J.L.Boyer,NewHaven 26 Bileacidsandthebrain.Suggestedpathogeneticmechanism inconnectionwithformationofbrainxanthomasinpatients withCTX I.Björkhem,Huddinge 27 SessionII Transportofbileacids Chair: P.A.Dawson,Winston-Salem D.Keppler,Heidelberg Canalicularmicrodomainsandbileformation B.Stieger,Zurich 31 Regulationofthecellsurfaceexpressionandtransport capacityofBSEPbysmallchemicalmolecules H.Hayashi,Tokyo 32 3 TheroleofABCB11(BSEP)variationinsusceptibilityto intrahepaticcholestasisofpregnancy P.H.Dixon,London 33 Intracellulartransportofbilesalts K.N.Faber,Groningen 34 Conjugatedbileacidsregulatehepaticgluconeogenicgenes viaGαiproteincoupledreceptor(s)intheliver P.B.Hylemon,Richmond 35 SessionIII Transportandactionsofbileacids Chair: W.Kramer,Frankfurt F.J.Suchy,NewYork RoleoforganicsolutetransporterOSTα-OSTβinintestinal basolateralbileacidtransportandhomeostasis P.A.Dawson,Winston-Salem 39 Mechanismofregulationofbileacidtransportinthesmall intestine H.Suzuki,Tokyo 40 Expressionandlocalizationofthemembrane-boundbileacid receptorTGR5inhumangallbladdertissue V.Keitel,Düsseldorf 41 Bilesaltscontroltheantibacterialpeptidecathelicidinthrough nuclearreceptorsinhumanbiliaryepithelialcells N.Chignard,Paris 42 Chair: P.L.M.Jansen,Amsterdam G.A.Kullak-Ublick,Zurich FromGlarustoGallenfarbstoffen:Thescientificcontributions ofRudiSchmid(Noabstract) A.F.McDonagh,SanFrancisco 4 SessionIV Nuclearreceptorregulation Nuclearreceptorregulationofbileacidtransporters G.A.Kullak-Ublick,Zurich 45–46 OrphannuclearreceptorLXRinbileaciddetoxificationand cholestasis W.Xie,Pittsburgh 47 ThenuclearhormonereceptorERalphaplaysacriticalrole indeterminingestrogen-inducedcholesterolgallstones D.Q.-H.Wang,Boston 48–49 RoleofintestinalnuclearbileacidreceptorFXRinthegut-liver axis A.Moschetta,Bari 50 SessionV Bileacidsasmetabolicintegrators Chair: A.F.Hofmann,SanDiego M.Trauner,Graz LRH-1andcontrolofbileacidhomeostasis K.Schoonjans,Illkirch 53 Differentialeffectsofursodeoxycholicacid(UDCA)and side-chain-shortenednorUDCAinthetreatmentoffatty liverandatherosclerosis M.Trauner,Graz 54 Side-chain-modificationcriticallydeterminesthephysiologicand therapeuticpropertiesof24-nor-ursodeoxycholicacidinthe treatmentofsclerosingcholangitisinMdr2(Abcb4)knock-out miceandisolatedbileductunits E.Halilbasic,Graz 55 Roleofsidechainamidationfortheanticholestaticactionof norUDCAinratliver U.Beuers,Amsterdam 56 PresentationoftheAdolfWindausPrize G.Paumgartner,Munich 5 AdolfWindausPrizeLecture OSTα-OSTβasapotentialtherapeutictargetforaltering bileacidandlipidlevels N.Ballatori,Rochester,NY 57–58 SessionVI Bileacids:Cellularinjuryandregeneration Chair: D.Häussinger,Düsseldorf R.Poupon,Paris Acrobaticliverstemcells:Roleincellularinjuryand regeneration T.Roskams,Leuven 61–62 Pro-andantiapoptoticactionsofbileacidsandCD95ligand inhepaticstellatecells D.Häussinger,Düsseldorf 63–64 SuccessfulreactivationofhepaticMrptransportersinendotoxin inducedcholestasisinmicebytheCARactivator6,7-dimethyl- esculetin I.V.Martin,Aachen 65 Neuropeptides,neuroendocrinehormonesandbileacid interactionsincholangiocyteresponsetoinjury A.Benedetti,Ancona 66 SessionVII Bileacid-relatedgeneticliverdisease Chair: G.P.vanBergeHenegouwen,Utrecht H.