Benzodiazepines: Today and Tomorrow PDF
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Benzodiazepines Today and Tomorrow Benzodiazepines Tomorrow Today and Proceedings of the 1s t International Symposium on Benzodiazepines in Rio de Janeiro 28-30 September 1979 Edited by R.G. PRIEST Professor of Psychiatry, St. Mary's Hospital Medical School, University of London, England U. VIANNA FILHO Professor of Psychiatry, Psychiatry Institute President of Brazilian Psychiatry Association Rio de Janeiro, Brazil R. AMREIN F. Hoffmann-La Roche & Co. Ltd., Basle, Switzerland M. SKRETA F. Hoffmann-La Roche & Co. Ltd., Basle, Switzerland MT~LIMITED International Medical Publishers All names of products in this book are legally protected as Trade Marks. Published by MTP Press Limited Falcon House Lancaster, England Copyright © 1980 MTP Press Limited Softcover reprint of the hardcover 1s t edition 1 980 First published 1980 All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, without prior permission from the publishers. British Library Cataloguing in Publication Data International Symposium on Benzodiazepines, 1s f. Rio de Janeiro, 1979 Benzodiazepines today and tomorrow. 1. Benzodiazepines - Congresses I. Title II. Priest, Robert G. 615'.7882 RM666.B42 ISBN 978-94-011-7240-0 ISBN 978-94-011-7238-7 (eBook) DOI 10.1007/978-94-011-7238-7 REDWOOD BURN LIMITED Trowbridge and Esher. Contents List of Contributors and Participants IX 1 Introduction U. Vianna Filho 1 2 The benzodiazepines today and tomorrow R. G. Priest 3 3 The benzodiazepine story L. H. Sternbach 5 4 Biological basis of the therapeutic effects of benzodiazepines W. E. Haefely 19 5 Pharmacokinetics of the benzodiazepines S. A. Kaplan 47 6 Importance of pharmacokinetic data for clinical practice R. Amrein and B. Leishman 61 7 The benzodiazepines: a clinical review R. G. Priest 77 8 The psychophysiological effects of benzodiazepines V. Gentil Filho 85 9 Clinical experience with benzodiazepines in psychosomatic disorders D. Kelly 99 10 Clinical experience with benzodiazepines in neurological disorders T. R. Browne and R. G. Feldman 113 11 The use of clonazepam on patients with generalized epilepsy M. P. Lison andJ. G. Speciali 123 12 Benzodiazepines and depression J. A. Costa e Silva 131 v VI BENZODIAZEPINES TODAY AND TOMORROW 13 Benzodiazepines in masked depressions E. Azzi 143 14 Some salient clinical findings from the use of benzodiazepines in childhood and adolescence G. M. Jacobides 147 15 Some data on parenteral bromazepam J. de Souza Campos 161 16 Psychotherapy and psychopharmacotherapy W. Poldinger 167 17 Treatment of alcoholism: experience with benzodiazepines S. C. Kaim 175 18 Longterm treatment with diazepam: clinical and electroencephalographic variables D. Ladewig and E. Schwarz 187 19 Psychosocial aspects of mental health care in developing countries - the role of the benzodiazepines E. D. Busnello 203 20 Longterm treatment with anxiolytic drugs: possibilities of pharmacodependence J. R. Bueno 209 21 Comparative study of the use of benzodiazepines in a university psychiatric clinic and in public and private services O. Bastos, M. C. C. A. Martins, J. Lemos and M. A. S. L. Santos 213 22 A Brazilian contribution to benzodiazepine psychopharmacology: research on anticonvulsant therapeutics and the dependence problem J. C. Madalena 233 23 Flurazepam in insomnia A. J. M. de Paula 241 24 The use of a combination of ~-blockers and benzodiazepines in anxiety I. G. Karniol, A. E. Piedrabuena, E. G. Matos, W. A. Vilela and M. J. F. Moreira 251 CONTENTS vii 25 Clinical evaluation of the sulpiride-bromazepam combination, Ro 10-7122, for