B Cell Receptor Signaling PDF
Preview B Cell Receptor Signaling
Current Topics in Microbiology and Immunology Tomohiro Kurosaki Jürgen Wienands Editors B Cell Receptor Signaling Current Topics in Microbiology and Immunology Volume 393 Serieseditors RafiAhmed SchoolofMedicine,RollinsResearchCenter,EmoryUniversity,RoomG211,1510CliftonRoad,Atlanta,GA30322, USA KlausAktories MedizinischeFakultät,Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Abt. I, Albert-Ludwigs-UniversitätFreiburg,Albertstr.25,79104,Freiburg,Germany RichardW.Compans DepartmentofMicrobiologyandImmunology,EmoryUniversity,1518CliftonRoad,CNR5005,Atlanta,GA30322, USA MaxD.Cooper Department of Pathology and Laboratory Medicine, Georgia Research Alliance, Emory University, 1462 Clifton Road, Atlanta, GA 30322, USA JorgeE.Galan Boyer Ctr. for Molecular Medicine, School of Medicine, Yale University, 295 Congress Avenue, room 343, New Haven, CT 06536-0812, USA TasukuHonjo Faculty of Medicine, Department of Medical Chemistry, Kyoto University, Sakyo-ku, Yoshida, Kyoto 606-8501, Japan YoshihiroKawaoka InfluenzaResearchInstitute,UniversityofWisconsin-Madison,575ScienceDrive,Madison,WI53711,USA BernardMalissen Centre d’Immunologie de Marseille-Luminy, Parc Scientifique de Luminy, Case 906, 13288, Marseille Cedex 9, France MichaelB.A.Oldstone DepartmentofImmunologyandMicrobialScience,TheScrippsResearchInstitute,10550NorthTorreyPinesRoad,, LaJolla,CA92037,USA RinoRappuoli NovartisVaccines,ViaFiorentina1,Siena,53100,Italy PeterK.Vogt DepartmentofMolecularandExperimentalMedicine,TheScrippsResearchInstitute,10550NorthTorreyPines Road,BCC-239,LaJolla,CA92037,USA HonoraryEditor:HilaryKoprowski(deceased) FormerlyatBiotechnologyFoundation,Inc.,Ardmore,PA,USA More information about this series at http://www.springer.com/series/82 ü Tomohiro Kurosaki J rgen Wienands (cid:129) Editors B Cell Receptor Signaling Responsible Series Editor: Tasuko Honjo 123 Editors TomohiroKurosaki JürgenWienands WPIImmunology Frontier Research Center Cellular andMolecular Immunology Osaka University Georg AugustUniversity Goettingen Osaka Göttingen Japan Germany ISSN 0070-217X ISSN 2196-9965 (electronic) CurrentTopics inMicrobiology andImmunology ISBN978-3-319-26131-7 ISBN978-3-319-26133-1 (eBook) DOI 10.1007/978-3-319-26133-1 LibraryofCongressControlNumber:2015957116 SpringerChamHeidelbergNewYorkDordrechtLondon ©SpringerInternationalPublishingSwitzerland2016 Thisworkissubjecttocopyright.AllrightsarereservedbythePublisher,whetherthewholeorpart of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilarmethodologynowknownorhereafterdeveloped. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt fromtherelevantprotectivelawsandregulationsandthereforefreeforgeneraluse. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained hereinorforanyerrorsoromissionsthatmayhavebeenmade. Printedonacid-freepaper SpringerInternationalPublishingAGSwitzerlandispartofSpringerScience+BusinessMedia (www.springer.com) Preface Regulatory Signal Networks of the B Cell Antigen Receptor B lymphocytes recognize pathogens by virtue of their cognate B cell antigen receptor (BCR) on the cell surface. BCR ligation is a critical step for antibody-mediated immune responses as it triggers a series of converging pro- cesses, resulting in the generation of memory B cells or antibody-forming plasma cells. The existence of the BCR was first postulated by Paul Ehrlich in his famous ‘SideChainTheory’ofantibodyformationmorethan125yearsago.Theideawas developedfurtherbyBurnetandTalmageintheirclonalselectionhypothesiswhich predicted that the diversity of the immune response is due to selection and expansion of B lymphocytes. Although originally invoked to account for the pro- posed antigen-specific activation of B cell clones, it is clear that the BCR plays a centralroleindeterminingthefateofBcellsevenbeforeitencountersantigen.For instance, progressionthroughthepre-B cell stageofdifferentiation depends onthe presence of the pre-BCR, which is composed offunctional heavy chains and sur- rogate light chains with their signaling subunits, Igα and Igβ. The outcomes of these developmental responses as well as antigen-specific responses are mediated by signal transduction through the BCR. Transmembrane signaling is further regulated or fine-tuned by an array of cytoplasmic signal transduction mechanisms. This volume of Current Topics in Microbiology and Immunology is aimed at reviewing the recent progress regarding how the BCR undergoes activation and endocytosis, and how such stimulation evokes cytoplas- mic and subsequent nuclear signaling events. Leading Experts in these various aspects including Hassan Jumaa, Michael Reth, Pavel Tolar, and colleagues have contributed chapters on specific aspects of initiation of pre-BCR and BCR, while Rudi Hendricks, Jürgen Wienands, Klaus Okkenhaug, Yoshihiro Baba, and v vi Preface colleagues describe the cytoplasmic signaling networks. Lastly, Yoshiteru Sasaki, Tomoharu Yasuda, and colleagues discuss intermediate events between cytoplas- mic and nuclear signaling. Tomohiro Kurosaki Jürgen Wienands Contents Part I Initiation of B Cell Receptor Signaling Assembly and Function of the Precursor B-Cell Receptor. . . . . . . . . . . 3 Rudolf Übelhart, Markus Werner and Hassan Jumaa Receptor Dissociation and B-Cell Activation. . . . . . . . . . . . . . . . . . . . . 27 Jianying Yang and Michael Reth Molecular Mechanisms of B Cell Antigen Gathering and Endocytosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45 Robbert Hoogeboom and Pavel Tolar Part II BTKs, Adaptors, and Effector System in B Cell Receptor Signaling BTK Signaling in B Cell Differentiation and Autoimmunity . . . . . . . . . 67 Odilia B.J. Corneth, Roel G.J. Klein Wolterink and Rudi W. Hendriks The Memory Function of the B Cell Antigen Receptor. . . . . . . . . . . . . 107 Jürgen Wienands and Niklas Engels PI3K Signaling in Normal B Cells and Chronic Lymphocytic Leukemia (CLL). . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 123 Klaus Okkenhaug and Jan A. Burger Role of Calcium Signaling in B Cell Activation and Biology . . . . . . . . . 143 Yoshihiro Baba and Tomohiro Kurosaki vii viii Contents Part III Connection Between Cytoplasmic and Nuclear Events Roles of the NF-κB Pathway in B-Lymphocyte Biology. . . . . . . . . . . . . 177 Yoshiteru Sasaki and Kazuhiro Iwai MAP Kinase Cascades in Antigen Receptor Signaling and Physiology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 211 Tomoharu Yasuda Part I Initiation of B Cell Receptor Signaling
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