-U.Marschall,Huddinge ThemanyfacesofMDR3deficiency P.L.M.Jansen,Amsterdam 69–71 Severebilesaltexportpumpdeficiency:Mutations, immunohistochemistryandmalignancyrisk S.Strautnieks,London 72–73 6 Roleofgeneticsindrug-inducedcholestasis C.Pauli-Magnus,Basel 74 Variabilityofcholestaticliverdiseaseinafamilywith 11siblingsandanABCB4defect D.Gotthardt,Heidelberg 75 ABCG5/G8asahumanriskgeneforcholesterolgallstone disease F.Lammert,Homburg/Saar 76–77 ATP8B1functionandpossibletherapeuticinterventions R.H.J.Houwen,Utrecht 78 Bileacidabnormalitiesinperoxisomaldisorders S.Ferdinandusse,Amsterdam 79 SessionVIII Bileacidsastherapeuticagents Chair: R.W.Chapman,Oxford G.Paumgartner,Munich UrsodeoxycholicacidforPSC–Anupdate K.D.Lindor,Rochester,MN 83 Excellentlong-termsurvivalinpatientswithprimarybiliary cirrhosistreatedwithursodeoxycholicacid A.Parés,Barcelona 84–85 High-doseUDCAforthetreatmentofNASH:Resultsofa multicentertrial(Noabstract) U.Leuschner,Frankfurt IntravenoususeofSUDCA(ursodeoxycholicdisulfate)– Aunidirectionalbileacid,forhepatoprotectioninliver transplantationandTPN-associatedcholestasis K.D.R.Setchell,Cincinnati 86–88 Features,prognosisandmanagementofPBCintheera ofUDCAandbudesonide R.Poupon,Paris 89–90 ListofSpeakers,ModeratorsandScientificOrganizers 91–95 7 PosterAbstracts IMetabolismandtransportofbileacids 1. Sulphatedprogesteronemetabolitesinterferewithprimaryhumanhepatocyte bileacidtransport S.Abu-Hayyeh,C.Selden,M.R.Romero,H.-U.Marschall,M.Rees,R.White, C.Williamson(London,GB;Huddinge,S;Basingstoke,GB) 2. BiliaryandfaecalbileacidprofilesinducedbyLarreatridentatainhamster S.Arteaga,R.Cárdenas(Mexico,MEX) 3. ThehydrophobiciminosugarAMP-DNMincreasesbiliarylipidsecretionin C57BL/6miceviaFGFmediatedregulationofCYP7A1 N.Bijl,R.Ottenhoff,C.P.A.A.Roomen,S.Scheij,J.M.F.G.Aerts,A.K.Groen (Amsterdam,NL) 4. Formationofbilecanaliculiandextracellularmatrix(ECM)-cellcontacts D.Cassio,S.Kassar,D.Jaillard,J.Degrouard,B.Grosse(Orsay,F) 5. Fastmethodstomeasureamidatedbileacidsinlivertransplantpatients: MS/MScharacterizationofside-chainanalogfluorescentderivatives H.E.Ferreira,J.Barbosa,H.Vilca-Melendez,N.D.Heaton,J.C.M.Bordado (Lisbon,P;London,GB) 6. TransportofsulphatedbileacidsbycanalicularABCG2 A.G.Blazquez,O.Briz,M.R.Romero,R.Rosales,P.Martinez-Becerra, C.Ghanem,M.A.Serrano,J.J.G.Marin(Salamanca,E;BuenosAires,RA) 7. Thebileacidsandbilealcoholsofbirds:Evolutiongivesrisetoadazzling varietyofstructures L.R.Hagey(LaJolla,USA) 8. Theevolutionofbilesaltsinvertebrates:Newfindings L.R.Hagey(LaJolla,USA) 