patients with a depressive-anxious syndrome M. S. Moreira and F. J. Braga de Almeida 257 Workshop A: Benzodiazepines today and tomorrow, from a pharmacological point of view Coordinated by W. E. Haefely and V. Gentil Filho Participants: R. Amrein, L. H. Sternbach, W. G. Crouthamel and L. M. Lessa 265 Workshop B : Benzodiazepines today and in the future Coordinated by R. G. Priest and J. Paprocki Participants: W. PlJldinger, J. R. Bueno and D. Kelly 271 Workshop C: Psychopharmacotherapy with benzodiazepines ~ Coordinated by W. Poldinger and A. Rubim de Pinho Participants: J. A. Costa e Silva, T. R. Browne and R. G. Priest 275 Workshop D: Social aspects of benzodiazepines therapy Coordinated by D. Ladewig and M. Levy, Jr. Participants: E. D. Busnello, S. C. Kaim and M. A. Albuquerque 277 Closing speech U. Vianna Filho 279 Index of Participants 283 Subject Index 285 List of Contributors and Participants M. A. ALBUQUERQUE J. P. BOULENGER Dept· Psiquiatria c/o Produits Roche S.A. Pontiffcia Universidade Cat6lica 52, Boulevard du Parc 90000 Porto Alegre, RS 92241 Neuilly-sur-Seine BRAZIL FRANCE J. L. ALHO FILHO F. J. BRAGA DE ALMEIDA Rua Saban) 401 apt· 102 Dept· de Psiquiatria e Psicologia 01239 Sao Paulo, SP Medica BRAZIL Fac. Ci~ncias Medicas/UNICAMP Rua Jose Theodoro Lima 44 13100 Campinas, SP R. AMREIN BRAZIL Dept. of Clinical Investigation and Development F. Hoffmann-La Roche & Co. Ltd. T. R. BROWNE CH 4002 Basle Dept. of Neurology SWITZERLAND Boston University Medical Center 80 East Concord Street Boston, Mass. 02118 E. AZZI USA Dept" Psiquiatria e Psicologia Medica Fac. Ci~ncias Medicas Rua Dr. Cesario Motta Jr. 112 J. R. BUENO 01221 Sao Paulo, SP Assoc. Bras. Psiquiatria BRAZIL Rua Paulino Fernandes 78 22270 Rio de Janeiro, RJ BRAZIL O.BASTOS Dept.o de Psiquiatria Centro de Ci~ncias da Saude E. D. BUSNELLO Univ. Federal de Pernambuco Rua Luciana de Abreu 210 aptO 602 50000 Recife, PE 90000 Porto Alegre, RS BRAZIL BRAZIL V. BOTELHO Herrera A. CORREIA Casilla de Correo 2207 SOS 111, bloco D, apt" 504 La Paz 70377 Brasilia, DF BOLIVIA BRAZIL ix x BENZODIAZEPINES TODAY AND TOMORROW J. A. COSTA E SILVA V. GENTIL FILHO Rua Getulio das Neves 22 DeptOd e Farmacologia 22461 Rio de Janeiro, RJ Inst. de Ciencias Biomedicas/USP BRAZIL Cidade Universitaria 05568 Sao Paulo, SP J. L. CROISY BRAZIL Centre Hospitalier Specialise 67170 Brumath C. H. de GOUVEIA FRANCE Roche Farmaceutica Quimica Ltda. Apartado 2549 W. G. CROUTHAMEL 1113 Lisboa Dept. of Pharmacokinetics and PORTUGAL Biopharmaceutics J. R. GRABOWSKI Hoffmann-La Roche Inc. Av. Silva Jardim 921 aptO 32 Nutley, NJ 07110 80000 Curitiba, PR USA BRAZIL J. H. DIAZ W. E. HAEFELY Edificio del Banco de America Pharmaceutical Research Dept. 3ero piso F. Hoffmann-La Roche & Co. Ltd. Panama Ciudad CH 4002 Basle PANAMA SWITZERLAND A. J. M. DE PAULA H. HIGUERO Juliao Rua Araguaia 48 DeptOd e Psiquiatria 36100 Juiz de Fora, MG Universidad de Panama BRAZIL Panama Ciudad PANAMA M. DISTEFANI Rua Nove de Julho 830 aptO2 6 G. M. JACOBIDES 14800 Araraquara, S P Neofitou Vamva 5 BRAZIL Athens 138 GREECE A. C. ESPONDA F. JESSURUM CIAT - Centro de Informaciones c/o Hoffmann-La Roche B.v. y Asesoramiento Toxicol6gico Nijverheidsweg 38 Hospital de Clinicas 3641 RR Mijdrecht Montevideo NETHERLANDS URUGUAY M. R. JORGE N. de Moura FE Rua Joinville 651 - Ibirapuera Rua Joaquim Lima 436 Sao Paulo, SP 60000 Fortaleza, CE BRAZIL BRAZIL S. C. KAIM R. G, FELDMAN Biometric Research Institute, Inc. Dept. of Neurology 1010 Wisconsin Ave. N.W. Boston University Medical Center Washington, DC 20007 80 East Concord Street USA Boston, Mass. 02118 USA S. A. KAPLAN Dept. of Pharmacokinetics and M. P. de Toledo FERRAZ Biopharmaceutics Rua Borges Lagoa 394 Hoffmann..c.La Roche Inc. 04038 Sao Paulo, SP Nutley, NJ 07110 BRAZIL USA LIST OF CONTRIBUTORS AND PARTICIPANTS Xl I. G. KARNIOL M. P. LlSON Dept" de Psiquiatria e Psicologia Rua Visconde de Inhauma 1566 Medica 14100 Ribeir~o Preto, SP Fac. Ciencias Medicas/UNICAMP BRAZIL Rua Jose Theodoro Lima 44 13100 Campinas, SP J. L. LOPES BRAZIL Rua Visconde de Caravelas 111 22271 Rio de Janeiro, RJ D. KELLY BRAZIL The Priory Hospital Priory Lane, Roehampton G. LORETO London SW1 5 5JJ Rua Virginia Loreto 88 ENGLAND 50000 Recife, PE BRAZIL A. van der KUY c/o Hoffmann-La Roche B.V. J. C. MADALENA Nijverheidsweg 38 Casa de Saude Dr. Eiras 3641 RR Mijdrecht NETHERLANDS Rua Assun~ao 2 22251 Rio de Janeiro, RJ BRAZIL D. LADEWIG Psychiatrische Universitatsklinik Wilhelm Klein-Strasse 27 P. MARIZ CH 4025 Basle Coordenadoria de Saude Mental SWITZERLAND Pra~a Oswaldo Cruz, sin 50000 Recife, PE Y. D. LAPIERRE BRAZIL 197 Cumberland Street Ottawa, Ontario K1 N 7H4 M. C. C. A. MARTINS CANADA Dept" de Psiquiatria Centro de Ciencias da Saude B. LEISHMAN Univ. Federal de Pernambuco' Dept. of Clinical Investigation and 50000 Recife, PE Development BRAZIL F. Hoffmann-La Roche & Co. Ltd. CH 4002 Basle E. G. MATOS SWITZERLAND Dept" de Psiquiatria e Psicologia Medica J. LEMOS Fac. Ciencias Medicas/UNICAMP Dept" de Psiquiatria Rua Jose Theodoro Lima 44 Centro de Ciencias da Saude 13100 Campinas, SP Univ. Federal de Pernambuco BRAZIL 50000 Recife, PE BRAZIL D. McCLURE L. M. LESSA St. Mary's Hospital 3830 Lacombe Ave., room 3207 Parque Lucaia, rua D, qd.E, lote 3 Montreal, Quebec H3T 1 M5 Rio Vermelho CANADA 40000 Salvador, BA BRAZIL R. MONTENEGRO M. LEVY Jr. Instituto Equatoriano de Securidad Rua Carauna 148 Social 05449 Sao Paulo, SP Quito BRAZIL EQUADOR XII BENZODlAZEPINES TODAY AND TOMORROW M. J. F. MOREIRA M. POINEAU DeptO de Psiquiatria e Psicologia Produits Roche S.A. Medica 52, Boulevard du Parc Fac. Ciencias Medicas/UNICAMP 92241 Neuilly-sur-Seine Rua Jose Theodoro Lima 44 FRANCE 13100 Campinas, SP BRAZIL J. U. POSTMA c/o Hoffmann-La Roche B.V. M. S. MOREIRA Nijverheidsweg 38 CHnica Psiquiatrica da Escola 3641 RR Mijdrecht de Medicina e Cirurgia NETHERLANDS Rio de Janeiro, FEFIERJ, RJ R. G. PRIEST BRAZIL St. Mary's Hospital Dept. of Psychiatry E. M. OLIVEIRA NETO Harrow Road Rua Clodomiro Amazonas 443 London W9 3RL 04537 Sao Paulo, SP ENGLAND BRAZIL L. RAMIREZ Ruiz I. F. PAlM Centro Nacional de Farmacobiologia SOS 114, bloco H, aptO 102 Ministerio de Sanidad y 70377 Brasilia, 0 F Securidad Social BRAZIL Majadahonda Madrid J. PAPROCKI SPAIN GPC - Grupo de Estudos em Psicofarmacologia CHnica J. M. van ROSSUM Rua Dom Lucio Antunes 360 c/o Hoffmann-La Roche B.V. 30000 Belo Horizonte, MG Nijverheidsweg 38 BRAZIL 3641 RR Mijdrecht NETHERLANDS L. PEPPLlNKHUIZEN A. c/o Hoffmann-La Roche BV. RUBIM DE PINHO Nijverheidsweg 38 Largo da Vit6ria 2 aptO1 01 3641 R R M ijdrecht 40000 Salvador, BA NETHERLANDS BRAZIL N. de Souza SAMPAIO P. E. PICAN<.(O Escola de Medicina e Saude Publica Rua Dr. Jose Lourenc;:o 1645 Rua Frei Henrique 8 60000 Fortaleza, CE 40000 Salvador, BA BRAZIL BRAZIL A. E. PIEDRABUENA M. A. S. L. SANTOS DeptO de Psiquatria e Psicologia DeptO de Psiquiatria Medica Centro de Ciencias da Saude Fac. Ciencias Medicas/UNICAMP Univ. Federal de Pernambuco Rua Jose Theodoro Lima 44 50000 Recife, PE 13100 Campinas, SP BRAZIL BRAZIL J. A. SCHIPPER W. POLDINGER clo Hoffmann-La Roche B.V. Kantonale Psychiatrische Klinik A Nijverheidsweg 38 CH 9500 Wil/St. Gallen 3641 RR Mijdrecht SWITZERLAND NETHERLANDS
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