9. Alteredbileacidmetabolisminchildhoodfunctionconstipation:Inactivationof secretorybileacidsbysulfationinasubsetofpatients A.F.Hofmann,V.Loening-Baucke,J.Lavine,L.R.Hagey,J.Steinbach, C.Packard,T.Griffin,D.Chatfield(LaJolla,IowaCity,SanDiego,USA) 10. Increasedserum27-hydroxycholesterolconcentrationindicatesanactivationof LXRαandanexcessofcholesterolinthehumanbody A.Honda,T.Ikegami,M.Shirai,T.Hara,Y.Homma,Y.Matsuzaki (Ami,Mito,Isehara,J) 9 11. ACAT2andhumanhepaticcholesterolmetabolism:Identificationofimportant gender-relateddifferences Z.Y.Jiang,P.Parini,C.A.Einarsson,G.Eggertsen,M.A.Davis,S.-D.Zhang, L.L.Rudel,T.-Q.Han,L.Eriksson(Huddinge,S;Winston-Salem,USA; Shanghai,RC) 12. Isolation,identification,andchemicalsynthesisofnovelbileacidsinvertebrates G.Kakiyama,T.Iida,A.Muto,N.Mano,J.Goto,L.R.Hagey,A.F.Hofmann (Tokyo,Sendai,J;LaJolla,USA) 13. Hepaticcytochromep450oxidoreductaseknockoutmicehavealteredbile formation C.Kunne,D.R.deWaart,C.C.Paulusma,R.P.J.OudeElferink (Amsterdam,NL) 14. Degradationof24S-hydroxycholesterolinmanisnotregulatedbyCyp7A1 D.Lütjohann,C.Knabe,T.Sudhop,K.vonBergmann(Bonn,D) 15. Metabolismofside-chainmodifiedursodeoxycholicacidinMdr2-/-mice H.-U.Marschall,E.Halibasic,P.Fickert,T.Moustafa,M.Wagner,G.Zollner, M.Trauner(Huddinge,S;Graz,A) 16. Analysisoflithocholicacid-taggedproteinsintheratliverbyusing immunoaffinitycaptureandMALDI-TOFMS S.Ikegawa,T.Yamamoto,K.Mitamura(Higashi-Osaka,J) 17. Mechanisticstudiesontheformationofacylglutathioneconjugateofbileacidin ratliveranditsbiliaryexcretion K.Mitamura,S.Watanabe,Y.Mitsumoto,T.Sakai,M.Sogabe,T.Wakamiya, S.Ikegawa(Higashi-Osaka,J) 18. Structure-activityrelationshipsofAKR-typeoxidoreductasesinvolvedinbile acidsynthesis U.Oppermann,P.Lukacik,K.Guo,W.H.Lee,K.L.Kavanagh(Oxford,GB) 19. Unconjugatedbilesaltsshuttlethroughhepatocyteperoxisomesforglycineor taurineconjugation K.P.Rembacz,J.Woudenberg,E.Jonkers,H.Moshage,F.Stellaard, K.N.Faber(Groningen,NL) 20. IncreasingexpressionofthecholesterolbindingSTARTdomainprotein, StarD4,stimulatesratesofbileacidsynthesisandcholesterolesterformationin primarymousehepatocytes D.Rodriguez-Agudo,S.Ren,E.Wong,D.Marques,K.Redford,P.B.Hylemon, G.Gil,W.M.Pandak(Richmond,USA) 21. Bileacidsynthesisinmanrelatestoplasmatriglycerides,genderandpresence ofgallbladderbutnottoaging C.Gälman,B.Angelin,B.Thorsson,A.Bröijersen,M.Rudling(Huddinge,S; Kopavogur,IS) 10

Description:
Effects of long term hydrophilic bile acid therapy on in vitro contraction of Prague, Czech Republic Service d'Hépato-Gastro-Entérologie localization of hOST were investigated by confocal microscopy and 2Sophia Children's Hospital, Erasmus Medical Center, University of Rotterdam, The.
See more

The list of books you might like

Most books are stored in the elastic cloud where traffic is expensive. For this reason, we have a limit on daily download.